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https://www.readbyqxmd.com/read/29793019/factors-predicting-non-compliance-with-follow-up-after-endovascular-aneurysm-repair
#1
Timothy P Shiraev, Elif Durur, David A Robinson
PURPOSE: Although the potential for complications following endovascular aneurysm repair (EVAR) mandates lifetime follow-up, non-compliance with follow-up has been shown to be as high as 57%. We sought to investigate the incidence of non-compliance with follow up in our patient population and to identify risk factors associated with this, in order to allow implementation of targeted strategies to prevent loss to follow up. METHODOLOGY: We carried out a review of consecutive patients undergoing EVAR at two Sydney hospitals between 1995 and 2015...
May 21, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29792974/patient-compliance-with-maintenance-intravesical-therapy-for-non-muscle-invasive-bladder-cancer
#2
Shlomi Tapiero, Alexander Helfand, Daniel Kedar, Ofer Yossepowitch, Andrei Nadu, Jack Baniel, David Lifshitz, David Margel
OBJECTIVE: To assess patient adherence to intravesical instillation therapy for non-muscle invasive urothelial carcinoma outside of clinical trials. METHODS: We reviewed the records of patients from 2000-2013 who received intravesical therapy for non-muscle invasive urothelial carcinoma. Patients with evidence of tumor recurrence or progression were excluded. We performed univariable and multivariable regression analysis to predict adherence to intravesical therapy...
May 21, 2018: Urology
https://www.readbyqxmd.com/read/29792971/impact-of-active-surveillance-and-infection-control-measures-on-carbapenem-resistant-gram-negative-bacterial-colonization-and-infections-in-intensive-care
#3
T Karampatakis, K Tsergouli, E Iosifidis, C Antachopoulos, A Karapanagiotou, A Karyoti, N Gritsi-Gerogianni, A Tsakris, E Roilides
BACKGROUND: Carbapenem-resistant Gram-negative bacteria (CRGNB) infections constitute a global threat for critically ill patients and the outcome of their hospitalization. Early identification of CRGNB through rectal surveillance cultures and routine infection control measures including contact precautions, use of appropriate disinfectants, staff education on cleaning, and hand hygiene may reduce the dissemination of CRGNB. AIM: To assess the impact of enhanced infection control measures on CRGNB infections in a nine-bed polyvalent intensive care unit in a tertiary level hospital in an endemic area...
May 21, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29792911/prolonged-drug-release-properties-for-orodispersible-films-by-combining-hot-melt-extrusion-and-solvent-casting-methods
#4
Isabell Speer, Maren Preis, Jörg Breitkreutz
Orodispersible films (ODFs) are an advantageous dosage form to accomplish patient convenience and compliance in oral drug delivery. They provide a number of special application features, such as the ease of administration without water and suitability for patients with swallowing problems. However, this promising dosage form has been limited to immediate release formulations so far. The aim of this study was to develop a thin film produced by solvent casting, which is rapidly disintegrating when placed in the mouth, but which provides prolonged drug release characteristics by incorporating drug-loaded matrix particles (MPs)...
May 21, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29792889/ros-triggered-degradable-iron-chelating-nanogels-safely-improving-iron-elimination-in-vivo
#5
Zhi Liu, Jing Qiao, Tamas Nagy, May P Xiong
Iron-mediated generation of highly toxic Reactive Oxygen Species (ROS) plays a major role in the process leading to iron overload-related diseases. The long-term subcutaneous administration of Deferoxamine (DFO) is currently clinically-approved to improve patient symptoms and survival. However, non-specific toxicity and short circulation times of the drug in humans often leads to poor patient compliance. Herein, thioketal-based ROS-responsive polymeric nanogels containing DFO moieties (rNG-DFO) were designed to chelate iron and to degrade under oxidative stimuli into fragments <10 nm to enhance excretion of iron-bound chelates...
May 21, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29792143/recent-updates-on-novel-approaches-in-insulin-drug-delivery-a-review-of-challenges-and-pharmaceutical-implications
#6
Manisha Pandey, Hira Choudhury, Cheah Xiao Yi, Chen Wei Mun, Goh Khang Ping, Guee Xin Rou, Bhalqish Jeet Kaur A/P Ambar Jeet Singh, Angel Ng Ann Jhee, Lee Kai Chin, Prashant Kesharwani, Bapi Gorain, Zahid Hussain
Diabetes mellitus, a metabolic disorder of glucose metabolism, is mainly associated with insulin resistance to the body cells, or impaired production of insulin by the pancreatic β-cells. Insulin is mainly required to regulate glucose metabolism in type 1 diabetes mellitus patients; however, many patients with type 2 diabetes mellitus also require insulin, especially when their condition cannot be controlled solely by oral hypoglycemic agents. Hence, major researches are ongoing attempting to improve the delivery of insulin in order to make it more convenient to patients who experience side effects from the conventional treatment procedure or non-adherence to insulin regimen due to multiple comorbid conditions...
May 22, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29791699/a-comparative-effectiveness-study-for-non-operative-treatment-methods-for-knee-osteoarthritis
#7
Frank R Kolisek, Charles Jaggard, Anton Khlopas, Assem A Sultan, Nipun Sodhi, Michael A Mont
A number of non-operative treatment options are commonly prescribed for patients presenting with degenerative osteoarthritis of the knee, where surgery is not yet recommended. However, there is a paucity of studies evaluating the comparative effectiveness of these treatment options to best inform both patients and providers. This study examined the comparative effectiveness of a home exercise program versus bracing or a combination of the two (brace-only, exercise-only, and brace and exercise cohorts) on the following: 1) objective functional measures (quadriceps muscle strength, Self-Paced Walk Test [SPWT], and Timed "Up & Go" [TUG] Test); 2) subjective functional measures (Lower Extremity Function Scale [LEFS] and Health Survey [VR-12] outcomes); 3) pain using Visual Analog Scale [VAS-10]; 4) patient metrics (patient treatment preference, perceptions, and compliance); and 5) progression to total knee arthroplasty (TKA) over a 12-week period...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791176/-a-consensual-therapeutic-recommendation-for-type-2-diabetes-mellitus-by-the-slovak-diabetes-society-2018
#8
Emil Martinka, Vladimír Uličiansky, Marián Mokáň, Ivan Tkáč, Peter Galajda, Silvia Dókušová, Zbynek Schroner
Type 2 diabetes mellitus is a heterogeneous medical condition involving multiple pathophysiological mechanisms. Its successful treatment requires an individualized approach and frequently combined therapy with utilizing its effect on multiple levels. Current possibilities enable the employment of such procedures to an incomparably greater extent than before. The effects of different classes of oral antidiabetic drugs on the reduction of glycemia and HbA1c is mutually comparable. However differences are observed in the proportions of patients who met the required criteria, regarding the increase in weight, incidence of hypoglycemia as well as the effect on cardiovascular, renal or oncologic morbidity and mortality, and severity of specific adverse effects, potential risks and contraindications...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29790278/the-split-dose-4-l-polyethylene-glycol-regimen-for-patients-with-previous-colorectal-surgery-in-bowel-preparation-before-colonoscopy-a-randomized-controlled-single-blind-study
#9
Zhu Liu, Yue-Yue Li, Xue-Ting Luo, Chuan-Guo Guo, Ming-Ming Zhang, Zhen Li, Li-Xiang Li, Yan Zhang, Yan-Qing Li
AIM: In some Asian countries, guidelines recommend 2-L polyethylene glycol (PEG) without any additions as the standard bowel preparation (BP) regimen before colonoscopy, which is not sufficient for patients with previous colorectal surgery. The objective of this study was to investigate the efficacy of the split-dose 4-L PEG regimen on the quality of BP in Asian patients with previous colorectal surgery. METHODS: This was a single-center, prospective, randomized-controlled, endoscopist-blinded study...
May 22, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29790022/compliance-with-pregnancy-prevention-recommendations-for-isotretinoin-in-estonia-in-2012-2016
#10
Anneli Uusküla, Heti Pisarev, Katrin Kurvits, Ott Laius, Made Laanpere, Maia Uusküla
BACKGROUND: Isotretinoin is an effective treatment for severe acne; no alternative treatment has an equal therapeutic effect. The teratogenic effects of isotretinoin can be avoided, and numerous recommendations and regulations are in force to minimize the risk of pregnancy during treatment. OBJECTIVES: To describe isotretinoin prescription patterns for women aged 15-45 years, assess the concomitancy of isotretinoin and contraceptive use, and determine the rate of potential isotretinoin-exposed pregnancies in Estonia...
May 22, 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29789971/compliance-with-an-enhanced-recovery-after-a-surgery-program-for-patients-undergoing-gastrectomy-for-gastric-carcinoma-a-phase-2-study
#11
Mi Ran Jung, Seong Yeob Ryu, Young Kyu Park, Oh Jeong
BACKGROUND: Enhanced recovery after surgery (ERAS) programs have gained widespread acceptance in different fields of major surgery. However, most elements of perioperative care in ERAS are based on practices that originated from colorectal surgery. This study investigated compliance with the main elements of ERAS for patients undergoing gastrectomy for gastric carcinoma. METHODS: This phase 2 study enrolled 168 patients undergoing elective gastrectomy for gastric carcinoma...
May 22, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29789468/in-vitro-evaluation-of-2d-printed-edible-films-for-the-buccal-delivery-of-diclofenac-sodium
#12
Georgios K Eleftheriadis, Paraskevi Kyriaki Monou, Nikolaos Bouropoulos, Dimitrios G Fatouros
Printing technologies have recently emerged in the development of novel drug delivery systems toward personalized medicine, to improve the performance of formulations, existing bioavailability patterns, and patients' compliance. In the context of two-dimensional printing, this article presents the development of buccal films that are designed to efficiently deliver a class II compound (diclofenac sodium), according to the Biopharmaceutics Classification System (BCS), to the oral cavity. The preparation of drug-loaded inks was carried out based on solubility studies and evaluation of rheological properties, combining ethanol and propylene glycol as optimal solvents...
May 22, 2018: Materials
https://www.readbyqxmd.com/read/29788846/-patient-vs-physician-reported-implementation-of-and-compliance-to-anti-osteoporotic-medication-one-year-after-sustained-fragility-fracture
#13
Thomas Gross
Patient- vs Physician-Reported Implementation of and Compliance to Anti-Osteoporotic Medication One Year after Sustained Fragility Fracture Abstract. We were interested why therapy recommendations made by specialists are often not followed by general practitioners (GPs) and patients. We evaluated systematic questionnaires comparing both, patient and GP statements (n = 151 each) with regard to the implementation of and compliance to specific therapy recommended by an osteologic specialist one year after an osteoporotic fracture...
2018: Praxis
https://www.readbyqxmd.com/read/29788170/systematic-review-and-meta-analysis-of-the-evidence-for-oral-nutritional-intervention-on-nutritional-and-clinical-outcomes-during-chemo-radio-therapy-current-evidence-and-guidance-for-design-of-future-trials
#14
M A E de van der Schueren, A Laviano, H Blanchard, M Jourdan, J Arends, V E Baracos
Background: Driven by reduced nutritional intakes and metabolic alterations, malnutrition in cancer patients adversely affects quality of life, treatment tolerance and survival. We examined evidence for oral nutritional interventions during chemo(radio)therapy. Design: We carried out a systematic review of randomized controlled trials (RCT) with either dietary counseling (DC), high-energy oral nutritional supplements (ONS) aiming at improving intakes or ONS enriched with protein and n-3 polyunsaturated fatty acids (PUFA) additionally aiming for modulation of cancer-related metabolic alterations...
May 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29788110/long-term-compliance-with-a-validated-intravenous-insulin-therapy-protocol-in-cardiac-surgery-patients-a-quality-improvement-project
#15
Guillaume Besch, Andrea Perrotti, Lucie Salomon du Mont, Raphaelle Tucella, Guillaume Flicoteaux, Aline Bondy, Emmanuel Samain, Sidney Chocron, Sebastien Pili-Floury
Quality problem: Safe and efficient blood glucose (BG) level control after cardiac surgery relies on an intensive care unit (ICU) team-based approach, including implementation of a dynamic insulin therapy protocol (ITP). Long-term compliance with such a complex protocol is poorly addressed in the literature. The aim of this study was to assess the long-term compliance of nurses with the ITP, 7 years after its implementation in the ICU. Initial assessment: A professional practice evaluation, integrated in a process of quality improvement program, was retrospectively conducted on 224 consecutive cardiac surgery patients over a 6-month period (PHASE 1)...
May 18, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29787813/vascular-involvement-in-axial-spondyloarthropathies
#16
Clément Prati, Céline Demougeot, Xavier Guillot, Maxime Sondag, Frank Verhoeven, Daniel Wendling
Ankylosing spondylitis (AS) is a chronic inflammatory joint disease that involves the entheses, causing inflammatory pain and functional impairments. Patients may experience extraarticular manifestations such as uveitis, psoriasis, and inflammatory bowel disease. These, together with the increased risk of cardiovascular disease and osteoporosis and the development of spinal fusion, are the main determinants of adverse disease outcomes. As with many systemic inflammatory diseases, AS is associated with excess cardiovascular mortality due to increased risks of myocardial infarction, stroke, and venous thromboembolism...
May 19, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29787579/conformity-of-package-inserts-information-to-regulatory-requirements-among-selected-branded-and-generic-medicinal-products-circulating-on-the-east-african-market
#17
Hiiti B Sillo, Nelson E Masota, Sunday Kisoma, Lembit Rago, Veronica Mgoyela, Eliangiringa A Kaale
BACKGROUND: Availability of correct and adequate information about medicines is an important aspect in ensuring rational use of medicines and hence facilitating safety and expected efficacy of medicines during therapy. Package inserts have proven to be a good source of information to the prescribers and patients whereby they have been useful in highlighting important information pertaining proper use and handling of the medicines. The present study was aimed at establishing the extent to which package inserts of medicines circulating on the markets of the East African Community (EAC) Partner States conform to medicines information requirements as established in the harmonized guidelines as well as national guidelines...
2018: PloS One
https://www.readbyqxmd.com/read/29787486/a-random-dot-computer-video-game-improves-stereopsis
#18
Juan A Portela-Camino, Santiago Martín-González, Javier Ruiz-Alcocer, Igor Illarramendi-Mendicute, Rafaela Garrido-Mercado
SIGNIFICANCE: Currently, treatments for amblyopia are occlusion or penalization of the stronger fellow eye. Fewer than 30% of patients improve stereoacuity using these treatments. In order to improve these outcomes, this group proposes a treatment to stimulate the stereoacuity through perceptual learning in a game format for use at home. PURPOSE: The aim of this study was to determine whether perceptual learning with random dot stimuli (RDS) in the form of a computer video game improves stereopsis in patients with a history of amblyopia...
May 21, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29786774/computational-fluid-dynamics-modeling-of-the-human-pulmonary-arteries-with-experimental-validation
#19
Alifer D Bordones, Matthew Leroux, Vitaly O Kheyfets, Yu-An Wu, Chia-Yuan Chen, Ender A Finol
Pulmonary hypertension (PH) is a chronic progressive disease characterized by elevated pulmonary arterial pressure, caused by an increase in pulmonary arterial impedance. Computational fluid dynamics (CFD) can be used to identify metrics representative of the stage of PH disease. However, experimental validation of CFD models is often not pursued due to the geometric complexity of the model or uncertainties in the reproduction of the required flow conditions. The goal of this work is to validate experimentally a CFD model of a pulmonary artery phantom using a particle image velocimetry (PIV) technique...
May 21, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29786508/-use-of-the-evalobs-%C3%A2-adherence-scale-in-an-unselected-french-population-of-treated-subjects-with-antihypertensive-hypolipemiants-or-oral-antidiabetics-medications-the-flahs-2017-adherence-survey
#20
X Girerd, O Hanon, B Vaïsse
OBJECTIVE: A Visual Analog Scale (VAS) is useful for diagnosing medication nonadherence and its validity has been evaluated using electronic pillbox as the gold standard. We have developed the EvaLobs® scale for use on paper or on smartphone and the aim of the study was to administrate the scale among FLAHS 2017 participants treated for an hypertension, a dyslipidemia or diabetes. In subjects treated with antihypertensive medications, participants completed the 6-item Girerd Scale and EvaLobs® ...
May 18, 2018: Annales de Cardiologie et D'angéiologie
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