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Uremic cardiomyopathy

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https://www.readbyqxmd.com/read/27811451/expressions-of-macrophage-migration-inhibitory-factor-in-patients-with-chronic-kidney-disease
#1
Y Liu, X Zhang, G Liu, J Huang, Y Pan, Z Hu
CONTEXT: Uremic cardiomyopathy is a risk factor of end-stage renal disease (ESRD) and is responsible for high mortality rates and increased left ventricular mass index (LVMI). Macrophage migration inhibitory factor (MIF) promotes inflammation and is an important factor in uremic cardiomyopathy. AIMS: The aim of this study is to investigate the effects of serum macrophage MIF on myocardial hypertrophy in ESRD patients and to examine the relation of this factor to clinical characteristics...
November 2016: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27725315/cardiac-actions-of-fibroblast-growth-factor-23
#2
REVIEW
Christian Faul
Fibroblast growth factors (FGF) are mitogenic signal mediators that induce cell proliferation and survival. Although cardiac myocytes are post-mitotic, they have been shown to be able to respond to local and circulating FGFs. While precise molecular mechanisms are not well characterized, some FGF family members have been shown to induce cardiac remodeling under physiologic conditions by mediating hypertrophic growth in cardiac myocytes and by promoting angiogenesis, both events leading to increased cardiac function and output...
October 7, 2016: Bone
https://www.readbyqxmd.com/read/27698370/attenuation-of-na-k-atpase-mediated-oxidant-amplification-with-pnaktide-ameliorates-experimental-uremic-cardiomyopathy
#3
Jiang Liu, Jiang Tian, Muhammad Chaudhry, Kyle Maxwell, Yanling Yan, Xiaoliang Wang, Preeya T Shah, Asad A Khawaja, Rebecca Martin, Tylor J Robinette, Adee El-Hamdani, Michael W Dodrill, Komal Sodhi, Christopher A Drummond, Steven T Haller, David J Kennedy, Nader G Abraham, Zijian Xie, Joseph I Shapiro
We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant amplification might ameliorate experimental uremic cardiomyopathy induced by partial nephrectomy (PNx). PNx induced the development of cardiac morphological and biochemical changes consistent with human uremic cardiomyopathy. Both inhibition of Na/K-ATPase oxidant amplification with pNaKtide and induction of heme oxygenase-1 (HO-1) with cobalt protoporphyrin (CoPP) markedly attenuated the development of phenotypical features of uremic cardiomyopathy...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27694325/rapamycin-attenuates-cardiac-fibrosis-in-experimental-uremic-cardiomyopathy-by-reducing-marinobufagenin-levels-and-inhibiting-downstream-pro-fibrotic-signaling
#4
Steven T Haller, Yanling Yan, Christopher A Drummond, Joe Xie, Jiang Tian, David J Kennedy, Victoria Y Shilova, Zijian Xie, Jiang Liu, Christopher J Cooper, Deepak Malhotra, Joseph I Shapiro, Olga V Fedorova, Alexei Y Bagrov
BACKGROUND: Experimental uremic cardiomyopathy causes cardiac fibrosis and is causally related to the increased circulating levels of the cardiotonic steroid, marinobufagenin (MBG), which signals through Na/K-ATPase. Rapamycin is an inhibitor of the serine/threonine kinase mammalian target of rapamycin (mTOR) implicated in the progression of many different forms of renal disease. Given that Na/K-ATPase signaling is known to stimulate the mTOR system, we speculated that the ameliorative effects of rapamycin might influence this pathway...
September 30, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27598118/the-role-of-na-k-atpase-signaling-in-oxidative-stress-related-to-obesity-and-cardiovascular-disease
#5
REVIEW
Krithika Srikanthan, Joseph I Shapiro, Komal Sodhi
Na/K-ATPase has been extensively studied for its ion pumping function, but, in the past several decades, has been identified as a scaffolding and signaling protein. Initially it was found that cardiotonic steroids (CTS) mediate signal transduction through the Na/K-ATPase and result in the generation of reactive oxygen species (ROS), which are also capable of initiating the signal cascade. However, in recent years, this Na/K-ATPase/ROS amplification loop has demonstrated significance in oxidative stress related disease states, including obesity, atherosclerosis, heart failure, uremic cardiomyopathy, and hypertension...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27219043/the-role-of-fibroblast-growth-factor-23-and-klotho-in-uremic-cardiomyopathy
#6
Alexander Grabner, Christian Faul
PURPOSE OF REVIEW: In chronic kidney disease (CKD), multiple factors contribute to the development of cardiac hypertrophy by directly targeting the heart or indirectly by inducing systemic changes such as hypertension, anemia, and inflammation. Furthermore, disturbances in phosphate metabolism have been identified as nonclassical risk factors for cardiovascular mortality in these patients. With declining kidney function, the physiologic regulators of phosphate homeostasis undergo changes in their activity as well as their circulating levels, thus potentially contributing to cardiac hypertrophy once they are out of balance...
July 2016: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/27125747/deficiency-of-soluble-%C3%AE-klotho-as-an-independent-cause-of-uremic-cardiomyopathy
#7
J Xie, Y-L Wu, C-L Huang
Cardiovascular disease (CVD) is the major cause of mortality for patients with chronic kidney disease (CKD). Cardiac hypertrophy, occurring in up to 95% patients with CKD (also known as uremic cardiomyopathy), increases their risk for cardiovascular death. Many CKD-specific risk factors of uremic cardiomyopathy have been recognized, such as secondary hyperparathyroidism, indoxyl sulfate (IS)/p-cresyl, and vitamin D deficiency. However, several randomized controlled trials have recently shown that these risk factors have little impact on the mortality of CVD...
2016: Vitamins and Hormones
https://www.readbyqxmd.com/read/26997631/myocardial-dysfunction-occurs-prior-to-changes-in-ventricular-geometry-in-mice-with-chronic-kidney-disease-ckd
#8
Pamela D Winterberg, Rong Jiang, Josh T Maxwell, Bo Wang, Mary B Wagner
Uremic cardiomyopathy is responsible for high morbidity and mortality rates among patients with chronic kidney disease (CKD), but the underlying mechanisms contributing to this complex phenotype are incompletely understood. Myocardial deformation analyses (ventricular strain) of patients with mild CKD have recently been reported to predict adverse clinical outcome. We aimed to determine if early myocardial dysfunction in a mouse model of CKD could be detected using ventricular strain analyses. CKD was induced in 5-week-old male 129X1/SvJ mice through partial nephrectomy (5/6Nx) with age-matched mice undergoing bilateral sham surgeries serving as controls...
March 2016: Physiological Reports
https://www.readbyqxmd.com/read/26891193/the-physiological-and-clinical-importance-of-sodium-potassium-atpase-in-cardiovascular-diseases
#9
REVIEW
Yanling Yan, Joseph I Shapiro
The Na/K-ATPase has been extensively studied, but it is only recently that its role as a scaffolding and signaling protein has been identified. It has been identified that cardiotonic steroids (CTS) such as digitalis mediate signal transduction through the Na/K-ATPase in a process found to result in the generation of reactive oxygen species (ROS). As these ROS also appear capable of initiating this signal cascade, a feed forward amplification process has been postulated and subsequently implicated in some disease pathways including uremic cardiomyopathy...
April 2016: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/26877504/p-196-echocardiographic-manifestations-of-the-uremic-cardiomyopathy-about-16-cases
#10
R Ben Dhia, Y Ben Ariba, N Boussetta, N Ben Abdelha-Fidh, F Ajili, B Louzir, J Labidi, S Othmani
OBJECTIFS: Les atteintes cardiovasculaires représentent la principale cause de mortalité des patients avec insuffisance rénale chronique terminale. La prévalence ainsi que l'évaluation des autres facteurs de risques associés de l'atteinte cardiaque est une étape importante dans la prise en charge des malades en préhémodialyse. L'objectif de notre étude était de décrire les caractéristiques échocardiographiques de la cardiomyopathie urémique. MéTHODES: Notre étude a été menée sur 16 patients hospitalisés entre 2013 et 2014 au service de médecine interne de l'Hôpital Militaire de Tunis colligeant 16 patients ayant eu une échographie cardiaque dans le cadre d'un bilan pré-hémodialyse...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26765262/involvement-of-endoplasmic-reticulum-stress-in-uremic-cardiomyopathy-protective-effects-of-tauroursodeoxycholic-acid
#11
Wei Ding, Bin Wang, Minmin Zhang, Yong Gu
BACKGROUND/AIMS: Uremic cardiomyopathy (UCM) is a complication in chronic kidney disease. We investigated if endoplasmic reticulum stress (ERS) is involved in UCM, and determined the efficacy of tauroursodeoxycholic acid (TUDCA) in UCM prevention. METHODS: Mice were divided randomly into three groups: sham (saline, i.p), 5/6 nephrectomized (Nx) (saline, i.p) and Nx+TUDCA (250 mg/kg/day, i.p.). Renal function was assessed by measuring serum creatinine, blood urea nitrogen and by periodic acid-Schiff reagent staining...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/26714905/-protective-effects-of-zhenwutang-on-cardiac-function-in-mice-with-uremic-cardiomyopathy-induced-by-subtotal-nephrectomy
#12
Qi Chen, Zhiliang Li, Bei Liu, Qiang Fu, Quanneng Yan
OBJECTIVE: To investigate the protective effects of Zhenwutang (ZWT) on cardiac function in mice with uremic cardiomyopathy (UCM). METHODS: Thirty C57BL/6 mice were randomized into 3 equal groups, including a sham-operated group, subtotal nephrectomy (UCM model) group and subtotal nephrectomy with ZWT treatment group. The mice in the former two groups were treated with distilled water. The changes in cardiac functions, myocardial structure and renal function of the mice were evaluated with echocardiography, HE staining and biochemical assay, respectively...
December 2015: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/26702050/na-k-atpase-signaling-regulates-collagen-synthesis-through-microrna-29b-3p-in-cardiac-fibroblasts
#13
Christopher A Drummond, Michael C Hill, Huilin Shi, Xiaoming Fan, Jeffrey X Xie, Steven T Haller, David J Kennedy, Jiang Liu, Michael R Garrett, Zijian Xie, Christopher J Cooper, Joseph I Shapiro, Jiang Tian
Chronic kidney disease (CKD) is accompanied by cardiac fibrosis, hypertrophy, and dysfunction, which are commonly referred to as uremic cardiomyopathy. Our previous studies found that Na/K-ATPase ligands or 5/6th partial nephrectomy (PNx) induces cardiac fibrosis in rats and mice. The current study used in vitro and in vivo models to explore novel roles for microRNA in this mechanism of cardiac fibrosis formation. To accomplish this, we performed microRNA profiling with RT-qPCR based arrays on cardiac tissue from rats subjected to marinobufagenin (MBG) infusion or PNx...
March 2016: Physiological Genomics
https://www.readbyqxmd.com/read/26607049/early-detection-of-subclinical-uremic-cardiomyopathy-using-two-dimensional-speckle-tracking-echocardiography
#14
Noha Hassanin, Alkhateeb Alkemary
BACKGROUND: Overhydration has a deleterious effect on cardio myocytes. This study was designated to evaluate left ventricular (LV) systolic and diastolic dysfunction in patients with various stages of chronic kidney disease (CKD) using conventional, tissue Doppler and two-dimensional speckle tracking echocardiography (2DSTE). METHODS: Forty controls and 90 CKD patients, aged 49.3 ± 14 years old, were enrolled in the study. Patients were divided into 3 groups depending on their glomerular filtration rate...
April 2016: Echocardiography
https://www.readbyqxmd.com/read/26557394/acute-systolic-heart-failure-associated-with-complement-mediated-hemolytic-uremic-syndrome
#15
John L Vaughn, Jared M Moore, Spero R Cataland
Complement-mediated hemolytic uremic syndrome (otherwise known as atypical HUS) is a rare disorder of uncontrolled complement activation that may be associated with heart failure. We report the case of a 49-year-old female with no history of heart disease who presented with microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Given her normal ADAMSTS13 activity, evidence of increased complement activation, and renal biopsy showing evidence of thrombotic microangiopathy, she was diagnosed with complement-mediated HUS...
2015: Case Reports in Hematology
https://www.readbyqxmd.com/read/26093151/cb1-cannabinoid-receptor-antagonist-attenuates-left-ventricular-hypertrophy-and-akt-mediated-cardiac-fibrosis-in-experimental-uremia
#16
Chih-Yuan Lin, Yu-Juei Hsu, Shih-Che Hsu, Ying Chen, Herng-Sheng Lee, Shih-Hua Lin, Shih-Ming Huang, Chien-Sung Tsai, Chun-Che Shih
Cannabinoid receptor type 1 (CB1R) plays an important role in the development of myocardial hypertrophy and fibrosis-2 pathological features of uremic cardiomyopathy. However, it remains unknown whether CB1R is involved in the pathogenesis of uremic cardiomyopathy. Here, we aimed to elucidate the role of CB1R in the development of uremic cardiomyopathy via modulation of Akt signalling. The heart size and myocardial fibrosis were evaluated by echocardiography and immunohistochemical staining, respectively, in 5/6 nephrectomy chronic kidney disease (CKD) mice treated with a CB1R antagonist...
August 2015: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/25999962/alteration-of-cardiovascular-structure-and-function-in-patients-undergoing-peritoneal-dialysis
#17
Damir R Rebić, Senija R Rašić, Muamer D Dervišević, Aida H M Hamzić-Mehmedbašić, Alma M Muslimović, Edina H Hasanagić
AIMS: Cardiovascular alterations contribute to a high mortality rate in patients with end-stage renal disease (ESRD). The aims of the present study are to evaluate left ventricular (LV) function and common carotid artery (CCA) parameters and to determine risk factors associated with these changes in patients undergoing peritoneal dialysis (PD). METHODS: This longitudinal prospective study was conducted in 50 ESRD patients in whom PD had been initiated and who were observed for 18 months after the commencement of dialysis treatment, with echocardiography and CCA ultrasound parameter evaluation...
April 2015: Cardiorenal Medicine
https://www.readbyqxmd.com/read/25940851/the-relationship-between-volume-overload-in-end-stage-renal-disease-and-obstructive-sleep-apnea
#18
Maria-Eleni Roumelioti, Lee K Brown, Mark L Unruh
Obstructive sleep apnea (OSA) is common, underdiagnosed, and undertreated among patients with end-stage renal disease (ESRD). As in all cases, pathogenesis of OSA is related to repeated upper airway (UA) occlusion or narrowing, but in ESRD, additional contributory factors likely include uremic destabilization of central respiratory control and anatomic changes in the UA related to fluid status. Pulmonary congestion is common in acute and chronic kidney failure and is a consequence of cardiomyopathy and fluid overload, two potentially reversible risk factors...
September 2015: Seminars in Dialysis
https://www.readbyqxmd.com/read/25769628/diffuse-interstitial-fibrosis-and-myocardial-dysfunction-in-early-chronic-kidney-disease
#19
Nicola C Edwards, William E Moody, Mengshi Yuan, Manvir K Hayer, Charles J Ferro, Jonathan N Townend, Richard P Steeds
Early-stage chronic kidney disease (CKD) is an under-recognized highly prevalent cardiovascular (CV) risk factor. Despite a clustering of conventional atherosclerotic risk factors, it is hypothesized that nonatherosclerotic processes, including left ventricular (LV) hypertrophy and fibrosis, account for a significant excess of CV risk. This cross-sectional observational study of 129 age- (mean age 57±10 years) and gender-matched subjects examined: nondiabetic CKD stages 2 to 4 (mean glomerular filtration rate 50±22 ml/min/1...
May 1, 2015: American Journal of Cardiology
https://www.readbyqxmd.com/read/25731010/-congestive-heart-failure-in-patients-with-chronic-kidney-disease
#20
REVIEW
Mileta Poskurica, Dejan Petrović
Cardiovascular disorders are the most frequent cause of death (46-60%) among patients with advanced chronic renal failure (CRF), and on dialysis treatment. Uremic cardiomyopathy is the basic pathophysiologic substrate, whereas ischemic heart disease (IHD) and anemia are the most important contributing factors. Associated with well-know risk factors and specific disorders for terminal kidney failure and dialysis, the aforementioned factors instigate congestive heart failure (CHF). Suspected CHF is based on the anamnesis, clinical examination and ECG, while it is confirmed and defined more precisely on the basis of echocardiography and radiology examination...
November 2014: Srpski Arhiv za Celokupno Lekarstvo
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