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Sean McConachie, Sheila M Wilhelm, Pramodini B Kale-Pradhan
Biologic antagonists to tumor necrosis factor alpha (TNF- α) are effective medications and have become well established in the treatment of both Crohn's disease and ulcerative colitis. Biosimilar medications, which are medications deemed to be equivalent to reference biologic products in terms of clinical effectiveness, safety, pharmacokinetic analysis, and immunogenicity, have now been approved in inflammatory bowel diseases (IBD) based on indication exploration from clinical data in alternate disease states...
January 17, 2017: Expert Review of Clinical Pharmacology
Manish K Pandey, Gaurav Agarwal, Sandip M Kale, Josh Clevenger, Spurthi N Nayak, Manda Sriswathi, Annapurna Chitikineni, Carolina Chavarro, Xiaoping Chen, Hari D Upadhyaya, Manish K Vishwakarma, Soraya Leal-Bertioli, Xuanqiang Liang, David J Bertioli, Baozhu Guo, Scott A Jackson, Peggy Ozias-Akins, Rajeev K Varshney
Single nucleotide polymorphisms (SNPs) are the most abundant DNA sequence variation in the genomes which can be used to associate genotypic variation to the phenotype. Therefore, availability of a high-density SNP array with uniform genome coverage can advance genetic studies and breeding applications. Here we report the development of a high-density SNP array 'Axiom_Arachis' with 58 K SNPs and its utility in groundnut genetic diversity study. In this context, from a total of 163,782 SNPs derived from DNA resequencing and RNA-sequencing of 41 groundnut accessions and wild diploid ancestors, a total of 58,233 unique and informative SNPs were selected for developing the array...
January 16, 2017: Scientific Reports
Patricia S Ault, John Rose PharmD, Lisa A Nodzon PhD, Elizabeth S Kaled
The past decade has witnessed great advances in the treatment of chronic myeloid leukemia (CML), brought about in large part by the development of BCR-ABL tyrosine kinase inhibitors (TKIs). Bosutinib joins the armamentarium of approved TKIs for the treatment of chronic phase (CP), accelerated phase (AP), and blast phase (BP) Philadelphia chromosome (Ph)-positive CML resistant to or intolerant of prior therapy. Bosutinib has an adverse-event (AE) profile distinct from that of other TKIs. Diarrhea is the predominant toxicity associated with bosutinib treatment; other commonly reported nonhematologic AEs include rash and liver enzyme elevations...
March 2016: Journal of the Advanced Practitioner in Oncology
George F Antonious, Eric T Turley, Mutari Abubakari, John C Snyder
The persistence and fate of chlorpyrifos and its two metabolites, chlorpyrifos-oxon and the 3, 5, 6-trichloro-2-pyridinol (TCP) break-down product were investigated on kale and collard leaves under field conditions. A simultaneous extraction and quantification procedure was developed for chrorpyrifos and its two main metabolites. Residues of chlorpyrifos, chlorpyrifos oxon, and TCP were determined using a gas chromatograph (GC) equipped with an electron capture detector (GC/ECD). Chlorpyrifos metabolites were detectable up to 23 days following application...
January 12, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
Matthew S Thiese, Richard J Hanowski, Stefanos N Kales, Richard J Porter, Gary Moffitt, Nan Hu, Kurt T Hegmann
OBJECTIVE: This study aims to quantify the crash risk for truck drivers with multiple comorbid medical conditions, after adjusting for confounders. METHODS: This retrospective cohort of 38,184 drivers evaluated concomitant medical conditions and subsequent crash data between January 1, 2005, and October 31, 2012. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated for any cause and preventable crashes of varying severity. RESULTS: Drivers with three or more medical conditions had a significantly increased risk of preventable Department of Transportation (DOT) reportable crashes (HR = 2...
January 10, 2017: Journal of Occupational and Environmental Medicine
S S Muttagi, B R Patil, A S Godhi, D K Arora, S R Hallikerimath, A D Kale
AIM: Lymph node yield (LNY) is a valid marker of prognosis in oral cancer. Precise estimation of LNY in Indian patients with T3/T4 gingivobuccal sulcus squamous cell carcinoma (GBS-SCC) has not been well documented. Hence, the primary objective of the study was to determine the LNY in patients with T3/T4 SCC of mandibular GBS, and the secondary objective was to study the association of LNY with clinicopathological factors such as tumor thickness, histological differentiation, number of positive nodes, and extracapsular spread (ECS)...
April 2016: Indian Journal of Cancer
Eyyup Karahan, Omer Karti, Aslı Koskderelioglu, Dilek Top Karti, Murat Uyar, Murat Yildirim Kale, Muhtesem Gedizlioglu
To evaluate the value of pupil cycle time (PCT) as an indicator of optic nerve dysfunction in patients with multiple sclerosis (MS), 42 patients with MS and 35 control subjects were included to the study. Patients with MS with a history of ON were accepted as group 1, without a history of ON as group 2 and healthy control subjects as group 3. Groups were compared with Chi-square and one-way ANOVA tests. Correlations of PCT results with age, best corrected visual acuity, duration of MS, visual field (VF) test, visual evoked potential (VEP) latans, retinal nerve fiber layer (RNFL), and ganglion cell layer-inner plexiform layer (GCL-IPL) thicknesses were analyzed...
January 4, 2017: Acta Neurologica Belgica
Tejraj P Kale, Arjun Gurmeet Singh, Pushpak Shah
Cutaneous lymphoid hyperplasia (CLH) is a cutaneous pseudolymphoma with a worldwide distribution, equally affecting all races and ethnic groups. Due to its vast array of characteristics, it is most often missed in the differential diagnosis of firm to soft lumps on the head and neck. A systematic approach to the workup and diagnosis along with treatment of such lesions is discussed in this article. A 20-year-old Asian Indian female presented to our Oral and Maxillofacial unit with a lump on the left side of her forehead for 1 month...
December 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
Fatma Deniz Uzuner, Duygu Öztürk, Selin Kale Varlık
OBJECTIVE: To evaluate the effects of combined rapid maxillary expansion (RME) and face mask (FM) therapy during the mixed dentition period on the dental arch length in patients with skeletal Class III malocclusion. STUDY DESIGN: We evaluated pre- and post-treatment orthodontic models of 52 patients (25 girls, 27 boys) aged 8-12 years with skeletal Class III malocclusion(ANB<0) accompanied by maxillary transverse deficiency and retrognatism treated by bonded RME-FM therapy for a mean duration of 8 months...
2017: Journal of Clinical Pediatric Dentistry
Devkumar Rengaraja, Mohan Jagade, Vitthal Kale, Anoop Attakil, Rajesh Kar, Arpita Singhal, Karthik Rao, Pallavi Gupta
INTRODUCTION: "As the septum goes, so goes the nose". A well-known phrase by Maurice Cottle forms the pillar of septoplasty. Since the inception of septal surgeries, numerous methods of septoplasty have been described. But, if not performed meticulously, may lead to deformity. For a successful surgery, understanding the anatomy and addressing the anterior nasal spine and maintaining the tip integrity is vital. AIM: To study the outcomes of "ROUND ABOUT technique" to correct deviated nasal septum which focuses on the importance of anterior spine and hence maintain the tip integrity...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
R Bisht, S Kale, G Natanasabapathi, M Singh, D Agarwal, G Rath, P Julka, P Kumar, S Thulkar, A Garg, B Sharma
PURPOSE: The purpose of this study is to estimate technical treatment accuracy in fractionated stereotactic radiosurgery (fSRS) using extend system (ES) of Gamma Knife (GK). METHODS: The fSRS with GK relies on a patient specific re-locatable immobilization system. The reference treatment position is estimated using a digital probe and a repositioning check tool (RCT). The "calibration values" of RCT apertures were compared with measured values on RCT-QA tool to evaluate the standard error (SE) associated with RCT measurements...
June 2016: Medical Physics
Donovan T Maust, Jo Anne Sirey, Helen C Kales
OBJECTIVE: The study compared distress levels among two groups of older adults who had been newly prescribed an antidepressant by their primary care physician, those with major depressive disorder (MDD) and those without MDD. METHODS: This analysis used a convenience sample of participants (N=231) who had been newly prescribed an antidepressant in a randomized controlled trial of a program to improve antidepressant adherence and depression outcomes among older adults (≥55)...
January 3, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
Mingdan Deng, Hongmei Qian, Lili Chen, Bo Sun, Jiaqi Chang, Huiying Miao, Congxi Cai, Qiaomei Wang
The effects of pre-harvest red light irradiation on main healthy phytochemicals as well as antioxidant activity of Chinese kale sprouts during postharvest storage were investigated. 6-day-old sprouts were treated by red light for 24h before harvest and sampled for further analysis of nutritional quality on the first, second and third day after harvest. The results indicated that red light exposure notably postponed the degradation of aliphatic, indole, and total glucosinolates during postharvest storage. The vitamin C level was remarkably higher in red light treated sprouts on the first and second day after harvest when compared with the control...
May 1, 2017: Food Chemistry
Molly Sweeney-Magee, Dimitra Kale, Simon Galton, Andrea Hamill, Hazel Gilbert
BACKGROUND: Implementation fidelity refers to the extent to which a proposed intervention is enacted as designed and is necessary to determine how much the intervention in question is the primary mechanism in any changes observed. Start2quit was a randomised controlled trial that aimed to improve attendance at the English Stop Smoking Service (SSS). The complex intervention combining computer-tailored personal risk letters and no-commitment ("taster") sessions aimed at encouraging attendance at the SSS doubled attendance at the SSS and significantly increased abstinence rates, although attendance and abstinence varied between participating SSSs...
December 28, 2016: Implementation Science: IS
Abhijit Kale, Gerard Rimesso, Nicholas E Baker
Drosophila imaginal disc cells exhibit preferred cell division orientations according to location within the disc. These orientations are altered if cell death occurs within the epithelium, such as is caused by cell competition or by genotypes affecting cell survival. Both normal cell division orientations, and their orientations after cell death, depend on the Fat-Dachsous pathway of planar cell polarity (PCP). The hypothesis that cell death initiates a planar polarity signal was investigated. When clones homozygous for the pineapple eye (pie) mutation were made to initiate cell death, neither Dachsous nor Fat was required in pie cells for the re-orientation of nearby cells, indicating a distinct signal for this PCP pathway...
2016: PloS One
Vikas K Singh, Aamir W Khan, Rachit K Saxena, Pallavi Sinha, Sandip M Kale, Swathi Parupalli, Vinay Kumar, Annapurna Chitikineni, V Suryanarayana, C V Sameer Kumar, Mamta Sharma, G Anuradha, K N Yamini, S Muniswamy, Rajeev K Varshney
Identification of candidate genomic regions associated with target traits using conventional mapping methods is challenging and time-consuming. In recent years, a number of single nucleotide polymorphisms (SNPs) based mapping approaches have been developed and used for identification of candidate/putative genomic regions. However, in the majority of these studies, insertion-deletion (Indel) mutations were largely ignored. For efficient use of Indels in mapping target traits, we propose Indel-seq approach, which is a combination of whole genome re-sequencing (WGRS) and bulked segregant analysis (BSA) and relies on the Indel frequencies in a given germplasm set...
December 27, 2016: Plant Biotechnology Journal
Rongfang Guo, Yanping Deng, Zhongkai Huang, Xiaodong Chen, Xu XuHan, Zhongxiong Lai
MicroRNAs (miRNAs) are important for plant development including seed formation, dormancy, and germination, as well as seedling establishment. The Brassica vegetable seedling establishment stage influences the development of high quality seedlings, but also affects the nutrient content of sprouts. Chinese kale (Brassica alboglabra) seedlings at different growth stages were used to construct two small-RNA (sRNA) libraries. We comprehensively analyzed the miRNAs in 2- and 9-day-old seedlings. An average of 11,722,490 clean reads were generated after removing low-quality reads and adapter contaminants...
2016: Frontiers in Plant Science
Lauren B Gerlach, Helen C Kales, Donovan T Maust, Claire Chiang, Claire Stano, Hae Mi Choe, Kara Zivin
OBJECTIVES: In 2011, the U.S. Food and Drug Administration (FDA) issued a safety announcement cautioning providers against prescribing citalopram above 40 mg per day given concerns for QT prolongation. We assessed the impact of a health system quality improvement initiative to identify patients taking higher than the recommended dose of citalopram. DESIGN: Retrospective cohort study. SETTING: Nine primary care clinics within the University of Michigan from March 2012 to February 2013...
November 18, 2016: American Journal of Geriatric Psychiatry
Lauren B Gerlach, Helen C Kales
No abstract text is available yet for this article.
December 7, 2016: American Journal of Geriatric Psychiatry
Nikita Shekhar Sawantdesai, Pravin Popatrao Kale, Jay Savai
CONTEXT: Anxiety disorders are chronic, common, and often comorbid. There is an unmet need in its treatment. Aripiprazole and hydroxyzine are well-known therapeutic options used as monotherapy in clinics. They have different mechanisms and site of actions. AIM: The objective of the present study was to evaluate the anxiolytic effect of aripiprazole and hydroxyzine in combination. MATERIALS AND METHODS: Swiss albino mice (male) received treatment of 5% of Tween 80 in 0...
September 2016: Journal of Basic and Clinical Pharmacy
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