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https://www.readbyqxmd.com/read/29161539/home-is-where-the-future-is-the-brightfocus-foundation-consensus-panel-on-dementia-care
#1
Quincy M Samus, Constantine G Lyketsos, Betty Smith Black, Diane Bovenkamp, Michael Buckley, Christopher Callahan, Karen Davis, Laura N Gitlin, Nancy Hodgson, Deirdre Johnston, Helen C Kales, Michele Karel, John Jay Kenney, Shari M Ling, Maï Panchal, Melissa Reuland, Amber Willink
INTRODUCTION: A national consensus panel was convened to develop recommendations on future directions for home-based dementia care (HBDC). METHODS: The panel summarized advantages and challenges of shifting to HBDC as the nexus of care and developed consensus-based recommendations. RESULTS: The panel developed five core recommendations: (1) HBDC should be considered the nexus of new dementia models, from diagnosis to end of life in dementia; (2) new payment models are needed to support HBDC and reward integration of care; (3) a diverse new workforce that spans the care continuum should be prepared urgently; (4) new technologies to promote communication, monitoring/safety, and symptoms management must be tested, integrated, and deployed; and (5) targeted dissemination efforts for HBDC must be employed...
November 18, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29149100/bcl-2-family-proteins-changing-partners-in-the-dance-towards-death
#2
REVIEW
Justin Kale, Elizabeth J Osterlund, David W Andrews
The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible release of intermembrane space proteins, subsequent caspase activation and apoptosis. The affinities and relative abundance of the BCL-2 family proteins dictate the predominate interactions between anti-apoptotic and pro-apoptotic BCL-2 family proteins that regulate MOMP. We highlight the core mechanisms of BCL-2 family regulation of MOMP with an emphasis on how the interactions between the BCL-2 family proteins govern cell fate...
November 17, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29146249/composition-of-lactic-acid-bacteria-during-spontaneous-curly-kale-brassica-oleracea-var-sabellica-fermentation
#3
Magdalena Michalak, Klaudia Gustaw, Adam Waśko, Magdalena Polak-Berecka
The present work is the first report on spontaneous fermentation of curly kale and characteristics of autochthonous lactic acid bacteria (LAB). Our results indicate that curly kale fermentation is the new possibility of the technological use of this vegetable. Bacteria representing ten different species were isolated from three phases of curly kale fermentation and identified by MALDI-TOF mass spectrometry and 16S rRNA gene sequencing. Among them, four species were identified as Lactobacillus spp. (Lb. plantarum 332, Lb...
January 2018: Microbiological Research
https://www.readbyqxmd.com/read/29136629/modified-alcohol-formalin-cell-block-technique-in-head-and-neck-pathology-diagnosis
#4
Karishma M Desai, Punnya V Angadi, Alka D Kale, Seema Hallikerimath
OBJECTIVES: Cell block preparation is a recognized technique in histopathological diagnosis. This technique aids in maintaining an intact architecture and reducing the diagnostic errors associated with fine-needle aspiration cytology. Numerous techniques have been put forth, but the need for an optimal technique for routine use in the laboratory still persists. The aim of our study was to establish a cell block technique which aids in the accurate diagnosis of head and neck pathology...
November 15, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/29136366/use-of-an-efficient-measurement-uncertainty-approach-to-compare-room-temperature-and-cryogenic-sample-processing-in-the-analysis-of-chemical-contaminants-in-foods
#5
Lijun Han, Steven J Lehotay, Yelena Sapozhnikova
In this study, analytical results were compared when using different approaches to bulk food sample comminution, consisting of a vertical chopper (Blixer(®)) at room temperature and at dry ice cryogenic conditions, followed by further subsample processing (20 g) using liquid nitrogen cryogenic conditions (cryomill). Analysis of the 43 targeted spiked and incurred contaminants in a food mixture consisting of equal parts orange, apple, kale, salmon, and croaker involved QuEChERS with automated mini-column solid-phase extraction (known as ITSP) cleanup followed by low pressure gas chromatography - tandem mass spectrometry (LPGC-MS/MS)...
November 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29134675/analytical-approach-dissipation-pattern-and-risk-assessment-of-pesticide-residue-in-green-leafy-vegetables-a-comprehensive-review
#6
REVIEW
Waziha Farha, A M Abd El-Aty, Md Musfiqur Rahman, Ji Hoon Jeong, Ho-Chul Shin, Jing Wang, Sung Shik Shin, Jae-Han Shim
The category of "leafy vegetables" comprises a wide range of plants, including cabbage, lettuce, leeks, spinach, Swiss chard, and kale, and it forms a significant component of the human diet. Typically, leafy vegetables are low in calories and fat, are great sources of vitamins, protein, dietary fibre, minerals (including iron, calcium, and nitrates), and are rich in phytochemicals. To counter the impact of pests on vegetables, a broad variety of pesticides is used. Because of their large surface areas, leafy vegetables are expected to have high residual pesticide levels...
November 14, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29133192/maternal-micronutrients-omega-3-fatty-acids-and-gene-expression-of-angiogenic-and-inflammatory-markers-in-pregnancy-induced-hypertension-rats
#7
Nisha Kemse, Deepali Sundrani, Anvita Kale, Sadhana Joshi
BACKGROUND AND AIMS: Preeclampsia is a disorder of pregnancy and is associated with inflammation and altered angiogenesis. The present study examines the effect of micronutrient and omega-3 fatty acid supplementation (individual, as well as combined) on genes involved in inflammation and angiogenesis, as well as global DNA methylation levels in a pregnancy induced hypertension (PIH) rat model. METHODS: Pregnant Wistar rats were randomly assigned to six dietary groups: control, PIH (Pregnancy induced hypertension) Induced; PIH Induced with micronutrient supplements with vitamin B12 (PIHB), folate (PIHF), omega-3 fatty acid (PIHO), and combined supplementation (PIHC) (micronutrients and omega-3 fatty acids)...
November 10, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29121474/outcomes-following-video-assisted-thoracoscopic-lobectomy-versus-open-lobectomy-for-early-stage-lung-cancer-in-older-adults
#8
Nicole Ezer, Minal Kale, Keith Sigel, Sameer Lakha, Grace Mhango, Emily Goodman, Daniel Nicastri, Scott Swanson, Alfred Neugut, Juan P Wisnivesky
RATIONALE: Video-assisted thoracoscopic surgery and open lobectomy are both standard of care for treatment of early stage NSCLC because of equivalent long-term survival. OBJECTIVE: To evaluated whether the improved peri-operative outcomes associated with VATS are explained by differences in case volume and specialty training. METHODS: We analyzed the Surveillance, Epidemiology and End Results-Medicare linked registry to identify stage I-II NSCLC in patients above 65 years of age...
November 9, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29114913/a-retrospective-analysis-of-cardiometabolic-health-in-a-large-cohort-of-truck-drivers-compared-to-the-american-working-population
#9
Matthew S Thiese, Richard J Hanowski, Gary Moffitt, Stefanos N Kales, Richard J Porter, Brenden Ronna, Natalie Hartenbaum, Kurt T Hegmann
BACKGROUND: Truck drivers face many health challenges, including lifestyle, diet, inactivity, stressors, and social support. METHODS: A repeated cross-sectional analysis compared 88,246 truck drivers with data from (n = 11 918) the National Health and Nutrition Examination Survey (NHANES). Trends over time for body mass index (BMI), high blood pressure, diabetes mellitus, heart disease, and sleep disorders were analyzed, adjusting for potential confounders...
November 8, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/29107024/relaxant-effect-of-the-prostacyclin-analogue-iloprost-on-isolated-human-radial-artery-an-approach-for-the-reversal-of-graft-spasm
#10
Ersoy Engin, F İlkay Alp Yildirim, Deniz Kalelі Durman, Suat Nail Ömeroğlu, Deniz Göksedef, Önder Teskіn, Ozan Onur Balkanay, Gökhan İpek, B Sönmez Uydeş Doğan
Radial artery graft spasm in the perioperative or postoperative period of coronary bypass surgery necessitates urgent treatment due to risk of graft failure and mortality. Herein, we evaluated the effect of iloprost, a prostacyclin (PGI2) analogue, against the contractions produced by noradrenaline and potassium chloride on isolated human radial artery. Following the determination of endothelial and vascular relaxing capacities of the arteries, iloprost (10(-9)M-10(-6)M) was cumulatively applied on rings precontracted submaximally with the spasmogens...
October 26, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29102560/can-a-clinician-scientist-training-program-develop-academic-orthopaedic-surgeons-one-program-s-thirty-year-experience
#11
Aaron M Brandt, Samantha A Rettig, Neel K Kale, Joseph D Zuckerman, Kenneth A Egol
BACKGROUND: Clinician-scientist numbers have been stagnant over the past few decades despite awareness of this trend. Interventions attempting to change this problem have been seemingly ineffective, but research residency positions have shown potential benefit. OBJECTIVE: We sought to evaluate the effectiveness of a clinician-scientist training program (CSTP) in an academic orthopedic residency in improving academic productivity and increasing interest in academic careers...
October 25, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29084388/antiobesity-effect-of-exopolysaccharides-isolated-from-kefir-grains
#12
Juha Lim, Madhuvanti Kale, Dong-Hyeon Kim, Hong-Seok Kim, Jung-Whan Chon, Kun-Ho Seo, Hyeon Gyu Lee, Wallace Yokoyama, Hyunsook Kim
Physiological properties of water-soluble exopolysaccharides (EPS) and residues after EPS removal (Res) from the probiotic kefir were determined in high-fat (HF) diet-fed C57BL/6J mice. EPS solutions showed rheological properties and lower viscosity compared to those of β-glucan (BG). EPS significantly suppressed the adipogenesis of 3T3-L1 preadipocytes in a dose-dependent manner. Mice were fed HF diets containing 5% EPS, 5% BG, 8% Res, or 5% microcrystalline cellulose (control) for 4 weeks. Compared with the control, EPS supplementation significantly reduced HF diet-induced body weight gain, adipose tissue weight, and plasma very-low-density lipoprotein cholesterol concentration (P < 0...
November 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29069783/tle1-inhibits-anoikis-and-promotes-tumorigenicity-in-human-lung-cancer-cells-through-zeb1-mediated-e-cadherin-repression
#13
Xin Yao, Tri Pham, Brandi Temple, Selena Gray, Cornita Cannon, Camry Hardy, Kamari Fletcher, Shubha Kale Ireland, Ahamed Hossain, Renwei Chen, Asim B Abdel-Mageed, Hector Biliran
The Transducin-like enhancer of split 1 (TLE1) corepressor protein is overexpressed in human lung tumors and is a putative lung-specific oncogene. However, the molecular mechanism underlying its oncogenic function remains to be delineated. Here, we report an important role of TLE1 in promoting lung tumorigenesis by a mechanism involving induction of anoikis resistance. Using the human lung adenocarcinoma A549 and immortalized bronchial epithelial BEAS-2B cell lines, we observed that TLE1 inhibits anoikis through transcriptional repression of E-cadherin gene...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29069139/elemental-composition-of-vegetables-cultivated-over-coal-mining-waste
#14
Jairo J Zocche, Paula Rohr, Adriani P Damiani, Daniela D Leffa, Miriam C Martins, Caroline M Zocche, Karina O Teixeira, Gabriela D Borges, Maiellen M DE Jesus, Carla E I Dos Santos, Johnny F Dias, Vanessa M DE Andrade
We assessed elemental composition of the liver in mice subjected to one-time or chronic consumption of the juice of vegetables cultivated in a vegetable garden built over deposits of coal waste. Lactuca sativa L. (lettuce), Beta vulgaris L. (beet), Brassica oleracea L. var. italica (broccoli) and Brassica oleracea L. var. acephala (kale) were collected from the coal-mining area and from a certified organic farm (control). Elemental composition was analyzed by particle-induced X-ray emission (PIXE) method. Concentrations of Mg, S, and Ca of mice subjected to one-time consumption of broccoli and concentrations of these same elements plus Si of mice receiving kale were higher in the coal-mining area...
October 23, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29068560/extremely-vivid-highly-transparent-and-ultrathin-quantum-dot-light-emitting-diodes
#15
Moon Kee Choi, Jiwoong Yang, Dong Chan Kim, Zhaohe Dai, Junhee Kim, Hyojin Seung, Vinayak S Kale, Sae Jin Sung, Chong Rae Park, Nanshu Lu, Taeghwan Hyeon, Dae-Hyeong Kim
Displaying information on transparent screens offers new opportunities in next-generation electronics, such as augmented reality devices, smart surgical glasses, and smart windows. Outstanding luminance and transparency are essential for such "see-through" displays to show vivid images over clear background view. Here transparent quantum dot light-emitting diodes (Tr-QLEDs) are reported with high brightness (bottom: ≈43 000 cd m(-2) , top: ≈30 000 cd m(-2) , total: ≈73 000 cd m(-2) at 9 V), excellent transmittance (90% at 550 nm, 84% over visible range), and an ultrathin form factor (≈2...
October 25, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29068080/electrothermal-enrichment-of-submicron-particles-in-an-insulator-based-dielectrophoretic-microdevice
#16
Akshay Kale, Le Song, Xinyu Lu, Liandong Yu, Guoqing Hu, Xiangchun Xuan
Insulator-based dielectrophoresis (iDEP) exploits in-channel hurdles and posts etc. to create electric field gradients for various particle manipulations. However, the presence of such insulating structures also amplifies the Joule heating in the fluid around themselves, leading to both temperature gradients and electrothermal flow. These Joule heating effects have been previously demonstrated to weaken the dielectrophoretic focusing and trapping of microscale and nanoscale particles. We find that the electrothermal flow vortices are able to entrain submicron particles for a localized enrichment near the insulating tips of a ratchet microchannel...
October 25, 2017: Electrophoresis
https://www.readbyqxmd.com/read/29066038/assessing-responsiveness-of-health-systems-to-drug-safety-warnings
#17
Lauren B Gerlach, Hyungjin Myra Kim, Matheos Yosef, Anne E Sales, Claire Stano, Helen C Kales, Kara Zivin
OBJECTIVE: In 2011-2012 the U.S. Food and Drug Administration (FDA) issued safety announcements cautioning providers against prescribing high doses of citalopram given concerns for QT prolongation. The authors evaluated Veterans Affairs (VA) national trends in citalopram use and dose compared with alternative antidepressants after the FDA warnings. METHODS: Time series analyses estimated the effect of the FDA warnings on citalopram and other antidepressant across three periods: before the first FDA warning in August 2011, after the 2011 FDA warning until the second warning in March 2012, and after the 2012 FDA warning...
September 28, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29063630/isolation-and-characterization-of-multi-drug-resistant-leclercia-species-from-animal-clinical-case
#18
Mamta Choudhary, Binod Kumar Choudhary, Smita Bhoyar, Satyajit B Kale, S P Chaudhari, B C Bera, Ashok Jain, S B Barbuddhe
Leclercia adecarboxylata, a Gram-negative bacillus of family Enterobacteriaceae, is an uncommonly identified pathogen isolated from environmental and clinical specimens. Most of the human infections are polymicrobial and commonly occur in immunocompromised hosts, although nosocomial infections in immunocompetent hosts have been documented. Here, we describe the case of isolation of Leclercia species as polymicrobial infection from bovine suffering from respiratory distress in Chhattisgarh state of India. The isolates were identified by their phenotypes, 16S rDNA sequencing and by MALDI TOF-MS...
October 24, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29058468/screening-and-identification-of-major-phytochemical-compounds-in-seeds-sprouts-and-leaves-of-tuscan-black-kale-brassica-oleracea-l-ssp-acephala-dc-var-sabellica-l
#19
Lucia Giorgetti, Gianluca Giorgi, Edoardo Cherubini, Pier Giovanni Gervasi, Clara Maria Della Croce, Vincenzo Longo, Lorenza Bellani
We report the spectrophotometric determination of total polyphenols, flavonoids, glucosinolates and antioxidant activity in seeds, seedlings and leaves of Tuscan black kale. The highest content of phytochemicals was observed in 10 days sprouts and antioxidant activity was maximum in 2, 4 days seedlings. Identification and characterisation of phytochemicals were performed by mass spectrometry (MS), high resolution and tandem MS with electrospray ionisation mode. Low-molecular-weight metabolites were evidenced in seeds while metabolites at high m/z range were detected in cotyledons and leaves...
October 23, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29055544/dry-matter-intake-body-condition-score-and-grazing-behavior-of-nonlactating-pregnant-dairy-cows-fed-on-kale-or-grass-once-versus-twice-during-winter
#20
I Rugoho, G R Edwards
The objective of this study was to examine the effect of wintering pregnant, nonlactating dairy cows outdoors on either kale or grass, fed in 1 [11 kg of dry matter (DM) of kale or grass + 3 kg of DM of baled barley straw offered in the morning] or 2 allocations (5.5 kg of DM of kale or grass grazed + 1.5 kg of DM barley straw offered morning and afternoon) per day. The body condition score (BCS) gain over the 47-d winter feeding period was higher for grass-fed (0.5 BCS units) than kale-fed cows (0.3 BCS units), but was unaffected by feeding frequency...
October 18, 2017: Journal of Dairy Science
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