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https://www.readbyqxmd.com/read/28730528/sulforaphane-promotes-mitochondrial-protection-in-sh-sy5y-cells-exposed-to-hydrogen-peroxide-by-an-nrf2-dependent-mechanism
#1
Marcos Roberto de Oliveira, Flávia de Bittencourt Brasil, Cristina Ribas Fürstenau
Sulforaphane (SFN; C6H11NOS2) is an isothiocyanate found in cruciferous vegetables, such as broccoli, kale, and radish. SFN exhibits antioxidant, anti-apoptotic, anti-tumor, and anti-inflammatory activities in different cell types. However, it was not previously demonstrated whether and how this natural compound would exert mitochondrial protection experimentally. Therefore, we investigated here the effects of a pretreatment (for 30 min) with SFN at 5 μM on mitochondria obtained from human neuroblastoma SH-SY5Y cells exposed to hydrogen peroxide (H2O2) at 300 μM for 24 h...
July 20, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28730203/growth-study-of-hierarchical-ag3po4-laco3oh-heterostructures-and-their-efficient-photocatalytic-activity-for-rhb-degradation
#2
Virendrakumar G Deonikar, Santosh S Patil, Mohaseen S Tamboli, Jalindar D Ambekar, Milind V Kulkarni, Rajendra P Panmand, Govind G Umarji, Manish D Shinde, Sunit B Rane, Nagegownivari R Munirathnam, Deepak R Patil, Bharat B Kale
We have demonstrated the synthesis of Ag3PO4/LaCO3OH (APO/LCO) heterostructured photocatalysts by an in situ wet chemical method. From pre-screening evaluations of photocatalysts with APO/(x wt% LCO) composites with mass ratios of x = 5, 10, 15, 20, 25 and 30 wt%, we found that the APO/LCO (20 wt%) exhibited a superior photocatalytic activity for organic pollutant remediation. Therefore, an optimised photocatalyst APO/LCO (20 wt%) is selected for the present study and we investigate the effect of a mixed solvent system (H2O:THF) on the morphology, which has a direct effect on the photocatalytic performance...
July 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28727377/laparoscopic-pectopexy-initial-experience-of-single-center-with-a-new-technique-for-apical-prolapse-surgery
#3
Ahmet Kale, Alper Biler, Hasan Terzi, Taner Usta, Ebru Kale
OBJECTIVE: To share our first experience with laparoscopic pectopexy, a new technique for apical prolapse surgery, and to evaluate the feasibility of this technique. MATERIALS AND METHODS: Seven patients with apical prolapse underwent surgery with laparoscopic pectopexy. The lateral parts of the iliopectineal ligament were used for a bilateral mesh fixation of the descended structures. The medical records of the patients were reviewed, and the short-term clinical outcomes were analyzed...
June 14, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28716471/clinical-significance-of-preoperative-serum-c-reactive-protein-in-oral-squamous-cell-carcinoma
#4
S Acharya, J Kale, K Hallikeri, V Anehosur, D Arnold
C-reactive protein (CRP) is an index of systemic inflammation. However, CRP is not usually assessed preoperatively. Hence the study intended to evaluate the preoperative serum CRP levels in oral squamous cell carcinoma (OSCC) patients and to analyse its relationship with the clinicopathologic characteristics. CRP values for 60 OSCCs and 30 healthy controls were evaluated using a CRP assessment kit and spectrophotometer. The Mann-Whitney U test, χ(2) test, receiver operating characteristic (ROC) curve analysis, and logistic regression were applied...
July 14, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28715875/acute-orexigenic-effect-of-agmatine-involves-interaction-between-central-%C3%AE-2-adrenergic-and-gabaergic-receptors
#5
Brijesh Gulabrao Taksande, Omi Sharma, Manish Manohar Aglawe, Mayur Bhimrao Kale, Dinesh Yugraj Gawande, Milind Janraoji Umekar, Nandkishor Ramdas Kotagale
Agmatine and GABA have been abundantly expressed in brain nuclei involved in regulation of energy homeostasis and promoting stimulation of food intake in rodents. However, their mutual interaction, if any, in the elicitation of feeding behavior is largely remains unclear. The current study provides experimental evidence for the possible interaction of agmatine, adrenergic and GABAergic systems in stimulation of feeding in satiated rats. Satiated rats fitted with intracerebroventricular (i.c.v.) cannulae and were administered agmatine, alone or jointly with (a) GABAA receptor agonist, muscimol, diazepam or antagonist bicuculline and flumazenil, GABAA positive modulator, allopregnanolone or negative modulator of GABAA receptor, dehydroepiandrosterone (b) In view of the high affinity of agmatine for α2-adrenoceptors and the close association between α2-adrenoceptors and GABAergic system, the effect of their modulators on feeding elicited by agmatine/GABAergic agonists were also examined...
July 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28710052/rationale-and-design-of-feeding-america-s-bravest-mediterranean-diet-based-intervention-to-change-firefighters-eating-habits-and-improve-cardiovascular-risk-profiles
#6
Mercedes Sotos-Prieto, Sean B Cash, Costas Christophi, Sara Folta, Steven Moffatt, Carolyn Muegge, Maria Korre, Dariush Mozaffarian, Stefanos N Kales
Among US firefighters, cardiovascular disease is the leading cause of on-duty death. Poor diet contributes to this burden, but effective strategies to encourage healthy eating in the fire service are not established. "Feeding America's Bravest" motivates firefighters and their families to modify their food culture and reduce cardiometabolic risk profiles by adopting Mediterranean diet principles. Feeding America's Bravest is a cluster-randomized, controlled trial within the 44 stations of the Indianapolis Fire Department, including about 1000 firefighters...
July 11, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28705818/intracranial-perishunt-catheter-fluid-collections-with-edema-a-sign-of-shunt-malfunction-correlation-of-ct-mri-and-nuclear-medicine-findings
#7
H A Kale, A Muthukrishnan, S V Hegde, V Agarwal
Fluid collections with edema along the intracranial tract of ventriculoperitoneal shunt catheters in adults are rare and are more frequently seen in children. The imaging appearance of these fluid collections is frequently confusing and presents a diagnostic dilemma. We present 6 cases of adult patients noted to have collections with edema along the tract of ventriculoperitoneal shunt catheters. To our knowledge, there are no previous studies correlating the CT/MR imaging findings with nuclear medicine scans in this entity...
July 13, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28696544/rheology-and-microstructure-of-gels-based-on-wheat-arabinoxylans-enzymatically-modified-in-arabinose-to-xylose-ratio
#8
Jorge A Marquez-Escalante, Elizabeth Carvjal-Millan, Madhav P Yadav, Madhuvanti Kale, Agustín Rascon-Chu, Alfonso A Gardea, Elisa Valenzuela-Soto, Yolanda L Lopez-Franco, Jaime Lizardi-Mendoza, Craig B Faulds
BACKGROUND: Arabinoxylans (AX) are polysaccharides constituted by a backbone of xyloses with arabinose substituents ester-linked to ferulic acid (FA). The arabinose to xylose ratio (A/X) in AX may vary from 0.3 to 1.1. AX form covalent gels by cross-linking of FA but physical interactions between AX chains also contribute to the network formation. The objective of this study was to investigate the rheological and microstructural characteristics of gels based on AX enzymatically modified in A/X...
July 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28683194/non-resonant-and-local-field-effects-in-peptidic-nanostructures-bearing-oligo-p-phenylenevinylene-units
#9
Herdeline Ann M Ardoña, Tejaswini S Kale, Alyssa Ertel, John D Tovar
Peptide nanostructures with built-in electronic functions offer a new platform for biomaterial science. In this report, we interrogate the influences of the immediate peptide environment around oligo(p¬-phenylenevinylene) (OPV3) electronic units embedded within one-dimensional peptide nanostructures on the resulting photophysics as assessed by UV-vis, photoluminescence (PL) and circular dichroism spectroscopies. To do so, we studied peptide-core-peptide molecules where the core was either OPV3 or an aliphatic n-decyl chain...
July 6, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28680435/molecular-characterization-of-myb28-involved-in-aliphatic-glucosinolate-biosynthesis-in-chinese-kale-brassica-oleracea-var-alboglabra-bailey
#10
Ling Yin, Hancai Chen, Bihao Cao, Jianjun Lei, Guoju Chen
Glucosinolates are Brassicaceae-specific secondary metabolites that act as crop protectants, flavor precursors, and cancer-prevention agents, which shows strong evidences of anticarcinogentic, antioxidant, and antimicrobial activities. MYB28, the R2R3-MYB28 transcription factor, directly activates genes involved in aliphatic glucosinolate biosynthesis. In this study, the MYB28 homology (BoaMYB28) was identified in Chinese kale (Brassica oleracea var. alboglabra Bailey). Analysis of the nucleotide sequence indicated that the cDNA of BoaMYB28 was 1257 bp with an ORF of 1020 bp...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28671424/nonalcoholic-fatty-liver-disease-identifying-patients-at-risk-of-inflammation-or-fibrosis
#11
Amimi S Osayande, Neelima Kale
No abstract text is available yet for this article.
June 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28670916/gamma-irradiation-affects-the-total-phenol-anthocyanin-and-antioxidant-properties-in-three-different-persian-pistachio-nuts
#12
Mohammad Akbari, Mostafa Farajpour, Mostafa Aalifar, Mohammad Sadat Hosseini
The effects of gamma irradiation (GR) on total phenol, anthocyanin and antioxidant activity were investigated in three different Persian pistachio nuts at doses of 0, 1, 2 and 4 kGy. The antioxidant activity, as determined by FRAP and DPPH methods, revealed a significant increase in the 1-2 kGy dose range. Total phenol content (TPC) revealed a similar pattern or increase in this range. However, when radiation was increased to 4 kGy, TPC in all genotypes decreased. A radiation dose of 1 kGy had no significant effect on anthocyanin content of Kale-Ghouchi (K) and Akbari (A) genotypes, while it significantly increased the anthocyanin content in the Ghazvini (G) genotype...
July 3, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28669431/radiology-online-patient-education-materials-provided-by-major-university-hospitals-do-they-conform-to-nih-and-ama-guidelines
#13
Arpan V Prabhu, Ashley L Donovan, Tudor Crihalmeanu, David R Hansberry, Nitin Agarwal, Sushil Beriwal, Hrishikesh Kale, Matthew Heller
AIMS: The internet creates opportunities for Americans to access medical information about imaging tests and modalities to guide them in their medical decision-making. Owing to health literacy variations in the general population, the American Medical Association and National Institutes of Health recommend patient education resources to be written between the third and seventh grade levels. Our purpose is to quantitatively assess the readability levels of online radiology educational materials, written for the public, in 20 major university hospitals...
May 22, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28668591/alteration-of-cortico-limbic-striatal-neural-system-in-major-depressive-disorder-and-bipolar-disorder
#14
Xiaowei Jiang, Xu Dai, Elliot Kale Edmiston, Qian Zhou, Ke Xu, Yifang Zhou, Feng Wu, Lingtao Kong, Shengnan Wei, Yuning Zhou, Miao Chang, Haiyang Geng, Dahai Wang, Ye Wang, Wenhui Cui, Fei Wang, Yanqing Tang
BACKGROUND: It is often difficult to differentiate major depressive disorder (MDD) and bipolar disorder (BD) merely according to clinical symptoms. Similarities and differences in neural activity between the two disorders remain unclear. In current study, we use amplitude of low-frequency fluctuations (ALFF) to compare neural activation changes between MDD and BD patients. METHODS: One hundred and eighty-three adolescents and young adults (57 MDD, 46 BD and 80 healthy controls, HC) were scanned during resting state...
October 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28662177/a-new-approach-for-the-assessment-of-the-toxicity-of-polyphenol-rich-compounds-with-the-use-of-high-content-screening-analysis
#15
Magdalena Boncler, Jacek Golanski, Magdalena Lukasiak, Malgorzata Redzynia, Jaroslaw Dastych, Cezary Watala
The toxicity of in vitro tested compounds is usually evaluated based on AC50 values calculated from dose-response curves. However, there is a large group of compounds for which a standard four-parametric sigmoid curve fitting may be inappropriate for estimating AC50. In the present study, 22 polyphenol-rich compounds were prioritized from the least to the most toxic based on the total area under and over the dose-response curves (AUOC) in relation to baselines. The studied compounds were ranked across three key cell indicators (mitochondrial membrane potential, cell membrane integrity and nuclear size) in a panel of five cell lines (HepG2, Caco-2, A549, HMEC-1, and 3T3), using a high-content screening (HCS) assay...
2017: PloS One
https://www.readbyqxmd.com/read/28658813/how-non-consumers-differ-from-consumers-a-qualitative-approach-to-synthesize-the-attributes-of-iron-folic-acid-end-users
#16
Surya Bali, Ankur Joshi, Sharad Tiwari, Daneshwar Singh, Viswanath Arutagi, Saket Kale, DInesh Kumar Pal
INTRODUCTION: Anaemia continues to be a major hurdle to achieve optimum health in Indian population context. Although government continues to promote Iron Folic Acid (IFA) supplementation as one of the key strategies to combat with burden of anaemia, the expected level of IFA consumption and subsequent anaemia reduction could not be achieved. This study tries to investigate those influences, concerns, experiences and behaviour from an end user perspective through a qualitative methodology which may affect the IFA consumption ambi-directionally...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28655958/spontaneous-arterial-catheter-fracture-and-embolisation-unpredicted-complication
#17
Suresh Babu Kale, Senthilkumar Ramalingam
Arterial cannulation is a common procedure in the care and management of critically ill patients. Blood pressure measurement, arterial blood sampling and cardiac output determinations are a few primary reasons for arterial cannulation. This invasive catheter placement also imposes certain risks and clinical management problems like bleeding, thrombosis and hematoma formation. Fracture and embolisation of arterial catheters placed in the femoral region is a rare and serious complication that may result in arterial occlusion and thrombosis...
June 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28655713/peers-without-fears-barriers-to-effective-communication-among-primary-care-physicians-and-oncologists-about-diagnostic-delays-in-cancer
#18
Allison Lipitz-Snyderman, Minal Kale, Laura Robbins, David Pfister, Elizabeth Fortier, Valerie Pocus, Susan Chimonas, Saul N Weingart
OBJECTIVE: Relatively little attention has been devoted to the role of communication between physicians as a mechanism for individual and organisational learning about diagnostic delays. This study's objective was to elicit physicians' perceptions about and experiences with communication among physicians regarding diagnostic delays in cancer. DESIGN, SETTING, PARTICIPANTS: Qualitative analysis based on seven focus groups. Fifty-one physicians affiliated with three New York-based academic medical centres participated, with six to nine subjects per group...
June 27, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28652082/medical-care-activities-among-spouses-of-older-adults-with-functional-disability-implications-for-caregiving-difficulties-and-gains
#19
Courtney A Polenick, Amanda N Leggett, Helen C Kales
OBJECTIVES: Spouses of older adults with functional disability often provide help with their partner's medical care. Yet little is known about the implications of these activities for spouses' caregiving experiences. We examined how spouses' medical care activities are linked to both positive and negative aspects of caregiving (difficulties and gains), and whether these associations vary by their age, gender, or education. DESIGN: Retrospective analysis of data from the 2011 National Health and Aging Trends Study and National Study of Caregiving cross-sectional studies...
May 4, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28646779/polychlorinated-biphenyls-in-the-surrounding-of-an-e-waste-recycling-facility-in-north-rhine-westphalia-levels-in-plants-and-dusts-spatial-distribution-homologue-pattern-and-source-identification-using-the-combination-of-plants-and-wind-direction-data
#20
Marcel Klees, Katja Hombrecher, Dieter Gladtke
During this study the occurrence of polychlorinated biphenyls (PCBs) in the surrounding of an e-waste recycling facility in North-Rhine Westphalia was analysed. PCB levels were analysed in curly kale, spruce needles, street dusts and dusts. Conspicuously high PCB concentrations in curly kale and spruce needles were found directly northwards of the industrial premises. Furthermore a concentration gradient originating from the industrial premises to the residential areas in direction southwest to northeast was evident...
June 21, 2017: Science of the Total Environment
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