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E Kale Edmiston
Transgender health research is experiencing growing pains. More transgender people have been able to access careers as health professionals or researchers in recent years. Transgender community advocates and professionals have pushed the field forward. The literature has shifted from a pathology model to a minority stress model of health disparity. This article is protected by copyright. All rights reserved.
May 17, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
O E Kale, O B Akinpelu, A A Bakare, F O Yusuf, R Gomba, D C Araka, T O Ogundare, A C Okolie, O Adebawo, O Odutola
BACKGROUND: This present study sought to assess the modulatory effects of five Nigerian traditional polyherbal in high fructose-fed, streptozotocin-induced (HF-STZ) Type 2 diabetes (T2D) in rats. T2D was achieved via fructose feeding (20%W/V ) ad libitum for 2 weeks and streptozotocin (STZ, 40 mg/kg) (15th Day) intraperitoneally. METHODS: Seventy-two hours after STZ injection, fourty-eight diabetic rats were divided into eight of 6 rats/group: Diabetic normal untreated, glibenclamide (GBLI, 0...
May 16, 2018: BMC Complementary and Alternative Medicine
Pauline Lorena Kale, Maria Helena Prado de Mello Jorge, Sandra Costa Fonseca, Angela Maria Cascão, Kátia Silveira da Silva, Ana Cristina Reis, Mauro Tomoyuki Taniguchi
The aim of this cross-sectional hospital-based study of 7,845 pregnancies was to analyze deaths of women hospitalized for childbirth and abortion, and fetal and neonatal deaths, in public hospitals in the cities of São Paulo, Rio de Janeiro and Niteroi (RJ), Brazil, in 2011. Outcomes of the pregnancies were: one maternal death, 498 abortions, 65 fetal deaths, 44 neonatal deaths and 7,291 infant survivors. Data were collected through interviews, medical records and the women's pregnancy records, and from the Mortality Information System (SIM)...
May 2018: Ciência & Saúde Coletiva
J M Kale Sniderman, Kia A Matley, Simon G Haberle, David J Cantrill
Pollen analysis is widely used to verify the geographic origin of honeys, but has never been employed in Australia. In this study, we analysed the pollen content of 173 unblended honey samples sourced from most of the commercial honey producing regions in southern Australia. Southern Australian vegetation is dominated by Eucalyptus (Myrtaceae) forests and, as expected, most Australian honeys are palynologically dominated by Eucalyptus, while other important components include Myrtaceae taxa such as Corymbia/Angophora and the tribe Leptospermeae; plus Brassicaceae, Echium, Macadamia, and Acacia...
2018: PloS One
Ravi Sharma, Manoj Phalak, Varidh Katiyar, Sachin Borkar, Shashank S Kale, Ashok K Mahapatra
Objective: The current opinion among neurosurgeons regarding the selection between microvascular decompression (MVD) and gamma knife radiosurgery for trigeminal neuralgia is not based on clear evidence. In this meta-analysis, we have attempted to synthesize the findings of the prospective trials comparing the efficacy and complications of the two procedures as primary treatment modality for medically refractory trigeminal neuralgia. Materials and Methods: The authors performed a systematic review of PubMed for manuscripts comparing the efficacy or complications of MVD and stereotactic radiosurgery for medically refractory trigeminal neuralgia...
May 2018: Neurology India
Yuanyuan Li, Phillip Buckhaults, Shizhao Li, Trygve O Tollefsbol
Breast cancer is the most common cancer and the second leading cause of cancer death among women. An important risk factor for breast cancer is individual genetic background which is initially generated early in human life; for example, during the processes of embryogenesis and fetal development in utero. Bioactive dietary components such as sulforaphane (SFN), an isothiocyanate from cruciferous vegetables including broccoli sprouts (BSp), cabbage and kale, has been shown to reduce the risk of developing many common cancers through regulation of epigenetic mechanisms...
May 15, 2018: Cancer Prevention Research
Neha Hasija, Suniti Kale, Kiran Kumar Girdhar
No abstract text is available yet for this article.
May 15, 2018: Korean Journal of Anesthesiology
Thanh Thanh L Nguyen, Lily C Chan, Kristin Borreginne, Rajas P Kale, Chunling Hu, Susannah J Tye
Patients with mood disorders are at increased risk for metabolic dysfunction. Co-occurrence of the two conditions is typically associated with a more severe disease course and poorer treatment outcomes. The specific pathophysiological mechanisms underlying this bidirectional relationship between mood and metabolic dysfunction remains poorly understood. However, it is likely that impairment of metabolic processes within the brain play a critical role. The insulin signaling pathway mediates metabolic homeostasis and is important in the regulation of neurotrophic and synaptic plasticity processes, including those involved in neurodegenerative diseases like Alzheimer's...
May 11, 2018: Neuroscience and Biobehavioral Reviews
Mohit Agrawal, Sachin A Borkar, Gaurav Khanna, Mehar C Sharma, Shashank S Kale
BACKGROUND: Gangliogliomas are rare intra-axial tumors. Cerebellar seizures caused by gangliogliomas have been rarely described. Pigmented neural cell tumors are well described in the literature but infrequent, especially when presenting as primary neuroepithelial tumors. Only five cases of pigmented ganglioglioma have been described in literature, out of which 4 were in the pediatric population. CASE DESCRIPTION: A seventeen year old female presented to us with cerebellar seizures, which resolved after tumor excision...
May 9, 2018: World Neurosurgery
Sabrina Copsel, Dietlinde Wolf, Brandon Kale, Henry Barreras, Casey O Lightbourn, Cameron S Bader, W Alperstein, Norman H Altman, Krishna V Komanduri, Robert B Levy
Regulatory T cells (Tregs) are essential for the maintenance of tolerance and immune homeostasis. In allogeneic hematopoietic stem cell transplantation (aHSCT), transfer of appropriate Treg numbers is a promising therapy for the prevention of graft-versus-host disease (GVHD). We have recently reported a novel approach which induces the marked expansion and selective activation of Tregs in vivo by targeting TNF receptor superfamily 25 (TNFRSF25) and CD25. A potential advance to promote clinical application of Treg cells to ameliorate GVHD and other disorders would be the generation of more potent Treg populations...
May 8, 2018: Biology of Blood and Marrow Transplantation
Helen C Kales, Laura N Gitlin, Barbara Stanislawski, H Myra Kim, Katherine Marx, Molly Turnwald, Claire Chiang, Constantine G Lyketsos
BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are universal and associated with multiple negative outcomes. This pilot randomized controlled trial (RCT) evaluated the effect of using the WeCareAdvisor, an innovative web-based tool developed to enable family caregivers to assess, manage, and track BPSD. METHODS: This RCT enrolled 57 dementia family caregivers from community and clinical settings in Ann Arbor, Michigan and Baltimore, Maryland...
May 10, 2018: BMC Geriatrics
Tejaswini S Kale, John D Tovar
Peptides provide a biomolecular scaffold for solubilizing and assembling π-conjugated molecules in aqueous media. The properties of such peptide-π chromophore conjugates can be manipulated by varying the constituent amino acid residues in the peptide backbone as well as the chromophore moieties. Such a precise handle on molecular structure leads to molecules with diverse macromolecular and material properties. We developed a versatile synthetic protocol that leads to a wide range of peptide-π chromophore conjugates in which the chromophores are covalently attached to the peptide backbone such that the chromophore is flanked by two peptide chains...
2018: Methods in Molecular Biology
Anuradha Vaidya, Vaijayanti Kale, Mariyah Poonawala, Suprita Ghode
AIM: To examine the stromal cell-mediated effects of trans-resveratrol (TRV) on the fate of hematopoietic stem cells (HSCs). Materials & methods: Proliferation assay, cell cycle analysis, apoptosis assay, flow cytometry, western blot. RESULTS: Using KG1a, we show that TRV has a dose-dependent effect on the proliferation of hematopoietic cells. Its stimulatory effect was significantly enhanced when the cells were cocultured with stromal cells. Addition of TRV in the coculture of murine bone marrow-derived HSCs and stromal cells led to a significant increase in the pool of long-term HSCs...
May 10, 2018: Regenerative Medicine
Sila Ulus, Cem Turam, Deniz Mutlu, Ipek Inal Kaleli, Mert Kocak, Umit Aksoy Ozcan
OBJECTIVES: Diagnosis of ventriculomegaly (VM) and identification of choroid plexus (CP) can be challenging with fetal magnetic resonance imaging (MRI). Our aim is to create an adjunct method for supporting the diagnosis of VM by investigating the CP-ventricular wall separation distance in fetuses with and without VM (nV) with fetal MRI. METHODS: T2-weighted fetal MRIs of 154 fetuses were retrospectively evaluated. The CP separation was defined as the distance between the medial wall of the dependent ventricle and distal tip of the CP glomus...
May 5, 2018: Brain & Development
Edzard Hangen, Stefan Gonser, Jutta Köhler
Polychlorinated dibenzo-p-dioxins and dibenzo-furans (PCDD/Fs) belong to the most toxic persistent organic environmental pollutants. Therefore, knowledge about their fate along the exposure path is of special concern. In order to comprehend the transfer of PCDD/Fs across different environmental compartments, PCDD/F concentrations in plants and in soil were evaluated. Pairs of soil and plant samples were selected according to the shortest distance between sampling points. At 15 sites PCDD/F concentrations in spruce needles and in forest humus layers where compared...
August 1, 2018: Science of the Total Environment
Sangram S Kale, Camille Villequey, Xu-Dong Kong, Alessandro Zorzi, Kaycie Deyle, Christian Heinis
Successful screening campaigns depend on large and structurally diverse collections of compounds. In macrocycle screening, variation of the molecular scaffold is important for structural diversity, but so far it has been challenging to diversify this aspect in large combinatorial libraries. Here, we report the cyclization of peptides with two chemical bridges to provide rapid access to thousands of different macrocyclic scaffolds in libraries that are easy to synthesize, screen and decode. Application of this strategy to phage-encoded libraries allowed for the screening of an unprecedented structural diversity of macrocycles against plasma kallikrein, which is important in the swelling disorder hereditary angioedema...
April 30, 2018: Nature Chemistry
André Vinícius Kaled Segato, Lucila Piasecki, Marcos Felipe Iparraguirre Nuñovero, Ulisses Xavier da Silva Neto, Vânia Portela Ditzel Westphalen, Gianluca Gambarini, Everdan Carneiro
INTRODUCTION: This study investigates the accuracy of 3D Endo software (Dentsply Sirona, Salzburg, Austria) to determine the working length when using preoperative cone-beam computed tomographic (CBCT) scans of extracted teeth, compared with conventional CBCT software and an electronic apex locator (EAL). METHODS: CBCT scans of 30 premolars were obtained. Using OnDemand3D software (Cybermed, Seoul, Korea), the measurement obtained from the coronal reference to the apical foramen (AF) was recorded as the conventional CBCT length...
April 24, 2018: Journal of Endodontics
Sheetal Kadam, Meghana Kanitkar, Kadambari Dixit, Rucha Deshpande, Vasudevan Seshadri, Vaijayanti Kale
Diabetes mellitus (DM) causes dysfunction of endothelial progenitor cells (EPCs), resulting in impaired wound healing. EPC therapy is a potential substitute to the current treatments of chronic wounds. Since EPCs isolated from diabetic patients are dysfunctional, and therefore pose an obstacle in their efficacious employment in autologous cell therapy, a strategy to rescue them prior to transplantation would be expected to improve the efficacy of autologous cell therapy multi-fold. With compromised ROS scavenging ability being the main cause of EPC Dysfunction (EPCD), ROS scavengers are likely to reverse or rescue EPC dysfunction...
April 27, 2018: Journal of Tissue Engineering and Regenerative Medicine
Ahmet Kale, Gulfem Basol, Taner Usta, Isa Cam
STUDY OBJECTIVE: To demonstrate the laparoscopic approach to malformed branches of the vessels entrapping the nerves of the sacral plexus. DESIGN: A step-by-step explanation of the surgery using video (instructive video). The Ethics Committee ruled that approval was not required for this video. SETTING: Derince Education and Research Hospital, Turkey PATIENT: : The 26-year-old patient who had failed the medical therapy, complained about numbness and burning pain on the right side of the vagina and pain radiating to the lower limb for approximately 36 months period...
April 24, 2018: Journal of Minimally Invasive Gynecology
Aydemir Kale
BACKGROUND There is no consensus on the efficacy of seizure prophylaxis in patients undergoing craniotomy. Some studies show that antiepileptic use decreases the risk of seizures, but other studies do not support this. The present study investigated the role of antiepileptic drugs in patient undergoing craniotomy due to various intracranial pathologies. MATERIAL AND METHODS A retrospective review was performed in adult patients undergoing craniotomy between January 2013 and June 2017. Results of 282 patients who did not have a history of seizures and had craniotomies for various reasons were included...
April 27, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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