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https://www.readbyqxmd.com/read/28057608/acupuncture-for-children-with-cerebral-palsy-a-systematic-review-protocol
#1
Taipin Guo, Bowen Zhu, Qian Zhang, Yejiao Yang, Qi He, Xinghe Zhang, Xiantao Tai
BACKGROUND: Cerebral palsy (CP), a childhood disease of high morbidity and serious harmfulness, has no effective therapies to completely relieve the associated pain. Acupuncture has been used widely in China to alleviate several CP symptoms, such as pain and motion disorders, despite the deficiency of high-quality evidence related to this practice. OBJECTIVE: The aim of this systematic review protocol is to assess the efficacy and safety of acupuncture for the treatment of children with CP...
January 5, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28044420/a-convenient-one-pot-route-to-screw-shaped-5-azahelicenes-via-rhodium-iii-catalyzed-multiple-c-h-bond-activation
#2
Lin Dong, Shuai-Shuai Li, Chen-Fei Liu, Guo-Tai Zhang, Ying-Qi Xia, Wei-Huan Li
A simple rhodium(III)-catalyzed cascade reaction of 7-azaindoles and alkynes through multiple C- bond activation has been achieved for the synthesis of unique [5]azahelicenes. The optical property of these screw-shaped helicene derivatives could be further utilized in electronic devices to recognize mercury ions.
January 2, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28024246/a-new-unsymmetrical-azine-derivative-based-on-coumarin-group-as-dual-modal-sensor-for-cn-and-fluorescent-off-on-for-zn-2
#3
Jing-Han Hu, You Sun, Jing Qi, Qiao Li, Tai-Bao Wei
A simple chemosensor YS based on coumarin group was designed and synthesized. Its structure was determined by single crystal X-ray diffraction analysis. In the presence of cyanide the sensor showed an immediate visible change in color from colorless to pale yellow by naked-eyes and produced a strong blue fluorescence rapidly in DMSO/H2O (3:7, v/v). The detection limit on fluorescence response of the sensor to CN(-) is down to 1.69×10(-7)M. In addition YS could show fluorescence turn-on response rapidly for Zn(2+) over other metals ions such as Fe(3+), Hg(2+), Ag(+), Ca(2+), Cu(2+), Co(2+), Ni(2+), Cd(2+), Pb(2+), Cr(3+) and Mg(2+) in aqueous solutions...
December 13, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28024245/phenazine-based-colorimetric-and-fluorescent-sensor-for-the-selective-detection-of-cyanides-based-on-supramolecular-self-assembly-in-aqueous-solution
#4
Hai-Li Zhang, Tai-Bao Wei, Wen-Ting Li, Wen-Juan Qu, Yan-Li Leng, Jian-Hui Zhang, Qi Lin, You-Ming Zhang, Hong Yao
Taking advantages of both the well-known phenazine structure and the mechanism of the supramolecular self-assembly and deprotonation process, the fluorescent and colorimetric sensor (ZL) was designed and synthesized, behaving as a circulation utilization (above 10 times) receptor for selective detection of cyanide anion (CN(-)) in aqueous media. Upon the addition of CN(-), the sensor displayed obvious color changes from yellow to jacinth by naked eyes and the fluorescence immediately quenched (<10s). With respect to other common anions, the sensor possessed high selectivity and sensitivity (0...
December 15, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28011712/genome-wide-association-study-of-parkinson-s-disease-in-east-asians
#5
Jia Nee Foo, Louis C Tan, Ishak D Irwan, Wing-Lok Au, Hui Qi Low, Kumar-M Prakash, Azlina Ahmad-Annuar, Jinxin Bei, Anne Yy Chan, Chiung Mei Chen, Yi-Chun Chen, Sun Ju Chung, Hao Deng, Shen-Yang Lim, Vincent Mok, Hao Pang, Zhong Pei, Rong Peng, Hui-Fang Shang, Kyuyoung Song, Ai Huey Tan, Yih-Ru Wu, Tin Aung, Ching-Yu Cheng, Fook Tim Chew, Soo-Hong Chew, Siow-Ann Chong, Richard P Ebstein, Jimmy Lee, Seang-Mei Saw, Adeline Seow, Mythily Subramaniam, E-Shyong Tai, Eranga N Vithana, Tien-Yin Wong, Khai Koon Heng, Wee-Yang Meah, Chiea Chuen Khor, Hong Liu, Furen Zhang, Jianjun Liu, Eng-King Tan
Genome-wide association studies (GWAS) on Parkinson's disease (PD) have mostly been done in Europeans and Japanese. No study has been done in Han Chinese, which make up nearly a fifth of the world population. We conducted the first Han Chinese GWAS analyzing a total of 22,729 subjects (5,125 PD cases and 17,604 controls) from Singapore, Hong Kong, Malaysia, Korea, mainland China and Taiwan. We performed imputation, merging and logistic regression analyses of 2,402,394 SNPs passing quality control filters, adjusted for the first three principal components...
December 22, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27811669/a-new-species-of-the-genus-bothrioplana-platyhelminthes-bothrioplanida-bothrioplanidae-and-a-new-species-of-the-genus-pentacoelum-tricladida-bdellouridae-from-southern-china
#6
Yi He, Jia-Qi Zhao, Wan-Ru Ning, Jie-Yi Zhuang, Yu Zhang, An-Tai Wang
Two new species of turbellarians, Bothrioplana sinensis n. sp., and Pentacoelum sinensis n. sp., were described based on their reproductive behavior, ontogenic development, morphology in whole-mounted and sectioned specimens, and 18S rDNA phylogenetic classification. Bothrioplana sinensis n. sp. represents a newly recorded order in China and the second identified species in the genus Bothrioplana. It is characterized by a pair of spherical-shaped well-developed testes located dorsally behind the pharynx, and the common vas deference located ventrally to the gonopore...
October 31, 2016: Zootaxa
https://www.readbyqxmd.com/read/27799547/discovery-of-selective-small-molecule-hdac6-inhibitor-for-overcoming-proteasome-inhibitor-resistance-in-multiple-myeloma
#7
Teru Hideshima, Jun Qi, Ronald M Paranal, Weiping Tang, Edward Greenberg, Nathan West, Meaghan E Colling, Guillermina Estiu, Ralph Mazitschek, Jennifer A Perry, Hiroto Ohguchi, Francesca Cottini, Naoya Mimura, Güllü Görgün, Yu-Tzu Tai, Paul G Richardson, Ruben D Carrasco, Olaf Wiest, Stuart L Schreiber, Kenneth C Anderson, James E Bradner
Multiple myeloma (MM) has proven clinically susceptible to modulation of pathways of protein homeostasis. Blockade of proteasomal degradation of polyubiquitinated misfolded proteins by the proteasome inhibitor bortezomib (BTZ) achieves responses and prolongs survival in MM, but long-term treatment with BTZ leads to drug-resistant relapse in most patients. In a proof-of-concept study, we previously demonstrated that blocking aggresomal breakdown of polyubiquitinated misfolded proteins with the histone deacetylase 6 (HDAC6) inhibitor tubacin enhances BTZ-induced cytotoxicity in MM cells in vitro...
November 15, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27757943/enhanced-emission-of-quantum-system-in-si-ge-nanolayer-structure
#8
Zhong-Mei Huang, Wei-Qi Huang, Tai-Ge Dong, Gang Wang, Xue-Ke Wu
It is very interesting that the enhanced peaks near 1150 and 1550 nm are observed in the photoluminescence (PL) spectra in the quantum system of Si-Ge nanolayer structure, which have the emission characteristics of a three-level system with quantum dots (QDs) pumping and emission of quasi-direct-gap band, in our experiment. In the preparing process of Si-Ge nanolayer structure by using a pulsed laser deposition method, it is discovered that the nanocrystals of Si and Ge grow in the (100) and (111) directions after annealing or electron beam irradiation...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27670763/trem1-facilitates-microglial-phagocytosis-of-amyloid-beta
#9
Teng Jiang, Ying-Dong Zhang, Qing Gao, Jun-Shan Zhou, Xi-Chen Zhu, Huan Lu, Jian-Quan Shi, Lan Tan, Qi Chen, Jin-Tai Yu
As the most common type of neurodegenerative disease, Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β peptide (Aβ) within the brain. Triggering receptor expressed on myeloid cells (TREM) 1 is an immune receptor expressed by mononuclear phagocytes including monocytes and microglia, coupling with TYRO protein tyrosine kinase binding protein to regulate immune reactions. Emerging evidence indicates that rs6910730(G), an intronic variant of TREM1, is associated with an increased Aβ neuropathology in the brains of elderly subjects, but the underlying mechanisms remain unclear...
November 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27646279/mind-body-interventions-for-irritable-bowel-syndrome-patients-in-the-chinese-population-a-systematic-review-and-meta-analysis
#10
Weidong Wang, Fang Wang, Feng Fan, Ana Cristina Sedas, Jian Wang
PURPOSE: The aim of this study is to identify and assess evidence related to the efficacy of mind-body interventions on irritable bowel syndrome (IBS) in the Chinese population. METHOD: Drawn from Chinese databases, nine RCTs and three Q-E studies were included in the systematic review. The methodological quality of RCTs was evaluated based on the following criteria: adequate sequence generation, allocation concealment, blinding, completeness of outcome data, selective reporting, and other potential biases...
September 19, 2016: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/27643737/removal-of-cephalosporin-antibiotics-7-aca-from-wastewater-during-the-cultivation-of-lipid-accumulating-microalgae
#11
Wan-Qian Guo, He-Shan Zheng, Shuo Li, Juan-Shan Du, Xiao-Chi Feng, Ren-Li Yin, Qing-Lian Wu, Nan-Qi Ren, Jo-Shu Chang
The aim of this study is to evaluate the feasibility of using lipid-accumulating microalgae to remove cephalosporin antibiotics 7-amino cephalosporanic acid (7-ACA) from wastewater with the additional benefit of biofuels production. Three isolated microalgal strains (namely, Chlorella sp. Cha-01, Chlamydomonas sp. Tai-03 and Mychonastes sp. YL-02) were cultivated under 7-ACA stress and their biomass productivity, lipid production and N-NO3(-) consumption were monitored. It was found that 7-ACA had slight inhibition effects on the microalgal growth at the ratio of 12...
December 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27596441/na2co3-responsive-mechanisms-in-halophyte-puccinellia-tenuiflora-roots-revealed-by-physiological-and-proteomic-analyses
#12
Qi Zhao, Jinwei Suo, Sixue Chen, Yudan Jin, Xiaolin Ma, Zepeng Yin, Yuhong Zhang, Tai Wang, Ji Luo, Wenhai Jin, Xia Zhang, Zhiqiang Zhou, Shaojun Dai
Soil alkalization severely affects crop growth and agricultural productivity. Alkali salts impose ionic, osmotic, and high pH stresses on plants. The alkali tolerance molecular mechanism in roots from halophyte Puccinellia tenuiflora is still unclear. Here, the changes associated with Na2CO3 tolerance in P. tenuiflora roots were assessed using physiological and iTRAQ-based quantitative proteomic analyses. We set up the first protein dataset in P. tenuiflora roots containing 2,671 non-redundant proteins. Our results showed that Na2CO3 slightly inhibited root growth, caused ROS accumulation, cell membrane damage, and ion imbalance, as well as reduction of transport and protein synthesis/turnover...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27590703/validation-of-a-new-simple-scale-to-measure-symptoms-in-heart-failure-from-traditional-chinese-medicine-view-a-cross-sectional-questionnaire-study
#13
Tieh-Cheng Fu, Yi-Chung Lin, Ching-Mao Chang, Wei-Ling Chou, Pei-Hsun Yuan, Min-Hui Liu, Chao-Hung Wang, Juei-Chao Chen, Hen-Hong Chang, Tai-Long Pan
BACKGROUND: Current clinical practices used to functionally classify heart failure (HF) are time-consuming, expensive, or require complex calculations. This study aimed to design an inquiry list from the perspective of traditional Chinese medicine (TCM) that could be used in routine clinical practice to resolve these problems. METHODS: The severity of documented HF in 115 patients was classified according to their performance in maximal exercise tests into New York Heart Association (NYHA) functional classification (FC) II or NYHA FC III...
September 2, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27584836/effect-of-community-based-social-skills-training-and-tai-chi-exercise-on-outcomes-in-patients-with-chronic-schizophrenia-a-randomized-one-year-study
#14
RANDOMIZED CONTROLLED TRIAL
Ruiying Kang, Yeqing Wu, Zhiwu Li, Jun Jiang, Qi Gao, Yuncui Yu, Keming Gao, Yuxiang Yan, Yan He
BACKGROUND: Antipsychotic drugs are limited in their ability to improve negative symptoms, quality of life, and medication adherence in patients with schizophrenia. The addition of nonpharmacological interventions like social skills training has a positive effect on medication adherence and decreases rehospitalization rates but is limited in improving patients' symptoms, aggressive behaviors, and quality of life. Aerobic exercise, especially Tai-chi, can potentially reduce psychopathological and negative symptoms, decrease aggressive behaviors, and improve quality of life...
2016: Psychopathology
https://www.readbyqxmd.com/read/27583423/complementary-integrative-therapies-that-work-a-review-of-the-evidence
#15
Benjamin Kligler, Raymond Teets, Melissa Quick
Significant evidence supports the effectiveness and safety of several complementary or integrative treatment approaches to common primary care problems. Acupuncture is effective in the management of chronic low back pain. Mind-body interventions such as cognitive behavior therapy, yoga, tai chi, qi gong, and music therapy may be helpful for treating insomnia. Exercise can reduce anxiety symptoms. Herbal preparations and nutritional supplements can be useful as first-line therapy for certain conditions, such as fish oil for hypertriglyceridemia, St...
September 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27548839/qigong-tai-chi-for-sleep-and-fatigue-in-prostate-cancer-patients-undergoing-radiotherapy-a-randomized-controlled-trial
#16
Jennifer McQuade, Sarah Prinsloo, David Z Chang, Amy Spelman, Qi Wei, Karen Basen-Engquist, Carol Harrison, Zonghao Zhang, Debra Kuban, Andrew Lee, Lorenzo Cohen
OBJECTIVES: Sleep disturbances and fatigue are common in prostate cancer patients undergoing radiotherapy. Prior research suggests mind-body techniques may improve these outcomes. We conducted a randomized-controlled trial of qigong/tai chi (QGTC) in men with prostate cancer undergoing radiotherapy. METHODS: Men with prostate cancer starting definitive radiation were randomized to one of three groups: (1) QGTC; (2) light exercise (LE); or (3) wait list control (WLC)...
August 22, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27548520/vascular-stiffness-mechanoactivates-yap-taz-dependent-glutaminolysis-to-drive-pulmonary-hypertension
#17
Thomas Bertero, William M Oldham, Katherine A Cottrill, Sabrina Pisano, Rebecca R Vanderpool, Qiujun Yu, Jingsi Zhao, Yiyin Tai, Ying Tang, Ying-Yi Zhang, Sofiya Rehman, Masataka Sugahara, Zhi Qi, John Gorcsan, Sara O Vargas, Rajan Saggar, Rajeev Saggar, W Dean Wallace, David J Ross, Kathleen J Haley, Aaron B Waxman, Victoria N Parikh, Teresa De Marco, Priscilla Y Hsue, Alison Morris, Marc A Simon, Karen A Norris, Cedric Gaggioli, Joseph Loscalzo, Joshua Fessel, Stephen Y Chan
Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary hypertension (PH). However, the mechanisms by which biophysical properties of the vascular extracellular matrix (ECM) relate to metabolic processes important in PH remain undefined. In this work, we examined cultured pulmonary vascular cells and various types of PH-diseased lung tissue and determined that ECM stiffening resulted in mechanoactivation of the transcriptional coactivators YAP and TAZ (WWTR1). YAP/TAZ activation modulated metabolic enzymes, including glutaminase (GLS1), to coordinate glutaminolysis and glycolysis...
September 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27512955/ginsenoside-compound-k-sensitizes-human-colon-cancer-cells-to-trail-induced-apoptosis-via-autophagy-dependent-and-independent-dr5-upregulation
#18
Lei Chen, Yue Meng, Qi Sun, Zhongyu Zhang, Xiaoqing Guo, Xiaotong Sheng, Guihua Tai, Hairong Cheng, Yifa Zhou
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a potent cancer cell-specific apoptosis-inducing cytokine with little toxicity to most normal cells. However, acquired resistance of cancer cells to TRAIL is a roadblock. Agents that can either potentiate the effect of TRAIL or overcome resistance to TRAIL are urgently needed. This article reports that ginsenoside compound K (CK) potentiates TRAIL-induced apoptosis in HCT116 colon cancer cells and sensitizes TRAIL-resistant colon cancer HT-29 cells to TRAIL...
August 11, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27492814/one-pot-construction-of-fused-polycyclic-heteroarenes-involving-7-azaindoles-and-%C3%AE-%C3%AE-unsaturated-ketones
#19
Shuai-Shuai Li, Wei-Huan Li, Guo-Tai Zhang, Ying-Qi Xia, Chen-Fei Liu, Fu Su, Xiao-Mei Zhang, Lin Dong
A novel one-pot synthesis of π-conjugated polycyclic compounds, which could undergo further facile transformation to form complex polycyclic heteroarene compounds, has been realized between 7-azaindoles and α,β-unsaturated ketones. This distinctive cascade process proceeds via a rhodium(iii)-catalyzed alkylation/copper-catalyzed radical annulation-aromatization pathway.
August 16, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27398621/the-genetic-architecture-of-type-2-diabetes
#20
Christian Fuchsberger, Jason Flannick, Tanya M Teslovich, Anubha Mahajan, Vineeta Agarwala, Kyle J Gaulton, Clement Ma, Pierre Fontanillas, Loukas Moutsianas, Davis J McCarthy, Manuel A Rivas, John R B Perry, Xueling Sim, Thomas W Blackwell, Neil R Robertson, N William Rayner, Pablo Cingolani, Adam E Locke, Juan Fernandez Tajes, Heather M Highland, Josee Dupuis, Peter S Chines, Cecilia M Lindgren, Christopher Hartl, Anne U Jackson, Han Chen, Jeroen R Huyghe, Martijn van de Bunt, Richard D Pearson, Ashish Kumar, Martina Müller-Nurasyid, Niels Grarup, Heather M Stringham, Eric R Gamazon, Jaehoon Lee, Yuhui Chen, Robert A Scott, Jennifer E Below, Peng Chen, Jinyan Huang, Min Jin Go, Michael L Stitzel, Dorota Pasko, Stephen C J Parker, Tibor V Varga, Todd Green, Nicola L Beer, Aaron G Day-Williams, Teresa Ferreira, Tasha Fingerlin, Momoko Horikoshi, Cheng Hu, Iksoo Huh, Mohammad Kamran Ikram, Bong-Jo Kim, Yongkang Kim, Young Jin Kim, Min-Seok Kwon, Juyoung Lee, Selyeong Lee, Keng-Han Lin, Taylor J Maxwell, Yoshihiko Nagai, Xu Wang, Ryan P Welch, Joon Yoon, Weihua Zhang, Nir Barzilai, Benjamin F Voight, Bok-Ghee Han, Christopher P Jenkinson, Teemu Kuulasmaa, Johanna Kuusisto, Alisa Manning, Maggie C Y Ng, Nicholette D Palmer, Beverley Balkau, Alena Stancáková, Hanna E Abboud, Heiner Boeing, Vilmantas Giedraitis, Dorairaj Prabhakaran, Omri Gottesman, James Scott, Jason Carey, Phoenix Kwan, George Grant, Joshua D Smith, Benjamin M Neale, Shaun Purcell, Adam S Butterworth, Joanna M M Howson, Heung Man Lee, Yingchang Lu, Soo-Heon Kwak, Wei Zhao, John Danesh, Vincent K L Lam, Kyong Soo Park, Danish Saleheen, Wing Yee So, Claudia H T Tam, Uzma Afzal, David Aguilar, Rector Arya, Tin Aung, Edmund Chan, Carmen Navarro, Ching-Yu Cheng, Domenico Palli, Adolfo Correa, Joanne E Curran, Denis Rybin, Vidya S Farook, Sharon P Fowler, Barry I Freedman, Michael Griswold, Daniel Esten Hale, Pamela J Hicks, Chiea-Chuen Khor, Satish Kumar, Benjamin Lehne, Dorothée Thuillier, Wei Yen Lim, Jianjun Liu, Yvonne T van der Schouw, Marie Loh, Solomon K Musani, Sobha Puppala, William R Scott, Loïc Yengo, Sian-Tsung Tan, Herman A Taylor, Farook Thameem, Gregory Wilson, Tien Yin Wong, Pål Rasmus Njølstad, Jonathan C Levy, Massimo Mangino, Lori L Bonnycastle, Thomas Schwarzmayr, João Fadista, Gabriela L Surdulescu, Christian Herder, Christopher J Groves, Thomas Wieland, Jette Bork-Jensen, Ivan Brandslund, Cramer Christensen, Heikki A Koistinen, Alex S F Doney, Leena Kinnunen, Tõnu Esko, Andrew J Farmer, Liisa Hakaste, Dylan Hodgkiss, Jasmina Kravic, Valeriya Lyssenko, Mette Hollensted, Marit E Jørgensen, Torben Jørgensen, Claes Ladenvall, Johanne Marie Justesen, Annemari Käräjämäki, Jennifer Kriebel, Wolfgang Rathmann, Lars Lannfelt, Torsten Lauritzen, Narisu Narisu, Allan Linneberg, Olle Melander, Lili Milani, Matt Neville, Marju Orho-Melander, Lu Qi, Qibin Qi, Michael Roden, Olov Rolandsson, Amy Swift, Anders H Rosengren, Kathleen Stirrups, Andrew R Wood, Evelin Mihailov, Christine Blancher, Mauricio O Carneiro, Jared Maguire, Ryan Poplin, Khalid Shakir, Timothy Fennell, Mark DePristo, Martin Hrabé de Angelis, Panos Deloukas, Anette P Gjesing, Goo Jun, Peter Nilsson, Jacquelyn Murphy, Robert Onofrio, Barbara Thorand, Torben Hansen, Christa Meisinger, Frank B Hu, Bo Isomaa, Fredrik Karpe, Liming Liang, Annette Peters, Cornelia Huth, Stephen P O'Rahilly, Colin N A Palmer, Oluf Pedersen, Rainer Rauramaa, Jaakko Tuomilehto, Veikko Salomaa, Richard M Watanabe, Ann-Christine Syvänen, Richard N Bergman, Dwaipayan Bharadwaj, Erwin P Bottinger, Yoon Shin Cho, Giriraj R Chandak, Juliana C N Chan, Kee Seng Chia, Mark J Daly, Shah B Ebrahim, Claudia Langenberg, Paul Elliott, Kathleen A Jablonski, Donna M Lehman, Weiping Jia, Ronald C W Ma, Toni I Pollin, Manjinder Sandhu, Nikhil Tandon, Philippe Froguel, Inês Barroso, Yik Ying Teo, Eleftheria Zeggini, Ruth J F Loos, Kerrin S Small, Janina S Ried, Ralph A DeFronzo, Harald Grallert, Benjamin Glaser, Andres Metspalu, Nicholas J Wareham, Mark Walker, Eric Banks, Christian Gieger, Erik Ingelsson, Hae Kyung Im, Thomas Illig, Paul W Franks, Gemma Buck, Joseph Trakalo, David Buck, Inga Prokopenko, Reedik Mägi, Lars Lind, Yossi Farjoun, Katharine R Owen, Anna L Gloyn, Konstantin Strauch, Tiinamaija Tuomi, Jaspal Singh Kooner, Jong-Young Lee, Taesung Park, Peter Donnelly, Andrew D Morris, Andrew T Hattersley, Donald W Bowden, Francis S Collins, Gil Atzmon, John C Chambers, Timothy D Spector, Markku Laakso, Tim M Strom, Graeme I Bell, John Blangero, Ravindranath Duggirala, E Shyong Tai, Gilean McVean, Craig L Hanis, James G Wilson, Mark Seielstad, Timothy M Frayling, James B Meigs, Nancy J Cox, Rob Sladek, Eric S Lander, Stacey Gabriel, Noël P Burtt, Karen L Mohlke, Thomas Meitinger, Leif Groop, Goncalo Abecasis, Jose C Florez, Laura J Scott, Andrew P Morris, Hyun Min Kang, Michael Boehnke, David Altshuler, Mark I McCarthy
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing in 12,940 individuals from five ancestry groups...
August 4, 2016: Nature
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