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https://www.readbyqxmd.com/read/29276973/molecular-and-functional-characterization-of-tumor-induced-factor-tif-hamster-homolog-of-cxcl3-gro%C3%AE-displays-tumor-suppressive-activity
#1
Lili Jin, Zhou-Fang Li, Da-Kui Wang, Meina Sun, Wei Qi, Qiang Ma, Li Zhang, Chun Chu, Elaine Y M Chan, Susanna S T Lee, Helen Wise, Ka-Fai To, Ying Shi, Naiming Zhou, Wing-Tai Cheung
Previously our lab has created a mouse ovarian xenograft model of copy number variation (CNV)-mediated G protein-coupled receptor (GPCR) MAS-driven tumorigenesis, and RNA profiling identified a putative chemokine tumor-induced factor (Tif). Sequence analysis and chemotactic study suggested that Tif was likely to be a hamster homolog of human GROγ (CXCL3) [IJC 125 (2009): 1316-1327]. In the present study, we report the molecular and functional characterization of the Tif gene. Genomic study of CHO-K1 cells indicated that Tif gene consisted of 4 exons, characterized with an antisense B1 element which is embedded in the fourth exon...
December 22, 2017: Cytokine
https://www.readbyqxmd.com/read/29247953/efficient-decolorization-of-typical-azo-dyes-using-low-frequency-ultrasound-in-presence-of-carbonate-and-hydrogen-peroxide
#2
Tongqian Zhao, Peng Li, Chao Tai, Jiaping She, Yongguang Yin, Yong'an Qi, Guocheng Zhang
The aims of this study as to evaluate and understand the decolorization of azo dyes using carbonate and hydrogen peroxide under low-frequency ultrasonic irradiation. Under optimal conditions, the decolorization ratio of acid orange 8 (AO 8), a typical azo dye, was > 90% after 2 h of irradiation. The decolorization rate of AO 8 was 0.023 min-1 under ultrasonic irradiation, which was about two times that without ultrasound. Different from the results of other published studies, OH played a minor role, while CO3- played the most important role in AO 8 ultrasonic decolorization in the presence of CO32- and H2O2, with a contribution of 56...
December 7, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29247448/itraq-based-quantitative-proteomics-reveals-the-new-evidence-base-for-traumatic-brain-injury-treated-with-targeted-temperature-management
#3
Shi-Xiang Cheng, Zhong-Wei Xu, Tai-Long Yi, Hong-Tao Sun, Cheng Yang, Ze-Qi Yu, Xiao-Sa Yang, Xiao-Han Jin, Yue Tu, Sai Zhang
This study aimed to investigate the effects of targeted temperature management (TTM) modulation on traumatic brain injury (TBI) and the involved mechanisms using quantitative proteomics technology. SH-SY5Y and HT-22 cells were subjected to moderate stretch injury using the cell injury controller (CIC), followed by incubation at TTM (mild hypothermia, 32°C), or normothermia (37°C). The real-time morphological changes, cell cycle phase distribution, death, and cell viability were evaluated. Moderate TBI was produced by the controlled cortical impactor (CCI), and the effects of TTM on the neurological damage, neurodegeneration, cerebrovascular histopathology, and behavioral outcome were determined in vivo...
December 15, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29240733/use-of-tai-fish-to-visualize-neural-ensembles-activated-by-multiple-stimuli
#4
Qi Zhang, Qiye He, Jihua Wang, Chaoying Fu, Hailan Hu
Researchers in behavioral neuroscience have long sought imaging techniques that can identify and distinguish neural ensembles that are activated by sequentially applied stimuli at single-cell resolution across the whole brain. Taking advantage of the different kinetics of immediate-early genes' mRNA and protein expression, we addressed this problem by developing tyramide-amplified immunohistochemistry-fluorescence in situ hybridization (TAI-FISH), a dual-epoch neural-activity-dependent labeling protocol. Here we describe the step-by-step procedures for TAI-FISH on brain sections from mice that were sequentially stimulated by morphine (appetitive first stimulus) and foot shock (aversive second stimulus)...
January 2018: Nature Protocols
https://www.readbyqxmd.com/read/29208249/aortic-aneurysm-in-takayasu-arteritis
#5
Kun-Qi Yang, Xu Meng, Ying Zhang, Peng Fan, Lin-Ping Wang, Hui-Min Zhang, Hai-Ying Wu, Xiong-Jing Jiang, Jun Cai, Xian-Liang Zhou, Ru-Tai Hui, De-Yu Zheng, Li-Sheng Liu
BACKGROUND: Aortic aneurysm (AA) is a severe complication of Takayasu arteritis (TA). This study aimed to evaluate the prevalence, clinical and imaging features, management and long-term outcomes of AA in patients with TA. MATERIALS AND METHODS: A retrospective study was performed of TA patients with AA admitted to Fuwai Hospital from 1996-2015. Baseline clinical data and follow-up data of TA patients with AA were collected and analyzed. RESULTS: Thirty-nine (4...
December 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29205237/pillararene-based-fluorescent-chemosensors-recent-advances-and-perspectives
#6
Jin-Fa Chen, Qi Lin, You-Ming Zhang, Hong Yao, Tai-Bao Wei
In 2008, a new class of pillar-shaped supramolecular macrocyclic hosts was reported, known as "pillararenes". Their particular electron-rich cavity and the ease of their functionalization offer possibilities for the design and synthesis of novel fluorescent chemosensors. Subsequently, pillararene-based fluorescent sensors and probes have been rapidly developed. This feature article covers the most recent contributions from the pillararene-based fluorescent sensor field in terms of anion/cation sensing, small molecule recognition, biomolecule detection, fluorescent supramolecular aggregates, and biomedical imaging...
December 5, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29168515/coordination-mode-induced-isomeric-cyclometalated-ir-tpy-nbi-cl-pf6-complexes-distinct-luminescence-self-assembly-and-cellular-imaging-behaviors
#7
Tai-Bao Gao, Run-Qi Yan, Alexander J Metherell, Deng-Ke Cao, De-Ju Ye, Michael D Ward
Two isomeric Ir(iii) complexes Ir-O and Ir-R arising from the different coordination mode of a naphthalene-containing ligand, show distinct luminescence, self-assembly ability and cellular imaging behaviors.
November 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29165843/pillar-5-arenes-based-supramolecular-organic-framework-with-multi-guests-detection-and-recyclable-separation-properties
#8
Qi Lin, Yan-Qing Fan, Peng-Peng Mao, Lu Liu, Juan Liu, You-Ming Zhang, Hong Yao, Tai-Bao Wei
The selective detection and separation of target ions or molecules is an intriguing issue. Herein, a novel supramolecular organic framework (SOF-THBP) was constructed by bis-thioacetylhydrazine functionalized pillar[5]arenes. The SOF-THBP shows fluorescent response for Fe3+, Cr3+, Hg2+ and Cu2+. The xerogel of SOF-THBP shows excellent recyclable separation properties for these metal ions and the absorption rates were up to 99.29%. More interestingly, by rationally introduced these metal ions into the SOF-THBP, a series of metal ions coordinated SOFs (MSOFs) such as MSOF-Fe, MSOF-Hg and MSOF-Cu were constructed...
November 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29158558/protein-arginine-methyltransferase-5-prmt5-has-prognostic-relevance-and-is-a-druggable-target-in-multiple-myeloma
#9
A Gullà, T Hideshima, G Bianchi, M Fulciniti, M K Samur, J Qi, Y-T Tai, T Harada, E Morelli, N Amodio, R Carrasco, P Tagliaferri, N C Munshi, P Tassone, K C Anderson
Arginine methyltransferases critically regulate cellular homeostasis by modulating the functional outcome of their substrates. The protein arginine methyltransferase 5 (PRMT5) is an enzyme involved in growth and survival pathways promoting tumorigenesis. However, little is known about the biologic function of PRMT5 and its therapeutic potential in multiple myeloma (MM). In the present study, we identified and validated PRMT5 as a new therapeutic target in MM. PRMT5 is overexpressed in patient MM cells and associated with decreased PFS and OS...
November 21, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29136927/enantioselective-determination-of-metconazole-in-multi-matrices-by-high-performance-liquid-chromatography
#10
Rujian He, Jun Fan, Qi Tan, Yecai Lai, Xiaodong Chen, Tai Wang, Ying Jiang, Yaomou Zhang, Weiguang Zhang
A reliable and effective HPLC analytical method has been developed to stereoselectively quantify metconazole in soil and flour matrices. Effects of polysaccharide chiral stationary phase, type and content of alcoholic modifier on separation of racemic metconazole have been discussed in detail. Resolution and quantitative determination of metconazole stereoisomers were performed by using an Enantiopak OD column, with the n-hexane-ethanol mixture (97:3, v/v) at the flow rate of 1.0mL/min. Then, extraction and cleanup procedures followed by the modified QuEChERS (quick, easy, cheap, effective, rugged and safe) method were used for metconazole racemate in soil and flour matrices...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29103411/prospects-of-a-comprehensive-evaluation-system-for-traditional-chinese-medicine-services
#11
REVIEW
Wen-Jie Xu, Ling-Tai Wang, Zhi-Ping Zhao, Li-Ming Zhu, Liang-Hua Zu, Qi Zhang, Dan-Bo Dou
Traditional Chinese medicine (TCM) is a unique health resource in China and one of the main representative traditional medicines globally. TCM has formed a new way of looking at medical practices, health care, scientific research, education, industry and culture. It focuses on promoting and safeguarding the health of people, with an increasing contribution to economic and social development. Establishing a comprehensive evaluation system in accordance with the characteristics of TCM services could promote the scientific merit and the standardization of services management...
November 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28985428/an-rna-editing-dsrna-binding-independent-gene-regulatory-mechanism-of-adars-and-its-clinical-implication-in-cancer
#12
Lihua Qi, Yangyang Song, Tim Hon Man Chan, Henry Yang, Chi Ho Lin, Daryl Jin Tai Tay, HuiQi Hong, Sze Jing Tang, Kar Tong Tan, Xi Xiao Huang, Jaymie Siqi Lin, Vanessa Hui En Ng, Julien Jean Pierre Maury, Daniel G Tenen, Leilei Chen
Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by Adenosine DeAminases acting on double-stranded RNA(dsRNA) (ADAR), occurs predominantly in the 3' untranslated regions (3'UTRs) of spliced mRNA. Here we uncover an unanticipated link between ADARs (ADAR1 and ADAR2) and the expression of target genes undergoing extensive 3'UTR editing. Using METTL7A (Methyltransferase Like 7A), a novel tumor suppressor gene with multiple editing sites at its 3'UTR, we demonstrate that its expression could be repressed by ADARs beyond their RNA editing and double-stranded RNA (dsRNA) binding functions...
October 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28933493/novel-multi-analyte-responsive-ionic-supramolecular-gels-based-on-pyridinium-functionalized-naphthalimide
#13
Qi Lin, Peng-Peng Mao, Yan-Qing Fan, Pei-Pei Jia, Juan Liu, You-Ming Zhang, Hong Yao, Tai-Bao Wei
A novel ionic supramolecular gel (is-G) is synthesized using N-(pyridinium-4-yl)-naphthalimide (G1) and n-pentanoic acid. By rationally introducing competitive coordination into is-G, two ion coordinated ionic supramolecular gels is-IG and is-FeG (coordinated with I(-) and Fe(3+), respectively) are obtained. is-IG could fluorescently "turn-on" detect Hg(2+) and l-Arg with specific selectivity, whereas, is-FeG could accurately identify l-Ser via fluorescence in water. Moreover, ion or amino acid responsive films based on these ionic supramolecular gels are prepared...
October 18, 2017: Soft Matter
https://www.readbyqxmd.com/read/28932857/a-novel-supramolecular-organogel-based-on-acylhydrazone-functionalized-pillar-5-arene-acts-as-an-i-responsive-smart-material
#14
Qi Lin, Xiao-Mei Jiang, Lu Liu, Jin-Fa Chen, You-Ming Zhang, Hong Yao, Tai-Bao Wei
A novel organic gelator (PZ) has been synthesized by rationally connecting a pillar[5]arene moiety and a bis(hexadecyloxy)phenyl functionalized acylhydrazone moiety. PZ could self-assemble into a supramolecular polymer and form a stable organogel (OPZ) in cyclohexanol by multi-self-assembly driving forces such as C-Hπ, ππ, vdW and hydrogen bonding interactions. The organogel (OPZ) shows blue aggregation-induced emission (AIE). Interestingly, the organogel OPZ could sense iodide ions (I(-)) in the gel-gel state with high selectivity and sensitivity...
October 11, 2017: Soft Matter
https://www.readbyqxmd.com/read/28915274/prevalence-of-mind-and-body-exercises-mbe-in-relation-to-demographics-self-rated-health-and-purchases-of-prescribed-psychotropic-drugs-and-analgesics
#15
MULTICENTER STUDY
Lina Rådmark, Linda L Magnusson Hanson, Eva Bojner Horwitz, Walter Osika
This study aims to identify any differences regarding gender, age, socioeconomic status (SES), self-rated health, perceived stress and the purchase of prescribed drugs among people who practice mind and body exercises (MBE) extensively compared to people who do not. METHODS: The study includes 3,913 men and 4,803 women aged 20-72 who participated in the Swedish Longitudinal Occupational Survey of Health (SLOSH). The respondents were divided into three groups depending on frequency of MBE practice (never/seldom/often)...
2017: PloS One
https://www.readbyqxmd.com/read/28826710/biomechanical-analysis-of-bilateral-facet-joint-stabilization-using-bioderived-tendon-for-posterior-cervical-spine-motion-reservation-in-goats
#16
Bei-Yu Wang, Ting-Kui Wu, Hao Liu, Wei-Guang Hou, Li-Tai Ma, Yu-Xiao Deng, Chen Ding, Ying Hong, Hui-Qi Xie
OBJECTIVES: To investigate the biomechanical properties of a novel stabilization method for posterior cervical motion preservation using bioderived freeze-dried tendon. METHODS: Experiments were conducted both in vitro and in vivo. For the in vitro group, 15 fresh-frozen goat spines (C1-C7) were randomly divided into 3 subgroups: intact (INT-vitro, n = 5), injury model (IM-vitro, n = 5), and bilateral facet joint stabilization (BFJS-vitro, n = 5) subgroups...
November 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28825707/satellite-to-ground-quantum-key-distribution
#17
Sheng-Kai Liao, Wen-Qi Cai, Wei-Yue Liu, Liang Zhang, Yang Li, Ji-Gang Ren, Juan Yin, Qi Shen, Yuan Cao, Zheng-Ping Li, Feng-Zhi Li, Xia-Wei Chen, Li-Hua Sun, Jian-Jun Jia, Jin-Cai Wu, Xiao-Jun Jiang, Jian-Feng Wang, Yong-Mei Huang, Qiang Wang, Yi-Lin Zhou, Lei Deng, Tao Xi, Lu Ma, Tai Hu, Qiang Zhang, Yu-Ao Chen, Nai-Le Liu, Xiang-Bin Wang, Zhen-Cai Zhu, Chao-Yang Lu, Rong Shu, Cheng-Zhi Peng, Jian-Yu Wang, Jian-Wei Pan
Quantum key distribution (QKD) uses individual light quanta in quantum superposition states to guarantee unconditional communication security between distant parties. However, the distance over which QKD is achievable has been limited to a few hundred kilometres, owing to the channel loss that occurs when using optical fibres or terrestrial free space that exponentially reduces the photon transmission rate. Satellite-based QKD has the potential to help to establish a global-scale quantum network, owing to the negligible photon loss and decoherence experienced in empty space...
September 7, 2017: Nature
https://www.readbyqxmd.com/read/28820652/decreasing-stroke-code-to-ct-time-in-patients-presenting-with-stroke-symptoms
#18
Aleksandrs Kalnins, L Jake Mickelsen, Daisha Marsh, Christoph Zorich, Stephanie Casal, Waimei Amy Tai, Nirali Vora, Gennette Olalia, Max Wintermark, David B Larson
Guided quality improvement (QI) programs present an effective means to streamline stroke code to computed tomography (CT) times in a comprehensive stroke center. Applying QI methods and a multidisciplinary team approach may decrease the stroke code to CT time in non-prenotified emergency department (ED) patients presenting with symptoms of stroke. The aim of this project was to decrease this time for non-prenotified stroke code patients from a baseline mean of 20 minutes to one less than 15 minutes during an 18-week period by applying QI methods in the context of a structured QI program...
September 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28798294/comparative-study-of-recessive-spherical-headed-silicone-intubation-and-endonasal-dacryocystorhinostomy-under-nasal-endoscopy-for-nasolacrimal-duct-obstruction
#19
Hui-Yi Deng, Tao Wang, Xue-Kun Huang, Qin-Tai Yang, Shi-Qi Ling, Wei-Hao Wang, Mei-Jiao Li, Fang-Qin Ning, Ge-Hua Zhang
Between July 2014 and November 2015, we compared the curative effects and cost-effectiveness of two kinds of nasal endoscopic surgery for nasolacrimal duct obstruction (NLDO) in a single-centre, two-armed clinical trial with a 1-year follow-up. We included two groups: a recessive spherical headed silicone intubation (RSHSI) group and an endonasal dacryocystorhinostomy (En-DCR) group; both received nasal endoscopy. Patients were recruited from the Otorhinolaryngology and Ophthalmology departments. The main outcome measures were epiphora improvement (classified as cure, effective, or invalid), cost-effectiveness, visual analogue scale (VAS) intraoperative pain score, bleeding volume, operating time, hospitalisation time, total cost, and VAS postoperative epiphora score...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28740383/enhanced-immunization-via-dissolving-microneedle-array-based-delivery-system-incorporating-subunit-vaccine-and-saponin-adjuvant
#20
Ji-Hui Zhao, Qi-Bo Zhang, Bao Liu, Xiang-Hua Piao, Yu-Lu Yan, Xiao-Ge Hu, Kuan Zhou, Yong-Tai Zhang, Nian-Ping Feng
PURPOSE: To enhance the immunogenicity of the model subunit vaccine, ovalbumin (OVA) was combined with platycodin (PD), a saponin adjuvant. To reduce the toxicity of PD, OVA, and adjuvant were loaded together into liposomes before being incorporated into a dissolving microneedle array. METHODS: OVA- and PD-loaded liposomes (OVA-PD-Lipos) were prepared using the film dispersion method. Their uptake behavior, toxicity to mouse bone marrow dendritic cells (BMDCs), and hemolytic activity to rabbit red blood cells (RBCs) were evaluated...
2017: International Journal of Nanomedicine
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