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https://www.readbyqxmd.com/read/29713157/effectiveness-of-meditative-movement-on-copd-a-systematic-review-and-meta-analysis
#1
REVIEW
Lu-Ling Wu, Zheng-Kun Lin, Hui-Dan Weng, Qiao-Fang Qi, Jun Lu, Kai-Xiong Liu
Background: The effectiveness of meditative movement (tai chi, yoga, and qigong) on COPD remained unclear. We undertook a systematic review and meta-analysis to determine the effectiveness of meditative movement on COPD patients. Methods: We searched PubMed, Web of Science, EMBASE, and the Cochrane Center Register of Controlled Trials for relevant studies. The methods of standard meta-analysis were utilized for identifying relevant researches (until August 2017), quality appraisal, and synthesis...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29687823/a-novel-pillar-5-arene-based-supramolecular-organic-framework-gel-to-achieve-an-ultrasensitive-response-by-introducing-the-competition-of-cation%C3%AF-and-%C3%AF-%C3%AF-interactions
#2
You-Ming Zhang, Yong-Fu Li, Kai-Peng Zhong, Wen-Juan Qu, Xiao-Peng Chen, Hong Yao, Tai-Bao Wei, Qi Lin
Ultrasensitive response properties are an intriguing concern for stimuli-responsive materials. Herein, we report a novel method to achieve an ultrasensitive response by introducing the competition of cationπ and ππ interactions into a pillar[5]arene-based supramolecular organic framework (SOF-AMP). SOF-AMP was constructed with a novel bis-naphthalimide functionalized pillar[5]arene, which was able to form a stable supramolecular gel (SOF-AMP-G) in cyclohexanol. Interestingly, SOF-AMP-G shows an ultrasensitive response to Fe3+ through the competition of cationπ and ππ interactions...
April 24, 2018: Soft Matter
https://www.readbyqxmd.com/read/29678829/draft-genome-sequence-of-camellia-sinensis-var-sinensis-provides-insights-into-the-evolution-of-the-tea-genome-and-tea-quality
#3
Chaoling Wei, Hua Yang, Songbo Wang, Jian Zhao, Chun Liu, Liping Gao, Enhua Xia, Ying Lu, Yuling Tai, Guangbiao She, Jun Sun, Haisheng Cao, Wei Tong, Qiang Gao, Yeyun Li, Weiwei Deng, Xiaolan Jiang, Wenzhao Wang, Qi Chen, Shihua Zhang, Haijing Li, Junlan Wu, Ping Wang, Penghui Li, Chengying Shi, Fengya Zheng, Jianbo Jian, Bei Huang, Dai Shan, Mingming Shi, Congbing Fang, Yi Yue, Fangdong Li, Daxiang Li, Shu Wei, Bin Han, Changjun Jiang, Ye Yin, Tao Xia, Zhengzhu Zhang, Jeffrey L Bennetzen, Shancen Zhao, Xiaochun Wan
Tea, one of the world's most important beverage crops, provides numerous secondary metabolites that account for its rich taste and health benefits. Here we present a high-quality sequence of the genome of tea, Camellia sinensis var. sinensis (CSS), using both Illumina and PacBio sequencing technologies. At least 64% of the 3.1-Gb genome assembly consists of repetitive sequences, and the rest yields 33,932 high-confidence predictions of encoded proteins. Divergence between two major lineages, CSS and Camellia sinensis var...
April 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29662974/competition-of-cation-%C3%AF-and-exo-wall-%C3%AF-%C3%AF-interactions-a-novel-approach-to-achieve-ultrasensitive-response
#4
You-Ming Zhang, Wei Zhu, Wen-Juan Qu, Kai-Peng Zhong, Xiao-Peng Chen, Hong Yao, Tai-Bao Wei, Qi Lin
A novel approach to achieve ultrasensitive response was successfully developed by rationally introducing the competition between cation-π and exo-wall π-π interactions into a pillar[5]arene-based supramolecular organogel (P5N-OG). Interestingly, the P5N-OG could be used for ion detection and separation, fluorescent display materials as well as ultrasensitive logic gates.
April 17, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29661715/expression-and-clinical-significance-of-retinoid-x-receptor-%C3%AE-in-esophageal-carcinoma
#5
Hong-Yue Ren, Yi-He Guo, Li-Min Yang, Tai-Jian Dai, Ming-Zhu Lin, Le Yu, Qi-Gan Zhu, Jia-Rong Meng
PURPOSE: Esophageal carcinoma (EC) is one of the most aggressive type cancers and dysregulation of retinoid X receptor α (RXRα) involves various tumors. However, the relationship of RXRα with the clinicopathological factors of EC, particularly prognostic characteristics, remains unclear. This present study was to evaluate the effect of RXRα expression in the development of EC. METHODS: The mRNA and protein expression level of RXRα in EC and normal esophageal tissues using reverse transcription-polymerase chain reaction (RT-PCR) and Western blot, respectively...
March 28, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29653232/gata6-loss-of-function-mutation-contributes-to-congenital-bicuspid-aortic-valve
#6
Ying-Jia Xu, Ruo-Min Di, Qi Qiao, Xiu-Mei Li, Ri-Tai Huang, Song Xue, Xing-Yuan Liu, Juan Wang, Yi-Qing Yang
Congenital bicuspid aortic valve (BAV), the most common form of birth defect in humans, is associated with substantial morbidity and mortality. Increasing evidence demonstrates that genetic risk factors play a key role in the pathogenesis of BAV. However, BAV is a genetically heterogeneous disease and the genetic determinants underpinning BAV in an overwhelming majority of patients remain unknown. In the present study, the coding exons and flanking introns of the GATA6 gene, which encodes a zinc-finger transcription factor essential for the normal development of the aortic valves, were sequenced in 152 unrelated patients with congenital BAV...
April 10, 2018: Gene
https://www.readbyqxmd.com/read/29650371/turo-qi-dance-program-for-parkinson-s-disease-patients-randomized-assessor-blind-waiting-list-control-partial-crossover-study
#7
Hwa-Jin Lee, Song-Yi Kim, Younbyoung Chae, Mi-Young Kim, Changshik Yin, Woo-Sang Jung, Ki-Ho Cho, Seung-Nam Kim, Hi-Joon Park, Hyejung Lee
CONTEXT: Qigong, Tai-chi and dancing have all been proven effective for Parkinson's disease (PD); however, no study has yet assessed the efficacy of Turo, a hybrid qigong dancing program developed to relieve symptoms in PD patients. OBJECTIVE: To determine whether Turo may provide benefit in addressing the symptoms of PD patients. DESIGN: Randomized, assessor blind, waiting-list control, partial crossover study. SETTING: Kyung Hee University Korean Medicine Hospital, Seoul, Republic of Korea...
March 1, 2018: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/29628305/mir-223-3p-inhibits-human-osteosarcoma-metastasis-and-progression-by-directly-targeting-cdh6
#8
Quanbo Ji, Xiaojie Xu, Qi Song, Yameng Xu, Yanhong Tai, Stuart B Goodman, Wenzhi Bi, Meng Xu, Shunchang Jiao, William J Maloney, Yan Wang
Cadherin-6 (CDH6) is aberrantly expressed in cancer and closely associated with tumor progression. However, the functions of CDH6 in human osteosarcoma and the molecular mechanisms underlying CDH6 in osteosarcoma oncogenesis remain poorly understood. In this work, we assessed the role of CDH6 in human osteosarcoma and identified that the expression of CDH6 was closely related with the overall survival and poor prognosis of osteosarcoma patients. MicroRNAs (miRNAs) have been implicated as important epigenetic regulators during the progression of osteosarcoma...
March 14, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29608289/aggregation-induced-electrochemiluminescence-from-a-cyclometalated-iridium-iii-complex
#9
Tai-Bao Gao, Jing-Jing Zhang, Run-Qi Yan, Deng-Ke Cao, Dechen Jiang, Deju Ye
Aggregation-induced emission has been extensively found in organic compounds and metal complexes. In contrast, aggregation-induced electrochemiluminescence (AI-ECL) is rarely observed. Here, we employ two tridentate ligands [2,2':6',2″-terpyridine (tpy) and 1,3-bis(1 H-benzimidazol-2-yl)benzene (bbbiH3 )] to construct a cyclometalated iridium(III) complex, [Ir(tpy)(bbbi)] (1), showing strong AI-ECL. Its crystal structure indicates that neighboring [Ir(tpy)(bbbi)] molecules are connected through both π-π-stacking interactions and hydrogen bonds...
April 2, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29581296/recombinant-immunotoxins-with-albumin-binding-domains-have-long-half-lives-and-high-antitumor-activity
#10
Junxia Wei, Tapan K Bera, Xiu Fen Liu, Qi Zhou, Masanori Onda, Mitchell Ho, Chin-Hsien Tai, Ira Pastan
Recombinant immunotoxins (RITs) are chimeric proteins consisting of a Fv that binds to a cancer cell and a portion of a protein toxin. One of these, Moxetumomab pasudotox, was shown to be effective in treating patients with some leukemias, where the cells are readily accessible to the RIT. However, their short half-life limits their efficacy in solid tumors, because penetration into the tumors is slow. Albumin and agents bound to albumin have a long half-life in the circulation. To increase the time tumor cells are exposed to RITs, we have produced and evaluated variants that contain either an albumin-binding domain (ABD) from Streptococcus or single-domain antibodies from Llama...
March 26, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29579301/functional-characteristics-of-phenolic-compounds-accumulated-in-young-leaves-of-two-subtropical-forest-tree-species-of-different-successional-stages
#11
Tai-Jie Zhang, Jin Zheng, Zheng-Chao Yu, Xuan-Dong Huang, Qi-Lei Zhang, Xing-Shan Tian, Chang-Lian Peng
The abundance of phenolic compounds (including anthocyanins) in leaves is associated with photosynthetic performance, but the regulatory mechanism is unclear. Schima superba Gardn. et Champ. and Cryptocarya concinna Hance., which exhibit distinct anthocyanin accumulation patterns, are dominant tree species in the early- and late-successional stages, respectively, of subtropical forests in China. RNA-seq and analyses of phenolic concentrations, antioxidant capacity and photosynthetic characteristics were performed on young and mature leaves of these two species under contrasting light conditions...
March 22, 2018: Tree Physiology
https://www.readbyqxmd.com/read/29556041/cancer-associated-fibroblasts-induce-pdl1-neutrophils-through-the-il6-stat3-pathway-that-foster-immune-suppression-in-hepatocellular-carcinoma
#12
Yusheng Cheng, Hui Li, Yinan Deng, Yan Tai, Kaining Zeng, Yingcai Zhang, Wei Liu, Qi Zhang, Yang Yang
Emerging evidence indicate that cancer-associated fibroblasts (CAFs) affect tumor progression by reshaping the tumor microenvironment. Neutrophils are prominent components of solid tumors and important in cancer progression. Whether the phenotype and function of neutrophils in hepatocellular carcinoma (HCC) are influenced by CAFs is not well understood. Herein, we investigated the effect of HCC-derived CAFs (HCC-CAFs) on the neutrophils and explored the biological role of this effect. We found that HCC-CAFs induced chemotaxis of neutrophils and protected them from spontaneous apoptosis...
March 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29484111/endurance-exercise-prevents-high-fat-diet-induced-heart-and-mobility-premature-aging-and-dsir-2-expression-decline-in-aging-drosophila
#13
Deng-Tai Wen, Lan Zheng, Fan Yang, Han-Zhe Li, Wen-Qi Hou
High-Fat-Diet (HFD)-induced obesity is a major contributor to heart and mobility premature aging and mortality in both Drosophila and humans. The dSir 2 genes are closely related to aging, but there are few directed reports showing that whether HFD could inhibit the expression dSir 2 genes. Endurance exercise can prevent fat accumulation and reverse HFD-induced cardiac dysfunction. Endurance also delays age-relate functional decline. It is unclear whether lifetime endurance exercise can combat lifetime HFD-induced heart and mobility premature aging, and relieve the harmful HFD-induced influence on the dSir 2 gene and lifespan yet...
January 26, 2018: Oncotarget
https://www.readbyqxmd.com/read/29457891/pd-catalyzed-asymmetric-dearomative-cycloaddition-for-construction-of-optically-active-pyrroloindoline-and-cyclopentaindoline-derivatives-access-to-3a-aminopyrroloindolines
#14
Jun-Qi Zhang, Feifei Tong, Bing-Bing Sun, Wei-Tai Fan, Jun-Bo Chen, Dandan Hu, Xing-Wang Wang
Asymmetric dearomative [3 + 2] cycloaddition reactions of 3-nitroindoles with vinyl aziridine and vinyl cyclopropanes have been respectively successfully developed in the presence of a chiral box/Pd(0) complex. A series of enantiomerically enriched 3a-nitro-hexahydropyrrolo[2,3-b]indole and 8b-nitrohexahydrocyclopenta[b]indole derivatives containing three contiguous chiral centers are smoothly obtained in high yields with satisfactory regio-, chemo-, and enantioselectivity. Remarkably, the synthetic utility of this process was demonstrated through direct reductive amination and functionalization of the carbon-carbon double bond of the desired products...
March 2, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29436645/ouabain-suppresses-the-growth-and-migration-abilities-of-glioma-u%C3%A2-87mg-cells-through-inhibiting-the-akt-mtor-signaling-pathway-and-downregulating-the-expression-of-hif%C3%A2-1%C3%AE
#15
Xiao-Sa Yang, Zhong-Wei Xu, Tai-Long Yi, Rui-Cheng Xu, Jie Li, Wen-Bin Zhang, Sai Zhang, Hong-Tao Sun, Ze-Qi Yu, Hao-Xiang Xu, Yue Tu, Shi-Xiang Cheng
Glioma is one of the most malignant forms of brain tumor, and has been of persistent concern due to its high recurrence and mortality rates, and limited therapeutic options. As a cardiac glycoside, ouabain has widespread applications in congestive heart diseases due to its positive cardiac inotropic effect by inhibiting Na+/K+‑ATPase. Previous studies have demonstrated that ouabain has antitumor activity in several types of human tumor, including glioma. However, the exact underlying mechanism remains to be elucidated...
April 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29435525/diastereodivergent-synthesis-of-bispirooxindoles-via-asymmetric-friedel-crafts-aldol-cascade-reaction-co-catalyst-effects-on-diastereoselective-outcomes
#16
Nai-Kai Li, Wei-Tai Fan, Jun-Qi Zhang, Bing-Bing Sun, Jun-Bo Chen, Xing-Wang Wang
A combination of metal- and organo-catalysts sequentially catalyzing the Friedel-Crafts/aldol tandem reaction between 3-pyrrolyl-oxindoles and isatin-derived β,γ-unsaturated α-ketoesters has been reported, which leads to two types of diastereomeric enantio-enriched bispirooxindoles with three quaternary stereocentres and synthetically valuable functional groups in high yields with excellent enantioselectivity and diastereoselectivity.
February 27, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29417319/retraction-note-enhanced-emission-of-quantum-system-in-si-ge-nanolayer-structure
#17
Zhong-Mei Huang, Wei-Qi Huang, Tai-Ge Dong, Gang Wang, Xue-Ke Wu
The Editor has retracted this article [1] due to significant overlap in text and figures with a previous article published in another journal [2]. The authors do not agree with the retraction.
February 7, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29400544/satellite-relayed-intercontinental-quantum-network
#18
Sheng-Kai Liao, Wen-Qi Cai, Johannes Handsteiner, Bo Liu, Juan Yin, Liang Zhang, Dominik Rauch, Matthias Fink, Ji-Gang Ren, Wei-Yue Liu, Yang Li, Qi Shen, Yuan Cao, Feng-Zhi Li, Jian-Feng Wang, Yong-Mei Huang, Lei Deng, Tao Xi, Lu Ma, Tai Hu, Li Li, Nai-Le Liu, Franz Koidl, Peiyuan Wang, Yu-Ao Chen, Xiang-Bin Wang, Michael Steindorfer, Georg Kirchner, Chao-Yang Lu, Rong Shu, Rupert Ursin, Thomas Scheidl, Cheng-Zhi Peng, Jian-Yu Wang, Anton Zeilinger, Jian-Wei Pan
We perform decoy-state quantum key distribution between a low-Earth-orbit satellite and multiple ground stations located in Xinglong, Nanshan, and Graz, which establish satellite-to-ground secure keys with ∼kHz rate per passage of the satellite Micius over a ground station. The satellite thus establishes a secure key between itself and, say, Xinglong, and another key between itself and, say, Graz. Then, upon request from the ground command, Micius acts as a trusted relay. It performs bitwise exclusive or operations between the two keys and relays the result to one of the ground stations...
January 19, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29393296/tamoxifen-enhances-stemness-and-promotes-metastasis-of-er%C3%AE-36-breast-cancer-by-upregulating-aldh1a1-in-cancer-cells
#19
Qiang Wang, Jun Jiang, Guoguang Ying, Xiao-Qing Xie, Xia Zhang, Wei Xu, Xuemin Zhang, Erwei Song, Hong Bu, Yi-Fang Ping, Xiao-Hong Yao, Bin Wang, Shilei Xu, Ze-Xuan Yan, Yanhong Tai, Baoquan Hu, Xiaowei Qi, Yan-Xia Wang, Zhi-Cheng He, Yan Wang, Ji Ming Wang, You-Hong Cui, Feng Chen, Kun Meng, Zhaoyi Wang, Xiu-Wu Bian
The 66 kDa estrogen receptor alpha (ERα66) is the main molecular target for endocrine therapy such as tamoxifen treatment. However, many patients develop resistance with unclear mechanisms. In a large cohort study of breast cancer patients who underwent surgery followed by tamoxifen treatment, we demonstrate that ERα36, a variant of ERα66, correlates with poor prognosis. Mechanistically, tamoxifen directly binds and activates ERα36 to enhance the stemness and metastasis of breast cancer cells via transcriptional stimulation of aldehyde dehydrogenase 1A1 (ALDH1A1)...
March 2018: Cell Research
https://www.readbyqxmd.com/read/29371696/hydrogen-water-ameliorates-radiation-induced-gastrointestinal-toxicity-via-myd88-s-effects-on-the-gut-microbiota
#20
Hui-Wen Xiao, Yuan Li, Dan Luo, Jia-Li Dong, Li-Xin Zhou, Shu-Yi Zhao, Qi-Sheng Zheng, Hai-Chao Wang, Ming Cui, Sai-Jun Fan
Although radiation therapy is a cornerstone of modern management of malignancies, various side effects are inevitably linked to abdominal and pelvic cancer after radiotherapy. Radiation-mediated gastrointestinal (GI) toxicity impairs the life quality of cancer survivors and even shortens their lifespan. Hydrogen has been shown to protect against tissue injuries caused by oxidative stress and excessive inflammation, but its effect on radiation-induced intestinal injury was previously unknown. In the present study, we found that oral gavage with hydrogen-water increased the survival rate and body weight of mice exposed to total abdominal irradiation (TAI); oral gavage with hydrogen-water was also associated with an improvement in GI tract function and the epithelial integrity of the small intestine...
January 26, 2018: Experimental & Molecular Medicine
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