keyword
MENU ▼
Read by QxMD icon Read
search

Antiaging therapy

keyword
https://www.readbyqxmd.com/read/27274231/current-application-of-phytocompound-based-nanocosmeceuticals-for-beauty-and-skin-therapy
#1
REVIEW
Palanivel Ganesan, Dong-Kug Choi
Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27235672/non-diabetic-clinical-applications-of-insulin
#2
Jyoti M Benni, Paragouda A Patil
BACKGROUND: Introducing a new drug to the market is a time-consuming process, is complex, and involves consumption of a lot of resources. Therefore, discovering new uses for the old drugs (i.e. drug repurposing) benefits the patients by providing them time-tested drugs. With developments in insulin therapy still happening, it is worth keeping up to date on trends in the use of this powerful glucose-lowering agent. The aim of this article is to explore the potential non-diabetic clinical applications of insulin...
September 1, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27222494/evaluating-the-quality-of-website-information-of-private-practice-clinics-offering-cell-therapies-in-japan
#3
Hidenori Kashihara, Takeo Nakayama, Taichi Hatta, Naomi Takahashi, Misao Fujita
BACKGROUND: Although the safety and effectiveness of stem cell therapies are yet to be proven, recent studies show that such therapies are being advertised with some questionable marketing techniques to effect positive portrayal of the therapies on the webpages of private-practice clinics to sell their therapies worldwide. In such context, those clinics communicate directly with consumers (patients and their family members) via the clinics' websites. Meanwhile, the Health Science Council at the Ministry of Health, Labour, and Welfare (MHLW) in Japan has pointed out noncompliance of some local clinics with the provisions concerning medical advertising in the Medical Care Act in the past...
2016: Interactive Journal of Medical Research
https://www.readbyqxmd.com/read/27208895/rapamycin-an-inhibitor-of-aging-emerges-from-the-soil-of-easter-island
#4
REVIEW
Sebastian I Arriola Apelo, Dudley W Lamming
Rapamycin (sirolimus) is a macrolide immunosuppressant that inhibits the mechanistic target of rapamycin (mTOR) protein kinase and extends lifespan in model organisms including mice. Although rapamycin is an FDA-approved drug for select indications, a diverse set of negative side effects may preclude its wide-scale deployment as an antiaging therapy. mTOR forms two different protein complexes, mTORC1 and mTORC2; the former is acutely sensitive to rapamycin whereas the latter is only chronically sensitive to rapamycin in vivo...
July 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27195075/metformin-decreases-reactive-oxygen-species-enhances-osteogenic-properties-of-adipose-derived-multipotent-mesenchymal-stem-cells-in-vitro-and-increases-bone-density-in-vivo
#5
Krzysztof Marycz, Krzysztof A Tomaszewski, Katarzyna Kornicka, Brandon Michael Henry, Sebastian Wroński, Jacek Tarasiuk, Monika Maredziak
Due to its pleiotropic effects, the commonly used drug metformin has gained renewed interest among medical researchers. While metformin is mainly used for the treatment of diabetes, recent studies suggest that it may have further application in anticancer and antiaging therapies. In this study, we investigated the proliferative potential, accumulation of oxidative stress factors, and osteogenic and adipogenic differentiation potential of mouse adipose-derived stem cells (MuASCs) isolated from mice treated with metformin for 8 weeks...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/26924404/a-clinical-rating-scale-for-the-assessment-of-facial-aging-in-indian-population
#6
Sumit Sen, Supriyo Choudhury, Anusree Gangopadhyay, Chinmay Halder, Projna Biswas, Atul Jain
BACKGROUND: Estimation of facial aging has assumed growing importance due to the advent of several antiaging therapies. Evidence-based estimation of global facial aging is often necessary, especially for validation of these treatment modalities. Most available methods are expensive and have been used in fair skinned individuals. AIM: We attempted to develop a clinical rating scale for the estimation of global facial aging applied on an Indian population which has brown to black skin...
March 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/26885791/superior-efficacy-of-an-herbal-based-cosmeceutical-compared-with-common-prescription-and-cosmetic-antiaging-therapies
#7
Carl R Thornfeldt, Ronald L Rizer
INTRODUCTION: Research has shown that a disrupted stratum corneum permeability barrier coupled with chronic inflammation induce signs of extrinsic aging (photoaging). An novel herbal-based three product cosmeceutical regimen used to reverse these two anomalies that does not contain retinol, soy, niacinamide, tea, L-ascorbic acid or esters, hydroxy acids, tocopherol, or growth factors was tested in six human clinical trials to determine effectiveness and safety in reversing photoaging...
February 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/26843110/klotho-gene-and-selective-serotonin-reuptake-inhibitors-response-to-treatment-in-late-life-major-depressive-disorder
#8
Giulia Paroni, Davide Seripa, Andrea Fontana, Grazia D'Onofrio, Carolina Gravina, Maria Urbano, Filomena Addante, Madia Lozupone, Massimiliano Copetti, Alberto Pilotto, Antonio Greco, Francesco Panza
Klotho protein, encoded by the Klotho gene (KL) at locus 13q12, is an antiaging hormone-like protein playing a pivotal role in cell metabolism homeostasis and associated to longevity and age-related diseases. In particular, altered cell metabolism in central nervous system may influence the behavior of serotoninergic neurons. The role of KL in the response to treatment with selective serotonin reuptake inhibitors (SSRIs) in late-life depressive syndromes and late-life major depressive disorder (MDD) is unclear...
February 3, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26790545/a-clinical-rating-scale-for-the-assessment-of-facial-aging-in-indian-population
#9
Sumit Sen, Supriyo Choudhury, Anusree Gangopadhyay, Chinmay Halder, Projna Biswas, Atul Jain
BACKGROUND: Estimation of facial aging has assumed growing importance due to the advent of several antiaging therapies. Evidence-based estimation of global facial aging is often necessary, especially for validation of these treatment modalities. Most available methods are expensive and have been used in fair skinned individuals. AIM: We attempted to develop a clinical rating scale for the estimation of global facial aging applied on an Indian population which has brown to black skin...
January 21, 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/26559258/soluble-serum-%C3%AE-klotho-is-a-potential-predictive-marker-of-disease-progression-in-clear-cell-renal-cell-carcinoma
#10
Margherita Gigante, Giuseppe Lucarelli, Chiara Divella, Giuseppe Stefano Netti, Paola Pontrelli, Cesira Cafiero, Giuseppe Grandaliano, Giuseppe Castellano, Monica Rutigliano, Giovanni Stallone, Carlo Bettocchi, Pasquale Ditonno, Loreto Gesualdo, Michele Battaglia, Elena Ranieri
Renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies, and clear cell RCC (ccRCC), that has a high metastatic index and high relapse rate, is the most common histological subtype. The identification of new biomarkers in ccRCC is fundamental for stratifying patients into prognostic risk groups and to guide therapy. The renoprotective antiaging gene, αKlotho, has recently been found to work as a tumor suppressor in different human cancers. Here, we evaluated αKlotho expression in tissue and serum of ccRCC patients and correlated it with disease progression...
November 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26315571/health-span-extending-activity-of-human-amniotic-membrane-and-adipose-tissue-derived-stem-cells-in-f344-rats
#11
Dajeong Kim, Jangbeen Kyung, Dongsun Park, Ehn-Kyoung Choi, Kwang Sei Kim, Kyungha Shin, Hangyoung Lee, Il Seob Shin, Sung Keun Kang, Jeong Chan Ra, Yun-Bae Kim
UNLABELLED: Aging brings about the progressive decline in cognitive function and physical activity, along with losses of stem cell population and function. Although transplantation of muscle-derived stem/progenitor cells extended the health span and life span of progeria mice, such effects in normal animals were not confirmed. Human amniotic membrane-derived mesenchymal stem cells (AMMSCs) or adipose tissue-derived mesenchymal stem cells (ADMSCs) (1×10(6) cells per rat) were intravenously transplanted to 10-month-old male F344 rats once a month throughout their lives...
October 2015: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/26236580/sirtuin-1-and-aging-theory-for-chronic-obstructive-pulmonary-disease
#12
REVIEW
V Conti, G Corbi, V Manzo, G Pelaia, A Filippelli, A Vatrella
Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that represents an increasing health problem, especially in the elderly population. Drug therapies are symptomatic and inadequate to contrast disease progression and mortality. Thus, there is an urgent need to clarify the molecular mechanisms responsible for this condition in order to identify new biomarkers and therapeutic targets. Processes including oxidant/antioxidant, protease/antiprotease, and proliferative/antiproliferative balance and control of inflammatory response become dysfunctional during aging as well as in COPD...
2015: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/26185518/thread-embedding-acupuncture-inhibits-ultraviolet-b-irradiation-induced-skin-photoaging-in-hairless-mice
#13
Yoon-Jung Kim, Ha-Neui Kim, Mi-Sook Shin, Byung-Tae Choi
Thread embedding acupuncture (TEA) is an acupuncture treatment applied to many diseases in Korean medical clinics because of its therapeutic effects by continuous stimulation to tissues. It has recently been used to enhance facial skin appearance and antiaging, but data from evidence-based medicine are limited. To investigate whether TEA therapy can inhibit skin photoaging by ultraviolet B (UVB) irradiation, we performed analyses for histology, histopathology, in situ zymography and western blot analysis in HR-1 hairless mice...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/26150497/quantification-of-biological-aging-in-young-adults
#14
Daniel W Belsky, Avshalom Caspi, Renate Houts, Harvey J Cohen, David L Corcoran, Andrea Danese, HonaLee Harrington, Salomon Israel, Morgan E Levine, Jonathan D Schaefer, Karen Sugden, Ben Williams, Anatoli I Yashin, Richie Poulton, Terrie E Moffitt
Antiaging therapies show promise in model organism research. Translation to humans is needed to address the challenges of an aging global population. Interventions to slow human aging will need to be applied to still-young individuals. However, most human aging research examines older adults, many with chronic disease. As a result, little is known about aging in young humans. We studied aging in 954 young humans, the Dunedin Study birth cohort, tracking multiple biomarkers across three time points spanning their third and fourth decades of life...
July 28, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26062128/quantitative-structure-antioxidant-activity-models-of-isoflavonoids-a-theoretical-study
#15
Gloria Castellano, Francisco Torrens
Seventeen isoflavonoids from isoflavone, isoflavanone and isoflavan classes are selected from Dalbergia parviflora. The ChEMBL database is representative from these molecules, most of which result highly drug-like. Binary rules appear risky for the selection of compounds with high antioxidant capacity in complementary xanthine/xanthine oxidase, ORAC, and DPPH model assays. Isoflavonoid structure-activity analysis shows the most important properties (log P, log D, pKa, QED, PSA, NH + OH ≈ HBD, N + O ≈ HBA)...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/25930623/prescribing-of-u-s-food-and-drug-administration-approved-and-non-approved-compounded-menopausal-hormone-therapy-differs-by-specialty-25
#16
Ginger Constantine, Brian Bernick, Mitchell Krassan, Sebsatian Mirkin
INTRODUCTION: Use of U.S. Food and Drug Administration (FDA)-approved menopausal hormone therapy (HT) has decreased, whereas use of compounded non-FDA-approved menopausal HT has increased. Recently, legislation was enacted to curb prescriptions of compounded products when FDA-approved products exist. METHODS: A total of 9,001 U.S. physicians were invited to participate in a survey to collect their menopausal HT-prescribing patterns. Of 893 respondents, 440 were eligible based on menopausal HT prescriptions of FDA-approved and compounded non-FDA-approved to more than six patients per month and 425 were categorized as general practice, internal medicine and family practice (n=171); obstetrician-gynecologists (ob-gyns) (n=170); or wellness physicians (n=84)...
May 2015: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/25861371/establishment-of-a-comprehensive-list-of-candidate-antiaging-medicinal-herb-used-in-korean-medicine-by-text-mining-of-the-classical-korean-medical-literature-dongeuibogam-and-preliminary-evaluation-of-the-antiaging-effects-of-these-herbs
#17
Moo Jin Choi, Byung Tae Choi, Hwa Kyoung Shin, Byung Cheul Shin, Yoo Kyoung Han, Jin Ung Baek
The major objectives of this study were to provide a list of candidate antiaging medicinal herbs that have been widely utilized in Korean medicine and to organize preliminary data for the benefit of experimental and clinical researchers to develop new drug therapies by analyzing previous studies. "Dongeuibogam," a representative source of the Korean medicine literature, was selected to investigate candidate antiaging medicinal herbs and to identify appropriate terms that describe the specific antiaging effects that these herbs are predicted to elicit...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/25844614/evaluation-of-a-novel-home-skin-care-platform
#18
RANDOMIZED CONTROLLED TRIAL
Hilary C Reich, Irmina Wallander, Lacie Schulte, Lacie Shulte, Hilary Frickman, Suzanne Flickenger, Brian Zelickson
The home beauty device market is rapidly growing, having more than tripled in the last four years. This study evaluates several specific attachment heads using a novel home skincare platform (HSP). By incorporating multiple treatment heads for cleansing, skin smoothing, and skin infusion, this device has the potential to address many potential treatment goals. The first subset of this study is a blinded, randomized split-face study evaluating the efficacy of the HSP device with a standard brush head for make-up removal and compares the HSP device to a currently marketed home cleansing device...
April 2015: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/25802727/vildagliptin-vs-liraglutide-as-a-second-line-therapy-switched-from-sitagliptin-based-regimens-in-patients-with-type-2-diabetes-a-randomized-parallel-group-study
#19
Yumie Takeshita, Toshinari Takamura, Yuki Kita, Toshiki Otoda, Ken-Ichiro Kato, Hitomi Wakakuri, Masayuki Yamada, Hirofumi Misu, Yukiko Matsushima, Shuichi Kaneko
INTRODUCTION: A step-up strategy for dipeptidyl peptidase (DPP)-4 inhibitor-based regimens has not yet been established. In addition, similarities and differences between DPP-4 inhibitors and glucagon-like peptide (GLP)-1 receptor agonists remain to be elucidated in humans. We investigated the pleiotropic effects of vildagliptin vs liraglutide in patients with type 2 diabetes on sitagliptin-based regimens in an open-label, randomized, clinical trial. MATERIALS AND METHODS: A total of 122 patients with type 2 diabetes that was inadequately controlled by sitagliptin-based regimens were randomly assigned to either vildagliptin (50 mg, twice daily) or liraglutide treatment (0...
March 2015: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/25786397/the-synergistic-effects-of-chinese-herb-and-injectable-calcium-silicate-%C3%AE-tricalcium-phosphate-composite-on-an-osteogenic-accelerator-in-vitro
#20
Ming-Hsien Huang, Chia-Tze Kao, Yi-Wen Chen, Tuan-Ti Hsu, Den-En Shieh, Tsui-Hsien Huang, Ming-You Shie
This study investigates the physicochemical and biological effects of traditional Chinese medicines on the β-tricalcium phosphate (β-TCP)/calcium silicate (CS) composites of bone cells using human dental pulp cell. CS is an osteoconductive and bioactive material. For this research we have combined β-TCP and CS and check its effectiveness, a series of β-TCP/CS composites with different ratios of Xu Duan (XD) were prepared to make new bioactive and biodegradable biocomposites for bone repair. XD has been used in Traditional Chinese Medicine for hundreds of years as an antiosteoporosis, tonic and antiaging agent for the therapy of low back pain, traumatic hematoma, threatened abortion and bone fractures...
April 2015: Journal of Materials Science. Materials in Medicine
keyword
keyword
43058
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"