Beomgu Lee, Jong Seong Roh, Hoim Jeong, Yerin Kim, Jihyeon Lee, Changun Yun, Jiyoung Park, Da-Sol Kim, Jungsoo Lee, Min Wook So, Aran Kim, Dong Hyun Sohn, Seung-Geun Lee
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by skin and internal organ fibrosis and obliterative vasculopathy. Few effective treatments are currently available for fibrosis in SSc, therefore, demand persists for novel therapies. Although use of Ginkgo biloba extract (GBE) has been reported to improve blood circulation and alleviate liver and lung fibrosis, its effect on skin fibrosis in SSc remains unclear. In this study, the effects and underlying mechanisms of GBE on skin fibrosis in bleomycin (BLM)-induced mouse model of SSc was investigated...
2024: Animal Cells and Systems