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https://www.readbyqxmd.com/read/29454041/potential-risks-of-zika-and-chikungunya-outbreaks-in-brazil-a-modelling-study
#1
Breno S Aguiar, Camila Lorenz, Flávia Virginio, Lincoln Suesdek, Francisco Chiaravalloti-Neto
OBJECTIVES: While Brazil has witnessed an unprecedented Zika (ZIK) epidemic, in recent times, Chikungunya (CHIK) has also come into prominence as a threat, in the Americas. We aimed to identify the regions with increased probabilities of ZIK and CHIK occurrence, based on environmental and social conditions. METHODS: To assess the potential spatial risk of ZIK and CHIK dissemination, we used a statistical Maxent model, which considered the number of probable autochthonous ZIK and CHIK cases, in 2015 and 2016, with environmental variables and social indicators...
February 14, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29452849/bacterial-communities-in-mining-soils-and-surrounding-areas-under-regeneration-process-in-a-former-ore-mine
#2
Camila Cesário Fernandes, Luciano Takeshi Kishi, Erica Mendes Lopes, Wellington Pine Omori, Jackson Antonio Marcondes de Souza, Lucia Maria Carareto Alves, Eliana Gertrudes de Macedo Lemos
Human activities on the Earth's surface change the landscape of natural ecosystems. Mining practices are one of the most severe human activities, drastically altering the chemical, physical and biological properties of the soil environment. Bacterial communities in soil play an important role in the maintenance of ecological relationships. This work shows bacterial diversity, metabolic repertoire and physiological behavior in five ecosystems samples with different levels of impact. These ecosystems belong to a historical area in Iron Quadrangle, Minas Gerais, Brazil, which suffered mining activities until its total depletion without recovery since today...
February 13, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29452188/phosphate-fertilization-changes-the-characteristics-of-ma%C3%A3-%C3%A3-banana-starch
#3
Camila de Barros Mesquita, Émerson Loli Garcia, Ana Carolina Batista Bolfarini, Sarita Leonel, Célia Maria L Franco, Magali Leonel
The unripe banana has been studied as a potential source of starch for use in various applications. Considering the importance of phosphorus in the biosynthesis of the starch and also the interference of this mineral in starch properties, in this study it was evaluated the effect of rates of phosphate fertilizer applied in the cultivation of 'Maçã' banana on the characteristics of the starch. Starches extracted from fruits from different treatments were analyzed for morphological characteristics, X-ray diffraction pattern, relative crystallinity, granule size, amylose, resistant starch and phosphorus levels, as well as, for pasting and thermal properties...
February 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29451006/different-indexes-of-glycemic-variability-as-identifiers-of-patients-with-risk-of-hypoglycemia-in-type-2-diabetes-mellitus
#4
Ana M Gómez, Oscar M Muñoz, Alejandro Marin, Maria Camila Fonseca, Martin Rondon, María Alejandra Robledo Gómez, Andrei Sanko, Dilcia Lujan, Maira García-Jaramillo, Fabian Mauricio León Vargas
INTRODUCTION: Recent publications frequently introduce new indexes to measure glycemic variability (GV), quality of glycemic control, or glycemic risk; however, there is a lack of evidence supporting the use of one particular parameter, especially in clinical practice. METHODS: A cohort of type 2 diabetes mellitus (T2DM) patients in ambulatory care were followed using continuous glucose monitoring sensors (CGM). Mean glucose (MG), standard deviation, coefficient of variation (CV), interquartile range, CONGA1, 2, and 4, MAGE, M value, J index, high blood glucose index, and low blood glucose index (LBGI) were estimated...
February 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29450980/prediction-of-enteric-methane-production-yield-and-intensity-in-dairy-cattle-using-an-intercontinental-database
#5
Mutian Niu, Ermias Kebreab, Alexander N Hristov, Joonpyo Oh, Claudia Arndt, André Bannink, Ali R Bayat, André F Brito, Tommy Boland, David Casper, Les A Crompton, Jan Dijkstra, Maguy A Eugène, Phil C Garnsworthy, Md Najmul Haque, Anne L F Hellwing, Pekka Huhtanen, Michael Kreuzer, Bjoern Kuhla, Peter Lund, Jørgen Madsen, Cécile Martin, Shelby C McClelland, Mark McGee, Peter J Moate, Stefan Muetzel, Camila Muñoz, Padraig O'Kiely, Nico Peiren, Christopher K Reynolds, Angela Schwarm, Kevin J Shingfield, Tonje M Storlien, Martin R Weisbjerg, David R Yáñez-Ruiz, Zhongtang Yu
Enteric methane (CH 4 ) production from cattle contributes to global greenhouse gas emissions. Measurement of enteric CH 4 is complex, expensive and impractical at large scales; therefore, models are commonly used to predict CH 4 production. However, building robust prediction models requires extensive data from animals under different management systems worldwide. The objectives of this study were to (1) collate a global database of enteric CH 4 production from individual lactating dairy cattle; (2) determine the availability of key variables for predicting enteric CH 4 production (g/d per cow), yield [g/kg dry matter intake (DMI)], and intensity (g/kg energy corrected milk) and their respective relationships; (3) develop intercontinental and regional models and cross-validate their performance; and (4) assess the trade-off between availability of on-farm inputs and CH 4 prediction accuracy...
February 16, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29450671/short-term-treatment-with-metformin-reduces-hepatic-lipid-accumulation-but-induces-liver-inflammation-in-obese-mice
#6
Alexandre Abilio de Souza Teixeira, Camila O Souza, Luana A Biondo, Loreana Sanches Silveira, Edson A Lima, Helena A Batatinha, Adriane Pereira Araujo, Michele Joana Alves, Sandro Massao Hirabara, Rui Curi, José Cesar Rosa Neto
The study aimed to evaluate the metabolic and inflammatory effects of short-term treatments (10 days) with metformin (MET) on the NAFLD caused by a high-fat diet (HFD) in C57BL/6 mice. After the treatment, histological liver slices were obtained, hepatocytes and macrophages were extracted and cultured with phosphate buffered saline, LPS (2.5 µg/mL) and MET (1 µM) for 24 h. Cytokine levels were determined by ELISA. NAFLD caused by the HFD was partially reduced by MET. The lipid accumulation induced by the HFD was not associated with liver inflammation; however, MET seemed to promote pro-inflammatory effects in liver, since it increased hepatic concentration of IL-1β, TNF-α, IL-6, MCP-1 and IFN-γ...
February 15, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29450664/radiographic-study-of-mandibular-third-molars-evaluation-of-the-position-and-root-anatomy-in-brazilian-population
#7
Marcelo Bonifácio da Silva Sampieri, Francisca Lívia Parente Viana, Camila Lopes Cardoso, Márcia Ferreira Vasconcelos, Maria Helena Ferreira Vasconcelos, Eduardo Sanches Gonçales
OBJECTIVES: The root anatomy and position of mandibular third molars are important factors in assessing the level of difficulty of surgical removal procedures. In this light, this study aims to identify the most frequent position and the root anatomy of mandibular third molars. METHODS: The study sample comprised 1205 mandibular third molars from 710 panoramic radiographs evaluated. Regarding the position, all of them were based on Pell and Gregory's and Winter's classifications...
February 15, 2018: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29448199/insights-on-the-criteria-of-selection-of-vegetable-and-mineral-dielectric-fluids-used-in-power-transformers-on-the-basis-of-their-biodegradability-and-toxicity-assessments
#8
Aparecido Nivaldo Módenes, Karina Sanderson, Daniela Estelita Goes Trigueros, Adilson Ricken Schuelter, Fernando Rodolfo Espinoza-Quiñones, Camila Vargas Neves, Luiz Antônio Zanão Junior, Alexander Dimitrov Kroumov
Leakage of transformer dielectric fluids is a concern because it may pose a risk of environmental contamination. In this study, the deleterious effects of vegetable and mineral dielectric fluids in water bodies were investigated using biodegradability and acute toxicity tests with Danio rerio and Artemia salina. Regarding biodegradability, all four tested vegetable oils (soy, canola, sunflower and crambe) were considered as easily biodegradable, presenting degradation rates significantly higher than the Lubrax-type mineral fluid...
February 7, 2018: Chemosphere
https://www.readbyqxmd.com/read/29445114/kinesin-1-regulates-cilia-length-through-an-interaction-with-the-bardet-biedl-syndrome-related-protein-ccdc28b
#9
Rossina Novas, Magdalena Cardenas-Rodriguez, Paola Lepanto, Matías Fabregat, Magela Rodao, María Inés Fariello, Mauricio Ramos, Camila Davison, Gabriela Casanova, Lucía Alfaya, Federico Lecumberry, Gualberto González-Sapienza, Florencia Irigoín, Jose L Badano
Bardet-Biedl syndrome (BBS) is a ciliopathy characterized by retinal degeneration, obesity, polydactyly, renal disease and mental retardation. CCDC28B is a BBS-associated protein that we have previously shown plays a role in cilia length regulation whereby its depletion results in shortened cilia both in cells and Danio rerio (zebrafish). At least part of that role is achieved by its interaction with the mTORC2 component SIN1, but the mechanistic details of this interaction and/or additional functions that CCDC28B might play in the context of cilia remain poorly understood...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444451/risk-factors-for-neonatal-death-in-the-capital-city-with-the-lowest-infant-mortality-rate-in-brazil
#10
Leandro Pereira Garcia, Camila Mariano Fernandes, Jefferson Traebert
OBJECTIVES: To analyze the risk factors for neonatal death in Florianópolis, the Brazilian city capital with the lowest infant mortality rate. METHOD: Data were extracted from a historical cohort with 15,879 live births. A model was used that included socioeconomic, behavioral, and health service use risk factors, as well as the Apgar score and biological factors. Risk factors were analyzed by hierarchical logistic regression. RESULTS: Based on the multivariate analysis, socioeconomic factors showed no association with death...
February 11, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29442800/characterization-of-articaine-loaded-poly-%C3%AE%C2%B5-caprolactone-nanocapsules-and-solid-lipid-nanoparticles-in-hydrogels-for-topical-formulations
#11
Nathalie Ferreira Silva de Melo, Estefânia Vangelie Ramos Campos, Michelle Franz-Montan, Eneida de Paula, Camila Morais Gonçalves da Silva, Cíntia Rodrigues Maruyama, Tatiane Pasquoto Stigliani, Renata de Lima, Daniele Ribeiro de Araújo, Leonardo Fernandes Fraceto
This work describes the development of poly-ε-caprolactone nanocapsules (PCL-NC) and solid lipid nanoparticles (SLN) aiming delivery for articaine (ATC), in order to improve its chemical stability in semi-solid preparations looking forward their use for skin delivery. The nanoparticles were characterized by size, polydispersity index, and pH. Cellular viability was evaluated using the MTT test and the in vitro release kinetics was determined using a two-compartment model. The hydrogels with nanoparticle suspensions were characterized considering their rheological aspects and in vitro permeation across artificial membranes...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29441327/inorganic-polyphosphate-is-essential-for-salmonella-typhimurium-virulence-and-survival-in-dictyostelium-discoideum
#12
Macarena A Varas, Sebastián Riquelme-Barrios, Camila Valenzuela, Andrés E Marcoleta, Camilo Berríos-Pastén, Carlos A Santiviago, Francisco P Chávez
Inorganic polyphosphate (polyP) deficiency in enteric bacterial pathogens reduces their ability to invade and establish systemic infections in different hosts. For instance, inactivation of the polyP kinase gene ( ppk ) encoding the enzyme responsible for polyP biosynthesis reduces invasiveness and intracellular survival of Salmonella enterica serovar Typhimurium ( S . Typhimurium) in epithelial cells and macrophages in vitro . In addition, the virulence in vivo of a S . Typhimurium Δ ppk mutant is significantly reduced in a murine infection model...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29440640/21st-century-drought-related-fires-counteract-the-decline-of-amazon-deforestation-carbon-emissions
#13
Luiz E O C Aragão, Liana O Anderson, Marisa G Fonseca, Thais M Rosan, Laura B Vedovato, Fabien H Wagner, Camila V J Silva, Celso H L Silva Junior, Egidio Arai, Ana P Aguiar, Jos Barlow, Erika Berenguer, Merritt N Deeter, Lucas G Domingues, Luciana Gatti, Manuel Gloor, Yadvinder Malhi, Jose A Marengo, John B Miller, Oliver L Phillips, Sassan Saatchi
Tropical carbon emissions are largely derived from direct forest clearing processes. Yet, emissions from drought-induced forest fires are, usually, not included in national-level carbon emission inventories. Here we examine Brazilian Amazon drought impacts on fire incidence and associated forest fire carbon emissions over the period 2003-2015. We show that despite a 76% decline in deforestation rates over the past 13 years, fire incidence increased by 36% during the 2015 drought compared to the preceding 12 years...
February 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29439936/use-of-pdc1-inh-concentrate-for-long-term-prophylaxis-during-pregnancy-in-hereditary-angioedema-with-normal-c1-inh
#14
Juliana F B Garcia, Priscila Takejima, Camila Lopes Veronez, Marcelo V Aun, Antonio A Motta, Jorge Kalil, João Bosco Pesquero, Pedro Giavina-Bianchi
No abstract text is available yet for this article.
February 10, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29439276/mannose-binding-lectin2-gene-polymorphism-and-igg4-in-membranous-nephropathy
#15
Denise Maria do Nascimento Costa, Lucila Maria Valente, Gisele Vajgel Fernandes, Paula Sandrin-Garcia, Heidi Lacerda Alves da Cruz, Sergio Crovella, Antônio Henrique Santana Cavalcante, Maria Alina Gomes de Mattos Cavalcante, Camila Barbosa Lyra de Oliveira, Carolina de Andrade Jordão de Vasconcelos, Emanuel Sávio Cavalcante Sarinho
BACKGROUND: Idiopathic membranous nephropathy (IMN) has been linked to the lectin pathway, IgG4 and genetic susceptibility. We investigated the frequency of mannose-binding lectin2 (MBL2) gene polymorphisms and the serum ratio of IgG4 in patients with membranous nephropathy (MN). METHODS: Polymorphisms in the exon 1 of the MBL2 gene (codons 52, 54, and 57) and single base polymorphisms at positions -550 (HL) and -221 (XY) in the promoter region were evaluated in 60 patients compared to a control group (CG) of 101 blood donors...
February 13, 2018: Nephron
https://www.readbyqxmd.com/read/29439176/skeletal-muscle-quality-beyond-average-muscle-attenuation-a-proposal-of-skeletal-muscle-phenotypes-to-predict-short-term-survival-in-patients-with-endometrial-cancer
#16
Camila Santos Rodrigues, Gabriela Villaça Chaves
Background: Increasing evidence links sarcopenia and cancer prognosis, but limited data have focused on whether and to what extent muscle radiodensity can impact cancer outcomes. This study was conducted to investigate whether skeletal muscle mass, when divided into subranges of low or high radiodensity, improves prediction of short-term survival in patients with endometrial cancer (EC). Four skeletal muscle phenotypes were proposed to assess which is the best predictor of 1-year mortality. Methods: Patients with EC who had CT images available within 30 days before treatment (n=208) were enrolled in a retrospective cohort...
February 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29438867/evaluation-of-the-microscopic-distribution-of-florfenicol-in-feed-pellets-for-salmon-by-fourier-transform-infrared-imaging-and-multivariate-analysis
#17
Camila Y Bastidas, Carlos von Plessing, José Troncoso, Rosario Del P Castillo
Fourier Transform infrared imaging and multivariate analysis were used to identify, at the microscopic level, the presence of florfenicol (FF), a heavily-used antibiotic in the salmon industry, supplied to fishes in feed pellets for the treatment of salmonid rickettsial septicemia (SRS). The FF distribution was evaluated using Principal Component Analysis (PCA) and Augmented Multivariate Curve Resolution with Alternating Least Squares (augmented MCR-ALS) on the spectra obtained from images with pixel sizes of 6...
February 7, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29437913/comparison-of-different-histological-indexes-in-the-assessment-of-uc-activity-and-their-accuracy-regarding-endoscopic-outcomes-and-faecal-calprotectin-levels
#18
Fernando Magro, Joanne Lopes, Paula Borralho, Susana Lopes, Rosa Coelho, José Cotter, Francisca Dias de Castro, Helena Tavares de Sousa, Marta Salgado, Patrícia Andrade, Ana Isabel Vieira, Pedro Figueiredo, Paulo Caldeira, A Sousa, Maria A Duarte, Filipa Ávila, João Silva, Joana Moleiro, Sofia Mendes, Sílvia Giestas, Paula Ministro, Paula Sousa, Raquel Gonçalves, Bruno Gonçalves, Ana Oliveira, Isadora Rosa, Marta Rodrigues, Cristina Chagas, Cláudia Camila Dias, Joana Afonso, Karel Geboes, Fátima Carneiro
OBJECTIVE: Histological remission is being increasingly acknowledged as a therapeutic endpoint in patients with UC. The work hereafter described aimed to evaluate the concordance between three histological classification systems-Geboes Score (GS), Nancy Index (NI) and RobartsHistopathologyIndex (RHI), as well as to evaluate their association with the endoscopic outcomes and the faecal calprotectin (FC) levels. DESIGN: Biopsy samples from 377 patients with UC were blindly evaluated using GS, NI and RHI...
February 3, 2018: Gut
https://www.readbyqxmd.com/read/29437107/complete-closed-genome-sequence-of-nontoxigenic-invasive-corynebacterium-diphtheriae-bv-mitis-strain-iss-3319
#19
Camila Azevedo Antunes, Emily J Richardson, Joshua Quick, Pablo Fuentes-Utrilla, Georgia L Isom, Emily C Goodall, Jens Möller, Paul A Hoskisson, Ana Luiza Mattos-Guaraldi, Adam F Cunningham, Nicholas J Loman, Vartul Sangal, Andreas Burkovski, Ian R Henderson
The genome sequence of the human pathogen Corynebacterium diphtheriae bv. mitis strain ISS 3319 was determined and closed in this study. The genome is estimated to have 2,404,936 bp encoding 2,257 proteins. This strain also possesses a plasmid of 1,960 bp.
February 1, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29437049/ophthalmologic-manifestations-associated-with-zika-virus-infection
#20
Camila V Ventura, Liana O Ventura
Vision plays an important role in the development of communication, social interaction, spatial awareness, and the motor skills needed to explore the environment. In the past 2 years, researchers have described the broad spectrum of clinical features that comprise congenital Zika syndrome (CZS). The ocular manifestations are considered 1 important pillar of this new entity. The most characteristic ophthalmic findings include chorioretinal scars and focal pigmentary changes seen in the macular region. Since these findings were first reported, other researchers have validated and extended them, leading to a more complete picture of the spectrum of ocular manifestations related to CZS...
February 2018: Pediatrics
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