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Panos Theofilas, Alexander J Ehrenberg, Austin Nguy, Julia M Thackrey, Sara Dunlop, Maria B Mejia, Ana T Alho, Renata Elaine Paraizo Leite, Roberta Diehl Rodriguez, Claudia K Suemoto, Camila F Nascimento, Marcus Chin, Daniel Medina-Cleghorn, Ana Maria Cuervo, Michelle Arkin, William W Seeley, Bruce L Miller, Ricardo Nitrini, Carlos Augusto Pasqualucci, Wilson Jacob Filho, Udo Rueb, John Neuhaus, Helmut Heinsen, Lea T Grinberg
Clarifying the mechanisms connecting neurofibrillary tangle (NFT) neurotoxicity to neuronal dysfunction in humans is likely to be pivotal for developing effective treatments for Alzheimer's disease (AD). To model the temporal progression of AD in humans, we used a collection of brains with controls and individuals from each Braak stage to quantitatively investigate the correlation between intraneuronal caspase activation or macroautophagy markers, NFT burden, and neuronal loss, in the dorsal raphe nucleus and locus coeruleus, the earliest vulnerable areas to NFT accumulation...
September 20, 2017: Neurobiology of Aging
Helena Fabbri-Scallet, Maricilda Palandi de Mello, Gil Guerra-Júnior, Andréa Trevas Maciel-Guerra, Juliana Gabriel Ribeiro de Andrade, Camila Maia Costa de Queiroz, Isabella Lopes Monlleó, Dagmar Struve, Olaf Hiort, Ralf Werner
Steroidogenic factor-1 (SF1), encoded by the NR5A1 gene, is a key regulator of steroidogenesis and reproductive development. NR5A1 mutations described in 46,XY patients with disorder of sex development (DSD) can be associated with a range of conditions of phenotypes, however the genotype-phenotype correlation remains elusive in many cases. In the present study, we describe the impact of five NR5A1 variants (three novel: p.Arg39Cys, p.Ser32Asn and p.Lys396Argfs*34; and two previously described: p.Cys65Tyr and p...
October 13, 2017: Human Mutation
Leonardo Henrique Perinotto Abdalla, Benedito Sérgio Denadai, Natalia Menezes Bassan, Camila Coelho Greco
The objective of this study was to test the hypotheses that end-test torque (ET) (expressed as % maximal voluntary contraction - MVC) is higher for plantar flexors (PF) than knee extensors (KE) muscles, whereas impulse above ET (IET) is higher for KE than PF. Thus, we expected that exercise tolerance would be longer for KE than PF only during the exercise performed above ET. After the determination of MVC, forty men performed two 5-min all-out tests to determine ET and IET. Eleven participants performed a further four intermittent isometric tests, to exhaustion, at ET + 5% and ET - 5%, and one test for KE at the exercise intensity (%MVC) corresponding to ET + 5% of PF...
October 12, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Camila Maciel de Oliveira, Anderson Zampier Ulbrich, Felipe Silva Neves, Fernando Augusto Lavezzo Dias, Andréa Roseli Vançan Russo Horimoto, José Eduardo Krieger, Rafael de Oliveira Alvim, Alexandre da Costa Pereira
BACKGROUND: Recently, some studies have evaluated the role of adiposity measures in the prediction of hypertension risk, but the results are conflicting. Thus, the aim of this study was to compare which of the four indicators of adiposity (waist circumference-WC, body mass index-BMI, body adiposity index-BAI, and visceral adiposity index-VAI) were better associated with hypertension in a Brazilian population. METHODS AND FINDINGS: For this study, were selected 1627 individuals (both genders, and aged over 18 years) resident in the municipality of Baependi, a city located in the Southeast of Brazil...
2017: PloS One
Verônica França Diniz Rocha, Adriano Hasler Principe de Oliveira, Antonio Carlos Bandeira, Silvia Ines Sardi, Rodrigo Freaza Garcia, Samuel de Araújo Magalhães, Camila Alves Sampaio, Gubio Campos Soares
Chikungunya virus (CHIKV) is an RNA virus transmitted by Aedes mosquitoes. The clinical manifestations include fever, arthralgia, rash, and other atypical clinical findings including ocular lesions. We report the case of a 57-year-old man with meningoencephalitis and anterior uveitis due to CHIKV. The patient had developed bilateral anterior uveitis with iris atrophy and a cotton wool spot on the left eye, and his serum, urine, saliva, and cerebrospinal fluid were positive for CHIKV by RT-PCR. The spectrum of the ophthalmologic manifestations and its pathophysiology in cases of CHIKV infections needs to be better understood...
October 11, 2017: Ocular Immunology and Inflammation
Camila González-Beiras, August Kapa, Marti Vall Mayans, Raymond Paru, Sergi Gavilán, Wendy Houinei, Sibauk Bieb, Sergi Sanz, Rosario Martíns, Oriol Mitjà
Background: Haemophilus ducreyi (HD) and Treponema pallidum subsp. pertenue (TP) are major causative agents of cutaneous ulcers (CU) in the tropics. Azithromycin is recommended to treat sexually transmitted HD infections and has good in-vitro activity against HD strains from both genital and skin ulcers. We investigated the efficacy of single oral dose azithromycin on HD-CU. Methods: We conducted a community-based cohort study in Lihir Island, Papua New Guinea, from October 2014 through May 2016...
August 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Haniel Cedraz, Juliana Gracielle Gonzaga Gromboni, Antonio Amandio Pinto Garcia, Ronaldo Vasconcelos Farias Filho, Teillor Machado Souza, Eduardo Ribeiro de Oliveira, Elizangela Bonfim de Oliveira, Carlos Souza do Nascimento, Camila Meneghetti, Amauri Arias Wenceslau
BACKGROUND: Chickens are animals that are sensitive to thermal stress, which may decrease their production level in terms that it affects feed intake and thus, decreasing body weight gain. The Heat Shock Factors (HSF) and Heat Shock Proteins (HSP) genes are involved in the key cellular defense mechanisms during exposure in hot environments. Aimed with this study to analyze the expression of HSF1, HSF3, HSP70 and HSP90 genes in two local breeds (Peloco and Caneluda) and a commercial broiler line (Cobb 500®) to verify differences in resistance of these chicken to Heat stress treatment...
2017: PloS One
Octávio Antonio Azevedo da Costa, Jurandir Marcondes Ribas, Bruno Luiz Ariede, Tereza Cavalcanti, João Guilherme Seifert Scapini, Camila Vitola Pasetto
OBJECTIVE: to evaluate the efficacy of three immunohistochemical markers involved in the wound healing process. METHODS: experimental study of 40 Wistar rats of the markers metalloproteinases and matrix metalloproteinase 9 (MMP-9), beta transforming growth factor (TGF-β) and myofibroblasts and smooth muscle actin alpha (α-MLA) markers, studied from fragments of surgical scar of abdominal incision involving skin, aponeurosis and peritoneum. The animals were divided into four subgroups of ten according to the day of death, scheduled in three, seven, 14 and 21 days...
July 2017: Revista do Colégio Brasileiro de Cirurgiões
Chandamany Arya, Camila A Saez Cabesas, Hubert Huang, Srinivasa R Raghavan
Colloidal particles can be induced to cluster by adding polymers in a process called bridging flocculation. For bridging to occur, the polymer must bind strongly to the surfaces of adjacent particles, such as via electrostatic interactions. Here, we introduce a new system where bridging occurs due to specific interactions between the side chains of an amphiphilic polymer and supramolecules on the particle surface. The polymer is a hydrophobically modified chitosan (hmC) while the particles are uniform polymeric microbeads (∼160 μm in diameter) made by a microfluidic technique and functionalized on their surface by α-cyclodextrins (CDs)...
October 10, 2017: ACS Applied Materials & Interfaces
Denicar Lina Nascimento Fabris Maeda, Milene Tavares Batista, Lennon Ramos Pereira, Mariana de Jesus Cintra, Jaime Henrique Amorim, Camila Mathias-Santos, Sara Araújo Pereira, Silvia Beatriz Boscardin, Sandriana Dos Ramos Silva, Eliana L Faquim-Mauro, Vanessa Barbosa Silveira, Danielle Bruna Leal Oliveira, Stephen Albert Johnston, Luís Carlos de Souza Ferreira, Juliana Falcão Rodrigues
The heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli display adjuvant effects to coadministered antigens, leading to enhanced production of serum antibodies. Despite extensive knowledge of the adjuvant properties of LT derivatives, including in vitro-generated non-toxic mutant forms, little is known about the capacity of these adjuvants to modulate the epitope specificity of antibodies directed against antigens. This study characterizes the role of LT and its non-toxic B subunit (LTB) in the modulation of antibody responses to a coadministered antigen, the dengue virus (DENV) envelope glycoprotein domain III (EDIII), which binds to surface receptors and mediates virus entry into host cells...
2017: Frontiers in Immunology
Camila L Madeira, Jim A Field, Michael T Simonich, Robert L Tanguay, Jon Chorover, Reyes Sierra-Alvarez
The insensitive munitions compound 3-nitro-1,2,4-triazol-5-one (NTO) was recently approved by the U.S. Army to replace cyclotrimethylene trinitramine (RDX) in conventional explosives. As its use becomes widespread, concern about the potential toxicity of NTO increases. NTO can undergo microbial reduction to 3-amino-1,2,4-triazol-5-one (ATO), which is recalcitrant in waterlogged soils. In this study, the acute toxicity of NTO and ATO towards various organisms, including microorganisms (i.e., methanogenic archaea, aerobic heterotrophs, and Aliivibrio fischeri (Microtox assay)), the microcrustacean Daphnia magna (ATO only), and zebrafish embryos (Danio rerio), was assessed...
September 28, 2017: Journal of Hazardous Materials
Roberto Olivares, Pamela Vidal, Camila Sotomayor, Mackarenna Norambuena, Mario Luppi, Francisco Silva, Marcela Cifuentes
INTRODUCTION: Brucellosis is a zoonosis caused by Brucella spp. It may be acquired by consuming unpasteurized dairy products. Brucellosis has a low incidence in Chile, thus, we have a scarce data. AIM: To report and to characterize the first series of clinical cases of adult patients diagnosed with brucellosis in Chile. METHODS: We describe a series of 13 clinical cases in patients diagnosed between 2000 and 2016 in three different centers in the Metropolitan Region, Chile...
June 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Timóteo Matthies Rico, Karina Dos Santos Machado, Vanessa Pellegrini Fernandes, Samanta Winck Madruga, Patrícia Tuerlinckx Noguez, Camila Rose Guadalupe Barcelos, Mateus Madail Santin, Cristiane Rios Petrarca, Samuel Carvalho Dumith
Cancer treatment is an extremely stressful life experience that is accompanied by a range of psychological, social, physical, and practical difficulties. Cancer patients need to receive information that helps them to better understand the disease, assists them in decision-making, and helps them deal with treatment. Patients are interested in receiving such information. The degree of satisfaction with the information received has been associated with positive health outcomes, specifically regarding quality of life, severity of side effects, and psychological well-being...
October 9, 2017: Journal of Medical Systems
Marcelo Leiva-Bianchi, Felipe Cornejo, Andrés Fresno, Carolina Rojas, Camila Serrano
OBJECTIVE: This is the first time that the effectiveness of cognitive-behavioural therapy for post-disaster stress (CBT-PD) in symptoms of posttraumatic stress disorder (PTSD) has been tested outside the United States of America. DESIGN: Quasi-experiment with three groups. In the quasi-control group, complete CBT-PD was applied even though its members did not have PTSD; in quasi-experimental conditions, participants received complete treatment because they had this diagnosis; and in the third group, participants with PTSD received an abbreviated treatment (double sessions) due to organisational requirements...
October 5, 2017: Gaceta Sanitaria
Michele Aparecida Salvador, Camila Pinheiro Sousa, Simone Morais, Pedro de Lima-Neto, Adriana Nunes Correia, Paula Homem-de-Mello
Chlorhexidine (CHD), a germicidal drug, has degradation products that can be hemotoxic and carcinogenic. However, there is no consensus in literature about the degradation pathway. In order to shed light on that mechanism, we have employed Density Functional Theory to study reactants, in different protonation states, products and intermediates involved in the different pathways. Based on free energy values comparison and frontier molecular orbital analysis, we have obtained the most stable structures in each protonation state...
October 3, 2017: Computational Biology and Chemistry
Andrew W McPherson, Andrew Roth, Gavin Ha, Cedric Chauve, Adi Steif, Camila P E de Souza, Peter Eirew, Alexandre Bouchard-Côté, Sam Aparicio, S Cenk Sahinalp, Sohrab P Shah
No abstract text is available yet for this article.
October 6, 2017: Genome Biology
Ana Carolina Uchoa Vasconcelos, Felipe Martins Silveira, Ana Paula Neutzling Gomes, Sandra Beatriz Chaves Tarquinio, Ana Paula Veras Sobral, José Alcides Almeida de Arruda, Leorik Pereira da Silva, Marcia Maria Fonseca da Silveira, Larissa Ferreira Barbosa, Camila de Nazaré Alves de Oliveira Kato, Filipe Jaeger, Tarcília Aparecida da Silva, Ricardo Alves Mesquita
BACKGROUND: Odontogenic myxoma (OM) is an uncommon neoplasm of the jaws. Considering the importance of defining the relative incidence and demographic profile of these lesions in South America, the aim of this study was to analyze the clinical and imagiological features of OM from three South American oral pathology services and to discuss these findings in light of the literature. METHODS: Data regarding age, gender, anatomic site and imagiological features from 85 cases of OM were collected...
October 6, 2017: Journal of Oral Pathology & Medicine
Benedito Sergio Denadai, Camila Coelho Greco
No abstract is required.
October 5, 2017: Journal of Applied Physiology
Camila Morais Gonçalves da Silva, Michelle Franz-Montan, Cíntia Elisabeth Gomez Limia, Lígia Nunes de Morais Ribeiro, Mário Antônio Braga, Viviane Aparecida Guilherme, Camila Batista da Silva, Bruna Renata Casadei, Cíntia Maria Saia Cereda, Eneida de Paula
Ropivacaine is a local anesthetic with similar potency but lower systemic toxicity than bupivacaine, the most commonly used spinal anesthetic. The present study concerns the development of a combined drug delivery system for ropivacaine, comprised of two types of liposomes: donor multivesicular vesicles containing 250 mM (NH4)2SO4 plus the anesthetic, and acceptor large unilamellar vesicles with internal pH of 5.5. Both kinds of liposomes were composed of hydrogenated soy-phosphatidylcholine:cholesterol (2:1 mol%) and were prepared at pH 7...
2017: PloS One
Maria Manuela Estevinho, Joana Afonso, Isadora Rosa, Paula Lago, Eunice Trindade, Luís Correia, Cláudia Camila Dias, Fernando Magro
Background and Aims: Thiopurines are widely used in the management of inflammatory bowel diseases. However, their minimum effective dose and dose-response relationship remain undefined, and evidence about their use in clinical practice is mostly heterogeneous. This systematic review and meta-analysis aimed: i] to assess the clinical value of 6-thioguanine nucleotide thresholds; and ii] to compare mean 6-thioguanine nucleotide concentrations between patients in clinical remission vs. those with active disease...
June 30, 2017: Journal of Crohn's & Colitis
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