Brenda J Seymour, Brandon Trent, Brendan E Allen, Adam J Berlinberg, Jimmy Tangchittsumran, Widian K Jubair, Meagan E Chriswell, Sucai Liu, Alfredo Ornelas, Andrew Stahly, Erica E Alexeev, Alexander S Dowdell, Sunny L Sneed, Sabrina Fechtner, Jennifer M Kofonow, Charles E Robertson, Stephanie M Dillon, Cara C Wilson, Robert M Anthony, Daniel N Frank, Sean P Colgan, Kristine A Kuhn
Altered tryptophan catabolism has been identified in inflammatory diseases like rheumatoid arthritis (RA) and spondyloarthritis (SpA), but the causal mechanisms linking tryptophan metabolites to disease are unknown. Using the collagen-induced arthritis (CIA) model we identified alterations in tryptophan metabolism, and specifically indole, that correlated with disease. We demonstrated that both bacteria and dietary tryptophan were required for disease, and indole supplementation was sufficient to induce disease in their absence...
December 19, 2023: Journal of Clinical Investigation