keyword
MENU ▼
Read by QxMD icon Read
search

Immune suppression

keyword
https://www.readbyqxmd.com/read/29055189/a-mannose-specific-c-type-lectin-from-fenneropenaeus-merguiensis-exhibited-antimicrobial-activity-to-mediate-shrimp-innate-immunity
#1
Phanthipha Runsaeng, Peerapong Puengyam, Prapaporn Utarabhand
Being one type of pattern recognition receptors (PRRs), lectins exhibit a crucial role in the defense mechanism of invertebrates which are deficient in an adaptive immune system. A new C-type lectin called FmLC3 was isolated from hepatopancreas of Fenneropenaeus merguiensis by cloning approaches, RT-PCR and 5' and 3' RACE (rapid amplification of cDNA ends). A full-length cDNA of FmLC3 contains 607 bp with one open reading frame of 480bp, encoding a 159-amino acids peptide. The predicted primary structure of FmLC3 is composed of a signal peptide, a carbohydrate recognition domain with an EPN motif and one Ca(2+) binding site-2, including a double-loop region assisted by two conserved disulfide linkages...
October 18, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29055087/metabolism-and-tam-functions-it-takes-two-to-tango
#2
REVIEW
Massimiliano Mazzone, Alessio Menga, Alessandra Castegna
From the evidence on clinical studies and experimental mouse models we now know that tumor associated macrophages (TAMs) sustain tumor development in many different ways. They play a role in angiogenesis, tumor cell invasion and metastasis formation. Additionally, TAMs interfere with natural killer and T cell antitumoral activities, producing an immune suppressive environment that protects tumor cell growth. This indicates that the tumoricidal activity of macrophages within the tumor microenviroment is lost due to an imbalance of the regulatory mechanisms underpinning these cells' function...
October 21, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29055004/stat4-regulates-the-cd8-regulatory-t-cell-t-follicular-helper-cell-axis-and-promotes-atherogenesis-in-insulin-resistant-ldlr-mice
#3
Parésa L Taghavie-Moghadam, Tayab C Waseem, Julian Hattler, Lindsey M Glenn, Anca D Dobrian, Mark H Kaplan, Yi Yang, Roza Nurieva, Jerry L Nadler, Elena V Galkina
The metabolic syndrome and diabetic conditions support atherosclerosis, but the exact mechanisms for accelerated atherogenesis remain unclear. Although the proinflammatory role of STAT4 in atherosclerosis and diet-induced insulin resistance (IR) was recently established, the impact of STAT4 on atherogenesis in conditions of IR is not known. In this study, we generated Stat4(-/-)Ldlr(-/-) mice that were fed a diabetogenic diet with added cholesterol (DDC). DDC-fed Stat4(-/-)Ldlr(-/-) mice demonstrated improved glucose tolerance, insulin sensitivity, and a 36% reduction in atherosclerosis compared with Ldlr(-/-) controls...
October 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29054723/aberrant-frequency-of-il-35-producing-b-cells-in-colorectal-cancer-patients
#4
Ke Wang, Hui Gong, Rui Chai, Hang Yuan, Yanxia Chen, Jinlin Liu
BACKGROUND: The IL-10 dependent regulatory function of B cells had recently more and more investigated and play important roles in cancer immunity, however, beyond IL-10 whether other inhibitory cytokines play an important role in cancer is lacking. Here, we investigated the role of IL-35 producing B cells in colorectal cancer (CRC). METHODS: Thirty-two healthy controls (HC) and 49 untreated CRC patients were enrolled and the IL-35 producing B cells in the peripheral blood were investigated...
October 17, 2017: Cytokine
https://www.readbyqxmd.com/read/29054595/the-n-acylethanolamine-acid-amidase-inhibitor-arn077-suppresses-inflammation-and-pruritus-in-a-mouse-model-of-allergic-dermatitis
#5
O Sasso, M Summa, A Armirotti, S Pontis, C De Mei, D Piomelli
N-acylethanolamine acid amidase (NAAA), a cysteine hydrolase highly expressed in macrophages and B-lymphocytes, catalyzes the degradation of palmitoylethanolamide (PEA). PEA is an agonist of peroxisome proliferator-activated receptor-α (PPAR-α) and an important regulator of pain and innate immunity. In the present study, we investigated the properties of the NAAA inhibitor, ARN077, in a mouse model of allergic contact dermatitis. Acute topical applications of ARN077 attenuated key signs of DNFB-induced dermatitis in a dose-dependent manner...
October 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29054459/lymphocyte-subset-analysis-in-quantiferon-tb-gold-plus-and-t-spot-tb-for-latent-tuberculosis-infection-in-rheumatoid-arthritis
#6
Hidetoshi Igari, Satoru Ishikawa, Takuya Nakazawa, Yoshihiro Oya, Hidekazu Futami, Mizue Tsuyuzaki, Kiminori Suzuki, Ryutaro Matsumura
Rheumatoid arthritis (RA) is an immune mediated inflammatory disorder, and immune suppressive drugs are prescribed. RA patients receiving treatments are in a kind of immunosuppressive condition that presents increased risk of developing active tuberculosis. Accurate diagnosis of latent tuberculosis infection (LTBI) is recommended for RA. QuantiFERON(®)-TB Gold Plus (QFT-Plus), a novel IGRA, has two tubes (TB1 and TB2). TB2 is designed to elicit both CD4 and CD8 T-cell responses, with expected increased sensitivity...
October 18, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29054343/aster-yomena-extract-ameliorates-pro-inflammatory-immune-response-by-suppressing-nf-%C3%AE%C2%BAb-activation-in-raw-264-7-cells
#7
Kyung-A Hwang, Yu-Jin Hwang, Jin Song
BACKGROUND: Aster yomena, an edible vegetable, is a perennial herb found in Korea, China, Japan, and Siberia. It is used as folk medicine to treat cough, bronchial asthma, and insect bites. A. yomena was recently shown to have antioxidant and anti-asthmatic activities. Studies have not yet evaluated the anti-inflammatory effects of the various solvent fractions of A. yomena. We investigated the anti-inflammatory activity of various solvent fractions (hexane, dichloromethane, ethyl acetate, and butanol) from ethanol extract of A...
October 18, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29054272/insights-on-the-hla-binding-peptidome-in-cancer
#8
Douglas F Lake
The intracellular compartments for proteolytic antigen processing in tumor cells produce peptides that are presented by MHC molecules to T cells. But first, the ubiquitin ligase system tags defective, misfolded, aged, and unstable proteins for degradation through the proteasome. Ubiqitinated proteins are unfolded and fed into the barrel-shaped core of the proteasome where a collection of multiple different proteases cleave proteins into oligopeptides. After exiting the proteasome, these oligopeptides are either completely degraded into amino acids or trimmed at the N- and C-termini so that they bind to transporter associated with antigen processing (TAP)...
2017: Enzymes
https://www.readbyqxmd.com/read/29053971/a-gut-microbial-mimic-that-hijacks-diabetogenic-autoreactivity-to-suppress-colitis
#9
Roopa Hebbandi Nanjundappa, Francesca Ronchi, Jinguo Wang, Xavier Clemente-Casares, Jun Yamanouchi, Channakeshava Sokke Umeshappa, Yang Yang, Jesús Blanco, Helena Bassolas-Molina, Azucena Salas, Hamza Khan, Robyn M Slattery, Madeleine Wyss, Catherine Mooser, Andrew J Macpherson, Laura K Sycuro, Pau Serra, Derek M McKay, Kathy D McCoy, Pere Santamaria
The gut microbiota contributes to the development of normal immunity but, when dysregulated, can promote autoimmunity through various non-antigen-specific effects on pathogenic and regulatory lymphocytes. Here, we show that an integrase expressed by several species of the gut microbial genus Bacteroides encodes a low-avidity mimotope of the pancreatic β cell autoantigen islet-specific glucose-6-phosphatase-catalytic-subunit-related protein (IGRP206-214). Studies in germ-free mice monocolonized with integrase-competent, integrase-deficient, and integrase-transgenic Bacteroides demonstrate that the microbial epitope promotes the recruitment of diabetogenic CD8+ T cells to the gut...
October 19, 2017: Cell
https://www.readbyqxmd.com/read/29053937/studies-with-herpes-zoster-vaccines-in-immune-compromised-patients
#10
Myron J Levin, Eddy Bresnitz, Zoran Popmihajlov, Adriana Weinberg, Kai-Li Liaw, English Willis, Jeffrey R Curtis
INTRODUCTION: The active component of the herpes zoster vaccine (ZVL), recommended for people ≥50 years of age, is a live attenuated varicella-zoster virus. ZVL is contraindicated for immune compromised individuals, with limited regard to the degree of immunosuppression. Areas covered: This review evaluates phase I and II, and observational studies for ZVL and published reports of the off-label use of ZVL, for conditions and therapies for which investigators considered the risk-benefit for using ZVL to be favorable...
October 20, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29053856/propolis-supplementation-attenuates-the-negative-effects-of-oxidative-stress-induced-by-paraquat-injection-on-productive-performance-and-immune-function-in-turkey-poults
#11
Ahmed O Abass, Nancy N Kamel, Walaa H Khalifa, G F Gouda, M A F El-Manylawi, Gamal M K Mehaisen, Magdi M Mashaly
Paraquat (PQ) is used as a herbicide in agriculture and causes oxidative and inflammatory damage to animal tissues. The current study was conducted to investigate the positive effects of dietary propolis (PR), as a potent naturally produced antioxidant, on growth performance and immune function of turkey poults exposed to oxidative stress induced by PQ injection. Native male turkey poults (n = 120, 49-d-old) were randomly assigned into 4 groups: poults received a basal diet with a daily subcutaneous PQ injection of 5 mg/kg BW for 7 consecutive days (PQ group), an experimental diet containing 1 g/kg PR with a daily subcutaneous PQ injection for 7 days (PR+PQ group), or received the experimental PR diet with a daily subcutaneous injection of 0...
October 5, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053414/perk-phosphorylated-eif2%C3%AE-pathway-suppresses-tumor-metastasis-through-downregulating-expression-of-programmed-death-ligand-1-and-cxcl5-in-triple-negative-breast-cancer
#12
Weiwei Zou, Yu Bai, Xilong Wang, Kai Cheng, Hongguang Sun, Guoqiang Zhang, Xiaohong Wang, Zhenlin Yang
Endoplasmic reticulum (ER) stress has been reported to be associated with metastasis in many malignant tumors. PKR-like ER kinase-phosphorylated eukaryotic translation initiation factor 2α (PERK-p-eIF2α) pathway is one of the three main signal pathways in ER stress, however, its mechanism in regulating breast cancer (BC) relapse or metastasis was still not completely understood. Besides, drug resistance was an important factor influencing the effect of tumor treatment and whether PERK-p-eIF2α pathway was involved in the drug resistance to BC treatment also needs to be explored...
October 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29052304/immunotherapy-for-hepatitis-b-in-the-direct-acting-anti-viral-era-reevaluating-the-thymosin-%C3%AE-1-efficacy-trials-in-light-of-a-combination-therapy-approach
#13
Paul H Naylor, Milton G Mutchnick
Hepatitis B virus (HBV) causes both acute and chronic hepatitis and infects large numbers of individuals worldwide. Unfortunately, prediction of typical clinical outcome is problematic and there is considerable variability in the frequency, duration and severity of disease progression. The mainstay of HBV treatment is directed towards the suppression of HBV replication by nucleos(t)ide analogs (NUCs). The use of immunomodulators such as α-Interferon and thymosin α1 can, in select patients, result in elimination of both HBsAg and HBeAg...
October 20, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29052136/human-t-cell-leukemia-virus-type-1-infection-and-adult-t-cell-leukemia
#14
Chi-Ping Chan, Kin-Hang Kok, Dong-Yan Jin
Human T-cell leukemia virus type 1 (HTLV-1) is the first retrovirus discovered to cause adult T-cell leukemia (ATL), a highly aggressive blood cancer. HTLV-1 research in the past 35 years has been most revealing in the mechanisms of viral oncogenesis. HTLV-1 establishes a lifelong persistent infection in CD4(+) T lymphocytes. The infection outcome is governed by host immunity. ATL develops in 2-5% of infected individuals 30-50 years after initial exposure. HTLV-1 encodes two oncoproteins Tax and HBZ, which are required for initiation of cellular transformation and maintenance of cell proliferation, respectively...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29052088/fascin-1-contributes-to-neuropathic-pain-by-promoting-inflammation-in-rat-spinal-cord
#15
Binbin Wang, Bingbing Fan, Qijun Dai, Xingguo Xu, Peipei Jiang, Lin Zhu, Haifeng Dai, Zhigang Yao, Zhongling Xu, Xiaojuan Liu
Neuropathic pain is a complicated clinical syndrome caused by heterogeneous etiology. Despite the fact that the underlying mechanisms remain elusive, it is well accepted that neuroinflammation plays a critical role in the development of neuropathic pain. Fascin-1, an actin-bundling protein, has been proved to be involved in the processing of diverse biological events including cellular development, immunity, and tumor invasion etc. Recent studies have shown that Fascin-1 participates in antigen presentation and the regulation of pro-inflammatory agents...
October 19, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29052054/suppression-of-the-toll-like-receptor-7-dependent-type-i-interferon-production-pathway-by-autophagy-resulting-from-enterovirus-71-and-coxsackievirus-a16-infections-facilitates-their-replication
#16
Jie Song, Yajie Hu, Jiaqi Li, Huiwen Zheng, Jingjing Wang, Lei Guo, Haijng Shi, Longding Liu
Toll-like receptors (TLRs) act as molecular sentinels, detecting invading viral pathogens and triggering host innate immune responses, including autophagy. However, many viruses have evolved a series of strategies to manipulate autophagy for their own benefit. Enterovirus 71 (EV71) and coxsackievirus A16 (CA16), as the primary agents causing hand, foot and mouth disease (HFMD), can induce autophagy leading to their replication. Therefore, the objective of this study was to investigate whether enhanced viral replication caused by autophagy in EV71 and CA16 infections was associated with a TLR-related signaling pathway...
October 19, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29051763/il-12p35-inhibits-neuroinflammation-and-ameliorates-autoimmune-encephalomyelitis
#17
Jin Kyeong Choi, Ivy M Dambuza, Chang He, Cheng-Rong Yu, Anita N Uche, Mary J Mattapallil, Rachel R Caspi, Charles E Egwuagu
Multiple sclerosis (MS) is an inflammatory demyelinating disease in which cytokines produced by immune cells that infiltrate the brain and spinal cord play a central role. We show here that the IL-12p35, the alpha subunit of IL-12 or IL-35 cytokine, might be an effective biologic for suppressing neuroinflammatory responses and ameliorating the pathology of experimental autoimmune encephalomyelitis (EAE), the mouse model of human MS. We further show that IL-12p35 conferred protection from neuropathy by inhibiting the expansion of pathogenic Th17 and Th1 cells and inhibiting trafficking of inflammatory cells into the brain and spinal cord...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29051270/hypoxia-induced-pd-l1-pd-1-crosstalk-impairs-t-cell-function-in-sleep-apnoea
#18
Carolina Cubillos-Zapata, Jose Avendaño-Ortiz, Enrique Hernandez-Jimenez, Victor Toledano, Jose Casas-Martin, Anibal Varela-Serrano, Marta Torres, Isaac Almendros, Raquel Casitas, Isabel Fernández-Navarro, Aldara Garcia-Sanchez, Luis A Aguirre, Ramón Farre, Eduardo López-Collazo, Francisco García-Rio
Obstructive sleep apnoea (OSA) is associated with higher cancer incidence, tumour aggressiveness and cancer mortality, as well as greater severity of infections, which have been attributed to an immune deregulation. We studied the expression of programmed cell death (PD)-1 receptor and its ligand (PD-L1) on immune cells from patients with OSA, and its consequences on immune-suppressing activity. We report that PD-L1 was overexpressed on monocytes and PD-1 was overexpressed on CD8(+) T-cells in a severity-dependent manner...
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29051224/advanced-glycation-end-products-impair-nlrp3-inflammasome-mediated-innate-immune-responses-in-macrophages
#19
Seunghwan Son, Inhwa Hwang, Seung Hyeok Han, Jeon-Soo Shin, Ok Sarah Shin, Je-Wook Yu
Advanced glycation end products (AGEs) are adducts formed on proteins by glycation with reducing sugars, such as glucose, and tend to form and accumulate under hyperglycemic conditions. AGE accumulation alters protein function and has been implicated in the pathogenesis of many degenerative diseases such as diabetic complications. AGEs have also been shown to promote the production of pro-inflammatory cytokines, but the roles of AGEs in inflammasome signaling have not been explored in detail. Here, we present evidence that AGEs attenuate activation of the NLRP3 inflammasome in bone marrow-derived macrophages (BMDMs) as determined by caspase-1 processing and interleukin-1β production...
October 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29051064/harnessing-the-cross-talk-between-tumor-cells-and-tumor-associated-macrophages-with-a-nano-drug-for-modulation-of-glioblastoma-immune-microenvironment
#20
Tong-Fei Li, Ke Li, Chao Wang, Xin Liu, Yu Wen, Yong-Hong Xu, Quan Zhang, Qiu-Ya Zhao, Ming Shao, Yan-Ze Li, Min Han, Naoki Komatsu, Li Zhao, Xiao Chen
Glioblastoma (GBM) is the most frequent and malignant brain tumor with a high mortality rate. The presence of a large population of macrophages (Mφ) in the tumor microenvironment is a prominent feature of GBM and these so-called tumor-associated Mφ (TAM) closely interact with the GBM cells to promote the survival, progression and therapy resistance of the GBM. Various therapeutic strategies have been devised either targeting the GBM cells or the TAM but few have addressed the cross-talks between the two cell populations...
October 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
keyword
keyword
43041
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"