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Hemangioendothelioma

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https://www.readbyqxmd.com/read/29757449/composite-hemangioendothelioma-settled-in-the-paraspinal-region-a-rare-case-report
#1
Sevki Gok, Mehmet Zafer Berkman, Eyup Baykara
Composite Hemangioendothelioma (CHE) is a very rare, low-grade malignant vascular tumor. It is most commonly seen as one or more nodules on both sides of the fingers and toes. This tumor is rarely settled in the paraspinal muscles. The age of onset is usually between the ages of 21 and 72 (1), with average age of 39.5-41 years. The treatment is gross total removal of the lesion. The definitive diagnosis is made histopathologically. Our case was a 54-year-old male patient. He had a complaint of low back pain...
April 24, 2018: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29737108/-clinical-and-ultrasonographic-features-of-hepatic-infantile-hemangioendothelioma
#2
Hong Wang, Huan Zhang, Ting-Ting Qiu, Yu-Lan Peng
OBJECTIVE: To investigate the clinical manifestations and ultrasound features of hepatic infantile hemangioendothelioma (IHE). METHODS: This study retrospectively analyzed the clinical features and ultrasound characteristics of 8 patients of IHE,whose diagnosis was confirmed by surgery or liver biopsy from January 2010 to October 2016. RESULTS: Among the eight IHE patients,the male-to-female ratio was 1:1,with the mean age ranged from 15 d to 3 yr...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29697673/-solitary-epithelioid-hemangioendothelioma-concurrent-with-nodular-parenchymal-amyloidosis-of-the-lung-and-rosai-dorfman-disease
#3
O V Dolzhansky, E M Paltseva, M M Morozova, D V Bazarov, E V Boranov, D N Fedorov
The paper describes a case of solitary epithelioid hemangioendothelioma concurrent with nodular parenchymal AL amyloidosis of the lung and Rosai-Dorfman disease in a 70-year-old woman. The core of the tumor was represented by bone tissue with dendriform ossification, as well as by amyloid that showed green apple birefringence at polarized light microscopy. The peripheral portions of the tumor and the myxohyaline stroma exhibited slit-like structures, epithelioid and fusiform cells with small cytoplasmic vacuoles...
2018: Arkhiv Patologii
https://www.readbyqxmd.com/read/29697621/vascular-anomalies-from-a-clinicohistologic-to-a-genetic-framework
#4
Arin K Greene, Jeremy A Goss
BACKGROUND: Vascular anomalies currently are classified according to their clinical and histological characteristics. Recent advances in molecular genetics have enabled the identification of somatic mutations in most types of vascular anomalies. The purpose of this study was to collate information regarding the genetic basis of vascular anomalies. METHODS: The PubMed literature was reviewed for all citations that identified a mutation in a vascular anomaly between 1994 and 2017...
May 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29690962/effectiveness-of-vascular-markers-immunohistochemical-stains-in-soft-tissue-sarcomas
#5
Namra Naeem, Sajid Mushtaq, Noreen Akhter, Mudassar Hussain, Usman Hassan
OBJECTIVE: To ascertain the effectiveness of IHC markers of vascular origin like CD31, CD34, FLI1 and ERG in vascular soft tissue sarcomas including angiosarcomas, Kaposi sarcomas, epithelioid hemangioendothelioma and a non-vascular soft tissue sarcoma (Epithelioid sarcoma). STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, from 2011 to 2017. METHODOLOGY: Diagnosed cases of angiosarcomas (n=48), epithelioid hemangioendothelioma (n=9), Kaposi sarcoma (n=9) and epithelioid sarcoma (n=20) were selected...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29689240/diagnosing-epithelioid-hemangioendothelioma-with-pericardial-involvement
#6
Brianna E Balansay, Xinyuan Zhang, Patrick D Loftus, Joy Aparicio Valenzuela, Eduardo Zambrano, Anson M Lee
Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor that commonly affects lung, liver, and bone. Among all known EHE cases, only 20% have a pulmonary origin, with metastases to the pericardium occurring in less than 1% of these. Due to its low prevalence, variable presentation, and unknown latency period, a thoracic EHE diagnosis can be easily missed. This case outlines the unique pathologic features of EHE in a patient with cardiovascular disease, provides further insight into diagnosing a rare tumor, and provides a better understanding of the pathophysiology and progression of thoracic EHE...
April 21, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29622111/imaging-of-benign-neoplastic-and-nonneoplastic-salivary-gland-tumors
#7
REVIEW
Daniel Thomas Ginat
This article reviews the multimodality diagnostic imaging features of benign neoplastic and nonneoplastic tumors associated with the major salivary glands. Examples of neoplastic conditions that are depicted and discussed include pleomorphic adenoma, Warthin tumor, oncocytoma, peripheral nerve sheath tumors, lipoma, and hemangiomas or hemangioendotheliomas. Examples of nonneoplastic conditions that are depicted and discussed include ranulas, benign lymphoepithelial lesions, Kimura disease, and vascular malformations...
May 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29610165/a-case-report-of-2-sirolimus-related-deaths-among-infants-with-kaposiform-hemangioendotheliomas
#8
Hanru Ying, Congzhen Qiao, Xi Yang, Xiaoxi Lin
Kaposiform hemangioendothelioma (KHE) is a rare infiltrative vascular tumor that is potentially life-threatening when presenting with Kasabach-Merritt phenomenon (KMP). KMP is clinically characterized as severe thrombocytopenia and hypofibrinogenemia and therefore is associated with a high mortality rate. There is no standard of cure for KHE currently. Potential medications, including corticosteroids, propranolol, and chemotherapy drugs such as sirolimus, are often used for alleviating KHE symptoms. Although some case reports of sirolimus treatment have shown promising results with recovered coagulant parameters, the off-target effects may cause severe problems...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29610164/-pneumocystis-jirovecii-pneumonia-during-sirolimus-therapy-for-kaposiform-hemangioendothelioma
#9
Thomas B Russell, Emily K Rinker, Claire S Dillingham, Laurence B Givner, Thomas W McLean
Sirolimus is an effective therapy for children with kaposiform hemangioendothelioma with or without the Kasabach-Merritt phenomenon. We report the case of a child with kaposiform hemangioendothelioma and the Kasabach-Merritt phenomenon who developed Pneumocystis carinii pneumonia (PCP) while on sirolimus and a prednisolone taper, after lack of adequate response to prednisolone, propranolol, and vincristine. He had a prompt positive clinical and laboratory response to sirolimus, but 4 weeks after starting it, at the age of 4 months, he developed PCP...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29609064/massive-epitheloid-hemangioendothelioma-causing-non-cirrhotic-portal-hypertension
#10
Amir Taefi, Karen Matsukuma, Eric Chak
No abstract text is available yet for this article.
March 30, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29561329/vascular-tumors-in-infants-case-report-and-review-of-clinical-histopathologic-and-immunohistochemical-characteristics-of-infantile-hemangioma-pyogenic-granuloma-noninvoluting-congenital-hemangioma-tufted-angioma-and-kaposiform-hemangioendothelioma
#11
Emma F Johnson, Dawn M Davis, Megha M Tollefson, Karen Fritchie, Lawrence E Gibson
Vascular tumors in infants present a diagnostic and treatment dilemma for both clinicians and pathologists. Infantile hemangioma, the most common vascular tumor in infants, can be confused for other less common vascular tumors in infants. Correct and timely diagnosis is important, as some vascular tumors can be associated with life-threatening coagulopathy. We present the cases of 5 vascular tumors that have clinical and histologic overlap: infantile hemangioma, pyogenic granuloma, noninvoluting congenital hemangioma, tufted angioma, and kaposiform hemangioendothelioma...
April 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29554025/regional-differences-in-clinical-features-of-kaposiform-hemangioendothelioma-of-the-intestinal-tract
#12
Hironori Ohshita, Koya Kawase, Daisuke Takagi, Satoshi Kondo, Shinji Saitoh
No abstract text is available yet for this article.
March 16, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29546487/epithelioid-hemangioendothelioma-update-on-diagnosis-and-treatment
#13
REVIEW
Ari Rosenberg, Mark Agulnik
Epithelioid hemangioendothelioma (EHE) is an extremely rare sarcoma, as such it can pose a clinical dilemma based solely on its rarity. Also, the spectrum of disease varies greatly between an indolent disease and aggressive disease with widespread metastases. In our clinical practice, the primary focus has been to get a handle on the aggressive nature of the disease, which will then dictate how urgently one needs to treat the patient. Pathological review with immunohistochemistry and molecular characterization is paramount...
March 15, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29536769/clinical-and-imaging-features-of-kaposiform-hemangioendothelioma
#14
Pei-An Hu, Zheng-Rong Zhou
OBJECTIVE: Kaposiform hemangioendothelioma (KHE) is a unique locally aggressive vascular tumor with poor prognosis. The aim of this study is to assess the clinical and imaging features of KHE, and to compare the differences between solitary and diffusive infiltrative subtype further. METHODS: The clinical and radiological findings of a cohort of 25 cases with histologically proven KHE, between June 2011 and June 2016, were reviewed retrospectively. 7 solitary and 18 diffusive infiltrative subtypes KHE were included...
March 20, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29527734/fosb-immunoreactivity-in-endothelia-of-epithelioid-hemangioma-angiolymphoid-hyperplasia-with-eosinophilia
#15
Ana Ortins-Pina, Mar Llamas-Velasco, Sara Turpin, Luís Soares-de-Almeida, Paulo Filipe, Heinz Kutzner
BACKGROUND: Accurate distinction of epithelioid hemangioma (EH) from its malignant mimics is paramount but remains challenging due to its wide morphological spectrum and lack of objective molecular markers. FOSB oncogenic activation was recently identified as a key event in endothelial proliferation. We sought to investigate the FOSB staining pattern in EH with angiolymphoid hyperplasia with eosinophilia (EH-AHLE) morphology and to evaluate its value in differential diagnosis of epithelioid vascular tumors...
March 12, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29511030/telatinib-is-an-effective-targeted-therapy-for-pseudomyogenic-hemangioendothelioma
#16
David G P van IJzendoorn, Stefan Sleijfer, Hans Gelderblom, Ferry A L M Eskens, Geert J L H van Leenders, Karoly Szuhai, Judith V M G Bovée
Purpose: Pseudomyogenic hemangioendothelioma (PHE) is an extremely rare locally aggressive neoplasm with endothelial differentiation, which often presents with multiple lesions. These tumors have characteristic SERPINE1-FOSB fusions. We report a 17 years old patient with advanced unresectable PHE with a durable complete remission to the multi-tyrosine kinase inhibitor telatinib. The aim of this study was to generate an in vitro model for PHE, to study the functional consequences of SERPINE1-FOSB in endothelial cells, and its interaction with telatinib, to biologically substantiate the complete response to telatinib...
March 6, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29503064/giant-cervical-and-mediastinal-hemangioendothelioma-arising-from-subclavian-vein
#17
María José Moyano-Rodríguez, Florencio Quero-Valenzuela
No abstract text is available yet for this article.
March 1, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29476440/biopsy-is-not-necessary-for-the-diagnosis-of-soft-tissue-hemangiomas
#18
Eugenio Rimondi, Andreas F Mavrogenis, Costantino Errani, Teresa Calabrò, Alberto Bazzocchi, Giancarlo Facchini, Salvatore Donatiello, Paolo Spinnato, Daniel Vanel, Ugo Albisinni, Patrizia Pelotti
OBJECTIVE: To describe the clinical and ultrasonography (US) findings of soft tissue hemangiomas, and to compare with the results of histologic diagnosis after US-guided biopsy. METHOD AND MATERIALS: We retrospectively studied the files of 97 patients (48 female, 49 male; mean age, 34 years; range 4-84 years) with soft tissue hemangiomas diagnosed from 2004 to 2011. Mean follow-up was 9 years (range 7-13 years). Clinical presentation included intermittent mild pain associated with a soft tissue swelling/palpable mass in all patients, chronic pain and increased local heat in 29 patients, local swelling and decreased range of motion of the adjacent joint in 45 patients, and all the above symptoms in 23 patients...
February 23, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29453774/hobnail-retiform-dabska-hemangioendothelioma-located-in-the-jejunum
#19
LETTER
Yuxin Wang, Huan Han, Yiqi Du
No abstract text is available yet for this article.
February 17, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29415297/-hepatic-epithelioid-hemangioendothelioma-characteristic-signs-in-mri
#20
Fabian Ganss, Rainer Theurer, Niels Zorger
No abstract text is available yet for this article.
February 7, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
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