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https://www.readbyqxmd.com/read/27933606/relaxin-like-peptides-in-male-reproduction-a-human-perspective
#1
REVIEW
Richard Ivell, Alexander I Agoulnik, Ravinder Anand-Ivell
The relaxin family of peptide hormones and their cognate G-protein coupled receptors are becoming physiologically well characterized in the cardiovascular system and particularly in female reproductive processes. Much less is known about the physiology and pharmacology of these peptides in male reproduction, particularly as regards the human. H2-relaxin is involved in prostate function and growth, while INSL3 is a major product of the testicular Leydig cells and in the adult appears to modulate steroidogenesis and germ cell survival...
December 9, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27933451/association-between-adjuvant-chemotherapy-and-risk-of-acute-kidney-injury-in-elderly-women-diagnosed-with-early-stage-breast-cancer
#2
Shuling Li, Jiannong Liu, Beth A Virnig, Allan J Collins
PURPOSE: We studied elderly Medicare enrollees newly diagnosed with early-stage breast cancer to examine the association between adjuvant chemotherapy and acute kidney injury (AKI). METHODS: Using the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database, we conducted a retrospective cohort study including women diagnosed with stages I-III breast cancer at ages 66-89 years between 1992 and 2007. We performed one-to-one matching on time-dependent propensity score on the day of adjuvant chemotherapy initiation within 6 months after the first cancer-directed surgery based on the estimated probability of chemotherapy initiation at each day for each patient, using a Cox proportional hazards model...
December 8, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27933394/men-and-women-show-similar-survival-rates-after-breast-cancer
#3
Paulo Franscisco Mascarenhas Bender, Letícia Lima de Oliveira, Célia Regina Costa, Suzana Sales de Aguiar, Anke Bergmann, Luiz Claudio Santos Thuler
PURPOSE: To compare the disease-free survival (DFS) and overall survival (OS) rates of men and women undergoing treatment for breast cancer. METHODS: A retrospective cohort study of patients with breast cancer diagnosed and treated at the Cancer Hospital III of the National Cancer Institute of Brazil, Rio de Janeiro, Brazil, between 1999 and 2013. Male breast cancer cases were matched for age, year of diagnosis, and clinical staging to three female cases (1:3). Patient characteristics were abstracted from hospital records and medical charts...
December 8, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27933277/lectins-from-synadenium-carinatum-scll-and-artocarpus-heterophyllus-artinm-are-able-to-induce-beneficial-immunomodulatory-effects-in-a-murine-model-for-treatment-of-toxoplasma-gondii-infection
#4
Eliézer L P Ramos, Silas S Santana, Murilo V Silva, Fernanda M Santiago, Tiago W P Mineo, José R Mineo
Infection by Toxoplasma gondii affects around one-third of world population and the treatment for patients presenting toxoplasmosis clinically manifested disease is mainly based by a combination of sulfadiazine, pyrimethamine, and folinic acid. However, this therapeutic protocol is significantly toxic, causing relevant dose-related bone marrow damage. Thus, it is necessary to improve new approaches to investigate the usefulness of more effective and non-toxic agents for treatment of patients with toxoplasmosis...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27933160/post-sensitization-administration-of-non-digestible-oligosaccharides-and-bifidobacterium-breve-m-16v-reduces-allergic-symptoms-in-mice
#5
Betty C A M van Esch, Suzanne Abbring, Mara A P Diks, Gemma M Dingjan, Lucien F Harthoorn, A Paul Vos, Johan Garssen
To support dietary management of severe cow's milk allergic infants, a synbiotic mixture of non-digestible oligosaccharides and Bifidobacterium breve M-16V (B. breve) was designed from source materials that are completely cow's milk-free. It was investigated whether this specific synbiotic concept can reduce an established food allergic response in a research model for hen's egg allergy. Mice were orally sensitized once a week for 5 weeks to ovalbumin (OVA) using cholera toxin (CT) as an adjuvant. Non-sensitized mice received CT in PBS only...
June 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27932863/non-imidazole-based-histamine-h3-receptor-antagonists-with-anticonvulsant-activity-in-different-seizure-models-in-male-adult-rats
#6
Bassem Sadek, Ali Saad, Gniewomir Latacz, Kamil Kuder, Agnieszka Olejarz, Tadeusz Karcz, Holger Stark, Katarzyna Kieć-Kononowicz
A series of twelve novel non-imidazole-based ligands (3-14) was developed and evaluated for its in vitro binding properties at the human histamine H3 receptor (hH3R). The novel ligands were investigated for their in vivo protective effects in different seizure models in male adult rats. Among the H3R ligands (3-14) tested, ligand 14 showed significant and dose-dependent reduction in the duration of tonic hind limb extension in maximal electroshock (MES)-induced seizure model subsequent to acute systemic administration (5, 10, and 20 mg/kg, intraperitoneally), whereas ligands 4, 6, and 7 without appreciable protection in MES model were most promising in pentylenetetrazole (PTZ) model...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27932758/-expressions-of-her2-and-topo-ii%C3%AE-in-breast-cancer-and-%C3%A2-its-clinical-significance
#7
Ping Shuai
To detect the expressions of human epidermal growth factor receptor 2 (HER2) and Topo IIα in breast cancer, and to analyze the clinical significance of neoadjuvant chemotherapy for the anthracycline-based drugs.
 Methods: The HER2 and Topo IIα gene and protein expressions in cancer tissues from 189 patients with breast cancer were detected by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). And the objective response rate (ORR) and pathological complete rate (pCR) were analyzed...
November 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27932667/lymph-node-yield-is-an-independent-predictor-of-survival-in-rectal-cancer-regardless-of-receipt-of-neoadjuvant-therapy
#8
Zhaomin Xu, Mariana E Berho, Adan Z Becerra, Christopher T Aquina, Bradley J Hensley, Reza Arsalanizadeh, Katia Noyes, John R T Monson, Fergal J Fleming
AIMS: Lymph node yield (LNY) is used as a marker of adequate oncological resection. The American Joint Committee on Cancer (AJCC) currently recommends that at least 12 nodes are necessary to confirm node-negative disease for rectal cancer. A LNY of 12 is not always achieved, particularly in patients who have undergone neoadjuvant treatment. This study attempts to examine factors associated with LNY and its prognostic impact following neoadjuvant chemoradiation in rectal cancer. METHODS: The 2006-2011 National Cancer Data Base was queried for patients with clinical stage I-III rectal cancer who underwent a proctectomy...
December 8, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27932571/esmolol-before-cardioplegia-and-as-cardioplegia-adjuvant-reduces-cardiac-troponin-release-after-cardiac-surgery-a-randomized-trial
#9
Elena Bignami, Marcello Guarnieri, Annalisa Franco, Chiara Gerli, Monica De Luca, Fabrizio Monaco, Giovanni Landoni, Alberto Zangrillo
BACKGROUND: Cardioplegic solutions are the standard in myocardial protection during cardiac surgery, since they interrupt the electro-mechanical activity of the heart and protect it from ischemia during aortic cross-clamping. Nevertheless, myocardial damage has a strong clinical impact. We tested the hypothesis that the short-acting beta-blocker esmolol, given immediately before cardiopulmonary bypass and as a cardioplegia additive, would provide an extra protection to myocardial tissue during cardiopulmonary bypass by virtually reducing myocardial activity and, therefore, oxygen consumption to zero...
December 8, 2016: Perfusion
https://www.readbyqxmd.com/read/27932246/denaturing-action-of-adjuvant-affects-specificity-of-polyclonal-antibodies
#10
K V Barinova, E V Khomyakova, M L Kuravsky, E V Schmalhausen, V I Muronetz
Influence of the immunization procedure on the specificity of the produced antibodies towards different conformations of the antigen was investigated. It was demonstrated that intravenous immunization of a rabbit with an adjuvant-free solution of recombinant sperm-specific glyceraldehyde-3-phosphate dehydrogenase (dN-GAPDS) resulted in production of antibodies recognizing only native conformation of dN-GAPDS and exhibiting no cross-reaction with somatic isoenzyme of glyceraldehyde-3-phosphate dehydrogenase...
December 5, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27931837/an-update-on-the-multimodality-of-localized-rectal-cancer
#11
REVIEW
Mehmet Artac, Levent Korkmaz, Bassel El-Rayes, Philip A Philip
New strategies have reduced the local recurrence (LR) rate and extended the duration of overall survival (OS) in patients with localized rectal cancer (RC) in recent decades. The mainstay of curative treatment remains radical surgery; however, downsizing the tumor by neo-adjuvant chemo-radiotherapy and adjuvant cytotoxic therapy for systemic disease has shown significant additional benefit. The standardization of total mesorectal excision (TME), radiation treatment (RT) dose and fractionation, and optimal timing and sequencing of treatment modalities with the use of prolonged administration of fluoropyrimidine concurrent with RT have significantly decreased the rates of LR in locally advanced rectal cancer (LARC) patients...
December 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27931230/feasibility-and-efficacy-of-gemcitabine-and-docetaxel-combination-chemotherapy-for-bone-and-soft-tissue-sarcomas-multi-institutional-retrospective-analysis-of-134-patients
#12
Kazuhiro Tanaka, Susumu Joyama, Hirokazu Chuman, Hiroaki Hiraga, Hideo Morioka, Hideki Yoshikawa, Masami Hosaka, Mitsuru Takahashi, Tadahiko Kubo, Hiroshi Hatano, Mitsunori Kaya, Junya Toguchida, Yoshihiro Nishida, Akihito Nagano, Hiroshi Tsumura, Yukihide Iwamoto
BACKGROUND: Bone and soft tissue sarcomas (BSTS) are rare malignant tumors. Recently, the combination of gemcitabine and docetaxel (GD) was shown to have activity as second-line setting in BSTS. However, the efficacy as first-line and adjuvant settings and precise profiles of adverse events in Japanese patients are not known yet. In the present study, the feasibility and efficacy of GD in patients with BSTS were investigated. METHODS: Patients with BSTS treated with GD in our institutions were retrospectively analyzed...
December 8, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27931221/the-patterns-and-timing-of-recurrence-after-curative-resection-for-gastric-cancer-in-china
#13
Dan Liu, Ming Lu, Jian Li, Zuyao Yang, Qi Feng, Menglong Zhou, Zhen Zhang, Lin Shen
BACKGROUND: The recurrence of gastric cancer after curative resection had adverse effects on patients' survival. The treatment presence varied from different countries. The aims of this study were to understand the recurrence incidence, patterns, and timing and to explore the risk factors in China. METHODS: One thousand three hundred four patients who undergoing curative resection from more than 100 hospitals between January 1st 1986 and September 1st 2013, were surveyed in detail...
December 8, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27931134/constitutive-activation-of-alternative-nuclear-factor-kappa-b-pathway-in-canine-diffuse-large-b-cell-lymphoma-contributes-to-tumor-cell-survival-and-is-a-target-of-new-adjuvant-therapies
#14
Davis M Seelig, Daisuke Ito, Colleen L Forster, Una A Yoon, Matthew Breen, Linda J Burns, Veronika Bachanova, Kerstin Lindblad-Toh, Timothy D O'Brien, Stephen C Schmechel, Anthony E Rizzardi, Jaime F Modiano, Michael A Linden
Activation of the classical nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway is a common molecular event observed in both human and canine diffuse large B-cell lymphoma (DLBCL). Although the oncogenic potential of the alternative NFκB pathway (ANFκBP) has also been recently identified in DLBCL, its precise role in tumor pathogenesis and potential as a treatment target is understudied. We hypothesized that up-regulation of the ANFκBP plays an important role in the proliferation and survival of canine DLBCL cells, and we demonstrate that the ANFκBP is constitutively active in primary canine DLBCL samples and a cell line (CLBL1)...
December 8, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27930979/hp91-immunoadjuvant-an-hmgb1-derived-peptide-for-development-of-therapeutic-hpv-vaccines
#15
Somayeh Talebi, Azam Bolhassani, Seyed Mehdi Sadat, Rouhollah Vahabpour, Elnaz Agi, Sepideh Shahbazi
BACKGROUND: High percentage of human cervical malignancy is related to human papillomavirus (HPV) infections. Thus, it is important to find novel non-invasive treatment strategies among various therapeutic HPV vaccines. In current study, we investigated the protective and therapeutic effects of DNA- and protein-based vaccines using HPV16 E7 as a model antigen in tumor mice model. In this line, the full length of high-mobility group box 1 (HMGB1) protein as well as an HMGB1-derived short peptide (Hp91) was used as an adjuvant for stimulating adaptive immunity and developing the potency of these vaccines...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27930732/adjuvant-radiation-therapy-alone-for-hpv-related-oropharyngeal-cancers-with-high-risk-features
#16
William Su, Jerry Liu, Brett A Miles, Eric M Genden, Krzysztof J Misiukiewicz, Marshall Posner, Vishal Gupta, Richard L Bakst
BACKGROUND: Current standard of care for oropharyngeal cancers with positive surgical margins and/or extracapsular extension is adjuvant chemoradiotherapy. It is unknown whether HPV+ oropharyngeal cancer benefits from this treatment intensification. OBJECTIVE: To investigate the outcomes of HPV+ patients treated with adjuvant radiotherapy alone when chemoradiotherapy was indicated based on high risk pathological features. They were compared with high risk HPV+ patients treated with adjuvant chemoradiotherapy...
2016: PloS One
https://www.readbyqxmd.com/read/27930703/the-c-reactive-protein-to-albumin-ratio-as-a-predictor-of-severe-side-effects-of-adjuvant-chemotherapy-in-stage-iii-colorectal-cancer-patients
#17
Tetsuro Tominaga, Takashi Nonaka, Yorihisa Sumida, Shigekazu Hidaka, Terumitsu Sawai, Takeshi Nagayasu
BACKGROUND/AIMS: Adjuvant chemotherapy (AC) has been reported to improve the prognosis for patients with Stage III colorectal cancer (CRC). However, some patients experience severe side effects and must stop AC. The C-reactive protein (CRP) to albumin ratio (CAR) is a novel inflammation-based score that could reflect the patient's general condition. The aim of this study was to evaluate the predictive value of the CAR for side effects of AC in CRC. METHODS: A total of 136 CRC patients who received AC were retrospectively analyzed...
2016: PloS One
https://www.readbyqxmd.com/read/27930642/adjuvant-treatment-for-renal-cell-carcinoma-do-we-finally-have-a-major-breakthrough
#18
Devin N Patel, Robert A Figlin, Hyung L Kim
Clinical parameters can be used to identify patients at greatest risk for recurrence following nephrectomy for clinically localized renal cell carcinoma (RCC). Molecular tools are being developed to improve risk stratification. An increasing list of available treatments for metastatic RCC continues to provide hope that an effective adjuvant therapy will be identified for patients with high-risk, clinically localized disease. In a phase 3 adjuvant therapy trial (S-TRAC), sunitinib increased median disease-free survival in patients with clear cell RCC who were at very high risk...
November 2016: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/27930628/should-we-consider-adjuvant-therapy-for-rectal-cancer-after-neoadjuvant-chemoradiotherapy
#19
Al B Benson
No abstract text is available yet for this article.
October 2016: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/27930570/successful-treatment-of-a-rare-extended-retroperitoneal-necrotizing-soft-tissue-infection-caused-by-extended-spectrum-beta-lactamase-producing-escherichia-coli-a-case-report
#20
Rui He, Xin Qi, Bing Wen, XiangYan Li, Li Guo
RATIONALE: Retroperitoneal necrotizing soft tissue infection (NSTI) is a rare but life-threatening disease. Here, we present a case of extended retroperitoneal NSTI caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E coli). PATIENT CONCERNS: The patient complained of progressive redness, swelling, and right flank pain for 10 days, extending to the scrotum for 1 day. DIAGNOSES: He was admitted with an initial diagnosis of cellulitis...
December 2016: Medicine (Baltimore)
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