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Epithelioid Hemangioendothelioma

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https://www.readbyqxmd.com/read/28031827/pemetrexed-for-epithelioid-haemangioendothelioma-of-the-pleura
#1
Shingo Kanemura, Kozo Kuribayashi, Yumiko Moriya, Shigeki Shimizu, Tohru Tsujimura, Takashi Nakano
A 31-year-old woman presented with a 2-month history of dull left back pain. Chest roentgenography revealed pleural thickening in the left lung apex, whereas chest computed tomography showed a left pleural effusion with diffuse pleural thickening. Based on these findings, malignant mesothelioma was suspected. Video-assisted thoracoscopic pleural biopsy was performed, and subsequent staining of the specimen revealed negative results for anti-cytokeratin antibodies and positive results for vascular endothelial immunohistochemical markers...
November 2016: Respirology Case Reports
https://www.readbyqxmd.com/read/28031549/clinicopathological-features-and-prognosis-of-hepatic-epithelioid-hemangioendothelioma-after-liver-resection-and-transplantation
#2
Dong-Hwan Jung, Shin Hwang, Seung-Mo Hong, Ki-Hun Kim, Young-Joo Lee, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Gil-Chun Park, Eunsil Yu, Sung-Gyu Lee
BACKGROUND Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor. We present a single-center study on hepatic EHE cases treated by hepatic resection (HR) or liver transplantation (LT). MATERIAL AND METHODS Six HR patients with hepatic EHE were identified during 5 years from 2010 to 2014; EHE represented 0.13% (6 of 4572) of all primary liver tumors. Two LT recipients were also identified during 12 years from 2003 to 2014, who represented 0.06% (2 of 3576) of all adult LT patients. RESULTS Mean age of the patients was 42...
December 29, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28012782/epithelioid-hemangioendothelioma-presenting-as-inferior-vena-cava-obstruction-diagnosed-using-an-endovascular-thrombectomy-device
#3
Loay Kabbani, Praveen Balraj, Jeff Mathews, Francis Tinney, Scott Schwartz, David Kwon, Felix Braun, Sara Wasilenko
Epithelioid hemangioendothelioma is a rare vascular sarcoma that arises from the lining (intima) of blood vessels. We report a case of epithelioid hemangioendothelioma in a 43-year-old male patient, who presented with inferior vena cava obstruction and acute bilateral lower extremity deep vein thrombosis. Mechanical thrombectomy was performed with an endovascular thrombectomy device, followed by stent placement in the inferior vena cava. The initial pathology on the retrieved specimen revealed an undifferentiated neoplasm, and surgical resection of the retroperitoneal soft tissue tumor of the inferior vena cava documented a rare case of epithelioid hemangioendothelioma...
December 21, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28009608/fosb-is-a-useful-diagnostic-marker-for-pseudomyogenic-hemangioendothelioma
#4
Yin P Hung, Christopher D M Fletcher, Jason L Hornick
Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma is a distinctive vascular neoplasm of intermediate biological potential with a predilection for young adults and frequent multifocal presentation. Pseudomyogenic hemangioendothelioma is characterized by loose fascicles of plump spindled and epithelioid cells with abundant eosinophilic cytoplasm and coexpression of keratins and endothelial markers. Recently, a SERPINE1-FOSB fusion has been identified as a consistent genetic alteration in pseudomyogenic hemangioendothelioma...
December 22, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27895527/phase-ii-trial-of-angiotensin-1-7-for-the-treatment-of-patients-with-metastatic-sarcoma
#5
Paul D Savage, James Lovato, K Bridget Brosnihan, Antonius A Miller, W Jeffrey Petty
Background. Angiotensin-(1-7) [Ang-(1-7)] is an endogenous antiangiogenic hormone with anticancer activity. In a phase I study of Ang-(1-7), two of three patients with metastatic sarcoma experienced disease stabilization. This phase II study examined clinical and biomarker outcomes for patients with metastatic sarcoma. Methods. Ang-(1-7) was administered by subcutaneous injection at a dose of 20 mg daily. If excessive toxicities occurred in the first cohort, a dose deescalation cohort was allowed. Blood samples were obtained to measure changes in biomarkers...
2016: Sarcoma
https://www.readbyqxmd.com/read/27895413/hepatic-epithelioid-hemangioendothelioma-dilemma-and-challenges-in-the-preoperative-diagnosis
#6
Hai-Jie Hu, Yan-Wen Jin, Qiu-Yang Jing, Anuj Shrestha, Nan-Sheng Cheng, Fu-Yu Li
Hepatic epithelioid hemangioendothelioma (HEHE) is a rare category of vascular tumor with uncertain malignant potential. It commonly presents nonspecific and variable clinical manifestations, ranging from asymptomatic to hepatic failure. In addition, laboratory measurements and imaging features also lack specificity in the diagnosis of HEHE. The aim of the present study is to highlight the dilemma and challenges in the preoperative diagnosis of HEHE, and to enhance awareness of the range of hepatobiliary surgery available in patients with multiple hepatic nodular lesions on imaging...
November 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27878449/pseudomyogenic-hemangioendothelioma-a-vascular-tumor-previously-undescribed-in-the-oral-cavity
#7
Yeshwant B Rawal, Kenneth M Anderson, Thomas B Dodson
The pseudomyogenic hemangioendothelioma (PMH) is a low-grade malignant vascular neoplasm of different tissue planes including skin and soft tissue. Primary tumors in the skeletal muscle and bone have also been diagnosed. The PMH was introduced into the WHO classification of tumors of soft tissue and bone in 2013. This is the first description of oral involvement. A 21-year-old female presented with a 2-month old swelling of her gingiva. The swelling appeared red in color and was soft in consistency. A clinical diagnosis of a pyogenic granuloma was made and an incisional biopsy was submitted for histopathological evaluation...
November 22, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27818541/hepatic-epithelioid-hemangioendothelioma-a-report-from-three-university-centers
#8
Antonello Giardino, Frank H Miller, Bobby Kalb, Miguel Ramalho, Diego R Martin, Karina Rodacki, John T Woosley, Richard C Semelka
OBJECTIVE: To determine common imaging findings of hepatic epithelioid hemangioendothelioma on magnetic resonance images. MATERIALS AND METHODS: A search was made of three institutional databases between January 2000 and August 2012. Seven patients (mean age, 47 years; range, 21-66 years; 6 women) with pathology-confirmed diagnosis of hepatic epithelioid hemangioendothelioma who had undergone magnetic resonance imaging were identified. None of the patients had received any treatment for hepatic epithelioid hemangioendothelioma at the time of the initial magnetic resonance imaging examination...
September 2016: Radiologia Brasileira
https://www.readbyqxmd.com/read/27684838/uncommon-liver-tumors-case-report-and-literature-review
#9
Chia-Hung Wu, Nai-Chi Chiu, Yi-Chen Yeh, Yu Kuo, Sz-Shian Yu, Ching-Yao Weng, Chien-An Liu, Yi-Hong Chou, Yi-You Chiou
BACKGROUND: Beside hepatocellular carcinoma, metastasis, and cholangiocarcinoma, the imaging findings of other relatively uncommon hepatic lesions are less discussed in the literature. Imaging diagnosis of these lesions is a daily challenge. In this article, we review the imaging characteristics of these neoplasms. METHODS: From January 2003 to December 2014, 4746 patients underwent liver biopsy or hepatic surgical resection in our hospital. We reviewed the pathological database retrospectively...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27676560/p2-24-pulmonary-epithelioid-hemangioendothelioma-a-case-report%C3%A2-of-spontaneous-regression-track-supportive-care-and-others
#10
Raquel Rojas-Vigott, Cinthya Monge Castro, Steffi Romero Méndez
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27646891/-pulmonary-epithelioid-hemangioendothelioma-a-clinicopathologic-analysis-of-six-cases
#11
Z Y Ding, R S Zhang, B Yu, X T Wang, Z F Lu, Q L Shi, X J Zhou, Q Shen
Objective: To investigate the clinicopathologic characteristics, differential diagnosis and prognosis of pulmonary epithelioid hemangioendotheliomas (PEHs). Methods: The clinical symptoms and imaging findings of 6 cases of PEHs were investigated and pathologic analyses including histomorphologic and immunohistochemical studies were performed. Results: Clinical symptoms of the patients were nonspecific and insidious. The typical radiological manifestation was characterized by multiple small pulmonary nodules...
September 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27607156/primary-left-tibial-epithelioid-hemangioendotheliomas-with-multiple-metastases-revealed-by-fdg-pet-ct-imaging
#12
Haimin Zhao, Jiankui Han, Lei Qin, Changming Zhang
Bone epithelioid angiosarcoma is an extremely rare osseous malignancy with an aggressive and destructive biological behavior. We present FDG PET/CT findings of a 59-year-old woman with left lower limb pain for 1 month. The images revealed abnormal activity in both left fibula and left tibia. In addition, abnormal activity in the sacrum and enlarged retroperitoneal lymph nodes was also noted. Pathological examination demonstrated bone epithelioid angiosarcoma.
November 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27594996/long-term-follow-up-after-resection-emphasizes-the-role-of-surgery-in-primary-hepatic-epithelioid-hemangioendothelioma
#13
Arianeb Mehrabi, Katrin Hoffmann, Karl Heinz Weiss, Carolin Mogler, Peter Schemmer, Markus W Büchler, Ingo Alldinger
BACKGROUND: Primary Hepatic Epithelioid Hemangioendothelioma is an extremely rare tumor of vascular origin. PATIENTS: In this work we present clinical data and long term results of eight patients who were surgically treated in our institution. Liver transplantation was performed in five patients (four cadaveric and one living related) and major liver resection in three patients. Three patients are alive with recurrent tumor. After a median follow-up of 100 months (48-266) all patients are alive...
November 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27551853/epithelioid-hemangioendothelioma-of-tongue-presenting-as-a-papilloangioma-in-a-pregnant-woman
#14
Mainak Dutta, Kuntal Roy
No abstract text is available yet for this article.
August 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27515856/diagnostic-utility-of-fosb-immunohistochemistry-in-pseudomyogenic-hemangioendothelioma-and-its-histological-mimics
#15
Shintaro Sugita, Hiroshi Hirano, Noriaki Kikuchi, Terufumi Kubo, Hiroko Asanuma, Tomoyuki Aoyama, Makoto Emori, Tadashi Hasegawa
BACKGROUND: Pseudomyogenic hemangioendothelioma (PHE) is an unusual vascular tumor of intermediate malignancy that rarely metastasizes and tends to arise in the lower limbs of young adults and children. Histologically, PHE shows fascicular proliferation of eosinophilic spindle cells and/or epithelioid cells showing "pseudomyogenic" morphology. Immunohistochemically, PHE is usually positive for vimentin, cytokeratin, CD31 and ERG. METHOD: We examined FOSB immunohistochemistry (IHC) in 27 cases consisting of 4 PHE and its histologic mimics including 6 epithelioid hemangioendotheliomas (EHE), 8 angiosarcomas (AS), 4 Kaposi sarcomas (KS) and 5 epithelioid sarcomas (ES)...
August 11, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27510689/pulmonary-hemangioendothelioma-with-osteoclast-like-giant-cells-a-rare-observation
#16
Shraddha A Adamane, Kedar K Deodhar, Amit M Gupta, George Karimundackal, Sangeeta B Desai
Pulmonary epithelioid hemangioendothelioma (PEH) is a rare vascular neoplasm, predominantly encountered in women, more often in the age group of 40 years and below. It is a tumor of borderline malignant potential with a clinical course intermediate between hemangioma and angiosarcoma. The tumor has variable prognosis, and treatment options include surgical excision in operable cases and chemotherapy in disseminated ones. The present report describes complete clinical, radiological, and histopathological features of PEH with osteoclast-like giant cells and metaplastic ossification in a 20-year-old boy who presented with dyspnea and episodes of hemoptysis with review of literature...
July 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27493191/epithelioid-sarcoma-like-hemangioendothelioma-on-the-chest-wall
#17
Norifumi Tsubokawa, Hiroaki Harada, Daiki Taniyama, Takahiro Uemura, Kazuya Kuraoka, Yoshinori Yamashita
Epithelioid sarcoma-like hemangioendothelioma is a rare vascular neoplasm that usually occurs in the distal extremities of young adults. Although the overall behavior of this neoplasm is usually indolent with a low risk of distant metastasis, the risk of local recurrence is significant. Therefore, initial surgical treatment with an adequate margin is important to improve the prognosis. However, epithelioid sarcoma-like hemangioendothelioma is frequently misdiagnosed. A preoperative misdiagnosis could result in resection without a sufficient margin...
October 2016: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/27489719/ambiguous-presentations-of-pulmonary-epithelioid-hemangioendothelioma-two-case-reports-of-a-rare-pulmonary-malignancy
#18
Chun Ian Soo, Boon Hau Ng, Eng Liang Tan, Faisal Abdul Hamid
Pulmonary epithelioid hemangioendothelioma is an uncommon lung malignancy of endothelial origin. Besides demonstrating unpredictable presentation features and prognosis, the paucity of established treatment guidelines remains a challenge in managing these patients. We present two patients. The first patient presented with chronic productive cough over 1-year duration. He was initially diagnosed and showed partial response to treatment for cardiac failure. A persistent right upper zone consolidation on chest radiograph prompted further investigations which revealed the diagnosis of pulmonary epithelioid hemangioendothelioma...
2016: SAGE open medical case reports
https://www.readbyqxmd.com/read/27479949/recurrence-of-epithelioid-hemangioendothelioma-during-pregnancy-case-report-and-systematic-review
#19
REVIEW
Michael Mcculloch, Michael Russin, Arian Nachat
INTRODUCTION: Epithelioid hemangioendothelioma (EHE) is a family of blood vessel tumors originating in blood vessels, bone, brain, kidney, liver, and lung. EHE is more common in women, and chemotherapy, radiation, and surgery have brought few successes. CASE PRESENTATION: We present a case of a 28-year-old woman whose EHE recurred during pregnancy, suggesting hormonal involvement. We conducted a systematic review to provide analysis and interpretation of the potential significance of her disease recurring, with fatal outcome, during pregnancy...
2016: Permanente Journal
https://www.readbyqxmd.com/read/27472721/epithelioid-hemangioendothelioma-in-the-thorax-clinicopathologic-ct-pet-and-prognostic-features
#20
Jung Han Woo, Tae Jung Kim, Kyung Soo Lee, Tae Sung Kim, Byung-Tae Kim
Little is known about prognostic factors in epithelioid hemangioendothelioma (EHE). We aimed to identify prognostic factors among various clinicopathologic and imaging features of thoracic EHEs.Forty-two patients (male:female = 20:22; median age, 49 years) of EHEs with (n = 19) and without (n = 23) thoracic involvement were included. We reviewed electronic medical records for clinical information and computed tomography (CT) features for thoracic involvement. Differences in demographics and survival outcomes of patients with and without thoracic involvement were assessed...
July 2016: Medicine (Baltimore)
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