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Cathérine Pauline Herter, Erhard Ebmeyer, Sonja Kollers, Viktor Korzun, Willmar Lukas Leiser, Tobias Würschum, Thomas Miedaner
The dwarfing gene Rht24 on chromosome 6A acts in the wheat population 'Solitär × Bussard', considerably reducing plant height without increasing Fusarium head blight severity and delaying heading stage. The introduction of the Reduced height (Rht)-B1 and Rht-D1 semi-dwarfing genes led to remarkable increases in wheat yields during the Green Revolution. However, their utilization also brings about some unwanted characteristics, including the increased susceptibility to Fusarium head blight. Thus, Rht loci that hold the potential to reduce plant height in wheat without concomitantly increasing Fusarium head blight (FHB) susceptibility are urgently required...
February 21, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Massimo Mascolo, Francesca Pagliuca, Claudia Costa, Pierpaolo Di Lorenzo, Massimiliano Scalvenzi, Stefania Staibano
No abstract text is available yet for this article.
August 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Jianing Wei, Wenbo Shao, Xianhui Wang, Jin Ge, Xiangyong Chen, Dan Yu, Le Kang
Chemical communication plays an important role in density-dependent phase change in locusts. However, the volatile components and emission patterns of the migratory locust, Locusta migratoria, are largely unknown. In this study, we identified the chemical compositions and emission dynamics of locust volatiles from the body and feces and associated them with developmental stages, sexes and phase changes. The migratory locust shares a number of volatile components with the desert locust (Schistocerca gregaria), but the emission dynamics of the two locust species are significantly different...
February 2017: Insect Science
Peter Zauber, Stephen P Marotta, Marlene Sabbath-Solitare
Mutations of the gene GNAS have been shown to activate the adenylate cyclase gene and lead to constitutive cAMP signaling. Several preliminary reports have suggested a role for GNAS gene mutations during colorectal carcinogenesis, particularly mucinous carcinomas. The aim of this study was to clarify the incidence of GNAS mutations in adenomas (tubular, tubulovillous, and villous), carcinomas with residual adenoma, and carcinomas, and to relate these findings to mutations of the KRAS gene and to the mucinous status of the tumors...
2016: International Journal of Molecular Epidemiology and Genetics
Peter Zauber, Stephen Marotta, Marlene Sabbath-Solitare
BACKGROUND: Changes in the number of alleles of a chromosome may have an impact upon gene expression. Loss of heterozygosity (LOH) indicates that one allele of a gene has been lost, and knowing the exact copy number of the gene would indicate whether duplication of the remaining allele has occurred. We were interested to determine the copy number of the Adenomatous Polyposis Coli (APC) gene in sporadic colorectal cancers with LOH. METHODS: We selected 38 carcinomas with LOH for the APC gene region of chromosome 5, as determined by amplification of the CA repeat region within the D5S346 loci...
March 12, 2016: BMC Cancer
Peter Zauber, Stephen Marotta, Marlene Sabbath-Solitare
Sporadic colorectal cancers with microsatellite instability (MSI) frequently contain a mutation of the BRAF gene. Additionally, it has been shown that BRAF mutations in colorectal cancers are mutually exclusive of KRAS mutation. We evaluated 14 cases of colorectal cancer with MSI that were BRAF wild type but demonstrated a KRAS mutation. The codon 12/13 region in exon 2 of the KRAS oncogene and the codon 600 region in exon 15 of the BRAF gene were analyzed with standard PCR methods. MSI was evaluated by using the Bethesda panel of markers...
2015: Cytogenetic and Genome Research
Jae-Hyung Choi, Hyun-Seok Park, Dae-Hyun Kim, Jae-Kwan Cha, Jae-Taeck Huh, Myongjin Kang
BACKGROUND: Higher reperfusion rates have been established with endovascular treatment for acute ischemic stroke patients. There are limited data on the comparative performance of mechanical thrombectomy devices. This study aimed to analyse the efficacy and safety of the stent retriever device (Solitaire stent) by comparing procedure time, angiographic outcome, complication rate and long term clinical outcome with previous chemical thrombolysis and mechanical thrombectomy using penumbra system...
May 2015: Journal of Korean Neurosurgical Society
Li-Qiang Zheng, Xiang-Chun Han, Yong Huang
No abstract text is available yet for this article.
May 2015: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Xiaojiao Guo, Zongyuan Ma, Le Kang
The migratory locust, Locusta migratoria, shows remarkable phenotypic plasticity at behavioral, physiological, and morphological levels in response to fluctuation in population density. Our previous studies demonstrated that dopamine (DA) and the genes in the dopamine metabolic pathway mediate phase change in Locusta. However, the functions of different dopamine receptors in modulating locust phase change have not been fully explored. In the present study, DA concentration in the brain increased during crowding and decreased during isolation...
2015: Frontiers in Behavioral Neuroscience
Peter Zauber, Thad R Denehy, Robert R Taylor, Emelie H Ongcapin, Stephen Marotta, Marlene Sabbath-Solitare
OBJECTIVE: Endometrial cancer (EC) results from the accumulation of numerous genetic abnormalities contributing to the progression from hyperplasia to EC. Information on these various genetic changes has been primarily derived from studying groups of either hyperplasias or cancers.We evaluated both hyperplastic and EC tissue obtained from the same surgical specimens for KRAS mutations, microsatellite instability (MSI), and mismatch repair gene methylation, and results were correlated between the paired hyperplastic tissue and EC...
June 2015: International Journal of Gynecological Cancer
Ahmad M Alessi, Vincent O'Connor, Hitoshi Aonuma, Philip L Newland
Phenotypic plasticity allows animals to modify their behavior, physiology, and morphology to adapt to environmental change. The global pest, the desert locust, shows two extreme phenotypes; a solitarious phase that is relatively harmless and a gregarious phase that forms swarms and causes extensive agricultural and economic damage. In the field, environmental conditions can drive isolated animals into crowded populations and previous studies have identified the biogenic amine serotonin as a key determinant of this transition...
2014: Frontiers in Behavioral Neuroscience
Peter Zauber, Timothy Bishop, Claire Taylor, Marlene Sabbath-Solitare, Stephen Marotta, Ian Tomlinson
PURPOSE: APC*I1307K (c.3920T>A) is an inherited variant associated with colorectal tumour risk found almost exclusively in those of Ashkenazi Jewish ancestry. A single nucleotide substitution creates an oligo-adenine tract (A8) that appears to be inherently prone to further mis-pairing and slippage. The reported multiple tumor phenotype of carriers is not easily reconciled with molecular and population genetics data. We postulated that some c.3920T>A carriers with multiple adenomas have other unidentified APC germ line or somatic mutations...
2014: PloS One
Peter Zauber, Stephen P Marotta, Marlene Sabbath-Solitare
APC*E1317Q is a low-penetrance variant of the APC gene suggested as a risk for the development of colorectal adenomas and carcinomas. There is very little in the literature describing the molecular details of APC*E1317Q in tumor tissue. We provide information about the molecular genetics of 3 patients with APC*E1317Q. For 1 patient, we show linkage to a specific APC allele. We further show that loss of heterozygosity of the APC gene in tumors from carriers of the APC*E1317Q mutation may involve the mutated allele, not just the wild-type allele, suggesting the APC*E1317Q missense mutation may not be pathologically significant in the development of colorectal tumors...
September 2013: Diagnostic Molecular Pathology: the American Journal of Surgical Pathology, Part B
Peter Zauber, Jiaying Huang, Marlene Sabbath-Solitare, Stephen Marotta
Synchronous and metachronous colorectal cancers are distinct primary neoplasms diagnosed either simultaneously or sequentially in the same patient. Because they arise in a common genetic and environmental background, they offer a unique opportunity to study molecular genetic changes occurring during carcinogenesis. We evaluated tumors from 50 patients with synchronous and five additional patients with metachronous cancers for loss of heterozygosity of the genes APC and DCC, KRAS and BRAF gene mutations, and microsatellite instability and methylation...
September 2013: Journal of Molecular Diagnostics: JMD
Peter Zauber, Stephen Marotta, Marlene Sabbath-Solitare
We have evaluated the frequency of KRAS gene mutations during the critical transition from villous adenoma to colorectal carcinoma to assess whether the adenomas contain a KRAS mutation more frequently than carcinomas. We analyzed sporadic villous and tubulovillous adenomas, in situ carcinomas, and primary colorectal carcinomas from multiple patients. The cancers were further evaluated for mucinous status and microsatellite instability. Standard PCR molecular techniques were used for KRAS and microsatellite analyses...
2013: International Journal of Molecular Epidemiology and Genetics
Seiji Tanaka, Yudai Nishide
Schistocerca gregaria exhibits a phase-specific behavior in response to crowding. Nymphs occurring at low population densities (solitarious phase) tend to avoid one another, whereas those occurring at high population densities (gregarious phase) are attracted to one another. This study examined how this attraction/avoidance behavior changed after isolation or crowding. The behavior of the test nymphs was assessed by determining their positioning with respect to a stimulus cup, which contained 12 gregarious nymphs, placed at one end of an elliptical arena and an empty cup placed at the opposite end...
January 2013: Journal of Insect Physiology
Peter Zauber, Errol Berman, Stephen Marotta, Marlene Sabbath-Solitare, Timothy Bishop
OBJECTIVE: Low-grade mucinous tumors of the appendix appear to have a simple histological structure. Paradoxically, reports have suggested a greater frequency of Ki-ras gene mutation in these lesions than in more complex lesions such as benign colonic adenomas and carcinomas. We assessed several molecular genetic changes, including Ki-ras gene mutations, in a large series of low-grade mucinous tumors of the appendix. MATERIAL AND METHODS: We retrospectively ascertained low-grade mucinous tumors of the appendix from computerized pathology records...
July 2011: Scandinavian Journal of Gastroenterology
N Peter Zauber, Thad R Denehy, Robert R Taylor, Emelie H Ongcapin, Stephen P Marotta, Marlene Sabbath-Solitare, Renuka Kulkarni, Tana Shah Pradhan, Daniela Hermelin, D Timothy Bishop
INTRODUCTION: Molecular genetic changes in endometrial cancers are important to identify possible family cancer syndromes and thus, to facilitate appropriate screening. Most studies in this regard have focused primarily on young women. We have assayed cancers for microsatellite instability (MSI) and DNA methylation from a large group of patients younger than 50 years and a comparable group of older women. We obtained personal and medical histories of the patients and their family cancer histories...
December 2010: International Journal of Gynecological Cancer
Wei Guo, Xianhui Wang, Zongyuan Ma, Liang Xue, Jingyao Han, Dan Yu, Le Kang
Behavioral plasticity is the most striking trait in locust phase transition. However, the genetic basis for behavioral plasticity in locusts is largely unknown. To unravel the molecular mechanisms underlying the behavioral phase change in the migratory locust Locusta migratoria, the gene expression patterns over the time courses of solitarization and gregarization were compared by oligonucleotide microarray analysis. Data analysis revealed that several gene categories relevant to peripheral olfactory perception are strongly regulated in a total of 1,444 differentially expressed genes during both time courses...
February 3, 2011: PLoS Genetics
Bruce M Solitar
Fibromyalgia is a chronic syndrome of diffuse musculoskeletal pain with tenderness at specific locations, often associated with persistent fatigue, cognitive and mood disorders, joint stiffness, and insomnia. Understanding the pathophysiology of fibromyalgia and the establishment of effective treatments have been complex endeavors that have not yielded simple answers. Nevertheless, recent studies have shed light on the roles of central pain processing, genetic abnormalities, and external factors on development of the fibromyalgia syndrome (FMS)...
2010: Bulletin of the NYU Hospital for Joint Diseases
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