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https://www.readbyqxmd.com/read/29668016/genetic-and-ecological-niche-modeling-of-calydorea-crocoides-iridaceae-an-endemic-species-of-subtropical-highland-grasslands
#1
Juliana Lustosa Matos de Alencar, Eliane Kaltchuk-Santos, Juliana Fachinetto, Luana Olinda Tacuatiá, Eliana Regina Forni-Martins, Eudes Maria Stiehl-Alves, Tatiana Teixeira de Souza-Chies
Evolutionary analyses have been widely used for evaluation of genetic diversity of natural populations and correlate these data to the fitness of the species, especially in the case of threatened species. Calydorea crocoides occurs in a restricted area at altitudes from 800 to 1500 m in southern Brazil and is considered endangered. A study assessing genetic diversity, cytogenetic features and ecological niche was performed aiming to characterize C. crocoides by multidisciplinary approaches. Molecular data highlighted that most of the total variation (76%; p < 0...
2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29667256/procalcitonin-and-c-reactive-protein-as-biomarkers-for-neonatal-bacterial-infection
#2
Ashfaque F Quadir, Philip N Britton
AIM: Neonates are predisposed to bacterial infection which are an important cause of early childhood morbidity and mortality globally. It has been proposed that procalcitonin has significant utility as a diagnostic marker for bacterial infection in febrile neonates when compared to C-reactive protein (CRP). The aim of this study is to conduct a literature search to find the best available evidence to answer the clinical question of the utility of procalcitonin when compared to CRP as a predictor of bacterial infection in febrile neonates...
April 17, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29667017/underestimated-prevalence-of-heart-failure-in-hospital-inpatients-a-comparison-of-icd-codes-and-discharge-letter-information
#3
Mathias Kaspar, Georg Fette, Gülmisal Güder, Lea Seidlmayer, Maximilian Ertl, Georg Dietrich, Helmut Greger, Frank Puppe, Stefan Störk
BACKGROUND: Heart failure is the predominant cause of hospitalization and amongst the leading causes of death in Germany. However, accurate estimates of prevalence and incidence are lacking. Reported figures originating from different information sources are compromised by factors like economic reasons or documentation quality. METHODS: We implemented a clinical data warehouse that integrates various information sources (structured parameters, plain text, data extracted by natural language processing) and enables reliable approximations to the real number of heart failure patients...
April 17, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29666794/on-the-difference-between-additive-and-subtractive-qm-mm-calculations
#4
Lili Cao, Ulf Ryde
The combined quantum mechanical (QM) and molecular mechanical (MM) approach (QM/MM) is a popular method to study reactions in biochemical macromolecules. Even if the general procedure of using QM for a small, but interesting part of the system and MM for the rest is common to all approaches, the details of the implementations vary extensively, especially the treatment of the interface between the two systems. For example, QM/MM can use either additive or subtractive schemes, of which the former is often said to be preferable, although the two schemes are often mixed up with mechanical and electrostatic embedding...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29664752/two-point-method-for-measuring-the-temporal-modulation-transfer-function
#5
Takashi Morimoto, Toshio Irino, Kouta Harada, Takeshi Nakaichi, Yasuhide Okamoto, Ayako Kanno, Sho Kanzaki, Kaoru Ogawa
OBJECTIVE: The temporal modulation transfer function (TMTF) has been proposed to estimate the temporal resolution abilities of listeners with normal hearing and listeners with hearing loss. The TMTF data of patients would be useful for clinical diagnosis and for adjusting the hearing instruments at clinical and fitting sites. However, practical application is precluded by the long measurement time of the conventional method, which requires several measurement points. This article presents a new method to measure the TMTF that requires only two measurement points...
April 16, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29664128/continuous-improvement-of-a-groundwater-model-over-a-20-year-period-lessons-learned
#6
Peter F Andersen, James L Ross, Jon P Fenske
Groundwater models developed for specific sites generally become obsolete within a few years due to changes in: 1) modeling technology, 2) site/project personnel, 3) project funding, and 4) modeling objectives. Consequently, new models are sometimes developed for the same sites using the latest technology and data, but without potential knowledge gained from the prior models. When it occurs, this practice is particularly problematic because, although technology, data, and observed conditions change, development of the new numerical model may not consider the conceptual model's underpinnings...
April 17, 2018: Ground Water
https://www.readbyqxmd.com/read/29663836/computational-modeling-of-human-oral-bioavailability-what-will-be-next
#7
Miguel Ángel Cabrera-Pérez, Hai Pham-The
The oral route is the most convenient way of administrating drugs. Therefore, accurate determination of oral bioavailability is paramount during drug discovery and development. Quantitative structure-property relationship (QSPR), rule-of-thumb (RoT) and physiologically based-pharmacokinetic (PBPK) approaches are promising alternatives to the early oral bioavailability prediction. Areas covered: The authors give insight into the factors affecting bioavailability, the fundamental theoretical framework and the practical aspects of computational methods for predicting this property...
April 17, 2018: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29663512/specific-biomarkers-of-myocardial-inflammation-and-remodeling-processes-as-predictors-of-mortality-in-high-risk-patients-undergoing-percutaneous-mitral-valve-repair-mitraclip
#8
Oliver Dörr, Claudia Walther, Christoph Liebetrau, Till Keller, Hannes Tabert, Niklas Boeder, Matthias Bayer, Pascal Bauer, Helge Möllmann, Luise Gaede, Christian Troidl, Sandra Voss, Timm Bauer, Christian W Hamm, Holger Nef
BACKGROUND: Specific matrix metalloproteinases (MMP-2, MMP-9) and inflammatory biomarkers (hsCRP, IL-6) were found to be consistently up-regulated in severe mitral valve regurgitation (MR) and are associated with mortality in heart failure patients. The aim of the present study was to examine the prognostic value of biomarkers of cardiac inflammation and remodeling processes in predicting mortality in patients with MR undergoing percutaneous mitral valve repair (PMVR). HYPOTHESIS: We hypothesize that increased cardiac inflammation and extracellular matrix turnover is predictive for mortality in patients with severe mitral regurgitation undergoing MitraClip...
April 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29663492/efficacy-of-epinephrine-free-articaine-compared-to-articaine-with-epinephrine-1-100-000-for-maxillary-infiltration-a-randomized-clinical-trial
#9
Konstantinos Paterakis, Marc Schmitter, Sareh Said Yekta-Michael
OBJECTIVE: The selection of local anesthetic in dental practice is essential to the patient's comfort and the success of the treatment. Many patients prefer anesthesia even for short treatments. Articaine is a local anesthetic commonly used for dental practice. The duration of the effect of articaine on the nerve fibers is not yet precisely reported. This study was aimed to evaluate the clinical efficacy of 4% articaine with and without epinephrine in treatment of occlusal caries. MATERIALS AND METHODS: Thirty healthy patients were included in this randomized double-blind study...
April 16, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29663483/differences-in-the-oral-health-status-and-oral-hygiene-practices-according-to-the-extent-of-post-stroke-sequelae
#10
Hyeong Tae Kim, Jong Bum Park, Won Chul Lee, Yeun Ju Kim, Y Lee
Oral health and hygiene are crucial parameters in stroke patients. However, few studies has evaluated the oral health status and oral hygiene practices according to the level of function in stroke patients. The aim of the present study was to evaluate the oral health status and oral hygiene practices according to ambulation and personal hygiene levels in patients with stroke. Data from the fifth (2010-2012) and sixth (2013-2015) editions of the Korea National Health and Nutrition Examination Survey (KNHANES) for 6 years combined...
April 16, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29663430/effectiveness-of-a-new-single-needle-single-pump-dialysis-system-with-simultaneous-monitoring-of-dialysis-dose
#11
Wolfgang Bieser, Markus Welsch, Marten Jakob, Jörn Meibaum, David A Rodriguez, Henrik Wolff, Daniele Marcelli, Claudia Barth
To date, single-needle (SN) hemodialysis (HD) requires a dialysis machine equipped with two blood pumps-one controlling arterial blood flow (Qb) and one controlling venous Qb. B. Braun has developed an innovative single-pump SN HD system. Therefore, usability is improved by reducing complexity. The aim of this study was to compare dialysis parameters of the new single-pump SN HD system with a double-pump SN HD system available on the market (Fresenius Medical Care [FMC] 5008). In this two-armed crossover study, patients were randomized into two groups (B...
April 16, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29663103/cacha%C3%A3-a-yeast-strains-alternative-starters-to-produce-beer-and-bioethanol
#12
Thalita Macedo Araújo, Magalhães Teixeira Souza, Raphael Hermano Santos Diniz, Celina Kiyomi Yamakawa, Lauren Bergmann Soares, Jaciane Lutz Lenczak, Juliana Velasco de Castro Oliveira, Gustavo Henrique Goldman, Edilene Alves Barbosa, Anna Clara Silva Campos, Ieso Miranda Castro, Rogelio Lopes Brandão
This work was performed to verify the potential of yeast strains isolated from cachaça distilleries for two specific biotechnological applications: beer and bioethanol production. In the beer production, the strains were tested for characteristics required in brewery practices, such as: capacity to ferment maltose and maltotriose, ability to grow at lowest temperatures, low H2 S production, and flocculation profile. Among the strains tested, two of them showed appropriate characteristics to produce two different beer styles: lager and ale...
April 16, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29662919/development-and-clinical-validation-of-a-hybrid-method-for-semiautomated-left-ventricle-endocardial-and-epicardial-boundary-extraction-on-cine-magnetic-resonance-images
#13
Mahammed Messadi, Abdelhafid Bessaid, Denis Mariano-Goulart, Fayçal Ben Bouallègue
We describe a hybrid method for left ventricle (LV) endocardial and epicardial segmentation on cardiac magnetic resonance (CMR) images requiring minimal operator intervention. Endocardium extraction results from the union of three independent estimations based on adaptive thresholding, region growing, and active contour with Chan-Vese energy function. Epicardium segmentation relies on conditional morphological dilation of the endocardial mask followed by active contour optimization. The proposed method was first evaluated using an open access database of 18 CMR for which expert manual contouring was available...
April 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29662769/human-and-bovine-spinal-disc-mechanics-subsequent-to-trypsin-injection
#14
Jeremy Alsup, Timothy Bishop, Dennis Eggett, Anton E Bowden
Objective: To investigate the biomechanical effects of injections of a protease on the characteristics of bovine coccygeal and human lumbar disc motion segments. Methods: Mechanics of treated tissues were measured immediately after injection and 3 h after injection. Motion segments underwent axial rotation and flexion-extension loading. Results: Stiffness and neutral zone parameters experienced significant changes over time, with bovine tissues more strongly affected than human cadaver tissues...
October 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662766/clinical-validation-of-a-body-fixed-3d-accelerometer-and-algorithm-for-activity-monitoring-in-orthopaedic-patients
#15
Matthijs Lipperts, Simon van Laarhoven, Rachel Senden, Ide Heyligers, Bernd Grimm
Background/Objective: Activity is increasingly being recognized as a highly relevant parameter in all areas of healthcare for diagnosis, treatment, or outcome assessment, especially in orthopaedics where the movement apparatus is directly affected. Therefore, the aim of this study was to develop, describe, and clinically validate a generic activity-monitoring algorithm, satisfying a combination of three criteria. The algorithm must be able to identify, count, and time a large set of relevant daily activities...
October 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662345/stochastic-isotropic-hyperelastic-materials-constitutive-calibration-and-model-selection
#16
L Angela Mihai, Thomas E Woolley, Alain Goriely
Biological and synthetic materials often exhibit intrinsic variability in their elastic responses under large strains, owing to microstructural inhomogeneity or when elastic data are extracted from viscoelastic mechanical tests. For these materials, although hyperelastic models calibrated to mean data are useful, stochastic representations accounting also for data dispersion carry extra information about the variability of material properties found in practical applications. We combine finite elasticity and information theories to construct homogeneous isotropic hyperelastic models with random field parameters calibrated to discrete mean values and standard deviations of either the stress-strain function or the nonlinear shear modulus, which is a function of the deformation, estimated from experimental tests...
March 2018: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29662308/hypoglycemic-and-antioxidant-effect-of-tai-chi-exercise-training-in-older-adults-with-metabolic-syndrome
#17
Víctor Manuel Mendoza-Núñez, Taide Laurita Arista-Ugalde, Juana Rosado-Pérez, Mirna Ruiz-Ramos, Edelmiro Santiago-Osorio
Introduction: The antioxidant and anti-inflammatory effects of Tai chi (TC) exercise training in healthy older adults has been demonstrated. However, there are no studies on this effect in older adults with metabolic syndrome (MetS). Purpose: The aim of this study was to determine the effect of TC exercise on oxidative stress and inflammatory markers in older adults with MetS. Methods: A quasi-experimental study was carried out with a sample of 110 older sedentary volunteers with clinical diagnoses of MetS: (i) a control group, n = 50, of individuals who do not participate in physical exercise, of which 37 fulfilled the entire study protocol, and (ii) an experimental group, n = 60, of subjects enrolled in a TC exercise training program (eight-form easy), 5 days a week for 6 months, in sessions of 50 min, under the supervision of a qualified instructor, of which 48 fulfilled the entire study protocol...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29661718/the-gleason-pattern-4-in-radical-prostatectomy-specimens-in-current-practice-quantification-morphology-and-concordance-with-biopsy
#18
Maiara Ferreira de Souza, André Luis Cardoso de Azevedo Araujo, Mariana Trindade da Silva, Daniel Abensur Athanazio
PURPOSE: The upgrading of a prostate acinar adenocarcinoma grade group 1 (GG1) between needle biopsy and prostatectomy is common. The extent of high-grade tumor and cribriform morphology are currently suggested as prognostic factors. METHODS: We reviewed 159 prostatectomy specimens from a private laboratory and an academic/public institution in Salvador, Bahia. RESULTS: Tumors signed as GG1 at biopsy were upgraded in 59% of all cases. These tumors showed a low frequency of non-focal extraprostatic extension (one case, 3%), extensive positive surgical margins (two cases, 6%) and seminal vesicle invasion (one case, 3%)...
December 18, 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29661551/control-of-a-manipulator-robot-by-neuro-fuzzy-subsets-form-approach-control-optimized-by-the-genetic-algorithms
#19
Salim Refoufi, Khier Benmahammed
In this paper, we describe a new form of neuro-fuzzy-genetic controller design for nonlinear system derived from a manipulator robot. The proposed method combines fuzzy logic and neuronal networks which are of growing interest in robotics, the neuro-fuzzy controller does not require the knowledge of the robot parameters values. Furtheremore, the genetic algorithms (GAs) for complex motion planning of robots require an evaluation function which takes into account multiple factors. An optimizing algorithm based on the genetic algorithms is applied in order to provide the most adequate shape of the fuzzy subsets that are considered as an interpolation functions...
April 13, 2018: ISA Transactions
https://www.readbyqxmd.com/read/29661270/systematic-review-of-the-evidence-related-to-mandated-nurse-staffing-ratios-in-acute-hospitals
#20
Richard Olley, Ian Edwards, Mark Avery, Helen Cooper
Objective The purpose of this systematic review was to evaluate and summarise available research on nurse staffing methods and relate these to outcomes under three overarching themes of: (1) management of clinical risk, quality and safety; (2) development of a new or innovative staffing methodology; and (3) equity of nursing workload. Methods The PRISMA method was used. Relevant articles were located by searching via the Griffith University Library electronic catalogue, including articles on PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Medline...
April 17, 2018: Australian Health Review: a Publication of the Australian Hospital Association
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