Daniel P Franzen, Martin Brutsche, Jakob Nilsson, Christian Böni, Cécile Daccord, Oliver Distler, Dieter Elsener, Manuela Funke-Chambour, Christiane Gruner, Helen Hayward-Könnecke, Katrin E Hostettler, Thomas Kündig, Camillo Ribi, Jörg D Seebach, Harald Seeger, Bart Vrugt, Antonios G A Kolios
Sarcoidosis is a systemic inflammatory disease, characterised by granuloma formation upon an unknown trigger in genetically predisposed individuals. The inflammation is characterised by an activation of both the innate immune system, with macrophages differentiating into epitheloid cells and dendritic cells, and the adaptive immune system, particularly T helper (Th) 1 and Th17 cells. Since all organs can be affected to varying extents, clinical presentation is often diverse. Most commonly, the lungs, lymph nodes, skin and eyes are involved, whereas cardiac, renal and neurological manifestations are less common but associated with higher morbidity...
January 3, 2022: Swiss Medical Weekly