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https://www.readbyqxmd.com/read/28213577/economic-evaluation-of-universal-prenatal-hiv-screening-compared-with-current-at-risk-policy-in-a-very-low-prevalence-country
#1
Michal Chowers, Oren Shavit
OBJECTIVES: Our objective was to economically evaluate universal HIV prenatal screening in Israel, a very low prevalence country (0.1%), compared with the current policy of testing only women belonging to high-risk (HR) groups. DESIGN: A cost-effectiveness analytical model was constructed. Life expectancies, direct medical costs and utility weights of an HIV-positive newborn and a healthy newborn were derived from the literature. Screening was assessed using fourth-generation combo tests...
March 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28212643/vertical-hiv-transmission-in-perinatally-exposed-infants-in-south-rift-region-of-kenya-a-retrospective-cross-sectional-study
#2
Everline Ashiono, Dunstan Achwoka, Jamlick Mutugi, Joel Rakwar, Andrew Wafula, Otto Nzapfurundi Chabikuli
BACKGROUND: Despite proven efficacy of the prevention mother-to-child transmission of HIV strategy, its adoption in Africa has remained slow. In Kenya, its effectiveness remain unknown. The aim of this study was to assess the effectiveness of a prevention of mother-to-child transmission program in Kenya. METHODS: This retrospective cross-sectional study analyzed 2,642 records of HIV-exposed infants who had a deoxyribonucleic acid polymerase chain reaction test done...
February 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28209189/late-presentation-increases-risk-and-costs-of-non-infectious-comorbidities-in-people-with-hiv-an-italian-cost-impact-study
#3
Giovanni Guaraldi, Stefano Zona, Marianna Menozzi, Thomas D Brothers, Federica Carli, Chiara Stentarelli, Giovanni Dolci, Antonella Santoro, Ana Rita Domingues Da Silva, Elisa Rossi, Julian Falutz, Cristina Mussini
BACKGROUND: Late presentation (LP) at the time of HIV diagnosis is defined as presentation with AIDS whatever the CD4 cell count or with CD4 <350 cells/mm. The objective of our study was to assess the prevalence of non-infectious comorbidities (NICM) and multimorbidity among HIV-positive individuals with and without a history of LP (HIV + LP and HIV + EP, respectively), and compare them to matched HIV-negative control participants from a community-based cohort. The secondary objective was to provide estimates and determinants of direct cost of medical care in HIV patients...
February 16, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28205255/effect-of-postnatal-hiv-treatment-on-clinical-mastitis-and-breast-inflammation-in-hiv-infected-breast-feeding-women
#4
Sabrina Zadrozny, Daniel Westreich, Michael G Hudgens, Charles Chasela, Denise J Jamieson, Francis Martinson, Chifundo Zimba, Gerald Tegha, Irving Hoffman, William C Miller, Brian W Pence, Caroline C King, Athena P Kourtis, Wezi Msungama, Charles van der Horst
BACKGROUND: The relationship between mastitis and antiretroviral therapy among HIV-positive, breast-feeding women is unclear. METHODS: In the Breastfeeding, Antiretrovirals, and Nutrition (BAN) study, conducted in Lilongwe, Malawi, 2369 mother-infant pairs were randomized to a nutritional supplement group and to one of three treatment groups: maternal antiretroviral therapy (ART), infant nevirapine (NVP) or standard of care for 24 weeks of exclusive breast-feeding and 4 weeks of weaning...
February 16, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28203108/a-review-of-screening-strategies-for-cervical-cancer-in-human-immunodeficiency-virus-positive-women-in-sub-saharan-africa
#5
REVIEW
Manuela Viviano, Pierre DeBeaudrap, Pierre-Marie Tebeu, Jovanny T Fouogue, Pierre Vassilakos, Patrick Petignat
Cervical cancer (CC) is a leading cause of cancer-related death and a major public health issue in sub-Saharan Africa. This heavy burden parallels that of the human immunodeficiency virus (HIV) infection, which increases the risk of developing CC. Despite the progressive reduction of HIV prevalence in the past decade, the CC incidence and mortality rates in sub-Saharan Africa remain high. The heterogeneity of the distribution of the two diseases in the African continent, together with the different availability of human and material resources, stands in the way of finding an appropriate screening strategy...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28199532/carcinogenicity-of-human-papillomavirus-types-in-hiv-positive-women-a-meta-analysis-from-hpv-infection-to-cervical-cancer
#6
Gary M Clifford, Stephen Tully, Silvia Franceschi
No abstract text is available yet for this article.
February 12, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28194650/healthy-aging-in-older-women-living-with-hiv-infection-a-systematic-review-of-psychosocial-factors
#7
REVIEW
Anna A Rubtsova, Mirjam-Colette Kempf, Tonya N Taylor, Deborah Konkle-Parker, Gina M Wingood, Marcia McDonnell Holstad
Due to life-enhancing effects of antiretroviral therapy, HIV-positive persons have the potential for long life comparable to their uninfected peers. Older women (age 50+) living with HIV (OWLH) are often an under-recognized aging group. We conducted a systematic review to examine psychosocial factors that impact how OWLH live, cope, and age with HIV. Initial key word search yielded 1527 records, and 21 studies met our inclusion criteria of original quantitative or qualitative research published between 2013 and 2016 with results specific to OWLH...
February 13, 2017: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/28188460/gender-differences-in-hiv-risk-behaviors-among-persons-involved-in-the-u-s-criminal-justice-system-and-living-with-hiv-or-at-risk-for-hiv-a-seek-test-treat-and-retain-harmonization-consortium
#8
Kelsey B Loeliger, Mary L Biggs, Rebekah Young, David W Seal, Curt G Beckwith, Irene Kuo, Michael S Gordon, Frederick L Altice, Lawrence J Ouellet, William E Cunningham, Jeremy D Young, Sandra A Springer
The U.S. female criminal justice (CJ) population is rapidly growing, yet large-scale studies exploring gender-specific HIV risk behaviors in the CJ population are lacking. This analysis uses baseline data on adults with a CJ history from eight U.S. studies in an NIH-funded "Seek, Test, Treat, Retain" harmonization consortium. Data were collected using a standardized HIV risk behavior assessment tool and pooled across studies to describe participants' characteristics and risk behaviors. Multilevel mixed-effects logistic regression models were used to test for gender-based behavior differences...
February 10, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28187506/the-effect-of-gene-variants-on-levonorgestrel-pharmacokinetics-when-combined-with-antiretroviral-therapy-containing-efavirenz-or-nevirapine
#9
M Neary, M Lamorde, A Olagunju, K M Darin, C Merry, P Byakika-Kibwika, D J Back, M Siccardi, A Owen, K K Scarsi
Reduced levonorgestrel concentrations from the levonorgestrel contraceptive implant was previously seen when given concomitantly with efavirenz. We sought to assess whether single nucleotide polymorphisms (SNPs) in genes involved in efavirenz and nevirapine metabolism were linked to these changes in levonorgestrel concentration. SNPs in CYP2B6, CYP2A6, NR1I2 and NR1I3 were analysed. Associations of participant demographics and genotype with levonorgestrel pharmacokinetics were evaluated in HIV-positive women using the levonorgestrel implant plus efavirenz- or nevirapine-based ART, in comparison to ART-naïve women using multivariate linear regression...
February 10, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28187085/genital-systemic-chemokine-gradients-and-the-risk-of-hiv-acquisition-in-women
#10
Lenine J P Liebenberg, Lindi Masson, Kelly B Arnold, Lyle R Mckinnon, Lise Werner, Elizabeth Proctor, Derseree Archary, Leila E Mansoor, Douglas A Lauffenburger, Quarraisha Abdool Karim, Salim S Abdool Karim, Jo-Ann S Passmore
BACKGROUND: Mucosal and systemic immune mediators have been independently associated with HIV acquisition risk, but the relationship between compartments remains unclear. METHODS: To address this, the concentrations of 12 cytokines were compared in matched plasma and cervicovaginal lavages (CVLs) from 57 HIV-positive women before their acquisition of HIV (cases) and 50 women who remained uninfected (controls) during the CAPRISA 004 trial. RESULTS: Although genital IP-10 concentrations were significantly higher in cases, plasma IP-10 concentrations were inversely associated with HIV risk...
March 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28185022/correlates-of-double-risk-of-hiv-acquisition-and-transmission-among-women-who-inject-drugs-in-st-petersburg-russia
#11
Polina Girchenko, Elizabeth J King
Russia continues to experience a growing HIV epidemic, and women account for an increasing proportion of new HIV diagnoses in the country. This study aims to provide up-to-date information on factors associated with unsafe sex and drug use behaviors among women who inject drugs in St. Petersburg, Russia. In this community-based sample of 500 women who inject drugs, 64% tested positive for HIV. Women reported the following: 21% reported injection risk, 22% reported sexual risk, and 18% reported double risk. Multivariable analyses using logistic multinomial regression showed that older age is associated with increased risk behaviors...
February 9, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28183852/incarceration-and-exposure-to-internally-displaced-persons-camps-associated-with-reproductive-rights-abuses-among-sex-workers-in-northern-uganda
#12
Margaret Erickson, Shira M Goldenberg, Monica Akello, Godfrey Muzaaya, Paul Nguyen, Josephine Birungi, Kate Shannon
BACKGROUND: While female sex workers (FSWs) face a high burden of violence and criminalisation, coupled with low access to safe, non-coercive care, little is known about such experiences among FSWs in conflict-affected settings, particularly as they relate to sexual and reproductive health (SRH) and rights. We explored factors associated with lifetime abortions among FSWs in northern Uganda; and separately modelled the independent effect of lifetime exposures to incarceration and living in internally displaced persons (IDP) camps on coerced and unsafe abortions...
February 9, 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/28182610/pharmacokinetics-and-safety-of-darunavir-ritonavir-in-hiv-infected-pregnant-women
#13
Saye Khoo, Gilles Peytavin, David Burger, Andrew Hill, Kimberley Brown, Christiane Moecklinghoff, Charles La Porte, Maria Blanca Hadacek
The dosage of darunavir/ritonavir is 800/100 mg once daily for treatment-naive patients or treatment-experienced patients with no prior darunavir resistance associated mutations, and 600/100 mg twice daily for treatment-experienced patients with one or more darunavir resistance associated mutations. Results from the five available pharmacokinetic studies show reductions in total darunavir plasma concentrations of between 20-50% during the third trimester of pregnancy. The unbound darunavir concentrations have been measured only in subsets of patients in two of the five pharmacokinetic studies...
January 2017: AIDS Reviews
https://www.readbyqxmd.com/read/28181013/factors-associated-with-receiving-late-hiv-testing-among-women-delivering-at-hung-vuong-hospital-ho-chi-minh-city-vietnam-2014
#14
V N Khuu, V T Nguyen, N K Hills, T P Hau, D P Nguyen, V T Nhung, P T Lan, D B Brickley
HIV testing during pregnancy facilitates timely antiretroviral treatment for HIV-positive women. This study identifies reasons for late HIV testing among pregnant women delivering at a hospital in Ho Chi Minh City. We conducted a case-control study in which 160 cases were women who were tested for HIV late (i.e., at labor and delivery) and 160 controls were women who were tested during antenatal care (ANC). In multivariable logistic regression analysis, six variables were associated with late HIV testing: age less than 30 years, nine or fewer years of education, working as a homemaker or worker/farmer, living 20 km or more from the hospital, having received ANC at a private clinic/hospital only, and not believing that HIV testing is important during pregnancy...
February 8, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28180012/seroprevalence-and-co-infection-of-human-immunodeficiency-virus-hiv-and-herpes-simplex-virus-hsv-among-pregnant-women-in-lokoja-north-central-nigeria
#15
Olatunji Matthew Kolawole, Oluwatomi Olufunke Amuda, Charles Nzurumike, Muhammed Mustapha Suleiman, Jeremiah Ikhevha Ogah
BACKGROUND: Herpes simplex virus 1 (HSV-1) is normally associated with orofacial (orolabial) infections and encephalitis, whereas HSV-2 usually causes genital infections and can be transmitted from infected mothers to neonates. The evidence suggesting that HSV is facilitating the spread of the global human immunodeficiency virus (HIV) epidemic and the risk posed by these synergies to neonates in developing countries informed this study. OBJECTIVES: To determine the seroprevalence and co-infection of HIV and HSV, as well as their associated risk factors, in Lokoja, Nigeria...
October 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28178993/perspectives-of-urban-ghanaian-women-on-vasectomy
#16
Ofeibea Asare, Easmon Otupiri, Joana Apenkwa, Rose Odotei-Adjei
BACKGROUND: Advocacy for male involvement in family planning has been championed over the years after the 1994 International Conference on Population and Development (ICPD). There are a few contraceptive methods for men, and vasectomy uptake has been identified as one of the indicators of male involvement in family planning. Vasectomy also known as male sterilization is a permanent form of contraception. It is a generally safe, quick, easy, effective surgical operation with rare complications to prevent release of sperm...
February 8, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28178892/trends-in-the-incidence-of-aids-defining-and-non-aids-defining-cancers-in-people-living-with-aids-a-population-based-study-from-s%C3%A3-o-paulo-brazil
#17
Luana F Tanaka, Maria do Rosário DO Latorre, Eliana B Gutierrez, Christian Heumann, Karl-Heinz Herbinger, Guenter Froeschl
People living with AIDS are at increased risk of developing certain cancers. Since the introduction of the highly active antiretroviral therapy (HAART), the incidence of AIDS-defining cancers (ADCs) has decreased in high-income countries. The objective of this study was to analyse trends in ADCs and non-AIDS-defining cancers (NADCs) in HIV-positive people with a diagnosis of AIDS, in comparison to the general population, in São Paulo, Brazil. A probabilistic record linkage between the 'Population-based Cancer Registry of São Paulo' and the AIDS notification database (SINAN) was conducted...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28178111/demographics-behaviors-and-sexual-health-characteristics-of-high-risk-men-who-have-sex-with-men-and-transgender-women-who-use-social-media-to-meet-sex-partners-in-lima-peru
#18
Jeremy Y Chow, Kelika A Konda, Gino M Calvo, Jeffrey D Klausner, Carlos F Cáceres
BACKGROUND: Men who have sex with men (MSM) and transgender women (TW) in Peru bear a disproportionate burden of human immunodeficiency virus (HIV) and sexually transmitted infections (STIs). In a context of quickly expanding communication technology, increasing numbers of MSM and TW are using social media applications to seek sex partners. Understanding social media users and their sex partnering practices is needed to update HIV and STI prevention programming. METHODS: In Lima, Peru, 312 MSM and 89 TW from 2 STI clinics underwent HIV and STI testing and participated in a survey of demographics, behaviors, sexual health, and social media practices...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28178109/risk-factors-for-incidence-of-sexually-transmitted-infections-among-women-in-a-human-immunodeficiency-virus-chemoprevention-trial-voice-mtn-003
#19
Zvavahera Mike Chirenje, Holly M Gundacker, Barbra Richardson, Lorna Rabe, Zakir Gaffoor, Gonasagrie Lulu Nair, Brenda Gati Mirembe, Jeanna M Piper, Sharon Hillier, Jeanne Marrazzo
BACKGROUND: In sub-Saharan Africa, there are limited data on the incidence of sexually transmitted infections (STIs) among women, largely because routine screening for asymptomatic infection is not performed. We conducted a secondary analysis to measure STI incidence rates and determine risk factors for new STI acquisition among women enrolled in the VOICE trial. METHODS: We analyzed data from 4843 women screened for chlamydia, gonorrhoea, syphilis, and trichomonas infection at baseline, annually, at interim visits when clinically indicated and at their study termination visit...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28173785/hcv-screening-in-a-cohort-of-hiv-infected-and-uninfected-homeless-and-marginally-housed-women-in-san-francisco-california
#20
Kimberly Page, Michelle Yu, Jennifer Cohen, Jennifer Evans, Martha Shumway, Elise D Riley
BACKGROUND: Hepatitis C virus (HCV) screening has taken on new importance as a result of updated guidelines and new curative therapies. Relatively few studies have assessed HCV infection in homeless populations, and a minority include women. We assessed prevalence and correlates of HCV exposure in a cohort of homeless and unstably housed women in San Francisco, and estimated the proportion undiagnosed. METHODS: A probability sample of 246 women were recruited at free meal programs, homeless shelters, and low-cost single room occupancy hotels in San Francisco; women with HIV were oversampled...
February 7, 2017: BMC Public Health
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