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https://www.readbyqxmd.com/read/28930196/socio-demographic-and-lifestyle-factors-predict-5-year-changes-in-adiposity-among-a-group-of-black-south-african-adults
#1
Cornelie Nienaber-Rousseau, Olusola F Sotunde, Patricia O Ukegbu, P Hermanus Myburgh, Hattie H Wright, Lize Havemann-Nel, Sarah J Moss, Iolanthé M Kruger, H Salomé Kruger
The rising prevalence of obesity and excessive adiposity are global public health concerns. Understanding determinants of changes in adiposity over time is critical for informing effective evidence-based prevention or treatment. However, limited information is available to achieve this objective. Cultural, demographic, environmental, and behavioral factors including socio-economic status (SES) likely account for obesity development. To this end, we related these variables to anthropometric measures in 1058 black adult Tswana-speaking South Africans who were HIV negative in a prospective study over five years...
September 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28926408/serum-glycan-binding-igg-antibodies-in-hiv-1-infection-and-during-the-development-of-broadly-neutralizing-responses
#2
Cathrine Scheepers, Sudipa Chowdhury, W Shea Wright, Christopher T Campbell, Nigel J Garrett, Quarraisha Abdool Karim, Salim S Abdool Karim, Penny L Moore, Jeffrey C Gildersleeve, Lynn Morris
BACKGROUND: The HIV-1 envelope is covered with glycans that provide structural integrity and protect conserved regions from host antibody responses. However, these glycans are often the target of broadly neutralizing antibodies (bNAbs) that emerge in some HIV infected individuals. We aimed to determine whether anti-glycan IgG antibodies are a general response to HIV-1 infection or specific to individuals who develop bNAbs. METHODS: IgG binding to glycans was assessed using arrays that contained 245 unique components including N-linked carbohydrates, glycolipids and Tn-peptides...
September 18, 2017: AIDS
https://www.readbyqxmd.com/read/28923034/an-implementation-science-protocol-of-the-women-s-health-coop-in-healthcare-settings-in-cape-town-south-africa-a-stepped-wedge-design
#3
Wendee M Wechsberg, Jacqueline W Ndirangu, Ilene S Speizer, William A Zule, Winnifred Gumula, Courtney Peasant, Felicia A Browne, Laura Dunlap
BACKGROUND: HIV persists as a public health emergency in South Africa, especially among women of childbearing age. In response to the HIV epidemic, the Joint United Nations Programme on HIV/AIDS has put forth the 90-90-90 global goals to achieve an AIDS-free generation by 2020. This goal aspires to have 90% of people living with HIV diagnosed; 90% of those who test positive on sustained antiretroviral therapy (ART); and 90% of those on ART be virally suppressed. Ensuring access to ART is an important first step in reducing HIV incidence, especially among vulnerable populations such as women who use substances and bear the burden of HIV in South Africa...
September 18, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28922093/safer-sexual-practices-among-african-american-women-intersectional-socialisation-and-sexual-assertiveness
#4
Danice L Brown, Sha'Kema Blackmon, Alexandra Shiflett
Scholars have posited that childhood socialisation experiences may play a key role in influencing behaviours and attitudes that contribute to the acquisition of HIV. This study examined the links between past ethnic-racial and gender socialisation, sexual assertiveness and the safe sexual practices of African American college women utilising a cluster analytic approach. After identifying separate racial-gender and ethnic-gender socialisation profiles, results indicated that ethnic-gender socialisation cluster profiles were directly associated with sexual assertiveness and safer sex behaviour...
September 18, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28919824/strengthening-participation-by-young-women-sex-workers-in-hiv-programs-reflections-on-a-study-from-bangkok-thailand
#5
Cath Conn, Kristel Modderman, Shoba Nayar
BACKGROUND: Participation is an accepted means of increasing the effectiveness of public health programs, and as such, it is considered an important component of HIV interventions targeting at-risk youth. The situation of young women sex workers in Thailand is alarming on many fronts, including that of HIV risk. As a result, HIV programs in Thailand are the key interventions undertaken in relation to young women sex workers' health. A small-scale study used semistructured interviews to explore the participation reports of five young women sex workers, as well as the related views of two community support workers, who lived and worked in Bangkok, Thailand...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28918126/high-cmv-igg-antibody-levels-are-associated-to-a-lower-cd4-response-to-antiretroviral-therapy-in-hiv-infected-women
#6
Marina Giuliano, Maria Franca Pirillo, Giuseppe Liotta, Mauro Andreotti, Haswell Jere, Jean-Baptiste Sagno, Fausto Ciccacci, Roberta Amici, Maria Cristina Marazzi, Stefano Vella, Leonardo Palombi, Sandro Mancinelli
BACKGROUND: Virtually all HIV-infected women in sub-Saharan Africa have evidence of Cytomegalovirus (CMV) infection and levels of specific anti-CMV IgG have been suggested to represent more intense reactivation of subclinical infection. Studies have also shown direct influence of CMV on lymphocytes. OBJECTIVE: The aim of this study was to determine if levels of anti-CMV specific antibodies could impact on the immunological response to antiretroviral treatment (ART) in HIV-infected pregnant women...
September 5, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28914169/development-of-an-algorithm-for-determination-of-the-likelihood-of-virological-failure-in-hiv-positive-adults-receiving-antiretroviral-therapy-in-decentralized-care
#7
Anton Reepalu, Taye Tolera Balcha, Sten Skogmar, Per-Erik Isberg, Patrik Medstrand, Per Björkman
BACKGROUND: Early identification of virological failure (VF) limits occurrence and spread of drug-resistant viruses in patients receiving antiretroviral treatment (ART). Viral load (VL) monitoring is therefore recommended, but capacities to comply with this are insufficient in many low-income countries. Clinical algorithms might identify persons at higher likelihood of VF to allocate VL resources. OBJECTIVES: We aimed to construct a VF algorithm (the Viral Load Testing Criteria; VLTC) and compare its performance to the 2013 WHO treatment failure criteria...
2017: Global Health Action
https://www.readbyqxmd.com/read/28904453/hospital-based-retrospective-study-of-cryptococcal-meningitis-in-a-large-cohort-from-india
#8
Karkal Ravishankar Naik, Aralikatte Onkarappa Saroja, Darshan Kiran Doshi
BACKGROUND: Cryptococcal meningitis is an important and a fatal neuroinfection. Early diagnosis and treatment is of utmost importance in reducing morbidity and mortality. MATERIALS AND METHODS: Data of patients with laboratory-confirmed cryptococcal meningitis seen in tertiary care hospital were reviewed. Details of demographic profile, clinical data, laboratory parameters, complications, and in-hospital mortality were studied. RESULTS: Among 97 patients with cryptococcal meningitis (79 men, 18 women), 88 were HIV-positive, two were diabetic, and seven were sporadic...
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28903576/mitigating-intimate-partner-violence-among-south-african-women-testing-hiv-positive-during-mobile-counseling-and-testing
#9
L Lauren Brown, Michiel A Riaan Van Zyl
South African women continue to suffer disproportionately from the interlinked epidemics of HIV and intimate partner violence (IPV). Effective strategies are needed to mitigate HIV-related IPV, which often creates barriers to successful engagement along the HIV continuum of care. More information is needed on how IPV impacts women's safety following mobile HCT diagnosis, and the HIV IPV Risk Assessment & Safety-planning (HIRS) protocol was developed to address several related gaps in knowledge. The sample included 255 black South African women experiencing IPV and testing HIV+ during mobile HCT in Gauteng province...
September 13, 2017: AIDS Care
https://www.readbyqxmd.com/read/28902073/cryotherapy-reduces-progression-of-cervical-intraepithelial-neoplasia-grade-1-in-south-african-hiv-infected-women-a-randomized-controlled-trial
#10
Cynthia Firnhaber, Avril Swarts, Bridgette Goeieman, Ntombi Rakhombe, Masangu Mulongo, Anna-Lise Williamson, Pam Michelow, Sibongile Ramotshela, Mark Faesen, Simon Levin, Timothy Wilkin
BACKGROUND: HIV-infected women are at increased risk of cervical cancer, especially in resource-limited countries. Cervical cancer prevention strategies focus treating cervical high-grade squamous intraepithelial lesions (HSIL). The management of low-grade squamous intraepithelial lesions (LSIL) in HIV-infected women is unknown. SETTING: HIV treatment clinic in Johannesburg, South Africa METHODS:: We randomized HIV-infected women with histologic cervical LSIL to cervical cryotherapy vs...
September 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28900756/systematic-review-of-interventions-for-depression-for-people-living-with-hiv-in-africa
#11
REVIEW
Sarah M Lofgren, Noeline Nakasujja, David R Boulware
Depression interventions for individuals with HIV/AIDS in Africa are being increasingly evaluated. MEDLINE was searched using key terms: depression, Africa, and HIV, to identify depression interventions for HIV-infected adults in Africa. Perinatal women were excluded. Results were extracted and relative change in depression scores for interventions and net effect calculated. The MEDLINE search yielded 18 articles. Six of seven studies evaluating feasibility were positive, and seven of seven studies evaluating acceptability were also positive...
September 12, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28893207/hepatitis-b-virus-and-hiv-co-infection-among-pregnant-women-in-rwanda
#12
Mwumvaneza Mutagoma, Helene Balisanga, Samuel S Malamba, Dieudonné Sebuhoro, Eric Remera, David J Riedel, Steve Kanters, Sabin Nsanzimana
BACKGROUND: Hepatitis B virus (HBV) affects people worldwide but the local burden especially in pregnant women and their new born babies is unknown. In Rwanda HIV-infected individuals who are also infected with HBV are supposed to be initiated on ART immediately. HBV is easily transmitted from mother to child during delivery. We sought to estimate the prevalence of chronic HBV infection among pregnant women attending ante-natal clinic (ANC) in Rwanda and to determine factors associated with HBV and HIV co-infection...
September 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28886165/low-mother-to-child-hiv-transmission-rate-but-high-loss-to-follow-up-among-mothers-and-babies-in-mandalay-myanmar-a-cohort-study
#13
Khine Wut Yee Kyaw, Myo Minn Oo, Nang Thu Thu Kyaw, Khaing Hnin Phyo, Thet Ko Aung, Theingi Mya, Nilar Aung, Htun Nyunt Oo, Petros Isaakidis
INTRODUCTION: Loss-to-follow-up (LTFU) throughout the Prevention of Mother-To-Child Transmission (PMTCT) cascade remains one of the major threats to the success of PMTCT programs. In this study, we aimed to determine the mother-to-child transmission rate in a programmatic setting and to determine factors associated with LTFU among enrolled mothers and unfavorable outcomes among HIV-exposed babies which includes being HIV positive, death and LTFU. METHODS: A retrospective cohort study reviewing routinely collected data in an Integrated HIV care program, Mandalay, Myanmar in June 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28884524/hiv-transmission-and-retention-in-care-among-hiv-exposed-children-enrolled-in-malawi-s-prevention-of-mother-to-child-transmission-programme
#14
Andreas D Haas, Joep J van Oosterhout, Lyson Tenthani, Andreas Jahn, Marcel Zwahlen, Malango T Msukwa, Mary-Ann Davies, Kali Tal, Nozgechi Phiri, Adrian Spoerri, Frank Chimbwandira, Matthias Egger, Olivia Keiser
INTRODUCTION: In Malawi, HIV-infected pregnant and breastfeeding women are offered lifelong antiretroviral therapy (ART) regardless of CD4 count or clinical stage (Option B+). Their HIV-exposed children are enrolled in the national prevention of mother-to-child transmission (PMTCT) programme, but many are lost to follow-up. We estimated the cumulative incidence of vertical HIV transmission, taking loss to follow-up into account. METHODS: We abstracted data from HIV-exposed children enrolled into care between September 2011 and June 2014 from patient records at 21 health facilities in central and southern Malawi...
September 4, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28882911/predictors-of-hiv-virological-failure-and-drug-resistance-in-chinese-patients-after-48-months-of-antiretroviral-treatment-2008-2012-a-prospective-cohort-study
#15
Wei Kan, Tao Teng, Shujia Liang, Yanling Ma, Heng Tang, Tuerdi Zuohela, Guoqing Sun, Cui He, Kristin M Wall, Vincent C Marconi, Lingjie Liao, Xuebing Leng, Pengtao Liu, Yuhua Ruan, Hui Xing, Yiming Shao
OBJECTIVE: To explore factors associated with HIV virological failure (VF) and HIV drug resistance (HIVDR) among HIV-positive Chinese individuals 4 years after initiating first-line lamivudine-based antiretroviral treatment (ART) in 2008 at five sentinel sites. DESIGN: First-line ART initiators who were previously treatment naïve were selected using consecutive ID numbers from the 2008 National Surveillance Database into a prospective cohort study. Questionnaires and blood samples were collected in 2011 and 2012 to assess the outcomes of interest: VF (defined as viral load ≥1000 copies/mL) and HIVDR (defined as VF with genetic drug-resistant mutations)...
September 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28882163/prevalence-and-significance-of-mycoplasma-genitalium-in-women-living-with-hiv-in-denmark
#16
Anne Marie Rosendahl Madsen, Kristina Thorsteinsson, Anne-Mette Lebech, Merete Storgaard, Terese L Katzenstein, Frederikke F Rönsholt, Isik Somuncu Johansen, Gitte Pedersen, Lars Noerregaard Nielsen, Aase Bengaard Andersen, Jørgen Skov Jensen
OBJECTIVE: Mycoplasma genitalium (M. genitalium) is a sexually transmitted pathogen associated with urethritis, cervicitis, and pelvic inflammatory disease. Previous studies have shown a strong association between M. genitalium and HIV infection, therefore screening and treatment for M. genitalium has been suggested as part of HIV prevention strategies. The objective of this study was to determine the prevalence of M. genitalium in women living with HIV (WLWH) in Denmark, and to compare the result with data on symptoms from the lower abdomen, sexual habits and immune status...
September 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28882073/qualitative-research-methods-to-advance-research-on-health-inequities-among-previously-incarcerated-women-living-with-hiv-in-alabama
#17
Courtenay Sprague, Michael L Scanlon, David W Pantalone
Justice-involved HIV-positive women have poor health outcomes that constitute health inequities. Researchers have yet to embrace the range of qualitative methods to elucidate how psychosocial histories are connected to pathways of vulnerability to HIV and incarceration for this key population. We used life course narratives and intersubjectivity-predicated on interview dialogue-to investigate how familial and social settings established their social patterning of HIV, incarceration risk, and poor health. Working with two Alabama community-based organizations, we recruited and interviewed 24 HIV-positive cisgender women with cyclical incarceration...
September 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28881318/alcohol-and-substance-use-diagnoses-among-hiv-positive-patients-receiving-care-in-nyc-clinic-settings
#18
Sitaji Gurung, Ana Ventuneac, Demetria Cain, Chloe Mirzayi, Christopher Ferraris, H Jonathon Rendina, Martha A Sparks, Jeffrey T Parsons
BACKGROUND: Substance use among HIV-positive persons exacerbates health problems. This study sought to estimate the prevalence of alcohol and drug-use diagnoses and examined hypothesized predictors associated with alcohol and drug-use diagnoses among HIV-positive patients in New York City (NYC). METHODS: This cohort study reviewed electronic medical records (EMRs) of 4965 HIV-positive patients based on diagnostic codes. These patients attended a comprehensive care clinic in NYC in 2012...
August 24, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28880995/vitamin-a-supplements-for-reducing-mother-to-child-hiv-transmission
#19
REVIEW
Charles S Wiysonge, Valantine N Ndze, Eugene J Kongnyuy, Muki S Shey
BACKGROUND: Strategies to reduce the risk of mother-to-child transmission of the human immunodeficiency virus (HIV) include lifelong antiretroviral therapy (ART) for HIV-positive women, exclusive breastfeeding from birth for six weeks plus nevirapine or replacement feeding plus nevirapine from birth for four to six weeks, elective Caesarean section delivery, and avoiding giving children chewed food. In some settings, these interventions may not be practical, feasible, or affordable. Simple, inexpensive, and effective interventions (that could potentially be implemented even in the absence of prenatal HIV testing programmes) would be valuable...
September 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28880892/beyond-hiv-serodiscordance-partnership-communication-dynamics-that-affect-engagement-in-safer-conception-care
#20
Lynn T Matthews, Bridget F Burns, Francis Bajunirwe, Jerome Kabakyenga, Mwebesa Bwana, Courtney Ng, Jasmine Kastner, Annet Kembabazi, Naomi Sanyu, Adrine Kusasira, Jessica E Haberer, David R Bangsberg, Angela Kaida
INTRODUCTION: We explored acceptability and feasibility of safer conception methods among HIV-affected couples in Uganda. METHODS: We recruited HIV-positive men and women on antiretroviral therapy (ART) ('index') from the Uganda Antiretroviral Rural Treatment Outcomes cohort who reported an HIV-negative or unknown-serostatus partner ('partner'), HIV-serostatus disclosure to partner, and personal or partner desire for a child within two years. We conducted in-depth interviews with 40 individuals from 20 couples, using a narrative approach with tailored images to assess acceptability of five safer conception strategies: ART for the infected partner, pre-exposure prophylaxis (PrEP) for the uninfected partner, condomless sex timed to peak fertility, manual insemination, and male circumcision...
2017: PloS One
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