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https://www.readbyqxmd.com/read/28334399/association-of-hiv-status-with-local-immune-response-to-anal-squamous-cell-carcinoma-implications-for-immunotherapy
#1
Elizabeth L Yanik, Genevieve J Kaunitz, Tricia R Cottrell, Farah Succaria, Tracee L McMiller, Maria L Ascierto, Jessica Esandrio, Haiying Xu, Aleksandra Ogurtsova, Toby Cornish, Evan J Lipson, Suzanne L Topalian, Eric A Engels, Janis M Taube
Importance: The programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) pathway play an important immunosuppressive role in cancer and chronic viral infection, and have been effectively targeted in cancer therapy. Anal squamous cell carcinoma (SCC) is associated with both human papillomavirus and HIV infection. To date, patients with HIV have been excluded from most trials of immune checkpoint blocking agents, such as anti-PD-1 and anti-PD-L1, because it was assumed that their antitumor immunity was compromised compared with immunocompetent patients...
March 23, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28331250/sexual-behavior-hiv-prevalence-and-awareness-among-wives-of-migrant-workers-results-from-cross-sectional-survey-in-rural-north-india
#2
Alok Ranjan, Tarun Bhatnagar, Giridhara R Babu, Roger Detels
BACKGROUND: Migration has been linked to the spread of HIV epidemic from the urban areas of western India to the rural areas of north India. OBJECTIVES: This is the first population-based study among the wives of migrant workers of Muzaffarpur district in Bihar with objectives to describe their sexual behavior within marriage, estimate the prevalence of HIV, and to know their awareness regarding HIV/AIDS. METHODS: A two-stage cluster survey was conducted by randomly selecting 25 eligible wives from each of the 34 selected villages...
January 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/28329940/-effectiveness-of-prevention-of-mother-to-child-hiv-transmission-in-henan-province-2002-2013
#3
Q Wang, D Y Sun, P Y Fan, Y M Ma, N Ma, H Si, N Li, Z Wang
Objective: To evaluate the effectiveness of the intervention on preventing mother to child transmission of HIV and identify the influencing factors. Methods: The data regarding the pregnant women and their infants were collected, including demographic characteristics, pregnancy and delivery, access to antiviral therapy, HIV infection status at age 18 months and survival of infants between 2002 and 2013 through follow-up, Multivariate logistic regression model were used to identify the influencing factors. Results: By the end of 2013, a total of 8 621 554 pregnant women received HIV test, among them 2 264 were infected with HIV...
March 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28323758/cervical-cancer-screening-intervals-and-management-for-women-living-with-hiv-a-risk-benchmarking-approach
#4
Hilary A Robbins, Howard D Strickler, L Stewart Massad, Christopher B Pierce, Teresa M Darragh, Howard Minkoff, Marla J Keller, Margaret Fischl, Joel Palefsky, Lisa Flowers, Lisa Rahangdale, Joel Milam, Sadeep Shrestha, Christine Colie, Gypsyamber Dʼsouza
OBJECTIVE: We suggested cervical cancer screening strategies for women living with HIV (WLHIV) by comparing their precancer risks to general population women, and then compared our suggestions to current CDC guidelines. DESIGN: We compared risks of biopsy-confirmed cervical high-grade squamous intraepithelial neoplasia or worse (bHSIL+), calculated among WLHIV in the Women's Interagency HIV Study, to "risk benchmarks" for specific management strategies in the general population...
March 18, 2017: AIDS
https://www.readbyqxmd.com/read/28323754/-it-s-inside-my-body-and-it-s-mine
#5
Elizabeth T Montgomery, Ariane van der Straten, Miria Chitukuta, Krishnaveni Reddy, Kubashni Woeber, Millicent Atujuna, Linda-Gail Bekker, Juliane Etima, Teopista Nakyanzi, Ashley J Mayo, Ariana Katz, Nicole Laborde, Cynthia I Grossman, Lydia Soto-Torres, Thesla Palanee-Phillips, Jared M Baeten
The MTN-020/ASPIRE trial evaluated the safety and effectiveness of the dapivirine vaginal ring for prevention of HIV-1 infection among African women. A nested qualitative component was conducted at 6 of 15 study sites in Uganda, Malawi, Zimbabwe and South Africa to evaluate acceptability of and adherence to the ring. Qualitative study participants (n = 214) were interviewed with one of 3 modalities: single in-depth interview, up to 3 serial interviews, or an exit Focus Group Discussion. Using semi-structured guides administered in local languages, 280 interviews were audio-recorded, transcribed, translated, coded and analyzed...
March 18, 2017: AIDS
https://www.readbyqxmd.com/read/28320431/barriers-to-uptake-of-early-infant-hiv-testing-in-zambia-the-role-of-intimate-partner-violence-and-hiv-status-disclosure-within-couples
#6
Karen M Hampanda, Abigail M Nimz, Lisa L Abuogi
BACKGROUND: Early detection of pediatric HIV through uptake of infant HIV testing is critical for access to treatment and child survival. While structural barriers have been well described, a greater understanding of social and behavioral factors that may relate to maternal uptake of early infant HIV testing services is urgently needed. The aim of this study was to explore how gender power dynamics within couples affect HIV-positive women's uptake of early infant HIV testing at a large health center in Lusaka, Zambia...
March 21, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28320347/facilitators-and-barriers-to-uptake-and-adherence-to-lifelong-antiretroviral-therapy-among-hiv-infected-pregnant-women-in-uganda-a-qualitative-study
#7
Esther Buregyeya, Rose Naigino, Aggrey Mukose, Fred Makumbi, Godfrey Esiru, Jim Arinaitwe, Joshua Musinguzi, Rhoda K Wanyenze
BACKGROUND: In 2012, Uganda started implementing lifelong antiretroviral therapy (ART) for prevention of mother to child transmission (PMTCT) in line with the WHO 2012 guidelines. This study explored experiences of HIV infected pregnant and breastfeeding women regarding barriers and facilitators to uptake and adherence to lifelong ART. METHODS: This was a cross-sectional qualitative study conducted in three districts (Masaka, Mityana and Luwero) in Uganda, between February and May 2014...
March 21, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28317804/a-survey-on-undiagnosed-active-pulmonary-tuberculosis-among-pregnant-mothers-in-mekelle-and-surrounding-districts-in-tigray-ethiopia
#8
Dawit Gebreegziabiher, Kelemework Adane, Markos Abebe
OBJECTIVE/BACKGROUND: To determine the prevalence of undiagnosed active pulmonary tuberculosis (PTB) cases and sensitivity, specificity, and positive and negative predictive values of symptom combinations for undiagnosed TB infection in human immunodeficiency virus (HIV)-positive and HIV-negative pregnant mothers attending antenatal care (ANC) clinics. Mycobacterium TB and HIV are the leading causes of death among women of reproductive age worldwide. Symptom screening is the first step in the World Health Organization (WHO)-recommended TB intensified case finding algorithm for people living with HIV...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28317511/randomized-study-of-assessment-effects-on-alcohol-use-by-persons-with-hiv-in-rural-uganda
#9
Nneka I Emenyonu, Robin Fatch, Winnie R Muyindike, Allen Kekibiina, Sarah Woolf-King, Judith A Hahn
OBJECTIVE: Unhealthy alcohol use is a crucial driver of HIV in sub-Saharan Africa, and interventions are needed. The goal of this study was to assess whether assessment itself (assessment reactivity) causes declines in alcohol use in a research study in persons with HIV in Uganda. METHOD: Study participants were adult patients of the Immune Suppression Syndrome (ISS) Clinic in Mbarara, Uganda, who were new to HIV care and reported any alcohol consumption in the prior year...
March 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28315082/caregivers-support-network-characteristics-associated-with-viral-suppression-among-hiv-care-recipients
#10
Julie A Denison, Mary M Mitchell, Allysha C Maragh-Bass, Amy R Knowlton
Informal care receipt is associated with health outcomes among people living with HIV. Less is known about how caregivers' own social support may affect their care recipient's health. We examined associations between network characteristics of informal caregivers and HIV viral suppression among former or current drug using care recipients. We analyzed data from 258 caregiver-recipient dyads from the Beacon study, of whom 89% of caregivers were African American and 59% were female. In adjusted logistic regression analysis, care recipients had lower odds of being virally suppressed if their caregiver was female, was caring for youth involved in the criminal justice system, and had network members who used illicit drugs...
March 17, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28304326/group-b-streptococcus-colonization-and-hiv-in-pregnancy-a-cohort-study-in-nigeria
#11
R Biobaku Oluwafunmilola, O Olaleye Atinukek, F Adefusi Olorunwa, A Adeyemi Babalola, O Onipede Anthony, M Loto Olabisi, O Imaralu John
BACKGROUND: Group B streptococcus (GBS) is a leading cause of maternal and neonatal infectious morbidity. HIV is prevalent among pregnant women in Nigeria. AIM: To determine the rates of anogenital GBS colonization in our institution and compare GBS colonization rates between HIV positive and negative pregnant women. METHODS: A cross-sectional comparative study was conducted over 6 months. Patients were separated according to their HIV status: positive and negative...
March 16, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28303199/hiv-aids-in-the-south-east-asia-region-progress-and-challenges
#12
EDITORIAL
Razia Pendse, Somya Gupta, Dongbao Yu, Swarup Sarkar
The South-East Asia region, with 11 member states, has an estimated 3.5 million people living with HIV (PLHIV). More than 99% of PLHIV live in five countries where HIV prevalence among the population aged 15-49 remains low but is between 2% and 29% among key populations. Since 2010, the region has made progress to combat the epidemic. Mature condom programmes exist in most countries but opioid substitution therapy, and needle and syringe exchange programmes need to be scaled up. HIV testing is recommended nationwide in four countries and is prioritised in high prevalence areas or for key populations in the rest...
November 28, 2016: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28299518/addressing-the-first-90-a-highly-effective-partner-notification-approach-reaches-previously-undiagnosed-sexual-partners-in-tanzania
#13
Catherine Kahabuka, Marya Plotkin, Alice Christensen, Charlene Brown, Mustafa Njozi, Renatus Kisendi, Werner Maokola, Erick Mlanga, Ruth Lemwayi, Kelly Curran, Vincent Wong
To meet UNAIDS' 90-90-90 treatment goals, effective approaches to HIV testing services (HTSs) are urgently needed. In 2015, a cross-sectional study was conducted to evaluate effectiveness and feasibility of partner notification for HTS in Tanzania. Men and women newly diagnosed with HIV were enrolled as index clients, listed sexual partners, and given options to notify and link their partners to HTS. Of 653 newly diagnosed individuals, 390 index clients were enrolled, listed 438 sexual partners, of whom 249 (56...
March 15, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28296802/the-effects-of-hiv-on-fertility-by-infection-duration-evidence-from-african-population-cohorts-before-antiretroviral-treatment-availability
#14
Milly Marston, Jessica Nakiyingi-Miiro, Sylvia Kusemererwa, Mark Urassa, Denna Michael, Constance Nyamukapa, Simon Gregson, Basia Zaba, Jeffrey W Eaton
OBJECTIVES: To estimate the relationship between HIV natural history and fertility by duration of infection in east and southern Africa before the availability of antiretroviral therapy and assess potential biases in estimates of age-specific subfertility when using retrospective birth histories in cross-sectional studies. DESIGN: Pooled analysis of prospective population-based HIV cohort studies in Masaka (Uganda), Kisesa (Tanzania) and Manicaland (Zimbabwe). METHODS: Women aged 15-49 years who had ever tested for HIV were included...
April 2017: AIDS
https://www.readbyqxmd.com/read/28296240/hiv-positive-malawian-women-with-young-children-prefer-overweight-body-sizes-and-link-underweight-body-size-with-inability-to-exclusively-breastfeed
#15
Samantha E Croffut, Gloria Hamela, Innocent Mofolo, Suzanne Maman, Mina C Hosseinipour, Irving F Hoffman, Margaret E Bentley, Valerie L Flax
Before the prevention of mother-to-child transmission (PMTCT) program was widely implemented in Malawi, HIV-positive women associated exclusive breastfeeding with accelerated disease progression and felt that an HIV-positive woman could more successfully breastfeed if she had a larger body size. The relationship between breastfeeding practices and body image perceptions has not been explored in the context of the Option B+ PMTCT program, which offers lifelong antiretroviral therapy. We conducted in-depth interviews with 64 HIV-positive women in Lilongwe District, Malawi to investigate body size perceptions, how perceptions of HIV and body size influence infant feeding practices, and differences in perceptions among women in PMTCT and those lost to follow-up...
March 10, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28291302/psychosocial-group-interventions-to-improve-psychological-well-being-in-adults-living-with-hiv
#16
REVIEW
Ingrid van der Heijden, Naeemah Abrahams, David Sinclair
BACKGROUND: Being diagnosed with human immunodeficiency virus (HIV), and labelled with a chronic, life-threatening, and often stigmatizing disease, can impact on a person's well-being. Psychosocial group interventions aim to improve life-functioning and coping as individuals adjust to the diagnosis. OBJECTIVES: To examine the effectiveness of psychosocial group interventions for improving the psychological well-being of adults living with HIV/AIDS. SEARCH METHODS: We searched the following electronic databases up to 14 March 2016: the Cochrane Central Register of Controlled Trials (CENTRAL) published in the Cochrane Library (Issue 2, 2016), PubMed (MEDLINE) (1996 to 14 March 2016), Embase (1996 to 14 March 2016), and Clinical Trials...
March 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28288159/determinants-of-anemia-among-pregnant-mothers-attending-antenatal-care-in-dessie-town-health-facilities-northern-central-ethiopia-unmatched-case-control-study
#17
Sisay Eshete Tadesse, Omer Seid, Yemane G/Mariam, Abel Fekadu, Yitbarek Wasihun, Kedir Endris, Abebayehu Bitew
INTRODUCTION: Anemia affects around 38.2% and 22% of pregnant women at a global and national level respectively. In developing countries, women start pregnancy with already depleted body stores of iron and other vitamins with significant variation of anemia within and between regions. OBJECTIVE: To identify the determinants of anemia among pregnant mothers attending antenatal care in Dessie town health facilities, northern central Ethiopia. METHODS: A health facility based unmatched case control study was conducted among 112 cases and 336 controls from January to March 2016 G...
2017: PloS One
https://www.readbyqxmd.com/read/28286719/violence-exclusion-and-resilience-among-ivoirian-travestis
#18
Matthew Thomann, Robbie Corey-Boulet
Among sexual and gender minorities in Côte d'Ivoire, travestis are defined as individuals born anatomically male who live as women on a full- or part-time basis. Travestis encounter harsher stigmatization and violence than sexual minorities whose gender normativity allows them to avoid unwanted attention. Moreover, they have traditionally been underserved by Ivoirian sexual minority rights groups, who have worked to distance themselves from travestis, framing them as recklessly indiscreet. In this paper, we examine the extent to which travestis' isolation has lessened in the wake of the post-election violence that followed Côte d'Ivoire's 2010 presidential election...
2017: Crit Afr Stud
https://www.readbyqxmd.com/read/28285796/cardiovascular-disease-in-women-with-hiv-1-infection
#19
Massimo Volpe, Alessia Uglietti, Antonella Castagna, Cristina Mussini, Giulia Marchetti, Rita Bellagamba, Teresa Bini, Daniela Mancusi, Roberta Termini
Cardiovascular disease is a leading cause of death in women, nevertheless it is often underestimated in female patients without overt risk factors. The chronic infection by Human Immunodeficiency Virus (HIV) is clearly associated, along with the use of certain antiretroviral drugs and traditional risk factors, with an increased risk of cardiovascular diseases. The aim of this manuscript is to review the epidemiology, risk factors, pathogenesis, diagnostic approach, primary and secondary prevention strategies of cardiovascular disease in HIV-negative and HIV-positive female subjects...
February 27, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28285153/contraceptive-method-and-self-reported-hiv-status-among-women-in-malawi
#20
Jamie E Luster, Abigail Norris Turner, Duna Alkhalaileh, Maria F Gallo
OBJECTIVES: We aimed to describe contraceptive methods used by women in Malawi and determine whether contraceptive use differed by self-reported HIV status. Effective contraception is a primary method of preventing mother-to-child transmission of HIV. STUDY DESIGN: Analysis is based on 12,658 nonpregnant, sexually debuted women ages 15-49 years in the 2010 Malawi Demographic and Health Survey. Analysis was restricted to respondents with contraceptive need (i.e., fecund and did not want a child in the next 12 months) who reported their last HIV test result...
March 8, 2017: Contraception
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