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https://www.readbyqxmd.com/read/29164754/interventions-to-significantly-improve-service-uptake-and-retention-of-hiv-positive-pregnant-women-and-hiv-exposed-infants-along-the-pmtct-continuum-of-care-systematic-review
#1
REVIEW
Alexandra C Vrazo, Jacqueline Firth, Anouk Amzel, Rebecca Sedillo, Julia Ryan, B Ryan Phelps
OBJECTIVES: Despite the success of Prevention of Mother-to-Child Transmission of HIV (PMTCT) programs, low uptake of services and poor retention pose a formidable challenge to achieving the elimination of vertical HIV transmission in low and middle-income countries. This systematic review summarizes interventions that demonstrate statistically significant improvements in service uptake and retention of HIV-positive pregnant and breastfeeding women and their infants along the PMTCT cascade...
November 22, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29162570/relationship-between-socioeconomic-status-and-hiv-infection-findings-from-a-survey-in-the-free-state-and-western-cape-provinces-of-south-africa
#2
Erick Wekesa Bunyasi, David John Coetzee
BACKGROUND: Studies have shown a mixed association between socioeconomic status (SES) and prevalent HIV infection across and within settings in sub-Saharan Africa. In general, the relationship between years of formal education and HIV infection changed from a positive to a negative association with maturity of the HIV epidemic. Our objective was to determine the association between SES and HIV in women of reproductive age in the Free State (FSP) and Western Cape Provinces (WCP) of South Africa (SA)...
November 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/29161256/hiv-pre-exposure-prophylaxis-and-early-antiretroviral-treatment-among-female-sex-workers-in-south-africa-results-from-a-prospective-observational-demonstration-project
#3
Robyn Eakle, Gabriela B Gomez, Niven Naicker, Rutendo Bothma, Judie Mbogua, Maria A Cabrera Escobar, Elaine Saayman, Michelle Moorhouse, W D Francois Venter, Helen Rees
BACKGROUND: Operational research is required to design delivery of pre-exposure prophylaxis (PrEP) and early antiretroviral treatment (ART). This paper presents the primary analysis of programmatic data, as well as demographic, behavioural, and clinical data, from the TAPS Demonstration Project, which offered both interventions to female sex workers (FSWs) at 2 urban clinic sites in South Africa. METHODS AND FINDINGS: The TAPS study was conducted between 30 March 2015 and 30 June 2017, with the enrolment period ending on 31 July 2016...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29159861/promoting-high-standards-of-care-for-women-living-with-hiv-position-statement-from-the-women-against-viruses-in-europe-working-group
#4
J D Kowalska, K Aebi-Popp, M Loutfy, F A Post, M J Perez-Elias, M Johnson, F Mulcahy
OBJECTIVES: Gender-related factors can influence management decisions, treatment outcomes and the overall long-term wellbeing of people living with HIV (PLWH). The Women Against Viruses in Europe (WAVE) Working Group was established to promote the health and wellbeing of women living with HIV (WLWH). WAVE is part of the European AIDS Clinical Society (EACS) and organizes annual workshops to discuss different issues in the management of WLWH. METHODS: In 2016, 34 WAVE members including community representatives, HIV clinicians and researchers met to discuss standards of care for WLWH and to review current guidelines...
November 21, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29159592/uptake-of-a-partner-notification-model-for-hiv-among-men-who-have-sex-with-men-and-transgender-women-in-tijuana-mexico
#5
Shirley J Semple, Heather A Pines, Steffanie A Strathdee, Alicia Harvey Vera, Gudelia Rangel, Carlos Magis-Rodriguez, Thomas L Patterson
Undiagnosed HIV infection is common among men who have sex with men (MSM) and transgender women (TW) in Latin America. We examined uptake of a partner notification (PN) model among MSM and TW in Tijuana, Mexico. Forty-six HIV-positive MSM/TW enrolled as index patients, and reported 132 MSM/TW sexual partners for PN. Of notified partners (90/132), 39% declined eligibility screening or participation, 39% tested for HIV, and of those 28% were newly-diagnosed HIV-positive. Partners who were seen by the index patient more than once in the past 4 months and those who primarily had sex with the index patient in one of their homes were more likely to be notified via PN (76% vs...
November 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29159414/hepatitis-b-vaccination-screening-and-linkage-to-care-best-practice-advice-from-the-american-college-of-physicians-and-the-centers-for-disease-control-and-prevention
#6
Winston E Abara, Amir Qaseem, Sarah Schillie, Brian J McMahon, Aaron M Harris
Background: Vaccination, screening, and linkage to care can reduce the burden of chronic hepatitis B virus (HBV) infection. However, recommendations vary among organizations, and their implementation has been suboptimal. The American College of Physicians' High Value Care Task Force and the Centers for Disease Control and Prevention developed this article to present best practice statements for hepatitis B vaccination, screening, and linkage to care. Methods: A narrative literature review of clinical guidelines, systematic reviews, randomized trials, and intervention studies on hepatitis B vaccination, screening, and linkage to care published between January 2005 and June 2017 was conducted...
November 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29158723/the-usefulness-of-traditional-birth-attendants-to-women-living-with-hiv-in-resource-poor-settings-the-case-of-mfuwe-zambia
#7
Choolwe Muzyamba, Wim Groot, Sonila M Tomini, Milena Pavlova
Background: Although there is increased attention on the role of trained traditional birth attendants (TBAs) in maternal care, most of the research has mainly focused on providing evidence of the relevance of trained TBAs to women in general without a specific focus on women who are HIV positive, despite them being most vulnerable. Therefore, the aim of this study is to fill this gap by assessing the relevance of trained TBAs to women living with HIV in resource-poor settings by using Zambia as a case study...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29158102/human-papillomavirus-types-from-infection-to-cancer-in-the-anus-according-to-sex-and-hiv-status-a-systematic-review-and-meta-analysis
#8
Chunqing Lin, Silvia Franceschi, Gary M Clifford
BACKGROUND: Data on carcinogenicity of human papillomavirus (HPV) types in the anus are needed to inform anal cancer prevention through vaccination and screening. This is particularly the case for people infected with HIV, who are at an increased risk of anal cancer. METHODS: We did a systematic review of studies published from January, 1986, to July, 2017, in MEDLINE, Embase, and the Cochrane Library on anal HPV infection, without any language restrictions. Eligible studies reported type-specific HPV prevalence by strata of cytopathological or histopathological anal diagnosis, sex, and HIV status...
November 17, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29153541/screening-for-cervical-cancer-among-hiv-positive-and-hiv-negative-women-in-cameroon-using-simultaneous-co-testing-with-carehpv-dna-testing-and-visual-inspection-enhanced-by-digital-cervicography-findings-of-initial-screening-and-one-year-follow-up
#9
Preetam Cholli, Leslie Bradford, Simon Manga, Kathleen Nulah, Edith Kiyang, Florence Manjuh, Geneva DeGregorio, Rebecca K Ogembo, Enow Orock, Yuxin Liu, Richard G Wamai, Lisa Kennedy Sheldon, Philimon N Gona, Zacharie Sando, Thomas Welty, Edith Welty, Javier Gordon Ogembo
OBJECTIVE: The World Health Organization (WHO)'s cervical cancer screening guidelines for limited-resource settings recommend sequential screening followed by same-day treatment under a "screen-and-treat" approach. We aimed to (1) assess feasibility and clinical outcomes of screening HIV-positive and HIV-negative Cameroonian women by pairing visual inspection with acetic acid and Lugol's iodine enhanced by digital cervicography (VIA/VILI-DC) with careHPV, a high-risk human papillomavirus (HR-HPV) nucleic acid test designed for low-resource settings; and (2) determine persistence of HR-HPV infection after one-year follow-up to inform optimal screening, treatment, and follow-up algorithms...
November 15, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29151197/impact-of-the-dapivirine-vaginal-ring-on-sexual-experiences-and-intimate-partnerships-of-women-in-an-hiv-prevention-clinical-trial-managing-ring-detection-and-hot-sex
#10
Nicole D Laborde, Elizabeth Pleasants, Krishnaveni Reddy, Millicent Atujuna, Teopista Nakyanzi, Miria Chitukuta, Sarita Naidoo, Thesla Palanee-Phillips, Jared M Baeten, Elizabeth T Montgomery
Vaginally-inserted HIV prevention methods have been reported to impact the sexual experience for women and their partners, and hence impacts acceptability of and adherence to the method. We analyzed in-depth interviews and focus group discussions about participants' sexual experiences while wearing the ring, collected during the MTN-020/ASPIRE phase 3 safety and effectiveness trial of a dapivirine vaginal ring for HIV prevention in Malawi, South Africa, Uganda, and Zimbabwe. Most women reported that partners did not feel the ring during sex, however, women felt they had to manage their partners' interaction with or reaction to the ring...
November 18, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29149194/understanding-linkage-to-care-with-hiv-self-test-approach-in-lusaka-zambia-a-mixed-method-approach
#11
Jenala Chipungu, Samuel Bosomprah, Arianna Zanolini, Harsha Thimurthy, Roma Chilengi, Anjali Sharma, Charles B Holmes
INTRODUCTION: HIV self-testing (HIVST) is a novel approach designed to assist in achieving the goal of at least 90% of the population that learn their HIV status. A self-test user with a positive test is required to visit a clinic to link into HIV care, yet little is known about patient preferences for linkage strategies. We examined the intention to link to care amongst potential HIVST users and the suitability of three linkage to care strategies in Lusaka Province, Zambia. METHODS: We conducted a representative cross sectional survey of 1,617 individuals aged 16-49 years old in Lusaka Province...
2017: PloS One
https://www.readbyqxmd.com/read/29143162/anti-retroviral-status-and-hiv-transmission-risk-behaviors-are-associated-with-age-time-since-diagnosis-and-psychosocial-factors-among-women-living-with-hiv-aids-enrolling-in-the-willow-intervention-at-community-based-organizations
#12
Weston O Williams, Tanesha Griffin, Gary Uhl
Safe sexual behaviors and anti-retroviral use help prevent HIV transmission. In this cross-sectional study, we assessed correlates of anti-retroviral (ART) status and transmission risk (a constructed variable) among a convenience sample of n = 1041 HIV-positive women (pre-intervention) enrolled in an evidence-based intervention at four CBOs. Multinomial logistic regression models were used. Younger women and those diagnosed with HIV in the last 5 years more often reported that they had not been prescribed ART...
November 15, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29140871/hiv-prevalence-and-associated-risk-factors-among-men-who-have-sex-with-men-in-dar-es-salaam-tanzania
#13
Elia John Mmbaga, Kåre Moen, Germana Henry Leyna, Rose Mpembeni, Melkizedeck Thomas Leshabari
INTRODUCTION: Limited studies and differential risk behaviours among men who have sex with men(MSM) in Africa calls for population specific studies. We present results from the largest integrated bio-behavioural survey among MSM in Africa to inform programming. METHODS: This was a cross-sectional study utilizing respondent driven sampling to recruit MSM aged 18 and above. Data on socio-demographic characteristics and HIV-related risks were collected and all participants were tested for HIV, Herpes Simplex Virus Type-2 (HSV-2), Hepatitis-B Virus (HBV) and Syphilis...
November 13, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29138654/syphilis-and-hiv-infections-among-pregnant-women-attending-antenatal-clinics-in-republic-of-congo
#14
Roch Fabien Niama, Nadia Claricelle Loukabou Bongolo, Edith Sophie Bayonne Kombo, Ruth Yengo, Pembe Issamou Mayengue, Etoka-Beka Mandingha Kosso, Igor Louzolo, Lucette Macosso, Ghislain Dzeret, Angélie Serge Patrick Dzabatou Babeaux, Marie-Francke Puruehnce, Henri Joseph Parra
Introduction: HIV and syphilis during pregnancy remain a public health concern especially in developing countries. Pregnant women attending antenatal clinics sites for the first time between September and December 2011 and who accepted to participate in the study were enrolled. The objective was to estimate the syphilis and HIV infection rate in this population. Methods: A study was conducted in 44 selected ANCs from 12 departments (5 urban and 7 rural). Pregnant women who accepted to participate in the study, attending selected sentinel ANCs sites for the first time between September and December 2011 were enrolled...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29136009/early-resumption-of-sexual-activity-following-voluntary-medical-male-circumcision-in-botswana-a-qualitative-study
#15
Jenny H Ledikwe, Nankie M Ramabu, Lisa P Spees, Scott Barnhart, Conrad Ntsuape, Bazghina-Werq Semo, Kathleen E Wirth
Unprotected sexual intercourse after undergoing voluntary medical male circumcision but prior to complete wound healing can lead to major adverse events including HIV acquisition. To better understand perceptions related to early resumption of sex prior to wound healing, 27 focus group discussions were conducted among 238 adult men, women, and community leaders in Botswana. Median age among all participants was 31 years of whom 60% were male and 51% were either employed and receiving salary or self-employed...
2017: PloS One
https://www.readbyqxmd.com/read/29133803/microbial-diversity-of-genital-ulcers-of-hsv-2-seropositive-women
#16
Supriya D Mehta, Ashish K Pradhan, Stefan J Green, Ankur Naqib, Elijah Odoyo-June, Charlotte A Gaydos, Sheila Barry, Alan Landay, Robert C Bailey
We measured the microbial community structure of genital ulcers in women. Swabs from clinically detected ulcers were tested for HSV-2 and Treponema pallidum by polymerase chain reaction (PCR). HSV-2 and T. pallidum were detected by serum antibody testing. Microbial community structure was characterized by high-throughput 16 s rRNA gene amplicon sequencing. Multiple group testing and Elastic net and Lasso regressions identified taxa associated with differences in factors of interest. Among 49 ulcer specimens from 49 HSV-2 seropositive women, by PCR HSV-2 was recovered from 28 (57%) specimens and T...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29132770/-management-of-pregnant-women-with-recurrent-herpes-guidelines-for-clinical-practice-from-the-french-college-of-gynecologists-obstetricians-cngof
#17
O Anselem
OBJECTIVE: To provide guidelines for the management of woman with genital herpes during pregnancy or labor and with known history of genital herpes. METHODS: MedLine and Cochrane Library databases search and review of the main foreign guidelines. RESULTS: Genital herpes ulceration during pregnancy in a woman with history of genital herpes correspond to a recurrence. In this situation, there is no need for virologic confirmation (Grade B). In case of recurrent herpes during pregnancy, antiviral therapy with acyclovir or valacyclovir can be administered but provide low efficiency on duration and severity of symptoms (Grade C)...
November 10, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29131878/association-of-brain-structure-changes-and-cognitive-function-with-combination-antiretroviral-therapy-in-hiv-positive-individuals
#18
Ryan Sanford, Lesley K Fellows, Beau M Ances, D Louis Collins
Importance: Despite the introduction of combination antiretroviral therapy (cART), HIV-associated neurocognitive disorders continue to be a problem for treated HIV-positive individuals. The cause of this impairment remains unclear. Objective: To determine if detectable brain changes occur during a 2-year period in HIV-positive individuals who were aviremic and treated with cART. Design, Setting, and Participants: In this longitudinal case-control study, participants underwent neuroimaging and neuropsychological assessment approximately 2 years apart...
November 13, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29131695/time-since-first-acting-on-same-sex-attraction-and-recreational-drug-use-among-men-who-have-sex-with-men-msm-is-there-an-effect-of-gay-age
#19
Cara E Rice, Sara A Vasilenko, Stephanie T Lanza, John A Davis, Karen S Fields, Melissa Ervin, Abigail Norris Turner
BACKGROUND: Men who have sex with men (MSM) have higher rates of substance use compared to men who have sex with women. Among MSM, drug use is linked to higher-risk sexual behavior and acquisition of HIV and other sexually transmitted infections. OBJECTIVES: We hypothesize that time since first acting on one's same sex attraction, or one's "gay age", could be predictive of drug using behavior. METHODS: We examined this question among 176 MSM, aged 18-35, presenting at a public sexual health clinic...
November 13, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29127534/-test-and-treat-among-women-at-high-risk-for-hiv-infection-in-kampala-uganda-antiretroviral-therapy-initiation-and-associated-factors
#20
Yunia Mayanja, Onesmus Kamacooko, Daniel Bagiire, Gertrude Namale, Pontiano Kaleebu, Janet Seeley
Data on implementation of 'Test and Treat' among key populations in sub-Saharan Africa are still limited. We examined factors associated with prompt antiretroviral therapy/ART (within 1 month of HIV-positive diagnosis or 1 week if pregnant) among 343 women at high risk for HIV infection in Kampala-Uganda, of whom 28% initiated prompt ART. Most (95%) reported paid sex within 3 months prior to enrolment. Multivariable logistic regression was used to determine baseline characteristics associated with prompt ART...
November 10, 2017: AIDS and Behavior
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