keyword
MENU ▼
Read by QxMD icon Read
search

Diabetic neuropathic pain

keyword
https://www.readbyqxmd.com/read/28928602/lncrna-nonratt021972-was-associated-with-neuropathic-pain-scoring-in-patients-with-type-2-diabetes
#1
Wei Yu, Guo-Qing Zhao, Rang-Juan Cao, Zhi-Hua Zhu, Kai Li
BACKGROUND: Long noncoding RNAs were involved in the processes of diabetes. Our study was aimed to explore clinical potential of LncRNA NONRATT021972 in diabetic neuropathic pain and investigate detailed mechanisms. METHODS: 154 patients with type 2 diabetes were enrolled as experimental group paired with control. Patients without diabetes but neuropathy were enrolled to explore exclusive role of LncRNA NONRATT021972 in neuropathy. Real-time PCR and ELISA were performed to examine expression of LncRNA and TNF-α in flood...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/28914336/patterns-of-cutaneous-nerve-fibre-loss-and-regeneration-in-type-2-diabetes-with-painful-and-painless-polyneuropathy
#2
Gidon J Bönhof, Alexander Strom, Sonja Püttgen, Bernd Ringel, Jutta Brüggemann, Kálmán Bódis, Karsten Müssig, Julia Szendroedi, Michael Roden, Dan Ziegler
AIMS/HYPOTHESIS: The determinants and mechanisms of the development of diabetic sensorimotor polyneuropathy as a painful (DSPN+p) or painless (DSPN-p) entity remain unclear. We examined the degree of cutaneous nerve fibre loss and regeneration in individuals with type 2 diabetes with DSPN+p or DSPN-p compared with individuals with recent-onset type 2 diabetes and corresponding healthy volunteers. METHODS: In this cross-sectional study, skin biopsies taken from the distal lateral calf were obtained from individuals with recent-onset type 2 diabetes (n = 32) from the German Diabetes Study, with DSPN+p (n = 34) and DSPN-p (n = 32) from the PROPANE study, and volunteers with normal glucose tolerance (n = 50)...
September 15, 2017: Diabetologia
https://www.readbyqxmd.com/read/28900459/protective-effects-of-bogijetong-decoction-and-its-selected-formula-on-neuropathic-insults-in-streptozotocin-induced-diabetic-animals
#3
Ki-Joong Kim, Uk Namgung, Chung Sik Cho
Bogijetong decoction (BGJTD) is a mixture of herbal formulation which is used in the traditional Korean medicine for the treatment of neuropathic pain caused by diabetes. Here, we investigated the regulatory effects of BGJTD and its reconstituted decoction subgroups on the neuropathic responses in streptozotocin- (STZ-) induced diabetic animals. Be decoction (BeD) was formulated by selecting individual herbal components that induced neurite outgrowth most efficiently in each subgroup. BeD induced the neurite outgrowth in DRG neurons most efficiently among decoction subgroups and downregulated the production of TNF-α from the sciatic nerves in STZ-diabetic animals...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28887250/analysis-of-patients-undergoing-major-lower-extremity-amputation-in-the-vascular-quality-initiative
#4
Joshua Gabel, Brice Jabo, Sheela Patel, Sharon Kiang, Christian Bianchi, Jason Chiriano, Theodore Teruya, Ahmed M Abou-Zamzam
BACKGROUND: Despite an aggressive climate of limb salvage and revascularization, 7% of patients with peripheral artery disease undergo major lower extremity amputation (LEA). The purpose of this study was to describe the current demographics and early outcomes of patients undergoing major LEA in the Vascular Quality Initiative (VQI). METHODS: The VQI amputation registry was reviewed to identify patients who underwent major LEAs. Patient factors, limb characteristics, procedure type, and intraoperative variables were analyzed by level of amputation...
September 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28877402/effects-of-s-38093-an-antagonist-inverse-agonist-of-histamine-h3-receptors-in-models-of-neuropathic-pain-in-rats
#5
T Chaumette, E Chapuy, E Berrocoso, M Llorca-Torralba, L Bravo, J A Mico, M Chalus, A Eschalier, D Ardid, F Marchand, A Sors
BACKGROUND: Histamine H3 receptors are mainly expressed on CNS neurons, particularly along the nociceptive pathways. The potential involvement of these receptors in pain processing has been suggested using H3 receptor inverse agonists. METHODS: The antinociceptive effect of S 38093, a novel inverse agonist of H3 receptors, has been evaluated in several neuropathic pain models in rat and compared with those of gabapentin and pregabalin. RESULTS: While S 38093 did not change vocalization thresholds to paw pressure in healthy rats, it exhibited a significant antihyperalgesic effect in the Streptozocin-induced diabetic (STZ) neuropathy model after acute and chronic administration and, in the chronic constriction injury (CCI) model only after chronic administration, submitted to the paw-pressure test...
September 6, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28858986/sensory-phenotype-and-risk-factors-for-painful-diabetic-neuropathy-a-cross-sectional-observational-study
#6
Jana Raputova, Iva Srotova, Eva Vlckova, Claudia Sommer, Nurcan Uceyler, Frank Birklein, Heike L Rittner, Cora Rebhorn, Blanka Adamova, Ivana Kovalova, Eva Kralickova Nekvapilova, Lucas Forer, Jana Belobradkova, Jindrich Olsovsky, Pavel Weber, Ladislav Dusek, Jiri Jarkovsky, Josef Bednarik
Different sensory profiles in diabetic distal symmetrical sensory-motor polyneuropathy (DSPN) may be associated with pain and the responsiveness to analgesia. We aimed to characterize sensory phenotypes of patients with painful and painless diabetic neuropathy and to assess demographic, clinical, metabolic, and electrophysiological parameters related to the presence of neuropathic pain in a large cohort of well-defined DSPN subjects.This observational cross-sectional multi-center cohort study (performed as part of the ncRNAPain EU consortium) of 232 subjects with non-painful (n=74) and painful (n=158) DSPN associated with diabetes mellitus of type 1 and 2 (median age 63 years, range 21-87 years; 92 women) comprised detailed history taking, laboratory tests, neurological examination, quantitative sensory testing, nerve conduction studies, and neuropathy severity scores...
August 3, 2017: Pain
https://www.readbyqxmd.com/read/28851944/therapeutic-effect-of-human-adipose-derived-stem-cells-and-their-secretome-in-experimental-diabetic-pain
#7
Anna T Brini, Giada Amodeo, Lorena M Ferreira, Anna Milani, Stefania Niada, Giorgia Moschetti, Silvia Franchi, Elisa Borsani, Luigi F Rodella, Alberto E Panerai, Paola Sacerdote
Painful neuropathy is one of the complications of diabetes mellitus that adversely affects patients'quality of life. Pharmacological treatments are not fully satisfactory, and novel approaches needed. In a preclinical mouse model of diabetes the effect of both human mesenchymal stromal cells from adipose tissue (hASC) and their conditioned medium (hASC-CM) was evaluated. Diabetes was induced by streptozotocin. After neuropathic hypersensitivity was established, mice were intravenously injected with either 1 × 10(6) hASC or with CM derived from 2 × 10(6) hASC...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28841868/a-systematic-review-of-the-effectiveness-of-policies-restricting-access-to-pregabalin
#8
Brett R Stacey, Jonathan Liss, Regina Behar, Alesia Sadosky, Bruce Parsons, Elizabeth T Masters, Patrick Hlavacek
BACKGROUND: Formularies often employ restriction policies to reduce pharmacy costs. Pregabalin, an alpha-2-delta ligand, is approved for treatment of fibromyalgia (FM); neuropathic pain (NeP) due to postherpetic neuralgia (PHN), diabetic peripheral neuropathy (pDPN), spinal cord injury; and as adjunct therapy for partial onset seizures. Pregabalin is endorsed as first-line therapy for these indications by several US and EU medical professional societies. However, restriction policies such as prior authorization (PA) and step therapy (ST) often favor less costly generic pain medications over pregabalin...
August 25, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28840511/nanoparticle-encapsulated-emodin-decreases-diabetic-neuropathic-pain-probably-via-a-mechanism-involving-p2x3-receptor-in-the-dorsal-root-ganglia
#9
Lin Li, Xuan Sheng, Shanhong Zhao, Lifang Zou, Xinyao Han, Yingxin Gong, Huilong Yuan, Liran Shi, Lili Guo, Tianyu Jia, Shuangmei Liu, Bing Wu, Zhihua Yi, Hui Liu, Yun Gao, Guilin Li, Guodong Li, Chunping Zhang, Hong Xu, Shangdong Liang
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM). More than 90% of all cases of DM belong to type 2 diabetes mellitus (T2DM). Emodin is the main active component of Radix et rhizoma rhei and has anti-bacterial, anti-viral, anti-ulcerogenic, anti-inflammatory, and anti-cancer effects. Nanoparticle encapsulation of drugs is beneficial for drug targeting and bioavailability as well as for lowering drug toxicity side effects. The aim of this study was to investigate the effects of nanoparticle-encapsulated emodin (nano emodin) on diabetic neuropathic pain (DNP) mediated by the Purin 2X3 (P2X3) receptor in the dorsal root ganglia (DRG)...
August 24, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28837503/therapeutic-potential-for-leukocyte-elastase-in-chronic-pain-states-harboring-a-neuropathic-component
#10
Kiran Kumar Bali, Rohini Kuner
Neuropathic pain is an integral component of several chronic pain conditions and poses a major health problem worldwide. Despite emerging understanding of mechanisms behind neuropathic pain, the available treatment options are still limited in efficacy or associated with side effects, therefore making it necessary to find viable alternatives. In a genetic screen, we recently identified SerpinA3N, a serine protease inhibitor secreted in response to nerve damage by the DRG neurons and we showed that SerpinA3N acts against induction of neuropathic pain by inhibiting the T-cell- and neutrophil-derived protease, leucocyte elastase (LE)...
August 19, 2017: Pain
https://www.readbyqxmd.com/read/28837075/botulinum-toxin-for-the-treatment-of-neuropathic-pain
#11
REVIEW
JungHyun Park, Hue Jung Park
Botulinum toxin (BoNT) has been used as a treatment for excessive muscle stiffness, spasticity, and dystonia. BoNT for approximately 40 years, and has recently been used to treat various types of neuropathic pain. The mechanism by which BoNT acts on neuropathic pain involves inhibiting the release of inflammatory mediators and peripheral neurotransmitters from sensory nerves. Recent journals have demonstrated that BoNT is effective for neuropathic pain, such as postherpetic neuralgia, trigeminal neuralgia, and peripheral neuralgia...
August 24, 2017: Toxins
https://www.readbyqxmd.com/read/28834546/pharmacokinetics-and-safety-of-a-single-oral-dose-of-mirogabalin-in-japanese-subjects-with-varying-degrees-of-renal-impairment
#12
Manabu Kato, Naoyuki Tajima, Takako Shimizu, Masahiro Sugihara, Kenichi Furihata, Kazuhiro Harada, Hitoshi Ishizuka
Mirogabalin (DS-5565) is a novel preferentially selective α2 δ-1 ligand being developed for the treatment of diabetic peripheral neuropathic pain and postherpetic neuralgia. The current multicenter open-label study determined the effect of varying degrees of renal impairment on the pharmacokinetics and safety of a single dose of mirogabalin 5 mg in Japanese subjects. A total of 30 subjects (6 subjects per renal function category [normal, mild, moderate, or severe impairment; and end-stage renal disease (ESRD)]) were enrolled and completed the study...
August 23, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28827482/insulin-neuritis-and-effect-of-pregabalin
#13
Yasser Aladdin, Thomas Jeerakathil, Zaeem A Siddiqi
INTRODUCTION: Insulin neuritis (IN) is a rare condition that results in acute painful neuropathy. It occurs classically in patients with diabetes mellitus with uncontrolled sugar levels who are started on insulin therapy leading to a precipitous normalization of blood sugar levels. The condition is heralded by severe and generalized burning pain along with significant weight loss and mood issues. The diagnosis is mainly clinical and the etiology of IN remains obscure. METHODS AND RESULTS: We report on 2 cases who developed acute and excruciating neuropathic pain after institution of insulin therapy for poorly controlled diabetes mellitus...
September 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/28819738/high-dose-8-capsaicin-patch-in-treatment-of-chemotherapy-induced-peripheral-neuropathy-single-center-experience
#14
Iwona Filipczak-Bryniarska, Roger M Krzyzewski, Jakub Kucharz, Anna Michalowska-Kaczmarczyk, Justyna Kleja, Jarosław Woron, Katarzyna Strzepek, Lucyna Kazior, Jerzy Wordliczek, Tomasz Grodzicki, Krzysztof Krzemieniecki
High-dose capsaicin patch is effective in treatment of neuropathic pain in HIV-associated neuropathy and diabetic neuropathy. There are no studies assessing effectiveness of high-dose capsaicin patch in treatment of chemotherapy-induced peripheral neuropathy. We sought to determine the effectiveness of treatment of pain associated with chemotherapy-induced peripheral neuropathy with high-dose capsaicin patch. Our study group consisted of 18 patients with clinically confirmed oxaliplatin-induced neuropathy. Baseline characteristic including underling disease, received cumulative dose of neurotoxic agent, neuropathic symptoms, prior treatment and initial pain level were recorded...
August 17, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28813083/ankle-brachial-index-and-diabetic-neuropathy-study-of-225-patients
#15
Liliana Chevtchouk, Marcio Heitor Stelmo da Silva, Osvaldo José Moreira do Nascimento
Objective: To evaluate neuropathic pain and peripheral vascular disease in diabetics and compare this with the length of time since diagnosis in type 1, and type 2 diabetes. Methods: A cross-sectional study with 225 diabetics chosen from their responses on the DN4 questionnaire, who were then evaluated with the ankle-brachial index (ABI), separating type 1 diabetes from type 2 diabetes. Results: A higher incidence of neuropathic pain in those over 60 years of age showed an ABI > 1...
August 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28802070/memantine-for-the-treatment-of-general-neuropathic-pain-a-narrative-review
#16
REVIEW
Gisèle Pickering, Véronique Morel
Neuropathic pain (NP) is difficult to treat and is associated with a decline in quality of life. NP aetiologies are numerous and a number of pathologies display neuropathic characteristics. Of the various N-Methyl-D-Aspartate antagonists that are alternatives to recommended in first-line NP treatment, memantine has the safest side-effect profile and has long been approved in Alzheimer's disease. The review covers memantine studies in post-herpetic neuralgia, diabetic pain, postoperative pain, complex regional pain syndrome, chronic phantom limb pain, opioid refractory pain, and fibromyalgia...
August 12, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28799796/immune-modulation-by-curcumin-the-role-of-interleukin-10
#17
Hamid Mollazadeh, Arrigo F G Cicero, Christopher N Blesso, Matteo Pirro, Muhammed Majeed, Amirhossein Sahebkar
Cytokines are small secreted proteins released by different types of cells with specific effects on cellular signaling and communication via binding to their receptors on the cell surface. IL-10 is known to be a pleiotropic and potent anti-inflammatory and immunosuppressive cytokine that is produced by both innate and adaptive immunity cells including dendritic cells, macrophages, mast cells, natural killer cells, eosinophils, neutrophils, B cells, CD8(+) T cells, and TH1, TH2, and TH17 and regulatory T cells...
August 11, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28794656/neuropathic-pain-responds-better-to-increased-doses-of-pregabalin-an-in-depth-analysis-of-flexible-dose-clinical-trials
#18
Michael Serpell, Mark Latymer, Mary Almas, Marie Ortiz, Bruce Parsons, Rita Prieto
BACKGROUND: Pregabalin is an effective treatment option for many patients with neuropathic pain. Higher doses of pregabalin have been shown to be more effective in improving pain outcomes but, in practice, failing to appropriately increase the dose can leave patients under-treated. METHODS: This was a pooled analysis of 6 flexible-dose clinical trials of pregabalin in patients with neuropathic pain (diabetic peripheral neuropathy, peripheral herpetic neuralgia, posttraumatic pain, or postsurgical pain)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28772216/minocycline-attenuates-the-development-of-diabetic-neuropathy-by-inhibiting-spinal-cord-notch-signaling-in-rat
#19
Cheng Yang, Jie Gao, Banglin Wu, Nuo Yan, Hui Li, Yiqing Ren, Yufei Kan, Jiamin Liang, Yang Jiao, Yonghao Yu
We studied the effects of minocycline (an inhibitor of microglial activation) on the expression and activity of Notch-1 receptor, and explored the therapeutic efficacy of minocycline combined with Notch inhibitor DAPT in the treatment of diabetic neuropathic pain (DNP). Diabetic rat model was established by intraperitoneal injection (ip) of Streptozotocin (STZ). Expression and activity of Notch-1 and expression of macrophage/microglia marker Iba-1 were detected by WB. Diabetes induction significantly attenuated sciatic nerve conduction velocity, and dramatically augmented the expression and the activity of Notch-1 in the lumbar enlargement of the spinal cord...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28751195/antinociceptive-antiallodynic-and-antihyperalgesic-effects-of-the-5-ht1a-receptor-selective-agonist-nlx-112-in-mouse-models-of-pain
#20
Kinga Sałat, Marcin Kołaczkowski, Anna Furgała, Adriana Rojek, Joanna Śniecikowska, Mark A Varney, Adrian Newman-Tancredi
BACKGROUND AND PURPOSE: NLX-112 (a.k.a. befiradol, F13640) is a drug candidate intended for the treatment of l-DOPA-induced dyskinesia. It is a highly selective serotonin 5-HT1A receptor full agonist which has been previously tested in a variety of models of CNS effects including analgesic activity in rat. Its activity in mouse models of pain has not been previously investigated. EXPERIMENTAL APPROACH: The activity of NLX-112 was tested in mouse models of acute pain (hot plate), tonic pain (intraplantar formalin test), in the oxaliplatin-induced neuropathic pain model of chemotherapy-induced peripheral neuropathy and in the streptozotocin (STZ)-induced model of painful diabetic neuropathy...
July 24, 2017: Neuropharmacology
keyword
keyword
43022
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"