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Diabetic neuropathic pain

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https://www.readbyqxmd.com/read/28535564/the-different-dynamic-changes-of-nerve-growth-factor-in-the-dorsal-horn-and-dorsal-root-ganglion-leads-to-hyperalgesia-and-allodynia-in-diabetic-neuropathic-pain
#1
Zhifeng Gao, Yi Feng, Hui Ju
BACKGROUND: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes and more than half of the patients with DPN have self-reported symptoms referring to painful diabetic neuropathy (PDN). Nerve growth factor (NGF) is a key factor for the nervous system, but the role of it in the neuropathic pain of diabetic patients is unclear. OBJECTIVE: This study aimed to investigate the relationship between the dynamic expression of NGF in dorsal horn and dorsal root ganglion (DRG) of diabetic rats and hyperalgesia and allodynia in diabetic neuropathic pain...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28532680/decreased-spinal-endomorphin-2-contributes-to-mechanical-allodynia-in-streptozotocin-induced-diabetic-rats
#2
Le Niu, Guang-Hai Dai, Gao-Le He, Ming Yang, Hui-Min Hu, Zhong-Kai Liu, Nian-Song Qian, Yong-Liang Chen
Diabetic neuropathic pain (DNP) plays a major role in decreased life quality of diabetes patients, however, the neural mechanisms underlying DNP remain unclear. Endomorphins are the endogenous ligands for mu-opioid receptor. There is increasing evidence implicating the involvement of spinal endomorphin-2 (EM2) in neuropathic pain. In this study, using a streptozotocin induced diabetic rat model that displayed obvious mechanical allodynia, it was found that the expression of spinal EM2 was significantly decreased in DNP rats...
May 19, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28530786/morphine-for-chronic-neuropathic-pain-in-adults
#3
REVIEW
Tess E Cooper, Junqiao Chen, Philip J Wiffen, Sheena Derry, Daniel B Carr, Dominic Aldington, Peter Cole, R Andrew Moore
BACKGROUND: Neuropathic pain, which is caused by a lesion or disease affecting the somatosensory system, may be central or peripheral in origin. Neuropathic pain often includes symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity to normally painful stimuli. Neuropathic pain is a common symptom in many diseases of the nervous system. Opioid drugs, including morphine, are commonly used to treat neuropathic pain...
May 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28529795/crystal-structure-of-isopropyl-2-hy-droxy-2-phenyl-acetate-a-pharmacopoeia-reference-standard
#4
Ivan Isaiev, Svitlana Shishkina, Igor Ukrainets, Elena Bevz
The title compound, C11H14O3, is used as a pharmacopoeia reference standard for determining impurities in the drug Pregabalin, used for the treatment of epilepsy and diabetic neuropathic pain. The mol-ecule is far from being planar, with the dihedral angle between the planes of the aromatic ring and the carboxyl fragment (O-C=O) being 76.1 (6)°. The isopropyl substituent is located in a synperiplanar position relative to the C=O bond and is turned so that the C-O-C-H torsion angle is -43.7°. In the crystal, bifurcated O-H⋯(O,O) hydrogen bonds, enclosing R1(2)(5) ring motifs, lead to the formation of chains propagating along the c-axis direction...
May 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28514232/ppar%C3%AE-agonists-attenuate-trigeminal-neuropathic-pain
#5
Danielle N Lyons, Liping Zhang, Robert J Danaher, Craig S Miller, Karin N Westlund
The aim of this study is to investigate the role of peroxisome proliferator-activated receptor-gamma isoform (PPARγ), in trigeminal neuropathic pain utilizing a novel mouse trigeminal inflammatory compression (TIC) injury model. The study determined that the PPARγ nuclear receptor plays a significant role in trigeminal nociception transmission, evidenced by: (1) Intense PPARγ immunoreactivity is expressed 3 weeks after TIC nerve injury in the spinal trigeminal caudalis, the termination site of trigeminal nociceptive nerve fibers...
May 16, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28506898/chromane-isolated-from-leaves-of-dillenia-indica-improves-the-neuronal-dysfunction-in-stz-induced-diabetic-neuropathy
#6
Navpreet Kaur, Lalit Kishore, Randhir Singh
ETHNOPHARMACOLOGICAL RELEVANCE: According to the Indian traditional medicine, Dillenia indica L. has shown therapeutic efficacy in various diseases. Fruits and leaves of the plant possess anti-oxidant and anti-inflammatory properties. Reactive oxygen species, formation of advanced glycation end products (AGEs) and apoptosis are implicated in the pathogenesis of diabetic neuropathy. AIM OF THE STUDY: The aim of the present study was to explore the effect of D. indica and its isolate, chromane (CR), on thermal and mechanical hyperalgesia, allodynia, MNCV and oxidative-nitrosative stress in streptozotocin-induced experimental diabetes...
May 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28476630/membrane-lipid-therapy-a-historical-perspective-of-membrane-targeted-therapies-from-lipid-bilayer-structure-to-the-pathophysiological-regulation-of-cells
#7
REVIEW
Pablo V Escribá
Our current understanding of membrane lipid composition, structure and functions has led to the investigation of their role in cell signaling, both in healthy and pathological cells. As a consequence, therapies based on the regulation of membrane lipid composition and structure have been recently developed. This novel field, known as Membrane Lipid Therapy, is growing and evolving rapidly, providing treatments that are now in use or that are being studied for their application to oncological disorders, Alzheimer's disease, spinal cord injury, stroke, diabetes, obesity, and neuropathic pain...
May 2, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28476321/murine-model-and-mechanisms-of-treatment-induced-painful-diabetic-neuropathy
#8
Juliet M Nicodemus, Cynthia Enriquez, Alexandra Marquez, Carlos J Anaya, Corinne G Jolivalt
Diabetes mellitus represents a group of metabolic diseases that are characterized by hyperglycemia caused by either lack of insulin production or a reduced ability to respond to insulin. It is estimated that there were 347 million people worldwide who suffered from diabetes in 2008 and incidence is predicted to double by 2050. Neuropathy is the most common complication of long-term diabetes and approximately 30% of these subjects develop chronic neuropathic pain. A distinct acute, severe form of neuropathic pain, called insulin neuritis or treatment-induced painful neuropathy of diabetes (TIND), may also occur shortly after initiation of intensive glycemic control, with an incidence rate of up to 10...
May 3, 2017: Neuroscience
https://www.readbyqxmd.com/read/28473361/seizure-induced-by-sudden-cessation-of-pregabalin-in-a-patient-with-chronic-kidney-disease
#9
Yang Timothy Du, Anthony P Roberts, David J Torpy
A middle-aged woman with diabetic nephropathy on pregabalin for neuropathic pain presented with a diarrhoeal illness. She was found to have acute on chronic renal impairment with an estimated glomerular filtration rate (eGFR) of 10 mL/min, and her usual 150 mg/day of pregabalin was abruptly ceased. Although renal recovery to her baseline of eGFR 15 mL/min was achieved within 3 days, her pregabalin was not restarted. She suffered a tonic-clonic seizure 4 days later, thought to be due to pregabalin withdrawal as there were no other likely causes identified...
May 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28455594/-polyneuropathy-in-the-elderly
#10
Wolfgang Löscher, Bernhard Iglseder
The peripheral nervous system is subject to changes during the ageing process, e. g. deep tendon reflexes decrease, as does proprioception. Polyneuropathies, on the other hand, need to be distinguished from age-related changes as independent diseases with etiologies similar to those at younger ages. Etiologies includes metabolic disorders, primary inflammatory polyneuropathies, and systemic disorders. Neuropathies associated with diabetes, malignancy, and monoclonal gammopathies appear to be more common in older patients...
April 28, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28435312/prevalence-of-chronic-pain-with-neuropathic-characteristics-a-randomized-telephone-survey-among-medical-center-patients-in-kuwait
#11
Nadia Zghoul, Edgar L Ross, Robert R Edwards, Adel Ahmed, Robert N Jamison
BACKGROUND: Chronic pain with neuropathic characteristics is considered to be an international health problem. However, surveys on the actual incidence of neuropathic pain have not been conducted in many Middle East countries, including Kuwait. The aim of this study was to examine the incidence of pain and medical comorbidities among a random sample of patients treated at a large medical center in Kuwait. METHODS: A list of 1,000 patients was created from the hospital medical record system, and a telephone survey was conducted on 759 patients who responded to the phone call, of which 67...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28431564/effectiveness-of-the-capsaicin-8-patch-in-the-management-of-peripheral-neuropathic-pain-in-european-clinical-practice-the-ascend-study
#12
Colette Mankowski, Chris D Poole, Etienne Ernault, Roger Thomas, Ellen Berni, Craig J Currie, Cecil Treadwell, José I Calvo, Christina Plastira, Eirini Zafeiropoulou, Isaac Odeyemi
BACKGROUND: In randomised studies, the capsaicin 8% patch has demonstrated effective pain relief in patients with peripheral neuropathic pain (PNP) arising from different aetiologies. METHODS: ASCEND was an open-label, non-interventional study of patients with non-diabetes-related PNP who received capsaicin 8% patch treatment, according to usual clinical practice, and were followed for ≤52 weeks. Co-primary endpoints were percentage change in the mean numeric pain rating scale (NPRS) 'average daily pain' score from baseline to the average of Weeks 2 and 8 following first treatment; and median time from first to second treatment...
April 21, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28410768/-small-fiber-neuropathy
#13
V Langlois, A-L Bedat Millet, M Lebesnerais, S Miranda, F Marguet, Y Benhamou, P Marcorelles, H Lévesque
Small fiber neuropathy (SFN) is still unknown. Characterised by neuropathic pain, it typically begins by burning feet, but could take many other expression. SFN affects the thinly myelinated Aδ and unmyelinated C-fibers, by an inherited or acquired mechanism, which could lead to paresthesia, thermoalgic disorder or autonomic dysfunction. Recent studies suggest the preponderant role of ion channels such as Nav1.7. Furthermore, erythromelalgia or burning mouth syndrome are now recognized as real SFN. Various aetiologies of SFN are described...
April 11, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28396715/immunomodulatory-oligonucleotide-imt504-effects-on-mesenchymal-stem-cells-as-a-first-in-class-immunoprotective-immunoregenerative-therapy
#14
REVIEW
Jorge Zorzopulos, Steven M Opal, Andrés Hernando-Insúa, Juan M Rodriguez, Fernanda Elías, Juan Fló, Ricardo A López, Norma A Chasseing, Victoria A Lux-Lantos, Maria F Coronel, Raul Franco, Alejandro D Montaner, David L Horn
The immune responses of humans and animals to insults (i.e., infections, traumas, tumoral transformation and radiation) are based on an intricate network of cells and chemical messengers. Abnormally high inflammation immediately after insult or abnormally prolonged pro-inflammatory stimuli bringing about chronic inflammation can lead to life-threatening or severely debilitating diseases. Mesenchymal stem cell (MSC) transplant has proved to be an effective therapy in preclinical studies which evaluated a vast diversity of inflammatory conditions...
March 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/28389414/niclosamide-beyond-an-antihelminthic-drug
#15
REVIEW
Wei Chen, Robert A Mook, Richard T Premont, Jiangbo Wang
Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of people worldwide. However recent studies have indicated that niclosamide may have broad clinical applications for the treatment of diseases other than those caused by parasites. These diseases and symptoms may include cancer, bacterial and viral infection, metabolic diseases such as Type II diabetes, NASH and NAFLD, artery constriction, endometriosis, neuropathic pain, rheumatoid arthritis, sclerodermatous graft-versus-host disease, and systemic sclerosis...
April 4, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28385653/optimizing-adaptive-design-for-phase-2-dose-finding-trials-incorporating-long-term-success-and-financial-considerations-a-case-study-for-neuropathic-pain
#16
Jingjing Gao, Narinder Nangia, Jia Jia, James Bolognese, Jaydeep Bhattacharyya, Nitin Patel
In this paper, we propose an adaptive randomization design for Phase 2 dose-finding trials to optimize Net Present Value (NPV) for an experimental drug. We replace the traditional fixed sample size design (Patel, et al., 2012) by this new design to see if NPV from the original paper can be improved. Comparison of the proposed design to the previous design is made via simulations using a hypothetical example based on a Diabetic Neuropathic Pain Study.
April 4, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28383710/the-mobile-study-a-phase-iia-enriched-enrollment-randomized-withdrawal-trial-to-assess-the-analgesic-efficacy-and-safety-of-asp8477-a-fatty-acid-amide-hydrolase-inhibitor-in-patients-with-peripheral-neuropathic-pain
#17
Daniel Bradford, Anjali Stirling, Etienne Ernault, Maggie Liosatos, Katherine Tracy, Jennifer Moseley, Paul Blahunka, Mike D Smith
Objective.:  To evaluate the analgesic efficacy and safety of ASP8477 in patients with peripheral neuropathic pain (PNP). Design.:  Enriched enrollment randomized withdrawal. Setting.:  Centers in Poland (four), Czech Republic (six), and the United Kingdom (two). Subjects.:  Patients aged 18 years or older with PNP resulting from painful diabetic peripheral neuropathy or postherpetic neuralgia. Methods...
April 5, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28381989/bioactive-fraction-of-annona-reticulata-bark-or-ziziphus-jujuba-root-bark-along-with-insulin-attenuates-painful-diabetic-neuropathy-through-inhibiting-nf-%C3%AE%C2%BAb-inflammatory-cascade
#18
Raghuram Kandimalla, Suvakanta Dash, Sanjeeb Kalita, Bhaswati Choudhury, Sandeep Malampati, Rajlakshmi Devi, Muthiah Ramanathan, Narayan C Talukdar, Jibon Kotoky
The present study explains the neuroprotective ability of bioactive fractions of Annona reticulata bark (ARB) and Ziziphus jujuba root bark (ZJ) along with insulin against diabetic neuropathy. By using different solvents of increasing polarity ARB and ZJ were undergone for bioactive guided fractionation. The neuroprotective ability of the all the plant fractions were tested against H2O2 induced toxicity in SHSY5Y neuroblastoma cell lines and DRG neuronal cells. Among all the fractions tested, the methanol extract of ARB and ZJ (ARBME and ZJME) and its water fractions (ARBWF and ZJWF) exhibited significant neuroprotection against H2O2 induced toxicity in SHSY5Y cells and DRG neuronal cells...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28375916/neuropathic-pain
#19
Lindsay A Zilliox
PURPOSE OF REVIEW: Neuropathic pain is a frequently encountered condition that is often resistant to treatment and is associated with poor patient satisfaction of their treatment. Several medications have been shown to be effective in treating neuropathic pain associated with diabetic neuropathy and postherpetic neuralgia, and these medications are often used to treat neuropathic pain associated with other conditions as well. This article summarizes the diagnosis and assessment of patients with neuropathic pain as well as available pharmacologic and interventional treatment options...
April 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28372633/effects-of-danggui-sini-decoction-on-neuropathic-pain-experimental-studies-and-clinical-pharmacological-significance-of-inhibiting-glial-activation-and-proinflammatory-cytokines-in-the-spinal-cord%C3%A2
#20
Ming Liu, Qiu Hong Qiang, Qian Ling, Chang Xi Yu, Xuejun Li, Suhuan Liu, Shuyu Yang
AIM: Neuropathic pain responds poorly to drug treatments. Partial relief is achieved in only about half of the patients. Danggui Sini decoction (DSD), an aqueous extract of <i>Angelica sinensis, Ramulus Cinnamomi,</i> and <i>Radix Puerariae</i>, has been used extensively in China to treat inflammatory and ischemic diseases. The current study examined the putative effects of DSD on neuropathic pain. METHOD: We used two commonly-used animal models: chronic constriction injury (CCI) and diabetic neuropathy for the study...
May 2017: International Journal of Clinical Pharmacology and Therapeutics
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