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Diabetic neuropathic pain

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https://www.readbyqxmd.com/read/28616956/tramadol-for-neuropathic-pain-in-adults
#1
REVIEW
Rudolf Martin Duehmke, Sheena Derry, Philip J Wiffen, Rae F Bell, Dominic Aldington, R Andrew Moore
BACKGROUND: This review is an update of a review of tramadol for neuropathic pain, published in 2006; updating was to bring the review in line with current standards. Neuropathic pain, which is caused by a lesion or disease affecting the somatosensory system, may be central or peripheral in origin. Peripheral neuropathic pain often includes symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity to normally painful stimuli...
June 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28616712/vesicular-nucleotide-transporter-vnut-appearance-of-an-actress-on-the-stage-of-purinergic-signaling
#2
REVIEW
Yoshinori Moriyama, Miki Hiasa, Shohei Sakamoto, Hiroshi Omote, Masatoshi Nomura
Vesicular storage of ATP is one of the processes initiating purinergic chemical transmission. Although an active transport mechanism was postulated to be involved in the processes, a transporter(s) responsible for the vesicular storage of ATP remained unidentified for some time. In 2008, SLC17A9, the last identified member of the solute carrier 17 type I inorganic phosphate transporter family, was found to encode the vesicular nucleotide transporter (VNUT) that is responsible for the vesicular storage of ATP...
June 14, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28605119/aromatherapy-massage-for-neuropathic-pain-and-quality-of-life-in-diabetic-patients
#3
Zehra Gok Metin, Ayse Arikan Donmez, Nur Izgu, Leyla Ozdemir, Ismail Emre Arslan
PURPOSE: This study aimed to examine the effects of aromatherapy massage on neuropathic pain severity and quality of life (QoL) in patients suffering from painful diabetic neuropathy. DESIGN AND METHODS: This open-label randomized controlled clinical study was conducted in a university hospital endocrine outpatient clinic in Turkey. The study sample consisted of 46 patients, randomly allocated to an intervention group (n = 21) and a control group (n = 25). The intervention group received aromatherapy massage three times per week for a period of 4 weeks...
June 12, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28599823/neuropathy-and-presence-of-emotional-distress-and-depression-in-longstanding-diabetes-results-from-the-canadian-study-of-longevity-in-type-1-diabetes
#4
Johnny-Wei Bai, Leif E Lovblom, Marina Cardinez, Alanna Weisman, Mohammed A Farooqi, Elise M Halpern, Genevieve Boulet, Devrim Eldelekli, Julie A Lovshin, Yuliya Lytvyn, Hillary A Keenan, Michael H Brent, Narinder Paul, Vera Bril, David Z I Cherney, Bruce A Perkins
AIM: To determine the association of neuropathy and other complications with emotional distress and depression among patients with longstanding type 1 diabetes (T1DM). METHODS: Canadians with ≥50years of T1DM completed a questionnaire including assessment of distress and depression by the Problem Areas in Diabetes Scale (PAID) and Geriatric Depression Scale (GDS), respectively. Complications were determined using the Michigan Neuropathy Screening Instrument (Questionnaire Component), fundoscopy reports, renal function tests, and self-reported peripheral-(PVD) and cardiovascular (CVD) disease...
May 10, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28598552/acrolein-scavenger-hydralazine-prevents-streptozotocin-induced-painful-diabetic-neuropathy-and-spinal-neuroinflammation-in-rats
#5
Lu Yao, Yun-Tao Wu, Guo-Xiang Tian, Chang-Quan Xia, Feng Zhang, Wei Zhang
Diabetes-induced neuropathic pain (DNP) substantially influences people's life qualities. Hyperglycemia-induced excess free radicals have been considered as the most critical mechanisms underlying DNP. As an unsaturated aldehyde and a reactive product of lipid peroxidation, acrolein plays critical roles in diabetic nephropathy and inflammatory pain. We sought to determine whether acrolein is involved in DNP in the present study. Diabetes was induced by a single intraperitoneal (i.p.) injection of 60 mg/kg streptozotocin (STZ)...
June 9, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28597471/gabapentin-for-chronic-neuropathic-pain-in-adults
#6
REVIEW
Philip J Wiffen, Sheena Derry, Rae F Bell, Andrew Sc Rice, Thomas Rudolf Tölle, Tudor Phillips, R Andrew Moore
BACKGROUND: Gabapentin is commonly used to treat neuropathic pain (pain due to nerve damage). This review updates a review published in 2014, and previous reviews published in 2011, 2005 and 2000. OBJECTIVES: To assess the analgesic efficacy and adverse effects of gabapentin in chronic neuropathic pain in adults. SEARCH METHODS: For this update we searched CENTRAL), MEDLINE, and Embase for randomised controlled trials from January 2014 to January 2017...
June 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28596150/pain-improvement-with-novel-combination-analgesic-regimens-pain-care-randomized-controlled-trial-protocol
#7
Ian Gilron, Dongsheng Tu, Ronald Holden, Alan C Jackson, Nader Ghasemlou, Scott Duggan, Elizabeth Vandenkerkhof, Roumen Milev
BACKGROUND: Neuropathic pain (NP) (including painful diabetic neuropathy, postherpetic neuralgia, etc) affects approximately 7% to 8% of the population and is associated with a devastating symptom burden as well as a profound economic impact for patients, their families, and the health care system. Current therapies have limited efficacy and dose-limiting adverse effects (AEs). Rational combination therapy with carefully selected NP drugs has shown potential for measurable improvements in pain relief, quality of life, and health care use...
June 8, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28595241/stratifying-patients-with-peripheral-neuropathic-pain-based-on-sensory-profiles-algorithm-and-sample-size-recommendations
#8
Jan Vollert, Christoph Maier, Nadine Attal, David L H Bennett, Didier Bouhassira, Elena K Enax-Krumova, Nanna B Finnerup, Rainer Freynhagen, Janne Gierthmühlen, Maija Haanpää, Per Hansson, Philipp Hüllemann, Troels S Jensen, Walter Magerl, Juan D Ramirez, Andrew S C Rice, Sigrid Schuh-Hofer, Märta Segerdahl, Jordi Serra, Pallai R Shillo, Soeren Sindrup, Solomon Tesfaye, Andreas C Themistocleous, Thomas R Tölle, Rolf-Detlef Treede, Ralf Baron
In a recent cluster analysis, it has been shown that patients with peripheral neuropathic pain can be grouped into 3 sensory phenotypes based on quantitative sensory testing profiles, which are mainly characterized by either sensory loss, intact sensory function and mild thermal hyperalgesia and/or allodynia, or loss of thermal detection and mild mechanical hyperalgesia and/or allodynia. Here, we present an algorithm for allocation of individual patients to these subgroups. The algorithm is nondeterministic-ie, a patient can be sorted to more than one phenotype-and can separate patients with neuropathic pain from healthy subjects (sensitivity: 78%, specificity: 94%)...
June 7, 2017: Pain
https://www.readbyqxmd.com/read/28587350/effects-of-hyperbaric-factors-on-lidocaine-induced-apoptosis-in-spinal-neurons-and-the-role-of-p38-mitogen-activated-protein-kinase-in-rats-with-diabetic-neuropathic-pain
#9
Xiaolan Zheng, Ling Chen, Xiaohong Du, Junying Cai, Shuchun Yu, Hongtao Wang, Guohai Xu, Zhenzhong Luo
The application of lidocaine can lead to nerve damage. Evidence suggests that patients with diabetic neuropathy are at a higher risk for neurotoxicity. In the present study, the successful induction of diabetic neuropathic pain (DNP) in rats via a high-sugar, high-fat diet and intraperitoneal injection of 1% streptozotocin was verified and pronounced tactile allodynia was observed. It was found that intrathecal injections of hyperbaric lidocaine produced motor blocks of longer durations in the DNP model rats than in nondiabetic rats, or in DNP model rats injected with isobaric lidocaine...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28577973/membrane-lipid-therapy-a-historical-perspective-of-membrane-targeted-therapies-from-lipid-bilayer-structure-to-the-pathophysiological-regulation-of-cells
#10
EDITORIAL
Pablo V Escribá
Our current understanding of membrane lipid composition, structure and functions has led to the investigation of their role in cell signaling, both in healthy and pathological cells. As a consequence, therapies based on the regulation of membrane lipid composition and structure have been recently developed. This novel field, known as Membrane Lipid Therapy, is growing and evolving rapidly, providing treatments that are now in use or that are being studied for their application to oncological disorders, Alzheimer's disease, spinal cord injury, stroke, diabetes, obesity, and neuropathic pain...
June 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28575508/effects-of-duloxetine-on-the-toll-like-receptor-4-signaling-pathway-in-spinal-dorsal-horn-in-a-rat-model-of-diabetic-neuropathic-pain
#11
Dong-Mei Zhou, Ying Zhuang, Wen-Jun Chen, Wei Li, Bei Miao
Objective. : Although duloxetine has been approved for clinical therapy for diabetic peripheral neuropathic pain, the exact mechanism underlying the anti-allodynic effects in rat models of diabetes mellitus remains obscure. We attempted to identify whether duloxetine exerts anti-allodynic effects via inhibition of the TLR4-Myd88-dependent pathway in diabetic neuropathic pain (DNP) rats. Methods. : An animal model of type 1 diabetic neuropathic pain was induced by intraperitoneal streptozotocin in 108 rats randomized into four groups: control, DNP, solvent control + DNP, and DNP + duloxetine...
May 29, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28571697/effects-of-monochromatic-infrared-phototherapy-in-patients-with-diabetic-peripheral-neuropathy-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#12
REVIEW
Caroline Cabral Robinson, Patrícia Da Silva Klahr, Cinara Stein, Maicon Falavigna, Graciele Sbruzzi, Rodrigo Della Méa Plentz
BACKGROUND: Monochromatic infrared energy (MIRE) or phototherapy has been used to improve plantar sensitivity and pain in lower limbs of patients with diabetic sensorimotor peripheral neuropathy (DSPN), but the available primary results are inconsistent. OBJECTIVE: To review systematically the effects of MIRE on plantar sensitivity and neuropathic pain in patients with DSPN. METHODS: Medline, EMBASE, Cochrane CENTRAL, and Google Scholar were searched up to September 2016...
May 20, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28557178/impact-of-etiology-and-duration-of-pain-on-pharmacological-treatment-effects-in-painful-polyneuropathy
#13
S H Sindrup, J Holbech, D Demant, N B Finnerup, F W Bach, T S Jensen
BACKGROUND: The pharmacological treatments for painful polyneuropathy have not changed much for more than a decade, and less than half of the patients obtain adequate pain relief with first line treatments. Therefore, patient-specific factors which could predict drug response are searched for. METHODS: We analysed data from four published, randomized, controlled trials of drugs in painful polyneuropathy to see if diabetic etiology and duration of neuropathic pain had an impact on drug efficacy...
May 30, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28554530/electrical-muscle-stimulation-induces-an-increase-of-vegfr2-on-circulating-hematopoietic-stem-cells-in-patients-with-diabetes
#14
Asa Hidmark, Ioannis Spanidis, Thomas H Fleming, Nadine Volk, Volker Eckstein, Jan B Groener, Stefan Kopf, Peter P Nawroth, Dimitrios Oikonomou
PURPOSE: External electric muscle stimulation (EMS) of the thigh muscles was found to reduce pain resulting from diabetic neuropathy (DN), a vascular complication of diabetes. This study investigated circulating hematopoietic stem cells (HSCs) after EMS treatment. Impaired function of HSCs and the subpopulation endothelial progenitor cells (EPCs), important for neovascularization and endothelial repair, has been associated with DN. METHODS: Twenty-four patients with painful DN were treated 3 times with EMS over a period of 1 week...
May 26, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28535564/the-different-dynamic-changes-of-nerve-growth-factor-in-the-dorsal-horn-and-dorsal-root-ganglion-leads-to-hyperalgesia-and-allodynia-in-diabetic-neuropathic-pain
#15
Zhifeng Gao, Yi Feng, Hui Ju
BACKGROUND: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes and more than half of the patients with DPN have self-reported symptoms referring to painful diabetic neuropathy (PDN). Nerve growth factor (NGF) is a key factor for the nervous system, but the role of it in the neuropathic pain of diabetic patients is unclear. OBJECTIVE: This study aimed to investigate the relationship between the dynamic expression of NGF in dorsal horn and dorsal root ganglion (DRG) of diabetic rats and hyperalgesia and allodynia in diabetic neuropathic pain...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28532680/decreased-spinal-endomorphin-2-contributes-to-mechanical-allodynia-in-streptozotocin-induced-diabetic-rats
#16
Le Niu, Guang-Hai Dai, Gao-Le He, Ming Yang, Hui-Min Hu, Zhong-Kai Liu, Nian-Song Qian, Yong-Liang Chen
Diabetic neuropathic pain (DNP) plays a major role in decreased life quality of diabetes patients, however, the neural mechanisms underlying DNP remain unclear. Endomorphins are the endogenous ligands for mu-opioid receptor. There is increasing evidence implicating the involvement of spinal endomorphin-2 (EM2) in neuropathic pain. In this study, using a streptozotocin induced diabetic rat model that displayed obvious mechanical allodynia, it was found that the expression of spinal EM2 was significantly decreased in DNP rats...
May 19, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28530786/morphine-for-chronic-neuropathic-pain-in-adults
#17
REVIEW
Tess E Cooper, Junqiao Chen, Philip J Wiffen, Sheena Derry, Daniel B Carr, Dominic Aldington, Peter Cole, R Andrew Moore
BACKGROUND: Neuropathic pain, which is caused by a lesion or disease affecting the somatosensory system, may be central or peripheral in origin. Neuropathic pain often includes symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity to normally painful stimuli. Neuropathic pain is a common symptom in many diseases of the nervous system. Opioid drugs, including morphine, are commonly used to treat neuropathic pain...
May 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28529795/crystal-structure-of-isopropyl-2-hy-droxy-2-phenyl-acetate-a-pharmacopoeia-reference-standard
#18
Ivan Isaiev, Svitlana Shishkina, Igor Ukrainets, Elena Bevz
The title compound, C11H14O3, is used as a pharmacopoeia reference standard for determining impurities in the drug Pregabalin, used for the treatment of epilepsy and diabetic neuropathic pain. The mol-ecule is far from being planar, with the dihedral angle between the planes of the aromatic ring and the carboxyl fragment (O-C=O) being 76.1 (6)°. The isopropyl substituent is located in a synperiplanar position relative to the C=O bond and is turned so that the C-O-C-H torsion angle is -43.7°. In the crystal, bifurcated O-H⋯(O,O) hydrogen bonds, enclosing R1(2)(5) ring motifs, lead to the formation of chains propagating along the c-axis direction...
May 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28514232/ppar%C3%AE-agonists-attenuate-trigeminal-neuropathic-pain
#19
Danielle N Lyons, Liping Zhang, Robert J Danaher, Craig S Miller, Karin N Westlund
The aim of this study is to investigate the role of peroxisome proliferator-activated receptor-gamma isoform (PPARγ), in trigeminal neuropathic pain utilizing a novel mouse trigeminal inflammatory compression (TIC) injury model. The study determined that the PPARγ nuclear receptor plays a significant role in trigeminal nociception transmission, evidenced by: (1) Intense PPARγ immunoreactivity is expressed 3 weeks after TIC nerve injury in the spinal trigeminal caudalis, the termination site of trigeminal nociceptive nerve fibers...
May 16, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28506898/chromane-isolated-from-leaves-of-dillenia-indica-improves-the-neuronal-dysfunction-in-stz-induced-diabetic-neuropathy
#20
Navpreet Kaur, Lalit Kishore, Randhir Singh
ETHNOPHARMACOLOGICAL RELEVANCE: According to the Indian traditional medicine, Dillenia indica L. has shown therapeutic efficacy in various diseases. Fruits and leaves of the plant possess anti-oxidant and anti-inflammatory properties. Reactive oxygen species, formation of advanced glycation end products (AGEs) and apoptosis are implicated in the pathogenesis of diabetic neuropathy. AIM OF THE STUDY: The aim of the present study was to explore the effect of D. indica and its isolate, chromane (CR), on thermal and mechanical hyperalgesia, allodynia, MNCV and oxidative-nitrosative stress in streptozotocin-induced experimental diabetes...
May 13, 2017: Journal of Ethnopharmacology
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