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Diabetic neuropathic pain

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https://www.readbyqxmd.com/read/29139278/improving-pain-control-in-diabetic-neuropathy
#1
Peter Paisley, Mick Serpell
Diabetic neuropathy is thought to affect 1.9% of the world’s population and 50% of patients with a diagnosis of diabetes mellitus which would equate to 2.25 million people in the UK. The term diabetic neuropathy includes multiple distinct clinical entities that have been classified under the broad headings of focal and multifocal neuropathies and symmetrical neuropathies. Peripheral diabetic neuropathy, a chronic distal symmetrical predominantly sensory neuropathy, is the most common form of diabetic neuropathy...
March 2017: Practitioner
https://www.readbyqxmd.com/read/29122628/a-novel-curcumin-derivative-for-the-treatment-of-diabetic-neuropathy
#2
Daniel J Daugherty, Alexandra Marquez, Nigel A Calcutt, David Schubert
Neuropathy is a common complication of long-term diabetes. Proposed mechanisms of neuronal damage caused by diabetes that are downstream of hyperglycemia and/or loss of insulin signaling include ischemic hypoxia, inflammation and loss of neurotrophic support. The curcumin derivative J147 is a potent neurogenic and neuroprotective drug candidate initially developed for the treatment of neurodegenerative conditions associated with aging that impacts many pathways implicated in the pathogenesis of diabetic neuropathy...
November 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29114911/relationship-and-variation-of-diabetes-related-symptoms-sleep-disturbance-and-sleep-related-impairment-in-adults-with-type-2-diabetes
#3
Bingqian Zhu, Laurie Quinn, Cynthia Fritschi
AIM: The objective of this study was to examine whether diabetes-related symptoms (e.g. fatigue, neuropathic pain, diabetes distress and depressive symptoms) were related to sleep disturbance and sleep-related impairment in adults with type 2 diabetes while controlling for potential covariates. BACKGROUND: In people with type 2 diabetes, sleep disturbance and sleep-related impairment are common and likely associated with diabetes-related symptoms. However, limited research has investigated the predictive ability of diabetes-related symptoms on sleep...
November 8, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29112785/associated-conditions-in-small-fiber-neuropathy-a-large-cohort-study-and-review-of-the-literature
#4
Bianca T A de Greef, Janneke G J Hoeijmakers, Carla M L Gorissen-Brouwers, Margot Geerts, Catharina G Faber, Ingemar S J Merkies
BACKGROUND: Small fiber neuropathy (SFN) is a common disorder, leading to neuropathic pain and autonomic symptoms. The objective of this study was to investigate associated conditions in a large cohort of SFN patients and compare the prevalence to healthy individuals. METHODS: A total of 921 patients with pure SFN were screened according to a standardized comprehensive diagnostic algorithm and compared with literature findings. RESULTS: In 53% of the patients, no associated condition could be found...
November 7, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29097792/interactions-of-notch1-and-tlr4-signaling-pathways-in-drg-neurons-of-in-vivo-and-in-vitro-models-of-diabetic-neuropathy
#5
Tianhua Chen, Hao Li, Yiting Yin, Yuanpin Zhang, Zhen Liu, Huaxiang Liu
Understanding the interactions between Notch1 and toll-like receptor 4 (TLR4) signaling pathways in the development of diabetic peripheral neuropathy may lead to interpretation of the mechanisms and novel approaches for preventing diabetic neuropathic pain. In the present study, the interactions between Notch1 and TLR4 signaling pathways were investigated by using dorsal root ganglion (DRG) from diabetic neuropathic pain rats and cultured DRG neurons under high glucose challenge. The results showed that high glucose induced not only Notch1 mRNA, HES1 mRNA, and TLR4 mRNA expression, but also Notch1 intracellular domain (NICD1) and TLR4 protein expression in DRG neurons...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29076666/comparison-of-topical-capsaicin-and-topical-turpentine-oil-for-treatment-of-painful-diabetic-neuropathy
#6
Muhammad Usman Musharraf, Zaheer Ahmad, Zernab Yaqub
BACKGROUND: Diabetes Mellitus is a pandemic of the modern era owing to our rapidly deteriorating lifestyle. Painful diabetic neuropathy is one of the costliest and disabling complications of diabetes mellitus. No single treatment exists to prevent or reverse neuropathic changes or to provide total pain relief. Topical Capsaicin and Turpentine Oil are found to be effective in treatment of painful diabetic neuropathy. METHODS: Patients of either gender with ages between 18 and 70 years having painful diabetic neuropathy already taking one oral drug for painful neuropathy and treatment for diabetes mellitus and an HbA1C less than 8...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29071457/evaluation-of-cebranopadol-a-dually-acting-nociceptin-orphanin-fq-and-opioid-receptor-agonist-in-mouse-models-of-acute-tonic-and-chemotherapy-induced-neuropathic-pain
#7
Kinga Sałat, Anna Furgała, Robert Sałat
BACKGROUND: Cebranopadol (a.k.a. GRT-6005) is a dually acting nociceptin/orphanin FQ and opioid receptor agonist that has been recently developed in Phase 2 clinical trials for painful diabetic neuropathy or cancer pain. It also showed analgesic properties in various rat models of pain and had a better safety profile as compared to equi-analgesic doses of morphine. Since antinociceptive properties of cebranopadol have been studied mainly in rat models, in the present study, we assessed analgesic activity of subcutaneous cebranopadol (10 mg/kg) in various mouse pain models...
October 25, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29052170/the-histopathological-evaluation-of-small-fiber-neuropathy-in-patients-with-vitamin-b12-deficiency
#8
Hafize Nalan Güneş, Can Ebru Bekircan-Kurt, Ersin Tan, Sevim Erdem-Özdamar
Small fiber neuropathy (SFN), due to loss of A-delta and unmyelinated C fibers, is a cause of neuropathic pain. Although the patients with vitamin B12 deficiency are included in SFN studies in the literature, there is no histopathological study investigating the small fiber loss solely in patients with vitamin B12 deficiency. In this pilot study, we aim to demonstrate the intraepidermal nerve fiber density (IENFD) in skin punch biopsy of patients with vitamin B12 deficiency. Ten patients with vitamin B12 deficiency suffering from neuropathic pain and as control group ten patients with vitamin B12 deficiency without neuropathic pain were included...
October 19, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29042815/the-role-of-mir-190a-5p-contributes-to-diabetic-neuropathic-pain-via-targeting-slc17a6
#9
Di Yang, Qinyan Yang, Xinchuan Wei, Yang Liu, Ding Ma, Jiaceng Li, Yongling Wan, Yao Luo
INTRODUCTION: MicroRNAs play a key role in neuropathic pain. In a previous study, miR-190a-5p was significantly downregulated in diabetic neuropathic pain (DNP). However, the role and pathological mechanism of miR-190a-5p in DNP still remain unclear. MATERIALS AND METHODS: DNP model was established. The paw withdrawal thresholds were measured to assess the mechanical nociceptive response. Dual-luciferase reporter assay was used to confirm the target gene of microRNA...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29042249/prevalence-and-biochemical-risk-factors-of-diabetic-peripheral-neuropathy-with-or-without-neuropathic-pain-in-taiwanese-adults-with-type-2-diabetes-mellitus
#10
Yen-Wei Pai, Ching-Heng Lin, I-Te Lee, Ming-Hong Chang
AIMS: To investigate the prevalence and risk factors for diabetic peripheral neuropathy with or without neuropathic pain in Taiwanese. METHODS: A cross-sectional, hospital-based observational study was conducted. We enrolled 2837 adults with type 2 diabetes mellitus. Diabetic peripheral neuropathy with or without pain were diagnosed using 2 validated screening tools, namely the Michigan Neuropathy Screening Instrument and Douleur Neuropathique 4 questionnaire. RESULTS: In our sample, 2233 participants had no neuropathy, 476 had diabetic peripheral neuropathy without pain, and 128 had diabetic peripheral neuropathy with neuropathic pain, representing an overall diabetic peripheral neuropathy prevalence of 21...
September 28, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29039325/comparative-role-of-pregabalin-and-carbamazepine-regarding-efficacy-in-painful-diabetic-neuropathy
#11
Raana Mahmood, Itrat Jawed, M Irfan Khan, Iffat Mahmood, Talat Tariq, Arfa Kamil, Faiza Z Sayeed, Bushra Z Sayeed
Neuropathic pain is the most severe and resistant type of pain which has impact on quality of life and behaviour; it most commonly occurs at night causing disturbed sleep. Diabetes mellitus is a common cause of painful neuropathy. In this study, we are comparing the effectiveness of old treatment Carbamazepine with Pregabalin in painful diabetic neuropathy. The study was an open-label trial conducted in Diabetic Clinic of Medical Unit-III, Jinnah Post-graduate Medical Center, Karachi. The duration of the study was 90 days, from December 2010 to March 2011...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29039152/evaluation-of-the-neuropathic-pain-in-the-smokers
#12
Sercan Bulut Çelik, Hüseyin Can, Melih Kaan Sözmen, Tijen Şengezer, Yusuf Cem Kaplan, Gökçenur Utlu, Alp Şener, Arzu Aybek Yılmaz, Olgu Aygün
OBJECTIVES: Nicotine addiction is one of the most important causes of the general failure of treatment and keeping the habit of smoking. Peripheral neuropathy is a leading factor of smoking. This study aimed to analyze the association of neuropathic pain and addiction levels of individuals. METHODS: The study was performed on the day on which the smokers visited the hospital for any reason. The Douleur Neuropathique 4 (DN-4) Scale and Fagerström Addiction Survey were administered to the individuals after obtaining their consent...
July 2017: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/29026761/postherpetic-neuralgia-diabetic-neuropathy-and-trigeminal-neuralgia-chronic-peripheral-neuropathic-pain-in-58-480-rural-italian-primary-care-patients
#13
Nicola Buono, Hans Thulesius, Ferdinando Petrazzuoli, Elena Castelli, Marco Cambielli
INTRODUCTION: Chronic peripheral neuropathic pain (CPNP) is a condition due to peripheral nervous system diseases or injury, but its prevalence is unknown in Italian primary care. AIM: The aim of this study is to assess the prevalence of CPNP in a rural primary care area in Northern Italy. MATERIALS AND METHODS: A multicenter audit study was carried out in a rural area in Northern Italy with 113 participating general practitioners (GPs) seeing 58,480 patients >18 years during 3 months...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29017758/in-vitro-and-in-vivo-pharmacological-characterization-of-asp8477-a-novel-highly-selective-fatty-acid-amide-hydrolase-inhibitor
#14
Tomonari Watabiki, Noriko Tsuji, Tetsuo Kiso, Tohru Ozawa, Fumie Narazaki, Shuichiro Kakimoto
Although exogenous agonists for cannabinoid (CB) receptors are clinically effective for treating chronic pain, global activation of brain CB receptors causes frequent central nervous system (CNS) side-effects. Fatty acid amide hydrolase (FAAH) is a primary catabolic enzyme for anandamide (AEA), an endogenous CB. Recently, we discovered a novel FAAH inhibitor, 3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate (ASP8477). In vitro studies demonstrated that ASP8477 inhibited human FAAH-1, FAAH-1 (P129T) and FAAH-2 activity with IC50 values of 3...
November 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28979316/how-nitric-oxide-increases-in-diabetic-morphine-tolerated-male-rats
#15
Yassar Mortada, Khojasteh Khojasteh, Malek Zarei, Ardalan Mansouri, Masoumeh Jorjani
Neuropathic pain is a complication of inflammation, infection or some diseases such as diabetes. Opioids are used as a salvage therapy for neuropathic pain but tolerance restricts their use. In our previous study, we have observed an increase of Nitric Oxide in diabetes and in morphine tolerance. This study was performed to clarify the role of inducible nitric oxide synthase, iNOS, and cationic amino acid transporter-2, CAT-2, in these conditions. Thus male rats were divided into four groups: control, diabetic, morphine tolerated, and diabetic morphine tolerated...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28971737/translation-and-cultural-adaptation-of-the-leeds-assessment-of-neuropathic-symptoms-and-signs-lanss-pain-scale-into-arabic-for-use-with-patients-with-diabetes-in-libya
#16
Sabri Garoushi, Mark I Johnson, Osama A Tashani
In Libya neuropathic pain is rarely assessed in patients with diabetes. The Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) pain scale is used worldwide to screen for neuropathic pain. There is no Arabic version of LANSS for use in Libya. The aim of this study was to develop an Arabic version of LANSS and to assess its validity and reliability in diabetic patients in Benghazi, Libya. LANSS was translated into Arabic by four bilingual translators and back translated to English by a university academic...
December 2017: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/28959382/nerve-decompression-and-neuropathy-complications-in-diabetes-are-attitudes-discordant-with-evidence
#17
REVIEW
D Scott Nickerson
External neurolysis of the nerve at fibro-osseous tunnels has been proprosed to treat or prevent signs, symptoms, and complications in the lower extremity of diabetes patients with sensorimotor polyneuropathy. Nerve decompression is justified in the presence of symptomatic compressed nerves in the several fibro-osseous tunnels of the extremities, which are known to be frequent in diabetes. Quite a body of literature has accumulated reporting results after such nerve decompression in the leg, describing pain relief and sensibility improvement, as well as balance recovery, diabetic foot ulcer prevention, curtailed ulcer recurrence risk, and amputation avoidance...
2017: Diabetic Foot & Ankle
https://www.readbyqxmd.com/read/28949996/the-impact-of-team-based-interprofessional-comprehensive-assessments-on-the-diagnosis-and-management-of-diabetic-foot-ulcers-a-retrospective-cohort-study
#18
Ranjani Somayaji, James A Elliott, Reneeka Persaud, Morgan Lim, Laurie Goodman, R Gary Sibbald
BACKGROUND: Diabetic foot ulcers (DFU) are increasingly prevalent, and associated with significant morbidity, mortality, and cost. An interprofessional approach to DFU management is critical given the etiological complexity involved. This study aimed to assess the impact of an interprofessional team approach on DFU diagnosis and management for a cohort of patients receiving treatment in an Ontario Canada home care setting. METHODS: A retrospective cohort study of patients attending a large regional Community Care Access Centre (CCAC) between February 11, 2013-September 30, 2014 was conducted...
2017: PloS One
https://www.readbyqxmd.com/read/28942488/psychological-and-biomechanical-aspects-of-patient-adaptation-to-diabetic-neuropathy-and-foot-ulceration
#19
REVIEW
Loretta Vileikyte, Ryan T Crews, Neil D Reeves
PURPOSE OF REVIEW: The purpose of this review was to elucidate how psychological and biomechanical factors interrelate in shaping patients' experience with diabetic symmetric polyneuropathy (DSPN) and its sequela-diabetic foot ulceration (DFU). RECENT FINDINGS: Recent findings emphasize the importance not only of neuropathic pain but also of other DSPN symptoms, such as unsteadiness. We highlight the negative spiral between unsteadiness, falls, and psychological distress...
September 23, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28928602/lncrna-nonratt021972-was-associated-with-neuropathic-pain-scoring-in-patients-with-type-2-diabetes
#20
Wei Yu, Guo-Qing Zhao, Rang-Juan Cao, Zhi-Hua Zhu, Kai Li
BACKGROUND: Long noncoding RNAs were involved in the processes of diabetes. Our study was aimed to explore clinical potential of LncRNA NONRATT021972 in diabetic neuropathic pain and investigate detailed mechanisms. METHODS: 154 patients with type 2 diabetes were enrolled as experimental group paired with control. Patients without diabetes but neuropathy were enrolled to explore exclusive role of LncRNA NONRATT021972 in neuropathy. Real-time PCR and ELISA were performed to examine expression of LncRNA and TNF-α in flood...
2017: Behavioural Neurology
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