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Emily Pettersen, Paolo Sassu, Carina Reinholdt, Peter Dahm, Ola Rolfson, Anders Björkman, Marco Innocenti, Francesca Alice Pedrini, Juan Manuel Breyer, Aidan Roche, Andrew Hart, Lorraine Harrington, Adil Ladak, Hollie Power, Jacqueline Hebert, Max Ortiz-Catalan
No abstract text is available yet for this article.
October 9, 2023: Trials
#22
JOURNAL ARTICLE
Michael D Kinnaman, Simone Zaccaria, Alvin Makohon-Moore, Brian Arnold, Max F Levine, Gunes Gundem, Juan E Arango Ossa, Dominik Glodzik, M Irene Rodríguez-Sánchez, Nancy Bouvier, Shanita Li, Emily Stockfisch, Marisa Dunigan, Cassidy Cobbs, Umesh K Bhanot, Daoqi You, Katelyn Mullen, Jerry P Melchor, Michael V Ortiz, Tara J O'Donohue, Emily K Slotkin, Leonard H Wexler, Filemon S Dela Cruz, Meera R Hameed, Julia L Glade Bender, William D Tap, Paul A Meyers, Elli Papaemmanuil, Andrew L Kung, Christine A Iacobuzio-Donahue
UNLABELLED: Multiple large-scale genomic profiling efforts have been undertaken in osteosarcoma to define the genomic drivers of tumorigenesis, therapeutic response, and disease recurrence. The spatial and temporal intratumor heterogeneity could also play a role in promoting tumor growth and treatment resistance. We conducted longitudinal whole-genome sequencing of 37 tumor samples from 8 patients with relapsed or refractory osteosarcoma. Each patient had at least one sample from a primary site and a metastatic or relapse site...
November 15, 2023: Cancer Research
#23
JOURNAL ARTICLE
Bahareh Ahkami, Kirstin Ahmed, Alexander Thesleff, Levi Hargrove, Max Ortiz-Catalan
Most amputations occur in lower limbs and despite improvements in prosthetic technology, no commercially available prosthetic leg uses electromyography (EMG) information as an input for control. Efforts to integrate EMG signals as part of the control strategy have increased in the last decade. In this systematic review, we summarize the research in the field of lower limb prosthetic control using EMG. Four different online databases were searched until June 2022: Web of Science, Scopus, PubMed, and Science Direct...
August 2023: IEEE transactions on medical robotics and bionics
#24
JOURNAL ARTICLE
Angelica Ortiz, Hong Sun, Thomas Kluz, Mary S Matsui, Tiffany Carle, David Gan, Terry Gordon, Lucy Gildea, Max Costa
OBJECTIVE: It is well established that exposure of human skin to airborne pollution, particularly in the form of particulate matter sized 2.5 μm (PM2.5 ), is associated with oxidative stress, DNA damage and inflammation, leading to premature signs of skin aging. Because much of the damage results from oxidative stress, we examined the effects of a topical composition containing three antioxidants in an in vitro model system to assess the potential for amelioration of premature aging...
August 21, 2023: International Journal of Cosmetic Science
#25
JOURNAL ARTICLE
Aurelio Vidal-Ortiz, Carlos Blanco-Centurion, Priyattam J Shiromani
To determine how a waking brain falls asleep researchers have monitored and manipulated activity of neurons and glia in various brain regions. While imaging GABA neurons in the zona incerta (ZI) we found a subgroup that anticipates onset of NREM sleep 1. To differentiate the GABA subtype we now image and optogenetically manipulate the ZI neurons containing the transcription factor, Lhx6. In the first study Lhx6-cre mice (n=5; female=4) were given rAAV-DJ-EF1a-DIO-GCaMP6M into the ZI (isofluorane anesthesia), a GRIN lens implanted, and 21d later sleep and fluorescence in individual Lhx6 neurons were recorded for 4h...
August 21, 2023: Sleep
#26
JOURNAL ARTICLE
Monika Pilch, Tijn van Rietschoten, Max Ortiz-Catalan, Eva Lendaro, Corry K van der Sluis, Liselotte Hermansson
PURPOSE: Interpersonal processes, including therapeutic alliance, may modulate the impact of interventions on pain experience. However, the role of interpersonal context on the effects of technology-enhanced interventions remains underexplored. This study elicited therapists' perspectives on how a novel rehabilitative process, involving Phantom Motor Execution (PME), may impact phantom limb pain. The mediating role of therapeutic alliance, and the way PME influenced its formation, was investigated...
2023: Journal of Pain Research
#27
JOURNAL ARTICLE
Lefentse Mashamaite, Pedro H Lebre, Gilda Varliero, Silindile Maphosa, Max Ortiz, Ian D Hogg, Don A Cowan
INTRODUCTION: The Antarctic McMurdo Dry Valleys are geologically diverse, encompassing a wide variety of soil habitats. These environments are largely dominated by microorganisms, which drive the ecosystem services of the region. While altitude is a well-established driver of eukaryotic biodiversity in these Antarctic ice-free areas (and many non-Antarctic environments), little is known of the relationship between altitude and microbial community structure and functionality in continental Antarctica...
2023: Frontiers in Microbiology
#28
JOURNAL ARTICLE
Lisa Van den Broeck, Dinesh Kiran Bhosale, Kuncheng Song, Cássio Flavio Fonseca de Lima, Michael Ashley, Tingting Zhu, Shanshuo Zhu, Brigitte Van De Cotte, Pia Neyt, Anna C Ortiz, Tiffany R Sikes, Jonas Aper, Peter Lootens, Anna M Locke, Ive De Smet, Rosangela Sozzani
Molecular biology aims to understand cellular responses and regulatory dynamics in complex biological systems. However, these studies remain challenging in non-model species due to poor functional annotation of regulatory proteins. To overcome this limitation, we develop a multi-layer neural network that determines protein functionality directly from the protein sequence. We annotate kinases and phosphatases in Glycine max. We use the functional annotations from our neural network, Bayesian inference principles, and high resolution phosphoproteomics to infer phosphorylation signaling cascades in soybean exposed to cold, and identify Glyma...
August 3, 2023: Nature Communications
#29
JOURNAL ARTICLE
Jan Zbinden, Paolo Sassu, Enzo Mastinu, Eric J Earley, Maria Munoz-Novoa, Rickard Brånemark, Max Ortiz-Catalan
Remnant muscles in the residual limb after amputation are the most common source of control signals for prosthetic hands, because myoelectric signals can be generated by the user at will. However, for individuals with amputation higher up the arm, such as an above-elbow (transhumeral) amputation, insufficient muscles remain to generate myoelectric signals to enable control of the lost arm and hand joints, thus making intuitive control of wrist and finger prosthetic joints unattainable. We show that severed nerves can be divided along their fascicles and redistributed to concurrently innervate different types of muscle targets, particularly native denervated muscles and nonvascularized free muscle grafts...
July 12, 2023: Science Translational Medicine
#30
JOURNAL ARTICLE
Ella S Kim, Arjun Rajan, Kathleen Chang, Sanath Govindarajan, Clara Gulick, Eva English, Bianca Rodriguez, Orion Bloomfield, Stella Nakada, Charlotte Beard, Sarah O'Connor, Sophia Mastroianni, Emma Downey, Matthew Feigenbaum, Caitlin Tolentino, Abigail Pace, Marina Khan, Soyoun Moon, Jordan DiPrima, Amber Syed, Flora Lin, Yasmina Abukhadra, Isabella Bacon, John Beckerle, Sophia Cho, Nana Esi Donkor, Lucy Garberg, Ava Harrington, Mai Hoang, Nosa Lawani, Ayush Noori, Euwie Park, Ella Parsons, Philip Oravitan, Matthew Chen, Cristian Molina, Caleb Richmond, Adith Reddi, Jason Huang, Cooper Shugrue, Rose Coviello, Selma Unver, Matthew Indelicarto, Emir Islamovic, Rosemary McIlroy, Alana Yang, Mahdi Hamad, Elizabeth Griffin, Zara Ahmed, Asha Alla, Patricia Fitzgerald, Audrey Choi, Tanya Das, Yuchen Cheng, Joshua Yu, Tabor Roderiques, Ethan Lee, Longchao Liu, Jaekeb Harper, Jason Wang, Chris Suhr, Max Tan, Jacqueline Luque, A Russell Tam, Emma Chen, Max Triff, Lyric Zimmermann, Eric Zhang, Jackie Wood, Kaitlin Clark, Nat Kpodonu, Antar Dey, Alexander Ecker, Maximilian Chuang, Ramón Kodi Suzuki López, Harry Sun, Zijing Wei, Henry Stone, Chia Yu Joy Chi, Aiden Silvestri, Petra Orloff, Neha Nedumaran, Aletheia Zou, Leyla Ünver, Oscair Page, Minseo Kim, Terence Yan Tao Chan, Akili Tulloch, Andrea Hernandez, Aruli Pillai, Caitlyn Chen, Neil Chowdhury, Lina Huang, Anish Mudide, Garrett Paik, Alexandra Wingate, Lily Quinn, Chris Conybere, Luca Laiza Baumgardt, Rollo Buckley, Zara Kolberg, Ruth Pattison, Ashlyn Ahmad Shazli, Pia Ganske, Luca Sfragara, Annina Strub, Barney Collier, Hari Tamana, Dylan Ravindran, James Howden, Madeleine Stewart, Sakura Shimizu, Julia Braniff, Melanie Fong, Lucy Gutman, Danny Irvine, Sahil Malholtra, Jillian Medina, John Park, Alicia Yin, Harrison Abromavage, Breanna Barrett, Jacqueline Chen, Rachelle Cho, Mac Dilatush, Gabriel Gaw, Caitlin Gu, Jupiter Huang, Houston Kilby, Ethan Markel, Katie McClure, William Phillips, Benjamin Polaski, Amelia Roselli, Soleil Saint-Cyr, Ellie Shin, Kylan Tatum, Tai Tumpunyawat, Lucia Wetherill, Sara Ptaszynska, Maddie Zeleznik, Alexander Pesendorfer, Anna Nolan, Jeffrey Tao, Divya Sammeta, Laney Nicholson, Giao Vu Dinh, Merrin Foltz, An Vo, Maggie Ross, Andrew Tokarski, Samika Hariharan, Elaine Wang, Martha Baziuk, Ashley Tay, Yuk Hung Maximus Wong, Jax Floyd, Aileen Cui, Kieran Pierre, Nikita Coppisetti, Matthew Kutam, Dhruv Khurjekar, Anthony Gadzi, Ben Gubbay, Sophia Pedretti, Sofiya Belovich, Tiffany Yeung, Mercy Fey, Layla Shaffer, Arthur Li, Giancarlo Beritela, Kyle Huyghue, Greg Foster, Garrett Durso-Finley, Quinn Thierfelder, Holly Kiernan, Andrew Lenkowsky, Tesia Thomas, Nicole Cheng, Olivia Chao, Pia L'Etoile-Goga, Alexa King, Paris McKinley, Nicole Read, David Milberg, Leila Lin, Melinda Wong, Io Gilman, Samantha Brown, Lila Chen, Jordyn Kosai, Mark Verbinsky, Alice Belshaw-Hood, Honon Lee, Cathy Zhou, Maya Lobo, Asia Tse, Kyle Tran, Kira Lewis, Pratmesh Sonawane, Jonathan Ngo, Sophia Zuzga, Lillian Chow, Vianne Huynh, Wenyi Yang, Samantha Lim, Brandon Stites, Shannon Chang, Raenalyn Cruz-Balleza, Michaela Pelta, Stella Kujawski, Christopher Yuan, Elio Standen-Bloom, Oliver Witt, Karina Anders, Audrey Duane, Nancy Huynh, Benjamin Lester, Samantha Fung-Lee, Melanie Fung, Mandy Situ, Paolo Canigiula, Matijs Dijkgraaf, Wilbert Romero, Samantha Karmela Baula, Kimberly Wong, Ivana Xu, Benjamin Martinez, Reena Nuygen, Lucy Norris, Noah Nijensohn, Naomi Altman, Elise Maajid, Olivia Burkhardt, Jullian Chanda, Catherine Doscher, Alex Gopal, Aaron Good, Jonah Good, Nate Herrera, Lucas Lanting, Sophia Liem, Anila Marks, Emma McLaughlin, Audrey Lee, Collin Mohr, Emma Patton, Naima Pyarali, Claire Oczon, Daniel Richards, Nathan Good, Spencer Goss, Adeeb Khan, Reagan Madonia, Vivian Mitchell, Natasha Sun, Tarik Vranka, Diogo Garcia, Frida Arroyo, Eric Morales, Steven Camey, Giovanni Cano, Angelica Bernabe, Jennifer Arroyo, Yadira Lopez, Emily Gonzalez, Bryan Zumba, Josue Garcia, Esmeralda Vargas, Allen Trinidad, Noel Candelaria, Vanessa Valdez, Faith Campuzano, Emily Pereznegron, Jenifer Medrano, Jonathan Gutierrez, Evelyn Gutierrez, Ericka Taboada Abrego, Dayanara Gutierrez, Cristian Ortiz, Angelica Barnes, Eleanor Arms, Leo Mitchell, Ciara Balanzá, Jake Bradford, Harrison Detroy, Devin Ferguson, Ethel Guillermo, Anusha Manapragada, Daniella Nanula, Brigitte Serna, Khushi Singh, Emily Sramaty, Brian Wells, Matthew Wiggins, Melissa Dowling, Geraldine Schmadeke, Samantha Cafferky, Stephanie Good, Margaret Reese, Miranda Fleig, Alex Gannett, Cory Cain, Melody Lee, Paul Oberto, Jennifer Rinehart, Elaine Pan, Sallie Anne Mathis, Jessica Joiner, Leslie Barr, Cory J Evans, Alberto Baena-Lopez, Andrea Beatty, Jeanette Collette, Robert Smullen, Jeanne Suttie, Townley Chisholm, Cheryl Rotondo, Gareth Lewis, Victoria Turner, Lloyd Stark, Elizabeth Fox, Anjana Amirapu, Sangbin Park, Nicole Lantz, Anne E Rankin, Seung K Kim, Lutz Kockel
Conditional gene regulation in Drosophila through binary expression systems like the LexA-LexAop system provides a superb tool for investigating gene and tissue function. To increase the availability of defined LexA enhancer trap insertions, we present molecular, genetic and tissue expression studies of 301 novel Stan-X LexA enhancer traps derived from mobilization of the index SX4 line. This includes insertions into distinct loci on the X, II and III chromosomes that were not previously associated with enhancer traps or targeted LexA constructs, an insertion into ptc, and seventeen insertions into natural transposons...
June 6, 2023: G3: Genes—Genomes—Genetics
#31
JOURNAL ARTICLE
Sinan Arslan, Francisco J Garcia, Minghao Guo, Matthew W Kellinger, Semyon Kruglyak, Jake A LeVieux, Adeline H Mah, Haosen Wang, Junhua Zhao, Chunhong Zhou, Andrew Altomare, John Bailey, Matthew B Byrne, Chiting Chang, Steve X Chen, Byungrae Cho, Claudia N Dennler, Vivian T Dien, Derek Fuller, Ryan Kelley, Omid Khandan, Michael G Klein, Michael Kim, Bryan R Lajoie, Bill Lin, Yu Liu, Tyler Lopez, Peter T Mains, Andrew D Price, Samantha R Robertson, Hermes Taylor-Weiner, Ramreddy Tippana, Austin B Tomaney, Su Zhang, Minna Abtahi, Mark R Ambroso, Rosita Bajari, Ava M Bellizzi, Chris B Benitez, Daniel R Berard, Lorenzo Berti, Kelly N Blease, Angela P Blum, Andrew M Boddicker, Leo Bondar, Chris Brown, Chris A Bui, Juan Calleja-Aguirre, Kevin Cappa, Joshua Chan, Victor W Chang, Katherine Charov, Xiyi Chen, Rodger M Constandse, Weston Damron, Mariam Dawood, Nicole DeBuono, John D Dimalanta, Laure Edoli, Keerthana Elango, Nikka Faustino, Chao Feng, Matthew Ferrari, Keith Frankie, Adam Fries, Anne Galloway, Vlad Gavrila, Gregory J Gemmen, James Ghadiali, Arash Ghorbani, Logan A Goddard, Adriana Roginski Guetter, Garren L Hendricks, Jendrik Hentschel, Daniel J Honigfort, Yun-Ting Hsieh, Yu-Hsien Hwang Fu, Scott K Im, Chaoyi Jin, Shradha Kabu, Daniel E Kincade, Shawn Levy, Yu Li, Vincent K Liang, William H Light, Jonathan B Lipsher, Tsung-Li Liu, Grace Long, Rui Ma, John M Mailloux, Kyle A Mandla, Anyssa R Martinez, Max Mass, Daniel T McKean, Michael Meron, Edmund A Miller, Celyne S Moh, Rachel K Moore, Juan Moreno, Jordan M Neysmith, Cassandra S Niman, Jesus M Nunez, Micah T Ojeda, Sara Espinosa Ortiz, Jenna Owens, Geoffrey Piland, Daniel J Proctor, Josua B Purba, Michael Ray, Daisong Rong, Virginia M Saade, Sanchari Saha, Gustav Santo Tomas, Nicholas Scheidler, Luqmanal H Sirajudeen, Samantha Snow, Gudrun Stengel, Ryan Stinson, Michael J Stone, Keoni J Sundseth, Eileen Thai, Connor J Thompson, Marco Tjioe, Christy L Trejo, Greg Trieger, Diane Ni Truong, Ben Tse, Benjamin Voiles, Henry Vuong, Jennifer C Wong, Chiung-Ting Wu, Hua Yu, Yingxian Yu, Ming Yu, Xi Zhang, Da Zhao, Genhua Zheng, Molly He, Michael Previte
We present avidity sequencing, a sequencing chemistry that separately optimizes the processes of stepping along a DNA template and that of identifying each nucleotide within the template. Nucleotide identification uses multivalent nucleotide ligands on dye-labeled cores to form polymerase-polymer-nucleotide complexes bound to clonal copies of DNA targets. These polymer-nucleotide substrates, termed avidites, decrease the required concentration of reporting nucleotides from micromolar to nanomolar and yield negligible dissociation rates...
May 25, 2023: Nature Biotechnology
#32
JOURNAL ARTICLE
Evelin Martinez, Ryan Max, Filemón Bucardo, Elizabeth M Stringer, Sylvia Becker-Dreps, Christian Toval-Ruíz, Meylin Chavarria, María J Meléndez-Balmaceda, Carlos Nuñez, Matthew H Collins, Michael Boivin, Shiara Ortiz-Pujols, Omar Zepeda, Kaitlyn Cross, Emily W Gower, Natalie M Bowman, Sara F Grace
Knowledge regarding the frequency of ocular abnormalities and abnormal visual function in children exposed to Zika virus (ZIKV) in utero but born without congenital Zika syndrome (CZS) is limited. We hypothesized that children exposed to ZIKV in utero born without CZS may have visual impairments in early childhood. We performed ophthalmic examination between 16 and 21 months of age and neurodevelopment assessment at 24 months of age with the Mullen Scales of Early Learning test (MSEL) on children enrolled in a cohort born to women pregnant during and shortly after the ZIKV epidemic in Nicaragua (2016-2017)...
May 19, 2023: PLoS Neglected Tropical Diseases
#33
JOURNAL ARTICLE
Anna Björkquist, Li Guo, Morten B Kristoffersen, Maria M Novoa, Max Ortiz-Catalan, Leif Sandsjö
This case study reports the use of a new textile-electrode system for self-administered Phantom Motor Execution (PME) treatment at home in one patient with Phantom Limb Pain (PLP). In follow-up interviews, the patient reported reduced pain, increased mobility, and improved mental health, and aspects such as motivation, usability, support, and treatment outcome, could be recognized from an earlier study as crucial for successful implementation and adoption of the home-based long-term treatment. The findings are of interest to developers, providers, users, and researchers planning home-based clinical studies and/or scenarios based on technology-assisted treatment...
May 18, 2023: Studies in Health Technology and Informatics
#34
JOURNAL ARTICLE
Emily Pettersen, Paolo Sassu, Carina Reinholdt, Peter Dahm, Ola Rolfson, Anders Björkman, Marco Innocenti, Francesca Alice Pedrini, Juan Manuel Breyer, Aidan Roche, Andrew Hart, Lorraine Harrington, Adil Ladak, Hollie Power, Jacqueline Hebert, Max Ortiz-Catalan
BACKGROUND: Painful conditions such as residual limb pain (RLP) and phantom limb pain (PLP) can manifest after amputation. The mechanisms underlying such postamputation pains are diverse and should be addressed accordingly. Different surgical treatment methods have shown potential for alleviating RLP due to neuroma formation - commonly known as neuroma pain - and to a lesser degree PLP. Two reconstructive surgical interventions, namely targeted muscle reinnervation (TMR) and regenerative peripheral nerve interface (RPNI), are gaining popularity in postamputation pain treatment with promising results...
May 2, 2023: Trials
#35
JOURNAL ARTICLE
Mirka Buist, Shahrzad Damercheli, Minh T N Truong, Alessio Sanna, Enzo Mastinu, Max Ortiz-Catalan
Training sensory discrimination of the skin has the potential to reduce chronic pain due to sensorimotor impairments and increase sensorimotor function. Currently, there is no such device that can systematically provide rich skin stimulation suitable for a training protocol for individuals with amputation or major sensory impairment. This study describes the development and validation of a non-invasive wearable device meant to repeatedly and safely deliver somatosensory stimulations. The development was guided by a structured design control process to ensure the verifiability and validity of the design outcomes...
May 1, 2023: IEEE Transactions on Biomedical Circuits and Systems
#36
REVIEW
Stella M Hartinger, Marisol Yglesias-González, Luciana Blanco-Villafuerte, Yasna K Palmeiro-Silva, Andres G Lescano, Anna Stewart-Ibarra, David Rojas-Rueda, Oscar Melo, Bruno Takahashi, Daniel Buss, Max Callaghan, Francisco Chesini, Elaine C Flores, Carolina Gil Posse, Nelson Gouveia, Slava Jankin, Zaray Miranda-Chacon, Nahid Mohajeri, Juliana Helo, Laura Ortiz, Chrissie Pantoja, Maria Fernanda Salas, Raquel Santiago, Milena Sergeeva, Tatiana Souza de Camargo, Armando Valdés-Velásquez, Maria Walawender, Marina Romanello
No abstract text is available yet for this article.
April 2023: Lancet Reg Health Am
#37
JOURNAL ARTICLE
Andrew Pearson, Camila Ortiz, Max Eisenbaum, Clara Arrate, Mackenzie Browning, Michael Mullan, Corbin Bachmeier, Fiona Crawford, Joseph O Ojo
Traumatic brain injury is a leading cause of morbidity and mortality in adults and children in developed nations. Following the primary injury, microglia, the resident innate immune cells of the CNS, initiate several inflammatory signaling cascades and pathophysiological responses that may persist chronically; chronic neuroinflammation following TBI has been closely linked to the development of neurodegeneration and neurological dysfunction. Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that have been shown to regulate several key mechanisms in the inflammatory response to TBI...
April 20, 2023: Molecular and Cellular Neurosciences
#38
JOURNAL ARTICLE
Victoria Ashley Lang, Maria Munoz-Novoa, Max Ortiz-Catalan
Residual limbs after amputation present colder temperatures than unaffected contralateral limbs. This temperature asymmetry has been attributed to autonomic and cognitive factors, such as changes in body representation. An ideal limb replacement should restore the body representation and resolve the temperature asymmetry, but conventional prostheses, commonly characterized as disembodied, fail to do so. Neuromusculoskeletal prostheses are a new concept of artificial limbs that directly interface with the user's nerves, muscles, and skeleton, and are operated in daily life by bidirectionally transferring control and somatosensory information...
April 17, 2023: Scientific Reports
#39
JOURNAL ARTICLE
Paulina González-González, Saúl Gómez-Manzo, Araceli Tomasini, José Luis Martínez Y Pérez, Edelmira García Nieto, Arely Anaya-Hernández, Elvia Ortiz Ortiz, Rosa Angélica Castillo Rodríguez, Jaime Marcial-Quino, Alba Mónica Montiel-González
Laccases are valuable enzymes as an excellent ecological alternative for bioremediation issues because they can oxidize persistent xenobiotic compounds. The production and characterization of extracellular laccases from saprotrophic fungi from disturbed environments have been scarcely explored, even though this could diversify their functional characteristics and expand the conditions in which they carry out their catalysis. Agrocybe pediades , isolated from a disturbed forest, produces an extracellular laccase in liquid culture...
February 24, 2023: Microorganisms
#40
JOURNAL ARTICLE
T Pumarola, J Díez-Domingo, F Martinón-Torres, E Redondo Margüello, R Ortiz de Lejarazu Leonardo, M Carmo, G Bizouard, G Drago, J L López-Belmonte, H Bricout, C de Courville, A Gil-de-Miguel
BACKGROUND: Influenza may trigger complications, particularly in at-risk groups, potentially leading to hospitalization or death. However, due to lack of routine testing, influenza cases are infrequently coded with influenza-specific diagnosis. Statistical models using influenza activity as an explanatory variable can be used to estimate annual hospitalizations and deaths associated with influenza. Our study aimed to estimate the clinical and economic burden of severe influenza in Spain, considering such models...
February 7, 2023: BMC Infectious Diseases
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