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https://www.readbyqxmd.com/read/29222932/a-fibers-mediate-cold-hyperalgesia-in-patients-with-oxaliplatin-induced-neuropathy
#1
Julia Forstenpointner, Violetta C Oberlojer, Dennis Naleschinski, Johanna Höper, Stephanie M Helfert, Andreas Binder, Janne Gierthmühlen, Ralf Baron
Cold hyperalgesia is a common side effect of oxaliplatin treatment; still the pathophysiological and molecular mechanisms as well as the contribution of different primary afferent fiber systems are unclear. Therefore, patients with oxaliplatin-induced acute neuropathy with (n=6) and without (n=7) cold hyperalgesia were tested by applying a preferential blockade of peripheral myelinated A-fiber afferents in combination with quantitative sensory testing. Additionally, an interview-based questionnaire assessed the severity of symptoms and the impact on daily activities...
December 9, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29222405/multiple-weekly-dalbavancin-dosing-for-the-treatment-of-native-vertebral-osteomyelitis-caused-by-methicillin-resistant-staphylococcus-aureus-a-case-report
#2
Thamer A Almangour, Valerie Fletcher, Mohammed Alessa, Abdullah A Alhifany, Deanne Tabb
BACKGROUND Native vertebral osteomyelitis (NVO) is a common form of hematogenous osteomyelitis, with Staphylococcus aureus (S. aureus) being the most commonly isolated organism. Dalbavancin is approved by the US Food and Drug Administration (FDA) for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and has a sufficiently promising pharmacokinetic and pharmacodynamic profile to be considered for the treatment of vertebral osteomyelitis. We describe here what is probably the first reported case of using multiple weekly dalbavancin to treat a complicated methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and vertebral osteomyelitis...
December 9, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29222315/extracorporeal-photopheresis-cellular-therapy-for-the-treatment-of-acute-and-chronic-graft-versus-host-disease
#3
REVIEW
Jennifer Schneiderman
Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative option for many disease states. Despite significant improvements in strategies used to prevent and treat acute and chronic graft-versus-host disease (a/cGVHD), they continue to negatively affect outcomes of HSCT significantly. Standard, first-line treatment consists of corticosteroids; beyond this, there is little consistency in therapeutic regimens. Current options include the addition of various immunosuppressive agents, the use of which puts patients at even higher risks for infection and other morbidities...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29221836/efficacy-versus-complications-in-arterial-thrombolysis
#4
H P Ebben, M V van Burink, V Jongkind, D E Mouwen, J Udding, W Wisselink, J K Kievit, A M Wiersema, K K Yeung
BACKGROUND: Acute peripheral arterial occlusions threaten life and limb. Thrombolysis is an established, minimally invasive alternative treatment for surgical thromboembolectomy. Yet, there is no consensus regarding an optimal thrombolysis protocol and current knowledge is largely based on studies from the 1990's. This study reviews a contemporary cohort of patients treated with thrombolysis and aims to evaluate the treatment results and to identify possible predictors for outcome and (bleeding) complications...
December 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29221470/potential-diagnostic-markers-of-olanzapine-efficiency-for-acute-psychosis-a-focus-on-peripheral-biogenic-amines
#5
A E Taraskina, R F Nasyrova, A M Zabotina, D N Sosin, К А Sosina, E E Ershov, M N Grunina, E M Krupitsky
BACKGROUND: Biomarkers are now widely used in many fields of medicine, and the identification of biomarkers that predict antipsychotic efficacy and adverse reactions is a growing area of psychiatric research. Monoamine molecules of the peripheral bloodstream are possible prospective biomarkers based on a growing body of evidence indicating that they may reflect specific changes in neurotransmitters in the brain. The aim of this study was to detect peripheral biogenic amine indicators of patients with acute psychosis and to test the correlations between the biological measures studied and the psychopathological status of the patients...
December 8, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29221427/validity-of-the-dutch-modified-paindetect-questionnaire-for-patients-with-hip-or-knee-osteoarthritis
#6
Wietske Rienstra, Tim Blikman, Baukje Dijkstra, Jos van Raay, Geranda Slager, Sjoerd Bulstra, Martin Stevens, Inge van den Akker-Scheek
BACKGROUND: The modified painDETECT questionnaire (PDQ) is a self-reported questionnaire to discriminate between nociceptive and neuropathic-like pain in patients with knee/hip osteoarthritis (OA). This study aims to assess the structural and construct validity of this questionnaire. METHODS: Confirmatory factor analysis and hypothesis-testing was used. For 168 patients, predefined hypotheses were formulated on the correlation between the modified painDETECT and several other questionnaires, and in a subsample of 46 with pain pressure thresholds (PPTs)...
December 8, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29221329/inter-hospital-transports-on-extracorporeal-membrane-oxygenation-in-different-health-care-systems
#7
Lars Mikael Broman
The feasibility and the recognition of the possibility to transport patients on extracorporeal membrane oxygenation (ECMO) aroused in the 1970s. The number of transporting facilities worldwide was less than 20 in the beginning of the second Millennium. In 2009 the H1N1 pandemic and a publication showing survival benefit for adult patients transported to a hospital with ECMO resource increased both awareness and interest for ECMO treatment. The number of transport organizations increased rapidly. As of today, the number of transport organizations increases world-wide, though some centers where ECMO is an established treatment report decreasing numbers of transports...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29220591/cholinergic-and-cytoprotective-signaling-cascades-mediate-the-mitigative-effect-of-erythropoietin-on-acute-radiation-syndrome
#8
Shereen Mohamed Galal, Mohamed Khairy Abdel-Rafei, Hesham Hasan
The present investigation aimed to evaluate the radiomitigative efficacy of the recombinant human erythropoietin (rhEPO) against acute radiation syndrome (ARS) in a rat model. Rats were irradiated with a single sublethal dose of γ- radiation (7 Gy; total body irradiation; TBI) at the 1st day of experimental course, then received EPO (5000 IU/kg; i.p) 24 hrs post irradiation, rats were observed for 30 days of survival analysis. Administration of EPO improved 30 days survival, alleviated TBI- induced myelosuppression and pancytopenia, by augmenting lymphocytes and WBCs in the peripheral blood of rats, while bone marrow (BM) and spleen cellularity were restored...
December 8, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29220302/biology-and-management-of-undifferentiated-pleomorphic-sarcoma-myxofibrosarcoma-and-malignant-peripheral-nerve-sheath-tumors-state-of-the-art-and-perspectives
#9
Brigitte C Widemann, Antoine Italiano
Undifferentiated pleomorphic sarcomas, myxofibrosarcomas, and malignant peripheral nerve sheath tumors are characterized by complex genomic characteristics and aggressive clinical behavior. Recent advances in the understanding of the pathogenesis of these tumors may allow for the development of more-effective innovative therapeutic strategies, including immunotherapies. This review describes the current knowledge of the epidemiology, clinical presentation, treatment, and pathogenesis of these tumors and highlights ongoing and future research...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29219049/role-of-mitochondrial-mechanism-in-chemotherapy-induced-peripheral-neuropathy
#10
Mohammad Waseem, Pooja Kaushik, Heena Tabassum, Suhel Parvez
BACKGROUND: Even though chemotherapeutic regimens shows considerable importance, it may cause progressive, continuing and sometimes irreversible peripheral neuropathy. Chemotherapy induced peripheral neuropathy (CIPN) comprises of sensory abnormalities that are most distress issues. The mechanism associated with CIPN pathogenesis is not completely revealed and is treatment is still questionable. The purpose of this review was to investigate the role of mitochondria in CIPN. METHODS: This review is literature based that describes the mitochondrial mechanism underlying CIPN and the neuropathic complications associated with different antineoplastic agents...
December 7, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29219025/the-effect-of-growth-hormone-on-chondral-defect-repair
#11
Natalie R Danna, Bryan G Beutel, Austin J Ramme, Thorsten Kirsch, Oran D Kennedy, Eric Strauss
Objective Focal chondral defects alter joint mechanics and cause pain and debilitation. Microfracture is a surgical technique used to treat such defects. This technique involves penetration of subchondral bone to release progenitor cells and growth factors from the marrow to promote cartilage regeneration. Often this results in fibrocartilage formation rather than structured hyaline cartilage. Some reports have suggested use of growth hormone (GH) with microfracture to augment cartilage regeneration. Our objective was to test whether intra-articular (IA) GH in conjunction with microfracture, improves cartilage repair in a rabbit chondral defect model...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29218656/multipath-curved-planar-reformations-of-peripheral-ct-angiography-diagnostic-accuracy-and-time-efficiency
#12
Markus M Schreiner, Hannes Platzgummer, Sylvia Unterhumer, Michael Weber, Gabriel Mistelbauer, Eduard Groeller, Christian Loewe, Ruediger E Schernthaner
OBJECTIVES: To compare diagnostic performance and time efficiency between 3D multipath curved planar reformations (mpCPRs) and axial images of CT angiography for the pre-interventional assessment of peripheral arterial disease (PAD), with digital subtraction angiography as the standard of reference. METHODS: Forty patients (10 females, mean age 72 years), referred to CTA prior to endovascular treatment of PAD, were prospectively included and underwent peripheral CT angiography...
December 7, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29218644/cardiovascular-complications-of-marijuana-and-related-substances-a-review
#13
REVIEW
Amitoj Singh, Sajeev Saluja, Akshat Kumar, Sahil Agrawal, Munveer Thind, Sudip Nanda, Jamshid Shirani
The recreational use of cannabis has sharply increased in recent years in parallel with its legalization and decriminalization in several countries. Commonly, the traditional cannabis has been replaced by potent synthetic cannabinoids and cannabimimetics in various forms. Despite overwhelming public perception of the safety of these substances, an increasing number of serious cardiovascular adverse events have been reported in temporal relation to recreational cannabis use. These have included sudden cardiac death, vascular (coronary, cerebral and peripheral) events, arrhythmias and stress cardiomyopathy among others...
December 7, 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/29218423/early-intraocular-pressure-change-after-peripheral-iridotomy-with-ultralow-fluence-pattern-scanning-laser-and-nd-yag-laser-in-primary-angle-closure-suspect-kowloon-east%C3%A2-pattern-scanning-laser-study-report-no-3
#14
Jeffrey Chi Wang Chan, Bonnie Nga Kwan Choy, Orlando Chia Chieh Chan, Kenneth Kai Wang Li
PURPOSE: Our purpose was to assess the early intraocular pressure (IOP) changes of ultralow fluence laser iridotomy using pattern scanning laser followed by neodymium:yttrium-aluminum-gamet (Nd:YAG) laser. METHODS: This is a prospective interventional study. Thirty-three eyes of 33 adult Chinese primary angle-closure suspect subjects were recruited for prophylactic laser peripheral iridotomy. Sequential laser peripheral iridotomy was performed using pattern scanning laser followed by Nd:YAG laser...
December 7, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29218050/heme-drives-oxidative-stress-associated-cell-death-in-human-neutrophils-infected-with-leishmania-infantum
#15
Graziele Quintela-Carvalho, Nívea F Luz, Fabiana S Celes, Dalila L Zanette, Daniela Andrade, Diego Menezes, Natália M Tavares, Claudia I Brodskyn, Deboraci B Prates, Marilda S Gonçalves, Camila I de Oliveira, Roque P Almeida, Marcelo T Bozza, Bruno B Andrade, Valeria M Borges
Free heme is an inflammatory molecule capable of inducing migration and activation of neutrophils. Here, we examine the heme-driven oxidative stress-associated cell death mechanisms in human neutrophils infected with Leishmania infantum, an etiologic agent of visceral leishmaniasis (VL). We first performed exploratory analyses in a population of well characterized treatment-naïve VL patients as well as uninfected controls, who were part of previously reported studies. We noted a positive correlation between serum concentrations of heme with heme oxygenase-1 (HO-1) and lactate deydrogenase, as well as, a negative correlation between heme values and peripheral blood neutrophils counts...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29217950/agreement-between-direct-fluorescent-microscopy-and-ziehl-neelsen-concentration-techniques-in-detection-of-pulmonary-tuberculosis-in-northwest-ethiopia
#16
Meseret Workineh, Mandie Maru, Ibrahim Seman, Ziyadu Bezu, Markos Negash, Mulugeta Melku, Addisu Gize, Agumas Shibabaw
Background: The sensitivity of smear microscopy for diagnosis of tuberculosis might be improved through treatment of sputum with sodium hypochlorite and application of fluorescent microscopy. This study aimed to determine the agreement between direct Fluorescent Microscopy and Ziehl-Neelsen concentration technique by their ability of detecting acid fast bacilli in resource poor settings. Methods: A cross sectional study was conducted at Gondar University Referral Hospital, Northwest Ethiopia...
September 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217947/coexistence-of-peripheral-spondyloarthritis-and-familial-adenomatous-polyposis-a-rare-case-report-with-treatment-contradictions-and-review-of-the-literature
#17
Berna Urkmez, Muge Kepekci, Sevde Ozer Posul, Aylin Rezvani
Background: The coexistence of familial adenomatous polyposis and spondyloarthritis is rarely defined in literature. The primary aim of this presentation is to report a development of peripheral arthritis in 3 years following colon surgery with the diagnosis of familial adenomatous polyposis (FAP). The secondary aim is to discuss the challenge of in treatment of refractory arthritis, which needs to be treated with biologics. However, it is not yet known well about their safety on patients who have risks for cancer development...
July 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217500/peripheral-neuropathy-as-a-complication-of-diabetic-ketoacidosis-in-a-child-with-newly-diagnosed-diabetes-type-1-case-report
#18
Marta Baszyńska-Wilk, Marta Wysocka-Mincewicz, Anna Świercz, Jolanta Świderska, Magdalena Marszał, Mieczysław Szalecki
BACKGROUND: Neurological complications of diabetic ketoacidosis are considered to be very serious clinical problem. The most common complication is cerebral edema. However this group includes also less common syndromes such as ischemic or hemorrhagic stroke, cerebral venous and sinus thrombosis or very rare peripheral neuropathy. CASE REPORT: We present a case of 9-year old girl with new onset type 1 diabetes, diabetic ketoacidosis, cerebral edema, multifocal vasogenic brain lesions and lower limbs peripheral paresis...
December 8, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29217441/impact-of-bmi-on-outcomes-after-mesenteric-revascularization-for-chronic-mesenteric-ischemia
#19
Neel A Mansukhani, Katherine E Hekman, Dustin Y Yoon, Irene B Helenowski, Andrew W Hoel, Heron E Rodriguez, William H Pearce, Mark K Eskandari, Tadaki M Tomita
OBJECTIVE: Historically, patients with chronic mesenteric ischemia (CMI) are underweight with a low body mass index (BMI). However, with the recent obesity epidemic many of these patients now are overweight with a high BMI. We evaluated the impact of BMI on outcomes after mesenteric revascularization for CMI. METHODS: A retrospective chart review of patients undergoing open or endovascular mesenteric revascularization for CMI between January 2000 and June 2015 was performed...
December 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29217435/determination-of-risk-factors-and-establishment-of-a-prediction-model-for-immediate-technical-failure-during-endovascular-treatment-of-femoropopliteal-occlusive-disease
#20
Yi-Hui Qiu, Guan-Feng Yu, Huan-Hao Zhou, Hu-Wei Xia, Li Chen, Hao-Tian Chen, Yuan-Yong Jiao, Zi-Heng Wu, Xiang-Tao Zheng
PURPOSE: This study aims to reveal risk factors and establish a prediction model for the immediate technical failure (ITF) of endovascular treatment (EVT) in femoropopliteal occlusive disease (FPOD) patients based on preoperative clinical data. METHODS: A retrospective analysis of 1563 FPOD patients who underwent above-the-knee EVT was undertaken. Univariate analysis with Chi-square test was used to screen risk factors from preoperative clinical data. Multivariable analysis with logistic regression was used to generate a model for predicting the ITF rate of EVT, which was evaluated through the receiver operator characteristic curve and another independent cohort of 242 FPOD patients...
December 4, 2017: Annals of Vascular Surgery
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