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https://www.readbyqxmd.com/read/29933273/spinal-activation-of-tropomyosin-receptor-kinase-b-recovers-the-impaired-endogenous-analgesia-in-neuropathic-pain-rats
#1
Daiki Kato, Takashi Suto, Hideaki Obata, Shigeru Saito
BACKGROUND: Although endogenous analgesia plays an important role in controlling pain states, chronic pain patients exhibit decreased endogenous analgesia compared to healthy individuals. In rats, noxious stimulus-induced analgesia (NSIA), which is an indicator of endogenous analgesia, diminished 6 weeks after spinal nerve ligation (SNL6W). A recent study in rats with deleted noradrenergic fibers demonstrated that the noradrenergic fibers were essential to NSIA. It has also been reported that brain-derived neurotrophic factor increased spinal noradrenergic fibers...
June 20, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29930550/neuroimmunology-of-behavioral-comorbidities-associated-with-cancer-and-cancer-treatments
#2
REVIEW
Jessica C Santos, Leah M Pyter
Behavioral comorbidities (depression, anxiety, fatigue, cognitive disturbances, and neuropathic pain) are prevalent in cancer patients and survivors. These mental and neurological health issues reduce quality-of-life, which is a significant societal concern given the increasing rates of long-term survival after various cancers. Hypothesized causes of behavioral comorbidities with cancer include tumor biology, stress associated with the cancer experience, and cancer treatments. A relatively recent leading mechanism by which these causes contribute to changes in neurobiology that underlie behavior is inflammation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29930510/%C3%AE-2-and-%C3%AE-2-adrenoreceptor-mediated-efficacy-of-the-atypical-antidepressant-agomelatine-combined-with-gabapentin-to-suppress-allodynia-in-neuropathic-rats-with-ligated-infraorbital-or-sciatic-nerve
#3
Saïd M'Dahoma, Matthieu Poitevin, Eric Dabala, Hugo Payan, Cecilia Gabriel, Elisabeth Mocaër, Sylvie Bourgoin, Michel Hamon
Previous data showed that neuropathic pain induced by mechanical lesion of peripheral nerves has specific characteristics and responds differently to alleviating drugs at cephalic versus extracephalic level. This is especially true for tricyclic antidepressants currently used for alleviating neuropathic pain in humans which are less effective against cephalic neuropathic pain. Whether this also applies to the antidepressant agomelatine, with its unique pharmacological properties as MT1 /MT2 melatonin receptor agonist and 5-HT2B /5-HT2C serotonin receptor antagonist, has been investigated in two rat models of neuropathic pain...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29930500/epigenetic-modifications-associated-to-neuroinflammation-and-neuropathic-pain-after-neural-trauma
#4
REVIEW
Clara Penas, Xavier Navarro
Accumulating evidence suggests that epigenetic alterations lie behind the induction and maintenance of neuropathic pain. Neuropathic pain is usually a chronic condition caused by a lesion, or pathological change, within the nervous system. Neuropathic pain appears frequently after nerve and spinal cord injuries or diseases, producing a debilitation of the patient and a decrease of the quality of life. At the cellular level, neuropathic pain is the result of neuronal plasticity shaped by an increase in the sensitivity and excitability of sensory neurons of the central and peripheral nervous system...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29929594/diagnosis-and-management-of-neuropathic-itch
#5
REVIEW
Jordan Daniel Rosen, Anna Chiara Fostini, Gil Yosipovitch
Neuropathic pruritus is a challenging condition that can be caused by injury or dysfunction in any part of the nervous system. A vast array of clinical pictures exist, including both localized and generalized pruritus, and their principal entities are described in this article. Diagnosis is often difficult and depends on patient history, imaging, and neurophysiologic studies. Other causes of chronic itch should be excluded. The management of neuropathic itch is demanding and the majority of interventions are not curative...
July 2018: Dermatologic Clinics
https://www.readbyqxmd.com/read/29929563/procyanidins-attenuate-neuropathic-pain-by-suppressing-matrix-metalloproteinase-9-2
#6
Cailong Pan, Chaoyu Wang, Li Zhang, Ling Song, Yuan Chen, Bingqian Liu, Wen-Tao Liu, Liang Hu, Yinbing Pan
BACKGROUND: Management of neuropathic pain is a real clinical challenge. Despite intense investigation, the mechanisms of neuropathic pain remain substantially unidentified. Matrix metalloproteinase (MMP)-9 and MMP-2 have been reported to contribute to the development and maintenance of neuropathic pain. Therefore, inhibition of MMP-9/2 may provide a novel therapeutic approach for the treatment of neuropathic pain. In this study, we aim to investigate the effect of procyanidins (PC), clinically used health product, on MMP-9/2 in neuropathic pain...
June 21, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29929349/neuropathic-cancer-pain-prevalence-pathophysiology-and-management
#7
So Young Yoon, Jeeyoung Oh
Neuropathic cancer pain (NCP) is caused by nerve damage attributable to the cancer per se, and/or treatments including chemotherapy, radiotherapy, and surgery; the prevalence is reported to be as high as 40%. The etiologies of NCP include direct nerve invasion or nerve compression by the cancer, neural toxicity, chemotherapy, and radiotherapy. NCP is subdivided into plexopathy, radiculopathy, and peripheral neuropathies, among several other categories. The clinical characteristics of NCP differ from those of nociceptive pain in terms of both the hypersensitivity symptoms (burning, tingling, and an electrical sensation) and the hyposensitivity symptoms (numbness and muscle weakness)...
June 25, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29928964/spinal-interleukin-10-produces-antinociception-in-neuropathy-through-microglial-%C3%AE-endorphin-expression-separated-from-antineuroinflammation
#8
Hai-Yun Wu, Xiao-Fang Mao, Xue-Qi Tang, Usman Ali, Evhy Apryani, Hao Liu, Xin-Yan Li, Yong-Xiang Wang
Interleukin 10 (IL-10) is antinociceptive in various animal models of pain without induction of tolerance, and its mechanism of action was generally believed to be mediated by inhibition of neuroinflammation. Here we reported that intrathecal IL-10 injection dose dependently attenuated mechanical allodynia and thermal hyperalgesiain male and female neuropathic rats, with ED50 values of 40.8 ng and 24 ng, and Emax values of 61.5% MPE and 100% MPE in male rats. Treatment with IL-10 specifically increased expression of the β-endorphin (but not prodynorphin) gene and protein in primary cultures of spinal microglia but not in astrocytes or neurons...
June 18, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29928003/elevated-galanin-receptor-type-2-primarily-contributes-to-mechanical-hypersensitivity-after-median-nerve-injury
#9
Seu-Hwa Chen, June-Horng Lue, Yung-Jung Hsiao, Shu-Mei Lai, Hsin-Ying Wang, Chi-Te Lin, Ya-Chin Chen, Yi-Ju Tsai
In this study, we investigated temporal changes in galanin receptor type 2 (GalR2) expression in NF200-, galanin-, neuropeptide Y (NPY)-, and neuronal nitric oxide synthase (nNOS)-like immunoreactive (LI) dorsal root ganglion (DRG) neurons after median nerve chronic constriction injury (CCI), and the effects of GalR2 on c-Fos expression in the cuneate nucleus (CN). Double immunofluorescence labeling methods were used to appraise changes in GalR2 expression in NF200-LI, galanin-LI, NPY-LI, and nNOS-LI DRG neurons after CCI...
2018: PloS One
https://www.readbyqxmd.com/read/29926144/lappaconitine-a-c18-diterpenoid-alkaloid-exhibits-antihypersensitivity-in-chronic-pain-through-stimulation-of-spinal-dynorphin-a-expression
#10
Ming-Li Sun, Jun-Ping Ao, Yi-Rui Wang, Qian Huang, Teng-Fei Li, Xin-Yan Li, Yong-Xiang Wang
Lappaconitine is a representative C18-diterpenoid alkaloid extracted from Aconitum sinomontanum Nakai and has been prescribed as a pain relief medicine in China for more than 30 years. This study evaluated its antihypersensitivity activity in the rat models of neuropathic and cancer pains and explored its underlying mechanisms. Subcutaneous injection of cumulative doses of lappaconitine produced dose-dependent mechanical antiallodynia and thermal antihyperalgesia in spinal nerve ligation-induced neuropathic rats...
June 20, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29925650/optogenetic-inhibition-of-cgrp%C3%AE-sensory-neurons-reveals-their-distinct-roles-in-neuropathic-and-incisional-pain
#11
Ashley M Cowie, Francie Moehring, Crystal O'Hara, Cheryl L Stucky
Cutaneous somatosensory neurons convey innocuous and noxious mechanical, thermal, and chemical stimuli from peripheral tissues to the CNS. Among these are nociceptive neurons that express calcitonin gene-related peptide-α (CGRPα). The role of peripheral CGRPα neurons (CANs) in acute and injury-induced pain has been studied using diphtheria toxin ablation, but their functional roles remain controversial. Because ablation permanently deletes a neuronal population, compensatory changes may ensue that mask the physiological or pathophysiological roles of CANs, particularly for injuries that occur after ablation...
June 20, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29923456/transcription-independent-expression-of-pkm%C3%AE-in-the-anterior-cingulate-cortex-contributes-to-chronically-maintained-neuropathic-pain
#12
Hyoung-Gon Ko, Sanghyun Ye, Dae-Hee Han, Pojeong Park, Chae-Seok Lim, Kyungmin Lee, Min Zhuo, Bong-Kiun Kaang
Protein kinase M ζ is well known for its role in maintaining memory and pain. Previously, we revealed that the activation of protein kinase M ζ in the anterior cingulate cortex plays a role in sustaining neuropathic pain. However, the mechanism by which protein kinase M ζ is expressed in the anterior cingulate cortex by peripheral nerve injury, and whether blocking of protein kinase M ζ using its inhibitor, zeta inhibitory peptide, produces analgesic effects in neuropathic pain maintained chronically after injury, have not previously been resolved...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29923025/cannabinoids-for-treatment-of-ms-symptoms-state-of-the-evidence
#13
REVIEW
Jessica Rice, Michelle Cameron
PURPOSE OF REVIEW: Cannabis and cannabinoids have been used medically and recreationally for thousands of years and recently there has been a growing body of research in this area. With increased access now that medical marijuana is available in many jurisdictions, patients and providers want to know more about the evidence for benefits and risks of cannabinoid use. This paper provides an overview of the available cannabinoid-based formulations, a summary of the highest quality evidence for the use of cannabinoids for treating spasticity and pain associated with multiple sclerosis (MS), and a discussion of possible dosing regimens based on information from these studies...
June 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29922749/assessment-of-pain-quality-reveals-distinct-differences-between-nociceptive-innervation-of-low-back-fascia-and-muscle-in-humans
#14
Andreas Schilder, Walter Magerl, Thomas Klein, Rolf-Detlef Treede
Introduction/Objectives: Verbal descriptors are an important pain assessment parameter. The purpose of this study was to explore the ability to discriminate deep muscle pain and overlying fascia pain according to verbal descriptors and compare the pattern with skin stimulation (from previously published data). Methods: In 16 healthy human subjects, electrical stimulation was chosen to excite a broad spectrum of nociceptive primary afferents innervating the respective tissues...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29921999/neuropathic-pain-current-definition-and-review-of-drug-treatment
#15
REVIEW
Bridin P Murnion
No abstract text is available yet for this article.
June 2018: Australian Prescriber
https://www.readbyqxmd.com/read/29921501/tapentadol-a-representative-of-a-new-class-of-mor-nri-analgesics
#16
REVIEW
Renata Zajączkowska, Barbara Przewłocka, Magdalena Kocot-Kępska, Joanna Mika, Wojciech Leppert, Jerzy Wordliczek
Tapentadol is a centrally acting analgesic with a dual mode of action as a μ-opioid receptor (MOR) agonist and a noradrenaline reuptake inhibitor (NRI). It was initially approved by the US Food and Drug Administration in November 2008 for the treatment of moderate-to-severe acute pain in adult patients, and in August 2011, for chronic pain in an prolonged release form in the same population. Due to its limited protein binding capacity, the absence of active metabolites and significant microsomal enzyme induction or inhibition, tapentadol has a limited potential for drug-drug interactions...
January 31, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29921170/-express-atf2-but-not-atf3-participates-in-the-maintenance-of-nerve-injury-induced-tactile-allodynia-and-thermal-hyperalgesia
#17
Ana Belen Salinas-Abarca, Isabel Velazquez-Lagunas, Urzula Franco-Enzastiga, Jorge Elias Torres-López, Hector Isaac Rocha-Gonzalez, Vinicio Granados-Soto
Transcription factors are proteins that modulate the transcriptional rate of target genes in the nucleus in response to extracellular or cytoplasmic signals. Activating transcription factors 2 (ATF2) and 3 (ATF3) respond to environmental signals and maintain cellular homeostasis. There is evidence that inflammation and nerve injury modulate ATF2 and ATF3 expression. However, the function of these transcription factors in pain is unknown. The purpose of this study was to investigate the contribution of ATF2 and ATF3 to nerve injury-induced neuropathic pain...
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29921169/-express-auricular-vagus-nerve-stimulation-enhances-central-serotonergic-function-and-inhibits-diabetic-neuropathy-development-in-zucker-fatty-rats
#18
Shayuan Li, Chunli Sun, Peijing Rong, Xu Zhai, Jinling Zhang, Max Baker, Shuxing Wang
Painful neuropathy is a frequent comorbidity in diabetes. Zucker diabetic fatty (ZDF, fa/fa) rats develop type 2 diabetes spontaneously with ageing and show nociceptive hypersensitivity by age of 13wk. In preclinical and clinical studies, the treatment of diabetic neuropathy is challenging but complementary medicine like transcutaneous auricular vagus nerve stimulation (taVNS) appears beneficial to the relief of neuropathic pain. However, the mechanism behind the effectiveness of taVNS remains unclear. In this study we show that daily 30min taVNS (2/15Hz, 2mA) for consecutive 27 days effectively inhibited the development of nociceptive hypersensitivity in ZDF rats as detected by thermal hyperalgesia and mechanical allodynia in hindpaw...
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29913995/diagnostic-blocks-for-chronic-pain
#19
Michele Curatolo, Nikolai Bogduk
Many conditions associated with chronic pain have no detectable morphological correlate. Consequently, the source of pain cannot be established by clinical examination or medical imaging. However, for some such conditions, the source of pain can be established using diagnostic blocks. The aim of this paper is to review the available evidence concerning the validity and utility of diagnostic blocks, and to identify areas where research is needed. Diagnostic blocks for cervical and lumbar zygapophysial joint pain have been extensively studied...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913989/difficult-diagnosis-of-facial-pain-a-case-report-and-mini-review
#20
Satu K Jääskeläinen, Heli Forssell, Olli Tenovuo, Riitta Parkkola
This case report elucidates pitfalls of clinical and radiologic investigations of neuropathic pain due to trigeminal pathology, and utility of neurophysiologic examination when diagnosing facial pain. Our patient was a 63-year-old woman who developed acute, severe facial pain, first located behind the left eye. Neuralgic exacerbations, paresthesia within lower face on the left and restricted mouth opening occurred during the course of the disease with gradual progression. Brain MRI and CT scans were interpreted as normal at 4 and 10 months after symptom onset...
December 29, 2017: Scandinavian Journal of Pain
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