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https://www.readbyqxmd.com/read/29042375/non-invasive-brain-stimulation-interventions-for-management-of-chronic-central-neuropathic-pain-a-scoping-review-protocol
#1
Mei Lin Chen, Lin Yao, Jennifer Boger, Kathryn Mercer, Benjamin Thompson, Ning Jiang
INTRODUCTION: Pain can affect people regardless of age, gender or ethnicity. Chronic central neuropathic pain (CCNP) is a debilitating condition that affects populations such as stroke survivors, amputees, spinal cord injury patients and patients with multiple sclerosis, with prevalence rates between 30% and 80%. This condition can be caused by a lesion or disease affecting the somatosensory system. CCNP is notoriously drug resistant, and few effective CCNP treatment or management strategies exist...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29042249/prevalence-and-biochemical-risk-factors-of-diabetic-peripheral-neuropathy-with-or-without-neuropathic-pain-in-taiwanese-adults-with-type-2-diabetes-mellitus
#2
Yen-Wei Pai, Ching-Heng Lin, I-Te Lee, Ming-Hong Chang
AIMS: To investigate the prevalence and risk factors for diabetic peripheral neuropathy with or without neuropathic pain in Taiwanese. METHODS: A cross-sectional, hospital-based observational study was conducted. We enrolled 2837 adults with type 2 diabetes mellitus. Diabetic peripheral neuropathy with or without pain were diagnosed using 2 validated screening tools, namely the Michigan Neuropathy Screening Instrument and Douleur Neuropathique 4 questionnaire. RESULTS: In our sample, 2233 participants had no neuropathy, 476 had diabetic peripheral neuropathy without pain, and 128 had diabetic peripheral neuropathy with neuropathic pain, representing an overall diabetic peripheral neuropathy prevalence of 21...
September 28, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29042208/antiallodynic-activity-of-leflunomide-is-partially-inhibited-by-naltrexone-and-glibenclamide-and-associated-with-reduced-production-of-tnf-%C3%AE-and-cxcl-1
#3
Ana Mercy S Brito, Adriana M Godin, Paulo Sérgio A Augusto, Raquel R Menezes, Ivo S F Melo, Marcela G M B Dutra, Sarah O A M Costa, Franciele A Goulart, Felipe F Rodrigues, Isis MoraisMarcela Ísis Morais, Renes R Machado, Márcio M Coelho
Leflunomide, an immunosuppressive drug approved for the treatment of patients with rheumatoid arthritis, exhibits many mechanisms which may affect the nociceptive processing. Therefore, the present study aimed to evaluate the effect induced by leflunomide on the mechanical allodynia in models of inflammatory and neuropathic pain in mice and investigate mechanisms mediating such effects. Per os (p.o.) administration of leflunomide (25, 50 or 100 mg/kg) inhibited the inflammatory edema and mechanical allodynia induced by intraplantar carrageenan...
October 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29039325/comparative-role-of-pregabalin-and-carbamazepine-regarding-efficacy-in-painful-diabetic-neuropathy
#4
Raana Mahmood, Itrat Jawed, M Irfan Khan, Iffat Mahmood, Talat Tariq, Arfa Kamil, Faiza Z Sayeed, Bushra Z Sayeed
Neuropathic pain is the most severe and resistant type of pain which has impact on quality of life and behaviour; it most commonly occurs at night causing disturbed sleep. Diabetes mellitus is a common cause of painful neuropathy. In this study, we are comparing the effectiveness of old treatment Carbamazepine with Pregabalin in painful diabetic neuropathy. The study was an open-label trial conducted in Diabetic Clinic of Medical Unit-III, Jinnah Post-graduate Medical Center, Karachi. The duration of the study was 90 days, from December 2010 to March 2011...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29039152/evaluation-of-the-neuropathic-pain-in-the-smokers
#5
Sercan Bulut Çelik, Hüseyin Can, Melih Kaan Sözmen, Tijen Şengezer, Yusuf Cem Kaplan, Gökçenur Utlu, Alp Şener, Arzu Aybek Yılmaz, Olgu Aygün
OBJECTIVES: Nicotine addiction is one of the most important causes of the general failure of treatment and keeping the habit of smoking. Peripheral neuropathy is a leading factor of smoking. This study aimed to analyze the association of neuropathic pain and addiction levels of individuals. METHODS: The study was performed on the day on which the smokers visited the hospital for any reason. The Douleur Neuropathique 4 (DN-4) Scale and Fagerström Addiction Survey were administered to the individuals after obtaining their consent...
July 2017: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/29037608/chemokine-ccl8-and-its-receptor-ccr5-in-the-spinal-cord-are-involved-in-visceral-pain-induced-by-experimental-colitis-in-mice
#6
Ying Lu, Bao-Chun Jiang, De-Li Cao, Lin-Xia Zhao, You-Li Zhang
Visceral hypersensitivity induced by inflammatory bowel disease (IBD) is a clinical challenge since the underlying mechanisms remain elusive. Chemokines and their receptors have been suggested to modulate inflammatory pain and neuropathic pain. However, the exact chemokines involved in visceral pain remain to be determined. Here, we investigated the effects of spinal chemokine CCL8 and its major receptor CCR5 on the development of visceral hyperalgesia. We showed that intracolonic injection of 2,4,6-trinitrobenzene sulfonic acid (TNBS) in mice produced significant colonic inflammation and visceral hypersensitivity to colorectal distension...
October 13, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29036889/single-administration-of-melatonin-modulates-the-nitroxidergic-system-at-the-peripheral-level-and-reduces-thermal-nociceptive-hypersensitivity-in-neuropathic-rats
#7
Elisa Borsani, Barbara Buffoli, Veronica Bonazza, Russel J Reiter, Rita Rezzani, Luigi F Rodella
Neuropathic pain is a severe condition with unsatisfactory treatments. Melatonin, an indolamine, seems to be a promising molecule suitable for this purpose due to its well-known anti-inflammatory, analgesic, and antioxidant effects, as well as its modulation of the nitroxidergic system. Nevertheless, the data on its mechanism of action and potentialities are currently insufficient in this pathology, especially at the peripheral level. Thus, this work evaluated the effect of a single administration of melatonin in an established mononeuropathy pain model that monitors the behaviour and the changes in the nitroxidergic system in dorsal root ganglia and skin, which are affected by nervous impairment...
October 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29034548/electroacupuncture-alleviates-chemotherapy-induced-pain-through-inhibiting-phosphorylation-of-spinal-camkii-in-rats
#8
Y Zhang, A Li, J Xin, K Ren, B M Berman, L Lao, R-X Zhang
BACKGROUND: Current medical treatments for chemotherapy-induced pain (CIP) are either ineffective or have adverse side effects. Acupuncture may alleviate CIP, but its effectiveness against this condition has not been studied. Paclitaxel causes neuropathic pain in cancer patients. METHODS: We evaluated the effects of electroacupuncture (EA) on paclitaxel-induced CIP in a rat model. Paclitaxel (2 mg/kg) or vehicle was injected (i.p.) on alternate days of 0-6. The resulting pain was treated with 10 Hz/2 mA/0...
October 16, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29034533/efficacy-tolerability-and-safety-of-cannabis-based-medicines-for-chronic-pain-management-an-overview-of-systematic-reviews
#9
REVIEW
W Häuser, F Petzke, M-A Fitzcharles
Medicinal cannabis has already entered mainstream medicine in some countries. This systematic review (SR) aimed at evaluating the efficacy, acceptability and safety of cannabis-based medicines for chronic pain management. Qualitative systematic review of SRs of randomized controlled trials with cannabis-based medicines for chronic pain management. The Cochrane databases of SRs, Database of Abstracts of Reviews of Effects and PubMed were searched for SR published in the period January 2009 to January 2017. Assessment of the methodological quality of SR was performed by the AMSTAR checklist...
October 15, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29032001/efficacy-of-self-retained-cryopreserved-amniotic-membrane-for-treatment-of-neuropathic-corneal-pain
#10
Melina I Morkin, Pedram Hamrah
PURPOSE: Treatment of neuropathic corneal pain (NCP) remains intricate, and involves a long-term combined multistep approach. The self-retained cryopreserved amniotic membrane (PROKERA(®), Bio-Tissue, Miami,FL) has been utilized for multiple ocular surface disorders. We evaluate the efficacy, safety, and tolerability of ProKera(®) Slim [PKS] and ProKera(®) Clear [PKC] in the treatment of NCP. METHODS: Retrospective case series of 9 patients who received PKS/PKC for the acute treatment of NCP...
October 12, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29031913/chronic-pain-and-pain-processing-in-parkinson-s-disease
#11
REVIEW
Pierre J Blanchet, Christine Brefel-Courbon
Pain is experienced by the vast majority of patients living with Parkinson's disease. It is most often of nociceptive origin, but may also be ascribed to neuropathic (radicular or central) or miscellaneous sources. The recently validated King's Parkinson's Disease Pain Scale is based on 7 domains including musculoskeletal pain, chronic body pain (central or visceral), fluctuation-related pain, nocturnal pain, oro-facial pain, pain with discolouration/oedema/swelling, and radicular pain. The basal ganglia integrate incoming nociceptive information and contribute to coordinated motor responses in pain avoidance and nocifensive behaviors...
October 12, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29031858/involvement-of-integrin-%C3%AE-1-fak-signaling-in-the-analgesic-effects-induced-by-glial-cell-line-derived-neurotrophic-factor-in-neuropathic-pain
#12
Hong-Jun Wang, Ge Song, Jian Liang, Yuan-Yuan Gao, Cun-Jin Wang
Treatment of neuropathic pain (NP) continues to be a clinical challenge and the underlying mechanisms of NP remain elusive. More evidence suggests that glial cell line-derived neurotrophic factor (GDNF) has potent anti-nociceptive effects on NP, but the underlying mechanisms are still largely unknown. Recent data have shown that integrin β1 plays an important part in NP induction, and that the activity of integrin β1 signaling is associated with the phosphorylation of the conserved threonines in the cytoplasmic domain and recruitment of focal adhesion kinase (FAK) to the integrin β1 tail and phosphorylation...
October 12, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29031645/neuropathic-pain-and-dry-eye
#13
REVIEW
Anat Galor, Hamid-Reza Moein, Charity Lee, Adriana Rodriguez, Elizabeth R Felix, Konstantinos D Sarantopoulos, Roy C Levitt
Dry eye is a common, multifactorial disease currently diagnosed by a combination of symptoms and signs. Its epidemiology and clinical presentation have many similarities with neuropathic pain outside the eye. This review highlights the similarities between dry eye and neuropathic pain, focusing on clinical features, somatosensory function, and underlying pathophysiology. Implications of these similarities on the diagnosis and treatment of dry eye are discussed.
October 11, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29030971/nicotinic-acetylcholine-receptors-in-neuropathic-and-inflammatory-pain
#14
REVIEW
Arik J Hone, J Michael McIntosh
Nicotinic acetylcholine receptors (nAChRs) are actively being investigated as therapeutic targets for the treatment of pain and inflammation, but despite more than 30 years of research, there are currently no FDA approved analgesics that target these receptors. Much of the initial research effort focused on the α4β2 subtype, but more recently, additional subtypes have been identified as promising new therapeutic targets and include α6β4, α7 and α9-containing subtypes. This Review will focus on the distribution of these nAChRs in the cell types involved in neuropathic pain and inflammation as well as current pharmacological compounds that target them...
October 14, 2017: FEBS Letters
https://www.readbyqxmd.com/read/29030173/a-novel-miniature-wireless-neurostimulator-in-the-management-of-chronic-craniofacial-pain-preliminary-results-from-a-prospective-pilot-study
#15
Richard L Weiner, Carlos Montes Garcia, Niek Vanquathem
OBJECTIVE: To report a novel wireless neuromodulation system for treatment of refractory craniofacial pain. BACKGROUND: Previous studies utilizing peripheral nerve stimulation (PNS) of the occipital and trigeminal nerves reported positive outcomes for alleviating neuropathic pain localized to the craniofacial and occipital areas. However several technological limitations and cosmetic concerns inhibited a more widespread acceptance and use of neuromodulation. Also, a relatively high incidence of adverse events like electrode erosions, dislocation, wire fracture and/or infection at the surgical site mandates a change in our approach to neuromodulation technology and implant techniques in the craniofacial region...
October 10, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29028074/efficacy-and-safety-of-5-lidocaine-medicated-plasters-in-localized-pain-with-neuropathic-and-or-inflammatory-characteristics-an-observational-real-world-study
#16
F Amato, G Duse, L Consoletti, C Lo Presti, V Firetto, G Ciliberto, L A Parigi, V Palmieri, M Mazza
OBJECTIVE: Based on clinical study results, 5% lidocaine-medicated plaster (5% LMP) is currently recommended for the treatment of localized peripheral neuropathic pain, such as post-herpetic neuralgia (PHN). However, its effective action, as well as the high safety, have indeed led to its use in clinical practice for pain conditions with similar pathophysiological mechanisms. In this study, the efficacy and safety of 5% LMP were investigated in patients with localized pain with neuropathic and/or inflammatory characteristics, such as PHN, post-traumatic/surgical or musculoskeletal pain...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29026967/a-rat-model-of-folfox-induced-neuropathy-effects-of-oral-dimiracetam-in-comparison-with-duloxetine-and-pregabalin
#17
Lorenzo Di Cesare Mannelli, Mario Maresca, Laura Micheli, Carlo Farina, Michael W Scherz, Carla Ghelardini
BACKGROUND AND AIM: The FOLFOX family of chemotherapy regimens are hampered by the development of a painful neuropathy. Current clinical treatments are inadequate, and furthermore, the research of innovative drugs is strongly disadvantaged by the absence of a preclinical model based on the complete mixture of FOLFOX components. The aim of this study was to set up a rat model of FOLFOX-induced neuropathy in rats, validate its predictability by reference drugs, and evaluate the effectiveness of the new anti-neuropathic compound dimiracetam...
October 12, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29025327/post-herpetic-neuralgia-a-review-of-current-management-and-future-directions
#18
John Schutzer-Weissmann, Paul Farquhar-Smith
Post-herpetic neuralgia (PHN) is common and treatment is often suboptimal with less than half of patients achieving adequate 50% pain relief. As an area of unmet clinical need and as an archetype of neuropathic pain, it deserves the attention of clinicians and researchers. Areas covered: This review summarises the epidemiology, pathophysiology, risk factors and clinical features of varicella infection. It describes the current and possible future management strategies for preventing varicella infection and reactivation and for treating PHN...
October 13, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29025136/predictors-of-responsivity-to-interdisciplinary-pain-management
#19
Melissa A Day, Melissa Brinums, Nathan Craig, Laurence Geffen, Saul Geffen, Miriam Lovai, Gina Geffen
Objective: This study investigated for whom interdisciplinary pain management (IPM) is most effective. Identification of predictors of treatment responsivity would facilitate development of patient-treatment matching algorithms to optimize outcomes. Design: Repeated measures prospective study of consecutive admissions to a two-week IPM program. Setting: Brisbane Pain Rehabilitation Service in Brisbane, Australia. Subjects: A total of 163 adults referred for chronic pain management...
July 25, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29025132/most-relevant-neuropathic-pain-treatment-and-chronic-low-back-pain-management-guidelines-a-change-pain-latin-america-advisory-panel-consensus
#20
Cesar Amescua-Garcia, Frantz Colimon, Carlos Guerrero, Aziza Jreige Iskandar, Maria Berenguel Cook, Patricia Bonilla, Durval Campos Kraychete, William Delgado Barrera, Jose Alberto Flores Cantisani, John Jairo Hernandez-Castro, Argelia Lara-Solares, Concepcion Perez Hernandez, Maria Antonieta Rico, Maria Del Rocio Guillen Nunez, Manuel Sempertegui Gallegos, Joao Batista Santos Garcia
Objective: Chronic pain conditions profoundly affect the daily living of a significant number of people and are a major economic and social burden, particularly in developing countries. The Change Pain Latin America (CPLA) advisory panel aimed to identify the most appropriate guidelines for the treatment of neuropathic pain (NP) and chronic low back pain (CLBP) for use across Latin America. Methods: Published systematic reviews or practice guidelines were identified by a systematic search of PubMed, the Guidelines Clearinghouse, and Google...
August 24, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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