keyword
MENU ▼
Read by QxMD icon Read
search

Nociceptive pain

keyword
https://www.readbyqxmd.com/read/29923259/chronic-pain-in-narcolepsy-type-1-and-type-2-an-underestimated-reality
#1
Renata C Cremaschi, Camila Hirotsu, Sergio Tufik, Fernando M Coelho
Narcolepsy is a rare sleep disorder classified in types 1 and 2. The co-morbidities of narcolepsy type 1, with hypocretin-1 deficiency, are established. Hypocretin-1 in the central and peripheral nervous systems regulates nociception and pain. However, the patients with narcolepsy type 2 have similar excessive daytime sleepiness and co-morbidities without elucidation. The objective of the study was to determine the frequency and the characteristic of chronic pain according to the type of narcolepsy. We also investigated the effect of the interaction between the nutritional status and the type of narcolepsy...
June 19, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29922999/effect-of-fluoxetine-in-prenatal-period-on-nociceptive-system-reactivity-and-psychoemotional-behavior-in-young-female-rats
#2
I P Butkevich, V A Mikhailenko
We studied the effect of chronic injections of serotonin reuptake inhibitor fluoxetine to rats during pregnancy on physiological and behavioral characteristics of female offspring during the prepubertal period. Fluoxetine reduced body weight in newborn females, but this parameter was restored to normal values by the age of 25 days. Fluoxetine also increased animal anxiety, but did not change the level of depressive behavior and cognitive capacities. It was shown that chronic injections of physiological solution to pregnant female enhanced nociceptive responses in the offspring during the prepubertal period, while fluoxetine neutralized the consequences of invasive intervention, which was expressed in a lower level of pain reaction in the offspring...
June 19, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29922749/assessment-of-pain-quality-reveals-distinct-differences-between-nociceptive-innervation-of-low-back-fascia-and-muscle-in-humans
#3
Andreas Schilder, Walter Magerl, Thomas Klein, Rolf-Detlef Treede
Introduction/Objectives: Verbal descriptors are an important pain assessment parameter. The purpose of this study was to explore the ability to discriminate deep muscle pain and overlying fascia pain according to verbal descriptors and compare the pattern with skin stimulation (from previously published data). Methods: In 16 healthy human subjects, electrical stimulation was chosen to excite a broad spectrum of nociceptive primary afferents innervating the respective tissues...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29922748/inflammatory-induced-spinal-dorsal-horn-neurons-hyperexcitability-is-mediated-by-p2x4-receptors
#4
Franck Aby, Sara Whitestone, Marc Landry, Lauriane Ulmann, Pascal Fossat
Introduction: Purinergic ionotropic P2X receptors (P2RX) are involved in normal and pathological pain transmission. Among them, P2X4 are expressed in dorsal root ganglion and in the spinal cord. Their activation during nerve injury or chronic peripheral inflammation modifies pain sensitivity that leads to the phenomenon of allodynia and hyperalgesia. Objectives: We study here, in vivo, the role of P2X4 on the excitability of dorsal horn neurons (DHNs) in naive or pathological context...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29922747/serum-response-factor-mediates-nociceptor-inflammatory-pain-plasticity
#5
Ruben Gomez, Dorothy M Kohler, Allison D Brackley, Michael A Henry, Nathaniel A Jeske
Introduction: Chronic metabotropic glutamate receptor activation in nociceptive afferents may upregulate A-Kinase Anchoring Protein 150 (AKAP150) expression and/or function. Objectives: To quantify transcriptional changes in AKAP150 expression and/or function after long-term mGluR5 agonist exposure, and identify transcriptional elements responsible. Methods: Dorsal root ganglia (DRG) were dissected from Sprague-Dawley rats and cultured for biochemical analysis of AKAP150 expression after prolonged mGluR5 agonist exposure...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29922746/reduced-intraepidermal-nerve-fibre-density-glial-activation-and-sensory-changes-in-hiv-type-1-tat-expressing-female-mice-involvement-of-tat-during-early-stages-of-hiv-associated-painful-sensory-neuropathy
#6
Rachel Wodarski, Deniz Bagdas, Jason J Paris, Tim Pheby, Wisam Toma, Ruqiang Xu, M Imad Damaj, Pamela E Knapp, Andrew S C Rice, Kurt F Hauser
Introduction: HIV infection is associated with chronic pain states, including sensory neuropathy, which affects greater than 40% of patients. Objectives and Methods: To determine the impact of HIV-Tat induction on nociceptive behaviour in female mice conditionally expressing HIV Tat1-86 protein through a doxycycline (DOX)-driven glial fibrillary acidic protein promoter, intraepidermal nerve fibre density and immune cell activation in the dorsal root ganglion (DRG) and spinal cord were assessed by immunohistochemistry...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29921501/tapentadol-a-representative-of-a-new-class-of-mor-nri-analgesics
#7
REVIEW
Renata Zajączkowska, Barbara Przewłocka, Magdalena Kocot-Kępska, Joanna Mika, Wojciech Leppert, Jerzy Wordliczek
Tapentadol is a centrally acting analgesic with a dual mode of action as a μ-opioid receptor (MOR) agonist and a noradrenaline reuptake inhibitor (NRI). It was initially approved by the US Food and Drug Administration in November 2008 for the treatment of moderate-to-severe acute pain in adult patients, and in August 2011, for chronic pain in an prolonged release form in the same population. Due to its limited protein binding capacity, the absence of active metabolites and significant microsomal enzyme induction or inhibition, tapentadol has a limited potential for drug-drug interactions...
January 31, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29921170/-express-atf2-but-not-atf3-participates-in-the-maintenance-of-nerve-injury-induced-tactile-allodynia-and-thermal-hyperalgesia
#8
Ana Belen Salinas-Abarca, Isabel Velazquez-Lagunas, Urzula Franco-Enzastiga, Jorge Elias Torres-López, Hector Isaac Rocha-Gonzalez, Vinicio Granados-Soto
Transcription factors are proteins that modulate the transcriptional rate of target genes in the nucleus in response to extracellular or cytoplasmic signals. Activating transcription factors 2 (ATF2) and 3 (ATF3) respond to environmental signals and maintain cellular homeostasis. There is evidence that inflammation and nerve injury modulate ATF2 and ATF3 expression. However, the function of these transcription factors in pain is unknown. The purpose of this study was to investigate the contribution of ATF2 and ATF3 to nerve injury-induced neuropathic pain...
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29921169/-express-auricular-vagus-nerve-stimulation-enhances-central-serotonergic-function-and-inhibits-diabetic-neuropathy-development-in-zucker-fatty-rats
#9
Shayuan Li, Chunli Sun, Peijing Rong, Xu Zhai, Jinling Zhang, Max Baker, Shuxing Wang
Painful neuropathy is a frequent comorbidity in diabetes. Zucker diabetic fatty (ZDF, fa/fa) rats develop type 2 diabetes spontaneously with ageing and show nociceptive hypersensitivity by age of 13wk. In preclinical and clinical studies, the treatment of diabetic neuropathy is challenging but complementary medicine like transcutaneous auricular vagus nerve stimulation (taVNS) appears beneficial to the relief of neuropathic pain. However, the mechanism behind the effectiveness of taVNS remains unclear. In this study we show that daily 30min taVNS (2/15Hz, 2mA) for consecutive 27 days effectively inhibited the development of nociceptive hypersensitivity in ZDF rats as detected by thermal hyperalgesia and mechanical allodynia in hindpaw...
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29920331/preoperative-neuropathic-pain-like-symptoms-and-central-pain-mechanisms-in-knee-osteoarthritis-predicts-poor-outcome-6-months-after-total-knee-replacement-surgery
#10
Thomas Kurien, Lars Arendt-Nielsen, Kristian K Petersen, Thomas Graven-Nielsen, Brigitte E Scammell
Preoperative pain characteristics in osteoarthritis (OA) patients may explain persistent pain after total knee replacement (TKR). Fifty patients awaiting TKR and 22 asymptomatic controls were recruited to evaluate the degree of neuropathic pain symptoms and pain sensitisation. OA patients were pain phenotyped into two groups based on the PainDETECT questionnaire: High PainDETECT group (scores ≥19) indicating neuropathic pain-like symptoms, Low PainDETECT group (scores <19) indicating nociceptive or mixed pain...
June 16, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29917237/the-extracellular-matrix-glycoprotein-tenascin-x-regulates-peripheral-sensory-and-motor-neurones
#11
Rubina Aktar, Madusha Peiris, Asma Fikree, Vincent Cibert-Goton, Maxim Walmsley, Iain R Tough, Paulo Watanabe, Eduardo J A Araujo, Sahar D Mohammed, Jean-Marie Delalande, David C Bulmer, S Mark Scott, Helen M Cox, Nicol C Voermans, Qasim Aziz, L Ashley Blackshaw
The extracellular matrix (ECM) is not only an integral structural molecule, but is also critical for a wide range of cellular functions. The glycoprotein tenascin-X (TNX) predominates in the ECM of tissues like skin and regulates tissue structure through anti-adhesive interactions with collagen. Monogenic TNX deficiency causes painful joint hypermobility and skin hyperelasticity, symptoms characteristic of hypermobility-Ehlers Danlos Syndrome (hEDS). hEDS patients also report consistently increased visceral pain and gastrointestinal (GI) dysfunction...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29917139/structural-brain-alterations-before-and-after-total-knee-arthroplasty-a-longitudinal-assessment
#12
Gwyn N Lewis, Rosalind S Parker, Sheena Sharma, David A Rice, Peter J McNair
Objective: Many studies have provided evidence of altered brain structure in chronic pain conditions, as well as further adaptations following treatment that are coincident with changes in pain. Less is known regarding how these structural brain adaptations relate to assessments of nociceptive processing. The current study aimed to investigate brain structure in people with knee osteoarthritis (OA) before and after total knee arthroplasty (TKA) and to investigate the relationships between these findings and quantitative sensory testing (QST) of the nociceptive system...
June 15, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29916863/parasympathetic-tone-activity-evaluation-to-discriminate-ketorolac-and-ketorolac-tramadol-analgesia-level-in-swine
#13
Carlos J Leitão, Juan Rafael Lima-Rodríguez, Fatima Ferreira, Catarina Avelino, Francisco M Sánchez-Margallo, Luís Antunes
BACKGROUND: Evaluation of nociceptive-antinociceptive balance during general anesthesia is still challenging and routinely based on clinical criteria. Analgesic drug delivered may be optimized with parasympathetic tone activity (PTA) monitor. This study compares ketorolac and ketorolac/tramadol balance analgesia using a PTA monitor. METHODS: Pain intensity response was assessed using a 0-100 numerical state scale (PTA) after nociceptive stimuli in pigs under stable sevoflurane anesthesia...
June 14, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29915504/effects-of-intratesticular-injection-of-zinc-based-solution-in-rats-in-combination-with-anti-inflammatory-and-analgesic-drugs-during-chemical-sterilization
#14
Simone Regina Barros de Macêdo, Luiz André Rodrigues de Lima, Sandra Maria de Torres, Vinícius Vasconcelos Gomes de Oliveira, Rosana Nogueira de Morais, Christina Alves Peixoto, Bruno Mendes Tenorio, Valdemiro Amaro da Silva Junior
Aim: Chemical sterilization is a non-surgical method of contraception based on compounds injected into the testis to induce infertility. However, these injections can cause discomfort and pain able to impair the recovery of animals after this treatment. The objective of this study was to investigate if anti-inflammatories or pain relievers inhibited the sterilizing effect of zinc gluconate-based solution on the testis. Materials and Methods: Adult rats were treated in groups: G1 (control), G2 (dimethyl sulfoxide + dipyrone); G3 (dipyrone/zinc); G4 (dipyrone + celecoxib/zinc); G5 (dipyrone + meloxicam/zinc), and G6 (dipyrone + dexamethasone/zinc) in a single dose per day during 7 days...
May 2018: Veterinary World
https://www.readbyqxmd.com/read/29913974/pigs-in-pain-porcine-behavioural-responses-towards-mechanical-nociceptive-stimulation-directed-at-the-hind-legs
#15
Mette S Herskin, Julie S Rasmussen
Objectives In recent years, pigs are used increasingly for biomedical translational research and often considered superior to rodent models. However, only very few pain assays for quantification of behavioural nociceptive responses are available for pigs. This experiment is part of a larger project aiming at developing pain assays for pigs, and the present aim was to examine behavioural responses towards mechanical cutaneous stimulation applied to the caudal part of the metatarsus on the hind legs of pigs using an IITC Electronic von Frey Anesthesiometer...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913971/brain-activation-due-to-postoperative-pain-from-the-right-hand-measured-with-regional-cerebral-blood-flow-using-positron-emission-tomography
#16
Torsten Gordh, Bertil Vinnars, Håkan Fischer, Hans Blomberg, Jan Modig, Mats Fredrikson, Per Hartvig
Background Brain activation resulting from acute postoperative pain has to our knowledge not previously been studied using positron emission tomography, except from one case study. The aim of this study was to monitor activation in brain sensory pathways during acute pain after surgery of the hand. A secondary aim was to compare brain activation in clinical postoperative pain to that previously reported, by the same research group, for a model of experimental pain from the same body area. Increase in regional cerebral blood flow (rCBF) is presumed to indicate neuronal activation and decrease in blood flow decreased neuronal firing...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913949/long-term-pain-neuroinflammation-and-glial-activation
#17
Elisabeth Hansson
Nociceptive and neuropathic pain signals are known to result from noxious stimuli, which are converted into electrical impulses within tissue nociceptors. There is a complex equilibrium of pain-signalling and pain-relieving pathways connecting PNS and CNS. Drugs against long-term pain are today directed against increased neuronal excitability, mostly with less success. An injury often starts with acute physiological pain, which becomes inflammatory, nociceptive, or neuropathic, and may be transferred into long-term pain...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913917/the-mineralocorticoid-receptor-antagonist-spironolactone-enhances-morphine-antinociception
#18
Viljami Jokinen, Tuomas O Lilius, Mikko S Neuvonen, Antti J Väänänen, Mikko O Niemi, Pekka V Rauhala, Eija A Kalso
Aims Spironolactone, an antimineralocorticoid, has been reported to potentiate the cataleptic effect of morphine in the rat. Since no previous research exists on the matter and the interaction might be clinically significant, the effects of spironolactone on morphine antinociception and pharmacokinetics in the rat were investigated. Methods Male SD rats were used to assess the effects of spironolactone on acute morphine-induced antinociception, development of morphine tolerance, and established morphine tolerance in the tail-flick and hot plate tests...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913901/painful-heat-attenuates-electrically-induced-muscle-pain-in-men-and-women
#19
Maria Gullander, Stein Knardahl, Dagfinn Matre
Aabstract Background and purpose Women exhibit higher prevalence of most painful disorders. Several explanations have been proposed for this discrepancy, one being that endogenous pain modulatory pathways, which affect incoming nociceptive signals, act differently in men and women. A less efficient pain inhibitory system has been proposed as a contributing factor to explain why women exhibit higher prevalence of most painful disorders. The present study determined whether muscle pain, induced experimentally by electrical stimulation, is inhibited by a painful heat stimulus...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913899/percentile-normative-values-of-parameters-of-electrical-pain-and-reflex-thresholds
#20
Pasquale Scaramozzino, Alban Y Neziri, Ole K Andersen, Lars Arendt-Nielsen, Michele Curatolo
Aabstract Background and purpose Central hypersensitivity, defined as an increased excitability of the central nervous system, is considered as the main factor behind facilitation of central pain processes and is probably a very important factor in the induction and maintenance of chronic pain. Widespread hyposensitivity is less studied than hypersensitivity states, but recent work indicates that hypoesthesia may be present in chronic non-neuropathic pain conditions and could have negative prognostic value...
December 29, 2017: Scandinavian Journal of Pain
keyword
keyword
43015
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"