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https://www.readbyqxmd.com/read/28929961/-national-antimicrobial-resistance-surveillance-system-namrss-external-quality-assessment-studies-2011-2016
#1
Serap Süzük Yıldız, Hüsniye Şimşek, Nilay Çöplü, Zeynep Gülay
Establishment of sustainable and evidence-based surveillance systems are recommended for prevention of microbial resistance by the World Health Organization (WHO). As a necessity of these surveillance systems, participants are recommended to implement an external quality assessment (EQA) program. In this scope, National Antimicrobial Resistance Surveillance System (NARSS) has been established within the Public Health Institute of Turkey (PHIT) in our country since 2011. In the scope of this surveillance, NARSS EQA program has been implemented in a cycle per year and four isolates were sent to participants per cycle every year since 2011...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28929313/an-anti-propionibacterium-acnes-antibody-shows-heterologous-resistance-to-an-actinobacillus-pleuropneumoniae-infection-independent-of-neutrophils-in-mice
#2
Jian-Fang Liu, Qiu-Yue Ma, Ri-Ning Zhu, Meng-Jun Cheng, Chun-Tong Bao, Jing-Min Gu, Chang-Jiang Sun, Paul Richard Langford, Wen-Yu Han, Lian-Cheng Lei
Porcine contagious pleuropneumonia is a highly fatal respiratory disease that is caused by Actinobacillus pleuropneumoniae (APP) and results in tremendous economic losses for the pig breeding industry worldwide. Previous studies have demonstrated that Propionibacterium acnes (PA) could effectively prevent APP infection in mice and pigs. The humoral immune response played a primary role during this process and anti-PA antibody could mediate macrophages to kill the bacteria. However, the role of neutrophils in this process is currently unknown...
September 20, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28928474/using-experimental-evolution-to-identify-druggable-targets-that-could-inhibit-the-evolution-of-antimicrobial-resistance
#3
Heer H Mehta, Amy G Prater, Yousif Shamoo
With multi-drug and pan-drug-resistant bacteria becoming increasingly common in hospitals, antibiotic resistance has threatened to return us to a pre-antibiotic era that would completely undermine modern medicine. There is an urgent need to develop new antibiotics and strategies to combat resistance that are substantially different from earlier drug discovery efforts. One such strategy that would complement current and future antibiotics would be a class of co-drugs that target the evolution of resistance and thereby extend the efficacy of specific classes of antibiotics...
September 20, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28924925/in-vitro-activity-of-linezolid-alone-and-combined-with-other-antibiotics-against-clinical-enterococcal-isolates
#4
Mahtab Beitdaghar, Roya Ahmadrajabi, Afsaneh Karmostaji, Fereshteh Saffari
BACKGROUND: The increasing incidence of antimicrobial resistance has led to research on finding new antimicrobial agents or identifying drug combinations with synergistic effects. Enterococcal infections, particularly those associated with vancomycin-resistant enterococci (VREs), are therapeutic problems. Linezolid (LZD), an oxazolidinone antibiotic, shows good activity against Gram-positive bacteria including enterococci. To avoid the emergence of linezolid-resistant subpopulations and achieve enhanced activity or bactericidal effect, the use of combined therapy has been considered...
September 18, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28924229/variations-in-oral-microbiota-associated-with-oral-cancer
#5
Hongsen Zhao, Min Chu, Zhengwei Huang, Xi Yang, Shujun Ran, Bin Hu, Chenping Zhang, Jingping Liang
Individual bacteria and shifts in microbiome composition are associated with human disease, including cancer. To unravel the connections underlying oral bacterial dysbiosis and oral squamous cell carcinoma (OSCC), cancer lesion samples and anatomically matched normal samples were obtained from the same patients. We then profiled the bacteria within OSCC lesion surface samples at the species level using next-generation sequencing to comprehensively investigate bacterial community composition and functional genes in these samples...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923564/multi-step-synthesis-spectroscopic-studies-of-biological-active-steroidal-thiosemicarbazones-and-their-palladium-ii-complex-as-macromolecules
#6
Salman A Khan, Abdullah M Asiri
Steroidal Pd (II) metal complexes were synthesized by the reaction of steroidal thiosemicarbazones with [Pd (DMSO)2 Cl2]. The steroidal thiosemicarbazones coordinate to palladium through the azomethine nitrogen and thionic sulfur. The thiosemicarbazone derivatives were obtained by the reaction of thiosemicarbazide with steroidal ketones. The identity of steroidal thiosemicarbazones and their Pd(II) metal complexes were elucidated by IR, (1)H, (13)C NMR, FAB mass spectroscopic methods, elemental analysis and TGA analysis...
September 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28923075/lipase-and-biosurfactant-from-ochrobactrum-intermedium-strain-mzv101-isolated-by-washing-powder-for-detergent-application
#7
Mina Zarinviarsagh, Gholamhossein Ebrahimipour, Hossein Sadeghi
BACKGROUND: Alkaline thermostable lipase and biosurfactant producing bacteria are very interested at detergent applications, not only because of their eco-friendly characterize, but alsoproduction lipase and biosurfactant by using cheap materials. Ochrobactrum intermedium strain MZV101 was isolated as washing powder resistant, alkaline thermostable lipase and biosurfactant producing bacterium in order to use at detergent applications. METHODS: O. intermedium strain MZV101 produces was lipase and biosurfactant in the same media with pH 10 and temperature of 60 °C...
September 18, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28922632/antibacterial-and-anti-biofouling-coating-on-hydroxyapatite-surface-based-on-peptide-modified-tannic-acid
#8
Xiao Yang, Pei Huang, Haihuan Wang, Shuang Cai, Yixue Liao, Ziqin Mo, Xinyuan Xu, Chunmei Ding, Changsheng Zhao, Jianshu Li
Hydroxyapatite-based implant is widely used in the fields of artificial teeth and bones. However, the problem of microbial communities on hydroxyapatite surfaces remain a great challenge. In order to inhibit bacterial adhesion and activity in a long term, a salivary acquired pellicle (SAP) bioinspired tannic acid (SAP3-TA) is synthesized and characterized. The SAP inspired peptide sequence DDDEEK has a good adsorption performance on the surface of hydroxyapatite (HA). Tannic acid (TA) is a natural polyphenolic compound that can be extracted from green tea, and it has been proved to have an effective antibacterial property...
September 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28922286/nocardia-infections-in-solid-organ-and-hematopoietic-stem-cell-transplant-recipients
#9
Julien Coussement, David Lebeaux, Claire Rouzaud, Olivier Lortholary
PURPOSE OF REVIEW: Nocardia spp. is a gram-positive bacteria that may cause infections in humans. Nocardiosis has been described since the early years of transplantation. This review aims to provide an overview of present knowledge regarding posttransplant nocardiosis, with a focus on recent findings. RECENT FINDINGS: Nocardiosis is not rare among transplant recipients, especially after thoracic transplantation and/or in case of intense immunosuppressive regimen or use of tacrolimus...
September 15, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28920628/fluoroquinolones-as-imaging-agents-for-bacterial-infection
#10
Syed Ali Raza Naqvi, Karl Drlica
Diagnosis of deep-seated bacterial infection is difficult, as neither standard anatomical imaging nor radiolabeled, autologous leukocytes distinguish sterile inflammation from infection. Two recent imaging efforts are receiving attention: (1) radioactive derivatives of sorbitol show good specificity with Gram-negative bacterial infections, and (2) success in combining anatomical and functional imaging for cancer diagnosis has rekindled interest in (99m)Tc-fluoroquinolone-based imaging. With the latter, computed tomography (CT) would be combined with single-photon-emission-computed tomography (SPECT) to detect (99m)Tc-fluoroquinolone-bacterial interactions...
September 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28918351/susceptibility-profiles-of-bacteria-causing-urinary-tract-infection-in-southern-tunisia
#11
Sonda Guermazi-Toumi, Sirine Boujlel, Mouna Assoudi, Riadh Issaoui, Sonia Tlili, Mohamed Ennaceur Hlaiem
OBJECTIVES: The aim of this study was to determine the epidemiological profile and the antibiotic resistance of bacteria responsible for urinary infections diagnosed in the department of microbiology of the regional hospital Houcine Bouzaiene (Gafsa) in the south west of Tunisia. METHODS: All the cytobacteriological urine samples analyzed from 1 January 2015 to 30 June 2016 were included in the study. The adopted criteria to define urinary infection were: leukocyturia >10(4)/ml and bacteriuria >10(5)CFU/ml...
September 13, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28918348/enhancing-protein-to-extremely-high-content-in-photosynthetic-bacteria-during-biogas-slurry-treatment
#12
Anqi Yang, Guangming Zhang, Fan Meng, Pei Lu, Xintian Wang, Meng Peng
This work proposed a novel approach to achieve an extremely high protein content in photosynthetic bacteria (PSB) using biogas slurry as a culturing medium. The results showed the protein content of PSB could be enhanced strongly to 90% in the biogas slurry, which was much higher than reported microbial protein contents. The slurry was partially purified at the same time. Dark-aerobic was more beneficial than light-anaerobic condition for protein accumulation. High salinity and high ammonia of the biogas slurry were the main causes for protein enhancement...
August 20, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28917926/bioadhesive-and-biocompatible-films-as-wound-dressing-materials-based-on-a-novel-dendronized-chitosan-loaded-with-ciprofloxacin
#13
Mónica C García, Ana A Aldana, Luis I Tártara, Fabiana Alovero, Miriam C Strumia, Rubén H Manzo, Marisa Martinelli, Alvaro F Jimenez-Kairuz
The bioadhesive polymeric films as topical drug delivery systems are interesting alternatives to improve the pharmacotherapy and patient compliances. New derivate biomaterials based on weisocyanate- dendronized PVP- crosslinked chitosan and loaded with ciprofloxacin (CIP), as model drug, were used to prepare bioadhesive films. Relevant in vitro/in vivo attributes to define main physicochemical and biopharmaceutical characteristics for topical wound-healing applications were evaluated. A high proportion of CIP, uniformly dispersed along throughout the film, was loaded...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917707/amoebicidal-antimicrobial-and-in-vitro-ros-scavenging-activities-of-tunisian-rubus-ulmifolius-schott-methanolic-extract
#14
Soumaya Hajaji, Mohamed Amine Jabri, Ines Sifaoui, Atteneri López-Arencibia, María Reyes-Batlle, Fatma B'chir, Basilio Valladares, José E Pinero, Jacob Lorenzo-Morales, Hafidh Akkari
The present study aimed to evaluate the activity of methanolic extract of Rubus ulmifolius Schott against the Acanthamoeba castellani Neff Strain as well as its antioxidant and antimicrobial effects. The tested extract has a good amoebicidal activity with low IC50 (61.785 ± 1.322 μg/ml) and also has significant activity against both Gram-positive (S. aureus, S. agalactiae) and Gram-negative bacteria (E. coli, S. typhimurium) and against C. albicans. The inhibition zones diameters (IZD) and minimal inhibitory concentration (MIC) values were in the range of 22...
September 13, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28917118/calibration-of-the-comprehensive-ndha-n2o-dynamics-model-for-nitrifier-enriched-biomass-using-targeted-respirometric-assays
#15
Carlos Domingo-Félez, Maria Calderó-Pascual, Gürkan Sin, Benedek G Plósz, Barth F Smets
The NDHA model comprehensively describes nitrous oxide (N2O) producing pathways by both autotrophic ammonium oxidizing and heterotrophic bacteria. The model was calibrated via a set of targeted extant respirometric assays using enriched nitrifying biomass from a lab-scale reactor. Biomass response to ammonium, hydroxylamine, nitrite and N2O additions under aerobic and anaerobic conditions were tracked with continuous measurement of dissolved oxygen (DO) and N2O. The sequential addition of substrate pulses allowed the isolation of oxygen-consuming processes...
September 7, 2017: Water Research
https://www.readbyqxmd.com/read/28913577/a-resequencing-pathogen-microarray-method-for-high-throughput-molecular-diagnosis-of-multiple-etiologies-associated-with-central-nervous-system-infection
#16
Ji Wang, Panhui Yu, Zhengde Xie, Tengfei Yan, Chen Chen, Xinxin Shen, Xiangpeng Chen, Lixin Li, Xiuxia Wang, Suzhen Sun, Xuejun Ma
Central nervous system infection (CNSI) results in significant health and economic burdens worldwide, but the diversity of causative pathogens makes differential diagnosis very difficult. Although PCR and real-time fluorescent quantitative PCR (q-PCR) assays are widely applied for pathogen detection, they are generally optimized for the detection of a single or limited number of targets and are not suitable for the diagnosis of numerous CNSI agents. In this study, we describe the development of a resequencing pathogen microarray (RPM-IVDC4) method for the simultaneous detection of viruses, bacteria, fungi and parasites that cause CNSI...
September 14, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28912771/selection-of-functional-quorum-sensing-systems-by-lysogenic-bacteriophages-in-pseudomonas-aeruginosa
#17
Miguel A Saucedo-Mora, Paulina Castañeda-Tamez, Adrián Cazares, Judith Pérez-Velázquez, Burkhard A Hense, Daniel Cazares, Wendy Figueroa, Marco Carballo, Gabriel Guarneros, Berenice Pérez-Eretza, Nelby Cruz, Yoshito Nishiyama, Toshinari Maeda, Javier A Belmont-Díaz, Thomas K Wood, Rodolfo García-Contreras
Quorum sensing (QS) in Pseudomonas aeruginosa coordinates the expression of virulence factors, some of which are used as public goods. Since their production is a cooperative behavior, it is susceptible to social cheating in which non-cooperative QS deficient mutants use the resources without investing in their production. Nevertheless, functional QS systems are abundant; hence, mechanisms regulating the amount of cheating should exist. Evidence that demonstrates a tight relationship between QS and the susceptibility of bacteria against the attack of lytic phages is increasing; nevertheless, the relationship between temperate phages and QS has been much less explored...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28912620/hormonal-contraception-and-the-development-of-autoimmunity-a-review-of-the-literature
#18
William V Williams
Estrogens and progestins are known to have profound effects on the immune system and may modulate the susceptibility to autoimmune diseases. A comprehensive literature search was carried out using PubMed for any of 153 autoimmune disease terms and the terms contraception, contraceptive, or their chemical components with limits of Humans + Title or Abstract. Over 1,800 titles were returned and scanned, 352 papers retrieved and reviewed in depth and an additional 70 papers retrieved from the bibliographies. Based on this review, substantial evidence exists linking the use of combined oral contraceptives to a lower incidence of hyperthyroidism, an increase in multiple sclerosis, ulcerative colitis, Crohn's disease, Systemic Lupus Erythematosus, and interstitial cystitis...
August 2017: Linacre Quarterly
https://www.readbyqxmd.com/read/28910379/a-one-year-prospective-study-of-colonization-with-antimicrobial-resistant-organisms-on-admission-to-a-vietnamese-intensive-care-unit
#19
Duong Bich Thuy, James Campbell, Nguyen Van Minh Hoang, Truong Thi Thuy Trinh, Ha Thi Hai Duong, Nguyen Chi Hieu, Nguyen Hoang Anh Duy, Nguyen Van Hao, Stephen Baker, Guy E Thwaites, Nguyen Van Vinh Chau, C Louise Thwaites
There is a paucity of data regarding initial bacterial colonization on admission to Intensive Care Units (ICUs) in low and middle-income countries (LMICs). Patients admitted to ICUs in LMICs are at high-risk of subsequent infection with antimicrobial-resistant organisms (AROs). We conducted a prospective, observational study at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam from November 2014 to January 2016 to assess the colonization and antimicrobial susceptibility of Staphylococcus aureus, Escherichia coli, Klebsiella spp...
2017: PloS One
https://www.readbyqxmd.com/read/28904757/social-dilemma-in-the-external-immune-system-of-the-red-flour-beetle-it-is-a-matter-of-time
#20
Chaitanya S Gokhale, Arne Traulsen, Gerrit Joop
Sociobiology has revolutionized our understanding of interactions between organisms. Interactions may present a social dilemma where the interests of individual actors do not align with those of the group as a whole. Viewed through a sociobiological lens, nearly all interactions can be described regarding their costs and benefits, and a number of them then resemble a social dilemma. Numerous experimental systems, from bacteria to mammals, have been proposed as models for studying such dilemmas. Here, we make use of the external immune system of the red flour beetle, Tribolium castaneum, to investigate how the experimental duration can affect whether the external secretion comprises a social dilemma or not...
September 2017: Ecology and Evolution
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