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https://www.readbyqxmd.com/read/28239630/from-attachment-to-independence-stress-hormone-control-of-ecologically-relevant-emergence-of-infants-responses-to-threat
#1
Adrienne Santiago, Chiye Aoki, Regina M Sullivan
Young infant rat pups learn to approach cues associated with pain rather than learning amygdala-dependent fear. This approach response is considered caregiver-seeking and ecologically relevant within the context of attachment. With maturation, increases in the stress hormone corticosterone permit amygdala-dependent fear, which is crucial for survival during independent living. During the developmental transition from attachment to fear learning, maternal presence suppresses corticosterone elevation to block amygdala-dependent fear learning and re-engage the attachment circuitry...
April 2017: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/28238078/phase-i-study-of-pazopanib-plus-th-302-in-advanced-solid-tumors
#2
Richard F Riedel, Kellen L Meadows, Paula H Lee, Michael A Morse, Hope E Uronis, Gerard C Blobe, Daniel J George, Jeffrey Crawford, Donna Niedzwiecki, Christel N Rushing, Christy C Arrowood, Herbert I Hurwitz
PURPOSE: To define the maximum tolerated dose (MTD), recommended phase II dose (RPTD), and assess safety and tolerability for the combination of pazopanib plus TH-302, an investigational hypoxia-activated prodrug (HAP), in adult patients with advanced solid tumors. METHODS: This was an open-label, non-randomized, single-center, phase I trial consisting 2 stages. Stage 1 was a standard "3 + 3" dose escalation design to determine safety and the RPTD for TH-302 plus pazopanib combination...
February 25, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28237807/effects-of-paclitaxel-on-the-development-of-neuropathy-and-affective-behaviors-in-the-mouse
#3
Wisam Toma, S Lauren Kyte, Deniz Bagdas, Yasmin Alkhlaif, Shakir D Alsharari, Aron H Lichtman, Zhi-Jian Chen, Egidio Del Fabbro, John W Bigbee, David A Gewirtz, M Imad Damaj
Paclitaxel, one of the most commonly used cancer chemotherapeutic drugs, effectively extends the progression-free survival of breast, lung, and ovarian cancer patients. However, paclitaxel and other chemotherapy drugs elicit peripheral nerve fiber dysfunction or degeneration that leads to peripheral neuropathy in a large proportion of cancer patients. Patients receiving chemotherapy also often experience changes in mood, including anxiety and depression. These somatic and affective disorders represent major dose-limiting side effects of chemotherapy...
February 22, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28237612/effects-of-chondroitin-sulfate-on-brain-response-to-painful-stimulation-in-knee-osteoarthritis-patients-a-randomized-double-blind-placebo-controlled-functional-magnetic-resonance-imaging-study
#4
Jordi Monfort, Jesús Pujol, Oren Contreras-Rodríguez, Jone Llorente-Onaindia, Marina López-Solà, Laura Blanco-Hinojo, Josep Vergés, Marta Herrero, Laura Sánchez, Hector Ortiz, Francisco Montañés, Joan Deus, Pere Benito
INTRODUCTION: Knee osteoarthritis is causing pain and functional disability. One of the inherent problems with efficacy assessment of pain medication was the lack of objective pain measurements, but functional magnetic resonance imaging (fMRI) has emerged as a useful means to objectify brain response to painful stimulation. We have investigated the effect of chondroitin sulfate (CS) on brain response to knee painful stimulation in patients with knee osteoarthritis using fMRI. METHODS: Twenty-two patients received CS (800mg/day) and 27 patients placebo, and were assessed at baseline and after 4 months of treatment...
February 22, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28237610/visceral-and-bone-metastases-of-a-who-grade-2-meningioma-a-case-report-and-review-of-the-literature
#5
A Paix, W Waissi, D Antoni, R Adeduntan, G Noël
Meningiomas represent the most common tumours of the central nervous system in adults. Risk factors include ionizing radiation, female hormones exposure, head trauma, cell phone use, breast cancer and family history of meningioma. Despite complete surgical resection, natural history of meningiomas often includes local recurrence but very few metastatic meningiomas have been reported. Here, we report the case of a metastatic meningioma. A 43-year-old woman was firstly treated for a symptomatic parietal meningioma WHO grade II by surgical resection followed by an irradiation of the surgical bed...
February 22, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28237514/allodynia-lowering-induced-by-cannabinoids-and-endocannabinoids-alice
#6
REVIEW
Livio Luongo, Katarzyna Starowicz, Sabatino Maione, Vincenzo Di Marzo
Neuropathic pain is a neurological disorder that strongly affects the quality of life of patients. The molecular and cellular mechanisms at the basis of the neuropathic pain establishment still need to be clarified. Among the neuromodulators involved in the pathological pain pathways, endocannabinoid system could be deeply involved in both neuronal and non-neuronal mechanisms responsible for the appearance of tactile allodynia. Indeed, the function and dysfunction of this complex system in the molecular and cellular mechanisms of chronic pain induction and maintenance has been widely studied over the last two decades...
February 22, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28237371/pain-locations-in-the-postoperative-period-after-cardiac-surgery-chronology-of-pain-and-response-to-treatment
#7
J Roca, R Valero, C Gomar
INTRODUCTION: Postoperative pain after cardiac surgery (CS) can be generated at several foci besides the sternotomy. METHODS: Prospective descriptive longitudinal study on the chronological evolution of pain in 11 sites after CS including consecutive patients submitted to elective CS through sternotomy. The primary endpoints were to establish the main origins of pain, and to describe its chronological evolution during the first postoperative week. Secondary endpoints were to describe pain characteristics in the sternotomy area and to correlate pain intensity with other variables...
February 22, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28237081/incidence-of-posterior-interosseous-nerve-trauma-during-creation-of-the-3-4-wrist-arthroscopy-portal-in-cadavers
#8
Andre Eu-Jin Cheah, Wei Le, Jeffrey Yao
PURPOSE: To describe histologic evidence of nerve trauma during the creation and use of the 3-4 portal. METHODS: Fourteen fresh-frozen cadaveric wrists were mounted on a custom-built frame that simulated a wrist arthroscopy traction tower. After the 3-4 portal was created in the usual manner, the skin was dissected off to identify possible trauma to the posterior interosseous nerve (PIN). Specimens were categorized into those where there was clearly no trauma to the PIN and those where trauma was possible...
February 22, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28236520/frequency-and-prognosis-of-acute-pancreatitis-associated-with-fulminant-or-non-fulminant-acute-hepatitis-a-a-systematic-review
#9
Samir Haffar, Fateh Bazerbachi, Larry Prokop, Kymberly D Watt, M Hassan Murad, Suresh T Chari
BACKGROUND: Acute pancreatitis (AP) in patients with fulminant viral hepatitis is well recognized and its mortality depends on the severity of hepatitis rather than pancreatitis. Acute pancreatitis associated with non-fulminant acute hepatitis A (AHA) has been rarely described, and is considered to have a benign course with good response to conservative management. OBJECTIVE: To perform a systematic review of the frequency and prognosis of AP associated with fulminant or non-fulminant AHA...
February 17, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28236513/remote-management-of-low-to-intermediate-risk-chest-pain-a-case-series
#10
Alexander Chiu, Kathleen Shumaker, Christopher Del Corral, Blessy George, Michael Kasper, Elie Marie-Carmelle, Preeti Jois, Daniel Dipsia, Adam Ash
We report a case series of three low to intermediate risk chest pain patients who presented to the emergency department and were managed as outpatients via the Cellular Outpatient Twelve-Lead Telemetry with Emergency Response (COTTER™). This technology allows for certain chest pain patients to be managed remotely via telemedicine while receiving care comparable to that which would be available in a hospital or chest pain observation unit.
February 16, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28236471/erectile-dysfunction-in-patients-with-chronic-pain-treated-with-opioids
#11
Raquel Ajo, Ana Segura, María-Del-Mar Inda, César Margarit, Pura Ballester, Emi Martínez, Guillermina Ferrández, Ángel Sánchez-Barbie, Ana M Peiró
INTRODUCTION AND OBJECTIVE: Chronic pain is associated with comorbidities that have an impact on the quality of life of patients and, among others, affect their sexual functioning. One of the most relevant side effects of opioid analgesics is erectile dysfunction (ED), due in part to the inhibition of the gonadal-pituitary-hypothalamic axis and the decline in testosterone levels. To evaluate ED and effectiveness of treatment in men with chronic pain treated with long-term opioids. MATERIAL AND METHODS: Prospective observational study lasting 3 years, where the intensity of pain (visual analogue scale, 0-10cm), erectile function (IIEF-EF, range 1-30 points), quality of life (EQ-VAS, 0-100mm), quality of sexual life (MSLQ-QOL, 0-100 points), anxiety/depression (HAD, 0-21 points) and testosterone levels, was assessed in patients who reported sexual dysfunction (ED or libido modification)...
February 21, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28231466/leaky-gate-model-intensity-dependent-coding-of-pain-and-itch-in-the-spinal-cord
#12
Shuohao Sun, Qian Xu, Changxiong Guo, Yun Guan, Qin Liu, Xinzhong Dong
Coding of itch versus pain has been heatedly debated for decades. However, the current coding theories (labeled line, intensity, and selectivity theory) cannot accommodate all experimental observations. Here we identified a subset of spinal interneurons, labeled by gastrin-releasing peptide (Grp), that receive direct synaptic input from both pain and itch primary sensory neurons. When activated, these Grp(+) neurons generated rarely seen, simultaneous robust pain and itch responses that were intensity dependent...
February 22, 2017: Neuron
https://www.readbyqxmd.com/read/28231458/gate-control-theory-springs-a-leak
#13
Paula J S Pereira, Ethan A Lerner
Sun and colleagues (2017) find that individual Grp+ spinal interneurons can respond to and distinguish between stimuli that provoke itch or pain. The nociceptive response is limited by enkaphalin-expressing interneurons that are connected synaptically to the Grp+ neurons.
February 22, 2017: Neuron
https://www.readbyqxmd.com/read/28231274/early-skin-to-skin-contact-after-cesarean-section-a-randomized-clinical-pilot-study
#14
Martina Kollmann, Lisa Aldrian, Anna Scheuchenegger, Eva Mautner, Sereina A Herzog, Berndt Urlesberger, Reinhard B Raggam, Uwe Lang, Barbara Obermayer-Pietsch, Philipp Klaritsch
OBJECTIVE: Early bonding by skin-to-skin contact (SSC) has been demonstrated to be beneficial for mothers and newborns following vaginal delivery. The aim of this study was to investigate the impact of intraoperative bonding (early SSC) after cesarean section on neonatal adaptation, maternal pain and stress response. STUDY DESIGN: This prospective, randomized-controlled pilot study was performed at a single academic tertiary hospital (Department of Obstetrics and Gynecology, Medical University of Graz, Austria) between September 2013 and January 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28230331/the-development-and-assessment-of-the-worry-about-pain-questionnaire
#15
J C Lefebvre, M P Jensen, S J Waters, I R Molton, F J Keefe, D S Caldwell
BACKGROUND: Worry can be conceptualized as a cognitive-affective automatic process initiated in order to address uncertainty and potential personal inadequacies that could result in negative outcomes. The purpose of the current study was to develop a measure of pain-specific worry - the Worry About Pain Questionnaire (WAPQ). METHOD: In study 1, responses of 335 pain-free participants were used to complete an item analysis and exploratory factors analysis to develop and assess the internal structure of the WAPQ...
February 23, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28230292/age-related-changes-in-pain-sensitivity-in-healthy-humans-a-systematic-review-with-meta-analysis
#16
REVIEW
H El Tumi, M I Johnson, P B F Dantas, M J Maynard, O A Tashani
: Literature suggests that pain perception diminishes in old age. The most recent review used search strategies conducted over a decade ago and concluded that study findings were equivocal. The aim of this systematic review, with meta-analysis, was to determine age-related changes in pain sensitivity in healthy pain-free adults, children and adolescents. A search of PubMed, Science Direct, and PsycINFO identified studies that compared pain sensitivity response to noxious stimuli at different time points in the lifespan of healthy individuals...
February 23, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28229610/coping-with-celiac-disease-how-heavy-is-the-burden-for-caregivers
#17
Francesca Ferretti, Federica Branchi, Bernardo Dell'Osso, Dario Conte, Luca Elli
BACKGROUND: Celiac disease (CD) is the most common chronic enteropathy demanding a lifelong gluten-free diet. OBJECTIVE: The aim of the study was to identify and estimate the subjective burden of caregivers of celiac patients. METHODS: A cross-sectional observational study was conducted during the regional meeting of the Italian Society for the Celiac Disease in April 2014. A written self-administered anonymous questionnaire enquired into caregivers' demographic profile, natural history of patients' disease and caregivers' self-reported degree of burden at the onset of symptoms (T0), at CD diagnosis (T1) and during follow-up (T2)...
February 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28229377/important-treatment-outcomes-for-patients-with-psoriatic-arthritis-a-multisite-qualitative-study
#18
Emma Dures, Sarah Hewlett, Jane Lord, Clive Bowen, Neil McHugh, William Tillett
BACKGROUND: Psoriatic arthritis (PsA) is a variable and complex inflammatory condition. Symptoms can compromise physical function, reduce quality of life, and accrue significant health costs. Commonly used patient-reported outcomes largely reflect the professionals' perspective, however it is not known whether they capture what is important to patients. OBJECTIVE: The aim of our study was to identify treatment outcomes important to patients with PsA. METHODS: Eight focus groups that were audio recorded, transcribed, anonymised and analysed using inductive thematic analysis were conducted at five hospital sites...
February 22, 2017: Patient
https://www.readbyqxmd.com/read/28228794/prompt-clinical-and-biochemical-response-to-denosumab-in-a-young-adult-patient-with-craniofacial-fibrous-dysplasia
#19
Cristina Eller-Vainicher, Diego Sergio Rossi, Giuseppe Guglielmi, Giada Anna Beltramini, Elisa Cairoli, Antonio Russillo, Giovanna Mantovani, Anna Spada, Iacopo Chiodini
BACKGROUND: We report on the clinical and biochemical outcomes in a 20-year-old male suffering from active craniofacial monostotic fibrous dysplasia (MFD) of the left mandible treated with the RANK-L inhibitor, denosumab, following unsatisfactory responses to prior long-term bisphosphonates therapy. RESULTS: The patient had been treated over 9 years with pamidronate (cumulative dose of 810 mg) with incomplete control of pain. Following initiation of denosumab 60 mg subcutaneously, bone pain and bone turnover markers (osteocalcin, total and bone alkaline phosphatase and carboxy-terminal cross-linking telopeptide of type I collagen) were monitored over a 27 months period...
September 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28228431/right-upper-quadrant-abdominal-pain-as-the-initial-presentation-of-polyarteritis-nodosa
#20
Ricardo Gago, Lee Ming Shum, Luis M Vilá
Polyarteritis nodosa (PAN) is a necrotising vasculitis that involves medium and small vessels. PAN generally presents with constitutional, cutaneous, neurological, renal and gastrointestinal manifestations. However, PAN initially involving a single organ/system is uncommon. Here, we present a 42-year-old man who was hospitalised because of severe right upper quadrant abdominal pain that started 2 months before. Physical examination was remarkable for right upper quadrant abdominal tenderness. Abdominopelvic CT showed lymphadenopathy but no hepatic, gallbladder, pancreatic, intestinal or renal abnormalities...
February 22, 2017: BMJ Case Reports
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