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https://www.readbyqxmd.com/read/28641716/the-effects-of-pleural-plaques-on-longitudinal-lung-function-in-vermiculite-miners-of-libby-montana
#1
Kathleen A Clark, J Jay Flynn, Wilfried J J Karmaus, Lawrence C Mohr
BACKGROUND: This study was conducted to assess associations of pleural plaques (PP) and longitudinal lung function in vermiculite miners of Libby, Montana who are occupationally exposed to asbestos. High-resolution computed tomography (HRCT) was used to identify asbestos-related findings in former Libby vermiculite miners. We investigated annual lung function decline in miners with PP only and compared them to miners with normal HRCT findings. MATERIALS AND METHODS: HRCTs from 128 miners were categorized into the following 4 diagnostic groups: (1) normal computed tomography scan (n = 9); (2) PP only (n = 72); (3) PP and interstitial fibrosis (n = 26) and (4) additional HRCT abnormalities (n = 21) such as rounded atelectasis, diffuse pleural thickening, pleural effusions or pulmonary nodules or tumor >1cm in diameter...
June 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28638254/inflammation-and-oxidation-biomarkers-in-patients-with-cystic-fibrosis-the-influence-of-azithromycin
#2
Casilda Olveira, Alicia Padilla, Antonio Dorado, Victoria Contreras, Eduardo Garcia-Fuentes, Elehazara Rubio-Martin, Nuria Porras, Esperanza Doña, Ana Carmona, Gabriel Olveira
OBJECTIVE: In addition to their antibiotic effect, macrolides appear to modulate the inflammatory response in cystic fibrosis (CF) and could influence oxidative stress. The objective of this study was to assess oxidation biomarkers and levels of inflammation and to determine whether there is an association between these parameters and the intake of macrolides. MATERIALS AND METHODS: The subjects included in this cross-sectional study were, on the one hand, clinically stable patients with CF and, on the other, healthy controls...
June 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28636794/differences-and-similarities-between-bronchopulmonary-dysplasia-and-asthma-in-schoolchildren
#3
Björn Nordlund, Anna James, Christina Ebersjö, Gunilla Hedlin, Eva B Broström
BACKGROUND: The long-term respiratory characteristics of ex-preterm children with bronchopulmonary dysplasia (BPD) are not established. The objective of this study was to describe hallmarks of BPD at school age in comparison to children with atopic asthma. METHODS: This study was a cross-sectional descriptive comparative study in a hospital-based setting. Thirty schoolchildren diagnosed with BPD (10.4 years/born at 26.6 weeks' gestation) and 30 age- and sex-matched children with asthma and sensitized to airborne allergens (IgE >0...
June 21, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28636526/does-health-coaching-grow-capacity-in-cancer-survivors-a-systematic-review
#4
Suzette Barakat, Kasey Boehmer, Marwan Abdelrahim, Sangwoo Ahn, Abdulrahman A Al-Khateeb, Neri Álvarez Villalobos, Larry Prokop, Patricia J Erwin, Kirsten Fleming, Valentina Serrano, Gabriela Spencer-Bonilla, Mohammad Hassan Murad
Interventions that grow patient capacity to do the work of health care and life are needed to support the health of cancer survivors. Health coaching may grow capacity. This systematic review of health coaching interventions explored coaching's ability to grow capacity of cancer survivors. The authors included randomized trials or quasi-experimental studies comparing coaching to alternative interventions, and adhered to PRISMA reporting guidelines. Data were analyzed using the Theory of Patient Capacity (BREWS: Capacity is affected by factors that influence ability to reframe Biography ["B"], mobilize or recruit Resources ["R"], interact with the Environment of care ["E"], accomplish Work ["W"]), and function Socially ["S"])...
June 21, 2017: Population Health Management
https://www.readbyqxmd.com/read/28633879/intensive-preoperative-rehabilitation-improves-functional-capacity-and-postoperative-hospital-length-of-stay-in-elderly-patients-with-lung-cancer-commentary
#5
https://www.readbyqxmd.com/read/28630566/the-global-lung-function-initiative-2012-equations-are-as-well-suited-as-local-population-derived-equations-to-a-sample-of-healthy-professional-firefighters
#6
Flynn Slattery, Tjard Schermer, Adrian Esterman, Kylie Johnston, Alan Crockett
BACKGROUND AND OBJECTIVE: We aimed to assess the validity of using the Global Lung Function Initiative's (GLI) 2012 equations to interpret lung function data in a healthy workforce of South Australian Metropolitan Fire Service (SAMFS) personnel. METHODS: Spirometry data from 212 healthy, nonsmoking SAMFS firefighters were collected and predicted normal values were calculated using both the GLI and local population derived (Gore) equations for forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28629919/comparing-pulmonary-nodule-location-during-electromagnetic-bronchoscopy-with-predicted-location-based-on-two-virtual-airway-maps-at-different-phases-of-respiration
#7
Brian S Furukawa, Nicholas J Pastis, Nichole T Tanner, Alexander Chen, Gerard A Silvestri
BACKGROUND: Electromagnetic navigational bronchoscopy (ENB) is guided-bronchoscopy to pulmonary nodules (PN) which relies on a pre-procedural chest CT to create a 3-dimensional (3-D) virtual airway map. The CT is traditionally done at a full inspiratory breath hold (INSP) but the procedure is performed while the patient tidal breaths, where lung volumes are closer to functional residual capacity. Movement of a PN from INSP to expiration (EXP) has been shown to average 17.6 mm. Therefore, the hypothesis of this study is that pre-procedural virtual maps built off a CT closer to physiological lung volumes during bronchoscopy may better represent the actual 3-D location of a PN...
June 16, 2017: Chest
https://www.readbyqxmd.com/read/28629803/development-of-mpc-dpa-polymeric-nanoparticle-systems-for-inhalation-drug-delivery-applications
#8
Abdul Khaliq Elzhry Elyafi, Guy Standen, Steven T Meikle, Andrew L Lewis, Jonathan P Salvage
Inhalation of nanoparticles for pulmonary drug delivery offers the potential to harness nanomedicine formulations of emerging therapeutics, such as curcumin, for treatment of lung cancer. Biocompatible nanoparticles composed of poly(2-methacryloyloxyethyl phosphorylcholine)-b-poly(2-(diisopropylamino)ethyl methacrylate) (MPC-DPA) have been shown to be suitable nanocarriers for drugs, whilst N-trimethyl chitosan chloride (TMC) coating of nanoparticles has been reported to further enhance their cellular delivery efficacy; the combination of the two has not been previously investigated...
June 16, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28626727/mast-cell-infiltration-in-human-brain-metastases-modulates-the-microenvironment-and-contributes-to-the-metastatic-potential
#9
Ananya Roy, Sylwia Libard, Holger Weishaupt, Ida Gustavsson, Lene Uhrbom, Göran Hesselager, Fredrik J Swartling, Fredrik Pontén, Irina Alafuzoff, Elena Tchougounova
Metastatic brain tumors continue to be a clinical problem, despite new therapeutic advances in cancer treatment. Brain metastases (BMs) are among the most common mass lesions in the brain that are resistant to chemotherapies, have a very poor prognosis, and currently lack any efficient diagnostic tests. Predictions estimate that about 40% of lung and breast cancer patients will develop BM. Despite this, very little is known about the immunological and genetic aberrations that drive tumorigenesis in BM. In this study, we demonstrate the infiltration of mast cells (MCs) in a large cohort of human BM samples with different tissues of origin for primary cancer...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28624884/age-at-menarche-and-lung-function-a-mendelian-randomization-study
#10
Dipender Gill, Nuala A Sheehan, Matthias Wielscher, Nick Shrine, Andre F S Amaral, John R Thompson, Raquel Granell, Bénédicte Leynaert, Francisco Gómez Real, Ian P Hall, Martin D Tobin, Juha Auvinen, Susan M Ring, Marjo-Riitta Jarvelin, Louise V Wain, John Henderson, Deborah Jarvis, Cosetta Minelli
A trend towards earlier menarche in women has been associated with childhood factors (e.g. obesity) and hypothesised environmental exposures (e.g. endocrine disruptors present in household products). Observational evidence has shown detrimental effects of early menarche on various health outcomes including adult lung function, but these might represent spurious associations due to confounding. To address this we used Mendelian randomization where genetic variants are used as proxies for age at menarche, since genetic associations are not affected by classical confounding...
June 17, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28623944/the-effect-of-combining-manual-therapy-with-exercise-for-mild-chronic-obstructive-pulmonary-disease-study-protocol-for-a-randomised-controlled-trial
#11
Roger M Engel, Jaxson Wearing, Peter Gonski, Subramanyam Vemulpad
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major cause of disability and hospital admission. Current management strategies have not been successful in altering the loss of lung function typically seen as the disease progresses. A recent systematic review into the use of spinal manipulative therapy (SMT) in the management of COPD concluded that there was low level evidence to support the view that a combination of SMT and exercise had the potential to improve lung function more than exercise alone in people with moderate to severe COPD...
June 17, 2017: Trials
https://www.readbyqxmd.com/read/28622568/per-protocol-investigation-of-a-best-practice-exercise-referral-scheme
#12
L Stewart, E Dolan, P Carver, P A Swinton
OBJECTIVES: To investigate the effects of an exercise referral scheme (ERS) aligned to the UK best practice guidelines on a range of outcomes including those associated with key health concerns of the Scottish population. STUDY DESIGN: A longitudinal design with data collection at three time points (baseline, midway and post) during a 12-week ERS intervention was employed. METHODS: Health-related physical fitness was assessed through measurement of resting heart rate, blood pressure, FEV1:FEV6 (ratio of forced expiratory volume over one [FEV1] and six [FEV6] seconds), body mass and peak oxygen uptake (VO2 peak), whilst functional capacity was assessed through the five times sit to stand test...
June 12, 2017: Public Health
https://www.readbyqxmd.com/read/28621617/intrathoracic-meningocele-associated-with-neurofibromatosis-type-1-and-a-novel-technique-for-surgical-repair-case-report
#13
Paramita Das, Tarini Goyal, Matthew A Hunt
Neurofibromatosis Type 1 (NF1) is a neurocutaneous disorder that can have associated spinal abnormalities related to both bone and dural dysplasia. Thoracic meningoceles are one spine anomaly associated with NF1, although they are a fairly uncommon pathology. Surgical techniques to treat these meningoceles, usually undertaken only when the patient is symptomatic, are targeted at decreasing the size of the protrusion and improving lung capacity. Surgical interventions discussed in the literature include shunting the pseudomeningocele, primary repair with laminectomy, thoracoscopic plication, and reinforcement of the closure with cement, muscle, or fascia...
June 16, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28621160/epigenome-wide-association-study-of-chronic-obstructive-pulmonary-disease-and-lung-function-in-koreans
#14
Mi Kyeong Lee, Yoonki Hong, Sun-Young Kim, Woo Jin Kim, Stephanie J London
AIM: To identify differentially methylated probes (DMPs) and regions (DMRs) in relation to chronic obstructive pulmonary disease (COPD) and lung function traits. METHODS: We performed an epigenome-wide association study of COPD and spirometric parameters, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC, in blood DNA using the Infinium HumanMethylation450 (n = 100, a Korean COPD cohort). RESULTS: We found one significant DMP (cg03559389, DIP2C) and 104 significant DMRs after multiple-testing correction...
June 16, 2017: Epigenomics
https://www.readbyqxmd.com/read/28620605/regulation-of-eosinophil-recruitment-and-activation-by-galectins-in-allergic-asthma
#15
REVIEW
Savita P Rao, Xiao Na Ge, P Sriramarao
Eosinophils are differentiated granulocytes that are recruited from the bone marrow to sites of inflammation via the vascular system. Allergic asthma is characterized by the presence of large numbers of eosinophils in the lungs and airways. Due to their capacity to rapidly release inflammatory mediators such as cytokines, chemokines, growth factors, and cytotoxic granule proteins upon stimulation, eosinophils play a critical role in pro-inflammatory processes in allergen-exposed lungs. Identifying key players and understanding the molecular mechanisms directing eosinophil trafficking and recruitment to inflamed airways is a key to developing therapeutic strategies to limit their influx...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28620140/comparison-of-tumor-biology-of-two-distinct-cell-sub-populations-in-lung-cancer-stem-cells
#16
Jianyu Wang, Zhiwei Sun, Yongli Liu, Liangsheng Kong, Shixia Zhou, Junlin Tang, Hongmei Rosie Xing
3Characterization of the stem-like properties of cancer stem cells (CSCs) remain indirect and qualitative, especially the ability of CSCs to undergo asymmetric cell division for self renewal and differentiation, a unique property of cells of stem origin. It is partly due to the lack of stable cellular models of CSCs. In this study, we developed a new approach for CSC isolation and purification to derive a CSC-enriched cell line (LLC-SE). By conducting five consecutive rounds of single cell cloning using the LLC-SE cell line, we obtained two distinct sub-population of cells within the Lewis lung cancer CSCs that employed largely symmetric division for self-renewal (LLC-SD) or underwent asymmetric division for differentiation (LLC-ASD)...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28619955/pulmonary-artery-to-aorta-ratio-and-risk-of-all-cause-mortality-in-the-general-population-the-rotterdam-study
#17
Natalie Terzikhan, Daniel Bos, Lies Lahousse, Lennard Wolff, Katia M C Verhamme, Maarten J G Leening, Janine F Felix, Henning Gall, Hossein A Ghofrani, Oscar H Franco, M Arfan Ikram, Bruno H Stricker, Aad van der Lugt, Guy Brusselle
A pulmonary artery to aorta ratio (PA:A) >1 is a proxy of pulmonary hypertension. It is not known whether this measure carries prognostic information in the general population and in individuals with chronic obstructive pulmonary disease (COPD).Between 2003 and 2006, 2197 participants from the population-based Rotterdam Study (mean±sd age 69.7±6.7 years; 51.3% female), underwent cardiac computed tomography (CT) scanning with PA:A quantification, defined as the ratio between the diameters of the pulmonary artery and the aorta...
June 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28619061/rituximab-versus-cyclophosphamide-for-the-treatment-of-connective-tissue-disease-associated-interstitial-lung-disease-recital-study-protocol-for-a-randomised-controlled-trial
#18
Peter Saunders, Vicky Tsipouri, Gregory J Keir, Deborah Ashby, Marcus D Flather, Helen Parfrey, Daphne Babalis, Elisabetta A Renzoni, Christopher P Denton, Athol U Wells, Toby M Maher
BACKGROUND: Interstitial lung disease (ILD) frequently complicates systemic autoimmune disorders resulting in considerable morbidity and mortality. The connective tissue diseases (CTDs) most frequently resulting in ILD include: systemic sclerosis, idiopathic inflammatory myositis (including dermatomyositis, polymyositis and anti-synthetase syndrome) and mixed connective tissue disease. Despite the development, over the last two decades, of a range of biological therapies which have resulted in significant improvements in the treatment of the systemic manifestations of CTD, the management of CTD-associated ILD has changed little...
June 15, 2017: Trials
https://www.readbyqxmd.com/read/28618971/inversin-correlates-with-the-malignant-phenotype-of-non-small-cell-lung-cancer-and-promotes-the-invasiveness-of-lung-cancer-cells
#19
Gui-Yang Jiang, Yong Zhang, Xiu-Peng Zhang, Xu-Yong Lin, Juan-Han Yu, En-Hua Wang
Inversin, encoded by NPHP2, is one of the 10 NPHP proteins known to be involved in nephronophthisis (an autosomal recessive cystic kidney). Although the previous reports showed that inversin played an important role in embryonic development and renal diseases, its function in cancer was not revealed clearly so far. As measured by immunohistochemical staining, inversin was highly expressed in the cytoplasm of lung cancer samples (63.4%, 161/254) compared with adjacent normal lung tissues (22.0%, 11/50, p < 0...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28617535/research-on-the-protective-effects-of-antioxidants-on-metabolic-syndrome-induced-by-thyroid-dysfunction
#20
Y Chen, Z Zhou, X-X Li, T Wang
OBJECTIVE: This paper researches on the protective effects of antioxidants on metabolic syndrome induced by thyroid dysfunction. While the role of Lipoic acid (LA), Resveratrol (R) and Quercetin (Q) are recognized, the mechanisms for their ameliorative effects are partially understood. Therefore, the objective of this study was to determine the prevalence of MS among university workers and to examine the relationship with thyroid function and mechanisms for protective effects of LA, Resveratrol and Quercetin on the heart, kidneys and lungs...
May 2017: European Review for Medical and Pharmacological Sciences
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