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Uric acid,cardio-renal syndrome

Silvia Lai, Mauro Ciccariello, Mira Dimko, Alessandro Galani, Silvio Lucci, Rosario Cianci, Amalia Mariotti
Bakground/Aims: Cardiovascular diseases represent the leading causes of morbidity and mortality in patients with cronich kidney disease (CKD). The pathogenesis includes a complex, bidirectional interaction between heart and kidney termed cardiorenal syndrome type 4. The aim of study was to evaluate the association between renal and cardiovascular ultrasonographic parameters and identify early markers of cardiovascular risk. METHODS: A total of 35 patients with CKD and 25 healthy controls, were enrolled and we have evaluated inflammatory indexes, mineral metabolism, renal function, renal and cardiovascular ultrasonographic parameters...
2016: Kidney & Blood Pressure Research
F Viazzi, D Garneri, G Leoncini, A Gonnella, M L Muiesan, E Ambrosioni, F V Costa, G Leonetti, A C Pessina, B Trimarco, M Volpe, E Agabiti Rosei, G Deferrari, R Pontremoli
BACKGROUND AND AIMS: The independent role of serum uric acid (SUA) as a marker of cardio-renal risk is debated. The aim of this study was to assess the relationship between SUA, metabolic syndrome (MS), and other cardiovascular (CV) risk factors in an Italian population of hypertensive patients with a high prevalence of diabetes. METHODS AND RESULTS: A total of 2429 patients (mean age 62 ± 11 years) among those enrolled in the I-DEMAND study were stratified on the basis of SUA gender specific quartiles...
August 2014: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Giorgio Sesti, Teresa Vanessa Fiorentino, Franco Arturi, Maria Perticone, Angela Sciacqua, Francesco Perticone
Evidence suggests that nonalcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are associated with an increased risk of chronic kidney disease (CKD). In this study we aimed to evaluate whether the severity of liver fibrosis estimated by NAFLD fibrosis score is associated with higher prevalence of CKD in individuals with NAFLD. To this end NAFLD fibrosis score and estimated glomerular filtration rate (eGFR) were assessed in 570 White individuals with ultrasonography-diagnosed NAFLD...
2014: PloS One
Takamasa Sato, Hiroyuki Yamauchi, Satoshi Suzuki, Akiomi Yoshihisa, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-Ichi Saitoh, Yasuchika Takeishi
Impaired renal function is a strong predictor of mortality in chronic heart failure (CHF). However, the impact of chronic kidney disease (CKD) on prognostic factors has not been rigorously examined in CHF. The purpose of this study was to compare prognostic factors between CHF patients with and without CKD. Consecutive 505 patients with CHF, who performed cardiopulmonary exercise testing before discharge, were enrolled. Patients were divided into two groups: CKD group (eGFR < 60 mL/minute/1.73 m2, n = 213) and non-CKD group (eGFR ≥ 60 mL/minute/1...
2013: International Heart Journal
Manfredi Rizzo, Milan Obradovic, Milica Labudovic-Borovic, Dragana Nikolic, Giuseppe Montalto, Ali A Rizvi, Dimitri P Mikhailidis, Esma R Isenovic
In humans uric acid (UA) is the end product of degradation of purines. The handling of UA by the renal system is a complex process which is not fully understood. To date, several urate transporters in the renal proximal tubule have been identified. Among them, urate transporter 1 (URAT1) and a glucose transporter 9 (GLUT9) are considered of greater importance, as potential targets for treatment of hyperuricemia and the potential associated cardio-metabolic risk. Therefore, the recognition of the metabolic pathway of UA and elucidation of occurrence of hyperuricemia may provide important insights about the relationship between UA, pre-hypertension (preHT) and the metabolic syndrome (MetS)...
2014: Current Vascular Pharmacology
Marc Kaufman, Maya Guglin
There is a need for a cost-effective prognostic biomarker in heart failure (HF). Substantial evidence suggests that uric acid (UA) is an independent marker for adverse prognosis in acute and chronic HF of varying severity. Whether UA is a merely a marker of poor prognosis or is an active participant in disease pathogenesis is currently unknown. In the setting of HF, at least two different processes can be responsible for increased UA: increased production, which may result from oxidative stress, and decreased excretion due to renal insufficiency, which can be a consequence of cardio-renal syndrome, renal congestion, or comorbidities...
March 2013: Heart Failure Reviews
Richard J Johnson, Miguel A Lanaspa, Eric A Gaucher
All human beings are uricase knockouts; we lost the uricase gene as a result of a mutation that occurred in the mid-Miocene epoch approximately 15 million years ago. The consequence of being a uricase knockout is that we have higher serum uric acid levels that are less regulatable and can be readily influenced by diet. This increases our risk for gout and kidney stones, but there is also increasing evidence that uric acid increases our risk for hypertension, kidney disease, obesity, and diabetes. This raises the question of why this mutation occurred...
September 2011: Seminars in Nephrology
Richard J Johnson, Mehmet Kanbay, Laura Gabriela Sánchez-Lozada
No abstract text is available yet for this article.
September 2011: Seminars in Nephrology
Davide Stellato, Luigi Francesco Morrone, Chiara Di Giorgio, Loreto Gesualdo
Elevated uric acid levels are a common finding in patients with metabolic syndrome and in those with cardiovascular and renal disease, but the meaning of this elevation is still unclear. In patients with chronic kidney diseases, it could merely reflect the reduction in glomerular filtration rate: but uric acid levels are known to be elevated in people, also in younger ones, prior to the development of hypertension or renal disease, independently of several risk factors. Multiple potential mechanisms suggest a causative role for uric acid in vascular disease...
February 2012: Internal and Emergency Medicine
Christine Gersch, Sergiu P Palii, Witcha Imaram, Kyung Mee Kim, S Ananth Karumanchi, Alexander Angerhofer, Richard J Johnson, George N Henderson
Hyperuricemia is associated with hypertension, metabolic syndrome, preeclampsia, cardio-vascular disease and renal disease, all conditions associated with oxidative stress. We hypothesized that uric acid, a known antioxidant, might become prooxidative following its reaction with oxidants; and, thereby contribute to the pathogenesis of these diseases. Uric acid and 1,3-(15)N(2)-uric acid were reacted with peroxynitrite in different buffers and in the presence of alcohols, antioxidants and in human plasma. The reaction products were identified using liquid chromatography-mass spectrometry (LC-MS) analyses...
February 2009: Nucleosides, Nucleotides & Nucleic Acids
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