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https://www.readbyqxmd.com/read/29348826/interaction-of-macrophages-with-apoptotic-cells-inhibits-transdifferentiation-and-invasion-of-lung-fibroblasts
#1
Yong-Bae Kim, Young-So Yoon, Youn-Hee Choi, Eun-Mi Park, Jihee Lee Kang
The invasion of activated fibroblasts is a key mechanism of tissue fibrosis pathology. The recognition and uptake of apoptotic cells can induce the anti-fibrogenic programming of macrophages. We demonstrate that after interacting with apoptotic cells, macrophages secrete bioactive molecules that antagonize TGF-β1-induced increases in myofibroblast (fibroproliferative) phenotypic markers and reduce the enhanced invasive capacity of TGF-β1- or EGF-treated mouse lung fibroblasts (MLg). Furthermore, numerous treatment strategies prevented the anti-fibrotic effects of conditioned media, including transfection of macrophages with COX-2 or RhoA siRNAs or treatment of MLg cells with receptor antagonists for prostaglandin E2 (PGE2), PGD2, or hepatocyte growth factor (HGF)...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29346833/phase-1b-trial-of-ficlatuzumab-a-humanized-hepatocyte-growth-factor-inhibitory-monoclonal-antibody-in-combination-with-gefitinib-in-asian-patients-with-nsclc
#2
Eng-Huat Tan, Wan-Teck Lim, Myung-Ju Ahn, Quan-Sing Ng, Jin Seok Ahn, Daniel Shao-Weng Tan, Jong-Mu Sun, May Han, Francis C Payumo, Krista McKee, Wei Yin, Marc Credi, Shefali Agarwal, Jaroslaw Jac, Keunchil Park
Hepatocyte growth factor (HGF)/c-Met pathway dysregulation is a mechanism for epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). Ficlatuzumab (AV-299; SCH 900105), a humanized IgG1 κ HGF inhibitory monoclonal antibody, prevents HGF/c-Met pathway ligand-mediated activation. This phase 1b study assessed the safety/tolerability, pharmacokinetics/pharmacodynamics, and antitumor activity of ficlatuzumab plus gefitinib in Asian patients with previously treated advanced non-small cell lung cancer (NSCLC)...
January 18, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29345253/3-acetyl-oleanolic-acid-ameliorates-non-alcoholic-fatty-liver-disease-in-high-fat-diet-treated-rats-by-activating-ampk-related-pathways
#3
Qiong Ou-Yang, Chun-Xiao Xuan, Xue Wang, Han-Qiong Luo, Jin-E Liu, Lan-Lan Wang, Ting-Ting Li, Yu-Peng Chen, Jun Liu
3-Acetyl-oleanolic acid (3Ac-OA) is a derivative of oleanolic acid (OA), which has shown therapeutic beneficial effects on diabetes and metabolic syndrome. In this study we investigated whether 3Ac-OA exerted beneficial effect on non-alcoholic fatty liver disease (NAFLD) in rats and its potential underlying mechanisms. Treatment with 3Ac-OA (1-100 μmol/L) dose-dependently decreased the intracellular levels of total cholesterol (TC) and triglyceride (TG) in FFA-treated primary rat hepatocytes and human HepG2 cell lines in vitro...
January 18, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29343699/collagen-binding-hepatocyte-growth-factor-hgf-alone-or-with-a-gelatin-furfurylamine-hydrogel-enhances-functional-recovery-in-mice-after-spinal-cord-injury
#4
Kentaro Yamane, Tetsuro Mazaki, Yasuyuki Shiozaki, Aki Yoshida, Kensuke Shinohara, Mariko Nakamura, Yasuhiro Yoshida, Di Zhou, Takashi Kitajima, Masato Tanaka, Yoshihiro Ito, Toshifumi Ozaki, Akihiro Matsukawa
The treatment of spinal cord injury (SCI) is currently a significant challenge. Hepatocyte growth factor (HGF) is a multipotent neurotrophic and neuroregenerative factor that can be beneficial for the treatment of SCI. However, immobilized HGF targeted to extracellular matrix may be more effective than diffusible, unmodified HGF. In this study, we evaluated the neurorestorative effects of an engineered HGF with a collagen biding domain (CBD-HGF). CBD-HGF remained in the spinal cord for 7 days after a single administration, while unmodified HGF was barely seen at 1 day...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343518/fibroblast-specific-%C3%AE-catenin-signaling-dictates-the-outcome-of-aki
#5
Dong Zhou, Haiyan Fu, Liangxiang Xiao, Hongyan Mo, Hui Zhuo, Xiaojun Tian, Lin Lin, Jianhua Xing, Youhua Liu
AKI is a devastating condition with high morbidity and mortality. The pathologic features of AKI are characterized by tubular injury, inflammation, and vascular impairment. Whether fibroblasts in the renal interstitium have a role in the pathogenesis of AKI is unknown. In this study, we investigated the role of fibroblast-specific β-catenin signaling in dictating the outcome of AKI, using conditional knockout mice in which β-catenin was specifically ablated in fibroblasts (Gli1-β-cat-/-). After ischemia-reperfusion injury (IRI), Gli1-β-cat-/- mice had lower serum creatinine levels and less morphologic injury than Gli1-β-cat+/+ littermate controls...
January 17, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29341114/recombinant-human-hepatocyte-growth-factor-provides-protective-effects-in-celurein-induced-acute-pancreatitis-in-mice
#6
Mayrel Palestino-Domínguez, Mario Pelaez-Luna, Roberto Lazzarini-Lechuga, Ignacio Rodríguez-Ochoa, Verónica Souza, Roxana U Miranda, Benjamín Pérez-Aguilar, Leticia Bucio, Jens U Marquardt, Luis Enrique Gomez-Quiroz, María Concepción Gutiérrez-Ruiz
Acute pancreatitis is a multifactorial disease associated with profound changes of the pancreas induced by release of digestive enzymes that lead to increase in proinflammatory cytokine production, excessive tissue necrosis, edema, and bleeding. Elevated levels of hepatocyte growth factor (HGF) and its receptor c-Met have been observed in different chronic and acute pancreatic diseases including experimental models of acute pancreatitis. In the present study, we investigated the protective effects induced by the recombinant human HGF in a mouse model of cerulein-induced acute pancreatitis...
January 17, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29337876/microenvironment-stimuli-hgf-and-hypoxia-differently-affected-mir-125b-and-ets-1-function-with-opposite-effects-on-the-invasiveness-of-bone-metastatic-cells-a-comparison-with-breast-carcinoma-cells
#7
Emanuela Matteucci, Paola Maroni, Francesco Nicassio, Francesco Ghini, Paola Bendinelli, Maria Alfonsina Desiderio
We examined the influence of microenvironment stimuli on molecular events relevant to the biological functions of 1833-bone metastatic clone and the parental MDA-MB231 cells. (i) In both the cell lines, hepatocyte growth factor (HGF) and the osteoblasts' biological products down regulated nuclear Ets-1-protein level in concomitance with endogenous miR-125b accumulation. In contrast, under hypoxia nuclear Ets-1 was unchanged, notwithstanding the miR-125b increase. (ii) Also, the 1833-cell invasiveness and the expression of Endothelin-1, the target gene of Ets-1/HIF-1, showed opposite patterns under HGF and hypoxia...
January 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29333721/carbohydrate-dose-influences-liver-and-muscle-glycogen-oxidation-and-performance-during-prolonged-exercise
#8
Andy J King, John P O'Hara, Douglas J Morrison, Tom Preston, Roderick F G J King
This study investigated the effect of carbohydrate (CHO) dose and composition on fuel selection during exercise, specifically exogenous and endogenous (liver and muscle) CHO oxidation. Ten trained males cycled in a double-blind randomized order on 5 occasions at 77% V˙O2max for 2 h, followed by a 30-min time-trial (TT) while ingesting either 60 g·h-1 (LG) or 75 g·h-113 C-glucose (HG), 90 g·h-1 (LGF) or 112.5 g·h-113 C-glucose-13 C-fructose ([2:1] HGF) or placebo. CHO doses met or exceed reported intestinal transporter saturation for glucose and fructose...
January 2018: Physiological Reports
https://www.readbyqxmd.com/read/29325232/expression-of-cd163-in-hereditary-gingival-fibromatosis-a-possible-association-with-tgf-%C3%AE-1
#9
Hala H Hazzaa, Ossama M Gouda, Naglaa M Kamal, Shereen Abdel Moula Ali, Marwa A M ElShiekh, Marwa M Tawfik
BACKGROUND: Although several studies have discussed some of the molecular and cellular changes associated with hereditary gingival fibromatosis (HGF), its pathogenesis is still largely unclear. This study was directed to detect and outline the degree of relationship between the immunophenotyped macrophages (M2) expressing CD163 and TGF-β1 in patients with gingival overgrowth due to HGF. METHODS: Biopsies from 20 patients suffering from HGF and 20 normal control subjects were harvested, histologically and immunohistochemically stained then, analyzed and statistically compared and correlated for CD163 immunoexpression and TGF-β1...
January 11, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29322249/mir-375-inhibits-the-hepatocyte-growth-factor-elicited-migration-of-mesenchymal-stem-cells-by-downregulating-akt-signaling
#10
Lihong He, Xianyao Wang, Naixin Kang, Jianwei Xu, Nan Dai, Xiaojing Xu, Huanxiang Zhang
The migration of mesenchymal stem cells (MSCs) is critical for their use in cell-based therapies. Accumulating evidence suggests that microRNAs are important regulators of MSC migration. Here, we report that the expression of miR-375 was downregulated in MSCs treated with hepatocyte growth factor (HGF), which strongly stimulates the migration of these cells. Overexpression of miR-375 decreased the transfilter migration and the migration velocity of MSCs triggered by HGF. In our efforts to determine the mechanism by which miR-375 affects MSC migration, we found that miR-375 significantly inhibited the activation of Akt by downregulating its phosphorylation at T308 and S473, but had no effect on the activity of mitogen-activated protein kinases...
January 10, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29321335/serum-hepatocyte-growth-factor-is-probably-associated-with-3-month-prognosis-of-acute-ischemic-stroke
#11
Zhengbao Zhu, Tan Xu, Daoxia Guo, Xinfeng Huangfu, Chongke Zhong, Jingyuan Yang, Aili Wang, Chung-Shiuan Chen, Yanbo Peng, Tian Xu, Jinchao Wang, Yingxian Sun, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Jing Chen, Yonghong Zhang, Jiang He
BACKGROUND AND PURPOSE: Serum hepatocyte growth factor (HGF) is positively associated with poor prognosis of heart failure and myocardial infarction, and it can also predict the risk of ischemic stroke in population. The goal of this study was to investigate the association between serum HGF and prognosis of ischemic stroke. METHODS: A total of 3027 acute ischemic stroke patients were included in this post hoc analysis of the CATIS (China Antihypertensive Trial in Acute Ischemic Stroke)...
January 10, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29320834/-the-role-and-mechanism-of-mesenchymal-stem-cell-in-modulating-human-pulmonary-microvascule-endothelial-cell-permeability-via-paracrine-hepatocyte-growth-factor
#12
Q H Chen, R Q Zheng, H L Wang, Y Yang, H B Qiu
Objective: To explore the role and mechanism of mesenchymal stem cell (MSC) in modulating human pulmonary microvascular endothelial cell (HPMECs) permeability via hepatocyte growth factor (HGF). Methods: The study introduced a co-cultured model between HPMECs and human mesenchymal stem cell conditioned media (MSC-CM) collected from MSCs after 24 h hypoxia culture, and meanwhile HGF was neutralized in MSC-CM by anti-HGF antibody respectively, followed by lipopolysaccharide (LPS) stimulation. Finally, the following measurements were performed: the permeability of HPMECs, the protein expression of vascular endothelial cadherin (VE-cadherin), Occludin in HPMECs by Western blot, HPMECs apoptosis by Annexin V-FITC/PI and HPMECs proliferation by 3-(4, 5)-dimethylthiahiazo (-z-y1)-3, 5-di- phenytetrazoliumromide(MTT)...
November 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29320421/comparative-analysis-of-different-platelet-lysates-and-platelet-rich-preparations-to-stimulate-tendon-cell-biology-an-in-vitro-study
#13
Franka Klatte-Schulz, Tanja Schmidt, Melanie Uckert, Sven Scheffler, Ulrich Kalus, Markus Rojewski, Hubert Schrezenmeier, Axel Pruss, Britt Wildemann
The poor healing potential of tendons is still a clinical problem, and the use of Platelet Rich Plasma (PRP) was hypothesized to stimulate healing. As the efficacy of PRPs remains unproven, platelet lysate (PL) could be an alternative with its main advantages of storage and characterization before use. Five different blood products were prepared from 16 male donors: human serum, two PRPs (Arthrex, (PRP-ACP); RegenLab (PRP-BCT)), platelet concentrate (apheresis, PC), and PL (freezing-thawing destruction of PC)...
January 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29315565/the-role-of-extracellular-matrix-metalloproteinase-inducer-glycosylation-in-regulating-matrix-metalloproteinases-in-periodontitis
#14
Z Zhang, X Yang, H Zhang, X Liu, S Pan, C Li
BACKGROUND AND OBJECTIVE: Extracellular matrix metalloproteinase inducer (EMMPRIN) is a transmembrane glycoprotein that may induce activation of matrix metalloproteinases (MMPs) and lead to the destruction of periodontal tissue. The level of EMMPRIN glycosylation might be involved in this process. This study aims to investigate the role of EMMPRIN glycosylation in regulating MMP-2 and MMP-9 during the progression of periodontitis. MATERIAL AND METHODS: Gingival tissues were collected from patients with chronic periodontitis and from patients undergoing crown-lengthening procedures (healthy gingival tissue)...
January 5, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29308696/early-pregnancy-protein-multiplex-screening-reflects-circulating-and-urinary-divergences-associated-with-the-development-of-preeclampsia
#15
Margarita L Martinez-Fierro, Claudia Castruita-De La Rosa, Idalia Garza-Veloz, Rosa M Cardiel-Hernandez, Marcela A Espinoza-Juarez, Ivan Delgado-Enciso, Maria E Castañeda-Lopez, Edith Cardenas-Vargas, Fabiola Trejo-Vázquez, Elma I Sotelo-Ham, Rodrigo Castañeda-Miranda, Miguel A Cid-Baez, Jose M Ortiz-Rodriguez, Luis O Solis-Sanchez, Angelica Garcia Aviles, Yolanda Ortiz-Castro
BACKGROUND: Preeclampsia, a pregnancy disorder characterized by hypertension and proteinuria, represents the leading cause of fetal and maternal morbidity and mortality in developing countries. The identification of novel and accurate biomarkers that are predictive of preeclampsia is necessary to improve the prognosis of patients with preeclampsia. OBJECTIVE: To evaluate the preeclampsia predictive value of 34 angiogenic-related proteins. METHODS: We performed a nested cohort case-control study of pregnant women...
January 8, 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29306486/modulation-of-gingival-cell-response-towards-dental-composites
#16
A Jerg, S D Schulz, P Tomakidi, E Hellwig, O Polydorou
OBJECTIVE: This aim of this study was to investigate the cell behavioural response on clinically applied dental composites in exposition-relevant target cells, i.e. human gingival fibroblasts (HGF) and epithelial keratinocytes (HGK). METHODS: HGF and HGK were exposed to eluates of Ceram X™, Filtek™ Silorane, Filtek™ Supreme XTE, Fusio™ Liquid Dentin and Vertise™ Flow. Eluates were created by storing material samples in respective cell culture medium, for 24h and 72h (n=17), according to ISO 10993-12:2012...
January 3, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29296725/replenishing-exosomes-from-older-bone-marrow-stromal-cells-with-mir-340-inhibits-myeloma-related-angiogenesis
#17
Tomohiro Umezu, Satoshi Imanishi, Kenko Azuma, Chiaki Kobayashi, Seiichiro Yoshizawa, Kazuma Ohyashiki, Junko H Ohyashiki
The study of bone marrow stromal cells (BMSCs) and the exosomes they secrete is considered promising for cancer therapy. However, little is known about the effect of donor age on BMSCs. In the present study, we investigated the therapeutic potential of BMSC exosomes derived from donors of different ages using an in vivo model of hypoxic bone marrow in multiple myeloma (MM). We found that donor age was strongly related to senescent changes in BMSCs. Exosomes derived from young BMSCs significantly inhibited MM-induced angiogenesis in Matrigel plugs...
May 23, 2017: Blood Advances
https://www.readbyqxmd.com/read/29296173/extracellular-superoxide-dismutase-inhibits-hepatocyte-growth-factor-mediated-breast-cancer-fibroblast-interactions
#18
Briana Ormsbee Golden, Brandon Griess, Shakeel Mir, Matthew Fitzgerald, Charlotte Kuperwasser, Frederick Domann, Melissa Teoh-Fitzgerald
We have previously shown tumor suppressive effects of extracellular superoxide dismutase, EcSOD in breast cancer cells. In this study, an RTK signaling array revealed an inhibitory effect of EcSOD on c-Met phosphorylation and its downstream kinase c-Abl in MDA-MB231 cells. Moreover, an extracellular protein array showed that thrombospondin 1 (TSP-1), a scavenger of the c-Met ligand, hepatocyte growth factor (HGF) is significantly up-regulated in EcSOD overexpressing cells (Ec.20). We further determined the effects of EcSOD on HGF/c-Met-mediated cancer-fibroblast interactions by co-culturing normal fibroblasts (RMF) or RMF which overexpresses HGF (RMF-HGF) with MDA-MB231 cells...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29285843/exosomes-serve-as-nano-particles-to-suppress-tumor-growth-and-angiogenesis-in-gastric-cancer-by-delivering-hgf-sirna
#19
Haiyang Zhang, Yi Wang, Ming Bai, Junyi Wang, Kegan Zhu, Rui Liu, Shaohua Ge, JiaLu Li, Tao Ning, Ting Deng, Qian Fan, Hongli Li, Wu Sun, Guoguang Ying, Yi Ba
Exosomes derived from cells have been found to mediate signal transduction between cells and to act as efficient carriers to deliver drugs and small RNAs. HGF is known to promote the growth of both cancer cells and vascular cells, and the HGF-cMET pathway is a potential clinical target. Here, we characterized the inhibitory effect of HGF siRNA on tumor growth and angiogenesis in gastric cancer. In addition, we showed that HGF siRNA packed in exosomes can be transported into cancer cells, where it dramatically down-regulates HGF expression...
December 29, 2017: Cancer Science
https://www.readbyqxmd.com/read/29284215/clinical-assessment-after-human-adipose-stem-cell-transplantation-in-dogs
#20
Seok Hee Lee, Erif Maha Nugraha Setyawan, Yoo Bin Choi, Jeong Chan Ra, Sung Keun Kang, Geon A Kim, Byeong Chun Lee
Adipose stem cells (ASCs) are an attractive source of stem cells with therapeutic applicability in various fields for regenerating damaged tissues because they show stemness characteristics. However, little investigation has been done to evaluate adverse responses caused by human ASCs therapy. Therefore, in the present study, a clinical assessment after human ASCs transplantation in dogs was investigated. A total of 12 healthy male dogs were selected and divided into 4 groups: 1) saline infusion and bolus groups, and 2) ASCs infusion and bolus groups...
December 28, 2017: Journal of Veterinary Science
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