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https://www.readbyqxmd.com/read/28522754/met-exon-14-mutation-encodes-an-actionable-therapeutic-target-in-lung-adenocarcinoma
#1
Xinyuan Lu, Nir Peled, John Greer, Wei Wu, Peter Choi, Alice H Berger, Sergio Wong, Kuang-Yu Jen, Youngho Seo, Byron Hann, Angela Brooks, Matthew Meyerson, Eric A Collisson
Targeting somatically activated oncogenes has revolutionized the treatment of non-small cell lung cancer (NSCLC). Mutations in the gene mesenchymal-epithelial transition (MET) near the exon 14 splice sites are recurrent in lung adenocarcinoma and cause exon skipping (METΔ14). Here we analyzed 4,422 samples from 12 different malignancies to estimate the rate of said exon skipping. METΔ14 mutation and transcript were most common in lung adenocarcinoma. Endogenously expressed levels of METΔ14 transformed human epithelial lung cells in a Hepatocyte growth factor (HGF)-dependent manner...
May 18, 2017: Cancer Research
https://www.readbyqxmd.com/read/28518180/the-effects-of-laser-with-different-parameters-and-crosshatching-on-fibroblast-adhesion-and-proliferation-to-implant-surfaces
#2
Hakki Çelebi, Pembegül Uyar Arpacı, Ilhami Çelik, Serhan Akman
PURPOSE: To compare the adhesion and proliferation effect of HGF-1 cells on pure titanium disks when the surfaces are unprocessed (machined surfaces after slicing) or modified with a laser. MATERIALS AND METHODS: Twenty-eight titanium disks were divided into four groups. Three surface topographies were created using an erbium fiber laser: group 1 (unidirectional application [no crosshatch]), group 2 (crosshatching in two directions), and group 3 (crosshatching in three directions)...
May 18, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28514740/differential-expression-of-circulating-biomarkers-of-tumor-phenotype-and-outcomes-in-previously-treated-non-small-cell-lung-cancer-patients-receiving-erlotinib-vs-cytotoxic-chemotherapy
#3
Mary Jo Fidler, Casey Frankenberger, Richard Seto, Gabriela C Lobato, Cristina L Fhied, Selina Sayidine, Sanjib Basu, Mark Pool, Reem Karmali, Marta Batus, Wen-Rong Lie, David Hayes, Jehangir Mistry, Philip Bonomi, Jeffrey A Borgia
BACKGROUND: The objective of this study was to identify serum biomarkers capable of predicting clinical outcomes in previously-treated NSCLC patients with wild-type for EGFR activating mutations or insufficient tissue for mutation status determination. METHODS: Sixty-six Luminex immunoassays representative of biological themes that emerged from a re-analysis of transcriptome data from the Cancer Genome Atlas (TCGA) were evaluate against pretreatment serum specimens from previously-treated advanced NSCLC patients received either cytotoxic chemotherapy (n=32) or erlotinib (n=79)...
April 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28512644/analysis-of-serum-cytokines-and-single-nucleotide-polymorphisms-of-sod1-sod2-and-cat-in-erysipelas-patients
#4
Charles C Emene, Irina E Kravchenko, Gulnaz I Aibatova, Albert A Rizvanov
Increased free radical production had been documented in group A (β-hemolytic) streptococcus infection cases. Comparing 71 erysipelas patients to 55 age-matched healthy individuals, we sought for CAT, SOD1, and SOD2 single polymorphism mutation (SNPs) interactions with erysipelas' predisposition and serum cytokine levels in the acute and recovery phases of erysipelas infection. Whereas female patients had a higher predisposition to erysipelas, male patients were prone to having a facial localization of the infection...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28512490/in-vitro-cytotoxicity-of-a-new-nano-root-canal-sealer-on-human-gingival-fibroblasts
#5
Maryam Javidi, Parisa Dastmalchi, Mina Zarei, Maryam Shayani Rad, Ahmad Ghorbani
INTRODUCTION: The aim of this in vitro study was to evaluate the cytotoxicity of a new nano zinc-oxide eugenol (NZOE) sealer on human gingival fibroblasts (HGFs) compared with Pulpdent (micro-sized ZOE sealer) and AH-26 (resin-based sealer). METHODS AND MATERIALS: The Pulpdent, AH-26, and NZOE sealers were prepared and exposed to cell culture media immediately after setting, and 24 h and one week after setting. Then, the primary cultured HGFs were incubated for 24 h with different dilutions (1:1 to 1:32) of each sealer extract...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28504963/novel-pleiotropic-effects-of-bioactive-phospholipids-in-human-lung-cancer-metastasis
#6
Gabriela Schneider, Zachariah Payne Sellers, Kamila Bujko, Sham S Kakar, Magda Kucia, Mariusz Z Ratajczak
We previously proposed that one of the unwanted side effects of chemotherapy and radiotherapy is the increase in several peptide- and non-peptide based chemoattractants in damaged tissues, leading to induction of a prometastatic microenvironment for remaining cancer cells. Herein, we turned out our attention to a potential role of bioactive phospholipids (BphsLs), such as sphingosine-1-phosphate (S1P), ceramide-1-phosphate (C1P), lysophosphatidylcholine (LPC), and lysophosphatidic acid (LPA) in lung cancer (LC) metastasis...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28502469/hepatocyte-growth-factor-suppresses-inflammation-and-promotes-epithelium-repair-in-corneal-injury
#7
Masahiro Omoto, Kunal Suri, Afsaneh Amouzegar, Mingshun Li, Kishore R Katikireddy, Sharad K Mittal, Sunil K Chauhan
Corneal injuries are among the major causes of ocular morbidity and vision impairment. Optimal epithelial wound healing is critical for the integrity and transparency of the cornea after injury. Hepatocyte growth factor (HGF) is a mitogen and motility factor that primarily regulates epithelial cell function. Herein, we investigate the effect of HGF on proliferation of corneal epithelial cells (CECs) in inflamed conditions both in vitro and in vivo. We demonstrate that HGF not only promotes CEC proliferation in homeostatic conditions but also reverses the anti-proliferative effect of the inflammatory environment on these cells...
May 10, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28498406/crizotinib-a-met-inhibitor-prevents-peritoneal-dissemination-in-pancreatic-cancer
#8
Soichi Takiguchi, Kazuko Inoue, Kimihiko Matsusue, Masayuki Furukawa, Norihiro Teramoto, Haruo Iguchi
Peritoneal dissemination is a frequent occurrence in pancreatic cancer, which is associated with a poor prognosis. MET is associated with the progression of pancreatic cancer; therefore, we evaluated the effect of a MET inhibitor, crizotinib, on peritoneal dissemination of pancreatic cancer. Crizotinib inhibited the growth of 8 pancreatic cancer cell lines with the IC50 ranging from 1.4 to 4.3 µM. Invasion of the pancreatic cancer cell line Suit-2, was suppressed in vitro at a concentration of 1.0 µM, which is sufficient for the inhibition of MET phosphorylation...
May 11, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28497393/effect-of-miscanthus-sinensis-var-purpurascens-flower-extract-on-proliferation-and-molecular-regulation-in-human-dermal-papilla-cells-and-stressed-c57bl-6-mice
#9
GiHee Jeong, William A Boisvert, Mei-Zhu Xi, Yi-Lin Zhang, Young-Bin Choi, Sunghun Cho, Sanghyun Lee, Changsun Choi, Bog-Hieu Lee
OBJECTIVES: To investigate the hair growth-promoting effect of Miscanthus sinensis var. purpurascens (MSP) flower extracton on in vitro and in vivo models. METHODS: MSP flower extract was extracted in 99.9% methanol and applied to examine the proliferation of human dermal papilla cells (hDPCs) in vitro at the dose of 3.92-62.50 μg/mL and hair growth of C57BL/6 mice in vivo at the dose of 1000 μg/mL. The expression of transforming growth factor β1 (TGF-β1), hepatocyte growth factor (HGF), β-catenin, substance P was measured by relative quantitative realtime polymerase chain reaction...
May 11, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28486560/analysis-of-aqueous-humor-concentrations-of-cytokines-in-retinoblastoma
#10
Yong Cheng, Shufeng Zheng, Chung-Ting Pan, Mengke Yuan, Libin Chang, Yuou Yao, Mingwei Zhao, Jianhong Liang
To investigate the components of the aqueous humor (AH) in patients with retinoblastoma (RB). We collected 0.1 ml AH of 35 children with RB and 20 patients with congenital cataracts as controls. Multiplex enzyme-linked immunosorbent assays (ELISAs) and Luminex xMAP technology were used to assess 45 cytokines/chemokines, matrix metalloproteinases (MMPs), and acute-phase proteins in the identification cohort. The concentrations of IL-6, IL-7, IL-8, IFN-γ, PIGF-1, VEGF-A, β-NGF, HGF, EGF and FGF-2 were significantly higher in the AH of patients with RB than those in the control group (P<0...
2017: PloS One
https://www.readbyqxmd.com/read/28485480/shikonin-inhibited-migration-and-invasion-of-human-lung-cancer-cells-via-suppression-of-c-met-mediated-epithelial-to-mesenchymal-transition
#11
Yei-San Hsieh, Chiung-Ho Liao, Wan-Shen Chen, Jih-Tung Pai, Meng-Shih Weng
Epithelial-to-mesenchymal transition (EMT) is a major process to regulate cell migration and invasion. Inhibition of epidermal growth factor receptor (EGFR)-mediated EMT by tyrosine kinase inhibitors (TKIs) is a strategy to prevent lung cancer invasion. However, drug resistance is emerged and accelerated invasion through other signaling bypassing EGFR after TKIs therapy. c-Met signaling pathway is highly activated in EGFR-mutated lung cancer cells. Targeting c-Met signaling pathway may be a strategy to suppress EGFR-independent migration and invasion for lung cancer therapy...
May 9, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28482601/functionalized-biocompatible-and-impermeable-nanoscale-coatings-for-peek
#12
Firas Awaja, Pieter Cools, Birgit Lohberger, Anton Yu Nikiforov, Giorgio Speranza, Rino Morent
Biologically compatible coatings that provide hermetic seal could resolve a major technological hurdle in the attempt to replace metals with polymers for biochips and active medical implants. The use of amorphous carbon/diamond like carbon (a-C:H) coatings to hermetically seal and biologically enhance polyether-ether-ketone (PEEK) for biomedical device integration in the human body was investigated. The PEEK coating functionality (sp3/sp2 ratio), hardness and thickness (70-200nm) were controlled, by varying H2 and N2 concentration during the plasma operation with CH4...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28476816/diagnostic-performance-of-a-novel-multiplex-immunoassay-in-colorectal-cancer
#13
Katja Dressen, Natalie Hermann, Steffen Manekeller, Gisela Walgenbach-Bruenagel, Frank A Schildberg, Karina Hettwer, Steffen Uhlig, Jörg C Kalff, Gunther Hartmann, Stefan Holdenrieder
BACKGROUND/AIM: We evaluated the diagnostic performance of a newly-launched magnetic bead-based multiplex immunoassay panel including cancer, apoptotic, immunological and angiogenesis biomarkers for differential diagnosis of colorectal cancer (CRC). PATIENTS AND METHODS: Serum samples of 106 individuals comprising of 35 patients with CRC (23 colon cancer, 12 rectal cancer), 20 with respective benign colorectal diseases and 51 healthy controls were analyzed by the Milliplex™ MAP Human Circulating Cancer Biomarker Panel 1 run on the Bio-Plex™ 200 System...
May 2017: Anticancer Research
https://www.readbyqxmd.com/read/28476806/fibronectin-and-hepatocyte-growth-factor-produced-by-lung-fibroblasts-augment-migration-and-invasion-of-malignant-pleural-mesothelioma-cells
#14
Nobuhiro Kanaji, Nobuyuki Kita, Norimitsu Kadowaki, Shuji Bandoh
BACKGROUND: The interaction between fibroblasts and malignant pleural mesothelioma (MPM) cells is not well understood. MATERIALS AND METHODS: Lung fibroblasts (HFL1, MRC5 and IMR90) and MPM cells (H28, H226 and H2052) were cultured under serum-free conditions and the resulting culture media were collected. Migration and invasion of MPM cells were assessed by chemotaxis and Matrigel assays, respectively. RESULTS: Lung fibroblast-derived media enhanced the migration and invasion of the three tested MPM cell lines...
May 2017: Anticancer Research
https://www.readbyqxmd.com/read/28475121/hgf-met-signaling-in-cancer-invasion-the-impact-on-cytoskeleton-remodeling
#15
REVIEW
Chuan Xiang, Junxia Chen, Panfeng Fu
The invasion of cancer cells into surrounding tissue and the vasculature is essential for tumor metastasis. Increasing evidence indicates that hepatocyte growth factor (HGF) induces cancer cell migration and invasion. A broad spectrum of mechanisms underlies cancer cell migration and invasion. Cytoskeletal reorganization is of central importance in the development of the phenotype of cancer cells with invasive behavior. Through their roles in cell mechanics, intracellular trafficking, and signaling, cytoskeleton proteins participate in all essential events leading to cell migration...
May 5, 2017: Cancers
https://www.readbyqxmd.com/read/28474864/the-impact-of-met-inhibition-on-small-cell-lung-cancer-cells-exhibiting-aberrant-activation-of-the-hgf-met-pathway
#16
Hirokazu Taniguchi, Tadaaki Yamada, Shinji Takeuchi, Sachiko Arai, Koji Fukuda, Shuichi Sakamoto, Manabu Kawada, Hiroyuki Yamaguchi, Hiroshi Mukae, Seiji Yano
Small-cell lung cancer (SCLC) accounts for approximately 15% of all lung cancers, and is characterized as being extremely aggressive, often displaying rapid tumor growth and multiple organ metastases. In addition, the clinical outcome of SCLC patients is poor due to early relapse and acquired resistance to standard chemotherapy treatments. Hence, novel therapeutic strategies for the treatment of SCLC are urgently required. Accordingly, several molecular targeted therapies were evaluated in SCLC; however, they failed to improve the clinical outcome...
May 5, 2017: Cancer Science
https://www.readbyqxmd.com/read/28472537/phase-1-2-study-of-rilotumumab-amg-102-a-hepatocyte-growth-factor-inhibitor-and-erlotinib-in-patients-with-advanced-non-small-cell-lung-cancer
#17
Ahmad A Tarhini, Imran Rafique, Theofanis Floros, Phu Tran, William E Gooding, Liza C Villaruz, Timothy F Burns, David M Friedland, Daniel P Petro, Mariya Farooqui, Jose Gomez-Garcia, Autumn Gaither-Davis, Sanja Dacic, Athanassios Argiris, Mark A Socinski, Laura P Stabile, Jill M Siegfried
BACKGROUND: Activation of the mesenchymal-epidermal transition factor (MET) tyrosine kinase and its ligand, hepatocyte growth factor (HGF), is implicated in resistance to epidermal growth factor receptor (EGFR) inhibitors. In this phase 1/2 trial, rilotumumab (an anti-HGF antibody) combined with erlotinib was evaluated in patients with metastatic, previously treated non-small cell lung cancer. METHODS: In phase 1, a dose de-escalation design was adopted with rilotumumab starting at 15 mg/kg intravenously every 3 weeks and oral erlotinib 150 mg daily...
May 4, 2017: Cancer
https://www.readbyqxmd.com/read/28472534/the-persistent-promise-of-combining-hgf-met-and-egfr-inhibition-in-non-small-cell-lung-cancer
#18
EDITORIAL
Jody C Chuang, Joel W Neal
No abstract text is available yet for this article.
May 4, 2017: Cancer
https://www.readbyqxmd.com/read/28471327/renal-regenerative-potential-of-different-extra-cellular-vesicle-populations-derived-from-bone-marrow-mesenchymal-stromal-cells
#19
Stefania Bruno, Marta Tapparo, Federica Collino, Giulia Chiabotto, Maria Chiara Deregibus, Rafael Soares Lindoso, Francesco Neri, Sharad Kholia, Sara Giunti, Sicheng Wen, Peter Quesenberry, Giovanni Camussi
Extra-cellular vesicles (EVs) derived from human bone marrow mesenchymal stromal cells (MSCs) promote the regeneration of kidneys in different animal models of AKI in a manner comparable to the cells of origin. However, due to the heterogeneity observed in the EVs isolated from MSC, it is unclear which population is responsible for the pro-regenerative effects. We therefore evaluated the effect of various EV-populations separated by differential ultracentrifugation (10K population enriched with microvesicles and 100K population enriched with exosomes) on AKI recovery...
May 4, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28470386/human-gingival-fibroblast-response-to-enamel-matrix-derivative-porcine-recombinant-21-3-kda-amelogenin-and-5-3-kda-tyrosine-rich-amelogenin-peptide
#20
Marzena Wyganowska-Swiatkowska, Paulina Urbaniak, Daniel Lipinski, Marlena Szalata, Malgorzata Kotwicka
Enamel matrix derivative (EMD) containing a variety of protein fractions has been used for periodontal tissue regeneration. It is suggested that the proteins contained in EMD positively influence gingival fibroblasts migration and proliferation. Effects of EMD as well as of porcine recombinated 21.3-kDa amelogenin (prAMEL) and 5.3-kDa tyrosine-rich amelogenin peptide (prTRAP) on human gingival fibroblast (HGF-1, ATCC; USA) cell line were investigated. Real-time cell analysis (xCELLigence system; Roche Applied Science) was performed to determine the effects of EMD, prAMEL and prTRAP (12...
May 3, 2017: Human Cell
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