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S Attafi, N Boujelbene, I Abbes, R Doghri, N Ben Hamida, R Ghorbel, L Charfi, M Driss, K Mrad
Vaginal rhabdomyoma is an extremely rare tumor which presents as a vaginal polypoid masses. It is essential to differentiate it from benign and malignant mimickers so that appropriate therapy may be provided. The present report describes a vaginal wall nodule of a symptomatic 24-year-old woman. Local excision and subsequent pathological examination were performed. The final diagnosis was vaginal rhabdomyoma. The literature is reviewed and differential diagnosis are discussed.
December 2017: Pathologica
S M Balaji
Background: Nasal deformity in bilateral cleft lip and palate (BCLP) correction is highly challenging. Several solution has been proposed. The aim of the present study is to assess qualitatively and quantitatively the results of Cronin's flap, Fork flap, and Abbe's flap for BCLP rhinoplasty at a follow-up period. Materials and Methods: : Records of all BCLP rhinoplasty performed between 2010 and 2016, fulfilling inclusion and exclusion criteria were collected. From records, qualitative improvement and previously described methods of quantification of columella length were performed...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
Marie Abbes, Eugénie Lhommée, Stéphane Thobois, Hélène Klinger, Emmanuelle Schmitt, Amélie Bichon, Anna Castrioto, Jing Xie, Valérie Fraix, Andrea Kistner, Pierre Pélissier, Éric Seigneuret, Stéphan Chabardès, Patrick Mertens, Emmanuel Broussolle, Elena Moro, Paul Krack
BACKGROUND: Reports on behavioural outcomes after subthalamic nucleus deep brain stimulation in Parkinson's disease are controversial and limited to short-term data. Long-term observation in a large cohort allows a better counselling and management. METHODS: To determine whether a long-term treatment with subthalamic stimulation induces or reduces impulse control behaviours, neuropsychiatric fluctuations and apathy, 69 patients treated with subthalamic stimulation are prospectively and retrospectively assessed using Ardouin Scale of Behavior in Parkinson's Disease before and after 3-10 years of stimulation...
February 7, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Mary Kathryn Cancilliere, Jennifer Freeman, Abbe Garcia, Kristen Benito, Jeffrey Sapyta, Martin Franklin
Obsessive-compulsive disorder (OCD) in children under 8 years of age, referred to as early-onset OCD, has similar features to OCD in older children, including moderate to severe symptoms, impairment, and significant comorbidity. Family-based cognitive behavioral therapy (FB-CBT) has been found efficacious in reducing OCD symptoms and functional impairment in children ages 5-8 years with OCD; however, its effectiveness on reducing comorbid psychiatric symptoms in this same population has yet to be demonstrated...
February 13, 2018: Child Psychiatry and Human Development
Da-Hui Qu, Si-Jia Rao, Qi Zhang, Xu-Hao Ye, Chuan Gao
The structural complexity of mechanically interlocked molecules have been greatly attractive chemist to challenging. In this article, a novel mechanically interlocked molecules daisy-chain-containing hetero[4]rotaxane was efficiently synthesized. In the meantime, a novel integrative self-sorting strategy is demonstrated involving an ABB-type (A for host, dibenzo-24-crown-8 (DB24C8), and B for guest, ammonium salt sites) monomer and the other macrocycle host, benzo-21-crown-7 (B21C7), in which the assembled species in hydrogen-bonding-supported solvent only includes a novel daisy-chain-containing hetero[4]pseudorotaxane...
February 9, 2018: Chemistry, An Asian Journal
Abbe Haser, Tu Cao, Joseph W Lubach, Feng Zhang
As the pipeline for poorly soluble compounds continues to grow, drug degradation during melt extrusion must be addressed. We present a novel method for stabilizing a thermally labile drug substance while preserving its physical stability and even improving its dissolution performance. In a previous study, we found that incorporating meglumine during extrusion of meloxicam results in chemical stabilization that cannot be achieved using process optimization alone. The purpose of this study is to understand the mechanism behind this stabilization and its impact on the performance of a meloxicam-copovidone amorphous solid dispersion...
February 7, 2018: Molecular Pharmaceutics
Soo-Ha Kwon, Che-Hsiung Lee, Angela Ting-Wei Hsu, Mark Shafarenko, Usama Farghaly Omar, Chieh-Han John Tzou, Julia Roka-Palkovits, Aldo G Beltrán P, Dimitri Liakos, Tommy Nai-Jen Chang
BACKGROUND:  The best reconstructive strategy for upper lip defects is still in debate. The purpose of this study was to analyze the decisions made by international microsurgeons, who were participated through online questionnaire, distributed by email and social media network. MATERIALS AND METHODS:  A case of a two-thirds upper lip oncologic defect was presented via an online questionnaire and 402 microsurgeons replied their treatment options. The data were then analyzed according to the geographic area, microsurgical fellowship, seniority, and subspecialty...
February 2, 2018: Journal of Reconstructive Microsurgery
Shoumin Zhu, Zheng Chen, Lihong Wang, DunFa Peng, Abbes Belkhiri, Albert Craig Lockhart, Wael El-Rifai
PURPOSE: We aimed to investigate the therapeutic efficacy of single agent and the combination of quinacrine (QC) and suberoylanilide hydroxamic acid (SAHA) in wt- and mut-p53 upper gastrointestinal cancer (UGC) cell models. EXPERIMENTAL DESIGN: ATP-Glo, clonogenic survival, Annexin V, comet, DNA double-strand breaks (DSB), quantitative real-time PCR (qPCR), and Western blot analysis assays were utilized. RESULTS: Using clonogenic cell survival, ATP-Glo cell viability, Annexin V, and sub-G0 population analysis, we demonstrate that a combination of QC and SAHA significantly decreased colony formation and increased cancer cell death (range: 4 - 20 fold) in 6 UGC cell models, as compared to single agent treatments, irrespective of the p53 status (P < 0...
January 31, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Andre Portz, Markus Baur, Gordon Rinke, Sabine Abb, Stephan Rauschenbach, Klaus Kern, Michael Dürr
Desorption/Ionization induced by Neutral SO2 Clusters (DINeC) is used for mass spectrometry (MS) of surface-adsorbed molecules. The method is shown to be a surface sensitive analysis tool capable to detect molecular adsorbates in a wide range of molecular weight as well as their reactions on surfaces, which are otherwise difficult to be accessed. Two different surface/adsorbate systems prepared by means of electrospray ion beam deposition were investigated: For the peptide angiotensin II on gold, intact molecules were desorbed from the surface when deposited by soft landing electrospray ion beam deposition (ES-IBD)...
January 27, 2018: Analytical Chemistry
Zaied Sonia, Daldoul Amira, Bhiri Hanene, Ammar Nouha, Khechine Wiem, Toumi Omar, Abbes Ibtissem, Ben Salem Amina, Njima Manel, Mhabrech Houda
Squamous cell carcinoma (SCC) of the rectum is a rare disease. A 59-year-old man presented with SCC of the middle rectum located 10 cm from the anus. The stage of the tumor was revealed to be T3N+M0. The patient received a combined treatment with cisplatin and fluorouracil in concomitance with external radiation therapy. He then underwent an anterior resection of the rectum. The postoperative histopathological findings classified the tumor as ypT0N0 with cancer-free margins and lymph nodes. Treatment of SCC remains very challenging, and the acquisition of more consistent data is needed...
November 2017: Cancer Biology & Medicine
Jelle van Wesemael, Yann Hueber, Ewaut Kissel, Nádia Campos, Rony Swennen, Sebastien Carpentier
The fate of doubled genes, from allopolyploid or autopolyploid origin, is controlled at multiple levels, resulting in the modern day cultivars. We studied the root growth of 3 different triploid banana cultivars under control and osmotic stress conditions. The root growth of the allopolyploid ABB cultivar was 42% higher under control and 61% higher under osmotic stress. By integrating transcriptomics and proteomics, we studied the gene expression of all 3 cultivars, resulting in 2,749 identified root proteins...
January 22, 2018: Scientific Reports
Tae Ho Kim, Doug Hyun Han, Seo Koo Yoo, Jung Jae Lee, Ji Eun Kim, Un Sun Chung
BACKGROUND: We aimed to verify a Korean version of the Abbreviated University of California, Los Angeles, Post-Traumatic Stress Disorder Reaction Index (Abb-UCLA-PTSD RI-Korean version) among Korean adolescents to assess post-traumatic stress in this population. METHODS: We recruited 1,254 adolescents who completed the Abb-UCLA-PTSD RI-Korean version scale, the Child Report of Post-Traumatic Symptoms (CROPS), the Lifetime Incidence of Traumatic Events (LITE), and the Children's Depression Inventory (CDI)...
January 29, 2018: Journal of Korean Medical Science
Abbe Haser, Feng Zhang
The understanding of amorphous solid dispersions has grown significantly in the past decade. This is evident from the number of approved commercial amorphous solid dispersion products. While amorphous formulation is considered an enabling technology, it has become the norm for formulating poorly soluble compounds. Despite this success, improvements can still be made that enable early development formulation decisions, to develop a rationale for selecting a manufacturing process, to overcome degradation and phase separation during processing, to help achieve physical stability during storage, and to optimize dissolution behavior...
January 16, 2018: AAPS PharmSciTech
K Schon, E Rytina, J Drummond, J Simmonds, S Abbs, R Sandford, M Tischkowitz
BACKGROUND: Muir-Torre syndrome (MTS) is a subtype of Lynch syndrome, which encompasses the combination of sebaceous skin tumours or keratoacanthomas and internal malignancy, due to mutations in DNA mismatch repair genes. Sebaceous neoplasms (SNs) may occur before other malignancies, and may lead to the diagnosis, which allows testing of other family members, cancer surveillance, risk-reducing surgery or prevention therapies. AIM: To evaluate the efficacy of universal immunohistochemistry (IHC) screening of SNs in a service setting...
January 14, 2018: Clinical and Experimental Dermatology
Abbe Harper Crawford, Rodolfo Cappello, Akash Alexander, Steven De Decker
OBJECTIVE:  This case series describes the clinical presentation, management and outcome of three cats diagnosed with cervical intervertebral disc disease that underwent decompressive ventral slot surgery. METHODS:  This is a retrospective case series evaluating client-owned cats undergoing a ventral slot surgical procedure to manage cervical intervertebral disc disease (n = 3). RESULTS:  A routine ventral slot surgery was performed in each case without complication, resulting in postoperative neurological improvement in all three cases...
January 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Emily A Oliver, Mark Klebanoff, Lina Yossef-Salameh, Reena Oza-Frank, Soheil Moosavinasab, Patricia Reagan, Louis Muglia, Catalin S Buhimschi, Irina A Buhimschi
OBJECTIVE: To compare preterm birth rates and gestational length in four race-nativity groups including Somali Americans. METHODS: Using a retrospective cohort study design of Ohio birth certificates, we analyzed all singleton births between 2000 and 2015 from four groups of women categorized as U.S.-born, non-Hispanic white (USBW), U.S.-born, non-Hispanic black (USBB), African-born black (ABB, primarily of West African birth country), and Somalia-born (SB). An algorithm trained on maternal names was used to confirm Somali ethnicity...
January 9, 2018: Obstetrics and Gynecology
Elizabeth S Abbs, Maebe Brown, Melissa Lemke, Lauren Bauer, Steve Ohly, Cynthia Haq
Latina women living in low-income communities frequently report a high prevalence of feeling physically and/or emotionally "unwell." Formative focus groups were used to design a 3-session stress reduction curriculum called ¡Venga y Relájese! (Come and relax yourself!). Survey data from 5 Milwaukee cohorts and 1 Peruvian cohort revealed statistically significant improvements in general health status, perceived stress status, and confidence to manage future stress among women who completed all sessions (n=54)...
August 2017: WMJ: Official Publication of the State Medical Society of Wisconsin
Hyun-Suk Kim, Ju-Cheol Park, Pil-Young Yun, Young-Kyun Kim
Background: The goal of this study is to evaluate complication and effectiveness of alveolar ridge augmentations using a hydroxyapatite-based alloplastic bony substitute with rhBMP-2. Methods: A total of 10 patients (4 males, 6 females; 58.5 ± 8.6 years) participated in this clinical research. Alveolar ridge augmentations were performed in edentulous (4 maxillary posterior, 5 mandibular posterior, and 1 mandibular anterior) regions. Anorganic bovine bone (ABB; Bio-Oss®, Geistlich Pharma AG, Wolhusen, Switzerland) was used as the bone graft material in the control group (n = 5)) while hydroxyapatite-based alloplastic bony substitute with rhBMP-2(HA+rhBMP-2; NOVOSIS®-Dent, CGBio Inc...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
Irina Y Yanina, Alexey P Popov, Alexander V Bykov, Igor V Meglinski, Valery V Tuchin
Observation of temperature-mediated phase transitions between lipid components of the adipose tissues has been performed by combined use of the Abbe refractometry and optical coherence tomography. The phase transitions of the lipid components were clearly observed in the range of temperatures from 24°C to 60°C, and assessed by quantitatively monitoring the changes of the refractive index of 1- to 2-mm-thick porcine fat tissue slices. The developed approach has a great potential as an alternative method for obtaining accurate information on the processes occurring during thermal lipolysis...
January 2018: Journal of Biomedical Optics
F J Gilbert, A Selamoglu
Screening with mammography has been implemented in many countries across the world with most offering 2-yearly examinations between the ages of 50-69 years. Robust modelling tools that include breast density and single nucleotide polymorphisms (SNPs) have been developed to predict which women are most likely to develop breast cancer. Mammographic sensitivity is poor in women with the densest category of breast tissue, and even women with heterogeneously dense tissue may benefit from additional supplemental imaging...
December 19, 2017: Clinical Radiology
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