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M Orsucci, P Audiot, S Nidelet, F Dorkeld, A Pommier, M Vabre, D Severac, M Rohmer, B Gschloessl, R Streiff
BACKGROUND: Divergent selection has been shown to promote speciation in many taxa and especially in phytophagous insects. In the Ostrinia species complex, the European corn borer (ECB) and adzuki bean borer (ABB) are two sibling species specialized to different host plants. The first is a well-known maize pest, whereas the second is a polyphagous species associated with various dicotyledons. Their specialization to host plants is driven by morphological, behavioral and physiological adaptations...
September 20, 2018: BMC Evolutionary Biology
Ilaria Sabatucci, Innocenza Palaia, Cinzia Marchese, Ludovico Muzii, Chiara Della Morte, Margherita Giorgini, Angela Musella, Simona Ceccarelli, Enrica Vescarelli, Pierluigi Benedetti Panici
OBJECTIVE: Evaluating sexual function and quality of life (QoL) in patients treated with a modified Abbé-McIndoe technique using in vitro cultured autologous vaginal mucosa. DESIGN: Descriptive study. SETTING: Policlinico Umberto I, "Sapienza" University of Rome. POPULATION: From 2006 to 2016, 39 women affected by Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) underwent vaginoplasty at our center using a modified Abbé-McIndoe technique with in vitro cultured autologous vaginal tissue...
September 19, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Jihène Ben Thabet, Manel Mâalej, Hana Khemakhem, Sourour Yaich, Wafa Abbes, Sana Omri, Lobna Zouari, Nasreddine Zouari, Jamel Dammak, Nada Charfi, Mohamed Maâlej
Under-diagnosed and under-treated, depression has a pejorative prognosis. The general practitioners (GP) represent the most often consulted healthcare professionals by depressed patients. The aim was to describe how the Tunisian GPs manage the depressed patients and to note the difficulties they encounter in order to suggest corrective measures. A survey was conducted among 140 GPs in Sfax Governorate. The percentage of the GPs whose responses conformed to the scientific data in at least 67% of the items was 31...
September 19, 2018: Community Mental Health Journal
Zahid Latif, Imen Chakchouk, Isabelle Schrauwen, Kwanghyuk Lee, Regie Lyn P Santos-Cortez, Izoduwa Abbe, Anushree Acharya, Afeefa Jarral, Imran Ali, Ehsan Ullah, Muhammad Nasim Khan, Ghazanfar Ali, Tufail Hussain Tahir, Michael J Bamshad, Deborah A Nickerson, Wasim Ahmad, Muhammad Ansar, Suzanne M Leal
Purpose: Retinitis pigmentosa (RP) is a genetically heterogeneous trait with autosomal-recessive (ar) inheritance underlying 50% of genetic disease cases. Sixty-one arRP genes have been identified, and recently, DHX38 has been reported as a potential candidate gene for arRP with only a single family reported with a variant of unknown significance. We identified a missense variant in DHX38 that co-segregates with the arRP phenotype in two Pakistani families confirming the involvement of DHX38 in the etiology of early-onset RP...
September 4, 2018: Investigative Ophthalmology & Visual Science
Khadidja Gouttal, Abderrezak Benghalem, Goussem Mimanne, Benhabib Karim
This work is about organic matter removal from Sidi Bel Abbes wastewater plant (Algeria) by coagulation on pillared clays (PILCs) under pH and PZC (point of zero charge), conditions. Two pillared clays, M/Al-PILCs (M = Fe or Mn), were synthesized, characterized, and studied as coagulants. Results showed that Fe/Al-pillared clay exhibits superior efficiency, with 18% higher removal rate than the common coagulants alum (AS) and ferric chloride (FCl), and that sedimentation time has positive effect on turbidity removal, with 95...
September 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Abbe R Gluck, Nicole Huberfeld
The Affordable Care Act (ACA) offers a window into modern American federalism--and modern American nationalism--in action. The ACA's federalism is defined not by separation between state and federal, but rather by a national structure that invites state-led implementation. As it turns out, that structure was only a starting point for a remarkably dynamic and adaptive implementation process that has generated new state-federal arrangements. States move back and forth between different structural models vis-a-vis the federal government; internal state politics produce different state choices; states copy, compete, and cooperate with each other; and negotiation with federal counterparts is a near constant...
June 2018: Stanford Law Review
Mohammed Al Disi, Abdullah Alsalemi, Yahya Alhomsi, Fayçal Bensaali, Abbes Amira, Guillaume Alinier
INTRODUCTION: Extracorporeal membrane oxygenation (ECMO) training programs employ real ECMO components, causing them to be extremely expensive while offering little realism in terms of blood oxygenation and pressure. To overcome those limitations, we are developing a standalone modular ECMO simulator that reproduces ECMO's visual, audio and haptic cues using affordable mechanisms. We present a central component of this simulator, capable of visually reproducing blood oxygenation color change using thermochromism...
September 7, 2018: Perfusion
Selma Maacha, Jun Hong, Ariana von Lersner, Andries Zijlstra, Abbes Belkhiri
Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy that is characterized by resistance to chemotherapy and a poor clinical outcome. The overexpression of the receptor tyrosine kinase AXL is frequently associated with unfavorable prognosis in EAC. Although it is well documented that AXL mediates cancer cell invasion as a downstream effector of epithelial-to-mesenchymal transition, the precise molecular mechanism underlying this process is not completely understood. Herein, we demonstrate for the first time that AXL mediates cell invasion through the regulation of lysosomes peripheral distribution and cathepsin B secretion in EAC cell lines...
September 3, 2018: Neoplasia: An International Journal for Oncology Research
Imen Abbes, Christophe Rihouey, Julie Hardouin, Thierry Jouenne, Emmanuelle De, Stéphane Alexandre
RATIONALE: Pseudomonas aeruginosa is an opportunistic pathogen bacteria widely considered as an excellent research model in several areas of molecular studies, namely genomics and proteomics. However its lipid metabolism is still not totally decrypted. While it is known that this bacterium has the particularity to produce phosphatidylcholine, a lipid mainly found in eukaryotes, other singularities are still to be discovered. METHODS: P. aeruginosa was grown as planktonic cultures to the stationary-state...
September 1, 2018: Rapid Communications in Mass Spectrometry: RCM
Regie Lyn P Santos-Cortez, Valeed Khan, Falak Sher Khan, Zaib-Un-Nisa Mughal, Imen Chakchouk, Kwanghyuk Lee, Memoona Rasheed, Rifat Hamza, Anushree Acharya, Ehsan Ullah, Muhammad Arif Nadeem Saqib, Izoduwa Abbe, Ghazanfar Ali, Muhammad Jawad Hassan, Saadullah Khan, Zahid Azeem, Irfan Ullah, Michael J Bamshad, Deborah A Nickerson, Isabelle Schrauwen, Wasim Ahmad, Muhammad Ansar, Suzanne M Leal
Identification of Mendelian genes for neurodevelopmental disorders using exome sequencing to study autosomal recessive (AR) consanguineous pedigrees has been highly successful. To identify causal variants for syndromic and non-syndromic intellectual disability (ID), exome sequencing was performed using DNA samples from 22 consanguineous Pakistani families with ARID, of which 21 have additional phenotypes including microcephaly. To aid in variant identification, homozygosity mapping and linkage analysis were performed...
September 2018: Human Genetics
Ying Wu, Li Xia, Nian Cai
A refractive index sensor based on an in-line Fabry-Perot interferometer is proposed and experimentally demonstrated. Two lasers are combined and injected into the sensor head. The power responses of two wavelengths are measured by a dual-channel optical power meter simultaneously. The two reflected power signals distribute along an ellipse. The refractive index of the liquid is calculated from the half length of the longer axes of the fitted ellipse. The refractive index sensing system is demonstrated to measure the refractive index of the salt solutions with different concentrations...
September 1, 2018: Optics Letters
Joseph R Schottenfeld, Seth A Waldman, Abbe R Gluck, Daniel G Tobin
Specialists and primary care physicians play an integral role in treating the twin epidemics of pain and addiction. But inadequate access to specialists causes much of the treatment burden to fall on primary physicians. This article chronicles the differences between treatment contexts for both pain and addiction - in the specialty and primary care contexts - and derives a series of reforms that would empower primary care physicians and better leverage specialists.
June 2018: Journal of Law, Medicine & Ethics: a Journal of the American Society of Law, Medicine & Ethics
Abbe R Gluck, Ashley Hall, Gregory Curfman
The devastating impact of the national opioid epidemic has given rise to hundreds of lawsuits. This article details the extremely broad range of legal claims, compares the opioid cases to other public health litigation efforts, including tobacco, and describes the special mechanism - a multidistrict litigation - through which more than 700 opioid-related cases have been consolidated thus far, with settlement almost certain to follow.
June 2018: Journal of Law, Medicine & Ethics: a Journal of the American Society of Law, Medicine & Ethics
Seth A Waldman, Joseph R Schottenfeld, Abbe R Gluck
Excessive prescribing of pain medications after surgery has contributed to the epidemic of opioid misuse and diversion in the United States. Pain specialists may be particularly well situated to address these issues. We describe an attempt to reverse the trend at an orthopedic surgical hospital by implementing a peri-operative assessment and treatment service which minimizes preoperative opioid use, when necessary implements addiction treatment, and encourages early tapering from opioids.
June 2018: Journal of Law, Medicine & Ethics: a Journal of the American Society of Law, Medicine & Ethics
Ian Ayres, Abbe R Gluck, Kate Stith
No abstract text is available yet for this article.
June 2018: Journal of Law, Medicine & Ethics: a Journal of the American Society of Law, Medicine & Ethics
Neringa Jurkute, Anna Majander, Richard Bowman, Marcela Votruba, Stephen Abbs, James Acheson, Guy Lenaers, Patrizia Amati-Bonneau, Mariya Moosajee, Gavin Arno, Patrick Yu-Wai-Man
No abstract text is available yet for this article.
August 24, 2018: European Journal of Human Genetics: EJHG
Jonathan Corren, Mario Castro, Pascal Chanez, Leonardo Fabbri, Vijay N Joish, Nikhil Amin, Neil M H Graham, Vera Mastey, Adeline Abbé, Christine Taniou, Puneet Mahajan, Ariel Teper, Gianluca Pirozzi, Laurent Eckert
No abstract text is available yet for this article.
August 20, 2018: Annals of Allergy, Asthma & Immunology
Jennifer Freeman, Kristen Benito, Jennifer Herren, Joshua Kemp, Jenna Sung, Christopher Georgiadis, Aishvarya Arora, Michael Walther, Abbe Garcia
Pediatric obsessive-compulsive disorder is a chronic and impairing condition that often persists into adulthood. This review refreshes the state of support for psychosocial treatments and the predictors or moderators that relate to their efficacy and evaluates how the literature has improved since the last update in 2014. A secondary goal is to propose an additional framework for the categorization of studies based on central research questions rather than treatment format. Psychosocial treatment studies conducted since the last review are described and evaluated according to methodological rigor and evidence-based classification using the Journal of Clinical Child and Adolescent Psychology evidence-based treatment evaluation criteria...
September 2018: Journal of Clinical Child and Adolescent Psychology
Ian D Ferguson, Patricia Griffin, Joshua J Michel, Hiroshi Yano, Sarah L Gaffen, Robert G Mueller, Jeffrey A Dvergsten, Jon D Piganelli, Margalit E Rosenkranz, Daniel A Kietz, Abbe N Vallejo
T cells are considered autoimmune effectors in juvenile idiopathic arthritis (JIA), but the antigenic cause of arthritis remains elusive. Since T cells comprise a significant proportion of joint-infiltrating cells, we examined whether the environment in the joint could be shaped through the inflammatory activation by T cells that is independent of conventional TCR signaling. We focused on the analysis of synovial fluid (SF) collected from children with oligoarticular and rheumatoid factor-negative polyarticular JIA...
2018: Frontiers in Immunology
Antonin Mikš, Michal Šmejkal
The paper deals with the problem of determination of basic parameters of unknown spherical lenses, namely their radii of curvature, thicknesses, and refractive indices of materials, for example, optical glasses, from which these lenses are made. Four methods are proposed to obtain these parameters and mathematical relations are derived that allow us to determine the refractive index and Abbe number of lens material based on the measured radius values, the thickness, and the position of the focal point or the focal length...
June 10, 2018: Applied Optics
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