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https://www.readbyqxmd.com/read/28712003/association-between-chronic-conditions-and-health-related-quality-of-life-differences-by-level-of-urbanization-in-peru
#1
Alvaro Taype-Rondan, Elizabeth Sarah Abbs, Maria Lazo-Porras, William Checkley, Robert H Gilman, Liam Smeeth, J Jaime Miranda, Antonio Bernabe-Ortiz
PURPOSE: To evaluate the role of urbanization as an effect modifier for the association between specific chronic conditions and number of conditions with health-related quality of life (QOL). METHODS: We analyzed cross-sectional data from the CRONICAS Cohort Study conducted in Lima (highly urbanized), Tumbes (semi-urban), as well as rural and urban sites in Puno. Exposures of interest were chronic bronchitis, depressive mood, hypertension, type 2 diabetes, and a composite variable aggregating the number of chronic conditions (the four exposures plus heart disease and stroke)...
July 15, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28709982/impact-of-zinc-oxide-nanoparticles-on-an-in-vitro-model-of-the-human-air-blood-barrier
#2
Rossella Bengalli, Maurizio Gualtieri, Laura Capasso, Chiara Urani, Marina Camatini
The inhalation of zinc oxide nanoparticles (nZnO) may induce systemic diseases, damages to the alveolar epithelium and inflammatory response to endothelial cells. In this work the use of an in vitro air-blood barrier (ABB) model provided a tool to elucidate the biological mechanisms underlying the potential effects of inhaled nanoparticles (NPs). The ABB model used is composed of a Transwell co-culture of a lung epithelial cell line (NCI-H441) and an immortalized pulmonary microvascular endothelial cell line (HPMEC-ST1...
July 11, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28701203/discovery-of-a-novel-dominant-mutation-in-the-ren-gene-after-forty-years-of-renal-disease-a-case-report
#3
Rhian L Clissold, Helen C Clarke, Olivera Spasic-Boskovic, Kim Brugger, Stephen Abbs, Coralie Bingham, Charles Shaw-Smith
BACKGROUND: Heterozygous mutations in the gene encoding renin (REN) cause autosomal dominant tubulointerstitial kidney disease (ADTKD), early-onset anaemia and hyperuricaemia; only four different mutations have been described in the published literature to date. We report a novel dominant REN mutation discovered in an individual after forty years of renal disease. CASE PRESENTATION: A 57 year old Caucasian woman with chronic kidney disease stage five was reviewed in a regional joint renal genetics clinic...
July 12, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28697022/an-examination-of-traffic-related-traumatic-injuries-among-children-at-a-level-1-pediatric-trauma-center-2005-2014
#4
Ping Ma, Nazia Hussain, Marisa Abbe
BACKGROUND: Traffic-related injuries are the leading fatal injury among children in the US, but no published study compares the different types of traffic-related pediatric injuries to date. Thus, this study aims to examine the10 year trend of traffic-related injury among children at a pediatric hospital and to assess if there were differences in injury mechanism. METHODS: All data were drawn from a Level-1 Pediatric Trauma center in North Texas 2005-2014. Demographic characteristics, length of hospitalization (LOS) and patient type were included...
July 8, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28683353/imaging-with-straight-edge-phase-plates-in-the-tem
#5
C J Edgcombe
The image of a simple phase object produced by a round lens with a Foucault or Hilbert phase plate can be determined with Abbe imaging theory and a 2D transform expressed in cylindrical coordinates. The contributions to the image amplitude from a uniform disc object and an azimuthally varying plate can then be distinguished and their phases relative to the incident wave can be compared. It appears that the usual choice of added phase for a Hilbert plate causes the image of a weak disc object to vanish as the plate edge approaches the axis, but a different choice of plate thickness can enable a weak phase object to provide a linear contribution to image intensity...
June 22, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28678863/early-positivity-signals-changes-in-an-abstract-linguistic-pattern
#6
Júlia Monte-Ordoño, Juan M Toro
The extraction of abstract structures from speech (or from gestures in the case of sign languages) has been claimed to be a fundamental mechanism for language acquisition. In the present study we registered the neural responses that are triggered when a violation of an abstract, token-independent rule is detected. We registered ERPs while presenting participants with trisyllabic CVCVCV nonsense words in an oddball paradigm. Standard stimuli followed an ABB rule (where A and B are different syllables). Importantly, to distinguish neural responses triggered by changes in surface information from responses triggered by changes in the underlying abstract structure, we used two types of deviant stimuli...
2017: PloS One
https://www.readbyqxmd.com/read/28662225/complete-philtrum-reconstruction-on-the-partial-thickness-cross-lip-flap-by-nasolabial-muscle-tension-line-group-reconstruction-in-the-same-stage-of-flap-transfer
#7
Ningbei Yin, Di Wu, Yongqian Wang, Tao Song, Haidong Li, Chanyuan Jiang, Hengyuan Ma, Zhenmin Zhao
Importance: The blood supply pattern of the partial-thickness musculomucosal pedicle flaps is different from the traditional Abbe flap. The arterial blood supply and venous drainage are highly reliable during clinical practice. Objective: To describe the reconstruction of the philtrum in the cross-lip flap transfer using nasolabial muscle tension line group reconstruction. Design, Setting, and Participants: From January 1, 2014, through June 31, 2015, a total of 6 patients with upper lip defect were treated with philtrum reconstruction in the same stage of the split cross-lip flap transfer at the Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China...
June 29, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28656032/threefold-rotational-symmetry-in-hexagonally-shaped-core-shell-in-ga-as-gaas-nanowires-revealed-by-coherent-x-ray-diffraction-imaging
#8
Arman Davtyan, Thilo Krause, Dominik Kriegner, Ali Al-Hassan, Danial Bahrami, Seyed Mohammad Mostafavi Kashani, Ryan B Lewis, Hanno Küpers, Abbes Tahraoui, Lutz Geelhaar, Michael Hanke, Steven John Leake, Otmar Loffeld, Ullrich Pietsch
Coherent X-ray diffraction imaging at symmetric hhh Bragg reflections was used to resolve the structure of GaAs/In0.15Ga0.85As/GaAs core-shell-shell nanowires grown on a silicon (111) substrate. Diffraction amplitudes in the vicinity of GaAs 111 and GaAs 333 reflections were used to reconstruct the lost phase information. It is demonstrated that the structure of the core-shell-shell nanowire can be identified by means of phase contrast. Interestingly, it is found that both scattered intensity in the (111) plane and the reconstructed scattering phase show an additional threefold symmetry superimposed with the shape function of the investigated hexagonal nanowires...
June 1, 2017: Journal of Applied Crystallography
https://www.readbyqxmd.com/read/28623362/super-resolution-microscopy-with-very-large-working-distance-by-means-of-distributed-aperture-illumination
#9
Udo Birk, Johann V Hase, Christoph Cremer
The limits of conventional light microscopy ("Abbe-Limit") depend critically on the numerical aperture (NA) of the objective lens. Imaging at large working distances or a large field-of-view typically requires low NA objectives, thereby reducing the optical resolution to the multi micrometer range. Based on numerical simulations of the intensity field distribution, we present an illumination concept for a super-resolution microscope which allows a three dimensional (3D) optical resolution around 150 nm for working distances up to the centimeter regime...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28592168/homozygous-mutation-on-the-%C3%AE-globin-polyadenylation-signal-in-a-tunisian-patient-with-%C3%AE-thalassemia-intermedia-and-coinheritance-of-gilbert-s-syndrome
#10
Faten Haddad, Nawel Trabelsi, Leila Chaouch, Imen Darragi, Meriem Oueslati, Imen Boudriga, Dorra Chaouachi, Wijdene El-Borgi, Raouf Hafsia, Salem Abbes, Houyem Ouragini
We report here the clinical, hematological and molecular data in a 50-year-old patient with β-thalassemia intermedia (β-TI) caused by a homozygous β(+) mutation on the β-globin gene polyadenylation (polyA) signal (AATAAA>AAAAAA). β Haplotype analysis was accomplished by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Haplotype and framework analysis showed that this mutation is associated with the [- - - - + + +] β haplotype and framework 1 (CCGCT) (FW1). This mutation was previously reported in the heterozygous state in association with the codon 9 (+TA) mutation in a β-TI patient originating from Tunisia...
March 2017: Hemoglobin
https://www.readbyqxmd.com/read/28560049/measurement-of-refractive-indices-of-tunicates-tunics-light-reflection-of-the-transparent-integuments-in-an-ascidian-rhopalaea-sp-and-a-salp-thetys-vagina
#11
Hiroshi Kakiuchida, Daisuke Sakai, Jun Nishikawa, Euichi Hirose
BACKGROUND: Tunic is a cellulosic, integumentary matrix found in tunicates (Subphylum Tunicata or Urochordata). The tunics of some ascidian species and pelagic tunicates, such as salps, are nearly transparent, which is useful in predator avoidance. Transparent materials can be detected visually using light reflected from their surfaces, with the different refractive indices between two media, i.e., tunic and seawater, being the measure of reflectance. A larger difference in refractive indices thus provides a larger measure of reflectance...
2017: Zoological Letters
https://www.readbyqxmd.com/read/28554544/immuno-nephelometric-determination-of-group-streptococcal-anti-streptolysin-o-titres-asot-from-dried-blood-spots-method-for-validating-a-new-assay
#12
John Joseph, Neil Kent, Asha Bowen, Julie Hart, Meru Sheel, Robert Wardrop, Sam Abbs, Scott Bazely, Monika Rybak
This study was designed to determine the sensitivity and reproducibility of recovering anti-streptolysin O titres (ASOT) from dried blood spot (DBS) samples, a methodologic subcomponent of the penicillin pharmacokinetic studies in children receiving secondary prophylaxis with intramuscular benzathine penicillin for acute rheumatic fever.
May 26, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28544699/renal-anomalies-and-lymphedema-distichiasis-syndrome-a-rare-association
#13
Gabriela E Jones, Anna K Richmond, Osric Navti, Hatem A Mousa, Stephen Abbs, Edward Thompson, Sahar Mansour, Pradeep C Vasudevan
Lymphedema distichiasis syndrome (LDS) is a rare, autosomal dominant genetic condition, characterized by lower limb lymphedema and distichiasis. Other associated features that have been reported include varicose veins, cleft palate, congenital heart defects, and ptosis. We update a previously reported family with a pathogenic variant in FOXC2 (c.412-413insT) where five affected individuals from the youngest generation had congenital renal anomalies detected on prenatal ultrasound scan. These included four fetuses with hydronephrosis and one with bilateral renal agenesis...
May 23, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28538893/lower-lip-reconstruction-using-a-skin-mucosa-abbe-estlander-flap-after-squamous-cell-carcinoma-excision
#14
Husein Husein-ElAhmed, Rafael Armijo-Lozano
Lips are structures that play an essential role in aesthetics and in different functions such as nutrition and speech. The complex anatomy of the lips - with three different layers composed of skin, mucosa, and muscles - makes surgical management of this area a therapeutic challenge. The use of flaps for the reconstruction of large defects with low risk of necrosis is possible given the abundant blood supply of the lips. We report a case of surgical reconstruction of the lower lip after the excision of a severe squamous cell carcinoma using a skin-mucosa Abbe-Estlander flap with a satisfactory final outcome...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28532431/high-prevalence-of-cardiovascular-risk-factors-in-peruvian-adolescents-living-in-a-peri-urban-shantytown-a-cross-sectional-study
#15
Elizabeth S Abbs, José Viñoles, Jorge O Alarcón, Heather M Johnson, Joseph R Zunt
BACKGROUND: Adults of the peri-urban Peruvian shantytown of Lomas de Zapallal have a high prevalence of risk factors for developing cardiovascular disease (CVD)-likely due to behavioral choices established during childhood and adolescence. To guide the development of community-based risk reduction programs, we assessed the prevalence of risk factors for developing CVD among adolescents. METHODS: We collected cross sectional data from adolescents of Peruvian peri-urban shantytown to evaluate four domains of CVD risk factors: (1) clinical (blood pressure, fasting blood glucose, and blood lipids), (2) anthropometric (height, weight, and waist circumference), (3) behavioral (physical activity, diet, and substance abuse), and (4) psychosocial (mental health and violence)...
May 22, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/28508033/over-the-scope-clip-otsc-reduces-surgery-rate-in-the-management-of-iatrogenic-gastrointestinal-perforations
#16
Sherine Khater, Gabriel Rahmi, Guillaume Perrod, Elia Samaha, Hedi Benosman, Leila Abbes, Georgia Malamut, Christophe Cellier
Background and study aims Over-the-scope clip (OTSC) has been recently used in management of gastrointestinal perforations, but data on it are still limited. The aim of this study was to compare management of iatrogenic perforations before and after the OTSC was available in our endoscopy unit. Patients and methods We conducted a monocentric retrospective study from June 2007 to June 2015. All iatrogenic gastrointestinal perforations detected during endoscopy were included. Two time periods were compared in terms of surgery and mortality rates: before use of OTSC (June 2007 to June 2011) and after OTSC became available (June 2011 to June 2015)...
May 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28506454/esophageal-intramural-pseudodiverticulosis-a-rare-cause-of-stenosis
#17
Leila Abbes, Guillaume Perrod, Gabriel Rahmi, Christophe Cellier
No abstract text is available yet for this article.
May 11, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28497491/male-child-with-somatic-mosaic-osteopathia-striata-with-cranial-sclerosis-caused-by-a-novel-pathogenic-amer1-frameshift-mutation
#18
Jennifer Hague, Isabelle Delon, Kim Brugger, Howard Martin, Leanne Sparnon, Ingrid Simonic, Stephen Abbs, Soo-Mi Park
Osteopathia striata with cranial sclerosis (OSCS; OMIM #300373) is a rare X-linked dominant condition caused by mutations in the AMER1 gene (also known as WTX or FAM123B). It is a condition which usually affects females in whom the clinical phenotype can be extremely variable. Conversely affected males typically die in utero or during the neonatal period [Perdu et al. (); Clinical Genetics 80: 383-388; Vasiljevic et al. (); Prenatal Diagnosis 35: 302-304]. There have been a small number of reported cases of surviving males, including three patients who are somatic mosaic for the condition [Chénier, Noor, Dupuis, Stavropoulos, & Mendoza-Londono, (); American Journal of Medical Genetics Part A 158A: 2946-2952; Holman et al...
May 12, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28494043/maxillary-sinus-floor-augmentation-using-xenograft-gene-expression-and-histologic-analysis
#19
Jaijam Suwanwela, Dollaya Puangchaipruk, Kamolporn Wattanasirmkit, Paksinee Kamolratanakul, Pornchai Jansisyanont
PURPOSE: Many histologic and histomorphometric studies as well as systematic reviews have shown the clinical success of the use of anorganic bovine bone (ABB, Bio-Oss) in maxillary sinus floor augmentation (MSFA). The molecular processes involved in bone healing are, however, still unknown. The aims of this study were to explore gene expression associated with bone remodeling and inflammation in MSFA sites. MATERIALS AND METHODS: The mRNA expression levels of runt related transcription factor 2 (RUNX2), receptor activator of NF-kB ligand (RANKL), osteoprotegerin (OPG), matrix metallopeptidase 9 (MMP-9), tartrate-resistance acid phosphatase (TRAP), and interleukin-1beta (IL-1β), as well as the ratio of RANKL/OPG were compared between alveolar bone of a group after MSFA with ABB and a maxillary posterior edentulous bone group...
May 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28481278/combining-low-temperature-fluorescence-dna-hybridization-immunostaining-and-super-resolution-localization-microscopy-for-nano-structure-analysis-of-alu-elements-and-their-influence-on-chromatin-structure
#20
Matthias Krufczik, Aaron Sievers, Annkathrin Hausmann, Jin-Ho Lee, Georg Hildenbrand, Wladimir Schaufler, Michael Hausmann
Immunostaining and fluorescence in situ hybridization (FISH) are well established methods for specific labelling of chromatin in the cell nucleus. COMBO-FISH (combinatorial oligonucleotide fluorescence in situ hybridization) is a FISH method using computer designed oligonucleotide probes specifically co-localizing at given target sites. In combination with super resolution microscopy which achieves spatial resolution far beyond the Abbe Limit, it allows new insights into the nano-scaled structure and organization of the chromatin of the nucleus...
May 7, 2017: International Journal of Molecular Sciences
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