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https://www.readbyqxmd.com/read/28508033/over-the-scope-clip-otsc-reduces-surgery-rate-in-the-management-of-iatrogenic-gastrointestinal-perforations
#1
Sherine Khater, Gabriel Rahmi, Guillaume Perrod, Elia Samaha, Hedi Benosman, Leila Abbes, Georgia Malamut, Christophe Cellier
Background and study aims Over-the-scope clip (OTSC) has been recently used in management of gastrointestinal perforations, but data on it are still limited. The aim of this study was to compare management of iatrogenic perforations before and after the OTSC was available in our endoscopy unit. Patients and methods We conducted a monocentric retrospective study from June 2007 to June 2015. All iatrogenic gastrointestinal perforations detected during endoscopy were included. Two time periods were compared in terms of surgery and mortality rates: before use of OTSC (June 2007 to June 2011) and after OTSC became available (June 2011 to June 2015)...
May 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28506454/esophageal-intramural-pseudodiverticulosis-a-rare-cause-of-stenosis
#2
Leila Abbes, Guillaume Perrod, Gabriel Rahmi, Christophe Cellier
No abstract text is available yet for this article.
May 11, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28497491/male-child-with-somatic-mosaic-osteopathia-striata-with-cranial-sclerosis-caused-by-a-novel-pathogenic-amer1-frameshift-mutation
#3
Jennifer Hague, Isabelle Delon, Kim Brugger, Howard Martin, Leanne Sparnon, Ingrid Simonic, Stephen Abbs, Soo-Mi Park
Osteopathia striata with cranial sclerosis (OSCS; OMIM #300373) is a rare X-linked dominant condition caused by mutations in the AMER1 gene (also known as WTX or FAM123B). It is a condition which usually affects females in whom the clinical phenotype can be extremely variable. Conversely affected males typically die in utero or during the neonatal period [Perdu et al. (); Clinical Genetics 80: 383-388; Vasiljevic et al. (); Prenatal Diagnosis 35: 302-304]. There have been a small number of reported cases of surviving males, including three patients who are somatic mosaic for the condition [Chénier, Noor, Dupuis, Stavropoulos, & Mendoza-Londono, (); American Journal of Medical Genetics Part A 158A: 2946-2952; Holman et al...
May 12, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28494043/maxillary-sinus-floor-augmentation-using-xenograft-gene-expression-and-histologic-analysis
#4
Jaijam Suwanwela, Dollaya Puangchaipruk, Kamolporn Wattanasirmkit, Paksinee Kamolratanakul, Pornchai Jansisyanont
PURPOSE: Many histologic and histomorphometric studies as well as systematic reviews have shown the clinical success of the use of anorganic bovine bone (ABB, Bio-Oss) in maxillary sinus floor augmentation (MSFA). The molecular processes involved in bone healing are, however, still unknown. The aims of this study were to explore gene expression associated with bone remodeling and inflammation in MSFA sites. MATERIALS AND METHODS: The mRNA expression levels of runt related transcription factor 2 (RUNX2), receptor activator of NF-kB ligand (RANKL), osteoprotegerin (OPG), matrix metallopeptidase 9 (MMP-9), tartrate-resistance acid phosphatase (TRAP), and interleukin-1beta (IL-1β), as well as the ratio of RANKL/OPG were compared between alveolar bone of a group after MSFA with ABB and a maxillary posterior edentulous bone group...
May 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28481278/combining-low-temperature-fluorescence-dna-hybridization-immunostaining-and-super-resolution-localization-microscopy-for-nano-structure-analysis-of-alu-elements-and-their-influence-on-chromatin-structure
#5
Matthias Krufczik, Aaron Sievers, Annkathrin Hausmann, Jin-Ho Lee, Georg Hildenbrand, Wladimir Schaufler, Michael Hausmann
Immunostaining and fluorescence in situ hybridization (FISH) are well established methods for specific labelling of chromatin in the cell nucleus. COMBO-FISH (combinatorial oligonucleotide fluorescence in situ hybridization) is a FISH method using computer designed oligonucleotide probes specifically co-localizing at given target sites. In combination with super resolution microscopy which achieves spatial resolution far beyond the Abbe Limit, it allows new insights into the nano-scaled structure and organization of the chromatin of the nucleus...
May 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28451069/posttraumatic-growth-and-depreciation-six-years-after-the-2004-tsunami
#6
Hans Michélsen, Charlotte Therup-Svedenlöf, Magnus Backheden, Abbe Schulman
Background: Posttraumatic growth (PTG) has been reported after various types of potentially traumatic events, as a part of the personal recovery process among survivors. Even negative changes in survivors' life view, known as posttraumatic depreciation (PTD), have been identified as an additional aspect in the personal recovery processes. Objective: To examine how the type of exposure experienced by survivors of a natural disaster, the 2004 Southeast Asia tsunami, influenced self-reported PTG and PTD six years later (T2)...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/28417568/cisplatin-resistant-cancer-cells-are-sensitive-to-aurora-kinase-a-inhibition-by-alisertib
#7
Lihong Wang, Janet Arras, Ahmed Katsha, Saif Hamdan, Abbes Belkhiri, Jeffrey Ecsedy, Wael El-Rifai
De novo and acquired resistance to platinum therapy such as cisplatin (CDDP) is a clinical challenge in gastric cancer treatment. Aberrant expression and activation of Aurora kinase A (AURKA) and eukaryotic translation initiation factor 4E (eIF4E) are detected in several cancer types. Herein, we investigated the role of AURKA in CDDP resistance in gastric cancer. Western blot analysis demonstrated overexpression of AURKA and phosphorylation of eIF4E in acquired and de novo CDDP-resistant gastric cancer models...
April 18, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28412602/secondary-outcomes-from-the-pediatric-obsessive-compulsive-disorder-treatment-study-ii
#8
Christine A Conelea, Robert R Selles, Kristen G Benito, Michael M Walther, Jason T Machan, Abbe M Garcia, Jeffrey Sapyta, Sarah Morris, Martin Franklin, Jennifer B Freeman
The Pediatric Obsessive-Compulsive Disorder Treatment Study II (POTS II) investigated the benefit of serotonin reuptake inhibitor (SRI) augmentation with cognitive behavioral therapy (CBT). Primary outcomes focused on OCD symptom change and indicated benefit associated with a full course of CBT. Given that the majority of youth with OCD suffer from significant comorbid symptoms and impaired quality of life, the current study examined POTS II data for effects on secondary outcomes. Participants were 124 youth ages 7-17 years with a primary diagnosis of OCD who were partial responders to an adequate SRI trial...
April 7, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28392650/transoral-cross-lip-abb%C3%A3-estlander-flap-as-a-viable-and-effective-reconstructive-option-in-middle-lower-lip-defect-reconstruction
#9
Hyung Jin Hahn, Hyun Jee Kim, Jin Young Choi, Soo Young Lee, Young Bok Lee, Jin Wou Kim, Dong Soo Yu
The Abbé-Estlander flap surgery is a cross-lip procedure that is valuable in repairing a defect on the lower lip using a full-thickness flap, consisting of the skin, muscle and mucosa, from the upper lip. As usefulness and practicality of the flap in reconstruction of lower lip surgical defects in Asian ethnicity have not been documented, the authors present a case of successful lower lip reconstruction with a staged, Abbé-Estlander lip switching flap with commissuroplasty as an illustrative example. A 71-year-old male has presented with an ulcerating lip nodule in the middle one third of the lower lip, measuring about 1...
April 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28379687/kinetic-requirements-for-spatiotemporal-chemical-imaging-with-fluorescent-nanosensors
#10
Daniel Meyer, Annika Hagemann, Sebastian Kruss
Fluorescent nanosensors are powerful tools for basic research and bioanalytical applications. Individual nanosensors are able to detect single molecules, while ensembles of nanosensors can be used to measure the bulk concentration of an analyte. Collective imaging of multiple nanosensors could provide both spatial and temporal chemical information from the nano- to the microscale. This type of chemical imaging with nanosensors would be very attractive to study processes such as chemical signaling between cells (e...
April 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28372910/structure-activity-relationship-and-optimization-of-n-3-2-aminothiazol-4-yl-aryl-benzenesulfonamides-as-anti-cancer-compounds-against-sensitive-and-resistant-cells
#11
Cyril Ronco, Antoine Millet, Magali Plaisant, Patricia Abbe, Nedra Hamouda-Tekaya, Stéphane Rocchi, Rachid Benhida
We recently described a new family of bioactive molecules with interesting anti-cancer activities: the N-(4-(3-aminophenyl)thiazol-2-yl)acetamides. The lead compound of the series (1) displays significant anti-proliferative and cytotoxic activities against a panel of cancer cell lines, either sensitive or resistant to standard treatments. This molecule also shows a good pharmacological profile and high in vivo potency towards mice xenografts, without signs of toxicity on the animals. In the present article, we disclose the structure-activity relationships of this lead compound, which have provided clear information about the replacement of the acetamide function and the substitution pattern of the benzenesulfonamide ring...
March 23, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28370111/the-addition-effect-of-tunisian-date-seed-fibers-on-the-quality-of-chocolate-spreads
#12
Mohamed Ali Bouaziz, Fatma Abbes, Abir Mokni, Christophe Blecker, Hamadi Attia, Souhail Besbes
Novel chocolate spreads were enriched by soluble and insoluble dietary fibers from Tunisian Deglet Nour date seeds at 1, 2, 3, 4, and 5% levels in the conventional chocolate spread. Defatted Deglet Nour date seeds, date seed soluble fiber concentrate (DSSFC) and date seed insoluble fiber concentrate (DSIFC) were characterized by high levels of dietary fibers (80-90%). Chocolate spread enriched with 5% of DSSFC presented the highest oil binding capacity (304.62%) compared to the control (102%). Whatever the DSIFC and DSSFC incorporation levels, no significant difference was recorded between the firmness, chewiness, and adhesiveness of prepared chocolate spreads compared to the control (p < ...
April 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28359810/an-approach-for-chemical-stability-during-melt-extrusion-of-a-drug-substance-with-a-high-melting-point
#13
Abbe Haser, Siyuan Huang, Tony Listro, David White, Feng Zhang
Poorly water-soluble drug substances that exhibit high melting points are difficult to process by melt extrusion due to chemical instability at high temperatures required for processing. The purpose of this study was to extrude meloxicam (melting point 255°C) by optimizing processing parameters and formulation composition. Five extrusion studies were performed: 1) design space, 2) impact of moisture, 3) impact of melt residence time, 4) specific energy optimization, and 5) altered microenvironment pH. Powder X-ray diffraction and polarized light microscopy were used to confirm amorphous conversion...
March 28, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28323561/immobilization-of-asiatic-black-bears-ursus-thibetanus-with-medetomidine-zolazepam-tiletamine-in-south-korea
#14
Dong-Hyuk Jeong, Jeong-Jin Yang, Seong-Hoon Seok, Byeung-Cheul Song, Seong-Chan Yeon
The Asiatic black bear ( Ursus thibetanus ; ABB) is a globally endangered species for which a restoration program has been ongoing in South Korea since 2001. However, there is little information on immobilization protocols for ABBs. We evaluated the use of medetomidine-zolazepam-tiletamine for their immobilization. During 2005-2013, we anesthetized 60 ABBs (32 males, 28 females; 7 mo to 12 yr old) with medetomidine 0.03-0.045 mg/kg and zolazepam-tiletamine 1.54-2.3 mg/kg; reversal of anesthesia was done with atipamezole 0...
March 21, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28315285/effects-of-plyometric-training-on-physical-fitness-in-prepuberal-soccer-athletes
#15
Yassine Negra, Helmi Chaabene, Senda Sammoud, Raja Bouguezzi, Mohamed Aymen Abbes, Younés Hachana, Urs Granacher
This study aimed at examining the effects of plyometric training on stable (SPT) vs. unstable (UPT) surfaces on physical fitness in prepuberal soccer players. Male athletes were randomly assigned to SPT (n=18; age=12.7±0.2 years) or UPT (n=16; age=12.2±0.5 years). Both groups conducted 3 regular soccer training sessions per week combined with either 2 SPT or UPT sessions. Assessment of jumping ability (countermovement jump [CMJ], and standing long jump [SLJ]), speed (10-m, 20-m, 30-m sprint), agility (Illinois agility test [IAT]), and balance (stable [SSBT], unstable [USBT] stork balance test; stable [SYBT], unstable [UYBT] Y balance test) was conducted pre-and post-training...
May 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28291857/effect-of-maxillary-sinus-membrane-perforation-on-implant-survival-rate-a-retrospective-study
#16
Carlos Eduardo de Almeida Ferreira, Carolina Borges Martinelli, Arthur Belém Novaes, Túlio Bonna Pignaton, Camila Coser Guignone, Adriana Luísa Gonçalves de Almeida, Eduardo Saba-Chujfi
PURPOSE: The aim of this retrospective study was to evaluate implant survival rates (ISRs) for implants placed in grafted sinuses where a membrane perforation occurred during augmentation using exclusively anorganic bovine bone (ABB) by means of clinical and radiographic examinations. Histologic information of five biopsy specimens taken from large membrane perforations is also presented. MATERIALS AND METHODS: Consecutive patients who underwent sinus augmentation procedures at a private practice Dental Institute between 2004 and 2013 were collected from a computer database...
March 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28286932/hoct1-gene-expression-predict-for-optimal-response-to-imatinib-in-tunisian-patients-with-chronic-myeloid-leukemia
#17
Islem Ben Hassine, Hanene Gharbi, Ismail Soltani, Mouheb Teber, Ahlem Farrah, Hind Ben Hadj Othman, Hassiba Amouri, Hatem Bellaaj, Rayhane Ben Lakhal, Neila Ben Romdhane, Salem Abbes, Samia Menif
PURPOSE: Imatinib mesylate (IM) is considered as a highly effective therapy for chronic myeloid leukemia (CML) patients. However, a minority of patients fail to achieve optimal response due to impaired bioavailability of IM. The human organic cation transporter 1 (OCT1; SLC22A1) has been reported to be the main influx transporter involved in IM uptake into CML cells. Genetic variants and/or hOCT1 expression changes may influence IM response. In this study, we aimed to investigate the impact of both hOCT1 polymorphisms located in exon 7 and hOCT1 mRNA levels on the clinical outcome in CML patients...
March 12, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28281364/chemical-composition-antioxidant-and-antibacterial-activities-of-tamarix-balansae-j-gay-aerial-parts
#18
Abbes Benmerache, Mounira Benteldjoune, Abdulmagid Alabdul Magid, Amin Abedini, Djemaa Berrehal, Ahmed Kabouche, Sophie C Gangloff, Laurence Voutquenne-Nazabadioko, Zahia Kabouche
A previously undescribed phenolic sulphate ester, potassium 34-dihydroxy-3-methoxybenzoic acid methyl ester-5-sulphate (1), along with nine known flavonoids, kaempferol-3-O-potassium sulphate-4',7-dimethyl ether (2), kaempferol-4',7-dimethyl ether (3), rhamnocitrin-3-O-potassium sulphate (4), rhamnocitrin (5), kaempferol (6), quercetin (7), afzelin (8), quercetin-3-O-α-l-rhamnopyranoside (9) and luteolin-3'-O-potassium sulphate (10) were isolated from the aerial parts of Tamarix balansae. Structures elucidation was performed by comprehensive 1D and 2D NMR analyses, mass spectrometry and by comparison with literature data...
March 10, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28277720/artificial-grammar-learning-in-tamarins-saguinus-oedipus-in-varying-stimulus-contexts
#19
Julie J Neiworth, Justin M London, Michael J Flynn, Deborah D Rupert, Owen Alldritt, Caleb Hyde
The human ability to detect regularities in sound sequences is a fundamental substrate of our language faculty. However, is this an ability exclusive to human language processing, or have we usurped a more general learning mechanism for this purpose, one shared with other species? The current study is an attempt to replicate and extend Hauser, Weiss, and Marcus's (2002) retracted study (2010) of artificial grammar learning in tamarins to determine if tamarins can detect an underlying grammatical structure in a pattern of sounds...
May 2017: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/28259831/melt-extrusion-vs-spray-drying-the-effect-of-processing-methods-on-crystalline-content-of-naproxen-povidone-formulations
#20
Abbe Haser, Tu Cao, Joe Lubach, Tony Listro, Larry Acquarulo, Feng Zhang
Our hypothesis is that melt extrusion is a more suitable processing method than spray drying to prepare amorphous solid dispersions of drugs with a high crystallization tendency. Naproxen-povidone K25 was used as the model system in this study. Naproxen-povidone K25 solid dispersions at 30% and 60% drug loadings were characterized by modulated DSC, powder X-ray diffraction, FT-IR, and solid-state (13)C NMR to identify phase separation and drug recrystallization during processing and storage. At 30% drug loading, hydrogen bond (H-bond) sites of povidone K25 were not saturated and the glass transition (Tg) temperature of the formulation was higher...
March 1, 2017: European Journal of Pharmaceutical Sciences
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