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Hui-Wen Lu-Walther, Wenya Hou, Martin Kielhorn, Yoshiyuki Arai, Takeharu Nagai, Michael M Kessels, Britta Qualmann, Rainer Heintzmann
Structured illumination microscopy (SIM) is a wide-field technique in fluorescence microscopy that provides fast data acquisition and two-fold resolution improvement beyond the Abbe limit. We observed a further resolution improvement using the nonlinear emission response of a fluorescent protein. We demonstrated a two-beam nonlinear structured illumination microscope by introducing only a minor change into the system used for linear SIM (LSIM). To achieve the required nonlinear dependence in nonlinear SIM (NL-SIM) we exploited the photoswitching of the recently introduced fluorophore Kohinoor...
2016: PloS One
P Sławuta, G Sapikowski, B Sobieraj
: Buffer systems of blood and tissues, which have the ability to bind with and give up hydrogen ions, participate in maintaining the acid-base balance (ABB) of the organism. According to the classic model, the system of carbonic acid and bicarbonates, where the first component serves the role of an acid and the second a base, determines plasma pH. The so-called Stewart model, which assumes that ions in blood serum can be separated into completely dissociated - nonbuffer and not dissociated - buffer ions which may give up or accept H+ions, also describes the ABB of the organism...
September 1, 2016: Polish Journal of Veterinary Sciences
Monia Ouederni, Monia Ben Khaled, Fethi Mellouli, Elhem Ben Fraj, Nawel Dhouib, Ismehen Ben Yakoub, Selem Abbes, Nejla Mnif, Mohamed Bejaoui
Thalassemia is a common genetic disorder in Tunisia. Early iron concentration assessment is a crucial and challenging issue. Most of annual deaths due to iron overload occurred in underdeveloped regions of the world. Limited access to liver and heart MRI monitoring might partially explain these poor prognostic results. Standard software programs are not available in Tunisia. This study is the first to evaluate iron overload in heart and liver using the MRI T2* with excel spreadsheet for post processing. Association of this MRI tool results to serum ferritin level, and echocardiography was also investigated...
October 12, 2016: Annals of Hematology
Shintaro Maekawa, Krzysztof Moorthi, Yasuteru Shigeta
Refractive indices of metal- and metalloid-containing compounds are systematically evaluated using the Lorentz-Lorenz equation with polarizabilities obtained via density functional theory (DFT). Among exchange-correlation functionals studied, the long-range corrected (LC) fuctionals yield the lowest errors for the polarizabilities of gaseous compounds and refractive indices of liquids. The LC-DFT predicts very well the wavelength dependence of refractive indices. A scheme for computing Abbe numbers of organometallic and organometaloid compounds is proposed and a refractive index - Abbe number plot for 80 compounds is constructed...
October 6, 2016: Journal of Computational Chemistry
Haie Zhu, Wen Fan, Shuxue Zhou, Min Chen, Limin Wu
Optical microscope is widely used real-time investigation tool, but usually suffers from low resolution due to Abbe diffraction limit. Herein, we design and successfully synthesize ZrO2/polymer hybrid colloidal microspheres with as high as 47.5 wt% inorganic nanoparticles by suspension polymerization of 9,9'-bis[4-(2-acryloyloxyethyloxy) phenyl] fluorene (BAEPF). Owing to the homogeneous dispersion, high density and high refractive index of inorganic nanoparticles and deformability of polymer, the obtained ZrO2/poly(BAEPF) hybrid colloidal microspheres have high refractive index, optical transparency and controllable curvature, and thus can be directly used as a hybrid solid immersion lens (hSIL) for optical microscope, achieving super-resolution imaging of 50 nm even 45 nm under a standard white light or blue light optical microscopes, which is far beyond the diffraction limit for visible light optical microscopes...
October 4, 2016: ACS Nano
Jenny Herren, Jennifer Freeman, Abbe Garcia
Cognitive-behavioral therapy (CBT) using exposure with response prevention (ERP) is the treatment of choice for obsessive-compulsive disorder (OCD); however, developmental modifications should be considered when treating young children. This article presents a case study illustrating family-based CBT using ERP with a 7-year-old boy. The delivery of ERP for this case was guided by 3 main principles: (a) family involvement with a focus on reducing family accommodation, (b) understanding the functional relation between the client's obsessions and compulsions, and (c) creating conditions to facilitate habituation during exposure...
November 2016: Journal of Clinical Psychology
Ming Luo, Xing-Hong Zhang, Donald J Darensbourg
Carbonyl sulfide (COS) is an air pollutant that causes acid rain, ozonosphere damage, and carbon dioxide (CO2) generation. It is a heterocumulene and structural analogue of CO2. Relevant to organic synthesis, it is a source of C═O or C═S groups and thus an ideal one-carbon (C1) building block for synthesizing sulfur-containing polymers through the similar route of CO2 copolymerization. In contrast, traditional synthesis of sulfur-containing polymers often involves the condensation of thiols with phosgene and ring-opening polymerization of cyclic thiocarbonates that are generally derived from thiols and phosgene; thus, COS/epoxide copolymerization is a "greener" route to supplement or supplant current processes for the production of sulfur-containing polymers...
October 18, 2016: Accounts of Chemical Research
Jing Wang, Yunlong Sheng
A new approach for designing the binary computer-generated hologram (CGH) of a very large number of pixels is proposed. Diffraction of the CGH apertures is computed by the analytical Abbe transform and by considering the aperture edges as the basic diffracting elements. The computation cost is independent of the CGH size. The arbitrary-shaped polygonal apertures in the CGH consist of quadrilateral apertures, which are designed by assigning the binary phases using the parallel genetic algorithm with a local search, followed by optimizing the locations of the co-vertices with a direct search...
September 20, 2016: Applied Optics
Ismael Soltani, Hanen Gharbi, Islem Ben Hassine, Ghada Bouguerra, Kais Douzi, Mouheb Teber, Salem Abbes, Samia Menif
Targeted therapy in the form of selective breakpoint cluster region-abelson (BCR/ABL) tyrosine kinase inhibitor (imatinib mesylate) has successfully been introduced in the treatment of the chronic myeloid leukemia (CML). However, acquired resistance against imatinib mesylate (IM) has been reported in nearly half of patients and has been recognized as major issue in clinical practice. Multiple resistance genes and microRNAs (miRNAs) are thought to be involved in the IM resistance process. These resistance genes and miRNAs tend to interact with each other through a regulatory network...
September 16, 2016: Functional & Integrative Genomics
Otto Schück, Miroslava Horáčková
UNLABELLED: The differential diagnosis of hyponatremia is often difficult. This most frequently occurring disorder of the water and electrolyte metabolism is frequently connected with deviations relating to the acid-base balance (ABB). This survey analyzes the relationship between the changes of the volume of body fluids and ABB and infers to what extent the analysis of combinations of the two disorders can support the differential diagnosis of different forms of hyponatremia (differentiation between the dilution vs...
2016: Vnitr̆ní Lékar̆ství
Ivan Hiltpold, Ben D Moore, Scott N Johnson
Optimizing plant protection against insect herbivory relies on testing plant defense mechanisms and how the insect response to these defensive strategies. Such experiments benefit from using insects generated from standardized rearing protocols since this reduces stochastic variation. Such protocols can be challenging to devise, however, especially for root herbivores. These insects generally have complex and long life cycles, which are often only poorly described. Moreover, using field-captured root herbivores is often suboptimal because it involves extensive excavation from sites selected by chance (their location is not obvious) and larval stages are frequently indistinguishable beyond the family level...
2016: Frontiers in Plant Science
Wenjing Cui, Feng Song, Feifei Song, Dandan Ju, Shujing Liu
Here we propose a new method for trapping the resonant metallic particles with the 4π tight focusing (high numerical-aperture (NA)) system, which is illuminated by radial polarization light. Numerical simulations have indicated the maximum total optical force is 16.1pN while with nearly zero scattering force under axis trapping, which keeps the gradient force predominant. Furthermore, the distribution of total force is centrosymmetric and odd. We also gain stable 3D trap with an equilibrium point along z axis and r axis as in normal optical tweezers...
September 5, 2016: Optics Express
Muhammad Sohail, Muhammad Mustehsan Bashir, Hamid Hussain Ansari, Farid Ahmad Khan, Noreen Assumame, Nukhbat Ullah Awan, Asad Aizaz Chatha
OBJECTIVES: To describe the characteristics and outcome of management of vascular malformations of lip. PLACE AND DURATION OF STUDY: The Department of Plastic Surgery and Burn Unit, King Edward Medical University, Mayo Hospital, Lahore, from January 2009 to December 2013. METHODS: A prospective case series of 38 patients with vascular malformation of lip was performed. Demographic information and clinical features were noted. Treatment employed, complications, functional, and cosmetic outcome were recorded...
September 2016: Journal of Craniofacial Surgery
Ahlem Mansouri, Mickael Cregut, Chiraz Abbes, Marie-Jose Durand, Ahmed Landoulsi, Gerald Thouand
DDT (1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane) is probably the best known and most useful organochlorine insecticide in the world which was used since 1945 for agricultural purposes and also for vector-borne disease control such as malaria since 1955, until its banishment in most countries by the Stockholm convention for ecologic considerations. However, the World Health Organization allowed its reintroduction only for control of vector-borne diseases in some tropical countries in 2006. Due to its physicochemical properties and specially its persistence related with a half-life up to 30 years, DDT linked to several health and social problems which are due to its accumulation in the environment and its biomagnification properties in living organisms...
September 3, 2016: Applied Biochemistry and Biotechnology
Shoumin Zhu, Mohammed Soutto, Zheng Chen, DunFa Peng, Judith Romero-Gallo, Uma S Krishna, Abbes Belkhiri, M Kay Washington, Richard Peek, Wael El-Rifai
OBJECTIVE: DARPP-32 is a frequently amplified and overexpressed gene that promotes several oncogenic functions in gastric cancer. Herein, we investigated the relationship between Helicobacter pylori infection, proinflammatory NF-κB activation and regulation of DARPP-32. DESIGN: The study used in vivo and in vitro experiments. Luciferase reporter, quantitative real-time PCR, immunoblot, chromatin immunoprecipitation (ChIP), cell viability, H. pylori infection, tissue microarrays and immunohistochemical assays were used...
September 2, 2016: Gut
J Sardos, X Perrier, J Doležel, E Hřibová, P Christelová, I Van den Houwe, A Kilian, N Roux
BACKGROUND AND AIMS: Dessert and cooking bananas are vegetatively propagated crops of great importance for both the subsistence and the livelihood of people in developing countries. A wide diversity of diploid and triploid cultivars including AA, AB, AS, AT, AAA, AAB, ABB, AAS and AAT genomic constitutions exists. Within each of this genome groups, cultivars are classified into subgroups that are reported to correspond to varieties clonally derived from each other after a single sexual event...
September 1, 2016: Annals of Botany
Shaokai Wang, Jiwen Cui, Jiubin Tan, Yongmeng Liu
In order to further improve the linear datum based geometric measurement accuracy and expand the measurement range, a 6-DoF motion system is developed for realizing a linear datum in the form of motion trajectory of the contact point (CP) of an absolute displacement measurement probe. This linear datum is established based on the concept of coordinate measurement and it does not contain straightness error in theory. The 6-DoF motion system consists of a 6-DoF fine stage and a 1-DoF coarse stage. The probe is moved by the 6-DoF fine stage which is magnetically noncontact supported and parallelly noncontact actuated...
August 2016: Review of Scientific Instruments
Antoine Millet, Magali Plaisant, Cyril Ronco, Michaël Cerezo, Patricia Abbe, Emilie Jaune, Elisa Cavazza, Stéphane Rocchi, Rachid Benhida
Cancer is the second cause of deaths worldwide and is forecasted to affect more that 22 million people in 2020. Despite dramatic improvement in its care over the last two decades, the treatment of resistant forms of cancer is still an unmet challenge. Thus, innovative and efficient treatments are still needed. In this context, we report herein the synthesis and the evaluation of a new class of bioactive molecules belonging to the N-(4-(3-aminophenyl(thiazol-2-yl)acetamide family. Structure-activity relationships could be driven and resulted in the discovery of lead compound 6b...
September 22, 2016: Journal of Medicinal Chemistry
Dirk Hölscher, Andreas Buerkert, Bernd Schneider
Phenylphenalenone-type compounds accumulated in the tissues of two banana cultivars-Musa acuminata cv. "Grande Naine" (AAA) and Musa acuminata × balbisiana Colla cv. "Bluggoe" (ABB)-when these were fed on by the banana weevil (Cosmopolites sordidus (Germ.) (Coleoptera: Curculionidae)) and the banana stem weevil (Odoiporus longicollis (Oliver) (Coleoptera: Curculionidae)). The chemical constituents of the banana material were separated by means of chromatographic techniques and identified by NMR spectroscopy...
August 25, 2016: Plants (Basel, Switzerland)
Sangeeta Saikia, Charu Lata Mahanta
A comparative study was done on the health promoting and functional properties of the fibers obtained as by-products from six fruits viz., pomace of carambola (Averrhoa carambola L.) and pineapple (Ananas comosus L. Merr), peels of watermelon (Citrullus lanatus), Burmese grape (Baccurea sapida Muell. Arg) and Khasi mandarin orange (Citrus reticulata Blanco), and blossom of seeded banana (Musa balbisiana, ABB). Highest yield of fiber was obtained from Burmese grape peel (BGPL, 79.94 ± 0.41 g/100 g) and seeded banana blossom (BB 77...
March 2016: Journal of Food Science and Technology
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