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https://www.readbyqxmd.com/read/28417568/cisplatin-resistant-cancer-cells-are-sensitive-to-aurora-kinase-a-inhibition-by-alisertib
#1
Lihong Wang, Janet Arras, Ahmed Katsha, Saif Hamdan, Abbes Belkhiri, Jeffrey Ecsedy, Wael El-Rifai
De novo and acquired resistance to platinum therapy such as cisplatin (CDDP) is a clinical challenge in gastric cancer treatment. Aberrant expression and activation of Aurora kinase A (AURKA) and eukaryotic translation initiation factor 4E (eIF4E) are detected in several cancer types. Herein, we investigated the role of AURKA in CDDP resistance in gastric cancer. Western blot analysis demonstrated overexpression of AURKA and phosphorylation of eIF4E in acquired and de novo CDDP-resistant gastric cancer models...
April 18, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28412602/secondary-outcomes-from-the-pediatric-obsessive-compulsive-disorder-treatment-study-ii
#2
Christine A Conelea, Robert R Selles, Kristen G Benito, Michael M Walther, Jason T Machan, Abbe M Garcia, Jeffrey Sapyta, Sarah Morris, Martin Franklin, Jennifer B Freeman
The Pediatric Obsessive-Compulsive Disorder Treatment Study II (POTS II) investigated the benefit of serotonin reuptake inhibitor (SRI) augmentation with cognitive behavioral therapy (CBT). Primary outcomes focused on OCD symptom change and indicated benefit associated with a full course of CBT. Given that the majority of youth with OCD suffer from significant comorbid symptoms and impaired quality of life, the current study examined POTS II data for effects on secondary outcomes. Participants were 124 youth ages 7-17 years with a primary diagnosis of OCD who were partial responders to an adequate SRI trial...
April 7, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28392650/transoral-cross-lip-abb%C3%A3-estlander-flap-as-a-viable-and-effective-reconstructive-option-in-middle-lower-lip-defect-reconstruction
#3
Hyung Jin Hahn, Hyun Jee Kim, Jin Young Choi, Soo Young Lee, Young Bok Lee, Jin Wou Kim, Dong Soo Yu
The Abbé-Estlander flap surgery is a cross-lip procedure that is valuable in repairing a defect on the lower lip using a full-thickness flap, consisting of the skin, muscle and mucosa, from the upper lip. As usefulness and practicality of the flap in reconstruction of lower lip surgical defects in Asian ethnicity have not been documented, the authors present a case of successful lower lip reconstruction with a staged, Abbé-Estlander lip switching flap with commissuroplasty as an illustrative example. A 71-year-old male has presented with an ulcerating lip nodule in the middle one third of the lower lip, measuring about 1...
April 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28379687/kinetic-requirements-for-spatiotemporal-chemical-imaging-with-fluorescent-nanosensors
#4
Daniel Meyer, Annika Hagemann, Sebastian Kruss
Fluorescent nanosensors are powerful tools for basic research and bioanalytical applications. Individual nanosensors are able to detect single molecules, while ensembles of nanosensors can be used to measure the bulk concentration of an analyte. Collective imaging of multiple nanosensors could provide both spatial and temporal chemical information from the nano- to the microscale. This type of chemical imaging with nanosensors would be very attractive to study processes such as chemical signaling between cells (e...
April 10, 2017: ACS Nano
https://www.readbyqxmd.com/read/28372910/structure-activity-relationship-and-optimization-of-n-3-2-aminothiazol-4-yl-aryl-benzenesulfonamides-as-anti-cancer-compounds-against-sensitive-and-resistant-cells
#5
Cyril Ronco, Antoine Millet, Magali Plaisant, Patricia Abbe, Nedra Hamouda-Tekaya, Stéphane Rocchi, Rachid Benhida
We recently described a new family of bioactive molecules with interesting anti-cancer activities: the N-(4-(3-aminophenyl)thiazol-2-yl)acetamides. The lead compound of the series (1) displays significant anti-proliferative and cytotoxic activities against a panel of cancer cell lines, either sensitive or resistant to standard treatments. This molecule also shows a good pharmacological profile and high in vivo potency towards mice xenografts, without signs of toxicity on the animals. In the present article, we disclose the structure-activity relationships of this lead compound, which have provided clear information about the replacement of the acetamide function and the substitution pattern of the benzenesulfonamide ring...
March 23, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28370111/the-addition-effect-of-tunisian-date-seed-fibers-on-the-quality-of-chocolate-spreads
#6
Mohamed Ali Bouaziz, Fatma Abbes, Abir Mokni, Christophe Blecker, Hamadi Attia, Souhail Besbes
Novel chocolate spreads were enriched by soluble and insoluble dietary fibers from Tunisian Deglet Nour date seeds at 1, 2, 3, 4, and 5% levels in the conventional chocolate spread. Defatted Deglet Nour date seeds, date seed soluble fiber concentrate (DSSFC) and date seed insoluble fiber concentrate (DSIFC) were characterized by high levels of dietary fibers (80-90%). Chocolate spread enriched with 5% of DSSFC presented the highest oil binding capacity (304.62%) compared to the control (102%). Whatever the DSIFC and DSSFC incorporation levels, no significant difference was recorded between the firmness, chewiness, and adhesiveness of prepared chocolate spreads compared to the control (p < ...
April 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28359810/an-approach-for-chemical-stability-during-melt-extrusion-of-a-drug-substance-with-a-high-melting-point
#7
Abbe Haser, Siyuan Huang, Tony Listro, David White, Feng Zhang
Poorly water-soluble drug substances that exhibit high melting points are difficult to process by melt extrusion due to chemical instability at high temperatures required for processing. The purpose of this study was to extrude meloxicam (melting point 255°C) by optimizing processing parameters and formulation composition. Five extrusion studies were performed: 1) design space, 2) impact of moisture, 3) impact of melt residence time, 4) specific energy optimization, and 5) altered microenvironment pH. Powder X-ray diffraction and polarized light microscopy were used to confirm amorphous conversion...
March 28, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28323561/immobilization-of-asiatic-black-bears-ursus-thibetanus-with-medetomidine-zolazepam-tiletamine-in-south-korea
#8
Dong-Hyuk Jeong, Jeong-Jin Yang, Seong-Hoon Seok, Byeung-Cheul Song, Seong-Chan Yeon
The Asiatic black bear ( Ursus thibetanus ; ABB) is a globally endangered species for which a restoration program has been ongoing in South Korea since 2001. However, there is little information on immobilization protocols for ABBs. We evaluated the use of medetomidine-zolazepam-tiletamine for their immobilization. During 2005-2013, we anesthetized 60 ABBs (32 males, 28 females; 7 mo to 12 yr old) with medetomidine 0.03-0.045 mg/kg and zolazepam-tiletamine 1.54-2.3 mg/kg; reversal of anesthesia was done with atipamezole 0...
March 21, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28315285/effects-of-plyometric-training-on-physical-fitness-in-prepuberal-soccer-athletes
#9
Yassine Negra, Helmi Chaabene, Senda Sammoud, Raja Bouguezzi, Mohamed Aymen Abbes, Younés Hachana, Urs Granacher
This study aimed at examining the effects of plyometric training on stable (SPT) vs. unstable (UPT) surfaces on physical fitness in prepuberal soccer players. Male athletes were randomly assigned to SPT (n=18; age=12.7±0.2 years) or UPT (n=16; age=12.2±0.5 years). Both groups conducted 3 regular soccer training sessions per week combined with either 2 SPT or UPT sessions. Assessment of jumping ability (countermovement jump [CMJ], and standing long jump [SLJ]), speed (10-m, 20-m, 30-m sprint), agility (Illinois agility test [IAT]), and balance (stable [SSBT], unstable [USBT] stork balance test; stable [SYBT], unstable [UYBT] Y balance test) was conducted pre-and post-training...
March 17, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28291857/effect-of-maxillary-sinus-membrane-perforation-on-implant-survival-rate-a-retrospective-study
#10
Carlos Eduardo de Almeida Ferreira, Carolina Borges Martinelli, Arthur Belém Novaes, Túlio Bonna Pignaton, Camila Coser Guignone, Adriana Luísa Gonçalves de Almeida, Eduardo Saba-Chujfi
PURPOSE: The aim of this retrospective study was to evaluate implant survival rates (ISRs) for implants placed in grafted sinuses where a membrane perforation occurred during augmentation using exclusively anorganic bovine bone (ABB) by means of clinical and radiographic examinations. Histologic information of five biopsy specimens taken from large membrane perforations is also presented. MATERIALS AND METHODS: Consecutive patients who underwent sinus augmentation procedures at a private practice Dental Institute between 2004 and 2013 were collected from a computer database...
March 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28286932/hoct1-gene-expression-predict-for-optimal-response-to-imatinib-in-tunisian-patients-with-chronic-myeloid-leukemia
#11
Islem Ben Hassine, Hanene Gharbi, Ismail Soltani, Mouheb Teber, Ahlem Farrah, Hind Ben Hadj Othman, Hassiba Amouri, Hatem Bellaaj, Rayhane Ben Lakhal, Neila Ben Romdhane, Salem Abbes, Samia Menif
PURPOSE: Imatinib mesylate (IM) is considered as a highly effective therapy for chronic myeloid leukemia (CML) patients. However, a minority of patients fail to achieve optimal response due to impaired bioavailability of IM. The human organic cation transporter 1 (OCT1; SLC22A1) has been reported to be the main influx transporter involved in IM uptake into CML cells. Genetic variants and/or hOCT1 expression changes may influence IM response. In this study, we aimed to investigate the impact of both hOCT1 polymorphisms located in exon 7 and hOCT1 mRNA levels on the clinical outcome in CML patients...
March 12, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28281364/chemical-composition-antioxidant-and-antibacterial-activities-of-tamarix-balansae-j-gay-aerial-parts
#12
Abbes Benmerache, Mounira Benteldjoune, Abdulmagid Alabdul Magid, Amin Abedini, Djemaa Berrehal, Ahmed Kabouche, Sophie C Gangloff, Laurence Voutquenne-Nazabadioko, Zahia Kabouche
A previously undescribed phenolic sulphate ester, potassium 34-dihydroxy-3-methoxybenzoic acid methyl ester-5-sulphate (1), along with nine known flavonoids, kaempferol-3-O-potassium sulphate-4',7-dimethyl ether (2), kaempferol-4',7-dimethyl ether (3), rhamnocitrin-3-O-potassium sulphate (4), rhamnocitrin (5), kaempferol (6), quercetin (7), afzelin (8), quercetin-3-O-α-l-rhamnopyranoside (9) and luteolin-3'-O-potassium sulphate (10) were isolated from the aerial parts of Tamarix balansae. Structures elucidation was performed by comprehensive 1D and 2D NMR analyses, mass spectrometry and by comparison with literature data...
March 10, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28277720/artificial-grammar-learning-in-tamarins-saguinus-oedipus-in-varying-stimulus-contexts
#13
Julie J Neiworth, Justin M London, Michael J Flynn, Deborah D Rupert, Owen Alldritt, Caleb Hyde
The human ability to detect regularities in sound sequences is a fundamental substrate of our language faculty. However, is this an ability exclusive to human language processing, or have we usurped a more general learning mechanism for this purpose, one shared with other species? The current study is an attempt to replicate and extend Hauser, Weiss, and Marcus's (2002) retracted study (2010) of artificial grammar learning in tamarins to determine if tamarins can detect an underlying grammatical structure in a pattern of sounds...
March 9, 2017: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/28259831/melt-extrusion-vs-spray-drying-the-effect-of-processing-methods-on-crystalline-content-of-naproxen-povidone-formulations
#14
Abbe Haser, Tu Cao, Joe Lubach, Tony Listro, Larry Acquarulo, Feng Zhang
Our hypothesis is that melt extrusion is a more suitable processing method than spray drying to prepare amorphous solid dispersions of drugs with a high crystallization tendency. Naproxen-povidone K25 was used as the model system in this study. Naproxen-povidone K25 solid dispersions at 30% and 60% drug loadings were characterized by modulated DSC, powder X-ray diffraction, FT-IR, and solid-state (13)C NMR to identify phase separation and drug recrystallization during processing and storage. At 30% drug loading, hydrogen bond (H-bond) sites of povidone K25 were not saturated and the glass transition (Tg) temperature of the formulation was higher...
March 1, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28248424/image-scanning-microscopy-an-overview
#15
E N Ward, R Pal
For almost a century, the resolution of optical microscopy was thought to be limited by Abbé's law describing the diffraction limit of light. At the turn of the millennium, aided by new technologies and fluorophores, the field of optical microscopy finally surpassed the diffraction barrier: a milestone achievement that has been recognized by the 2014 Nobel Prize in Chemistry. Many super-resolution methods rely on the unique photophysical properties of the fluorophores to improve resolution, posing significant limitations on biological imaging, such as multicoloured staining, live-cell imaging and imaging thick specimens...
March 1, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28243449/performance-of-the-freestyle-libre-flash-glucose-monitoring-system-in-patients-with-type-1-and-2-diabetes-mellitus
#16
M J Fokkert, P R van Dijk, M A Edens, S Abbes, D de Jong, R J Slingerland, H J G Bilo
OBJECTIVE: To evaluate the performance of the FreeStyle Libre Flash continuous glucose monitoring (FSL-CGM) system against established central laboratory methods. RESEARCH DESIGN AND METHODS: 20 subjects (8 type 1 diabetes mellitus, 12 type 2 diabetes mellitus) were analyzed. FSL-CGM sensor measurements (inserted in arm and abdomen) were compared with capillary blood glucose results analyzed with StatStrip as semigold standard. The glucose response after a standardized oral glucose load was measured by FSL-CGM and capillary samples analyzed by perchloric acid hexokinase (PCA-HK) method, StatStrip and FSL test strip (FSLC), and a commonly used CGM system (iPro2)...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28242938/effect-of-extraction-condition-on-properties-of-pectin-from-banana-peels-and-its-function-as-fat-replacer-in-salad-cream
#17
Nitjaree Maneerat, Nattapol Tangsuphoom, Anadi Nitithamyong
Banana peels are wasted from banana processing industry. Pectin is a soluble dietary fibre usually prepared from fruit and vegetable processing wastes. Pectin extraction from banana peels thus should be an effective way of waste utilization. This study aimed to determine the effect of extraction condition on the properties of pectin from peels of Nam Wa banana (Musa (ABB group) 'Kluai Nam Wa') and its role as fat replacer in salad cream. Banana peel pectin (BPP) was extracted with HCl (pH 1.5) and water (pH 6...
February 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28234527/process-accessible-states-of-block-copolymers
#18
De-Wen Sun, Marcus Müller
Process-directed self-assembly of block copolymers refers to thermodynamic processes that reproducibly direct the kinetics of structure formation from a starting, unstable state into a selected, metastable mesostructure. We investigate the kinetics of self-assembly of linear ACB triblock copolymers after a rapid transformation of the middle C block from B to A. This prototypical process (e.g., photochemical transformation) converts the initial, equilibrium mesophase of the ABB copolymer into a well-defined but unstable, starting state of the AAB copolymer...
February 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28232218/different-erp-profiles-for-learning-rules-over-consonants-and-vowels
#19
Júlia Monte-Ordoño, Juan M Toro
The Consonant-Vowel hypothesis suggests that consonants and vowels tend to be used differently during language processing. In this study we explored whether these functional differences trigger different neural responses in a rule learning task. We recorded ERPs while nonsense words were presented in an Oddball paradigm. An ABB rule was implemented either over the consonants (Consonant condition) or over the vowels (Vowel condition) composing standard words. Deviant stimuli were composed by novel phonemes. Deviants could either implement the same ABB rule as standards (Phoneme deviants) or implement a different ABA rule (Rule deviants)...
February 20, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28223034/children-s-head-motion-during-fmri-tasks-is-heritable-and-stable-over-time
#20
Laura E Engelhardt, Mary Abbe Roe, Jenifer Juranek, Dana DeMaster, K Paige Harden, Elliot M Tucker-Drob, Jessica A Church
Head motion during fMRI scans negatively impacts data quality, and as post-acquisition techniques for addressing motion become increasingly stringent, data retention decreases. Studies conducted with adult participants suggest that movement acts as a relatively stable, heritable phenotype that serves as a marker for other genetically influenced phenotypes. Whether these patterns extend downward to childhood has critical implications for the interpretation and generalizability of fMRI data acquired from children...
February 1, 2017: Developmental Cognitive Neuroscience
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