keyword
https://read.qxmd.com/read/38296648/taranis-interacts-with-vrille-and-pdp1-to-modulate-the-circadian-transcriptional-feedback-mechanism-in-drosophila
#21
JOURNAL ARTICLE
Oghenerukevwe Akpoghiran, Dinis J S Afonso, Yanan Zhang, Kyunghee Koh
The molecular clock that generates daily rhythms of behavior and physiology consists of interlocked transcription-translation feedback loops. In Drosophila , the primary feedback loop involving the CLOCK-CYCLE transcriptional activators and the PERIOD-TIMELESS transcriptional repressors is interlocked with a secondary loop involving VRILLE (VRI) and PAR DOMAIN PROTEIN 1 (PDP1), a repressor and activator of Clock transcription, respectively. Whereas extensive studies have found numerous transcriptional, translational, and posttranslational modulators of the primary loop, relatively little is known about the secondary loop...
January 31, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38294880/dissecting-the-interaction-between-cryptochrome-and-timeless-reveals-underpinnings-of-light-dependent-recognition
#22
JOURNAL ARTICLE
Connor M Schneps, Robert Dunleavy, Brian R Crane
Circadian rhythms are determined by cell-autonomous transcription-translation feedback loops that entrain to environmental stimuli. In the model circadian clock of Drosophila melanogaster , the clock is set by the light-induced degradation of the core oscillator protein timeless (TIM) by the principal light-sensor cryptochrome (CRY). The cryo-EM structure of CRY bound to TIM revealed that within the extensive CRY:TIM interface, the TIM N-terminus binds into the CRY FAD pocket, in which FAD and the associated phosphate-binding loop (PBL) undergo substantial rearrangement...
January 31, 2024: Biochemistry
https://read.qxmd.com/read/38287057/light-pollution-disrupts-circadian-clock-gene-expression-in-two-mosquito-vectors-during-their-overwintering-dormancy
#23
JOURNAL ARTICLE
Lydia R Fyie, Katie M Westby, Megan E Meuti
Artificial light at night (ALAN) is an increasingly important form of environmental disturbance as it alters Light:Dark cycles that regulate daily and seasonal changes in physiology and phenology. The Northern house mosquito (Culex pipiens) and the tiger mosquito (Aedes albopictus) enter an overwintering dormancy known as diapause that is cued by short days. These two species differ in diapause strategy: Cx. pipiens diapause as adult females while Ae. albopictus enter a maternally-programmed, egg diapause. Previous studies found that ALAN inhibits diapause in both species, but the mechanism is unknown...
January 29, 2024: Scientific Reports
https://read.qxmd.com/read/38261568/ncrnas-mediated-timeless-overexpression-in-lung-adenocarcinoma-correlates-with-reduced-tumor-immune-cell-infiltration-and-poor-prognosis
#24
JOURNAL ARTICLE
Xinliang Gao, Mingbo Tang, Suyan Tian, Jialin Li, Shixiong Wei, Shucheng Hua, Wei Liu
Lung adenocarcinoma (LUAD) has a poor prognosis. Circadian genes such as TIMELESS have been associated with several pathologies, including cancer. The expression of TIMELESS and the relationship between TIMELESS, infiltration of tumors and prognosis in LUAD requires further investigation. In this study, we investigated the expression of TIMELESS and its association with survival across several types of human cancer using data from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression Program. Noncoding RNAs (ncRNAs) regulating overexpression of TIMELESS in lung adenocarcinoma (LUAD) were explored with expression, correlation, and survival analyses...
2024: PloS One
https://read.qxmd.com/read/38211843/hmgb1-mediated-transcriptional-activation-of-circadian-gene-timeless-contributes-to-endometrial-cancer-progression-through-wnt-%C3%AE-catenin-pathway
#25
JOURNAL ARTICLE
Zhaoxia Wang, Simin He, Liqing Xin, Ying Zhou, Le Zhao, Fuyuan Wang
TIMELESS (TIM) is a circadian gene which is implicated in the regulation of daily rhythm, DNA replication and repair, and cancer initiation and progression. Nevertheless, the role of TIM in endometrial cancer (EC) development is largely unknown. Bioinformatics analysis showed that TIM was aberrantly up-regulated in EC tissues and positively correlated with clinical or histological grade of EC. Functional studies showed that TIM knockdown reduced EC cell viability and restrained EC cell migration in vitro, as well as blocked xenograft tumor growth in vivo...
January 9, 2024: Cellular Signalling
https://read.qxmd.com/read/38178094/timeless-promotes-reprogramming-of-glucose-metabolism-in-oral-squamous-cell-carcinoma
#26
JOURNAL ARTICLE
Yafan Chen, Zhengyang Han, Le Zhang, Caihong Gao, Jingyi Wei, Xuyuan Yang, Yabing Han, Yunbo Li, Chunmei Zhang, Yixin Wei, Jiaqi Dong, Wenxing Xun, Weifu Sun, Taotao Zhang, Hui Zhang, Jingtao Chen, Peng Yuan
BACKGROUND: Oral squamous cell carcinoma (OSCC), the predominant malignancy of the oral cavity, is characterized by high incidence and low survival rates. Emerging evidence suggests a link between circadian rhythm disruptions and cancer development. The circadian gene TIMELESS, known for its specific expression in various tumors, has not been extensively studied in the context of OSCC. This study aims to explore the influence of TIMELESS on OSCC, focusing on cell growth and metabolic alterations...
January 4, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38146331/dozing-off-with-drosophila-the-effect-of-disrupted-circadian-rhythms-and-sleep-disturbance-on-mortality-mood-and-addiction
#27
JOURNAL ARTICLE
Rania S Lateef, Bibhaw Pokharel, Tasnuva Nuhat Shafin
Many environmental factors can disrupt sleep and circadian rhythms, yet the consequences of such disruptions are poorly understood. The main goals of this project were to study the effects of disrupted circadian rhythms and sleep disturbance on Drosophila melanogaster's : (1) lifespan, (2) depression-like behaviors, and (3) propensity to consume caffeine-containing media. Three experimental groups were used: controls, Circadian Dysfunction (CD), and Sleep Disturbance (SD). Circadian disruption (CD): used flies with Tim 01 mutation, which eliminates circadian behavioral rhythms...
2023: Neuroscience insights
https://read.qxmd.com/read/38140619/evolving-horizons-adenovirus-vectors-timeless-influence-on-cancer-gene-therapy-and-vaccines
#28
REVIEW
Prasad D Trivedi, Barry J Byrne, Manuela Corti
Efficient and targeted delivery of a DNA payload is vital for developing safe gene therapy. Owing to the recent success of commercial oncolytic vector and multiple COVID-19 vaccines, adenovirus vectors are back in the spotlight. Adenovirus vectors can be used in gene therapy by altering the wild-type virus and making it replication-defective; specific viral genes can be removed and replaced with a segment that holds a therapeutic gene, and this vector can be used as delivery vehicle for tissue specific gene delivery...
December 3, 2023: Viruses
https://read.qxmd.com/read/38089472/mir-277-regulates-the-phase-of-circadian-activity-rest-rhythm-in-drosophila-melanogaster
#29
JOURNAL ARTICLE
Geo Anna, Maria John, Nisha N Kannan
Circadian clocks temporally organize behaviour and physiology of organisms with a rhythmicity of about 24 h. In Drosophila , the circadian clock is composed of mainly four clock genes: period ( per ) , timeless ( tim ) , Clock ( Clk ) and cycle ( cyc ) which constitutes the transcription-translation feedback loop. The circadian clock is further regulated via post-transcriptional and post-translational mechanisms among which microRNAs (miRNAs) are well known post-transcriptional regulatory molecules. Here, we identified and characterized the role of miRNA-277 (miR-277) expressed in the clock neurons in regulating the circadian rhythm...
2023: Frontiers in Physiology
https://read.qxmd.com/read/38076905/taranis-interacts-with-vrille-and-pdp1-to-modulate-the-circadian-transcriptional-feedback-mechanism-in-drosophila
#30
Oghenerukevwe Akpoghiran, Dinis J S Afonso, Yanan Zhang, Kyunghee Koh
UNLABELLED: The molecular clock that generates daily rhythms of behavior and physiology consists of interlocked transcription-translation feedback loops. In Drosophila , the primary feedback loop involving the CLOCK-CYCLE transcriptional activators and the PERIOD-TIMELESS transcriptional repressors is interlocked with a secondary loop involving VRILLE (VRI) and PAR DOMAIN PROTEIN 1 (PDP1), a repressor and activator of Clock transcription, respectively. Whereas extensive studies have found numerous transcriptional, translational, and post-translational modulators of the primary loop, relatively little is known about the secondary loop...
May 21, 2023: bioRxiv
https://read.qxmd.com/read/38058384/cardiac-timeless-trans-organically-regulated-by-mir-276-in-adipose-tissue-modulates-cardiac-function
#31
JOURNAL ARTICLE
Chao Tang, Qiufang Li, Xiaoya Wang, Zhengwen Yu, Xu Ping, Yi Qin, Yang Liu, Lan Zheng
The interconnection between cardiac function and circadian rhythms is of great importance. While the role of the biological clock gene Timeless (Tim) in circadian rhythm has been extensively studied, its impact on cardiac function remains largely been unexplored. Previous research has provided experimental evidence for the regulation of the heart by adipose tissue and the targeting of miR-276a/b on Timeless. However, the extent to which adipose tissue regulates cardiac Timeless genes trans-organically through miR-276a/b, and subsequently affects cardiac function, remains uncertain...
2024: Function
https://read.qxmd.com/read/38053143/an-integrative-evaluation-of-circadian-gene-timeless-as-a-pan-cancer-immunological-and-predictive-biomarker
#32
JOURNAL ARTICLE
Yaocheng Yang, Xianzhe Tang, Zhengjun Lin, Tao Zheng, Sheng Zhang, Tang Liu, Xiaolun Yang
BACKGROUND: The gene TIMELESS, which is involved in the circadian clock and the cell cycle, has recently been linked to various human cancers. Nevertheless, the association between TIMELESS expression and the prognosis of individuals afflicted with pan-cancer remains largely unknown. OBJECTIVES: The present study aims to exhaustively scrutinize the expression patterns, functional attributes, prognostic implications, and immunological contributions of TIMELESS across diverse types of human cancer...
December 5, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37969365/a-circadian-clock-gene-related-signature-for-predicting-prognosis-and-its-association-with-sorafenib-response-in-hepatocellular-carcinoma
#33
JOURNAL ARTICLE
Qing Liang, Yongqing Ye, Enze Li, Jingming Fan, Jinglin Gong, Jiaxin Ying, Yawen Cao, Rongqi Li, Ping Wang
BACKGROUND: Hepatocellular carcinoma (HCC), one of the highest causes of cancer-associated death, has effective treatments, especially for patients with advanced HCC. Circadian rhythm participates in several important physiological functions, and its chronic disruption results in many disordered diseases, including cancer. However, the role of circadian rhythm in the overall survival (OS) of patients with HCC remains unclear. METHODS: We investigated the expression, copy number variation (CNV), and mutation profiles of core circadian clock genes in normal and tumor tissues...
October 31, 2023: Translational Cancer Research
https://read.qxmd.com/read/37924048/six-hour-time-restricted-feeding-inhibits-lung-cancer-progression-and-reshapes-circadian-metabolism
#34
JOURNAL ARTICLE
Dan Shi, Gaofeng Fang, Qianyao Chen, Jianling Li, Xiongzhong Ruan, Xuemei Lian
BACKGROUND: Accumulating evidence has suggested an oncogenic effect of diurnal disruption on cancer progression. To test whether targeting circadian rhythm by dietary strategy suppressed lung cancer progression, we adopted 6-h time-restricted feeding (TRF) paradigm to elucidate whether and how TRF impacts lung cancer progression. METHODS: This study used multiple lung cancer cell lines, two xenograft mouse models, and a chemical-treated mouse lung cancer model. Stable TIM-knockdown and TIM-overexpressing A549 cells were constructed...
November 3, 2023: BMC Medicine
https://read.qxmd.com/read/37923872/relationship-between-circadian-rhythm-related-genes-and-extracellular-matrix-implications-for-sleep-deprivation
#35
JOURNAL ARTICLE
Xuejuan Liu, Jia Sun, Zexia Ling, Tong Dong
BACKGROUND: Sleep deprivation (SD) can lead to the development of various pathological disorders. The extracellular matrix (ECM) compositions and circadian rhythm genes are two pivotal variables of SD. However, their relationships remain undefined during SD. METHODS: A mouse SD model was established using a modified multiplatform water environment method. The expression of nerve growth factor (NGF) in mouse hippocampus was detected by an immunofluorescence (IF) method...
November 4, 2023: Sleep & Breathing
https://read.qxmd.com/read/37917075/germline-editing-of-drosophila-using-crispr-cas9-based-cytosine-and-adenine-base-editors
#36
JOURNAL ARTICLE
Nirav Thakkar, Adela Hejzlarova, Vaclav Brabec, David Dolezel
Target-AID, BE3, and ABE7.10 base editors fused to the catalytically modified Cas9 and xCas9(3.7) were tested for germline editing of the fruit fly Drosophila melanogaster . We developed a guide RNA-expressing construct, white- 4gRNA, targeting splice sites in the white gene, an X-chromosome located gene. Using white- 4gRNA flies and transgenic lines expressing Target-AID, BE3, and ABE7.10 base editors, we tested the efficiency of stable germline gene editing at three different temperatures. Classical Cas9 generating insertions/deletions by non-homologous end joining served as a reference...
November 2, 2023: CRISPR Journal
https://read.qxmd.com/read/37907175/silencing-the-rhythm-gene-agclk-1-reduced-feeding-of-aphis-gossypii
#37
JOURNAL ARTICLE
Weijiao Liu, Qiqing Yu, Chuanpeng Wang, Xiangzhen Zhu, Li Wang, Kaixin Zhang, Dongyang Li, Jichao Ji, Junyu Luo, Jinjie Cui, Xueke Gao
The cotton aphid Aphis gossypii Glover is an important cotton pest, and means of controlling this insect is a primary research focus. Although biological rhythm is an important mechanism that regulates numerous insect processes and activities, its role in cotton aphid has not been elucidated. In the present study, four highly-expressed circadian rhythm genes were selected from the cotton aphid genome database and their physicochemical properties and protein structures were analyzed. These genes were in the Takeout, Timeless, and Timeless interacting-related families, and the corresponding proteins contained highly-conserved Swis and TIMELESS domains...
October 29, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37856540/the-circadian-clock-gene-bmal1-is-necessary-for-co-ordinated-circatidal-rhythms-in-the-marine-isopod-eurydice-pulchra-leach
#38
JOURNAL ARTICLE
Zhang Lin, Edward W Green, Simon G Webster, Michael H Hastings, David C Wilcockson, Charalambos P Kyriacou
Circadian clocks in terrestrial animals are encoded by molecular feedback loops involving the negative regulators PERIOD, TIMELESS or CRYPTOCHROME2 and positive transcription factors CLOCK and BMAL1/CYCLE. The molecular basis of circatidal (~12.4 hour) or other lunar-mediated cycles (~15 day, ~29 day), widely expressed in coastal organisms, is unknown. Disrupting circadian clockworks does not appear to affect lunar-based rhythms in several organisms that inhabit the shoreline suggesting a molecular independence of the two cycles...
October 2023: PLoS Genetics
https://read.qxmd.com/read/37827695/modified-ipond-revealed-the-role-of-mutant-p53-in-promoting-helicase-function-and-telomere-maintenance
#39
JOURNAL ARTICLE
Qianqian Wang, Kailong Hou, Jun Yang, Haili Li, Cui Li, Yanduo Zhang, Jie Tian, Chuanbiao Li, Bing Guo, Shuting Jia, Ying Luo
The G-rich DNA, such as telomere, tends to form G-quadruplex (G4) structure, which slows down the replication fork progression, induces replication stress, and becomes the chromosome fragile sites. Here we described a molecular strategy that cells developed to overcome the DNA replication stress via DNA helicase regulation. The p53N236S (p53S) mutation has been found in the Werner syndrome mouse embryo fibroblast (MEFs) escaped from senescence, could be the driving force for cell escaping senescence. We revealed that the p53S could transcriptionally up-regulate DNA helicases expression, including Wrn, Blm, Timeless, Ddx, Mcm, Gins, Fanc, as well as telomere specific proteins Terf1, Pot1, through which p53S promoted the unwinding of G4 structures, and protected the cells from DNA replication stress induced by G4 stabilizer...
October 12, 2023: Aging
https://read.qxmd.com/read/37805193/the-lancet-at-200-years-a-timeless-mission-to-drive-positive-social-change-through-advancing-medical-research-and-science
#40
JOURNAL ARTICLE
Kumsal Bayazit
No abstract text is available yet for this article.
October 7, 2023: Lancet
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