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https://www.readbyqxmd.com/read/27909716/aberrant-timeless-expression-is-associated-with-poor-clinical-survival-and-lymph-node-metastasis-in-early-stage-cervical-carcinoma
#1
Weijing Zhang, Weiling He, Yongjie Shi, Jing Zhao, Sailan Liu, Fengxiang Zhang, Jiarui Yang, Chuanmiao Xie, Yanna Zhang
TIMELESS is a highly conserved protein required for the maintenance of normal mammalian circadian oscillations and for controlling cellular metabolism and proliferation. Recently, TIMELESS was implicated in the tumorigenesis of certain cancers. However, little is known on TIMELESS protein expression and its potential as a prognostic factor in cervical cancer. Here, we investigate TIMELESS expression pattern and its clinicopathological significance in early-stage cervical carcinoma. TIMELESS mRNA and protein expression was evaluated by real-time PCR and western blot analysis in cervical cancer cell lines, a normal cervical cell line, as well as in six pairs of surgically removed cervical cancer and adjacent normal cervical tissues...
November 29, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27879518/three-month-evaluation-of-strut-healing-using-a-novel-optical-coherence-tomography-analytical-method-following-bioresorbable-polymer-everolimus-eluting-stent-implantation-in-humans-the-timeless-study
#2
Boris Vesga, Hector Hernandez, Miguel Moncada, Pawel Gasior, Sergio A H Leal, Antonio Dager, Camilo Arana, Juan A Delgado, Philippe Généreux, Akiko Maehara, Juan F Granada
AIMS: Bioresorbable polymer drug-eluting stent technologies have been considered to have the potential to enhance vascular healing by reducing polymer exposure to the vessel wall, potentially allowing the earlier discontinuation of dual antiplatelet therapy. At present, the early vascular healing response to this type of technologies is still unclear. PATIENTS AND METHODS: The TIMELESS study is a multicenter, prospective, single-arm study that enrolled real-world patients undergoing percutaneous coronary intervention...
November 22, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27822404/evolution-of-technology-in-teaching-blackboard-and-beyond-in-medical-education
#3
REVIEW
Jayakumary Muttappallymyalil, Susirith Mendis, Lisha Jenny John, Nisha Shanthakumari, Jayadevan Sreedharan, Rizwana B Shaikh
TEACHING AND LEARNING: the passing of knowledge from one generation to another - has been in existence from the earliest times of human civilization. It began in 1801, with a large piece of slate hung on the wall in a school in Scotland to provide information to a large audience at one time. In the US by mid-19th century, every class room had a blackboard to teach students. The modern version of the blackboard is either green or brown board. This was introduced in late 1960s. The whiteboards came into use during the late 1980s...
October 2016: Nepal journal of epidemiology
https://www.readbyqxmd.com/read/27821737/quasimodo-mediates-daily-and-acute-light-effects-on-drosophila-clock-neuron-excitability
#4
Edgar Buhl, Adam Bradlaugh, Maite Ogueta, Ko-Fan Chen, Ralf Stanewsky, James J L Hodge
We have characterized a light-input pathway regulating Drosophila clock neuron excitability. The molecular clock drives rhythmic electrical excitability of clock neurons, and we show that the recently discovered light-input factor Quasimodo (Qsm) regulates this variation, presumably via an Na(+), K(+), Cl(-) cotransporter (NKCC) and the Shaw K(+) channel (dKV3.1). Because of light-dependent degradation of the clock protein Timeless (Tim), constant illumination (LL) leads to a breakdown of molecular and behavioral rhythms...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27791498/exploring-the-interconnected-trauma-of-personal-social-and-structural-stressors-making-sense-of-senseless-violence
#5
Mona M Abo-Zena
Although violence is a timeless characteristic of human behavior and history, its prevalence and many forms are proliferated repeatedly through the media. In particular, "senseless" violence against both random and targeted victims puzzles and petrifies onlookers and survivors. Integrating developmental psychology with critical theory, this manuscript begins with a conceptual definition of senseless violence that is coupled with a mapping of the personal, social, and structural etiologies of such violence...
October 28, 2016: Journal of Psychology
https://www.readbyqxmd.com/read/27784754/an-rnai-screen-to-identify-protein-phosphatases-that-function-within-the-drosophila-circadian-clock
#6
Parul Agrawal, Paul E Hardin
Circadian clocks in eukaryotes keep time via cell-autonomous transcriptional feedback loops. A well-characterized example of such a transcriptional feedback loop is in Drosophila, where CLOCK-CYCLE (CLK-CYC) complexes activate transcription of period (per) and timeless (tim) genes, rising levels of PER-TIM complexes feedback to repress CLK-CYC activity, and degradation of PER and TIM permits the next cycle of CLK-CYC transcription. The timing of CLK-CYC activation and PER-TIM repression is regulated post-translationally, in part through rhythmic phosphorylation of CLK, PER and TIM...
October 26, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27764578/timeless-insights-into-prevention-of-acetaldehyde-genotoxicity
#7
P J Brooks, Kornel Schuebel
No abstract text is available yet for this article.
October 20, 2016: Cell Cycle
https://www.readbyqxmd.com/read/27761341/identification-and-temporal-expression-of-putative-circadian-clock-transcripts-in-the-amphipod-crustacean-talitrus-saltator
#8
Joseph F O'Grady, Laura S Hoelters, Martin T Swain, David C Wilcockson
BACKGROUND: Talitrus saltator is an amphipod crustacean that inhabits the supralittoral zone on sandy beaches in the Northeast Atlantic and Mediterranean. T. saltator exhibits endogenous locomotor activity rhythms and time-compensated sun and moon orientation, both of which necessitate at least one chronometric mechanism. Whilst their behaviour is well studied, currently there are no descriptions of the underlying molecular components of a biological clock in this animal, and very few in other crustacean species...
2016: PeerJ
https://www.readbyqxmd.com/read/27753822/pl-01-3-should-hypertension-treatment-targets-differ-according-to-region-and-ethnicity
#9
Lawrence Appel
With the exception of a few isolated populations, elevated blood pressure is a worldwide pandemic with staggering consequences for individuals, care givers, health care delivery systems, and insurers, including governments. It is well-recognized that the burden of hypertension and its adverse consequences is greater in low- and middle-income countries than economically developed countries. BP-related outcomes also differ by region, with a predominance of stroke in southeast Asian countries and a predominance of ischemic heart disease in the US and Western Europe...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27746889/endless-resistance-endless-antibiotics
#10
Jed F Fisher, Shahriar Mobashery
The practice of medicine was profoundly transformed by the introduction of the antibiotics (compounds isolated from Nature) and the antibacterials (compounds prepared by synthesis) for the control of bacterial infection. As a result of the extraordinary success of these compounds over decades of time, a timeless biological activity for these compounds has been presumed. This presumption is no longer. The inexorable acquisition of resistance mechanisms by bacteria is retransforming medical practice. Credible answers to this dilemma are far better recognized than they are being implemented...
January 1, 2016: MedChemComm
https://www.readbyqxmd.com/read/27704542/contextual-organismality-beyond-pattern-to-process-in-the-emergence-of-organisms
#11
Samuel L Díaz-Muñoz, Amy M Boddy, Gautam Dantas, Christopher M Waters, Judith L Bronstein
Biologists have taken the concept of organism largely for granted. However, advances in the study of chimerism, symbiosis, bacterial-eukaryote associations, and microbial behavior have prompted a redefinition of organisms as biological entities exhibiting low conflict and high cooperation among their parts. This expanded view identifies organisms in evolutionary time. However, the ecological processes, mechanisms, and traits that drive the formation of organisms remain poorly understood. Recognizing that organismality can be context dependent, we advocate elucidating the ecological contexts under which entities do or do not act as organisms...
December 2016: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/27689881/the-insulin-like-proteins-dilps-2-5-determine-diapause-inducibility-in-drosophila
#12
Luca Schiesari, Gabriele Andreatta, Charalambos P Kyriacou, Michael B O'Connor, Rodolfo Costa
Diapause is an actively induced dormancy that has evolved in Metazoa to resist environmental stresses. In temperate regions, many diapausing insects overwinter at low temperatures by blocking embryonic, larval or adult development. Despite its Afro-tropical origin, Drosophila melanogaster migrated to temperate regions of Asia and Europe where females overwinter as adults by arresting gonadal development (reproductive diapause) at temperatures <13°C. Recent work in D. melanogaster has implicated the developmental hormones dILPs-2 and/or dILP3, and dILP5, homologues of vertebrate insulin/insulin-like growth factors (IGFs), in reproductive arrest...
2016: PloS One
https://www.readbyqxmd.com/read/27642875/pl-01-3-should-hypertension-treatment-targets-differ-according-to-region-and-ethnicity
#13
Lawrence Appel
With the exception of a few isolated populations, elevated blood pressure is a worldwide pandemic with staggering consequences for individuals, care givers, health care delivery systems, and insurers, including governments. It is well-recognized that the burden of hypertension and its adverse consequences is greater in low- and middle-income countries than economically developed countries. BP-related outcomes also differ by region, with a predominance of stroke in southeast Asian countries and a predominance of ischemic heart disease in the US and Western Europe...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27598401/an-intronic-polymorphism-in-couch-potato-is-not-distributed-clinally-in-european-drosophila-melanogaster-populations-nor-does-it-affect-diapause-inducibility
#14
Valeria Zonato, Giorgio Fedele, Charalambos P Kyriacou
couch potato (cpo) encodes an RNA binding protein that has been reported to be expressed in the peripheral and central nervous system of embryos, larvae and adults, including the major endocrine organ, the ring gland. A polymorphism in the D. melanogaster cpo gene coding region displays a latitudinal cline in frequency in North American populations, but as cpo lies within the inversion In(3R)Payne, which is at high frequencies and itself shows a strong cline on this continent, interpretation of the cpo cline is not straightforward...
2016: PloS One
https://www.readbyqxmd.com/read/27587400/timeless-suppresses-the-accumulation-of-aberrant-cdc45%C3%A2-mcm2-7%C3%A2-gins-replicative-helicase-complexes-on-human-chromatin
#15
Xiaohua Xu, Jiin-Tarng Wang, Min Li, Yilun Liu
The replication licensing factor CDC6 recruits the MCM2-7 replicative helicase to the replication origin, where MCM2-7 is activated to initiate DNA replication. MCM2-7 is activated by both the CDC7-Dbf4 kinase and cyclin-dependent kinase and via interactions with CDC45 and go-ichi-ni-san complex (GINS) to form the CDC45·MCM2-7·GINS (CMG) helicase complex. TIMELESS (TIM) is important for the subsequent coupling of CMG activity to DNA polymerases for efficient DNA synthesis. However, the mechanism by which TIM regulates CMG activity for proper replication fork progression remains unclear...
October 21, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27577611/crtc-potentiates-light-independent-timeless-transcription-to-sustain-circadian-rhythms-in-drosophila
#16
Minkyung Kim, Hoyeon Lee, Jin-Hoe Hur, Joonho Choe, Chunghun Lim
Light is one of the strongest environmental time cues for entraining endogenous circadian rhythms. Emerging evidence indicates that CREB-regulated transcription co-activator 1 (CRTC1) is a key player in this pathway, stimulating light-induced Period1 (Per1) transcription in mammalian clocks. Here, we demonstrate a light-independent role of Drosophila CRTC in sustaining circadian behaviors. Genomic deletion of the crtc locus causes long but poor locomotor rhythms in constant darkness. Overexpression or RNA interference-mediated depletion of CRTC in circadian pacemaker neurons similarly impairs the free-running behavioral rhythms, implying that Drosophila clocks are sensitive to the dosage of CRTC...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27551082/changes-in-active-site-histidine-hydrogen-bonding-trigger-cryptochrome-activation
#17
Abir Ganguly, Craig C Manahan, Deniz Top, Estella F Yee, Changfan Lin, Michael W Young, Walter Thiel, Brian R Crane
Cryptochrome (CRY) is the principal light sensor of the insect circadian clock. Photoreduction of the Drosophila CRY (dCRY) flavin cofactor to the anionic semiquinone (ASQ) restructures a C-terminal tail helix (CTT) that otherwise inhibits interactions with targets that include the clock protein Timeless (TIM). All-atom molecular dynamics (MD) simulations indicate that flavin reduction destabilizes the CTT, which undergoes large-scale conformational changes (the CTT release) on short (25 ns) timescales. The CTT release correlates with the conformation and protonation state of conserved His378, which resides between the CTT and the flavin cofactor...
September 6, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27546572/the-circadian-clock-is-a-key-driver-of-steroid-hormone-production-in-drosophila
#18
Francesca Di Cara, Kirst King-Jones
Biological clocks allow organisms to anticipate daily environmental changes such as temperature fluctuations, abundance of daylight, and nutrient availability. Many circadian-controlled physiological states are coordinated by the release of systemically acting hormones, including steroids and insulin [1-7]. Thus, hormones relay circadian outputs to target tissues, and disrupting these endocrine rhythms impairs human health by affecting sleep patterns, energy homeostasis, and immune functions [8-10]. It is largely unclear, however, whether circadian circuits control hormone levels indirectly via central timekeeping neurons or whether peripheral endocrine clocks can modulate hormone synthesis directly...
September 26, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27443672/genome-wide-associations-with-flowering-time-in-switchgrass-using-exome-capture-sequencing-data
#19
Paul P Grabowski, Joseph Evans, Chris Daum, Shweta Deshpande, Kerrie W Barry, Megan Kennedy, Guillaume Ramstein, Shawn M Kaeppler, C Robin Buell, Yiwei Jiang, Michael D Casler
Flowering time is a major determinant of biomass yield in switchgrass (Panicum virgatum), a perennial bioenergy crop, because later flowering allows for an extended period of vegetative growth and increased biomass production. A better understanding of the genetic regulation of flowering time in switchgrass will aid the development of switchgrass varieties with increased biomass yields, particularly at northern latitudes, where late-flowering but southern-adapted varieties have high winter mortality. We use genotypes derived from recently published exome-capture sequencing, which mitigates challenges related to the large, highly repetitive and polyploid switchgrass genome, to perform genome-wide association studies (GWAS) using flowering time data from a switchgrass association panel in an effort to characterize the genetic architecture and genes underlying flowering time regulation in switchgrass...
July 22, 2016: New Phytologist
https://www.readbyqxmd.com/read/27395746/timeless-standards-for-species-delimitation
#20
Dalton S Amorim, Charles Morphy D Santos, Frank-Thorsten Krell, Alain Dubois, Silvio S Nihei, Otto M P Oliveira, Adrian Pont, Hojun Song, Vanessa K Verdade, Diego A Fachin, Bruna Klassa, Carlos José E Lamas, Sarah S Oliveira, Claudio J B De Carvalho, Cátia A Mello-Patiu, Eduardo Hajdu, Márcia S Couri, Vera C Silva, Renato S Capellari, Rafaela L Falaschi, Rodrigo M Feitosa, Lorenzo Prendini, José P Jr Pombal, Fernando Fernández, Rosana M Rocha, John E Lattke, Ulisses Caramaschi, Marcelo Duarte, Antonio Carlos Marques, Roberto E Reis, Olavi Kurina, Daniela M Takiya, Marcos Tavares, Daniel Silva Fernandes, Francisco Luís Franco, Fabiana Cuezzo, Dennis Paulson, Benoit Guénard, Birgit C Schlick-Steiner, Wolfgang Arthofer, Florian M Steiner, Brian L Fisher, Robert A Johnson, Thibaut Dominique Delsinne, David A Donoso, Pablo Ricardo Mulieri, Luciano Damián Patitucci, James M Carpenter, Lee Herman, David Grimaldi
Recently a new species of bombyliid fly, Marleyimyia xylocopae, was described by Marshall & Evenhuis (2015) based on two photographs taken during fieldwork in the Republic of South Africa. This species has no preserved holotype. The paper generated some buzz, especially among dipterists, because in most cases photographs taken in the field provide insufficient information for properly diagnosing and documenting species of Diptera.
2016: Zootaxa
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