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https://www.readbyqxmd.com/read/28479454/the-current-status-of-carotid-endarterectomy-part-i-randomized-trials-versus-medical-management
#1
Norman R Hertzer
A vascular surgeon is consulted to evaluate a patient because of carotid stenosis. By the time the surgeon enters the examining room or arrives at the bedside, he (she) is aware of the sex and age of the patient as well as the severity of the stenosis on a recent high-quality imaging study. After asking if the patient has had any related symptoms and how long ago they occurred, the surgeon has all of the information that is necessary to determine, in the absence of serious comorbidities, whether this patient is an appropriate candidate for carotid intervention and even how quickly it should be performed...
May 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28464854/timeless-contributes-to-the-progression-of-breast-cancer-through-activation-of-myc
#2
Limin Chi, Yujiao Zou, Ling Qin, Weifeng Ma, Yanyan Hao, Yao Tang, Rongcheng Luo, Ziqing Wu
BACKGROUND: Breast cancer is the most common malignancy and the leading cause of cancer death among women. TIMELESS (TIM), a circadian rhythm regulator, has been recently implicated in the progression of human cancer. However, the role of TIM in the progression of breast cancer has not been well-characterized. METHODS: Immunohistochemistry (IHC) staining was used to examine TIM levels in breast cancer specimens. Mammosphere formation analysis and side population analysis were used to examine the effect of TIM on the self-renewal of breast cancer stem cells...
May 2, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28426839/medical-history-in-the-hellenic-journal-of-nuclear-medicine
#3
EDITORIAL
Andreas Otte
The Hellenic Journal of Nuclear Medicine is about to celebrate its 20th anniversary end of 2017. On board of the editorial team since 2003, this journal has influenced me like a good friend over the many past years. From time to time, the journal has published interesting and valuable historical notes. They show that nuclear medicine has a history and that medicine is its basis. They also teach us today, and some of the ancient perspectives and approaches are still valid. The reader of HJNM may be interested in these historical contributions, as they are timeless...
January 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28405468/cryptochrome-genes-form-an-oscillatory-loop-independent-of-the-per-tim-loop-in-the-circadian-clockwork-of-the-cricket-gryllus-bimaculatus
#4
Atsushi Tokuoka, Taichi Q Itoh, Shinryo Hori, Outa Uryu, Yoshiki Danbara, Motoki Nose, Tetsuya Bando, Teiichi Tanimura, Kenji Tomioka
BACKGROUND: Animals exhibit circadian rhythms with a period of approximately 24 h in various physiological functions, including locomotor activity. This rhythm is controlled by an endogenous oscillatory mechanism, or circadian clock, which consists of cyclically expressed clock genes and their product proteins. cryptochrome (cry) genes are thought to be involved in the clock mechanism, and their functions have been examined extensively in holometabolous insects, but in hemimetabolous insects their role is less well understood...
2017: Zoological Letters
https://www.readbyqxmd.com/read/28360128/circadian-rhythms-and-sleep-in-drosophila-melanogaster
#5
REVIEW
Christine Dubowy, Amita Sehgal
The advantages of the model organism Drosophila melanogaster, including low genetic redundancy, functional simplicity, and the ability to conduct large-scale genetic screens, have been essential for understanding the molecular nature of circadian (∼24 hr) rhythms, and continue to be valuable in discovering novel regulators of circadian rhythms and sleep. In this review, we discuss the current understanding of these interrelated biological processes in Drosophila and the wider implications of this research...
April 2017: Genetics
https://www.readbyqxmd.com/read/28336666/how-you-makes-meaning
#6
Ariana Orvell, Ethan Kross, Susan A Gelman
"You" is one of the most common words in the English language. Although it typically refers to the person addressed ("How are you?"), "you" is also used to make timeless statements about people in general ("You win some, you lose some."). Here, we demonstrate that this ubiquitous but understudied linguistic device, known as "generic-you," has important implications for how people derive meaning from experience. Across six experiments, we found that generic-you is used to express norms in both ordinary and emotional contexts and that producing generic-you when reflecting on negative experiences allows people to "normalize" their experience by extending it beyond the self...
March 24, 2017: Science
https://www.readbyqxmd.com/read/28334766/crystal-structure-of-the-n-terminal-domain-of-human-timeless-and-its-interaction-with-tipin
#7
Sandro Holzer, Gianluca Degliesposti, Mairi L Kilkenny, Sarah L Maslen, Dijana Matak-Vinkovíc, Mark Skehel, Luca Pellegrini
Human Timeless is involved in replication fork stabilization, S-phase checkpoint activation and establishment of sister chromatid cohesion. In the cell, Timeless forms a constitutive heterodimeric complex with Tipin. Here we present the 1.85 Å crystal structure of a large N-terminal segment of human Timeless, spanning amino acids 1-463, and we show that this region of human Timeless harbours a partial binding site for Tipin. Furthermore, we identify minimal regions of the two proteins that are required for the formation of a stable Timeless-Tipin complex and provide evidence that the Timeless-Tipin interaction is based on a composite binding interface comprising different domains of Timeless...
May 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28296937/effects-of-circadian-clock-genes-and-health-related-behavior-on-metabolic-syndrome-in-a-taiwanese-population-evidence-from-association-and-interaction-analysis
#8
Eugene Lin, Po-Hsiu Kuo, Yu-Li Liu, Albert C Yang, Chung-Feng Kao, Shih-Jen Tsai
Increased risk of developing metabolic syndrome (MetS) has been associated with the circadian clock genes. In this study, we assessed whether 29 circadian clock-related genes (including ADCYAP1, ARNTL, ARNTL2, BHLHE40, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, GSK3B, HCRTR2, KLF10, NFIL3, NPAS2, NR1D1, NR1D2, PER1, PER2, PER3, REV1, RORA, RORB, RORC, SENP3, SERPINE1, TIMELESS, TIPIN, VIP, and VIPR2) are associated with MetS and its individual components independently and/or through complex interactions in a Taiwanese population...
2017: PloS One
https://www.readbyqxmd.com/read/28277898/planarian-finds-time-less-to-fight-infection
#9
Óscar Gutiérrez-Gutiérrez, Daniel A Felix, Cristina González-Estévez
No abstract text is available yet for this article.
March 2, 2017: Virulence
https://www.readbyqxmd.com/read/28235563/characterisation-analysis-of-expression-and-localisation-of-circadian-clock-genes-from-the-perspective-of-photoperiodism-in-the-aphid-acyrthosiphon-pisum
#10
Miquel Barberà, Jorge Mariano Collantes-Alegre, David Martínez-Torres
Aphids are typical photoperiodic insects that switch from viviparous parthenogenetic reproduction typical of long day seasons to oviparous sexual reproduction triggered by the shortening of photoperiod in autumn yielding an overwintering egg in which an embryonic diapause takes place. While the involvement of the circadian clock genes in photoperiodism in mammals is well established, there is still some controversy on their participation in insects. The availability of the genome of the pea aphid Acyrthosiphon pisum places this species as an excellent model to investigate the involvement of the circadian system in the aphid seasonal response...
February 22, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28216110/the-current-global-state-of-key-lifestyle-characteristics-health-and-economic-implications
#11
REVIEW
Ross Arena, Amy McNeil, Michael Sagner, Andrew P Hills
The chronic disease crisis we currently face must be addressed in rapid fashion. Cardiovascular (CV) and pulmonary diseases, diabetes as well as several forms of cancer are leading causes of morbidity and mortality globally. Collectively, these conditions have a significant impact on the quality of life of individuals, families and communities, placing an unsustainable burden on health systems. There is hope for the chronic disease crisis in that these conditions are largely preventable or can be delayed to much later in life through a timeless medicine, healthy living...
February 16, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28206928/remembering-dr-henry-w-gray-1827-1861-and-his-timeless-contribution-to-modern-medical-education
#12
Niti Shahi, Abigail L Brooks, Charles J Yeo, Scott W Cowan, Gerald A Isenberg
No abstract text is available yet for this article.
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28194770/clinical-pharmacology-therapeutics-past-present-and-future
#13
EDITORIAL
S A Waldman, A Terzic
Clinical Pharmacology & Therapeutics (CPT), the definitive and timely source for advances in human therapeutics, transcends the drug discovery, development, regulation, and utilization continuum to catalyze, evolve, and disseminate discipline-transformative knowledge. Prioritized themes and multidisciplinary content drive the science and practice of clinical pharmacology, offering a trusted point of reference. An authoritative herald across global communities, CPT is a timeless information vehicle at the vanguard of discovery, translation, and application ushering therapeutic innovation into modern healthcare...
March 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28192242/molecular-cloning-characterization-and-temporal-expression-of-the-clock-genes-period-and-timeless-in-the-oriental-river-prawn-macrobrachium-nipponense-during-female-reproductive-development
#14
SuHua Chen, Hui Qiao, HongTuo Fu, Shengming Sun, WenYi Zhang, ShuBo Jin, Yongsheng Gong, Sufei Jiang, Weiyi Xiong, YanWu
The circadian clock is crucial for sustaining rhythmic biochemical, physiological, and behavioral processes in living creatures. In this study, we isolated and characterized two circadian clock genes in Macrobrachium nipponense, period (Mnper) and timeless (Mntim). The complete Mnper cDNA measures 4283bp in length with an open reading frame encoding 1292 amino acids, including functional domains such as PER-ARNT-SIM (PAS), cytoplasmic localization domain (CLD), TIM interaction site (TIS), and nuclear localization signal (NLS)...
February 10, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28131702/geographical-analysis-of-diapause-inducibility-in-european-drosophila-melanogaster-populations
#15
Mirko Pegoraro, Valeria Zonato, Elizabeth R Tyler, Giorgio Fedele, Charalambos P Kyriacou, Eran Tauber
Seasonal overwintering in insects represents an adaptation to stressful environments and in European Drosophila melanogaster females, low temperatures and short photoperiods can induce an ovarian diapause. Diapause may represent a recent (<15Ky) adaptation to the colonisation of temperate Europe by D. melanogaster from tropical sub-Saharan Africa, because African D. melanogaster and the sibling species D. simulans, have been reported to fail to undergo diapause. Over the past few centuries, D. melanogaster have also invaded North America and Australia, and eastern populations on both continents show a predictable latitudinal cline in diapause induction...
January 25, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28126607/healthy-living-the-universal-and-timeless-medicine-for-healthspan
#16
EDITORIAL
Ross Arena, Amy McNeil, Michael Sagner, Carl J Lavie
No abstract text is available yet for this article.
March 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28109907/circadian-gene-variants-and-breast-cancer
#17
Edyta Reszka, Monika Przybek, Olav Muurlink, Beata Pepłonska
The endogenous and self-sustained circadian rhythm generated and maintained in suprachiasmatic nucleus and peripheral tissues can coordinate various molecular, biochemical and physiological processes in living organisms resulting in the adaptation to environmental cues, e.g. light. Multifactorial breast cancer etiology also involves circadian gene alterations, especially among individuals exposed to light at night. Indeed, shift work that causes circadian disruption has been classified by the International Agency for Research on Cancer as a probable human carcinogen, group 2A...
April 1, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28101904/functional-analysis-of-the-circadian-clock-gene-timeless-in-tribolium-castaneum
#18
Chengjun Li, Xiaopei Yun, Xiaojuan Yu, Bin Li
Circadian rhythms are endogenous oscillations with a period of about 24 h driven by a circadian clock. So far, the variable oscillators were designed in insects. To explore the circadian clock of Tribolium castaneum, we have cloned the clock gene timeless (Tctimeless). Its open reading frame is 3240 bp in length and consists of 10 exons. Tctimeless is highly expressed in the late pupal stage. Tissue-specific expression analysis in late adult stages revealed high expression of Tctimeless in the head, epidermis, fat body and accessory glands...
January 19, 2017: Insect Science
https://www.readbyqxmd.com/read/28095742/lithium-response-in-bipolar-disorders-and-core-clock-genes-expression
#19
Pierre A Geoffroy, Emmanuel Curis, Cindie Courtin, Jeverson Moreira, Thomas Morvillers, Bruno Etain, Jean-Louis Laplanche, Frank Bellivier, Cynthia Marie-Claire
OBJECTIVES: We examine if the lithium response is associated with changes in core clock genes expressions. METHODS: The effect of a therapeutic concentration of lithium (1mM) on the expression levels of 17 circadian genes, was examined in lymphoblastoid cell lines (LCLs) derived from two well-characterized groups of BD patients, defined as lithium non-responders (NR, n = 20) or excellent responders (ER, n = 16). Quantitative real-time PCR (qRT-PCR) were conducted at 2, 4 and 8 days (d2, d4, d8) with and without lithium exposure...
January 18, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28072861/identification-of-the-molecular-clockwork-of-the-oyster-crassostrea-gigas
#20
Mickael Perrigault, Damien Tran
Molecular clock system constitutes the origin of biological rhythms that allow organisms to anticipate cyclic environmental changes and adapt their behavior and physiology. Components of the molecular clock are largely conserved across a broad range of species but appreciable diversity in clock structure and function is also present especially in invertebrates. The present work aimed at identify and characterize molecular clockwork components in relationship with the monitoring of valve activity behavior in the oyster Crassostrea gigas...
2017: PloS One
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