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https://www.readbyqxmd.com/read/29655930/circadian-signaling-in-homarus-americanus-region-specific-de-novo-assembled-transcriptomes-show-that-both-the-brain-and-eyestalk-ganglia-possess-the-molecular-components-of-a-putative-clock-system
#1
Andrew E Christie, Andy Yu, Micah G Pascual, Vittoria Roncalli, Matthew C Cieslak, Amanda N Warner, Tess J Lameyer, Meredith E Stanhope, Patsy S Dickinson, J Joe Hull
Essentially all organisms exhibit recurring patterns of physiology/behavior that oscillate with a period of ~24-h and are synchronized to the solar day. Crustaceans are no exception, with robust circadian rhythms having been documented in many members of this arthropod subphylum. However, little is known about the molecular underpinnings of their circadian rhythmicity. Moreover, the location of the crustacean central clock has not been firmly established, although both the brain and eyestalk ganglia have been hypothesized as loci...
April 11, 2018: Marine Genomics
https://www.readbyqxmd.com/read/29611807/ck1-doubletime-activity-delays-transcription-activation-in-the-circadian-clock
#2
Deniz Top, Jenna L O'Neil, Gregory E Merz, Kritika Dusad, Brian R Crane, Michael W Young
In the Drosophila circadian clock, Period (PER) and Timeless (TIM) proteins inhibit Clock-mediated transcription of per and tim genes until PER is degraded by Doubletime/CK1 (DBT)-mediated phosphorylation, establishing a negative feedback loop. Multiple regulatory delays within this feedback loop ensure ~24 hr periodicity. Of these delays, the mechanisms that regulate delayed PER degradation (and Clock reactivation) remain unclear. Here we show that phosphorylation of certain DBT target sites within a central region of PER affect PER inhibition of Clock and the stability of the PER/TIM complex...
April 3, 2018: ELife
https://www.readbyqxmd.com/read/29604225/bedside-reasoning-on-causes-and-mechanisms-of-diseases-in-the-era-of-precision-medicine-a-timeless-story
#3
REVIEW
Dan Lipsker
This is a short reflection about bedside reasoning in clinical medicine, emphasizing the importance of distinguishing between causes and mechanisms of diseases. All complex/sporadic diseases result from interactions between a genetic predisposition and environmental factors. The main disease mechanisms resulting in clinical signs involve inflammation, insult of vessels or nerves, pharmacological or hormonal dysfunction, altered metabolism and overload, tumoral proliferations, intrinsic dysfunction, malformation and traumatism...
March 31, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29581265/circadian-clock-activity-of-cryptochrome-relies-on-tryptophan-mediated-photoreduction
#4
Changfan Lin, Deniz Top, Craig C Manahan, Michael W Young, Brian R Crane
Cryptochromes (CRYs) entrain the circadian clocks of plants and animals to light. Irradiation of the Drosophila cryptochrome (dCRY) causes reduction of an oxidized flavin cofactor by a chain of conserved tryptophan (Trp) residues. However, it is unclear how redox chemistry within the Trp chain couples to dCRY-mediated signaling. Here, we show that substitutions of four key Trp residues to redox-active tyrosine and redox-inactive phenylalanine tune the light sensitivity of dCRY photoreduction, conformational activation, cellular stability, and targeted degradation of the clock protein timeless (TIM)...
March 26, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29573099/nursing-history-as-philosophy-towards-a-critical-history-of-nursing
#5
Thomas Foth, Jette Lange, Kylie Smith
Mainstream nursing history often positions itself in opposition to philosophy and many nursing historians are reticent of theorizing. In the quest to illuminate the lives of nurses and women current historical approaches are driven by reformist aspirations but are based on the conception that nursing or caring is basically good and the timelessness of universal values. This has the effect of essentialising political categories of identity such as class, race and gender. This kind of history is about affirmation rather than friction and about the conservation of memory and musealization...
March 24, 2018: Nursing Philosophy: An International Journal for Healthcare Professionals
https://www.readbyqxmd.com/read/29555554/timeless-is-a-novel-estrogen-receptor-co-activator-involved-in-multiple-signalling-pathways-in-mcf-7-cells
#6
Chantal Beatrice Magne Nde, Gloria Casas Gimeno, Maria Docanto, Kevin C Knower, Morag J Young, Jakob Buehn, Edris Sayed, Colin D Clyne
Activation of oestrogen receptor α (ERα) stimulates cell division and tumour growth by modulating the expression of ERα target genes. This activation involves the recruitment of specific proteins with activities that are still not fully understood. Timeless, the human homologue of the Drosophila gene involved in circadian rhythm, was previously shown to be a strong predictor of tamoxifen relapse, and is involved in genomic stability and cell cycle control. In this study, we investigated the interplay between Timeless and ERα, and showed that human Timeless is an ERα coactivator...
March 16, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29541184/a-role-for-the-clock-period-circadian-regulator-2-gene-in-regulating-the-clock-gene-network-in-human-oral-squamous-cell-carcinoma-cells
#7
Yiran Ao, Qin Zhao, Kai Yang, Gang Zheng, Xiaoqing Lv, Xiaoli Su
Clock genes are the core of the circadian rhythms in the human body and are important in regulating normal physiological functions. To date, research has indicated that the clock gene, period circadian clock 2 ( PER2 ), is downregulated in numerous types of cancer, and that it is associated with cancer occurrence and progression via the regulation of various downstream cell cycle genes. However, it remains unclear whether the decreased expression of PER2 influences the expression of other clock genes in cancer cells...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29472309/photosensitive-alternative-splicing-of-the-circadian-clock-gene-timeless-is-population-specific-in-a-cold-adapted-fly-drosophila-montana
#8
Riikka Tapanainen, Darren J Parker, Maaria Kankare
To function properly, organisms must adjust their physiology, behavior and metabolism in response to a suite of varying environmental conditions. One of the central regulators of these changes is organisms' internal circadian clock, and recent evidence has suggested that the clock genes are also important in the regulation of seasonal adjustments. In particular, thermosensitive splicing of the core clock gene timeless in a cosmopolitan fly, Drosophila melanogaster , has implicated this gene to be involved in thermal adaptation...
February 22, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29459820/high-throughput-measurement-of-locomotor-sensitization-to-volatilized-cocaine-in-drosophila-melanogaster
#9
Ana Filošević, Sabina Al-Samarai, Rozi Andretić Waldowski
Drosophila melanogaster can be used to identify genes with novel functional roles in neuronal plasticity induced by repeated consumption of addictive drugs. Behavioral sensitization is a relatively simple behavioral output of plastic changes that occur in the brain after repeated exposures to drugs of abuse. The development of screening procedures for genes that control behavioral sensitization has stalled due to a lack of high-throughput behavioral tests that can be used in genetically tractable organism, such as Drosophila ...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29381321/nife-layered-double-hydroxide-nanosheet-arrays-supported-on-carbon-cloth-for-highly-sensitive-detection-of-nitrite
#10
Yue Ma, Yongchuang Wang, Donghua Xie, Yue Gu, Haimin Zhang, Guozhong Wang, Yunxia Zhang, Huijun Zhao, Po Keung Wong
Excessive uptake of nitrite has been proven to be detrimental to the ecological system and human health. Hence, there is a rising requirement for constructing effective electrochemical sensors to precisely monitor the level of nitrite. In this work, NiFe-layered double hydroxide nanosheet arrays (NiFe-LDH NSAs) have been successfully fabricated on a carbon cloth (CC) substrate via a facile one-pot hydrothermal route. By integrating the collective merits of macroporous CC and NiFe-LDH NSAs such as superior electrical conductivity, striking synergistic effect between the dual active components, enlarged electrochemically active surface area, unique three-dimensional hierarchical porous network characteristics, and fast charge transport and ion diffusion, the proposed NiFe-LDH NSAs/CC architecture can be served as a self-supporting sensor toward nitrite detection...
February 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29353056/interspecific-studies-of-circadian-genes-period-and-timeless-in-drosophila
#11
Shumaila Noreen, Mirko Pegoraro, Faisal Nouroz, Eran Tauber, Charalambos P Kyriacou
The level of rescue of clock function in genetically arrhythmic Drosophila melanogaster hosts using interspecific clock gene transformation was used to study the putative intermolecular coevolution between interacting clock proteins. Among them PER and TIM are the two important negative regulators of the circadian clock feedback loop. We transformed either the D. pseudoobscura per or tim transgenes into the corresponding arrhythmic D. melanogaster mutant (per01 or tim01) and observed >50% rhythmicity but the period of activity rhythm was either longer (D...
March 30, 2018: Gene
https://www.readbyqxmd.com/read/29318713/hybrid-feature-extraction-techniques-for-microscopic-hepatic-fibrosis-classification
#12
Dalia S Ashour, Dina M Abou Rayia, Mohamed Maher Ata, Amira S Ashour, Mustafa M Abd Elnaby
Chronic liver diseases' hallmark is the fibrosis that results in liver function failure in advanced stages. One of the serious parasitic diseases affecting the liver tissues is schistosomiasis. Immunologic reactions to Schistosoma eggs leads to accumulation of collagen in the hepatic parenchyma causing fibrosis. Thus, monitoring and reporting the staging of the histopathological information related to liver fibrosis are essential for accurate diagnosis and therapy of the chronic liver diseases. Automated assessment of the microscopic liver tissue images is an essential process...
March 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29287788/timeless2-plays-an-important-role-in-reproduction-and-circadian-rhythms-in-the-cricket-gryllus-bimaculatus
#13
Motoki Nose, Atsushi Tokuoka, Tetsuya Bando, Kenji Tomioka
The timeless2 (tim2) gene is an insect orthologue of the mammalian clock gene Timeless (mTim). Although its functional role has been extensively studied in mammals, little is known regarding its role in insects. In the present study, we obtained tim2 cDNA (Gb'tim2) from the cricket Gryllus bimaculatus and characterized its functional role in embryonic development, egg production, and circadian rhythms. Gb'tim2 gave rise to a 1432 amino acid protein, and showed approximately 65% homology to that of Drosophila melanogaster...
February 2018: Journal of Insect Physiology
https://www.readbyqxmd.com/read/29286600/looking-back-timeless-communication-and-leadership-tips
#14
Steve Adubato
No abstract text is available yet for this article.
2017: MD Advisor: a Journal for New Jersey Medical Community
https://www.readbyqxmd.com/read/29277154/comparing-behavior-and-clock-gene-expression-between-caterpillars-butterflies-and-moths
#15
Natalie Niepoth, Gao Ke, Jacobus C de Roode, Astrid T Groot
Circadian behavior is widely observed in insects; however, the mechanisms that drive its evolution remain a black box. While circadian activity rhythms are well characterized in adults within the order Lepidoptera (i.e., most butterfly species are day active, while most moths are night active), much less is known about daily activity and clock gene expression in the larval stage. Additionally, direct comparison of clock gene expression between day-active and night-active species reared together has not been quantified...
February 2018: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29235408/balint-work-and-the-creation-of-medical-knowledge
#16
John Muench
Michael Balint's pioneering work in primary care was not simply the application of psychodynamic theory to the complex problems and relationships encountered by clinicians. Rather, Balint's work was part of a wider conversation in Western epistemology that had already begun to break down the enlightenment rationalist agenda. Since the time of Descartes, we sought to find certain truth through decontextualizing and abstracting problems, and through separation of the observer from the thing observed, with a focus on finding universal timeless laws that could be generalized...
January 2018: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29233623/a-timeless-biology
#17
REVIEW
Arturo Tozzi, James F Peters, Clifford Chafin, Domenico De Falco, John S Torday
Contrary to claims that physics is timeless while biology is time-dependent, we take the opposite standpoint: physical systems' dynamics are constrained by the arrow of time, while living assemblies are time-independent. Indeed, the concepts of "constraints" and "displacements" shed new light on the role of continuous time flow in life evolution, allowing us to sketch a physical gauge theory for biological systems in long timescales. In the very short timescales of biological systems' individual lives, time looks like "frozen" and "fixed", so that the second law of thermodynamics is momentarily wrecked...
May 2018: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29187422/dependency-of-heterochromatin-domains-on-replication-factors
#18
Leonie Johanna Jahn, Bethany Mason, Peter Brøgger, Tea Toteva, Dennis Kim Nielsen, Genevieve Thon
Chromatin structure regulates both genome expression and dynamics in eukaryotes, where large heterochromatic regions are epigenetically silenced through the methylation of histone H3K9, histone deacetylation, and the assembly of repressive complexes. Previous genetic screens with the fission yeast Schizosaccharomyces pombe have led to the identification of key enzymatic activities and structural constituents of heterochromatin. We report here on additional factors discovered by screening a library of deletion mutants for silencing defects at the edge of a heterochromatic domain bound by its natural boundary-the IR-R + element-or by ectopic boundaries...
February 2, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29183263/inverse-european-latitudinal-cline-at-the-timeless-locus-of-drosophila-melanogaster-reveals-selection-on-a-clock-gene-population-genetics-of-ls-tim
#19
Valeria Zonato, Stefano Vanin, Rodolfo Costa, Eran Tauber, Charalambos P Kyriacou
The spread of adaptive genetic variants in populations is a cornerstone of evolutionary theory but with relatively few biologically well-understood examples. Previous work on the ls-tim variant of timeless, which encodes the light-sensitive circadian regulator in Drosophila melanogaster, suggests that it may have originated in southeastern Italy. Flies characterized by the new allele show photoperiod-related phenotypes likely to be adaptive in seasonal environments. ls-tim may be spreading from its point of origin in Italy by directional selection, but there are alternative explanations for its observed clinal geographical distribution, including balancing selection and demography...
February 2018: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29169033/mapping-complex-mind-states-eeg-neural-substrates-of-meditative-unified-compassionate-awareness
#20
Poppy L A Schoenberg, Andrea Ruf, John Churchill, Daniel P Brown, Judson A Brewer
Specific mental training cultivates diminished self-reference, encompassing non-duality, emptiness, awakened-awareness, and compassionate experiences. We aimed to elucidate the neural substrates of four distinct, interdependent Essence-of-Mind states: (1) timelessness, (2) non-preference, non-duality, non-conceptualization, (3) the view of luminosity and limitlessness, (4) unified compassionate experience of oneness (stable awakened-awareness). EEG data were collected from 30 advanced meditators concomitant to eyes-open/eyes-closed resting baseline, followed by 60-min of instructed practice...
January 2018: Consciousness and Cognition
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