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https://www.readbyqxmd.com/read/28206928/remembering-dr-henry-w-gray-1827-1861-and-his-timeless-contribution-to-modern-medical-education
#1
Niti Shahi, Abigail L Brooks, Charles J Yeo, Scott W Cowan, Gerald A Isenberg
No abstract text is available yet for this article.
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28194770/clinical-pharmacology-therapeutics-past-present-and-future
#2
EDITORIAL
S A Waldman, A Terzic
Clinical Pharmacology & Therapeutics (CPT), the definitive and timely source for advances in human therapeutics, transcends the drug discovery, development, regulation, and utilization continuum to catalyze, evolve, and disseminate discipline-transformative knowledge. Prioritized themes and multidisciplinary content drive the science and practice of clinical pharmacology, offering a trusted point of reference. An authoritative herald across global communities, CPT is a timeless information vehicle at the vanguard of discovery, translation, and application ushering therapeutic innovation into modern healthcare...
March 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28192242/molecular-cloning-characterization-and-temporal-expression-of-the-clock-genes-period-and-timeless-in-the-oriental-river-prawn-macrobrachium-nipponense-during-female-reproductive-development
#3
SuHua Chen, Hui Qiao, HongTuo Fu, Shengming Sun, WenYi Zhang, ShuBo Jin, Yongsheng Gong, Sufei Jiang, Weiyi Xiong, YanWu
The circadian clock is crucial for sustaining rhythmic biochemical, physiological, and behavioral processes in living creatures. In this study, we isolated and characterized two circadian clock genes in Macrobrachium nipponense, period (Mnper) and timeless (Mntim). The complete Mnper cDNA measures 4283bp in length with an open reading frame encoding 1292 amino acids, including functional domains such as PER-ARNT-SIM (PAS), cytoplasmic localization domain (CLD), TIM interaction site (TIS), and nuclear localization signal (NLS)...
February 10, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28131702/geographical-analysis-of-diapause-inducibility-in-european-drosophila-melanogaster-populations
#4
Mirko Pegoraro, Valeria Zonato, Elizabeth R Tyler, Giorgio Fedele, Charalambos P Kyriacou, Eran Tauber
Seasonal overwintering in insects represents an adaptation to stressful environments and in European Drosophila melanogaster females, low temperatures and short photoperiods can induce an ovarian diapause. Diapause may represent a recent (<15Ky) adaptation to the colonisation of temperate Europe by D. melanogaster from tropical sub-Saharan Africa, because African D. melanogaster and the sibling species D. simulans, have been reported to fail to undergo diapause. Over the past few centuries, D. melanogaster have also invaded North America and Australia, and eastern populations on both continents show a predictable latitudinal cline in diapause induction...
January 25, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28126607/healthy-living-the-universal-and-timeless-medicine-for-healthspan
#5
EDITORIAL
Ross Arena, Amy McNeil, Michael Sagner, Carl J Lavie
No abstract text is available yet for this article.
January 23, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28109907/circadian-gene-variants-and-breast-cancer
#6
Edyta Reszka, Monika Przybek, Olav Muurlink, Beata Pepłonska
The endogenous and self-sustained circadian rhythm generated and maintained in suprachiasmatic nucleus and peripheral tissues can coordinate various molecular, biochemical and physiological processes in living organisms resulting in the adaptation to environmental cues, e.g. light. Multifactorial breast cancer etiology also involves circadian gene alterations, especially among individuals exposed to light at night. Indeed, shift work that causes circadian disruption has been classified by the International Agency for Research on Cancer as a probable human carcinogen, group 2A...
April 1, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28101904/functional-analysis-of-the-circadian-clock-gene-timeless-in-tribolium-castaneum
#7
Chengjun Li, Xiaopei Yun, Xiaojuan Yu, Bin Li
Circadian rhythms are endogenous oscillations with a period of about 24 h driven by a circadian clock. So far, the variable oscillators were designed in insects. To explore the circadian clock of Tribolium castaneum, we have cloned the clock gene timeless (Tctimeless). Its open reading frame is 3240 bp in length and consists of 10 exons. Tctimeless is highly expressed in the late pupal stage. Tissue-specific expression analysis in late adult stages revealed high expression of Tctimeless in the head, epidermis, fat body and accessory glands...
January 19, 2017: Insect Science
https://www.readbyqxmd.com/read/28095742/lithium-response-in-bipolar-disorders-and-core-clock-genes-expression
#8
Pierre A Geoffroy, Emmanuel Curis, Cindie Courtin, Jeverson Moreira, Thomas Morvillers, Bruno Etain, Jean-Louis Laplanche, Frank Bellivier, Cynthia Marie-Claire
OBJECTIVES: We examine if the lithium response is associated with changes in core clock genes expressions. METHODS: The effect of a therapeutic concentration of lithium (1mM) on the expression levels of 17 circadian genes, was examined in lymphoblastoid cell lines (LCLs) derived from two well-characterized groups of BD patients, defined as lithium non-responders (NR, n = 20) or excellent responders (ER, n = 16). Quantitative real-time PCR (qRT-PCR) were conducted at 2, 4 and 8 days (d2, d4, d8) with and without lithium exposure...
January 18, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28072861/identification-of-the-molecular-clockwork-of-the-oyster-crassostrea-gigas
#9
Mickael Perrigault, Damien Tran
Molecular clock system constitutes the origin of biological rhythms that allow organisms to anticipate cyclic environmental changes and adapt their behavior and physiology. Components of the molecular clock are largely conserved across a broad range of species but appreciable diversity in clock structure and function is also present especially in invertebrates. The present work aimed at identify and characterize molecular clockwork components in relationship with the monitoring of valve activity behavior in the oyster Crassostrea gigas...
2017: PloS One
https://www.readbyqxmd.com/read/28051908/antimicrobial-capacity-of-the-freshwater-planarians-against-s-aureus-is-under-the-control-of-timeless
#10
Landry Laure Tsoumtsa, Cedric Torre, Virginie Trouplin, Benjamin Coiffard, Gregory Gimenez, Jean-Louis Mege, Eric Ghigo
Planarians, which are non-parasitic flatworms, are highly resistant to bacterial infections. To better understand the mechanisms underlying this resistance, we investigated the role of the circadian machinery in the anti-bacterial response of the freshwater planarian Schmidtea mediterranea. We identified Smed-Tim from S. mediterranea as a homolog of the mammalian clock gene Tim. We showed via RNA interference that Smed-Tim is required for the anti-microbial activities of Schmidtea mediterranea against Staphylococcus aureus infection during the light/dark cycle...
January 4, 2017: Virulence
https://www.readbyqxmd.com/read/28005725/ephemeral-or-timeless-the-bront%C3%A3-sisters
#11
Kun Hwang
No abstract text is available yet for this article.
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28000948/the-expression-patterns-of-the-clock-genes-period-and-timeless-are-affected-by-photoperiod-in-the-mediterranean-corn-stalk-borer-sesamia-nonagrioides
#12
Dimitrios Kontogiannatos, Theodoros Gkouvitsas, Anna Kourti
To obtain clues to the link between the molecular mechanism of circadian and photoperiod clocks, we cloned two circadian clock genes, period (per) and timeless (tim) from the moth Sesamia nonagrioides, which undergoes facultative diapause controlled by photoperiod. Sequence analysis revealed a high degree of conservation among the compared insects fοr both genes. We also investigated the expression patterns of per and tim in brains of larvae growing under 16L:8D (long days), constant darkness (DD) and 10L:14D (short days) conditions by qPCR assays...
January 2017: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/27956169/differential-expression-of-circadian-clock-genes-in-two-strains-of-beetles-reveals-candidates-related-to-photoperiodic-induction-of-summer-diapause
#13
Li Zhu, Wen Liu, Qian-Qian Tan, Chao-Liang Lei, Xiao-Ping Wang
Diapause (also known as dormancy) is a state of arrested development induced by photoperiod or temperature that allows insects to survive adverse environmental conditions. By regulating diapause induction, the circadian clock is involved in short-day-induced winter diapause but whether this is also the case in long-day (LD)-induced summer diapause remains unknown. The cabbage beetle Colaphellus bowringi could enter summer diapause under LD conditions. However, a non-photoperiodic-diapause (NPD) strain of this species, which was developed in our laboratory by artificial selection, could not enter diapause under LD photoperiod...
March 1, 2017: Gene
https://www.readbyqxmd.com/read/27938526/a-cusp-catastrophe-model-of-tax-behavior
#14
Ioannis Katerelos, Nikolaos Varotsis
The paper addresses the timeless failure of the tax system in Greece despite its constant reform, highlighting the study of tax evasion phenomenon with a different approach. This study aims to assess tax behavior with a model of cusp catastrophe, where fear and peer pressure are control parameters. The survey involved 320 taxpayers from the entire Greek territory. Mathematical study using linear analysis and catastrophe modelling showed that a non-linear system is dramatically better in representing tax behavior than is any linear model...
January 2017: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/27909716/aberrant-timeless-expression-is-associated-with-poor-clinical-survival-and-lymph-node-metastasis-in-early-stage-cervical-carcinoma
#15
Weijing Zhang, Weiling He, Yongjie Shi, Jing Zhao, Sailan Liu, Fengxiang Zhang, Jiarui Yang, Chuanmiao Xie, Yanna Zhang
TIMELESS is a highly conserved protein required for the maintenance of normal mammalian circadian oscillations and for controlling cellular metabolism and proliferation. Recently, TIMELESS was implicated in the tumorigenesis of certain cancers. However, little is known on TIMELESS protein expression and its potential as a prognostic factor in cervical cancer. Here, we investigate TIMELESS expression pattern and its clinicopathological significance in early-stage cervical carcinoma. TIMELESS mRNA and protein expression was evaluated by real-time PCR and western blot analysis in cervical cancer cell lines, a normal cervical cell line, as well as in six pairs of surgically removed cervical cancer and adjacent normal cervical tissues...
January 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/27879518/three-month-evaluation-of-strut-healing-using-a-novel-optical-coherence-tomography-analytical-method-following-bioresorbable-polymer-everolimus-eluting-stent-implantation-in-humans-the-timeless-study
#16
Boris Vesga, Hector Hernandez, Miguel Moncada, Pawel Gasior, Sergio Higuera, Antonio Dager, Camilo Arana, Juan A Delgado, Philippe Généreux, Akiko Maehara, Juan F Granada
AIMS: Bioresorbable polymer drug-eluting stent technologies have been considered to have the potential to enhance vascular healing by reducing polymer exposure to the vessel wall, potentially allowing the earlier discontinuation of dual antiplatelet therapy. At present, the early vascular healing response to this type of technologies is still unclear. PATIENTS AND METHODS: The TIMELESS study is a multicenter, prospective, single-arm study that enrolled real-world patients undergoing percutaneous coronary intervention...
March 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/27822404/evolution-of-technology-in-teaching-blackboard-and-beyond-in-medical-education
#17
REVIEW
Jayakumary Muttappallymyalil, Susirith Mendis, Lisha Jenny John, Nisha Shanthakumari, Jayadevan Sreedharan, Rizwana B Shaikh
TEACHING AND LEARNING: the passing of knowledge from one generation to another - has been in existence from the earliest times of human civilization. It began in 1801, with a large piece of slate hung on the wall in a school in Scotland to provide information to a large audience at one time. In the US by mid-19th century, every class room had a blackboard to teach students. The modern version of the blackboard is either green or brown board. This was introduced in late 1960s. The whiteboards came into use during the late 1980s...
October 2016: Nepal journal of epidemiology
https://www.readbyqxmd.com/read/27821737/quasimodo-mediates-daily-and-acute-light-effects-on-drosophila-clock-neuron-excitability
#18
Edgar Buhl, Adam Bradlaugh, Maite Ogueta, Ko-Fan Chen, Ralf Stanewsky, James J L Hodge
We have characterized a light-input pathway regulating Drosophila clock neuron excitability. The molecular clock drives rhythmic electrical excitability of clock neurons, and we show that the recently discovered light-input factor Quasimodo (Qsm) regulates this variation, presumably via an Na(+), K(+), Cl(-) cotransporter (NKCC) and the Shaw K(+) channel (dKV3.1). Because of light-dependent degradation of the clock protein Timeless (Tim), constant illumination (LL) leads to a breakdown of molecular and behavioral rhythms...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27791498/exploring-the-interconnected-trauma-of-personal-social-and-structural-stressors-making-sense-of-senseless-violence
#19
Mona M Abo-Zena
Although violence is a timeless characteristic of human behavior and history, its prevalence and many forms are proliferated repeatedly through the media. In particular, "senseless" violence against both random and targeted victims puzzles and petrifies onlookers and survivors. Integrating developmental psychology with critical theory, this manuscript begins with a conceptual definition of senseless violence that is coupled with a mapping of the personal, social, and structural etiologies of such violence...
January 2, 2017: Journal of Psychology
https://www.readbyqxmd.com/read/27784754/an-rnai-screen-to-identify-protein-phosphatases-that-function-within-the-drosophila-circadian-clock
#20
Parul Agrawal, Paul E Hardin
Circadian clocks in eukaryotes keep time via cell-autonomous transcriptional feedback loops. A well-characterized example of such a transcriptional feedback loop is in Drosophila, where CLOCK-CYCLE (CLK-CYC) complexes activate transcription of period (per) and timeless (tim) genes, rising levels of PER-TIM complexes feed-back to repress CLK-CYC activity, and degradation of PER and TIM permits the next cycle of CLK-CYC transcription. The timing of CLK-CYC activation and PER-TIM repression is regulated posttranslationally, in part through rhythmic phosphorylation of CLK, PER, and TIM...
December 7, 2016: G3: Genes—Genomes—Genetics
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