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https://www.readbyqxmd.com/read/28914422/normative-data-for-ivc-diameter-and-its-correlation-with-the-somatic-parameters-in-healthy-indian-children
#1
Kushagra Taneja, Virendra Kumar, Rama Anand, Harish K Pemde
OBJECTIVE: To determine the normative data for inferior vena cava (IVC) diameter in children and its correlation with various somatic parameters like height, weight and body surface area in Indian children. Readily available baseline data of IVC diameter in normal children shall be of great help in rapid assessment of variations in sick children. METHODS: Total 475 healthy children aged one month to 12 y visiting out patient clinics (OPD's) were enrolled in this study...
September 15, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28912592/accurate-immune-repertoire-sequencing-reveals-malaria-infection-driven-antibody-lineage-diversification-in-young-children
#2
Ben S Wendel, Chenfeng He, Mingjuan Qu, Di Wu, Stefany M Hernandez, Ke-Yue Ma, Eugene W Liu, Jun Xiao, Peter D Crompton, Susan K Pierce, Pengyu Ren, Keke Chen, Ning Jiang
Accurately measuring antibody repertoire sequence composition in a small amount of blood is challenging yet important for understanding repertoire responses to infection and vaccination. We develop molecular identifier clustering-based immune repertoire sequencing (MIDCIRS) and use it to study age-related antibody repertoire development and diversification before and during acute malaria in infants (< 12 months old) and toddlers (12-47 months old) with 4-8 ml of blood. Here, we show this accurate and high-coverage repertoire-sequencing method can use as few as 1000 naive B cells...
September 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/28898342/-an-update-on-inpatient-treatment-of-anorexia-nervosa-practical-recommendations
#3
Nicole Vásquez, Pascuala Urrejola, Melina Vogel
Anorexia Nervosa (AN) is the psychiatric illness with the highest mortality, especially if it is associated with psychiatric and somatic comorbidity. Medical complications can be multiple and jeopardize the normal development of children and adolescents, even permanently. Although its prevalence is lower compared with other psychiatric disorders, its tendency to chronicity and the severity of its consequences are remarkable. Although outpatient treatment of anorexia is privileged as far as possible, the risks associated with poor response to treatment or lack of adherence of the patient or family, require the possibility of hospitalization at any time of the disease...
May 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28890102/-anorexia-in-prepubescent-adolescents
#4
REVIEW
Catherine Doyen
Anorexia in young prepubescent patients is often linked to clinical signs occurring in early childhood. While therapies offer somatic, dietetic or medication-based treatments, the psychotherapeutic approach gives children and their families the opportunity to talk.
September 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28889788/exploring-perspectives-on-restraint-during-medical-procedures-in-paediatric-care-a-qualitative-interview-study-with-nurses-and-physicians
#5
Edel Jannecke Svendsen, Reidar Pedersen, Anne Moen, Ida Torunn Bjørk
The aim of this study was to explore nurses' and physicians' perspectives on and reasoning about the use of restraint during medical procedures on newly admitted preschoolers in somatic hospital care. We analysed qualitative data from individual interviews with a video recall session at the end with seven physicians and eight nurses. They had earlier participated in video recorded peripheral vein cannulations on preschool children. The data were collected between May 2012 and May 2013 at a paediatric hospital unit in Norway...
December 2017: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/28888350/anterior-cingulate-cortex-grey-matter-volume-abnormalities-in-adolescents-with-ptsd-after-childhood-sexual-abuse
#6
Mirjam A Rinne-Albers, J Nienke Pannekoek, Marie-José van Hoof, Natasja D van Lang, Francien Lamers-Winkelman, Serge A Rombouts, Nic J van der Wee, Robert R Vermeiren
Adverse childhood experiences (ACE) substantially increase the risk of later psychiatric and somatic pathology. While neurobiological factors are likely to play a mediating role, specific insights are lacking. The scarce neuroimaging studies in traumatised pediatric populations have provided inconsistent results, potentially due to the inclusion of different types of trauma. To further improve our understanding of the neurobiology of pediatric psychotrauma, this study seeks to investigate abnormalities in grey matter volume (GMV) in a homogeneous group of adolescents with posttraumatic stress disorder (PTSD) due to childhood sexual abuse (CSA) and the relationship between GMV and symptom severity...
September 6, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28883794/a-meta-analysis-on-sex-differences-in-resting-state-vagal-activity-in-children-and-adolescents
#7
REVIEW
Julian Koenig, Joshua A Rash, Tavis S Campbell, Julian F Thayer, Michael Kaess
Lower vagal activity is associated with psychopathology independent of age. Research suggests that alterations of vagal activity precede the development of psychopathology. The present review aimed to quantify sex differences in vagal activity in children and adolescents. Studies reporting on sex differences on measures of vagally-mediated heart rate variability derived from short-term recordings under resting conditions in boys and girls were included. Drawing on data from more than 5,000 children and adolescents, we provide evidence that healthy young girls display lower vagal activity and greater mean heart rate compared to boys, a finding that may have implications for risk associated with the development of internalizing psychopathology and somatic ill-health...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28883268/acute-myeloid-leukemia-in-adolescents-and-young-adults-from-the-viewpoint-of-physicians
#8
Yachiyo Kuwatsuka
Based on various studies, the survival of adolescent and young adults (AYAs) with acute myeloid leukemia (AML) was reportedly similar to or worse than younger children. AYAs with AML treated in adult institutions are usually offered the same treatment as that of the older adults. Although pediatric protocols generally include intensified regimens compared with adult protocols, it is still controversial whether an intensified pediatric AML regimen results in an improved survival for the AYA population. Somatic mutations have proven to be significantly prognostic in AML...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28872989/orthodontic-treatment-in-conjunction-with-twin-bock-treatment-and-growth-hormone-therapy-in-silver-russell-syndrome
#9
Su-Jin Ko, Ji Young Seo, Yong-Dae Kwon, Kyounga Cheon, Jae Hyun Park
Silver-Russell syndrome (SRS) is a very rare genetic disorder characterized by intrauterine growth retardation, short stature, and typical craniofacial abnormalities including micrognathia. While growth hormone (GH) therapy in children with SRS significantly improves somatic growth, functional orthopedic treatment can also be effective in adolescents with mandibular deficiency. We report the effects of Phase 1 functional orthopedic treatment of a twin-block appliance in conjunction with GH administration in a 9-year-old boy with GH deficiency and SRS, and the result of the subsequent Phase 2 orthodontic treatment...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28855279/telomere-length-dynamics-in-early-life-the-blood-and-muscle-model
#10
Sanjeev Sabharwal, Simon Verhulst, George Guirguis, Jeremy D Kark, Carlos Labat, Natalie E Roche, Kristina Martimucci, Krunal Patel, Debra S Heller, Masayuki Kimura, Donald Chuang, Anne Chuang, Athanase Benetos, Abraham Aviv
Telomere length (TL) trajectories in somatic tissues during human growth and development are poorly understood. We examined a blood-and-muscle model during early life, focusing on TL trajectories in leukocytes, representing the highly proliferative hematopoietic system, and skeletal muscle, a minimally proliferative tissue. Leukocyte TL (LTL) and skeletal muscle TL (MTL) were measured in 28 fetuses and 73 children. LTL and MTL were highly variable across individuals (sd: fetal LTL = 0.72 kb, MTL = 0.72 kb; children LTL = 0...
August 29, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28852250/delusion-of-triplet-pregnancy-in-abdominal-cavity-a-case-report-with-a-review-of-literature
#11
Shri Gopal Goyal, Ananya Mahapatra, Priti Kumari Goyal, Sudhir Kumar Khandelwal
The two terms, pseudocyesis and delusion of pregnancy, were frequently used for pseudopregnancy. Delusion of pregnancy is a special form of hypochondriacal/somatic delusion reported in various psychiatric and organic disorders. The origin of the delusion of pregnancy in schizophrenia has often been explained by psycho-analytic interpretations attributing wish fulfilling, protective role to false beliefs, and mother establishes an undisturbed union with her fetus during pregnancy, which eliminate loneliness and helplessness...
July 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28844203/neonatal-renal-and-inferior-vena-cava-thrombosis-associated-with-fetal-thrombotic-vasculopathy-a-case-report
#12
Lorenzo Giacchetti, Martina De Gaudenzi, Andrea Leoncini, Elisabetta Ferrucci, Valdo Pezzoli, Manuela Albisetti
BACKGROUND: Fetal thrombotic vasculopathy is a described placental diagnosis associated with adverse perinatal outcomes. It may also predispose children to somatic thromboembolic events. As far as we know, this is the first case of inferior vena cava thrombosis associated with fetal thrombotic vasculopathy in a completely asymptomatic newborn. CASE PRESENTATION: We report the case of an asymptomatic, full-term Turkish male neonate delivered at 39 weeks of gestation diagnosed as having thrombosis of the renal vein and inferior vena cava...
August 28, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28842941/characterization-of-early-communicative-behavior-in-mouse-models-of-neurofibromatosis-type-1
#13
Susan E Maloney, Krystal C Chandler, Corina Anastasaki, Michael A Rieger, David H Gutmann, Joseph D Dougherty
Neurofibromatosis type 1 (NF1) is a monogenic neurodevelopmental disease caused by germline loss-of-function mutations in the NF1 tumor suppressor gene. Cognitive impairments are observed in approximately 80% of children with this disease, with 45-60% exhibiting autism spectrum disorder (ASD) symptomatology. In light of the high comorbidity rate between ASD and NF1, we assessed early communicative behavior by maternal-separation induced pup ultrasonic vocalizations (USV) and developmental milestones in two distinct Nf1 genetically engineered models, one modeling clinical germline heterozygous loss of Nf1 function (Nf1(+/-) mice), and a second with somatic biallelic Nf1 inactivation in neuroglial progenitor cells (Nf1(GFAP) CKO mice)...
August 26, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28840960/parental-hospital-treated-somatic-illnesses-and-psychosis-of-the-offspring-the-northern-finland-birth-cohort-1986-study
#14
Sami Räsänen, Mika Niemelä, Tanja Nordström, Helinä Hakko, Marianne Haapea, Catherine A Marshall, Jouko Miettunen
AIM: The aim of this study was to investigate whether parental somatic illnesses during childhood increase the risk for later psychosis in the offspring. In addition, we examined which parental illnesses in particular are associated with increased risk of psychosis in the offspring. METHOD: The data of the Northern Finland Birth Cohort 1986 (NFBC 1986), included 9137 children born alive in northern Finland between the July 1, 1985, and the June 30, 1986. Information regarding the parents' somatic morbidity was collected through various healthcare registers up to age 28 of the cohort members...
August 25, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28840747/pediatric-somatic-symptom-and-related-disorders-primary-care-provider-perspectives
#15
Nasuh Malas, Laura Donohue, Robin J Cook, Steven M Leber, Kristin A Kullgren
Somatization, or physical symptoms that are inconsistent with a physiological cause that may or may not involve an identified stressor, is common in outpatient pediatrics. When these symptoms persist, they can impair function and progress to a somatic symptom and related disorder (SSRD), resulting in increased health care use and increased demands on primary care providers (PCPs). We performed a needs assessment among PCPs to better understand how best to support providers caring for children with SSRDs. Pediatric PCPs (n = 77) were surveyed to better understand their training, experience, perceptions, and practices of SSRD care...
August 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28835820/the-coexistence-of-psychiatric-and-gastrointestinal-problems-in-children-with-restrictive-eating-in-a-nationwide-swedish-twin-study
#16
Jakob Täljemark, Maria Råstam, Paul Lichtenstein, Henrik Anckarsäter, Nóra Kerekes
BACKGROUND: Restrictive eating problems are rare in children but overrepresented in those with neurodevelopmental problems. Comorbidities decrease wellbeing in affected individuals but research in the area is relatively scarce. This study describes phenotypes, regarding psychiatric and gastrointestinal comorbidities, in children with restrictive eating problems. METHODS: A parental telephone interview was conducted in 9- or 12-year old twins (n = 19,130) in the Child and Adolescent Twin Study in Sweden...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/28834788/associations-between-family-member-bmi-and-obesity-status-of-children-with-autism-spectrum-disorder
#17
Jack Dempsey, Allison G Dempsey, Robert G Voigt, Sonia Monteiro
OBJECTIVE: To determine whether there is an association between parent and sibling obesity status and obesity status in children with autism spectrum disorder (ASD). METHODS: We examined predictors of obesity in children with ASD with body mass index data for the proband, 1 sibling, and 2 parents using data from the multisite Simons Simplex Collection. RESULTS: In a stepwise logistic regression model, proband obesity status was associated with obesity status of the sibling (odds ratio [OR] 2...
August 22, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28832654/the-bereavement-experience-of-adolescents-and-early-young-adults-with-cancer-peer-and-parental-loss-due-to-death-is-associated-with-increased-risk-of-adverse-psychological-outcomes
#18
Liza-Marie Johnson, Carlos Torres, April Sykes, Deborah V Gibson, Justin N Baker
BACKGROUND: Adolescents commonly experience loss due to death, and perceived closeness to the deceased can often increase the intensity of bereavement. Adolescents and early young adult (AeYA) oncology patients may recall previous losses or experience new losses, possibly of other children with cancer, while coping with their own increased risk of mortality. The bereavement experiences of AeYA patients are not well described in the literature. METHODS AND FINDINGS: This analysis of bereavement sought to describe the prevalence and types of losses, the support following a death, and the impact of loss on AeYAs aged 13-21 years with malignant disease (or a hematologic disorder requiring allogeneic transplant)...
2017: PloS One
https://www.readbyqxmd.com/read/28821510/social-and-somatic-determinants-of-underweight-overweight-and-obesity-at-5-years-of-age-a-norwegian-regional-cohort-study
#19
Hilde Mjell Donkor, Jacob Holter Grundt, Pétur Benedikt Júlíusson, Geir Egil Eide, Jørgen Hurum, Robert Bjerknes, Trond Markestad
OBJECTIVE: To identify associations between the weight groups underweight (UW), overweight (OW) and obesity (OB) at 5 years of age and exposures related to pregnancy, anthropometric measures at birth, sociodemographic factors, and family health, anthropometric measures and habits. DESIGN: Regional cohort study. SETTING: Oppland County, Norway. METHODS: Pregnancy data were obtained from a prospective perinatal register for children born in the county, and weight and height were measured by midwives at birth and by public health nurses at 5 years...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28820751/importance-of-pcr-based-tumor-testing-in-the-evaluation-of-lynch-syndrome-associated-endometrial-cancer
#20
Amanda S Bruegl, Annessa Kernberg, Russell R Broaddus
Lynch syndrome (LS) is a hereditary cancer syndrome caused by a germline mutation in a DNA mismatch repair gene, usually MLH1, MSH2, MSH6, or PMS2. The most common cancers associated with LS are colorectal adenocarcinoma and endometrial carcinoma. Identification of women with LS-associated endometrial cancer is important, as these women and their affected siblings and children are at-risk of developing these same cancers. Germline testing of all endometrial cancer patients is not cost effective, and screening using young age of cancer diagnosis and/or presence of family history of syndrome-associated is underutilized and ineffective...
August 17, 2017: Advances in Anatomic Pathology
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