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AQP7

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https://www.readbyqxmd.com/read/29387386/body-condition-score-prior-to-parturition-is-associated-with-plasma-and-adipose-tissue-biomarkers-of-lipid-metabolism-and-inflammation-in-holstein-cows
#1
Abdulrahman Alharthi, Zheng Zhou, Vincenzo Lopreiato, Erminio Trevisi, Juan J Loor
Background: Previous research has revealed a strong inflammatory response within adipose (AT) tissue during the transition into lactation. Whether this effect is a result of oxidative stress induced by lipolysis and fatty acid oxidation associated with differences in prepartum body condition score remains to be determined. The objectives of this study were to investigate systemic biomarkers of energy balance and inflammation and the expression of lipid metabolism- and inflammation-related genes in AT during the transition period in dairy cows...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29300344/implications-of-aquaglyceroporin-7-in-energy-metabolism
#2
REVIEW
Francesco Maria Iena, Janne Lebeck
The aquaglyceroporin AQP7 is a pore-forming transmembrane protein that facilitates the transport of glycerol across cell membranes. Glycerol is utilized both in carbohydrate and lipid metabolism. It is primarily stored in white adipose tissue as part of the triglyceride molecules. During states with increased lipolysis, such as fasting and diabetes, glycerol is released from adipose tissue and metabolized in other tissues. AQP7 is expressed in adipose tissue where it facilitates the efflux of glycerol, and AQP7 deficiency has been linked to increased glycerol kinase activity and triglyceride accumulation in adipose tissue, leading to obesity and secondary development of insulin resistance...
January 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29203835/purification-and-functional-comparison-of-nine-human-aquaporins-produced-in-saccharomyces-cerevisiae-for-the-purpose-of-biophysical-characterization
#3
Frederik Bühring Bjørkskov, Simon Lyngaa Krabbe, Casper Normann Nurup, Julie Winkel Missel, Mariana Spulber, Julie Bomholt, Karen Molbaek, Claus Helix-Nielsen, Kamil Gotfryd, Pontus Gourdon, Per Amstrup Pedersen
The sparse number of high-resolution human membrane protein structures severely restricts our comprehension of molecular physiology and ability to exploit rational drug design. In the search for a standardized, cheap and easily handled human membrane protein production platform, we thoroughly investigated the capacity of S. cerevisiae to deliver high yields of prime quality human AQPs, focusing on poorly characterized members including some previously shown to be difficult to isolate. Exploiting GFP labeled forms we comprehensively optimized production and purification procedures resulting in satisfactory yields of all nine AQP targets...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29186031/lipopolysaccharide-modifies-glycerol-permeability-and-metabolism-in-3t3-l1-adipocytes
#4
Jeanne Durendale Chiadak, Patrizia Gena, Françoise Gregoire, Nargis Bolaky, Valérie Delforge, Jason Perret, Giuseppe Calamita, Christine Delporte
Aquaglyceroporins-aquaporin membrane channels (AQP) that conduct glycerol and other small neutral solutes in addition to water-play major roles in obesity. In adipocytes, aquaglyceroporins mediate glycerol uptake and release across the plasma membrane, which are two key steps for triacylglycerols (TAGs) synthesis (lipogenesis) and hydrolysis (lipolysis). The aim of this study was to assess both glycerol permeability and metabolism in undifferentiated 3T3-L1 cells (UDCs) as well as in untreated (CTL-DCs) versus lipopolysaccharide (LPS-DCs)-treated differentiated 3T3-L1 adipocytes...
November 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29052330/aquaporins-in-the-male-reproductive-tract-and-sperm-functional-implications-and-cryobiology
#5
REVIEW
M Yeste, R Morató, J E Rodríguez-Gil, S Bonet, N Prieto-Martínez
Aquaporins (AQPs) play a vital role for the transport of water and solutes across cell membranes. Classification of these ubiquitous proteins into three categories (orthodox AQPs, aquaglyceroporins and superaquaporins) is based on their sequence similarity and substrate selectivity. In the male reproductive tract of mammals, most AQPs (except AQP6 and AQP12) are found in different organs (including testis, efferent ducts and epididymis). AQP1 and AQP9 are the most abundant AQPs in the efferent ducts and epididymis and play a crucial role for the secretion/reabsorption dynamics of luminal fluid during sperm transport and maturation...
October 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29052325/first-evidence-for-the-presence-of-aquaporins-in-stallion-sperm
#6
S Bonilla-Correal, F Noto, E Garcia-Bonavila, J E Rodríguez-Gil, M Yeste, J Miro
Aquaporins (AQPs) are transmembrane proteins found in all cells and are responsible for the transport of water and small solutes. While these proteins have been found in the spermatozoa of humans, rodents, pigs and cattle, where not only do they play a role for the regulation of sperm volume but are also related with the sperm resilience to withstand freeze-thawing procedures, their presence in stallion sperm is yet to be reported. Therefore, the objectives of this work were as follows: (i) to determine whether AQP3, AQP7 and AQP11 are present in stallion sperm and (ii) to investigate whether the relative amounts of these three AQPs play any role in the cryopreservation success...
October 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28941027/relationship-of-aquaporins-3-aqp3-7-aqp7-and-11-aqp11-with-boar-sperm-resilience-to-withstand-freeze-thawing-procedures
#7
N Prieto-Martínez, I Vilagran, R Morató, M M Rivera Del Álamo, J E Rodríguez-Gil, S Bonet, M Yeste
Cryopreservation is the most suitable method to preserve boar spermatozoa over long-term storage. However, freeze-thawing protocols inflict extensive damage to sperm cells, reducing their viability and compromising their fertilizing ability. In addition, high individual variability is known to exist between boar ejaculates, which may be classified as of good (GFE) or poor (PFE) freezability. While conventional spermiogram parameters fail to predict sperm cryotolerance in fresh spermatozoa, high levels of certain proteins, also known as freezability markers, have been found to be related to the sperm resilience to withstand freeze-thawing procedures...
September 21, 2017: Andrology
https://www.readbyqxmd.com/read/28914342/quantification-of-the-intracellular-life-time-of-water-molecules-to-measure-transport-rates-of-human-aquaglyceroporins
#8
Madelene Palmgren, Malin Hernebring, Stefanie Eriksson, Karin Elbing, Cecilia Geijer, Samo Lasič, Peter Dahl, Jesper S Hansen, Daniel Topgaard, Karin Lindkvist-Petersson
Orthodox aquaporins are transmembrane channel proteins that facilitate rapid diffusion of water, while aquaglyceroporins facilitate the diffusion of small uncharged molecules such as glycerol and arsenic trioxide. Aquaglyceroporins play important roles in human physiology, in particular for glycerol metabolism and arsenic detoxification. We have developed a unique system applying the strain of the yeast Pichia pastoris, where the endogenous aquaporins/aquaglyceroporins have been removed and human aquaglyceroporins AQP3, AQP7, and AQP9 are recombinantly expressed enabling comparative permeability measurements between the expressed proteins...
September 15, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28854272/overall-survival-in-egfr-mutated-non-small-cell-lung-cancer-patients-treated-with-afatinib-after-egfr-tki-and-resistant-mechanisms-upon-disease-progression
#9
MULTICENTER STUDY
A J van der Wekken, J L Kuiper, A Saber, M M Terpstra, J Wei, T J N Hiltermann, E Thunnissen, D A M Heideman, W Timens, E Schuuring, K Kok, E F Smit, A van den Berg, H J M Groen
PURPOSE: To determine survival in afatinib-treated patients after treatment with first-generation EGFR tyrosine kinase inhibitors (TKIs) and to study resistance mechanisms in afatinib-resistant tumors. METHODS: Characteristics and survival of patients treated with afatinib after resistance to erlotinib or gefitinib in two large Dutch centers were collected. Whole exome sequencing (WES) and pathway analysis was performed on available pre- and post-afatinib tumor biopsies and normal tissue...
2017: PloS One
https://www.readbyqxmd.com/read/28718791/relationship-between-aging-related-skin-dryness-and-aquaporins
#10
Nobutomo Ikarashi, Risako Kon, Miho Kaneko, Nanaho Mizukami, Yoshiki Kusunoki, Kiyoshi Sugiyama
Skin function deteriorates with aging, and the dermal water content decreases. In this study, we have analyzed the mechanism of aging-related skin dryness focusing on aquaporins (AQPs), which are the water channels. Mice aged 3 and 20 months were designated as young and aged mice, respectively, to be used in the experiments. No differences were observed in transepidermal water loss between the young mice and aged mice. However, the dermal water content in aged mice was significantly lower than that in young mice, thus showing skin dryness...
July 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28633944/gene-expression-analysis-identify-a-metabolic-and-cell-function-alterations-as-a-hallmark-of-obesity-without-metabolic-syndrome-in-peripheral-blood-a-pilot-study
#11
Daniel Antonio de Luis, Raquel Almansa, Rocío Aller, Olatz Izaola, E Romero
BACKGROUND: Understanding molecular basis involved in overweight is an important first step in developing therapeutic pathways against excess in body weight gain. OBJECTIVE: The purpose of our pilot study was to evaluate the gene expression profiles in the peripheral blood of obese patients without other metabolic complications. DESIGN: A sample of 17 obese patients without metabolic syndrome and 15 non obese control subjects was evaluated in a prospective way...
June 10, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28584298/role-of-aquaporin-7-in-ghrelin-and-glp-1-induced-improvement-of-pancreatic-%C3%AE-cell-function-after-sleeve-gastrectomy-in-obese-rats
#12
L Méndez-Giménez, S Becerril, S P Camões, I V da Silva, C Rodrigues, R Moncada, V Valentí, V Catalán, J Gómez-Ambrosi, J P Miranda, G Soveral, G Frühbeck, A Rodríguez
BACKGROUND/OBJECTIVES: Glycerol is a key metabolite for lipid accumulation in insulin-sensitive tissues as well as for pancreatic insulin secretion. We examined the role of aquaporin-7 (AQP7), the main glycerol channel in β-cells, and AQP12, an aquaporin related to pancreatic damage, in the improvement of pancreatic function and steatosis after sleeve gastrectomy in diet-induced obese rats. SUBJECTS/METHODS: Male Wistar obese rats (n=125) were subjected to surgical (sham operation and sleeve gastrectomy) or dietary (pair-fed to the amount of food eaten by sleeve-gastrectomized animals) interventions...
September 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28570579/global-transcriptome-profiling-identifies-klf15-and-slc25a10-as-modifiers-of-adipocytes-insulin-sensitivity-in-obese-women
#13
Agné Kulyté, Anna Ehrlund, Peter Arner, Ingrid Dahlman
Although the mechanisms linking obesity to insulin resistance (IR) and type 2 diabetes (T2D) are not entirely understood, it is likely that alterations of adipose tissue function are involved. The aim of this study was to identify new genes controlling insulin sensitivity in adipocytes from obese women with either insulin resistant (OIR) or sensitive (OIS) adipocytes. Insulin sensitivity was first determined by measuring lipogenesis in isolated adipocytes from abdominal subcutaneous white adipose tissue (WAT) in a large observational study...
2017: PloS One
https://www.readbyqxmd.com/read/28501567/depletion-of-jmjd1c-impairs-adipogenesis-in-murine-3t3-l1-cells
#14
Florian Buerger, Silvana Müller, Nadja Ney, Juliane Weiner, John T Heiker, Sonja Kallendrusch, Peter Kovacs, Dorit Schleinitz, Joachim Thiery, Sonja C Stadler, Ralph Burkhardt
Differentiation of adipocytes is a highly regulated process modulated by multiple transcriptional co-activators and co-repressors. JMJD1C belongs to the family of jumonji C (jmjC) domain-containing histone demethylases and was originally described as a ligand-dependent co-activator of thyroid hormone and androgen receptors. Here, we explored the potential role of Jmjd1c in white adipocyte differentiation. To investigate the relevance of Jmjd1c in adipogenesis, murine 3T3-L1 preadipocyte cells with transient knock-down of Jmjd1c (3T3_Jmjd1c) were generated...
May 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28489425/tissue-specific-effects-of-estrogen-on-glycerol-channel-aquaporin-7-expression-in-an-ovariectomized-mouse-model-of-menopause
#15
B Jin, X Chen, L Xing, W Xu, X Fu, J Zhu, X Mou, Z Wang, J Shu
OBJECTIVE: Elevated fat mass and redistribution of body fat are commonly observed in postmenopausal women. Aquaporin 7 (AQP7), a unique glycerol permeable integral membrane protein, has been associated with the onset of obesity. We hypothesized that estrogen supplementation could counteract this fat accumulation and redistribution through tissue-specific modulation of AQP7. METHODS: We measured fat depot weight, adipocyte size, and the expression of AQP7 and glycerol kinase (GK) in visceral and subcutaneous fat tissues of ovariectomized mice supplemented with or without 17β-estradiol...
May 10, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28258577/aquaporins-in-obesity
#16
REVIEW
Inês Vieira da Silva, Graça Soveral
Obesity is one of the most important metabolic disorders of this century and is associated with a cluster of the most dangerous cardiovascular disease risk factors, such as insulin resistance and diabetes , dyslipidemia and hypertension , collectively named Metabolic Syndrome. The role of aquaporins in glycerol metabolism facilitating glycerol release from the adipose tissue and distribution to various tissues and organs, unveils these membrane channels as important players in lipid balance and energy homeostasis and points to their involvement in a variety of pathophysiological mechanisms including insulin resistance, obesity and diabetes...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28258571/aquaporins-in-urinary-system
#17
REVIEW
Yingjie Li, Weiling Wang, Tao Jiang, Baoxue Yang
Several aquaporin (AQP )-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2 -6 in the collecting duct; AQP7 in the proximal tubule; AQP8 in the proximal tubule and collecting duct; and AQP11 in the endoplasmic reticulum of proximal tubule cells. AQP2 is the vasopressin-regulated water channel that is important in hereditary and acquired diseases affecting urine-concentrating ability. The roles of AQPs in renal physiology and transepithelial water transport have been determined using AQP knockout mouse models...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28258568/aquaporins-in-cardiovascular-system
#18
REVIEW
Lu Tie, Di Wang, Yundi Shi, Xuejun Li
Recent studies have shown that some aquaporins (AQPs ), including AQP1, AQP4, AQP7 and AQP9, are expressed in endothelial cells, vascular smooth muscle cells and heart of cardiovascular system. These AQPs are involved in the cardiovascular function and in pathological process of related diseases, such as cerebral ischemia , congestion heart failure , hypertension and angiogenesis. Therefore, it is important to understand the accurate association between AQPs and cardiovascular system, which may provide novel approaches to prevent and treat related diseases...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28258567/aquaporins-in-nervous-system
#19
REVIEW
Mengmeng Xu, Ming Xiao, Shao Li, Baoxue Yang
Aquaporins (AQPs ) mediate water flux between the four distinct water compartments in the central nervous system (CNS). In the present chapter, we mainly focus on the expression and function of the 9 AQPs expressed in the CNS, which include five members of aquaporin subfamily: AQP1, AQP4, AQP5, AQP6, and AQP8; three members of aquaglyceroporin subfamily: AQP3, AQP7, and AQP9; and one member of superaquaporin subfamily: AQP11. In addition, AQP1, AQP2 and AQP4 expressed in the peripheral nervous system (PNS) are also reviewed...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28166973/short-term-hypertonic-exposure-enhances-in%C3%A2-vitro-follicle-growth-and-meiotic-competence-of-enclosed-oocytes-while-modestly-affecting-mrna-expression-of-aquaporin-and-steroidogenic-genes-in-the-domestic-cat-model
#20
N Songsasen, C Thongkittidilok, K Yamamizu, D E Wildt, P Comizzoli
Using the domestic cat as a non-rodent, larger animal model, the objective was to determine the impact of a brief incubation in a hypertonic microenvironment on (1) ovarian follicle and oocyte growth in vitro, (2) developmental capacity of the resident oocyte, and (3) expression of aquaporin (AQP) genes in parallel with genes involved in regulation of folliculogenesis. In Study 1: Secondary or early antral follicles encapsulated in 0.5% alginate were allocated to one of three treatment groups: 1) culture in standard medium at 290 mOsm for 15 d (Control); 2) incubation in 350 mOsm medium for 1 h followed by culture in standard medium for 15 d (Hypertonic-1h); or 3) incubation in 350 mOsm medium for 24 h followed by incubation in standard medium for additional 14 d (Hypertonic-24h)...
March 1, 2017: Theriogenology
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