L Méndez-Giménez, S Becerril, S P Camões, I V da Silva, C Rodrigues, R Moncada, V Valentí, V Catalán, J Gómez-Ambrosi, J P Miranda, G Soveral, G Frühbeck, A Rodríguez
BACKGROUND/OBJECTIVES: Glycerol is a key metabolite for lipid accumulation in insulin-sensitive tissues as well as for pancreatic insulin secretion. We examined the role of aquaporin-7 (AQP7), the main glycerol channel in β-cells, and AQP12, an aquaporin related to pancreatic damage, in the improvement of pancreatic function and steatosis after sleeve gastrectomy in diet-induced obese rats. SUBJECTS/METHODS: Male Wistar obese rats (n=125) were subjected to surgical (sham operation and sleeve gastrectomy) or dietary (pair-fed to the amount of food eaten by sleeve-gastrectomized animals) interventions...
September 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity