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Adult congenital heart

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https://www.readbyqxmd.com/read/29922523/infective-endocarditis-associated-with-atrial-septal-defect-in-an-intravenous-drug-abuser-a-case-report
#1
Maha Jahangir, Marrium Nawaz, Fareha Jabbar, Fahad Khan, Nimra Hasnain
Atrial septal defect (ASD) is a common congenital abnormality, which accounts for 20-40% of all the adult patients with congenital heart diseases. Due to the slow velocity of shunt flow, ASD has a negligible risk for infective endocarditis (IE). However, intravenous drug abuse (IVDA) is a potential cause for IE. IE remains a diagnostic and therapeutic challenge. Our case report demonstrates the atypical presentation of IE in an ASD patient. The diagnosis was made on the basis of modified Duke criteria, and blood cultures were found out to be positive for methicillin-resistant Staphylococcus aureus (MRSA)...
April 15, 2018: Curēus
https://www.readbyqxmd.com/read/29922434/gestational-diabetes-influences-the-expression-of-hypertrophic-genes-in-left-ventricle-of-rat-s-offspring
#2
Elia Saragard Kermani, Zahra Nazari, Mehdi Mehdizadeh, Majid Shahbazi, Mohammad Jafar Golalipour
Objectives: Gestational diabetes increases the risk of congenital heart disease in the offspring, but the molecular mechanism underlying this process remains unclear. Therefore, the current study was conducted to assess the effects of induced gestational diabetes on expression of some involved genes in cardiac hypertrophy in the offspring of diabetic rats. Materials and Methods: Diabetes was induced in 40 adult Wistar rats by intraperitoneal injection of 45 mg/kg of streptozotocin...
May 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29915955/population-pharmacokinetic-modeling-of-remifentanil-in-infants-with-unrepaired-tetralogy-of-fallot
#3
Jing Chang, Yang Shen, Yue Huang, Ying Sun, Mei-Hua Cai, Jing Niu, Li-Ming Zhang, Ji-Jian Zheng, Ma-Zhong Zhang
BACKGROUND: Although there is literature suggesting that pathophysiologic changes in children with congenital heart disease alter the pharmacokinetics of anesthetics and may result in dosage adjustment, limited information exists regarding the pharmacokinetics of remifentanil in infants with unrepaired tetralogy of Fallot (TOF). The objectives of the current analysis were to characterize the population pharmacokinetics of remifentanil in infants, and to evaluate the effects of TOF on remifentanil's pharmacokinetics...
June 19, 2018: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29911014/biventricular-noncompaction-cardiomyopathy-accompanied-by-severe-pulmonary-valvular-stenosis-and-patent-foramen-ovale
#4
Kurtulus Karauzum, Irem Yilmaz Karauzum, Tayfun Sahin, Teoman Kilic
Myocardial non-compaction (NC) is a rare genetic cardiomyopathy commonly believed to develop an intrauterine arrest of endomyocardial morphogenesis. NC is characterized by markedly hypertrabeculations in left ventricle or both ventricles with deep intertrabecular recesses. NC is usually seen isolated, but sometimes other congenital heart abnormalities may accompany to the myocardial NC. In this article we have presented an adult patient with biventricular myocardial NC cardiomyopathy accompanied by severe valvular pulmonary stenosis and patent foramen ovale...
April 2018: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29902465/national-benchmarks-of-proportions-of-patients-receiving-transfusions-during-pediatric-heart-surgery
#5
Vyas M Kartha, Mohamed Rehman, Jeffrey P Jacobs, Marshall L Jacobs, David Vener, Kevin D Hill, James M Meza, Sean M O'Brien, Liqi Feng, Karen Chiswell, Neil A Goldenberg, Sara K Pasquali, Pirooz Eghtesady, Vinay Badhwar
BACKGROUND: To determine national benchmarks and assess variability across centers, the STS Congenital Heart Surgery Database (CHSD) was analyzed to document proportions of patients receiving intraoperative blood transfusion during open heart surgery. METHODS: Index CPB operations reported in the STS CHSD (2014-2015) were potentially eligible for inclusion. Data from centers with > 15% missing data for packed red blood cell (PRBC) transfusion were excluded, as were individual records missing information about PRBC transfusion...
June 11, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29899714/the-role-of-clinical-psychology-and-peer-to-peer-support-in-the-management-of-chronic-medical-conditions-a-practical-example-with-adults-with-congenital-heart-disease
#6
Edward Callus, Gabriella Pravettoni
Clinical psychology services and peer to peer support can both contribute in increasing the psychological wellbeing of patients with chronic medical conditions. In this perspective paper, indications are given about the provision these services for the specific case of adults with congenital heart disease. These patients are at an increased risk of psychological distress, neurocognitive deficits, and social challenges. The psychosocial characteristics and mental health treatment preferences of these patients are briefly described, followed by guidelines and indications for the implementation of clinical psychology services...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29891239/prevalence-and-prognostic-significance-of-pulmonary-artery-aneurysms-in-adults-with-congenital-heart-disease
#7
Pastora Gallego, María José Rodríguez-Puras, Pilar Serrano Gotarredona, Israel Valverde, Begoña Manso, Antonio González-Calle, Alejandro Adsuar, Jose M Cubero, Luis Díaz de la Llera, Antonio Ordoñez, Amir-Reza Hosseinpour
BACKGROUND: Prevalence and prognostic significance of pulmonary artery (PA) dilatation in congenital heart disease (CHD) have never been studied systematically. METHODS: Chest X-rays of 1192 consecutive adults with CHD were reviewed. Major diameter of the PA was determined by imaging techniques in those with PA dilatation. A value >29 mm was considered abnormal. Data on anatomy, hemodynamics, residual lesions and outcomes were retrospectively collected. RESULTS: Overall prevalence of PA dilatation was 18%...
June 2, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29886573/severe-right-ventricular-hypertrophy-in-a-patient-with-extracardiac-and-intracardiac-shunt
#8
Mohit Pahuja, Aiden Abidov
Cardiac MRI is a complementary and confirmatory modality to a clinical echocardiography in diagnosing patients with complex adult congenital heart disease, especially in presence of great vessel abnormalities. We present a unique case of a patient with pulmonary hypertension (PH), severe right ventricular hypertrophy, Gerbode defect, and a large patent ductus arteriosus (PDA). The diagnosis of PDA was not visualized on prior serial echocardiograms and discovered on a comprehensive cardiac MRI/Chest MR angiogram...
June 10, 2018: Echocardiography
https://www.readbyqxmd.com/read/29885688/pulmonary-hypertension-registry-of-kerala-india-pro-kerala-clinical-characteristics-and-practice-patterns
#9
S Harikrishnan, G Sanjay, M Ashishkumar, Jaideep Menon, Gopalan Nair Rajesh, Raman Krishna Kumar, A George Koshy, Thankachan V Attacheril, Raju George, Eapen Punnoose, S M Ashraf, S R Arun, Mohammed Cholakkal, Panniyammakal Jeemon
BACKGROUND: Epidemiological data on pulmonary hypertension (PH) are scarce from developing countries including India. METHODS: We established a multi-center registry of PH, the PRO-KERALA registry, in Kerala, India. Fifty hospitals enrolled consecutive adult (>18 years) patients for one year. Echocardiographic criteria (right ventricular systolic pressure - RVSP > 50 mmHg) or invasively obtained mean pulmonary artery pressure > 25 mmHg was the criteria for entry...
August 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29883655/pediatric-coronary-artery-bypass-surgery-for-congenital-heart-disease
#10
REVIEW
Soichiro Kitamura
BACKGROUND: Pediatric coronary artery bypass surgery (PCABS) for congenital heart disease has become increasingly important in infants and children undergoing modern cardiac surgery, because of its life-saving potential in unsuccessful coronary transfer surgery. This review summarizes the current surgical role of PCABS for treating congenital heart diseases. METHODS: Databases, mainly PUBMED, were searched for relevant publications regarding coronary bypass surgery in the pediatric population, from 1970 (commencement) to March 2018...
June 5, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29882316/-they-re-kept-in-a-bubble-healthcare-professionals-views-on-transitioning-young-adults-with-congenital-heart-disease-from-paediatric-to-adult-care
#11
A McLoughlin, C Matthews, T M Hickey
BACKGROUND: Due to medical advances, growing numbers of adolescents with congenital heart disease (CHD) survive into adulthood and transferring from paediatric to adult healthcare. This transfer is significant step in a young person's life, and this study examines the views of Irish healthcare professionals' on how best to manage this transition. METHODS: Purposeful sampling was used to invite participation by healthcare professionals (HCPs) from a variety of disciplines whose caseloads include adolescents and young adults with CHD...
June 7, 2018: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29882186/cardiopulmonary-exercise-testing-for-surgical-risk-stratification-in-adults-with-congenital-heart-disease
#12
Trevor Birkey, Jennifer Dixon, Roni Jacobsen, Salil Ginde, Melodee Nugent, Ke Yan, Pippa Simpson, Joshua Kovach
Adult congenital heart disease (ACHD) patients often require repeat cardiothoracic surgery, which may result in significant morbidity and mortality. Currently, there are few pre-operative risk assessment tools available. In the general adult population, pre-operative cardiopulmonary exercise testing (CPET) has a predictive value for post-operative morbidity and mortality following major non-cardiac surgery. The utility of CPET for risk assessment in ACHD patients requiring cardiothoracic surgery has not been evaluated...
June 7, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29877302/combined-surgical-and-medical-therapy-for-candida-prosthetic-endocarditis-in-a-patient-with-repaired-tetralogy-of-fallot
#13
Kana Kubota, Katsura Soma, Masae Uehara, Toshiro Inaba, Akihito Saito, Norihiko Takeda, Masaru Hatano, Hiroyuki Morita, Ryo Inuzuka, Yasutaka Hirata, Atsushi Yao, Issei Komuro
Candida prosthetic endocarditis (CPE) is an uncommon and fatal complication in adults with congenital heart disease. The current guidelines for the management of fungal endocarditis recommend a combination of surgical and medical therapy. However, it still remains uncertain when surgical management in CPE patients should be performed. Therefore, the prognosis of CPE patients is very poor. Here we report a case of CPE in a 31-year-old woman who had undergone surgical repair for tetralogy of Fallot during childhood and pulmonary valve replacement at the age of 21 years...
June 6, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29875858/a-very-rare-case-of-cor-triatriatum-with-severe-mitral-regurgitation
#14
Selman Dumani, Ermal Likaj, Edlira Ruci, Ervin Bejko, Ali Refatllari
BACKGROUND: Cor triatriatum sinister is rare congenital heart disease. It is mainly presented in childhood and often accompanied with other congenital anomalies. The cases with cor triatriatum treated surgically in adults and accompanied with severe mitral regurgitation are very rare. CASE REPORT: We present a case with diagnosed cor triatriatum and severe mitral regurgitation. The diagnose was made by echocardiography. She was a female 25 years that was hospitalised with signs of heart failure NYHA II-III...
May 20, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29872120/rapamycin-attenuates-pathological-hypertrophy-caused-by-an-absence-of-trabecular-formation
#15
Nicole D Fleming, Leigh A Samsa, David Hassel, Li Qian, Jiandong Liu
Cardiac trabeculae are mesh-like muscular structures within ventricular walls. Subtle perturbations in trabeculation are associated with many congenital heart diseases (CHDs), and complete failure to form trabeculae leads to embryonic lethality. Despite the severe consequence of an absence of trabecular formation, the exact function of trabeculae remains unclear. Since ErbB2 signaling plays a direct and essential role in trabecular initiation, in this study, we utilized the erbb2 zebrafish mutant as a model to address the function of trabeculae in the heart...
June 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29859889/myocardial-specific-r-spondin3-drives-proliferation-of-the-coronary-stems-primarily-through-the-leucine-rich-repeat-g-protein-coupled-receptor-lgr4
#16
Fabio Da Silva, Filippo Massa, Fariba Jian Motamedi, Valerie Vidal, Ana Sofia Rocha, Elodie P Gregoire, Chen-Leng Cai, Kay Dietrich Wagner, Andreas Schedl
Coronary artery anomalies are common congenital disorders with serious consequences in adult life. Coronary circulation begins when the coronary stems form connections between the aorta and the developing vascular plexus. We recently identified the WNT signaling modulator R-spondin 3 (Rspo3), as a crucial regulator of coronary stem proliferation. Using expression analysis and tissue-specific deletion we now demonstrate that Rspo3 is primarily produced by cardiomyocytes. Moreover, we have employed CRISPR/Cas9 technology to generate novel Lgr4-null alleles that showed a significant decrease in coronary stem proliferation and thus phenocopied the coronary artery defects seen in Rspo3 mutants...
May 31, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29859704/risk-of-thromboembolic-complications-in-adult-congenital-heart-disease-a-literature-review
#17
REVIEW
Clement Karsenty, Alexandre Zhao, Eloi Marijon, Magalie Ladouceur
Adult congenital heart disease (ACHD) is a constantly expanding population with challenging issues. Initial medical and surgical treatments are seldom curative, and the majority of patients still experience late sequelae and complications, especially thromboembolic events. These common and potentially life-threating adverse events are probably dramatically underdiagnosed. Better identification and understanding of thromboembolic risk factors are essential to prevent long-term related morbidities. In addition to specific situations associated with a high risk of thromboembolic events (Fontan circulation, cyanotic congenital heart disease), atrial arrhythmia has been recognized as an important risk factor for thromboembolic events in ACHD...
May 30, 2018: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29843839/posterior-cerebellar-volume-and-executive-function-in-young-adults-with-congenital-heart-disease
#18
Eric S Semmel, Vonetta M Dotson, Thomas G Burns, William T Mahle, Tricia Z King
OBJECTIVES: As the number of adolescents and young adults (AYAs) surviving congenital heart disease (CHD) grows, studies of long-term outcomes are needed. CHD research documents poor executive function (EF) and cerebellum (CB) abnormalities in children. We examined whether AYAs with CHD exhibit reduced EF and CB volumes. We hypothesized a double dissociation such that the posterior CB is related to EF while the anterior CB is related to motor function. We also investigated whether the CB contributes to EF above and beyond processing speed...
May 30, 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29808125/cor-triatriatum-sinister-an-unusual-cause-of-atrial-fibrillation-in-adults
#19
Christopher Hayes, Shuangbo Liu, James W Tam, Malek Kass
Cor triatriatum is a rare congenital heart defect that is associated with an increased risk for developing atrial fibrillation. We report a case of a healthy 38-year-old man who presented in decompensated heart failure and atrial fibrillation with a rapid ventricular response. A transthoracic echocardiogram (TTE) demonstrated severe biventricular dysfunction and dilatation in addition to cor triatriatum sinister. He was diuresed with resolution of his symptoms and spontaneously converted back to sinus rhythm...
2018: Case Reports in Cardiology
https://www.readbyqxmd.com/read/29803061/cerebral-abscess-in-a-young-adult-with-hypoplastic-left-heart-syndrome
#20
Garret P Greeneway, James L West, Daniel E Couture, Wesley Hsu
BACKGROUND: Cerebral abscesses are rare, potentially life-threatening entities that result from local spread or hematogenous dissemination to the brain. Prompt diagnosis and initiation of treatment is key in lowering morbidity and preventing mortality associated with cerebral abscesses. Congenital heart diseases with right-to-left intracardiac shunts can be complicated by brain abscesses via paradoxical embolism of infected microthrombi. Hypoplastic left heart syndrome (HLHS) is a rare congenital heart disease characterized by an underdeveloped left heart that utilizes intracardiac shunting to achieve adequate systemic circulation...
May 23, 2018: World Neurosurgery
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