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https://www.readbyqxmd.com/read/29660159/cannabis-and-anti-cancer-drugs-societal-usage-and-expected-pharmacological-interactions-a-review
#1
REVIEW
Régis Bouquié, Guillaume Deslandes, Hélène Mazaré, Marion Cogné, Julien Mahé, Matthieu Grégoire, Pascale Jolliet
Cannabis is a plant that has been used for centuries to relieve a wide range of symptoms. Since the 1960s, interest in medical research into this plant has grown steadily. Already very popular for recreational use, a growing number of consumers not accustomed to using cannabis for psychoactive purposes, have begun to use it as an alternative or complement to mainstream pharmaceutical medicines. The principal unsubstantiated or "social" uses of cannabis are based mainly on data that is at best controversial, but usually not scientifically proven...
April 16, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29658971/characterization-and-expression-of-the-abc-family-g-group-in-dangshansuli-pear-pyrus-bretschneideri-rehd-and-its-russet-mutant
#2
Zhaoqi Hou, Bing Jia, Fei Li, Pu Liu, Li Liu, Zhenfeng Ye, Liwu Zhu, Qi Wang, Wei Heng
The plant genes encoding ABCGs that have been identified to date play a role in suberin formation in response to abiotic and biotic stress. In the present study, 80 ABCG genes were identified in 'Dangshansuli' Chinese white pear and designated as PbABCGs. Based on the structural characteristics and phylogenetic analysis, the PbABCG family genes could be classified into seven main groups: classes A-G. Segmental and dispersed duplications were the primary forces underlying the PbABCG gene family expansion in 'Dangshansuli' pear...
January 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29658612/let-7d-3p-is-associated-with-apoptosis-and-response-to-neoadjuvant-chemotherapy-in-ovarian-cancer
#3
Raúl García-Vázquez, Dolores Gallardo Rincón, Erika Ruiz-García, Abelardo Meneses García, Olga N Hernández De La Cruz, Horacio Astudillo-De La Vega, David Isla-Ortiz, Laurence A Marchat, Yarely M Salinas-Vera, Ángeles Carlos-Reyes, Sullivan López-González, Rosalio Ramos-Payan, César López-Camarillo
Altered expression of microRNAs contributes to the heterogeneous biological behavior of human malignancies and it may correlate with the clinical pathological features of patients. The let-7 microRNA family is frequently downregulated in human cancers and its aberrant expression may be a useful marker for prediction of the clinical response to therapy in patients. In the present study, we analyzed the expression of three members of the let-7 family (let-7a-3p, let-7d-3p and let-7f), which remains largely uncharacterized in ovarian cancer tissues...
April 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29610494/structural-basis-of-small-molecule-inhibition-of-human-multidrug-transporter-abcg2
#4
Scott M Jackson, Ioannis Manolaridis, Julia Kowal, Melanie Zechner, Nicholas M I Taylor, Manuel Bause, Stefanie Bauer, Ruben Bartholomaeus, Guenther Bernhardt, Burkhard Koenig, Armin Buschauer, Henning Stahlberg, Karl-Heinz Altmann, Kaspar P Locher
ABCG2 is an ATP-binding cassette (ABC) transporter that protects tissues against xenobiotics, affects the pharmacokinetics of drugs and contributes to multidrug resistance. Although many inhibitors and modulators of ABCG2 have been developed, understanding their structure-activity relationship requires high-resolution structural insight. Here, we present cryo-EM structures of human ABCG2 bound to synthetic derivatives of the fumitremorgin C-related inhibitor Ko143 or the multidrug resistance modulator tariquidar...
April 2, 2018: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/29602905/the-plant-defense-signal-galactinol-is-specifically-used-as-a-nutrient-by-the-bacterial-pathogen-agrobacterium-fabrum
#5
Thibault Meyer, Armelle Vigouroux, Magali Aumont-Niçaise, Gilles Comte, Ludovic Vial, Celine Lavire, Solange Morera
The bacterial plant pathogen Agrobacterium fabrum uses periplasmic binding proteins (PBPs) along with ABC transporters to import a wide variety of plant molecules as nutrients. Nonetheless, how A. fabrum acquires plant metabolites is incompletely understood. Using genetic approaches and affinity measurements, we identified here the PBP MelB and its transporter as being responsible for the uptake of the raffinose family of oligosaccharides (RFOs), which are the most widespread Dgalactose containing oligosaccharides in higher plants...
March 30, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29596045/positive-behaviour-support-training-for-staff-for-treating-challenging-behaviour-in-people-with-intellectual-disabilities-a-cluster-rct
#6
Angela Hassiotis, Michaela Poppe, Andre Strydom, Victoria Vickerstaff, Ian Hall, Jason Crabtree, Rumana Omar, Michael King, Rachael Hunter, Alessandro Bosco, Asit Biswas, Victoria Ratti, Jessica Blickwedel, Vivien Cooper, William Howie, Mike Crawford
BACKGROUND: Preliminary studies have indicated that training staff in Positive Behaviour Support (PBS) may help to reduce challenging behaviour among people with intellectual disability (ID). OBJECTIVE: To evaluate whether or not such training is clinically effective in reducing challenging behaviour in routine care. The study also included longer-term follow-up (approximately 36 months). DESIGN: A multicentre, single-blind, two-arm, parallel-cluster randomised controlled trial...
March 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29584668/atp-binding-cassette-transporter-vcam-from-vibrio-cholerae-is-dependent-on-the-outer-membrane-factor-family-for-its-function
#7
Wen-Jung Lu, Hsuan-Ju Lin, Thamarai K Janganan, Cheng-Yi Li, Wei-Chiang Chin, Vassiliy N Bavro, Hong-Ting Victor Lin
Vibrio cholerae ATP-binding cassette transporter VcaM ( V. cholerae ABC multidrug resistance pump) has previously been shown to confer resistance to a variety of medically important drugs. In this study, we set to analyse its properties both in vitro in detergent-solubilised state and in vivo to differentiate its dependency on auxiliary proteins for its function. We report the first detailed kinetic parameters of purified VcaM and the rate of phosphate (Pi) production. To determine the possible functional dependencies of VcaM on the tripartite efflux pumps we then utilized different E...
March 27, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29572210/a-novel-glaesserella-sp-isolated-from-severe-respiratory-infections-in-pigs-has-a-mosaic-genome-with-virulence-factors-putatively-acquired-by-horizontal-transfer
#8
Anne E Watt, Glenn F Browning, Alistair R Legione, Rhys N Bushell, Andrew Stent, Ross S Cutler, Neil D Young, Marc S Marenda
An unknown member of the family Pasteurellaceae was repeatedly isolated from severe pulmonary lesions in 20-24 week old pigs reared on the same farm in Victoria, Australia. The aetiological diagnosis of the disease was inconclusive. The complete genome sequence analysis of one strain, 15-184, revealed some phylogenic proximity to Glaesserella (Haemophilus) parasuis , the cause of Glasser's disease. However, sequences of the 16S rRNA and housekeeping genes, as well as average nucleotide identity scores, differed from all other known species in the family Pasteurellaceae The protein content of 15-184 was composite, with 60% of coding sequences matching known G...
March 23, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29552197/dynamic-quantitative-detection-of-abc-transporter-family-promoter-methylation-by-ms-hrm-for-predicting-mdr-in-pancreatic-cancer
#9
Lie Yao, Jichun Gu, Yishen Mao, Xinju Zhang, Xiaoyi Wang, Chen Jin, Deliang Fu, Ji Li
The main focus of the present study was to evaluate whether ABC transporter family promoter methylation predicted multidrug resistance in gemcitabine-resistant cancer cell lines (BxPC-3/Gem and PANC-1/Gem). Using low concentrations of gemcitabine, the cell lines acquired drug resistance with different initial gemcitabine concentrations. A novel technology, methylation-sensitive high-resolution melting, was used to monitor the dynamic changes of ABC transporter family promoter methylation, including ATP binding cassette subfamily B member 1 (ABCB1), ATP binding cassette subfamily C (ABCC) and ATP binding cassette subfamily G member 2 (ABCG2) mRNA expression...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29551997/sulfate-transporters-in-dissimilatory-sulfate-reducing-microorganisms-a-comparative-genomics-analysis
#10
REVIEW
Angeliki Marietou, Hans Røy, Bo B Jørgensen, Kasper U Kjeldsen
The first step in the sulfate reduction pathway is the transport of sulfate across the cell membrane. This uptake has a major effect on sulfate reduction rates. Much of the information available on sulfate transport was obtained by studies on assimilatory sulfate reduction, where sulfate transporters were identified among several types of protein families. Despite our growing knowledge on the physiology of dissimilatory sulfate-reducing microorganisms (SRM) there are no studies identifying the proteins involved in sulfate uptake in members of this ecologically important group of anaerobes...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29551395/unaffected-first-degree-relatives-of-essential-tremor-cases-have-more-imbalance-than-age-matched-control-subjects
#11
Elan D Louis, James H Meyers, Ashley D Cristal, Ruby Hickman, Pam Factor-Litvak
BACKGROUND: Endophenotypes are measurable clinical characteristics that may be present in individuals with increased risk for disease (e.g., unaffected family members). Endophenotypes are useful; they may clarify diagnosis in genetic studies and foster the development of animal models. In recent years, problems with balance and mild gait ataxia have been associated with essential tremor (ET). We compared gait and balance of first-degree relatives of ET cases (FD-ET) to that of age-matched controls (Co)...
March 13, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29547272/new-inhibitors-of-breast-cancer-resistance-protein-abcg2-containing-a-2-4-disubstituted-pyridopyrimidine-scaffold
#12
Michael K Krapf, Jennifer Gallus, Sahel Vahdati, Michael Wiese
Multidrug resistance occurring during cancer chemotherapy is a major obstacle for effectiveness and response to therapy and is often caused by ATP-binding cassette (ABC) efflux transporters. Belonging to the family of ABC transporters, breast cancer resistance protein is getting more and more in the spotlight of research. As a strategy to overcome multidrug resistance, inhibitors of ABC transporters were synthesized, which could be applied in combination with cytostatic drugs. For this purpose, 2,4-disubstituted pyridopyrimidine derivatives were synthesized...
March 16, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29534913/species-specific-serine-threonine-protein-kinase-pkb2-of-bifidobacterium-longum-subsp-longum-genetic-environment-and-substrate-specificity
#13
V Z Nezametdinova, D A Mavletova, M G Alekseeva, M S Chekalina, N V Zakharevich, V N Danilenko
The objective of this study was to determine for phosphorylated substrates of the species-specific serine-threonine protein kinase (STPK) Pkb2 from Bifidobacterium longum subsp. longum GT15. Two approaches were employed: analyses of phosphorylated membrane vesicles protein spectra following kinase reactions and analyses of the genes surrounding pkb2. A bioinformatics analysis of the genes surrounding pkb2 found a species-specific gene cluster PFNA in the genomes of 34 different bifidobacterial species. The identified cluster consisted of 5-8 genes depending on the species...
March 10, 2018: Anaerobe
https://www.readbyqxmd.com/read/29507090/iron-and-zinc-regulate-expression-of-a-putative-abc-metal-transporter-in-corynebacterium-diphtheriae
#14
Eric D Peng, Diana M Oram, Marcos D Battistel, Lindsey R Lyman, Darón I Freedberg, Michael P Schmitt
Corynebacterium diphtheriae , a Gram-positive, aerobic bacterium, is the causative agent of diphtheria and cutaneous infections. While mechanisms required for heme iron acquisition are well known in C. diphtheriae , systems involved in the acquisition of other metals such as zinc and manganese remain poorly characterized. In this study, we identified a genetic region that encodes an ABC-type transporter ( iutBCD ) flanked by two genes ( iutA and iutE ) encoding putative substrate binding proteins of the cluster 9 family, a related group of transporters primarily associated with the import of Mn and Zn...
March 5, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29501062/enhanced-phenolic-compounds-tolerance-response-of-clostridium-beijerinckii-ncimb-8052-by-inactivation-of-cbei_3304
#15
Jun Liu, Qinlu Lin, Xueying Chai, Yunchuan Luo, Ting Guo
BACKGROUND: Phenolic compounds generated in hydrolysis of lignocellulosic materials are major limiting factors for biological production of solvents by Clostridia, but it lacks the attention on the study of adaptation or resistance mechanisms in response to phenolic compounds. RESULTS: Gene Cbei_3304, encoding a hypothetical membrane transport protein, was analyzed by bioinformatic method. After insertional inactivation of the functionally uncertain gene Cbei_3304 in Clostridium beijerinckii NCIMB 8052, resulted in enhanced phenolic compounds tolerance...
March 3, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29485119/root-transcripts-associated-with-arsenic-accumulation-in-hyperaccumulator-pteris-vittata
#16
Rasika M Potdukhe, Priyanka Bedi, Bijaya K Sarangi, Ram A Pandey, Sanjog T Thul
Hyperaccumulation of arsenic (As) by brake fern Pteris vittata has been described as an important genetic trait that provides an option for development of a sustainable phytoremediation process for As mitigation. Accumulation of very high concentration of arsenic in above-ground tissues may be the result of arsenic vacuole compartmentalization, but the mechanism(s) of arsenic uptake and transport by underground tissues are largely unknown. In this study, we made an attempt towards understanding the molecular mechanism of As hyperaccumulation in this plant...
March 2018: Journal of Biosciences
https://www.readbyqxmd.com/read/29483597/regulation-of-age-associated-b-cells-by-irf5-in-systemic-autoimmunity
#17
Michela Manni, Sanjay Gupta, Edd Ricker, Yurii Chinenov, Sung Ho Park, Man Shi, Tania Pannellini, Rolf Jessberger, Lionel B Ivashkiv, Alessandra B Pernis
Age-associated B cells (ABCs) are a subset of B cells dependent on the transcription factor T-bet that accumulate prematurely in autoimmune settings. The pathways that regulate ABCs in autoimmunity are largely unknown. SWAP-70 and DEF6 (also known as IBP or SLAT) are the only two members of the SWEF family, a unique family of Rho GTPase-regulatory proteins that control both cytoskeletal dynamics and the activity of the transcription factor IRF4. Notably, DEF6 is a newly identified human risk variant for systemic lupus erythematosus...
February 26, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29479520/tripartite-atp-independent-periplasmic-trap-transporters-and-tripartite-tricarboxylate-transporters-ttt-from-uptake-to-pathogenicity
#18
REVIEW
Leonardo T Rosa, Matheus E Bianconi, Gavin H Thomas, David J Kelly
The ability to efficiently scavenge nutrients in the host is essential for the viability of any pathogen. All catabolic pathways must begin with the transport of substrate from the environment through the cytoplasmic membrane, a role executed by membrane transporters. Although several classes of cytoplasmic membrane transporters are described, high-affinity uptake of substrates occurs through Solute Binding-Protein (SBP) dependent systems. Three families of SBP dependant transporters are known; the primary ATP-binding cassette (ABC) transporters, and the secondary Tripartite ATP-independent periplasmic (TRAP) transporters and Tripartite Tricarboxylate Transporters (TTT)...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29473496/modulation-of-hepatic-mrp3-abcc3-by-xenobiotics-and-pathophysiological-conditions-role-in-drug-pharmacokinetics
#19
Carolina I Ghanem, Jose E Manautou
Liver transporters play an important role in the pharmacokinetics and disposition of pharmaceuticals, environmental contaminants, and endogenous compounds. Among them, the family of ATP-Binding Cassette (ABC) transporters is the most important due to its role in the transport of endo- and xenobiotics. The ABCC sub-family is the largest one, consisting of 13 members that include the cystic fibrosis conductance regulator (CFTR/ABCC7); the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) and the multidrug resistance-associated proteins (MRPs)...
February 21, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29463238/characterization-and-heterologous-expression-of-the-neoabyssomicin-abyssomicin-biosynthetic-gene-cluster-from-streptomyces-koyangensis-scsio-5802
#20
Jiajia Tu, Siting Li, Jiang Chen, Yongxiang Song, Shaobin Fu, Jianhua Ju, Qinglian Li
BACKGROUND: The deep-sea-derived microbe Streptomyces koyangensis SCSIO 5802 produces neoabyssomicins A-B (1-2) and abyssomicins 2 (3) and 4 (4). Neoabyssomicin A (1) augments human immunodeficiency virus-1 (HIV-1) replication whereas abyssomicin 2 (3) selectively reactivates latent HIV and is also active against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus (MRSA). Structurally, neoabyssomicins A-B constitute a new subtype within the abyssomicin family and feature unique structural traits characteristic of extremely interesting biosynthetic transformations...
February 20, 2018: Microbial Cell Factories
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