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https://www.readbyqxmd.com/read/28944967/risk-for-chromosomal-aberrations-in-apparently-isolated-intra-uterine-growth-restriction-a-systematic-review
#1
REVIEW
Lena Sagi-Dain, Amir Peleg, Shlomi Sagi
OBJECTIVE: To perform a systematic review examining the risk of chromosomal aberrations in apparently isolated intra-uterine growth restriction (IUGR). METHODS: Search was conducted by research librarian in five databases. By independent screening of 2894 references, two investigators selected original studies examining the risk of chromosomal aberrations in apparently isolated IUGR diagnosed at the second and third trimesters using ultrasound. We excluded studies describing IUGR combined with additional fetal anomalies detected by ultrasound and those where fetuses with structural anomalies or aneuploidy were not reported...
September 25, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28944961/two-case-studies-on-how-study-designs-can-be-made-more-informative-using-modeling-and-simulation-approaches
#2
Philip J Lowe, Martin Fink, Mark N Milton
Drug development should extract maximum information from experiments with minimized exposure of patients or experimental animals to invasive procedures and potentially harmful effects with minimized investment of time and money. Herein, two aspects of study design are explored illustrating how information can be extracted more efficiently by investigating a range of exposures within each individual by either following responses as drug concentrations decline or by within-individual dose escalation, rather than relying on steady-state cross-sectional analyses...
September 25, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28944950/comparison-of-unilateral-versus-bilateral-pedicle-screw-fixation-in-transforaminal-lumbar-interbody-fusion-for-single-level-lumbar-degenerative-diseases-and-review-of-literature
#3
Hasan Serdar Işik, Özerk Okutan, Timur Yildirim, Elif Akpinar, Ali Yilmaz
AIM: There are some recognized treatment modalities in the literature for the treatment of lumbar degenerative diseases,which cause pain and avoidance of daily life activities for the patients.The most widely accepted algorithm in the literature is medical treatment,physical therapy and minimally invasive pain-relieving therapies,if necessary,followed by surgical interventions.The common procedure used in neurosurgery practice is the decompression of neural elements followed by fusion...
July 30, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944929/oncogenic-mir%C3%A2-132-sustains-proliferation-and-self%C3%A2-renewal-potential-by-inhibition-of-polypyrimidine-tract%C3%A2-binding-protein-2-in-glioblastoma-cells
#4
Silong Lou, Jia Ji, Xin Cheng, Jian Ruan, Rong Li, Zhengjun Guo
Glioblastoma multiforme (GBM) is the leading type of brain tumor, exhibiting unlimited proliferation and invasion potential. The present study indicated that a high expression level of miR‑132 was detected in the neural subtype of GBM and predicted an unfavorable prognosis for patients from The Cancer Genome Atlas cohort (n=526). Cox hazard regression analysis demonstrated miR‑132 as an independent prognostic indicator for GBM patients. Further in vitro experiments indicated that miR‑132 promoted the proliferation and sphere formation of U87 cells...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944919/proprotein-convertase-subtilisin-kexin-type-6-promotes-in%C3%A2-vitro-proliferation-migration-and-inflammatory-cytokine-secretion-of-synovial-fibroblast%C3%A2-like-cells-from-rheumatoid-arthritis-via-nuclear%C3%A2-%C3%AE%C2%BAb-signal-transducer-and-activator-of-transcription-3-and
#5
Huiyu Jiang, Lin Wang, Feifei Wang, Jihong Pan
Our previous studies demonstrated that expression of proprotein convertase subtilisin/kexin type 6 (PCSK6) is greatly enhanced in rheumatoid arthritis fibroblast‑like synoviocytes (RASFs), and that PCSK6 inhibition decreases cell proliferation, migration and invasion. The present study aimed to investigate the functional role of PCSK6 in the hyperplasia of RASFs. Cultured RASFs from RA patients were stimulated with recombinant human (rh)PCSK6. Subsequent changes in proliferation, invasion, migration and the secretion of inflammatory cytokines were measured in vitro using MTT, wound healing and Transwell assays, and ELISA...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944918/microrna%C3%A2-340-inhibits-tumor-cell-proliferation-migration-and-invasion-and-induces-apoptosis-in-hepatocellular-carcinoma
#6
Ziyao Wang, Dan Song, Ping Huang
MicroRNAs (miRs) are short RNAs that serve a role in the origination and progression of hepatocellular carcinoma (HCC). miR‑340 has been identified to be a novel tumor suppressor. The present study investigated the antitumor function of miR‑340 in HCC. In the present study, it was detected that miR‑340 was significantly decreased in HCC cancer tissues and human HCC cell lines using reverse transcription‑quantitative polymerase chain reaction analysis. Cell Counting kit‑8 and apoptosis assays demonstrated that miR‑340 reduced cell proliferation and induced cellular apoptosis in HCC cell lines...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944896/microrna%C3%A2-186-targets-igf%C3%A2-1r-and-exerts-tumor%C3%A2-suppressing-functions-in-glioma
#7
Jian Jiang, Weijie Wang, Dazhao Fang, Xiaodong Jin, Lianshu Ding, Xiaoyang Sun
Glioma is the most common malignant brain tumor in adults and represents one of the most aggressive and life‑threatening types of cancer in humans. Increasing studies have revealed that microRNAs are abnormally expressed in various types of human cancer, and have oncogenic or tumor suppressive roles, which depend primarily on the type of cancer. The present study aimed to investigate the expression level and effects of microRNA‑186 (miR‑186) on glioma, and its underlying molecular mechanism. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis was performed to detect the expression of miR‑186 in glioma tissues and cell lines...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944890/paeonol-exerts-potential-activities-to-inhibit-the-growth-migration-and-invasion-of-human-gastric-cancer-bgc823-cells-via-downregulating-mmp%C3%A2-2-and-mmp%C3%A2-9
#8
Zhong-Kuan Lyu, Chang-Ling Li, Yan Jin, Yu-Zhao Liu, Xi Zhang, Fang Zhang, Lu-Ning Ning, Er-Shun Liang, Min Ma, Wei Gao, Ming-Xiang Zhang, De-Shan Liu
Paeonol (Pae) is an herbal extract that has attracted extensive attention for its anti‑cancer effects demonstrated by a number of studies, which have predominantly demonstrated inhibition of cell proliferation and induction of apoptosis. The influence of Pae on cancer cell metastasis has been less widely reported. The present study aimed to investigate the under‑reported effects of Pae on the growth, invasion and migration of poorly differentiated BGC823 gastric cancer cells with strong invasive and metastatic abilities...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944887/microrna%C3%A2-212-inhibits-colorectal-cancer-cell-viability-and-invasion-by-directly-targeting-pik3r3
#9
Jian Zhang, Yongkang Zhang, Xiaoyun Li, Hongbo Wang, Quan Li, Xiaofeng Liao
Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer‑associated mortalities worldwide. Emerging evidence has shown that abnormal microRNA (miRNA) expression contributes to CRC carcinogenesis and progression by inhibiting the expression of their target genes. Therefore, investigating the expression patterns and roles of miRNAs specifically involved in CRC formation, and progression would help expand our knowledge on CRC and provide novel therapeutic targets for CRC treatment...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944877/sparcl1-suppresses-cell-migration-and-invasion-in-renal-cell-carcinoma
#10
Hui Ye, Wei-Gang Wang, Jun Cao, Xi-Chun Hu
Previous studies have shown that the human SPARC‑like 1 (SPARCL1) is crucial for human cancer migration and invasion. In the present study, the expression, biological function and possible molecular regulatory mechanisms of SPARCL1 were investigated in human renal cell carcinoma (RCC). The protein expression of SPARCL1 in cells was evaluated using western blot analysis and immunohistochemical staining in the tissue microarray. The effects of SPARCL1 on the biological behaviors of RCC cells were assessed using in vitro assays...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944863/microrna%C3%A2-509-acts-as-a-tumor-suppressor-in-tongue-squamous-cell-carcinoma-by-targeting-epidermal-growth-factor-receptor
#11
Chao Hou, Yan Dong, Fenghe Zhang, Bo Du
Tongue squamous cell carcinoma (TSCC) is the most frequent type of oral carcinoma, and is characterized by high metastatic and growth capabilities. Previous studies have demonstrated that aberrantly expressed cancer‑associated microRNAs (miRs) may be associated with tumorigenesis and tumor development in various types of cancer, including TSCC. miR‑509 has been identified as a critical regulator in tumorigenesis and tumor development, via its tumor‑suppressing actions in several types of human cancer...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944853/kisspeptin-inhibits-cancer-growth-and-metastasis-via-activation-of-eif2ak2
#12
Tae-Hun Kim, Sung-Gook Cho
Kisspeptin is a protein encoded by the KISS1 gene, which has been reported to suppress the metastatic capabilities of various types of cancer cells, through the activation of its G‑protein coupled receptor GPR54. However, the molecular mechanisms underlying the involvement of kisspeptin‑mediated signaling in the inhibition of cancer cell migration and invasion have yet to be elucidated. The present in vitro cell proliferation, migration and invasion assays and in vivo experimental metastasis studies demonstrated that kisspeptin‑induced eukaryotic translation initiation factor 2α kinase 2 (EIF2AK2) activation suppressed the metastatic capabilities of several types of cancer cells...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944846/hedyotis-diffusa-willd-suppresses-metastasis-in-5%C3%A2-fluorouracil%C3%A2-resistant-colorectal-cancer-cells-by-regulating-the-tgf%C3%A2-%C3%AE-signaling-pathway
#13
Zijun Lai, Zhaokun Yan, Wujin Chen, Jun Peng, Jianyu Feng, Qiongyu Li, Yiyi Jin, Jiumao Lin
Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract, and threatens the survival and health of patients with CRC. Chemotherapy remains one of the main therapeutic approaches for patients with CRC; however, drug resistance limits the long‑term use. CRC cells with multi‑drug resistance (MDR) exhibit increased survival times and metastatic potential, which may lead to the recurrence and metastasis of CRC. In addition, MDR is one of the major causes of chemotherapy failure in clinical treatment...
September 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944839/alteration-of-oxidative-stress-and-inflammatory-cytokines-induces-apoptosis-in-diabetic-nephropathy
#14
Jibin Sha, Bo Sui, Xiaoqing Su, Qingfang Meng, Chenggang Zhang
Diabetic nephropathy (DN) is one of the most significant long‑term complications in terms of morbidity and mortality for diabetic patients; however, the exact cause remains unknown. To address this, the DN model was established, and oxidative stress indexes, including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH‑Px), and inflammatory cytokines, includinginterleukin‑6 (IL‑6), tumor necrosis factor‑alpha (TNF‑α) and transforming growth factor‑beta (TGF‑β), were examined by ELISA...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944826/macc%C3%A2-1-antibody-target-therapy-suppresses-growth-and-migration-of-non%C3%A2-small-cell-lung-cancer
#15
Woda Shi, Jianxiang Song, Wencai Wang, Yajun Zhang, Shiying Zheng
Non‑small‑cell lung cancer (NSCLC) accounts for ~80% of human lung cancers that result in mortalities worldwide. Metastasis‑associated in colon cancer‑1 (MACC‑1) has been demonstrated to be significantly expressed in cases of NSCLC and promotes tumor cell migration and metastasis through transactivation of the metastasis‑inducing hepatocyte growth factor/MET proto‑gene, receptor tyrosine kinase (HGF/MET) signaling pathway. The present study constructed a chimeric antibody (Chanti‑MACC‑1) targeting MACC‑1 and investigated its potential as a molecular therapeutic target in the treatment of NSCLC therapy...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944782/perioperative-cerebrospinal-fluid-drainage-for-the-prevention-of-spinal-ischemia-after-endovascular-aortic-repair
#16
M Wortmann, D Böckler, P Geisbüsch
Endovascular treatment of thoracic and thoracoabdominal aortic diseases is accompanied by a risk of spinal ischemia in 1-19% of patients, depending on the entity and extent of the disease. The use of perioperative drainage of cerebrospinal fluid is one of the invasive measures to reduce the occurrence of this severe complication. This article reviews the incidence of spinal ischemia, its risk factors, the evidence for carrying out cerebrospinal fluid drainage and its modern use by means of an automated, pressure controlled system (LiquoGuard®7)...
2017: Gefässchirurgie: Zeitschrift Für Vaskuläre und Endovaskuläre Chirurgie
https://www.readbyqxmd.com/read/28944750/microsporidia-obligate-intracellular-pathogens-within-the-fungal-kingdom
#17
Bing Han, Louis M Weiss
Microsporidia are obligate intracellular pathogens related to Fungi. These organisms have a unique invasion organelle, the polar tube, which upon appropriate environmental stimulation rapidly discharges out of the spore, pierces a host cell's membrane, and serves as a conduit for sporoplasm passage into the host cell. Phylogenetic analysis suggests that microsporidia are related to the Fungi, being either a basal branch or sister group. Despite the description of microsporidia over 150 years ago, we still lack an understanding of the mechanism of invasion, including the role of various polar tube proteins, spore wall proteins, and host cell proteins in the formation and function of the invasion synapse...
April 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28944617/genetic-diversity-anti-microbial-resistance-plasmid-profile-and-frequency-of-the-vi-antigen-in-salmonella-dublin-strains-isolated-in-brazil
#18
F P Vilela, M R Frazão, D P Rodrigues, R G Costa, M R T Casas, S A Fernandes, J P Falcão, F Campioni
Salmonella Dublin is strongly adapted to cattle causing enteritis and/or systemic disease with high rates of mortality. However, it can be sporadically isolated from humans, usually causing serious disease, especially in patients with underlying chronic diseases. The aim of this study was to molecularly type S. Dublin strains isolated from humans and animals in Brazil to verify the diversity of these strains as well as to ascertain possible differences between strains isolated from humans and animals. Moreover, the presence of the capsular antigen Vi and the plasmid profile was characterized in addition to the anti-microbial resistance against 15 drugs...
September 24, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28944558/imaging-the-neuroimmune-response-to-alcohol-exposure-in-adolescent-baboons-a-tspo-pet-study-using-18-f-dpa-714
#19
Wadad Saba, Sébastien Goutal, Sylvain Auvity, Bertrand Kuhnast, Christine Coulon, Virginie Kouyoumdjian, Irène Buvat, Claire Leroy, Nicolas Tournier
The effects of acute alcohol exposure to the central nervous system are hypothesized to involve the innate immune system. The neuroimmune response to an initial and acute alcohol exposure was investigated using translocator protein 18 kDa (TSPO) PET imaging, a non-invasive marker of glial activation, in adolescent baboons. Three different alcohol-naive adolescent baboons (3-4 years old, 9 to 14 kg) underwent (18) F-DPA-714 PET experiments before, during and 7-12 months after this initial alcohol exposure (0...
September 25, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28944501/synergistic-effects-of-interferon-beta-and-nivolumab-in-oral-mucosal-melanoma
#20
Takayuki Fusumae, Koji Kamiya, Binluen Chiang, Hirofumi Okada, Naomi Nakano, Takeo Maekawa, Mayumi Komine, Satoru Murata, Mamitaro Ohtsuki
Mucosal melanoma is a rare aggressive cancer with a very poor prognosis. Clinical and pathological characteristics of mucosal melanoma differ from those of cutaneous melanoma and there are no established management guidelines for mucosal melanoma. Complete surgical excision is one of the most effective treatments for localized lesions, while targeted therapies and immunotherapies, such as monoclonal antibodies that target cytotoxic T-lymphocyte-associated molecule-4, and the programmed death (PD)-1/PD-ligand 1 pathway inhibitors, are treatment options for unresectable or metastatic lesions...
September 25, 2017: Journal of Dermatology
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