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https://www.readbyqxmd.com/read/29149385/pre-clinical-models-in-pediatric-traumatic-brain-injury-challenges-and-lessons-learned
#1
REVIEW
Patrick M Kochanek, Jessica S Wallisch, Hülya Bayır, Robert S B Clark
PURPOSE: Despite the enormity of the problem and the lack of new therapies, research in the pre-clinical arena specifically using pediatric traumatic brain injury (TBI) models is limited. In this review, some of the key models addressing both the age spectrum of pediatric TBI and its unique injury mechanisms will be highlighted. Four topics will be addressed, namely, (1) unique facets of the developing brain important to TBI model development, (2) a description of some of the most commonly used pre-clinical models of severe pediatric TBI including work in both rodents and large animals, (3) a description of the pediatric models of mild TBI and repetitive mild TBI that are relatively new, and finally (4) a discussion of challenges, gaps, and potential future directions to further advance work in pediatric TBI models...
October 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29145961/vertical-femoral-neck-fractures-in-young-adults-a-closed-fixation-strategy-using-a-transverse-cancellous-lag-screw
#2
João Antonio Matheus Guimarães, Leonardo Rosa Rocha, Tito Henrique Noronha Rocha, Danielle Cabral Bonfim, Rafaela Sartore da Costa, Amanda Dos Santos Cavalcanti, Carlos Rodrigo Roesler, Jamila Alessandra Perini Machado, Diego Pinheiro Aguiar, Maria Eugenia Leite Duarte
Vertical femoral neck fractures (Pauwels type III classification) in young adults generally occur as a consequence of high-energy trauma and are frequently seen in association with multiple injuries. Considering the controversies regarding the optimal fixation for this fracture, our aim was to evaluate the clinical outcome of a closed fixation strategy for vertical femoral neck fractures in young adults using two parallel and one transverse cancellous lag screws. This was a single-surgeon, prospective study including 20 young adults with average age of 38...
October 2017: Injury
https://www.readbyqxmd.com/read/29132064/patients-and-caregivers-contributions-for-differentiating-epileptic-from-psychogenic-nonepileptic-seizures-value-and-limitations-of-self-reporting-questionnaires-a-pilot-study
#3
Giuseppe Erba, Elisa Bianchi, Giorgia Giussani, John Langfitt, Adam Juersivich, Ettore Beghi
PURPOSE: Questionnaires investigating semiology and comorbidities of psychogenic non-epileptic seizures (PNES) have been used mainly to help physicians expedite referrals to epilepsy centres for confirmation of diagnosis rather than as alternative diagnostic tool when video-EEG monitoring (VEM), the current gold standard, is not available or is inconclusive. METHODS: We developed one structured questionnaire for patients, exploring subjective experiences and vulnerabilities and one for eyewitnesses, focused on features observable during typical events to study prospectively 50 consecutive adult patients with PNES or epileptic seizures (ES) admitted for VEM...
November 8, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29128850/exploring-the-newborn-head-diameters-in-relation-to-current-obstetric-forceps-dimensions-a-systematic-review
#4
Abdul-Qader T Ismail, Derick Yates, Jonathan Chester, Khaled M K Ismail
OBJECTIVE: The aim of this study was to systematically search the literature for studies that reported term neonate head size and shape, in an attempt to determine the most appropriate dimensions for the obstetric forceps. STUDY DESIGN: We searched the Ovid Medline, Ovid Embase and Ebscohost CINAHL databases from inception to February 2016. We predefined inclusion criteria to identify studies in which head width and length of asymptomatic, term neonates were measured soon after birth using direct, non-photographic methods A bespoke quality assessment score was used to evaluate the identified studies...
October 28, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29121834/head-injuries-in-urban-environment-skiing-and-snowboarding-a-retrospective-study-on-injury-severity-and-injury-mechanisms
#5
A Stenroos, L Handolin
BACKGROUND AND AIM: During the last decade urban skiing and snowboarding has gained a lot of popularity. In urban skiing/snowboarding riders try to balance on handrails and jump off buildings. Previous studies in skiing and snowboarding accidents have mostly been conducted at hospitals located close to alpine terrain with big ski resort areas. The aim of this study is to evaluate the types and severity of traumatic brain injuries occurring in small, suburban hills and in urban environment, and to characterize injury patterns to find out the specific mechanisms of injuries behind...
November 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29114772/development-of-a-single-degree-of-freedom-mechanical-model-for-predicting-strain-based-brain-injury-responses
#6
Lee F Gabler, Hamed Joodaki, Jeff R Crandall, Matthew B Panzer
Linking head impact kinematics to injury risk has been the focus of numerous brain injury criteria. Although many early forms were developed using mechanics principles, recent criteria have been developed using empirical methods based on subsets of head impact data. In this study, a single-degree-of-freedom (sDOF) mechanical analogue was developed to study the link between rotational head kinematics and brain deformation. Model efficacy was assessed by comparing its dynamic response to strain-based brain injury predictors from finite element (FE) human head models...
November 6, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29090361/long-term-disabilities-after-traumatic-head-injury-thi-a-retrospective-analysis-from-a-large-level-i-trauma-center-in-saudi-arabia
#7
Suliman Alghnam, Alaa AlSayyari, Ibrahim Albabtain, Bader Aldebasi, Mohamed Alkelya
BACKGROUND: Traumatic head injuries (THI) are a critical public health problem worldwide, with more than 10 million individuals affected every year. In Saudi Arabia (SA), the burden of THI is unknown even though injury is the leading cause of death and a major cause of disability. Therefore, we aim to estimate the prevalence of long-term of disabilities among survivors of THI treated at a large level-I trauma center in Riyadh. METHODS: The study included 258 patients, who were hospitalized due to a non-fatal THI between years 2005-2014...
November 1, 2017: Injury Epidemiology
https://www.readbyqxmd.com/read/29084105/intracranial-pathology-ct-in-emergency-department-patients-with-high-gcs-and-high-standard-assessment-of-concussion-sac-scores
#8
Kenneth C Curley, Brian J OʼNeil, Rosanne Naunheim, David W Wright
OBJECTIVE: To demonstrate that a subpopulation of patients with mild/moderate traumatic brain injury (TBI) had intracranial pathology despite having a Glasgow Coma Scale (GCS) score of 15 and a Standardized Assessment of Concussion (SAC) score of 25 or higher. SETTING: A network of 11 US emergency departments (ED) enrolling patients in a multisite study of TBI. PARTICIPANTS: Men and women between the ages of 18 and 85 years admitted to a participating ED having sustained a closed head injury within the prior 72 hours and a GCS score of 13 to 15 at the time of enrollment...
October 27, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/29043546/compensatory-reserve-weighted-intracranial-pressure-and-its-association-with-outcome-after-traumatic-brain-injury
#9
L Calviello, J Donnelly, D Cardim, C Robba, F A Zeiler, P Smielewski, M Czosnyka
OBJECTIVE: We introduced 'compensatory-reserve-weighted intracranial pressure (ICP),' named 'weightedICP' for brevity, as a variable that may better describe changes leading to mortality after traumatic brain injury (TBI) over the standard mean ICP. METHODS: ICP was monitored prospectively in over 1023 sedated and ventilated patients. The RAP coefficient (R-correlation, A-amplitude, and P-pressure) was calculated as the running correlation coefficient between slow changes in the pulse amplitude of ICP and the mean ICP...
October 17, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/29030385/long-term-follow-up-after-bilateral-percutaneous-epiphysiodesis-around-the-knee-to-reduce-excessive-predicted-final-height
#10
Wesley J Goedegebuure, Frank Jonkers, Annemieke M Boot, Willie M Bakker-van Waarde, Vera van Tellingen, Minne Heeg, Roelof J Odink, Florens van Douveren, Arnold T Besselaar, Marieke C van der Steen
CONTEXT: Percutaneous epiphysiodesis (PE) around the knee to reduce predicted excessive final height. Studies until now included small numbers of patients and short follow-up periods. OBJECTIVE AND DESIGN: This Dutch multicentre, long-term, retrospective, follow-up study aimed to assess adult height (AH), complications, knee function and patient satisfaction after PE. The primary hypothesis was that PE around the knee in constitutionally tall boys and girls is an effective treatment for reducing final height with low complication rates and a high level of patient satisfaction...
October 13, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29021905/the-waterpolo-shoulder-paradigm-results-of-ultrasound-surveillance-at-poolside
#11
Felice Galluccio, Eleonora Bellucci, Francesco Porta, Lorenzo Tofani, Amato De Paulis, Diana Bianchedi, Tatiana Barskova, Marco Matucci-Cerinic
BACKGROUND: Waterpolo consists of a combination of swimming and throwing with close contact between players. The shoulder is the most frequently injured joint, with a combination of rotator cuff tear and tendinopathy, long head biceps tendinopathy, superior labral lesions and shoulder impingement. This unique combination is a challenge for the clinician who must determine which of these shoulder pathologies is responsible for the onset of pain and the best strategy to rehabilitate the joint and prevent recurrence...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28981349/hearing-complaints-among-veterans-following-traumatic-brain-injury
#12
Frederick J Gallun, Melissa A Papesh, M Samantha Lewis
It has been shown that there is an increased risk for impaired auditory function following traumatic brain injury (TBI) in Veterans. Evidence is strongest in the area of self-report, but behavioural and electrophysiological data have been obtained that are consistent with these complaints. Peripheral and central dysfunction have both been observed. Historically, studies have focused on penetrating head injuries where central injury is more easily documented than in mild closed head injuries, but several recent reports have expanded the literature to include closed head injuries as well...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28966972/defining-an-analytic-framework-to-evaluate-quantitative-mri-markers-of-traumatic-axonal-injury-preliminary-results-in-a-mouse-closed-head-injury-model
#13
M Haber, E B Hutchinson, N Sadeghi, W H Cheng, D Namjoshi, P Cripton, M O Irfanoglu, C Wellington, R Diaz-Arrastia, C Pierpaoli
Diffuse axonal injury (DAI) is a hallmark of traumatic brain injury (TBI) pathology. Recently, the Closed Head Injury Model of Engineered Rotational Acceleration (CHIMERA) was developed to generate an experimental model of DAI in a mouse. The characterization of DAI using diffusion tensor magnetic resonance imaging (MRI; diffusion tensor imaging, DTI) may provide a useful set of outcome measures for preclinical and clinical studies. The objective of this study was to identify the complex neurobiological underpinnings of DTI features following DAI using a comprehensive and quantitative evaluation of DTI and histopathology in the CHIMERA mouse model...
September 2017: ENeuro
https://www.readbyqxmd.com/read/28941507/management-of-zygomaticomaxillary-complex-fractures
#14
REVIEW
E Bradley Strong, Celeste Gary
Zygomaticomaxillary fractures account for approximately 25% of all facial fractures. They can be grouped into high-velocity and low-velocity injuries. A complete head and neck examination is critical for accurate clinical diagnosis. A thin-cut axial CT scan with sagittal, coronal, and 3-D reconstruction is important for accurate diagnosis and treatment planning. A thorough understanding of bony tetrapod anatomy and fracture mechanics is critical to treatment planning. Treatment options include closed and open reduction with internal fixation...
November 2017: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/28941502/neurosurgical-considerations-in-craniofacial-trauma
#15
REVIEW
Robert Glenn Oxford, Randall Matther Chesnut
Spinal and traumatic brain injuries (TBIs) often accompany craniofacial trauma. Neurosurgical considerations can range from initial emergent surgery to conservative management of closed head injuries in patients with craniofacial injuries. This article discusses the most common disorders managed by neurosurgeons in the setting of craniofacial trauma, and reviews the usual timing and setting for various treatments that patients with TBI encounter throughout the course of treatment. It also highlights the consequences of TBI on the timing and planning of craniofacial repairs and the importance of multidisciplinary cooperation to provide comprehensive care to survivors of trauma...
November 2017: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/28937299/pediatric-playground-related-injuries-treated-in-hospital-emergency-departments-in-the-united-states
#16
Sarah L Adelson, Thitphalak Chounthirath, Nichole L Hodges, Christy L Collins, Gary A Smith
This study analyzed pediatric playground-related injuries data from the National Electronic Injury Surveillance System. An estimated 5 025 440 children <18 years were treated in US emergency departments for playground-related injuries during 1990-2012, averaging 218 497 children annually. The average patient age was 6.5 years. The overall annual injury rate declined during 1990-2007 ( P < .001) and then increased during 2007-2012 ( P < .001). The climbing equipment-related injury rate remained constant during 1990-2009 and then increased during 2007-2012 ( P = ...
September 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28936067/external-validation-of-the-rotterdam-computed-tomography-score-in-the-prediction-of-mortality-in-severe-traumatic-brain-injury
#17
Jose D Charry, Jesus D Falla, Juan D Ochoa, Miguel A Pinzón, Jorman H Tejada, Maria J Henriquez, Juan Pablo Solano, Camilo Calvache
INTRODUCTION: Traumatic brain injury (TBI) is a public health problem. It is a pathology that causes significant mortality and disability in Colombia. Different calculators and prognostic models have been developed to predict the neurological outcomes of these patients. The Rotterdam computed tomography (CT) score was developed for prognostic purposes in TBI. We aimed to examine the accuracy of the prognostic discrimination and prediction of mortality of the Rotterdam CT score in a cohort of trauma patients with severe TBI in a university hospital in Colombia...
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28933213/repeated-mild-traumatic-brain-injury-potential-mechanisms-of-damage
#18
Brooke Fehily, Melinda Fitzgerald
Mild traumatic brain injury (mTBI) represents a significant public healthcare concern, accounting for the majority of all head injuries. While symptoms are generally transient, some patients go on to experience long-term cognitive impairments and additional mild impacts can result in exacerbated and persisting negative outcomes. To date, studies using a range of experimental models have reported chronic behavioral deficits in the presence of axonal injury and inflammation following repeated mTBI; assessments of oxidative stress and myelin pathology have thus far been limited...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28924145/a-novel-mouse-model-of-traumatic-optic-neuropathy-using-external-ultrasound-energy-to-achieve-focal-indirect-optic-nerve-injury
#19
Wensi Tao, Galina Dvoriantchikova, Brian C Tse, Steven Pappas, Tsung-Han Chou, Manuel Tapia, Vittorio Porciatti, Dmitry Ivanov, David T Tse, Daniel Pelaez
Traumatic optic neuropathy (TON) is a devastating cause of permanent visual loss following blunt injury to the head. Animal models for TON exist, but most fail to recapitulate the clinical scenario of closed head indirect trauma to the nerve and subsequent neurodegeneration. Thus, we developed a clinically-relevant animal model for TON using a novel ultrasonic pulse injury modality (sonication-induced TON; SI-TON). To trigger TON, a microtip probe sonifier was placed on the supraorbital ridge directly above the entrance of the optic nerve into the bony canal...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28904564/the-role-of-pre-reduction-mri-in-the-management-of-complex-cervical-spine-fracture-dislocations-an-ongoing-controversy
#20
Sergiu Botolin, Todd F VanderHeiden, Ernest E Moore, Herbert Fried, Philip F Stahel
BACKGROUND: Cervical spine fracture-dislocations in neurologically intact patients represent a surgical challenge due to the risk of inflicting iatrogenic spinal cord compression by closed reduction maneuvers. The use of MRI for early advanced imaging in these injuries remains controversially debated. CASE PRESENTATION: A 54-year old man sustained a fall over the handlebars of his racing bicycle. The helmeted patient sustained a fall on his head which resulted in a hyperflexion injury of the neck...
2017: Patient Safety in Surgery
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