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https://www.readbyqxmd.com/read/29330386/on-the-detection-of-cerebral-metabolic-depression-in-experimental-traumatic-brain-injury-using-chemical-exchange-saturation-transfer-cest-weighted-mri
#1
Tsang-Wei Tu, Wael G Ibrahim, Neekita Jikaria, Jeeva P Munasinghe, Jaclyn A Witko, Dima A Hammoud, Joseph A Frank
Metabolic abnormalities are commonly observed in traumatic brain injury (TBI) patients exhibiting long-term neurological deficits. This study investigated the feasibility and reproducibility of using chemical exchange saturation transfer (CEST) MRI to detect cerebral metabolic depression in experimental TBI. Phantom and in vivo CEST experiments were conducted at 9.4 Tesla to optimize the selective saturation for enhancing the endogenous contrast-weighting of the proton exchanges over the range of glucose proton chemical shifts (glucoCEST) in the resting rat brain...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29318344/severe-casualties-from-bastille-day-attack-in-nice-france
#2
Federico Solla, Joseph Carboni, Arnaud Fernandez, Audrey Dupont, Nathalie Chivoret, Gilles Brézac, Virginie Rampal, Jean Bréaud
PURPOSE: To describe the most severe casualties from the July 14th, 2016 terror attack in Nice that were treated at the Lenval University Children's Hospital (LUCH) of Nice (France). METHODS: Retrospective study about casualties treated at LUCH from Bastille Day Attack with injuries resulting in the need for surgery, resuscitation, or death. The type of lesions and surgery, duration of hospitalizations, complications, psychological status, and outcome at discharge were collected...
January 9, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29317223/cluster-analysis-of-vulnerable-groups-in-acute-tbi-rehabilitation
#3
Erkut N Kucukboyaci, Coralynn Long, Michelle Smith, Joseph F Rath, Tamara Bushnik
OBJECTIVE: To analyze the complex relationship between various social indicators that contribute to socioeconomic status and healthcare barriers. DESIGN: Cluster analysis of historical patient data obtained from inpatient visits. SETTING: Setting: Inpatient rehabilitation unit in a large, urban university hospital PARTICIPANTS: Adult patients receiving acute inpatient care, predominantly for closed head injury. INTERVENTIONS: Not applicable MAIN OUTCOME MEASURES: We examined the membership of TBI patients in various "vulnerable group" (VG) clusters (e...
January 6, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29303438/prospective-randomized-blinded-and-placebo-controlled-study-of-cerebrolysin-dose-response-effects-on-long-term-functional-outcomes-in-a-rat-model-of-mild-traumatic-brain-injury
#4
Yanlu Zhang, Michael Chopp, Zheng Gang Zhang, Yi Zhang, Li Zhang, Mei Lu, Talan Zhang, Stefan Winter, Hemma Brandstätter, Asim Mahmood, Ye Xiong
OBJECTIVE Cerebrolysin is a neuropeptide preparation that mimics the properties of neurotrophic factors and has had beneficial effects in the treatment of neurodegenerative diseases, stroke, and traumatic brain injury (TBI). To further evaluate treatment schemes, the authors assessed the dose-response of Cerebrolysin on functional improvement in a rat model of mild TBI (mTBI). METHODS This dose-response study was a prospective, randomized, blinded, and placebo-controlled preclinical experiment. Male Wistar adult rats, subjected to mTBI induced by a closed head impact, were treated randomly with 0 (saline as placebo), 0...
January 5, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29291295/radial-to-axillary-nerve-transfer
#5
Vicente Vanaclocha, Juan Manuel Herrera, Marlon Rivera-Paz, Deborah Martínez-Gómez, Leyre Vanaclocha
Axillary nerve injury is common after brachial plexus injuries, particularly with shoulder luxation. Nerve grafting is the traditional procedure for postganglionic injuries. Nerve transfer is emerging as a viable option particularly in late referrals. At the proximal arm the radial and axillary nerves lie close by. Sacrificing one of the triceps muscle nerve branches induces little negative consequences. Transferring the long head of the triceps nerve branch is a good option to recover axillary nerve function...
January 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29283153/bilateral-medial-rectus-palsy-due-to-midbrain-infarction-following-concussion-head-injury
#6
Hansa H Thakkar, Apeksha Agrawal, Stuti Trivedi, Kartikey Singh
Here, we report a rare case of bilateral medial rectus palsy following closed head injury. An adult male had an accidental fall which rendered him unconscious. This was followed by diplopia and restricted ocular motility. He received supportive medical therapy. He was examined for systemic medical and ophthalmic findings. Routine laboratory tests and imaging techniques were employed as per the symptoms. Diffusion-weighted imaging on magnetic resonance imaging proved it to be a rare presentation of small bilateral midbrain infarct...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29251705/human-adipose-derived-stem-cell-asc-treatment-modulates-cellular-protection-in-both-in-vitro-and-in-vivo-traumatic-brain-injury-models
#7
Nikolas S Kappy, Shaohua Chang, William M Harris, Michael Plastini, Telisha Ortiz, Ping Zhang, Joshua P Hazelton, Jeffrey P Carpenter, Spencer A Brown
BACKGROUND: Traumatic brain injury (TBI) is a common cause of morbidity and mortality in the civilian population. The purpose of this study is to examine the effect(s) of ASC treatment on cellular and functional recovery in TBI via both in vitro and in vivo methods. METHODS: Cultured neuroblastoma cells, SH-SY5Y, were scratched to mimic TBI in an in vitro model. The effect of ASC conditioned medium on cell death, mitochondrial function, and expression of inflammatory cytokines (TNF-α, IL-1β and IL-6) as well as apoptosis marker FAS was measured...
December 14, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29244684/open-hip-dislocation-through-the-scrotum-without-osseous-injury-a-case-report
#8
Tyler Snoap, Jason Habeck, Jason Roberts
CASE: A 36-year-old bicyclist sustained an open anterior hip dislocation through the scrotum after being struck by 2 motor vehicles. There was no osseous injury present. The hip was irreducible by closed means and required open reduction via a Smith-Petersen approach. Postoperatively, the patient did not develop osteonecrosis of the femoral head but did have signs of mild osteoarthritis and heterotopic ossification. CONCLUSION: Open anterior hip dislocation into the scrotum is an exceedingly rare injury...
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29242788/obturator-dislocation-of-hip-with-ipsilateral-fracture-neck-femur-a-case-report
#9
Sumit Kumar Jain, Parit Aggarwal, Arun Yadav
Introduction: Traumatic dislocation of the hip with ipsilateral fracture neck femur is a rare injury because of the different mechanism of both these injuries. The management of such injuries is a challenge as the chances of nonunion and avascular necrosis of femoral head are very high with fixation methods. We report a case of obturator dislocation of the hip with ipsilateral fracture neck of the femur which was treated with uncemented total hip replacement. Case Report: A 32-year-old male sustained obturator dislocation with ipsilateral fracture neck femur following road traffic accident...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29215378/developing-resident-sensitive-quality-measures-a-model-from-pediatric-emergency-medicine
#10
Daniel J Schumacher, Eric S Holmboe, Cees van der Vleuten, Jamiu O Busari, Carol Carraccio
PURPOSE: To begin closing the gap with respect to quality measures available for use among residents, the authors sought to identify and develop resident-sensitive quality measures (RSQMs) for use in the pediatric emergency department (PED) setting. METHOD: In May 2016, the authors reviewed National Quality Measures Clearinghouse (NQMC) measures to identify resident-sensitive measures. To create additional measures focused on common, acute illnesses (acute asthma exacerbation, bronchiolitis, closed head injury [CHI]) in the PED, the authors used a nominal group technique (NGT) and Delphi process from September to December 2016...
December 5, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29201574/penetrating-orbital-injuries-a-review
#11
REVIEW
Faizullah Mashriqi, Joe Iwanaga, Marios Loukas, Anthony V D'Antoni, R Shane Tubbs
Penetrating injuries to the orbit represent a small but very complicated portion of head injuries. Because of the close proximity to many vital structures, any penetrating orbital injury requires a multidisciplinary follow-up. Cases of penetrating injuries have flooded the literature, but no one has presented a systematic approach to the complications associated with these types of injuries. Herein, we present the complications associated with each orbital entry mode: superior, inferior, medial, lateral rims of the orbit, and extraorbital entry...
September 29, 2017: Curēus
https://www.readbyqxmd.com/read/29193043/the-role-of-negative-affect-on-headache-related-disability-following-traumatic-physical-injury
#12
Maria L Pacella, Bryce Hruska, Richard L George, Douglas L Delahanty
OBJECTIVE: Acute postinjury negative affect (NA) may contribute to headache pain following physical injury. Early psychiatric-headache comorbidity conveys increased vulnerability to chronic headache-related disability and impairment. Yet, it is unknown whether NA is involved in the transition to chronic headache related-disability after injury. This prospective observational study examined the role of acute postinjury NA on subacute and chronic headache-related disability above and beyond nonpsychiatric factors...
November 28, 2017: Headache
https://www.readbyqxmd.com/read/29190159/performance-of-bio-occlusive-dressing-as-barrier-protection-from-presurgical-chlorhexidine-skin-preparation
#13
Frank Brodie, Gregory Bever, David G Hwang
Purpose/Aim of the study: Chlorhexdine has been shown to provide excellent and cost-effective presurgical antisepsis. However, standard presurgical concentrations of chlorhexidine (2-4%) are known to cause ocular injury, even in cases in which a bio-occlusive dressing (Tegaderm™) was applied beforehand to the closed eye. MATERIALS AND METHODS: Three experiments were conducted to assess the barrier performance of Tegaderm™ to chlorhexidine skin prep in vitro and on non-ocular skin...
November 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29189531/characterization-of-american-football-injuries-in-children-and-adolescents
#14
Patrick J Smith, Anthony M Hollins, Jeffrey R Sawyer, David D Spence, Shane Outlaw, Derek M Kelly
BACKGROUND: As a collision sport, football carries a significant risk of injury, as indicated by the large number of pediatric football-related injuries seen in emergency departments. There is little information in the medical literature focusing on the age-related injury patterns of this sport. Our purpose was to evaluate the types of football-related injuries that occur in children and adolescents and assess which patient characteristics, if any, affect injury pattern. METHODS: Retrospective chart review was performed of football-related injuries treated at a level 1 pediatric referral hospital emergency department and surrounding urgent care clinics between January 2010 and January 2014...
November 16, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29187863/smooth-an-hnrnp-l-homolog-might-decrease-mitochondrial-metabolism-by-post-transcriptional-regulation-of-isocitrate-dehydrogenase-idh-and-other-metabolic-genes-in-the-sub-acute-phase-of-traumatic-brain-injury
#15
Arko Sen, Katherine Gurdziel, Jenney Liu, Wen Qu, Oluwademi O Nuga, Rayanne B Burl, Maik Hüttemann, Roger Pique-Regi, Douglas M Ruden
Traumatic brain injury (TBI) can cause persistent pathological alteration of neurons. This may lead to cognitive dysfunction, depression and increased susceptibility to life threatening diseases, such as epilepsy and Alzheimer's disease. To investigate the underlying genetic and molecular basis of TBI, we subjected w1118Drosophila melanogaster to mild closed head trauma and found that mitochondrial activity is reduced in the brains of these flies 24 h after inflicting trauma. To determine the transcriptomic changes after mild TBI, we collected fly heads 24 h after inflicting trauma, and performed RNA-seq analyses...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29187362/ikk2-nf-%C3%AE%C2%BAb-signaling-protects-neurons-after-traumatic-brain-injury
#16
Melanie Mettang, Stephanie Nadine Reichel, Michael Lattke, Annette Palmer, Alireza Abaei, Volker Rasche, Markus Huber-Lang, Bernd Baumann, Thomas Wirth
Traumatic brain injury (TBI) is the leading cause of death in young adults. After the initial injury, a poorly understood secondary phase, including a strong inflammatory response determines the final outcome of TBI. The inhibitor of NF-κB kinase (IKK)/NF-κB signaling system is the key regulator of inflammation and also critically involved in regulation of neuronal survival and synaptic plasticity. We addressed the neuron-specific function of IKK2/NF-κB signaling pathway in TBI using an experimental model of closed-head injury (CHI) in combination with mouse models allowing conditional regulation of IKK/NF-κB signaling in excitatory forebrain neurons...
November 29, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29187031/minocycline-plus-n-acetylcysteine-reduce-behavioral-deficits-and-improve-histology-with-a-clinically-useful-time-window
#17
Michael Sangobowale, Natalia M Grin'kina, Kristen Whitney, Elena Nikulina, Karrah St Laurent-Arriot, Johnson S Ho, Narek Bazyan, Peter Bergold
There are presently no drugs to treat traumatic brain injury (TBI). A major problem in developing therapeutics is that drugs to treat TBI lack sufficient potency when dosed within a clinically relevant time window. Previous studies have shown that minocycline (MINO, 45mg/kg) plus N-acetylcysteine (NAC, 150mg/kg) synergistically improved cognition and memory, modulated inflammation and prevented loss of oligodendrocytes that remyelinated damaged white matter when first dosed 1 hour (h) after controlled cortical impact (CCI) in rats...
November 29, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29182595/identifying-patients-who-will-most-benefit-from-single-photon-emission-computerized-tomography-and-computerized-tomography-after-femoral-neck-fracture
#18
Wenshuai Fan, Liang Zhu, Jifei Chen, Changan Guo, Zuoqin Yan
BACKGROUND Single photon emission computerized tomography and computerized tomography (SPECT/CT) is useful for assessing blood supply within the femoral head after femoral neck fracture, but its use in all femoral neck fracture patients is not feasible. Therefore, the present study aimed to identify the patients for whom SPECT/CT examination will be most beneficial. MATERIAL AND METHODS Sixty-five patients with a unilateral femoral neck fracture who underwent SPECT/CT examination of the hip and were treated via closed reduction and internal fixation with three screws were enrolled between January 2009 and March 2011...
November 28, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29180170/money-well-spent-a-cost-and-utilization-analysis-of-prophylactic-inferior-vena-cava-filter-placement-in-high-risk-trauma-patients
#19
Margo Nicole Carlin, Alireza Daneshpajouh, Joseph Catino, Marko Bukur
BACKGROUND: Inferior vena cava filters (IVCF) for venous thromboembolic prophylaxis in high-risk trauma patients is a controversial practice. Utilization of IVCF prophylaxis was evaluated at a level 1 trauma center. Daily cost of IVCF prophylaxis, time to IVCF, duration between IVCF and chemoprophylaxis, and number of patients needed to treat (NNT) to prevent pulmonary embolism (PE) was calculated. METHODS: A retrospective review of prophylactic IVCF over a 5-year period (2010-2014)...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29179620/a-novel-method-for-quantifying-human-in-situ-whole-brain-deformation-under-rotational-loading-using-sonomicrometry
#20
Ahmed Alshareef, J Sebastian Giudice, Jason Forman, Robert S Salzar, Matthew B Panzer
Traumatic brain injuries are one of the least understood injuries to the body. Finite element (FE) models of the brain have been crucial for understanding concussion and for developing injury mitigation systems; however, the experimental brain deformation data currently used to validate these models are limited. The objective of this study was to develop a methodology for the investigation of in situ three-dimensional brain deformation during pure rotational loading of the head, using sonomicrometry. Sonomicrometry uses ultrasonic pulses to measure the dynamic distances between piezoelectric crystals implanted in any sound-transmitting media...
November 27, 2017: Journal of Neurotrauma
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