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https://www.readbyqxmd.com/read/29771142/the-development-of-a-mouse-model-of-mtbi-induced-post-traumatic-migraine-and-identification-of-the-delta-opioid-receptor-as-a-novel-therapeutic-target
#1
Laura S Moye, Madeline L Novack, Alycia F Tipton, Harish Krishnan, Subhash C Pandey, Amynah Aa Pradhan
Background Post-traumatic headache is the most common and long-lasting impairment observed following mild traumatic brain injury, and frequently has migraine-like characteristics. The mechanisms underlying progression from mild traumatic brain injury to post-traumatic headache are not fully understood. The aim of this study was to develop a mouse model of post-traumatic headache and identify mechanisms and novel targets associated with this disorder. Methods We combined the closed head weight-drop method and the nitroglycerin chronic migraine model...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29769541/modchimera-a-novel-murine-closed-head-model-of-moderate-traumatic-brain-injury
#2
A D Sauerbeck, C Fanizzi, J H Kim, M Gangolli, P V Bayly, C L Wellington, D L Brody, T T Kummer
Traumatic brain injury is a major source of global disability and mortality. Preclinical TBI models are a crucial component of therapeutic investigation. We report a tunable, monitored model of murine non-surgical, diffuse closed-head injury-modCHIMERA-characterized by impact as well as linear and rotational acceleration. modCHIMERA is based on the Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA) platform. We tested this model at 2 energy levels: 1.7 and 2.1 Joules-substantially higher than previously reported for this system...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768967/interleukin-1-receptor-1-deletion-in-focal-and-diffuse-experimental-traumatic-brain-injury-in-mice
#3
Joon Yong Chung, Nicolas Krapp, Limin Wu, Sevda Lule, Lauren McAllister, William Edmiston Iii, Samantha Martin, Emily Levy, Tanya Songtachalert, John Sherwood, Erin Buckley, Bharat Sanders, Saef Izzy, Suzanne Hickman, Shuzhen Guo, Josephine Lok, Joseph El Khoury, Eng Lo, David Kaplan, Michael Whalen
Important differences in the biology of focal and diffuse traumatic brain injury (TBI) subtypes may result in unique pathophysiological responses to shared molecular mechanisms. Interleukin-1 (IL-1) signaling has been tested as a potential therapeutic target in preclinical models of cerebral contusion and diffuse TBI, and in a phase II clinical trial, but no published studies have examined IL-1 signaling in an impact/acceleration closed head injury (CHI) model. We hypothesized that genetic deletion of IL-1 receptor-1 (IL-1R1 KO) would be beneficial in focal (contusion) and CHI in mice...
May 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29758582/-relevance-of-mri-after-closed-reduction-of-traumatic-hip-dislocation-in-children
#4
Christoph Mauritz Strüwind, Christian von Rüden, Andreas Thannheimer, Volker Bühren, Dorien Schneidmueller
BACKGROUND: Traumatic hip dislocation in children and adolescents is a rare entity that typically results from high-energy trauma. After closed joint reduction, further treatment depends on the specific pattern of the lesion as identified using cross sectional imaging. The aim of this retrospective analysis was to evaluate relevant side effects after traumatic hip dislocation in children and adolescents in order to examine the need for focused diagnostics. PATIENTS/MATERIAL AND METHODS: This retrospective analysis covered 8 adolescents under 18 years suffering isolated traumatic hip joint dislocation between 2001 and 2017...
May 14, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29756683/non-operative-management-of-isolated-single-abdominal-stab-wound-is-it-safe
#5
Hong Xiang Lee, Matthew Hauser, Shivangi Jog, Peter Bautz, Christopher Dobbins
BACKGROUND: This is a retrospective review of prospectively collected data on our hospital, a Level 1 trauma centre, where stable patients with single abdominal stab wounds are considered for non-operative (conservative) management if they fulfil the criteria with the aid of computed tomography. The aim is to review our current approach in managing these patients. METHODS: Patients' data were obtained from January 2005 to June 2016. All injuries classed as assault or self-harm by sharp object in Injury Severity Score body region 4 were included...
May 14, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29754317/prediction-of-brain-deformations-and-risk-of-traumatic-brain-injury-due-to-closed-head-impact-quantitative-analysis-of-the-effects-of-boundary-conditions-and-brain-tissue-constitutive-model
#6
Fang Wang, Yong Han, Bingyu Wang, Qian Peng, Xiaoqun Huang, Karol Miller, Adam Wittek
In this study, we investigate the effects of modelling choices for the brain-skull interface (layers of tissues between the brain and skull that determine boundary conditions for the brain) and the constitutive model of brain parenchyma on the brain responses under violent impact as predicted using computational biomechanics model. We used the head/brain model from Total HUman Model for Safety (THUMS)-extensively validated finite element model of the human body that has been applied in numerous injury biomechanics studies...
May 12, 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29746557/optic-tract-injury-after-closed-head-traumatic-brain-injury-in-mice-a-model-of-indirect-traumatic-optic-neuropathy
#7
Nathan K Evanson, Fernanda Guilhaume-Correa, James P Herman, Michael D Goodman
Adult male C57BL/6J mice have previously been reported to have motor and memory deficits after experimental closed head traumatic brain injury (TBI), without associated gross pathologic damage or neuroimaging changes detectable by magnetic resonance imaging or diffusion tensor imaging protocols. The presence of neurologic deficits, however, suggests neural damage or dysfunction in these animals. Accordingly, we undertook a histologic analysis of mice after TBI. Gross pathology and histologic analysis using Nissl stain and NeuN immunohistochemistry demonstrated no obvious tissue damage or neuron loss...
2018: PloS One
https://www.readbyqxmd.com/read/29739276/corpus-callosum-vasculature-predicts-white-matter-microstructure-abnormalities-following-pediatric-mild-traumatic-brain-injury
#8
Kara M Wendel, Jeong Bin Lee, Bethann Affeldt, Mary Hamer, Indira S Harahap-Carrillo, Andrea C Pardo, Andre Obenaus
Emerging data suggest that pediatric traumatic brain injury (TBI) is associated with impaired developmental plasticity and poorer neuropsychological outcomes than adults with similar head injuries. Unlike adult mild TBI (mTBI), the effects of mTBI on white matter (WM) microstructure and vascular supply are not well-understood in the pediatric population. The cerebral vasculature plays an important role providing necessary nutrients and removing waste. To address this critical element, we examined the microstructure of the corpus callosum (CC) following pediatric mTBI using diffusion tensor imaging (DTI), and investigated myelin, oligodendrocytes, and vasculature of WM with immunohistochemistry...
May 9, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29738554/repeated-mild-traumatic-brain-injury-can-cause-acute-neurologic-impairment-without-overt-structural-damage-in-juvenile-rats
#9
Alicia Meconi, Ryan C Wortman, David K Wright, Katie J Neale, Melissa Clarkson, Sandy R Shultz, Brian R Christie
Repeated concussion is becoming increasingly recognized as a serious public health concern around the world. Moreover, there is a greater awareness amongst health professionals of the potential for repeated pediatric concussions to detrimentally alter the structure and function of the developing brain. To better study this issue, we developed an awake closed head injury (ACHI) model that enabled repeated concussions to be performed reliably and reproducibly in juvenile rats. A neurological assessment protocol (NAP) score was generated immediately after each ACHI to help quantify the cumulative effects of repeated injury on level of consciousness, and basic motor and reflexive capacity...
2018: PloS One
https://www.readbyqxmd.com/read/29733307/method-for-high-speed-stretch-injury-of-human-induced-pluripotent-stem-cell-derived-neurons-in-a-96-well-format
#10
Jack K Phillips, Sydney A Sherman, Sevan R Oungoulian, John D Finan
Traumatic brain injury (TBI) is a major clinical challenge with high morbidity and mortality. Despite decades of pre-clinical research, no proven therapies for TBI have been developed. This paper presents a novel method for pre-clinical neurotrauma research intended to complement existing pre-clinical models. It introduces human pathophysiology through the use of human induced pluripotent stem cell-derived neurons (hiPSCNs). It achieves loading pulse duration similar to the loading durations of clinical closed head impact injury...
April 20, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29730900/strategies-for-the-enhancement-of-nutrition-practice-in-a-new-york-state-level-1-trauma-center-a-hospital-s-journey
#11
Lisa Musillo, Laryssa Marie Grguric, Edward Coffield, Frank Aversano, Jeremy Bosworth, Richard Batista
BACKGROUND: Provision of enteral nutrition (EN) support is historically inadequate in the critically ill population. An interdisciplinary approach utilizing various strategies has been shown to improve initiation of timely EN support. The purpose of this study was to examine whether the implementation of a series of interventions led by an interdisciplinary team was associated with changes in the initiation of nutrition support in a level 1 trauma center. METHODS: Patients admitted between 2009 and 2013 with isolated closed head trauma injuries were identified through the hospital's trauma center database...
December 18, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29728835/muscle-tendon-related-abnormalities-detected-by-ultrasonography-are-common-in-symptomatic-hip-dysplasia
#12
Julie Sandell Jacobsen, Lars Bolvig, Per Hölmich, Kristian Thorborg, Stig Storgaard Jakobsen, Kjeld Søballe, Inger Mechlenburg
INTRODUCTION: Hip dysplasia is characterized by reduced acetabular coverage of the femoral head leading to an increased mechanical load on the hip joint and the acting hip muscles. Potentially, the muscles and tendons functioning close to the hip joint may present with overuse-related ultrasonography findings. The primary aim was to report the prevalence of muscle-tendon-related abnormalities detected by ultrasonography in 100 patients with symptomatic hip dysplasia. The secondary aim was to investigate correlations between muscle-tendon-related abnormalities detected by ultrasonography and clinically identified pain related to muscles and tendons...
May 4, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29719849/avulsion-of-ampulla-of-vater-secondary-to-a-blunt-abdominal-injury-treated-with-pancreatoduodenectomy-a-case-report-and-literature-review
#13
Mustafa Ozsoy, Ogun Ersen, Zehra Ozsoy, Sezgin Yilmaz, Yüksel Arıkan
The incidence of complex hepatobiliary injury secondary to blunt abdominal injuries varies between 3.4 and 5%. A 25-year old male patient underwent an urgent operation due to a motorcycle accident. During intraabdominal exploration, Grade 4 laceration was detected at the liver and bleeding was controlled through primary repair. In the postoperative seventh day, he was referred due to 1500 cc bile leakage from the drainage tube. During the operation, an extensive Kocher maneuver was done and the second part of duodenum was observed to be exposed to total avulsion from the head of the pancreas...
April 2018: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/29698292/does-the-watson-jones-or-modified-smith-petersen-approach-provide-superior-exposure-for-femoral-neck-fracture-fixation
#14
Paul M Lichstein, John P Kleimeyer, Michael Githens, John S Vorhies, Michael J Gardner, Michael Bellino, Julius Bishop
BACKGROUND: A well-reduced femoral neck fracture is more likely to heal than a poorly reduced one, and increasing the quality of the surgical exposure makes it easier to achieve anatomic fracture reduction. Two open approaches are in common use for femoral neck fractures, the modified Smith-Petersen and Watson-Jones; however, to our knowledge, the quality of exposure of the femoral neck exposure provided by each approach has not been investigated. QUESTIONS/PURPOSES: (1) What is the respective area of exposed femoral neck afforded by the Watson-Jones and modified Smith-Petersen approaches? (2) Is there a difference in the ability to visualize and/or palpate important anatomic landmarks provided by the Watson-Jones and modified Smith-Petersen approaches? METHODS: Ten fresh-frozen human pelvi underwent both modified Smith-Petersen (utilizing the caudal extent of the standard Smith-Petersen interval distal to the anterosuperior iliac spine and parallel to the palpable interval between the tensor fascia lata and the sartorius) and Watson-Jones approaches...
April 24, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29694192/mechanistic-insights-into-human-brain-impact-dynamics-through-modal-analysis
#15
Kaveh Laksari, Mehmet Kurt, Hessam Babaee, Svein Kleiven, David Camarillo
Although concussion is one of the greatest health challenges today, our physical understanding of the cause of injury is limited. In this Letter, we simulated football head impacts in a finite element model and extracted the most dominant modal behavior of the brain's deformation. We showed that the brain's deformation is most sensitive in low frequency regimes close to 30 Hz, and discovered that for most subconcussive head impacts, the dynamics of brain deformation is dominated by a single global mode. In this Letter, we show the existence of localized modes and multimodal behavior in the brain as a hyperviscoelastic medium...
March 30, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29692479/evaluation-of-near-infrared-spectroscopy-as-screening-tool-for-detecting-intracranial-hematomas-in-patients-with-traumatic-brain-injury
#16
V Trehan, Vikas Maheshwari, S V Kulkarni, Sanjeev Kapoor, Anurakshat Gupta
Background: Traumatic Brain Injury (TBI) is one of the most common surgical emergencies in service hospitals of India. Computed tomography (CT) has been a consistent and reliable technique for detecting intracranial hemorrhages but is limited by its non-availability in most service hospitals. Therefore the need for a cheaper, portable and easily available option required to be explored. The aim of this study was to determine the sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) of Near Infra Red Spectroscopy (NIRS) against the gold standard of NCCT head...
April 2018: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/29665077/gliovascular-changes-precede-white-matter-damage-and-long-term-disorders-in-juvenile-mild-closed-head-injury
#17
Beatriz Rodriguez-Grande, Andre Obenaus, Aleksandra Ichkova, Justine Aussudre, Thomas Bessy, Elodie Barse, Bassem Hiba, Gwénaëlle Catheline, Grégory Barrière, Jerome Badaut
Traumatic brain injury (TBI) is a leading cause of hospital visits in pediatric patients and often leads to long-term disorders even in cases of mild severity. White matter (WM) alterations are commonly observed in patients months or years after the injury assessed by magnetic resonance imaging (MRI), but little is known about WM pathophysiology early after mild pediatric TBI. To evaluate the status of the gliovascular unit in this context, mild TBI was induced in postnatal-day 17 mice using a closed head injury model with two grades of severity (G1, G2)...
April 17, 2018: Glia
https://www.readbyqxmd.com/read/29648983/enhancement-of-brain-d-serine-mediates-recovery-of-cognitive-function-after-tbi
#18
Sigal Liraz-Zaltsman, Barbara Slusher, Dana Atrakchi-Baranes, Kinneret Rosenblatt, Yael Friedman Levi, Efrat Leah Kesner, Alcino J Silva, Anat Biegon, Esther Shohami
Cognitive deficits, especially memory loss, are common and devastating neuropsychiatric sequelae of traumatic brain injury (TBI). The deficits may persist for a long time and may be accompanied by increased risk of developing early onset dementia. Past attempts to reverse the neuropsychological effects of brain injury with glutamate-N-methyl-D-aspartate (NMDA) antagonists failed to show any benefits or worsened the outcome, suggesting activation, rather than blockage, of the NMDA receptor (NMDAR) may be useful in the sub-acute period after TBI and stroke...
March 14, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29625747/brain-tissue-strains-vary-with-head-impact-location-a-possible-explanation-for-increased-concussion-risk-in-struck-versus-striking-football-players
#19
REVIEW
Benjamin S Elkin, Lee F Gabler, Matthew B Panzer, Gunter P Siegmund
BACKGROUND: On-field football helmet impacts over a large range of severities have caused concussions in some players but not in other players. One possible explanation for this variability is the struck player's helmet impact location. METHODS: We examined the effect of impact location on regional brain tissue strain when input energy was held constant. Laboratory impacts were performed at 12 locations distributed over the helmet and the resulting head kinematics were simulated in two finite element models of the brain: the Simulated Injury Monitor and the Global Human Body Model Consortium brain model...
March 29, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29619502/safe-zone-for-the-posterior-interosseous-nerve-with-regard-to-the-lateral-and-posterior-approaches-to-the-proximal-radius
#20
Gloria Maria Hohenberger, Angelika Maria Schwarz, Marco Johannes Maier, Peter Grechenig, Jan Dauwe, Christoph Grechenig, Renate Krassnig, Axel Gänsslen, Andreas Heinrich Weiglein
PURPOSE: The posterior interosseous nerve (PIN) is at risk during the posterior and lateral approaches to the proximal radius. We aimed to define a safe zone for these approaches to avoid injury of the PIN and to evaluate their close and changing relationship to the nerve during forearm rotation. METHODS: The study collective consisted of 50 upper limbs. After performance of the lateral approach, the distance between the tip of the radial head and the PIN's exit point from the supinator (= distance 1) and the shortest interval between the nerve's exit to the radial margin of the ulna (= distance 2) were measured in maximum pronation and supination...
April 4, 2018: Surgical and Radiologic Anatomy: SRA
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