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Closed head injury

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https://www.readbyqxmd.com/read/27907932/posttraumatic-cavernous-segment-internal-carotid-artery-aneurysmal-rupture-presenting-as-tentorial-subdural-hematoma
#1
Syamala Shunmugam, Thas Emmanuel, Shyam Duvuru
Traumatic aneurysm rupture following a closed head injury is rare. The rupture of a cavernous internal carotid artery (ICA) aneurysm following a head injury presenting as a tentorial subdural hematoma has not been reported in the literature. We discuss a 50-year-old woman with a closed head injury with her initial computed tomography scan showing a tentorial subdural hematoma. Further investigations revealed the presence of a ruptured cavernous ICA aneurysm. We also conducted a literature review of posttraumatic ICA aneurysmal rupture...
December 1, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27902676/dural-sinus-cerebral-venous-thrombosis-in-a-pediatric-trauma-patient-a-rare-complication-after-closed-head-injury
#2
Jonathan Wilcher, Michelle Pannell
OBJECTIVE: Closed head injury rarely predisposes patients, particularly children, to the development of dural sinus thrombosis. In addition, most cases of sinus thrombosis are subacute in nature. The following is a case report of a precipitous course of dural sinus thrombosis after closed head injury in a pediatric trauma patient. DESCRIPTION: A 14-year-old African American girl presented to the emergency department as a trauma activation. She was an unrestrained rear-seat passenger involved in a motor vehicle collision during which she was ejected...
December 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27899434/development-of-cgrp-dependent-pain-and-headache-related-behaviours-in-a-rat-model-of-concussion-implications-for-mechanisms-of-post-traumatic-headache
#3
Dara Bree, Dan Levy
BACKGROUND AND OBJECTIVE: Posttraumatic headache (PTH) is one of the most common, debilitating and difficult symptoms to manage after a mild traumatic brain injury, or concussion. However, the mechanisms underlying PTH remain elusive, in part due to the lack of a clinically relevant animal model. Here, we characterized for the first time, headache and pain-related behaviours in a rat model of concussion evoked by a mild closed head injury (mCHI) - the major type of military and civilian related trauma associated with PTH - and tested responses to current and novel headache therapies...
November 29, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27895200/demographics-mechanisms-of-injury-and-concurrent-injuries-associated-with-calcaneus-fractures-a-study-of-14-516-patients-in-the-american-college-of-surgeons-national-trauma-data-bank
#4
Daniel D Bohl, Nathaniel T Ondeck, Andre M Samuel, Pablo J Diaz-Collado, Stephen J Nelson, Bryce A Basques, Michael P Leslie, Jonathan N Grauer
: Background This study uses the American College of Surgeons National Trauma Data Bank (NTDB) to update the field on the demographics, injury mechanisms, and concurrent injuries among a national sample of patients admitted to the hospital department with calcaneus fractures. Methods Patients with calcaneus fractures in the NTDB during 2011-2012 were identified and assessed. Results A total of 14 516 patients with calcaneus fractures were included. The most common comorbidity was hypertension (18%), and more than 90% of fractures occurred via traffic accident (49%) or fall (43%)...
November 28, 2016: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/27884214/neuronal-and-glial-changes-in-the-brain-resulting-from-explosive-blast-in-an-experimental-model
#5
James A Goodrich, Jung H Kim, Robert Situ, Wesley Taylor, Ted Westmoreland, Fu Du, Steven Parks, Geoffrey Ling, Jung Y Hwang, Amedeo Rapuano, Faris A Bandak, Nihal C de Lanerolle
Mild traumatic brain injury (mTBI) is the signature injury in warfighters exposed to explosive blasts. The pathology underlying mTBI is poorly understood, as this condition is rarely fatal and thus postmortem brains are difficult to obtain for neuropathological studies. Here we report on studies of an experimental model with a gyrencephalic brain that is exposed to single and multiple explosive blast pressure waves. To determine injuries to the brain resulting from the primary blast, experimental conditions were controlled to eliminate any secondary or tertiary injury from blasts...
November 24, 2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27854112/large-traumatic-basal-ganglia-hematoma-surgical-treatment-versus-conservative-management
#6
Humain Baharvahdat, Babak Ganjifar, Hamid Etemadrezaie, Ali Gorji
BACKGROUND: Traumatic basal ganglia hematomas (TBGHs) are uncommon events in patients with closed head injuries. The overall prognosis is poor, particularly when large hematoma exists. This study was designed to compare surgical evacuation through transsylvian-transinsular approach with conservative management in large TBGHs. METHODS: Thirty-two patients, admitted between July 2002 and July 2013, with closed head injury and TBGH more than 25 ml were included in this study...
November 17, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27850896/1260-utilization-of-head-ct-in-adults-visiting-the-ed-with-closed-head-injury-concussion-need-for-less
#7
Sankeerth Rampa, Romesh Nalliah, Min Kyeong Lee, Veerasathpurush Allareddy, Veerajalandhar Allareddy
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850366/728-head-ct-utilization-in-children-visiting-the-ed-with-closed-head-injury
#8
Onyinyechi Ukwuoma, Veerajalandhar Allareddy, Veerasathpurush Allareddy, Sankeerth Rampa, Jerri Rose, Alexandre Rotta
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27845037/novel-glp-1r-gipr-co-agonist-twincretin-is-neuroprotective-in-cell-and-rodent-models-of-mild-traumatic-brain-injury
#9
Ian A Tamargo, Miaad Bader, Yazhou Li, Seong-Jin Yu, Yun Wang, Konrad Talbot, Richard D DiMarchi, Chaim G Pick, Nigel H Greig
Several single incretin receptor agonists that are approved for the treatment of type 2 diabetes mellitus (T2DM) have been shown to be neuroprotective in cell and animal models of neurodegeneration. Recently, a synthetic dual incretin receptor agonist, nicknamed "twincretin," was shown to improve upon the metabolic benefits of single receptor agonists in mouse and monkey models of T2DM. In the current study, the neuroprotective effects of twincretin are probed in cell and mouse models of mild traumatic brain injury (mTBI), a prevalent cause of neurodegeneration in toddlers, teenagers and the elderly...
November 11, 2016: Experimental Neurology
https://www.readbyqxmd.com/read/27842519/administration-of-electroconvulsive-therapy-for-depression-associated-with-deep-brain-stimulation-in-a-patient-with-post-traumatic-parkinson-s-disease-a-case-study
#10
Miles G Cunningham, Golnaz Yadollahikhales, Gordana Vitaliano, Craig van Horne
BACKGROUND: Deep brain stimulation (DBS) has been shown to be effective for parkinsonian symptoms poorly responsive to medications. DBS is typically well-tolerated, as are the maintenance battery changes. Here we describe an adverse event during a battery replacement procedure that caused rapid onset of severe depression. CASE PRESENTATION: The patient is a 58-year-old woman who was in a serious motor vehicle accident and sustained a concussion with loss of consciousness...
November 15, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27834542/inflammatory-changes-in-optic-nerve-after-closed-head-repeated-traumatic-brain-injury-preliminary-study
#11
Radouil Tzekov, Josie Phifer, April Myers, Benoit Mouzon, Fiona Crawford
BACKGROUND: Closed-head, repeated, mild traumatic brain injury (r-mTBI) leads to inflammatory and degenerative changes in the optic nerve of young wild type mice. This work has investigated whether similar changes may be present when the same model is applied to htau mice, a transgenic mouse in which the non-mutated human tau gene is expressed on a null murine tau background. METHODS: This study investigated neuropathological changes in the optic nerve in both young (15 weeks) and old (65-70 weeks) htau mice at 24 hours after r-mTBI or anaesthesia only (r-sham)...
2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27833713/extensive-cervicomediastinal-emphysema-from-mastoid-injury
#12
Yasmina Ahmed, Matthew Ng
Traumatic cervicomediastinal emphysema resulting from isolated head trauma is a rare occurrence. Herein, we describe a patient who sustained a closed mastoid injury after being struck with a batted baseball, resulting in acute extensive cervicomediastinal emphysema. Upon further assessment, the patient's aerodigestive tract was determined to have remained intact and unaffected by the injury. The source of soft-tissue air originated from the fractured mastoid. This case demonstrates the protective properties of a well-pneumatized mastoid...
November 2016: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/27818218/role-of-microglia-in-a-mouse-model-of-paediatric-traumatic-brain-injury
#13
Vibol Chhor, Raffaella Moretti, Tifenn Le Charpentier, Stephanie Sigaut, Sophie Lebon, Leslie Schwendimann, Marie-Virginie Oré, Chiara Zuiani, Valentina Milan, Julien Josserand, Regina Vontell, Julien Pansiot, Vincent Degos, Chrysanthy Ikonomidou, Luigi Titomanlio, Henrik Hagberg, Pierre Gressens, Bobbi Fleiss
The cognitive and behavioural deficits caused by traumatic brain injury (TBI) to the immature brain are more severe and persistent than TBI in the mature brain. Understanding this developmental sensitivity is critical as children under four years of age sustain TBI more frequently than any other age group. Microglia (MG), resident immune cells of the brain that mediate neuroinflammation, are activated following TBI in the immature brain. However, the type and temporal profile of this activation and the consequences of altering it are still largely unknown...
November 4, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27815953/early-complications-associated-with-the-thompson-approach-to-the-proximal-radius
#14
Donato J Perretta, Kenneth M Brock, Nirmal C Tejwani
PURPOSE: The purpose of this study was to investigate the early complications associated with the dorsal approach to the proximal radius. This approach, also called the Thompson approach, is used relatively infrequently for the treatment of forearm fractures. It is primarily reserved for proximal one-third radius fractures where a volar plate may not be placed sufficiently proximal for adequate fixation. METHODS: A retrospective chart review was performed on forearm fractures performed at our institution...
November 2016: Bulletin of the Hospital for Joint Diseases
https://www.readbyqxmd.com/read/27799012/selective-brain-hypothermia-mitigates-brain-damage-and-improves-neurological-outcome-after-posttraumatic-decompressive-craniectomy-in-mice
#15
Jacek Szczygielski, Andreas Müller, Angelika E Mautes, Christoph Sippl, Cosmin Glameanu, Karsten Schwerdtfeger, Wolf-Ingo Steudel, Joachim Oertel
Hypothermia and decompressive craniectomy have been considered as treatment for traumatic brain injury. The present study investigates whether selective brain hypothermia added to craniectomy could improve neurological outcome after brain trauma. Male CD-1 mice were assigned into the following groups: sham, decompressive craniectomy (DC), closed head injury (CHI), CHI followed by craniectomy (CHI+DC), CHI+DC followed by focal hypothermia (CHI+DC+H). At 24h posttrauma animals were subjected to Neurological Severity Score test (NSS) and Beam Balance Score test (BBS)...
October 31, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27794484/prospective-tracking-and-analysis-of-traumatic-brain-injury-in-veterans-and-military-personnel
#16
Nytzia E Licona, Joyce S Chung, John Poole, Rose M Salerno, Nancy Laurenson, Odette A Harris
OBJECTIVE: Describe the ongoing Clinical Tracking Form (CTF) study of the Defense and Veterans Brain Injury Center (DVBIC). DESIGN: Prospective longitudinal study. Data at baseline and post-injury are collected on participants through interview and questionnaire, review of medical records and periodic follow-ups throughout their lifetime. SETTING: A regional DVBIC site located at a Veterans Affairs Medical Center. PARTICIPANTS: 211 participants (age range, 18-75y) were enrolled between 2005 and 2012 at a regional DVBIC site...
October 26, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27762651/a-clinically-relevant-closed-head-model-of-single-and-repeat-concussive-injury-in-the-adult-rat-using-a-controlled-cortical-impact-device
#17
Naseem Jamnia, Janice H Urban, Grace Beth Stuzmann, Sarah Chiren, Emily Reisenbigler, Robert Marr, Daniel A Peterson, Dorothy A Kozlowski
Repeat concussions (RC) can result in significant long-term neurological consequences and increased risk for neurodegenerative disease compared to single concussion (SC). Mechanisms underlying this difference are poorly understood and best elucidated using an animal model. To the best of our knowledge, there is no closed-head model in the adult rat using a commercially available device. We developed a novel and clinically relevant closed-head injury (CHI) model of both single and multiple concussions in the adult rat using a controlled cortical impact (CCI) device...
October 20, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27753717/pediatric-referrals-to-an-emergency-department-from-urgent-care-centers
#18
Robert P Olympia, Robert Wilkinson, Jennifer Dunnick, Brendan J Dougherty, Debra Zauner
OBJECTIVE: The aims of this study were to describe pediatric emergency department (ED) referrals from urgent care centers and to determine the percentage of referrals considered essential and serious. METHODS: A prospective study was conducted between April 2013 and April 2015 on patients younger than 21 years referred directly to an ED in central Pennsylvania from surrounding urgent care centers. Referrals were considered essential or serious based on investigations/procedures performed or medications/consultations received in the ED...
October 8, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27744073/does-decorin-protect-neuronal-tissue-via-its-antioxidant-and-antiinflammatory-activity-from-traumatic-brain-injury-an-experimental-study
#19
Rafet Özay, Erhan Türkoğlu, Bora Gürer, Habibullah Dolgun, Oya Evirgen, Berrin İmge Ergüder, Nazlı Hayırlı, Levent Gürses, Zeki Şekerci, Erdal Reşit Yılmaz
BACKGROUND: The development of secondary brain injury via oxidative stress after traumatic brain injury (TBI) is well known. Decorin inactivates Transforming growth factor-β1 (TGF-β1), complement system (CS) and Tumor necrosis factor-α (TNF-α) which are related the oxidative stress and apoptosis. Consequently, the aim of the present study was to evaluate the role of Decorin (DC) on TBI. METHODS: A total of 24 male rats were used and divided into four groups as follows; control, trauma, DC, and methylprednisolone (MP)...
October 12, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27742370/traumatic-pneumorrachis-after-isolated-closed-head-injuries-an-up-to-date-review
#20
Georgios F Hadjigeorgiou, Ranjodh Singh, Panagiotis Stefanopoulos, Adamantios Petsanas, Fivos G Hadjigeorgiou, Kostas Fountas
Pneumorrachis (PR) is characterized by the presence of air within the spinal canal. It can be classified descriptively into internal or intradural and external or epidural. The causes of PR can be divided as iatrogenic, nontraumatic and traumatic. In the present study, a comprehensive literature search was conducted to identify all previous cases of PR after an isolate head injury. Two additional cases were also reported. We concluded, that PR after isolated head injuries is a rare but likely an underdiagnosed entity...
October 11, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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