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https://www.readbyqxmd.com/read/29471349/intestinal-colonization-traits-of-pandemic-multidrug-resistant-escherichia-coli-st131
#1
Sohinee Sarkar, Melanie L Hutton, Dimitrios Vagenas, Rinaldo Ruter, Stephanie Schüller, Dena Lyras, Mark A Schembri, Makrina Totsika
Background: Epidemiological studies point to the gut as a key reservoir of multidrug resistant Escherichia coli multilocus sequence type 131 (ST131), a globally dominant pathogenic clone causing urinary tract and bloodstream infections. Here we report a detailed investigation of its intestinal lifestyle. Methods: Clinical ST131 isolates and type 1 fimbriae null mutants were assessed for colonization of human intestinal epithelia and in mouse intestinal colonization models...
February 16, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29471284/adverse-metabolic-effects-in-fish-exposed-to-contaminants-of-emerging-concern-in-the-field-and-laboratory
#2
James P Meador, Andrew Yeh, Evan P Gallagher
Several metabolic parameters were assessed in juvenile Chinook salmon (Oncorhynchus tshawytscha) and staghorn sculpin (Leptocottus armatus) residing in two estuaries receiving wastewater treatment effluent and one reference estuary. We also conducted a laboratory study with fish dosed for 32 days with 16 of the most common contaminants of emerging concern (CECs) detected in feral fish. Several blood chemistry parameters and other indicators of health were measured in fish from the field and laboratory study that were used to assess potential metabolic disruption...
February 19, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29471007/risk-assessment-of-benzene-in-food-samples-of-iran-s-market
#3
Ali Heshmati, Sabah Ghadimi, Amin Mousavi Khaneghah, Francisco J Barba, Jose M Lorenzo, Fatemeh Nazemi, Yadolah Fakhri
The concentration of benzene in ninety-eight collected food and drink samples (carbonated beverage, fruit juice, pickle, lime juice, mayonnaise and salad dressing, 16 samples from each) from Iran local markets were investigated using gas chromatography equipped with flame ionization detector (GC-FID). Moreover, the correlation of benzene concentration with sodium benzoate and ascorbic acid concentrations was assessed. Benzene concentration in carbonated beverages, fruit juices, pickle, lime juices, mayonnaise and salad dressing were 3...
February 19, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29470997/predictors-of-favorable-outcome-after-mechanical-thrombectomy-for-anterior-circulation-acute-ischemic-stroke-in-octogenarians
#4
Matthias Barral, Louis Lassalle, Cyril Dargazanli, Mikael Mazighi, Hocine Redjem, Raphael Blanc, Georges Rodesch, Bertrand Lapergue, Michel Piotin
INTRODUCTION: Mechanical thrombectomy for anterior circulation large vessel occlusion (LVO) improves functional outcome at three months. This therapeutic approach is the new gold standard, with a benefit being also observed in elderly patients. However, data are limited in this heterogeneous and fragile population. The objectives of this study were, first, to describe outcome after mechanical thrombectomy in a representative group of patients over 80. Second, to evaluate factors associated with a favorable functional outcome after thrombectomy for anterior circulation LVO in elderly patients (aged≥ 80 years)...
February 19, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29470861/mini-cog-for-the-diagnosis-of-alzheimer-s-disease-dementia-and-other-dementias-within-a-primary-care-setting
#5
REVIEW
Dallas P Seitz, Calvin Ch Chan, Hailey T Newton, Sudeep S Gill, Nathan Herrmann, Nadja Smailagic, Vasilis Nikolaou, Bruce A Fage
BACKGROUND: Alzheimer's disease and other forms of dementia are becoming increasingly common with the aging of most populations. The majority of individuals with dementia will first present for care and assessment in primary care settings. There is a need for brief dementia screening instruments that can accurately diagnose dementia in primary care settings. The Mini-Cog is a brief, cognitive screening test that is frequently used to evaluate cognition in older adults in various settings...
February 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29469024/association-between-body-composition-and-pulmonary-function-in-children-and-young-people-with-cystic-fibrosis
#6
Patrizia Calella, Giuliana Valerio, Matt Thomas, Helen McCabe, Jake Taylor, Malcolm Brodlie, Mario Siervo
OBJECTIVES: Body mass index (BMI) has significant limitations when assessing nutritional status in pediatric patients with cystic fibrosis (CF). We evaluated whether measurements of lean body mass (LBM) and fat mass (FM) are more sensitive nutritional parameters by testing their association with pulmonary function in adolescent patients with CF. METHODS: Sixty-nine male and female adolescents with CF were studied (age: 14.5 ± 2.3, BMI: 19.5 ± 2.3 kg/m2 )...
December 5, 2017: Nutrition
https://www.readbyqxmd.com/read/29468867/a-simple-and-sensitive-method-for-determination-of-protein-kinase-activity-based-on-surface-charge-change-of-peptide-modified-gold-nanoparticles-as-substrates
#7
Fang Yi, Xiangyi Huang, Jicun Ren
Protein tyrosine kinases play a pivotal role in intracellular signal transduction pathways and oncogenic transformation. It is necessary to develop a simple, cost-effective and sensitive kinase assay for study of protein kinases and discovery of kinase-target drugs. In this paper, we present a simple and sensitive method for homogeneous detection of protein kinase activity and screening of inhibitor by measuring surface charge change on the peptide-modified gold nanoparticles (GNPs) as kinase substrates. In this assay, Abl (Abelson murine leukemia viral oncogene) kinase was used as a model...
February 22, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29468738/combined-effects-of-environmental-factors-on-human-perception-and-objective-performance-a-review-of-experimental-laboratory-works
#8
REVIEW
S Torresin, G Pernigotto, F Cappelletti, A Gasparella
The present paper reports the outcomes of a literature survey aimed at exploring how different environmental factors - i.e. acoustic, thermal, visual and air quality stimuli - interact in affecting building occupants' perception and performance. Recent laboratory studies have been collected and their methodological approaches reviewed in terms of experimental design, adopted exposures conditions, perception and performance assessment methods. Results have been summarized and compared to identify interaction patterns between environmental factors and possible practical implications for improving the design of both experimental studies and the built environment...
February 22, 2018: Indoor Air
https://www.readbyqxmd.com/read/29468638/accuracy-of-point-of-care-hba1c-testing-in-pregnant-women
#9
Katherine Culliney, Lesley M E McCowan, Karaponi Okesene-Gafa, Rinki Murphy, Janet Rowan, Rennae S Taylor, Christopher J D Mckinlay
BACKGROUND: In New Zealand, it is recommended that all pregnant women have a haemoglobin A1c (HbA1c) test performed with their booking antenatal bloods to identify previously unrecognised diabetes. However, screening rates in some groups are low. Use of a point-of-care device may improve compliance with screening. AIM: To assess the accuracy of the COBAS b101 point-of-care system referenced against a laboratory method, for measurement of HbA1c levels in pregnant women...
February 22, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29468601/patient-and-clinician-perspectives-on-shared-decision-making-in-early-adopting-lung-cancer-screening-programs-a-qualitative-study
#10
Renda Soylemez Wiener, Elisa Koppelman, Rendelle Bolton, Karen E Lasser, Belinda Borrelli, David H Au, Christopher G Slatore, Jack A Clark, Hasmeena Kathuria
BACKGROUND: Guidelines recommend, and Medicare requires, shared decision-making between patients and clinicians before referring individuals at high risk of lung cancer for chest CT screening. However, little is known about the extent to which shared decision-making about lung cancer screening is achieved in real-world settings. OBJECTIVE: To characterize patient and clinician impressions of early experiences with communication and decision-making about lung cancer screening and perceived barriers to achieving shared decision-making...
February 21, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29468474/estimation-of-forest-aboveground-biomass-and-uncertainties-by-integration-of-field-measurements-airborne-lidar-and-sar-and-optical-satellite-data-in-mexico
#11
Mikhail Urbazaev, Christian Thiel, Felix Cremer, Ralph Dubayah, Mirco Migliavacca, Markus Reichstein, Christiane Schmullius
BACKGROUND: Information on the spatial distribution of aboveground biomass (AGB) over large areas is needed for understanding and managing processes involved in the carbon cycle and supporting international policies for climate change mitigation and adaption. Furthermore, these products provide important baseline data for the development of sustainable management strategies to local stakeholders. The use of remote sensing data can provide spatially explicit information of AGB from local to global scales...
February 21, 2018: Carbon Balance and Management
https://www.readbyqxmd.com/read/29467621/immunosignals-of-oligodendrocyte-markers-and-myelin-associated-proteins-are-critically-affected-after-experimental-stroke-in-wild-type-and-alzheimer-modeling-mice-of-different-ages
#12
Dominik Michalski, Anna L Keck, Jens Grosche, Henrik Martens, Wolfgang Härtig
Because stroke therapies are still limited and patients are often concerned by long-term sequelae with significant impairment of daily living, elaborated neuroprotective strategies are needed. During the last decades, research substantially improved the knowledge on cellular pathologies responsible for stroke-related tissue damage. In this context, the neurovascular unit (NVU) concept has been established, summarizing the affections of neurons, associated astrocytes and the vasculature. Although oligodendrocytes were already identified to play a major role in other brain pathologies, their role during stroke evolution and long-lasting tissue damage is poorly understood...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29467037/strategies-for-successful-trauma-registry-implementation-in-low-and-middle-income-countries-protocol-for-a-systematic-review
#13
Tiffany Paradis, Etienne St-Louis, Tara Landry, Dan Poenaru
BACKGROUND: The benefits of trauma registries have been well described. The crucial data they provide may guide injury prevention strategies, inform resource allocation, and support advocacy and policy. This has been shown to reduce trauma-related mortality in various settings. Trauma remains a leading cause of mortality in low- and middle-income countries (LMICs). However, the implementation of trauma registries in LMICs can be challenging due to lack of funding, specialized personnel, and infrastructure...
February 21, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29466596/acute-respiratory-distress-syndrome-advances-in-diagnosis-and-treatment
#14
Eddy Fan, Daniel Brodie, Arthur S Slutsky
Importance: Acute respiratory distress syndrome (ARDS) is a life-threatening form of respiratory failure that affects approximately 200 000 patients each year in the United States, resulting in nearly 75 000 deaths annually. Globally, ARDS accounts for 10% of intensive care unit admissions, representing more than 3 million patients with ARDS annually. Objective: To review advances in diagnosis and treatment of ARDS over the last 5 years. Evidence Review: We searched MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews from 2012 to 2017 focusing on randomized clinical trials, meta-analyses, systematic reviews, and clinical practice guidelines...
February 20, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29465750/identification-of-pyrg-used-as-an-endogenous-reference-gene-in-qualitative-and-real-time-quantitative-pcr-detection-of-pleurotus-ostreatus
#15
Shi Zheng, Luying Shan, Yongliang Zhuang, Ying Shang
As a well-known edible fungus rich in nutrients, Pleurotus ostreatus has been used as an alternative to expensive wild edible fungi. Specifically, the fact that using P. ostreatus instead of other expensive wild edible fungi has damaged the rights and interests of consumers. Among the existing methods for detection of food adulteration, the amplification of endogenous reference gene is the most accurate method. However, an ideal endogenous reference gene for P. ostreatus has yet to be developed. In this study, a DNA extraction method for P...
February 21, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29465747/antibiotics-for-treating-gonorrhoea-in-pregnancy
#16
REVIEW
Gabriella Comunián-Carrasco, Guiomar E Peña-Martí, Arturo J Martí-Carvajal
BACKGROUND: Gonorrhoea is a sexually transmitted infection that is caused by Neisseria gonorrhoeae, and is a major public health challenge today. N gonorrhoeae can be transmitted from the mother's genital tract to the newborn during birth, and can cause gonococcal ophthalmia neonatorum as well as systemic neonatal infections. It can also cause endometritis and pelvic sepsis in the mother. This review updates and replaces an earlier Cochrane Review on antibiotics for treating this infectious condition...
February 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29465147/research-on-mesophilic-aerobic-microorganisms-and-enterobacteriaceae-in-cultivated-and-commercialized-agaricus-bisporus
#17
M Donzellini, C Lorini, S Palazzoni, M Becciolini, A Cibecchini, M Talini, G Bonaccorsi
BACKGROUND: Production and consumption of fresh mushrooms reached high levels in recent years but only a few data regarding microbiological quality of these products are available, although their potential microbial load is expected to be high. EU and Italian legislation have not set a limit on microbial counts in these products and label information is often unclear. This study investigates the microbial quality of samples of fresh cultivated mushrooms sold in Tuscany so that both food business operators and legislators can obtain data about potential microbial risk for consumers and debate about the opportunity of realizing an update on fresh mushrooms labels that should include information to protect consumers' health...
March 2018: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29464690/bis-monitoring-versus-clinical-assessment-for-sedation-in-mechanically-ventilated-adults-in-the-intensive-care-unit-and-its-impact-on-clinical-outcomes-and-resource-utilization
#18
REVIEW
Rajesh M Shetty, Antonio Bellini, Dhuleep S Wijayatilake, Mark A Hamilton, Rajesh Jain, Sunil Karanth, ArunKumar Namachivayam
BACKGROUND: Patients admitted to intensive care and on mechanical ventilation, are administered sedative and analgesic drugs to improve both their comfort and interaction with the ventilator. Optimizing sedation practice may reduce mortality, improve patient comfort and reduce cost. Current practice is to use scales or scores to assess depth of sedation based on clinical criteria such as consciousness, understanding and response to commands. However these are perceived as subjective assessment tools...
February 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29464383/concentric-malar-lift-in-the-management-of-lower-eyelid-rejuvenation-or-retraction-a-clinical-retrospective-study-on-342-cases-13-years-after-the-first-publication
#19
Claude Le Louarn
BACKGROUND: Lower eyelid rejuvenation can, unfortunately, induce scleral show even if the lower eyelid procedure is limited. This study was designed to assess the effectiveness and reliability of the concentric malar lift technique in two scenarios: the first, in rejuvenation of the mid-face and, the second, in reconstructive surgery for correction of congenital or acquired eyelids malposition. METHODS: The concentric malar lift technique was first published by Le Louarn (Aesthet Plast Surg 28(6):359-372, 2004)...
February 20, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29464179/leukocyte-cell-derived-chemotaxin-2-associated-renal-amyloidosis-a-case-report
#20
Gagandeep Kaur, Babitha Bijin, Kamron Saleem, Benjamin Sarsah, Bijin Thajudeen
Amyloidosis is a disorder characterized by the deposition of abnormal protein fibrils in tissues. Leukocyte cell-derived chemotaxin 2-associated amyloidosis is a recently recognized entity and is characterized by a distinctive clinicopathologic type of amyloid deposition manifested in adults by varying degrees of impaired kidney function and proteinuria. There are only a limited number of cases reported in the literature. We present a 64-year-old Hispanic female with a history of hypertension who was referred for chronic kidney disease management...
May 2017: Case Reports in Nephrology and Dialysis
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