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Heverton Leandro Carneiro Dutra, Silvia Lomeu Rodrigues, Simone Brutman Mansur, Sofia Pimenta de Oliveira, Eric Pearce Caragata, Luciano Andrade Moreira
The endosymbiotic bacterium Wolbachia spreads rapidly through populations of Aedes aegypti mosquitoes, and strongly inhibits infection with key human pathogens including the dengue and Zika viruses. Mosquito control programs aimed at limiting transmission of these viruses are ongoing in multiple countries, yet there is a dearth of mass rearing infrastructure specific to Wolbachia-infected mosquitoes. One example is the lack of a blood meal substitute, which accounts for the Wolbachia-specific physiological changes in infected mosquitoes, that allows the bacterium to spread, and block viral infections...
November 16, 2017: Scientific Reports
F J Tavares Sánchez-Monge, I Aguado Maestro, A Bañuelos Díaz, M Á Martín Ferrero, M F García Alonso
OBJECTIVE: To evaluate the efficacy of topical tranexamic acid topical in cementless total hip arthroplasty from the point of view of bleeding, transfusion requirements and length of stay, and describe the complications of use compared to a control group. MATERIAL AND METHODS: A prospective, randomised, double-blinded and controlled study including all patients undergoing cementless total hip arthroplasty in our centre between June 2014 and July 2015. Blood loss was estimated using the formula described by Nadler and Good...
November 8, 2017: Revista Española de Cirugía Ortopédica y Traumatología
Laurens Verhaeghe, Luk Bruyneel, Elisabeth Stragier, Marc Ferrante, Daan Dierickx, Hans Prenen
Background: Knowledge of the role of intravenous iron without the use of additional erythropoietic stimulating agents in anemic cancer patients is limited. This study evaluated the effect of ferric carboxymaltose (FCM) in a group of digestive oncology (DIO) patients and aimed to differentiate therapy response according to different types of iron deficiency (ID) anemia. Methods: In this retrospective study, we identified DIO patients who were receiving FCM and had eligible baseline and follow-up hemoglobin (Hb) levels that did not require red blood cell transfusion...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Paola S Oviedo, German E Pieslinger, Alejandro Cadranel, Luis M Baraldo
In this work, we report the evolution of the properties of the inter-valence charge transfer (IVCT) transition in a family of cyanide-bridged ruthenium polypyridines of general formula [Ru(II)(tpy)(bpy)(μ-CN)Ru(III)(bpy)2(L)](3/4+) (tpy = 2,2',6',2''-terpyridine; bpy = 2,2'-bipyridine; L = Cl(-), NCS(-), 4-dimethylaminopyridine or acetonitrile). In these complexes, the redox potential difference between both ruthenium centers (ΔE) is systematically modified. A decrease in ΔE causes a red shift of the energy and an intensity enhancement of the observed IVCT transitions...
November 2, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
J Luke Pryor, Riana R Pryor, Andrew Grundstein, Douglas J Casa
CONTEXT:   The National Athletic Trainers' Association recommends using onsite wet-bulb globe temperature (WBGT) measurement to determine whether to modify or cancel physical activity. However, not all practitioners do so and instead they may rely on the National Weather Service (NWS) to monitor weather conditions. OBJECTIVE:   To compare regional NWS WBGT estimates with local athletic-surface readings and compare WBGT measurements among various local athletic surfaces...
November 2, 2017: Journal of Athletic Training
B J Shappee, J D Simon, M R Drout, A L Piro, N Morrell, J L Prieto, D Kasen, T W-S Holoien, J A Kollmeier, D D Kelson, D A Coulter, R J Foley, C D Kilpatrick, M R Siebert, B F Madore, A Murguia-Berthier, Y-C Pan, J X Prochaska, E Ramirez-Ruiz, A Rest, C Adams, K Alatalo, E Bañados, J Baughman, R A Bernstein, T Bitsakis, K Boutsia, J R Bravo, F Di Mille, C R Higgs, A P Ji, G Maravelias, J L Marshall, V M Placco, G Prieto, Z Wan
On 17 August 2017, Swope Supernova Survey 2017a (SSS17a) was discovered as the optical counterpart of the binary neutron star gravitational wave event GW170817. We report time-series spectroscopy of SSS17a from 11.75 hours until 8.5 days after merger. Over the first hour of observations the ejecta rapidly expanded and cooled. Applying blackbody fits to the spectra, we measure the photosphere cooling from [Formula: see text] K to [Formula: see text] K, and determine a photospheric velocity of roughly 30% of the speed of light...
October 16, 2017: Science
A Blasi, A Sabate, J Beltran, M Costa, R Reyes, F Torres
BACKGROUND: Thromboelastometry may reduce red blood cell (RBC) transfusion in liver transplantation (LT). Fibrinogen concentration is a primary determinant of FIBTEM maximum clot firmness (MCF), but several factors could affect the correlation between FIBTEM MCF and fibrinogen values. We aimed to investigate (1) the concordance between fibrinogen level and FIBTEM MCF and (2) the association of fibrinogen level and FIBTEM MCF with RBC transfusion during LT. METHODS: A post hoc analysis of data from a randomized, multicentre, double-blind, saline/fibrinogen trial was used (NCT01539057)...
October 8, 2017: Vox Sanguinis
Paula Trujillo, Paul E Summers, Alex K Smith, Seth A Smith, Luca T Mainardi, Sergio Cerutti, Daniel O Claassen, Antonella Costa
PURPOSE: We sought to measure quantitative magnetization transfer (qMT) properties of the substantia nigra pars compacta (SNc) in patients with Parkinson's disease (PD) and healthy controls (HCs) using a full qMT analysis and determine whether a rapid single-point measurement yields equivalent results for pool size ratio (PSR). METHODS: Sixteen different MT-prepared MRI scans were obtained at 3 T from 16 PD patients and eight HCs, along with B1, B0, and relaxation time maps...
December 2017: Neuroradiology
Louise F Wilson, Annika Antonsson, Adele C Green, Susan J Jordan, Bradley J Kendall, Christina M Nagle, Rachel E Neale, Catherine M Olsen, Penelope M Webb, David C Whiteman
Cancer is a leading cause of disease burden in Australia, particularly fatal burden, accounting for an estimated thirty percent of deaths. Many cancers develop because of exposure to lifestyle and environmental factors that are potentially modifiable. We aimed to quantify the proportions and numbers of cancer deaths and cases in Australia in 2013 attributable to 20 modifiable factors in eight broad groupings that are established causes of cancer, namely: tobacco smoke (smoking and second-hand), dietary factors (low intake of fruit, non-starchy vegetables and dietary fibre; and high intake of red and processed meat), overweight/obesity, alcohol, physical inactivity, solar ultraviolet radiation, infections (seven agents), and reproductive factors (lack of breastfeeding, menopausal hormone therapy use, combined oral contraceptive use)...
October 6, 2017: International Journal of Cancer. Journal International du Cancer
Nesrine S El-Mezayen, Wessam F El-Hadidy, Wessam M El-Refaie, Th I Shalaby, Mahmoud M Khattab, Aiman S El-Khatib
Liver fibrosis is a global health problem without approved treatment. Imatinib inhibits two key profibrotic pathways; platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-β) and thus can be used to treat liver fibrosis. However, conventional imatinib therapy is hampered by low concentration at target tissue and increased toxicity to other tissues especially heart, lung and liver. Since hepatic stellate cells (HSCs) are the main contributors to liver fibrosis pathogenesis and sole hepatic vitamin A (VA) storage cells, they can be actively targeted by coupling liposomes to VA...
September 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
Fasina Makkar, Kajal Chakraborty
Phytochemical investigation of the thalli of ethyl acetate-methanol extract of the red seaweed Gracilaria opuntia led to isolation of a substituted 2H-chromen derivative of unusual structure possessing highly oxygenated carbon skeleton, characterised as 2-acetoxy-2-(5-acetoxy-4-methyl-2-oxotetrahydro-2H-pyran-4-yl)ethyl 4-(3-methoxy-2-(methoxymethyl)-7-methyl-3,4,4a,7,8,8a-hexahydro-2H-chromen-4-yloxy)-5-methylheptanoate, which have not been reported in nature. The chemical structure was resolved by detailed spectroscopic analysis...
September 25, 2017: Natural Product Research
Tammy L Jones-Lepp, Vince Taguchi, Wayne Sovocool, Don Betowski, Patrick DeArmond, Brian Schumacher, Witold Winnik, Rick McMillin, Chris Armstrong
Provisional molecular weights and chemical formulas were assigned to 4 significant previously unidentified contaminants present during active fish kills in the Red River region of Oklahoma. The provisional identifications of these contaminants were determined using high-resolution liquid chromatography-time-of-flight mass spectrometry (LC-TOFMS), LC-Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICRMS), and LC-ion trap mass spectrometry (LC-ITMS). Environmental water samples were extracted using a solid-phase extraction (SPE) method, and sediment samples were extracted using a modified sonication liquid extraction method...
September 21, 2017: Environmental Toxicology and Chemistry
Mathieu Gayda, Vincent Gremeaux, Louis Bherer, Martin Juneau, Joffrey Drigny, Olivier Dupuy, Gabriel Lapierre, Véronique Labelle, Annik Fortier, Anil Nigam
Chronic exercise has been shown to prevent or slow age-related decline in cognitive functions in otherwise healthy, asymptomatic individuals. We sought to assess cognitive function in a stable coronary heart disease (CHD) sample and its relationship to cerebral oxygenation-perfusion, cardiac hemodynamic responses, and [Formula: see text] peak compared to age-matched and young healthy control subjects. Twenty-two young healthy controls (YHC), 20 age-matched old healthy controls (OHC) and 25 patients with stable CHD were recruited...
2017: PloS One
Stéphane Longeville, Laura-Roxana Stingaciu
Translational diffusion of macromolecules in cell is generally assumed to be anomalous due high macromolecular crowding of the milieu. Red blood cells are a special case of cells filled quasi exclusively (95% of the dry weight of the cell) with an almost spherical protein: hemoglobin. Hemoglobin diffusion has since a long time been recognized as facilitating the rate of oxygen diffusion through a solution. We address in this paper the question on how hemoglobin diffusion in the red blood cells can help the oxygen capture at the cell level and hence to improve oxygen transport...
September 5, 2017: Scientific Reports
Huimin Liu, Fang Dong, Guangquan Li, Ming Niu, Congen Zhang, Yanzhong Han, Lanzhi He, Ping Yin, Bin Wang, Xiuxiu Sang, Ruishen Li, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao
ETHNOPHARMACOLOGICAL RELEVANCE: Liuweiwuling (LWWL) tablets contain a six-herb Chinese formula and are commonly prescribed to facilitate nourishment of the liver and kidneys, clear away toxic materials and activate blood circulation. Administration of LWWL is well known for its protective effects on the liver and its capacity to confer long-term stability in patients exhibiting reduced transaminase levels. Clinical studies have reported that LWWL can also be used for the treatment of liver fibrosis with associated treatment regimens resulting in a concomitant reduction in transforming growth factor β1 (TGF-β1) levels in the serum of patients with hepatic fibrosis...
August 31, 2017: Journal of Ethnopharmacology
Gabriela E Viacava, Sara I Roura, Luis A Berrueta, Carmen Iriondo, Blanca Gallo, Rosa M Alonso-Salces
Lettuce (Lactuca sativa) is one of the most popular leafy vegetables in the world and constitutes a major dietary source of phenolic compounds with health promoting properties. In particular, the demand for green and red oak-leaf lettuces have considerably increased in the last years but few data on their polyphenol composition is available. Moreover, the utilization of analytical edge technology can provide new structural information and allow the identification of unknown polyphenols. In the present study the phenolic profiles of green and red oak-leaf lettuce cultivars were exhaustively characterized by ultrahigh performance liquid chromatography (UHPLC) coupled online to diode array detection (DAD), electrospray ionization (ESI) and quadrupole time-of-flight mass spectrometry (QToF/MS), using the MS(E) instrument acquisition mode for recording simultaneously exact masses of precursor and fragment ions...
August 22, 2017: Journal of Mass Spectrometry: JMS
Elia Matteucci, Andrea Baschieri, Andrea Mazzanti, Letizia Sambri, Jorge Ávila, Antonio Pertegás, Henk J Bolink, Filippo Monti, Enrico Leoni, Nicola Armaroli
A series of monoanionic Ir(III) complexes (2-4) of general formula [Ir(C^N)2(b-trz)](TBA) are presented, where C^N indicates three different cyclometallating ligands (Hppy = 2-phenylpyridine; Hdfppy = 2-(2,4-difluoro-phenyl)pyridine; Hpqu = 2-methyl-3-phenylquinoxaline), b-trz is a bis-tetrazolate anionic N^N chelator (H2b-trz = di(1H-tetrazol-5-yl)methane), and TBA = tetrabutylammonium. 2-4 are prepared in good yields by means of the reaction of the suitable b-trz bidentate ligand with the desired iridium(III) precursor...
August 22, 2017: Inorganic Chemistry
Ana Elisa Madalena Rinaldi, Wolney Lisboa Conde
OBJECTIVE: To describe dietary patterns (DP) from 1996 to 2006 and in the first 5 years of life and to explore individual and contextual characteristics associated with each DP. DESIGN: DP were defined by principal component analysis. The association between DP and individual (sociodemographic, maternal and child) and contextual (geographic regional and year) characteristics was analysed by multilevel analysis. SETTING: Two complex probabilistic Brazilian Demographic and Health Surveys (BDHS 1996, 2006)...
August 15, 2017: Public Health Nutrition
Maksym V Kovalenko, Maryna I Bodnarchuk
Lead halide perovskites (LHPs) of the general formula APbX3 (A=Cs+, CH3NH3+, or CH(NH2)2+; X=Cl, Br, or I) have recently emerged as a unique class of low-cost, versatile semiconductors of high optoelectronic quality. These materials offer exceptionally facile solution-based engineerability in the form of bulk single crystals, thin films, or supported and unsupported nanostructures. The lattermost form, especially as colloidal nanocrystals (NCs), holds great promise as a versatile photonic source, operated via bright photoluminescence (PL) in displays or lighting (energy down-conversion of blue light into green and red), or via electroluminescence in light-emitting diodes...
August 9, 2017: Chimia
Yang Yang, Liangming Zhang, Bin Liu, Mao Pang, Peigen Xie, Zihao Chen, Wenbin Wu, Feng Feng, Limin Rong
BACKGROUND: Hidden haemorrhage has been proved to be significant in joint surgery. However, when referring to lumbar interbody fusion, it is often ignored because of its invisibility. This randomized controlled study aimed to calculate and compare hidden haemorrhage following minimally invasive and open transforaminal lumbar interbody fusion (MIS-TLIF and open TLIF). Meanwhile, its clinical significance was also analyzed. MATERIALS AND METHODS: A total of 41 patients were included in this study, then they were randomized to receive MIS-TLIF or open TLIF, 21 and 20, respectively...
July 24, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
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