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https://www.readbyqxmd.com/read/29351309/a-modified-elliptical-formula-to-estimate-kidney-collagen-content-in-a-model-of-chronic-kidney-disease
#1
Jake A Nieto, Janice Zhu, Bin Duan, Jingsong Li, Ping Zhou, Latha Paka, Michael A Yamin, Itzhak D Goldberg, Prakash Narayan
The extent of scarring or renal interstitial collagen deposition in chronic kidney disease (CKD) can only be ascertained by highly invasive, painful and sometimes risky, tissue biopsy. Interestingly, while CKD-related abnormalities in kidney size can often be visualized using ultrasound, not only does the ellipsoid formula used today underestimate true renal size, but the calculated renal size does not inform tubulointerstitial collagen content. We used coronal kidney sections from healthy mice and mice with kidney disease to develop a new formula for estimating renal parenchymal area...
2018: PloS One
https://www.readbyqxmd.com/read/29333614/the-effect-of-risk-factor-misclassification-on-the-partial-population-attributable-risk
#2
Benedict H W Wong, Sarah B Peskoe, Donna Spiegelman
The partial population attributable risk (pPAR) is used to quantify the population-level impact of preventive interventions in a multifactorial disease setting. In this paper, we consider the effect of nondifferential risk factor misclassification on the direction and magnitude of bias of pPAR estimands and related quantities. We found that the bias in the uncorrected pPAR depends nonlinearly and nonmonotonically on the sensitivities, specificities, relative risks, and joint prevalence of the exposure of interest and background risk factors, as well as the associations between these factors...
January 15, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29326805/detection-of-%C3%AE-thalassemia-carriers-by-red-cell-parameters-obtained-from-automatic-counters-using-mathematical-formulas
#3
Idit Lachover Roth, Boaz Lachover, Guy Koren, Carina Levin, Luci Zalman, Ariel Koren
Background: β-thalassemia major is a severe disease with high morbidity. The world prevalence of carriers is around 1.5-7%. The present study aimed to find a reliable formula for detecting β-thalassemia carriers using an extensive database of more than 22,000 samples obtained from a homogeneous population of childbearing age women with 3161 (13.6%) of β-thalassemia carriers and to check previously published formulas. Methods: We applied a mathematical method based on the support vector machine (SVM) algorithm in the search for a reliable formula that can differentiate between thalassemia carriers and non-carriers, including normal counts or counts suspected to belong to iron-deficient women...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29316805/red-pepper-seed-inhibits-differentiation-of-3t3-l1-cells-during-the-early-phase-of-adipogenesis-via-the-activation-of-ampk
#4
Hwa-Jin Kim, Mi-Kyoung You, Ziyun Wang, Hyeon-A Kim
Obesity is the main risk factor for metabolic syndromes and there has been an upsurge in demand for effective therapeutic strategies. This study investigated the effect of red pepper seed water extract (RPS) on the process of differentiation in 3T3-L1 adipocytes. RPS treatment significantly suppressed cellular lipid accumulation and reduced the expression of adipocytes-associated proteins, peroxisome proliferator-activated receptor-[Formula: see text] (PPAR-[Formula: see text]), CCAAT/enhancer-binding proteins [Formula: see text] (C/EBP [Formula: see text]), sterol regulatory element binding protein-1c (SREBP-1c), as well as fatty acid synthase (FAS), and fatty acid binding protein 4 (FABP4)...
January 9, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29300489/itraq-based-proteomic-analysis-reveals-recovery-of-impaired-mitochondrial-function-in-ischemic-myocardium-by-shenmai-formula
#5
Yi Wang, Yu Zhao, Wei Jiang, Xiaoping Zhao, Guanwei Fan, Han Zhang, Peiqiang Shen, Jiangmin He, Xiaohui Fan
Shenmai formula (SM) is a traditional medicinal remedy for treating cardiovascular diseases in China since 800 years ago, however its mechanism of action remains unclear. To explore the mechanism underlying cardioprotective effects of SM, iTRAQ-based proteomic approach was applied to analyze protein of myocardium in rats with myocardial ischemic injury. Upon treatment with SM and its two major components Red ginseng (RG) and Radix Ophiopogonis (OP), 101 differentially expressed proteins were filtered from a total of 711 detected and annotated proteins...
January 4, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29284957/color-stability-assessment-of-two-different-composite-resins-with-variable-immersion-time-using-various-beverages-an-in-vitro-study
#6
M Senthil Kumar, R Ajay, S A Miskeen Sahib, M Chittrarasu, M Navarasu, N Ragavendran, Omar Farooq Burhanuddin Mohammed
Purpose of the Study: The aim of the study was to evaluate the difference in the color of microhybrid (MH) and nanofilled (NF) composite resins after 24 and 48 h in beverages such as red wine (RW), Coca-Cola, and distilled water. The specific objective of this study was to investigate the cumulative effect of the colorant solutions on the dental composites. Materials and Methods: MH and NF composite resins (A2 shade) were used in this current study. Sixty disk-shaped material specimens (10 mm in diameter × 2 mm in thickness) were prepared using a fiber mold (ring), with the desired dimensions...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29260174/isostructural-lanthanide-based-metal-organic-frameworks-structure-photoluminescence-and-magnetic-properties
#7
Li-Lin Luo, Xiang-Long Qu, Zheng Li, Xia Li, Hao-Ling Sun
A series of the anhydrous lanthanide-based metal-organic frameworks (Ln-MOFs) were successfully synthesized under hydrothermal conditions of Ln(iii) ions with 3,4'-oxybis(benzoate) (3,4'-oba), oxalate (ox) and 1,10-phenanthroline (phen). Structural analyses revealed that they are isostructural 3D open-frameworks with the formula of [Ln(3,4'-oba) (phen)(ox)0.5]n (Ln = Sm for 1, Eu for 2, Gd for 3, Tb for 4, and Dy for 5) and the topology of {33·43·58·6}. Within the 3D structure, the [LnO6N2] units are bridged by ox to form [Ln2ox] dimers and then are further connected by 3,4'-oba ligands...
December 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29258500/anti-adipogenic-effects-of-the-traditional-herbal-formula-dohongsamul-tang-in-3t3-l1-adipocytes
#8
Eun Hyoung Shim, Hoyoung Lee, Myeong Soo Lee, Sooseong You
BACKGROUND: Blood stasis syndrome (BSS) is a general pattern identification and refers to pathological stagnation of blood circulation, dysfunction of endothelial cells or metabolic disorder in traditional Korean medicine (TKM). Dohongsamul-Tang (DHSMT) is a well-known traditional herbal formula which used for treatment and prevention of BSS by promoting blood circulation in TKM. METHODS: Cytotoxicity of DHSMT was examined by cell counting kit-8 (CCK-8). We also investigated the anti-adipogenesis effect of DHSMT by using Oil Red O staining, intracellular triglyceride assay leptin ELISA and western blot analysis in 3T3-L1 adipocytes...
December 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29244753/identification-of-a-multicomponent-traditional-herbal-medicine-by-hplc-ms-and-electron-and-light-microscopy
#9
Ju-Han Liu, Yung-Yi Cheng, Chen-Hsi Hsieh, Tung-Hu Tsai
BACKGROUND: Commercial pharmaceutical herbal products have enabled people to take traditional Chinese medicine (TCM) in a convenient and accessible form. However, the quantity and quality should be additionally inspected. To address the issue, a combination of chemical and physical inspection methods were developed to evaluate the amount of an herbal formula, Xiang-Sha-Liu-Jun-Zi-Tang (XSLJZT), in clinical TCM practice. METHODS: A high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS) method with electrospray ionization was developed to measure the herbal biomarkers of guanosine, atractylenolide III, glycyrrhizic acid, dehydrocostus lactone, hesperidin, and oleanolic acid from XSLJZT...
December 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29221059/metallic-fresnel-zone-plate-implemented-on-an-optical-fiber-facet-for-super-variable-focusing-of-light
#10
Hyuntai Kim, Jinseob Kim, Haechan An, Yohan Lee, Gun-Yeal Lee, Jeongkyun Na, Kyoungyoon Park, Seungjong Lee, Seung-Yeol Lee, Byoungho Lee, Yoonchan Jeong
We propose and investigate a metallic Fresnel zone plate (FZP/MFZP) implemented on a silver-coated optical fiber facet for super-variable focusing of light, the focal point of which can be drastically relocated by varying the wavelength of the incident light. We numerically show that when its nominal focal length is set to 20 μm at 550 nm, its effective focal length can be tuned by ~13.7 μm for 300-nm change in the visible wavelength range. This tuning sensitivity is over 20 times higher than that of a conventional silica-based spherical lens...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29194422/food-and-nutrient-intake-and-nutrient-sources-in-1-year-old-infants-in-finland-a-cross-sectional-analysis
#11
Helena H Hauta-Alus, Liisa Korkalo, Elisa M Holmlund-Suila, Jenni Rosendahl, Saara M Valkama, Maria Enlund-Cerullo, Otto M Helve, Timo K Hytinantti, Outi M Mäkitie, Sture Andersson, Heli T Viljakainen
The infant diet has short- and long-term health consequences. Updated data regarding the dietary intake of Finnish infants are lacking. The objectives of this study were to describe infant food and nutrient intake and to identify food sources of the nutrients. Altogether, 739 healthy infants were studied. Dietary intake and breastfeeding frequency were assessed with a three-day food record at 1 year of age. Dietary intake was calculated separately for non-breastfed and breastfed infants. One-third (36%) of the infants were partially breastfed and 95% consumed mass-produced baby foods...
December 1, 2017: Nutrients
https://www.readbyqxmd.com/read/29181427/effect-of-short-term-colored-light-exposure-on-cerebral-hemodynamics-and-oxygenation-and-systemic-physiological-activity
#12
Felix Scholkmann, Timo Hafner, Andreas Jaakko Metz, Martin Wolf, Ursula Wolf
There is not yet a comprehensive view of how the color of light affects the cerebral and systemic physiology in humans. The aim was to address this deficit through basic research. Since cerebral and systemic physiological parameters are likely to interact, it was necessary to establish an approach, which we have termed "systemic-physiology-augmented functional near-infrared spectroscopy (SPA-fNIRS) neuroimaging." This multimodal approach measures the systemic and cerebral physiological response to exposure to light of different colors...
October 2017: Neurophotonics
https://www.readbyqxmd.com/read/29168757/off-nadir-hyperspectral-sensing-for-estimation-of-vertical-profile-of-leaf-chlorophyll-content-within-wheat-canopies
#13
Weiping Kong, Wenjiang Huang, Raffaele Casa, Xianfeng Zhou, Huichun Ye, Yingying Dong
Monitoring the vertical profile of leaf chlorophyll (Chl) content within winter wheat canopies is of significant importance for revealing the real nutritional status of the crop. Information on the vertical profile of Chl content is not accessible to nadir-viewing remote or proximal sensing. Off-nadir or multi-angle sensing would provide effective means to detect leaf Chl content in different vertical layers. However, adequate information on the selection of sensitive spectral bands and spectral index formulas for vertical leaf Chl content estimation is not yet available...
November 23, 2017: Sensors
https://www.readbyqxmd.com/read/29150729/effect-of-microemulsion-structure-on-fluorescence-and-nonlinear-optical-properties-of-rhodamine-6g
#14
M Pourtabrizi, N Shahtahmassebi, A Kompany, S Sharifi
This study is conducted to investigate the effect of nano-droplets concentration and size on linear and nonlinear optical properties of Rhodamine 6G by UV-Vis, spectrofluorometer and Z-Scan techniques. Nano-droplets were prepared by mixture of AOT, n-Decane and Water at three different water to surfactant molar ratios (W = 3, 6.7 and 40) and two dye to water mass ratios (R). At high enough dye concentration, the fluorescence intensity and its red shift depend on the concentration of dye in water nano-droplets (R)...
November 18, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/29146940/development-and-physiological-effects-of-an-artificial-diet-for-wolbachia-infected-aedes-aegypti
#15
Heverton Leandro Carneiro Dutra, Silvia Lomeu Rodrigues, Simone Brutman Mansur, Sofia Pimenta de Oliveira, Eric Pearce Caragata, Luciano Andrade Moreira
The endosymbiotic bacterium Wolbachia spreads rapidly through populations of Aedes aegypti mosquitoes, and strongly inhibits infection with key human pathogens including the dengue and Zika viruses. Mosquito control programs aimed at limiting transmission of these viruses are ongoing in multiple countries, yet there is a dearth of mass rearing infrastructure specific to Wolbachia-infected mosquitoes. One example is the lack of a blood meal substitute, which accounts for the Wolbachia-specific physiological changes in infected mosquitoes, that allows the bacterium to spread, and block viral infections...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29128416/efficacy-and-safety-of-the-topical-application-of-tranexamic-acid-in-primary-cementless-hip-arthroplasty-prospective-randomised-double-blind-and-controlled-study
#16
F J Tavares Sánchez-Monge, I Aguado Maestro, A Bañuelos Díaz, M Á Martín Ferrero, M F García Alonso
OBJECTIVE: To evaluate the efficacy of topical tranexamic acid topical in cementless total hip arthroplasty from the point of view of bleeding, transfusion requirements and length of stay, and describe the complications of use compared to a control group. MATERIAL AND METHODS: A prospective, randomised, double-blinded and controlled study including all patients undergoing cementless total hip arthroplasty in our centre between June 2014 and July 2015. Blood loss was estimated using the formula described by Nadler and Good...
November 8, 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29118560/the-effectiveness-of-intravenous-iron-for-iron-deficiency-anemia-in-gastrointestinal-cancer-patients-a-retrospective-study
#17
Laurens Verhaeghe, Luk Bruyneel, Elisabeth Stragier, Marc Ferrante, Daan Dierickx, Hans Prenen
Background: Knowledge of the role of intravenous iron without the use of additional erythropoietic stimulating agents in anemic cancer patients is limited. This study evaluated the effect of ferric carboxymaltose (FCM) in a group of digestive oncology (DIO) patients and aimed to differentiate therapy response according to different types of iron deficiency (ID) anemia. Methods: In this retrospective study, we identified DIO patients who were receiving FCM and had eligible baseline and follow-up hemoglobin (Hb) levels that did not require red blood cell transfusion...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29095449/exploring-the-localized-to-delocalized-transition-in-non-symmetric-bimetallic-ruthenium-polypyridines
#18
Paola S Oviedo, German E Pieslinger, Alejandro Cadranel, Luis M Baraldo
In this work, we report the evolution of the properties of the inter-valence charge transfer (IVCT) transition in a family of cyanide-bridged ruthenium polypyridines of general formula [Ru(II)(tpy)(bpy)(μ-CN)Ru(III)(bpy)2(L)](3/4+) (tpy = 2,2',6',2''-terpyridine; bpy = 2,2'-bipyridine; L = Cl(-), NCS(-), 4-dimethylaminopyridine or acetonitrile). In these complexes, the redox potential difference between both ruthenium centers (ΔE) is systematically modified. A decrease in ΔE causes a red shift of the energy and an intensity enhancement of the observed IVCT transitions...
November 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29095037/the-heat-strain-of-various-athletic-surfaces-a-comparison-between-observed-and-modeled-wet-bulb-globe-temperatures
#19
J Luke Pryor, Riana R Pryor, Andrew Grundstein, Douglas J Casa
CONTEXT:   The National Athletic Trainers' Association recommends using onsite wet-bulb globe temperature (WBGT) measurement to determine whether to modify or cancel physical activity. However, not all practitioners do so and instead they may rely on the National Weather Service (NWS) to monitor weather conditions. OBJECTIVE:   To compare regional NWS WBGT estimates with local athletic-surface readings and compare WBGT measurements among various local athletic surfaces...
November 2, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/29038374/early-spectra-of-the-gravitational-wave-source-gw170817-evolution-of-a-neutron-star-merger
#20
B J Shappee, J D Simon, M R Drout, A L Piro, N Morrell, J L Prieto, D Kasen, T W-S Holoien, J A Kollmeier, D D Kelson, D A Coulter, R J Foley, C D Kilpatrick, M R Siebert, B F Madore, A Murguia-Berthier, Y-C Pan, J X Prochaska, E Ramirez-Ruiz, A Rest, C Adams, K Alatalo, E Bañados, J Baughman, R A Bernstein, T Bitsakis, K Boutsia, J R Bravo, F Di Mille, C R Higgs, A P Ji, G Maravelias, J L Marshall, V M Placco, G Prieto, Z Wan
On 17 August 2017, Swope Supernova Survey 2017a (SSS17a) was discovered as the optical counterpart of the binary neutron star gravitational wave event GW170817. We report time-series spectroscopy of SSS17a from 11.75 hours until 8.5 days after merger. Over the first hour of observations the ejecta rapidly expanded and cooled. Applying blackbody fits to the spectra, we measure the photosphere cooling from [Formula: see text] K to [Formula: see text] K, and determine a photospheric velocity of roughly 30% of the speed of light...
October 16, 2017: Science
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