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Asthma obesity

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https://www.readbyqxmd.com/read/29453208/parent-reported-prevalence-and-persistence-of-19-common-child-health-conditions
#1
Tracy Liu, Raghu Lingam, Kate Lycett, Fiona K Mensah, Joshua Muller, Harriet Hiscock, Md Hamidul Huque, Melissa Wake
OBJECTIVE: To estimate prevalence and persistence of 19 common paediatric conditions from infancy to 14-15 years. DESIGN: Population-based prospective cohort study. SETTING: Australia. PARTICIPANTS: Parallel cohorts assessed biennially from 2004 to 2014 from ages 0-1 and 4-5 years to 10-11 and 14-15 years, respectively, in the Longitudinal Study of Australian Children. MAIN OUTCOME MEASURES: 19 health conditions: 17 parent-reported, 2 (overweight/obesity, obesity) directly assessed...
February 16, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29452277/association-between-obesity-and-acute-severity-among-patients-hospitalized-for-asthma-exacerbation
#2
Sarah Kyuragi Luthe, Atsushi Hirayama, Tadahiro Goto, Mohammad Kamal Faridi, Carlos A Camargo, Kohei Hasegawa
BACKGROUND: Although studies have demonstrated relations between obesity and incident asthma, little is known about the association of obesity with acute severity in adults hospitalized for asthma exacerbation. OBJECTIVES: To investigate the association of obesity with acute severity of asthma exacerbation. METHODS: This is a retrospective cohort study using population-based data of 8 geographically diverse US states from 2010 through 2013...
February 13, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29446981/diet-pattern-and-respiratory-morbidity-in-the-atherosclerosis-risk-in-communities-study
#3
Emily P Brigham, Lyn M Steffen, Stephanie J London, Danielle Boyce, Gregory B Diette, Nadia N Hansel, Jessica Rice, Meredith C McCormack
RATIONALE: Dietary intake is a potential risk factor for respiratory morbidity in adult populations. Few studies capture the effect of diet patterns, representative of combination of nutrients consumed, on respiratory morbidity in combination with objective measures of lung function. OBJECTIVES: To evaluate patterns of dietary intake in relation to respiratory morbidity and objective measures of lung function in a U.S. POPULATION: <AbstractText Label="METHODS" NlmCategory="METHODS">The Atherosclerosis Risk in Communities (ARIC) Study enrolled 15,792 participants from four U...
February 15, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29445341/celastrol-alleviates-airway-hyperresponsiveness-and-inhibits-th17-responses-in-obese-asthmatic-mice
#4
Zeyu Zeng, Xixi Lin, Rongying Zheng, Hui Zhang, Weixi Zhang
Severe airway hyperresponsiveness (AHR) is a clinical feature of asthma, which has been associated with obesity and has shown a poor response to standard asthma treatments such as glucocorticoids. Numerous studies have shown that Interleukin (IL)-17 producing CD4 + T cells (Th17 cells), which could be inhibited by celastrol, is essential in mediating steroid-resistant AHR. The following study investigates the impact of celastrol and its mechanism on the regulation of AHR in murine model of obesity and asthma...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29432326/exercise-improves-physical-activity-and-comorbidities-in-obese-adults-with-asthma
#5
Patrícia Duarte Freitas, Aline Grandi Silva, Palmira Gabriele Ferreira, Analuci da Silva, João Marcos Salge, Regina Maria Carvalho-Pinto, Alberto Cukier, Claudia M Brito, Marcio C Mancini, Celso R F Carvalho
INTRODUCTION: Obese adults with asthma have an increased number of comorbidities and reduced daily life physical activity (DLPA), which may worsen asthma symptoms. Exercise is recommended to improve asthma outcomes; however, the benefits of exercise for psychosocial comorbidities and physical activity levels in obese adults with asthma have been poorly investigated. OBJECTIVE: To assess the effects of exercise on DLPA, asthma symptoms and psychosocial comorbidities in obese adults with asthma...
February 9, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29432207/prevalence-of-comorbid-conditions-pre-existing-and-diagnosed-at-a-tertiary-care-pediatric-weight-management-clinic
#6
Griselle Leon, Elizabeth de Klerk, Josephine Ho, Michelle Jackman, Raylene A Reimer, Kimberly E Connors, Paola Luca
BACKGROUND: Childhood obesity places individuals at risk for a multitude of physical and mental health problems. The aim of this study was to assess the prevalence of obesity related comorbidities diagnosed prior to and after attending a tertiary care pediatric weight management clinic. METHODS: A cross sectional retrospective chart review of patients 2-17 years old seen in the weight management clinic at Alberta Children's Hospital from May 2012 to May 2014. RESULTS: A total of 199 patients were included in the review...
February 13, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29427767/an-assessment-of-the-relationship-of-physical-activity-obesity-and-chronic-diseases-conditions-between-active-obese-and-sedentary-normal-weight-american-women-in-a-national-sample
#7
J R Pharr, C A Coughenour, T J Bungum
OBJECTIVE: Obesity and physical inactivity are associated with increased rates of chronic diseases and conditions. However, the 'fit but fat' theory posits that cardiopulmonary fitness (or physical activity) can mitigate risks to health associated with obesity. The purpose of this study was to compare chronic diseases and conditions of highly active/obese women with inactive/normal weight women. STUDY DESIGN: This was a cross-sectional study of the 2015 Behavioral Risk Factor Surveillance System data...
February 7, 2018: Public Health
https://www.readbyqxmd.com/read/29422824/the-relationship-between-body-mass-index-and-increased-airway-reactivity-based-on-methacholine-challenge-test-results
#8
Maryam Haddadzadeh Shoshtari, Hossein Tahmasbian Malayeri, Hadi Shahrad Bejestani
Introduction: According to the reports of the United States National Bureau of Statistics regarding the prevalence of obesity among adults and children and also asthma outbreak, the relationship between asthma and obesity in developed countries is taken into consideration. Aim: Relationship between body mass index and increased airway reactivity based on methacholine challenge test results. Material and methods: It was a retrospective cross-sectional study done on 256 patients who were referred to the lung clinic of the Imam Khomeini Hospital of Ahvaz with symptoms of hypersensitivity of the airways...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29420086/a-review-of-obesity-and-asthma-across-the-life-span
#9
Faiza Khalid, Fernando Holguin
OBJECTIVE: This literature review aims to compare obese-asthmatic adults and children, and to characterize differences and similarities between the two subgroups from epidemiological, demographical, phenotypical, and physiological perspectives. METHODS: Literature search was conducted using Pubmed database with "obesity," "asthma," "epidemiology," "cluster analysis," "demography," "mechanics," and ''FeNO'' as search terms. METHODS: Articles investigating epidemiological, demographic, phenotypical variation, and mechanical aspects of breathing specifically in obese asthmatics were identified...
February 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29414651/high-fat-diet-induces-airway-hyperresponsiveness-partly-through-activating-cd38-signaling-pathway
#10
Lei Chong, Weixi Zhang, Gang Yu, Hailin Zhang, Lili Zhu, Haiyan Li, Youyou Shao, Changchong Li
CD38 is a plasma membrane bound multifunctional enzyme. It can be activated by inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-13, inducing calcium responses to agonist in airway smooth muscle cells (ASMC). Previous studies have found that high-fat-diet (HFD) induced obesity exhibited innate airway hyperresponsiveness (AHR). This study aimed to detect the effect of CD38 signaling pathway on the AHR of overweight/obese mice. The HFD-fed mice exhibited a significantly higher baseline airway resistance (Rn), and the increasing rates of Rn responded to increasing doses of methacholine compared with the LFD-fed mice...
February 1, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29410479/the-efficacy-of-a-high-protein-low-glycemic-index-diet-intervention-in-non-obese-patients-with-asthma
#11
Nina Rica Wium Geiker, Louise L Toennesen, Arne Astrup, Vibeke Backer
BACKGROUND/OBJECTIVES: EFFORT Asthma study is a randomized controlled trial designed to assess the effects of diet and exercise in non-obese, untrained patients with asthma. We here present results from a subgroup of participants in the diet and control group to assess the feasibility of a high protein and low glycemic index (GI) diet and the effects on body composition. SUBJECTS/METHODS: Of the 149 subjects who were included in the study, 76 subjects (30 males) were randomized into either a diet group (n = 38) or a control group (n = 38) and included in the present analysis...
February 6, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29410044/biomarkers-in-obese-asthma-age-of-asthma-onset-matters
#12
Guus A Westerhof, Hanneke Coumou, Elisabeth H D Bel
No abstract text is available yet for this article.
February 1, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29408186/physical-activity-correlates-in-people-with-mild-cognitive-impairment-findings-from-six-low-and-middle-income-countries
#13
D Vancampfort, E Lara, B Stubbs, N Swinnen, M Probst, A Koyanagi
OBJECTIVES: Despite promising research showing that physical activity (PA) might improve cognitive functioning in people with mild cognitive impairment (MCI), people with MCI are less physically active compared with the general population. Therefore, the aim of this study was to assess PA correlates among community-dwelling older people with MCI in six low- and middle-income countries. DESIGN: Cross-sectional data from the World Health Organization's Study on Global Ageing and Adult Health were analysed...
February 1, 2018: Public Health
https://www.readbyqxmd.com/read/29395935/factors-reducing-omalizumab-response-in-severe-asthma
#14
B Sposato, M Scalese, M Milanese, S Masieri, C Cavaliere, M Latorre, N Scichilone, A Matucci, A Vultaggio, A Ricci, A Cresti, P Santus, A Perrella, P L Paggiaro
BACKGROUND: Despite adding Omalizumab to conventional therapy, several severe asthmatics still show poor disease control. We investigated the factors that may affect a reduced Omalizumab response in a large population of severe asthmatics. METHODS: 340 patients were retrospectively evaluated. FEV1%, FVC%, Asthma Control Test (ACT), fractional exhaled nitric oxide (FENO), possible step-downs/step-ups of concomitant therapies, exacerbations, disease control levels, ICS doses and SABA use, observed at the end of treatment, were considered as a response to Omalizumab...
January 29, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29394961/effects-of-coexisting-asthma-and-obstructive-sleep-apnea-on-sleep-architecture-oxygen-saturation-and-systemic-inflammation-in-women
#15
Fredrik Sundbom, Christer Janson, Andrei Malinovschi, Eva Lindberg
STUDY OBJECTIVES: Both asthma and obstructive sleep apnea (OSA) are strongly associated with poor sleep. Asthma and OSA also have several features in common, including airway obstruction, systemic inflammation, and an association with obesity. The aim was to analyze the effect of asthma, OSA, and the combination of asthma and OSA on objectively measured sleep quality and systemic inflammation. METHODS: Sleep and health in women is an ongoing community-based study in Uppsala, Sweden...
February 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29383778/obese-asthmatics-are-characterised-by-altered-adipose-tissue-macrophage-activation
#16
Hashim A Periyalil, Lisa G Wood, Timothy A Wright, Constantin Karihaloo, Malcolm R Starkey, April S Miu, Katherine J Baines, Philip M Hansbro, Peter G Gibson
Adipose tissue-derived inflammation is linked to obesity-related co-morbidities. This study aimed to quantify and immuno-phenotype adipose tissue macrophages (ATMs) from obese asthmatics and obese non-asthmatics, and to examine associations between adipose tissue, systemic and airway inflammation. Visceral (VAT) and sub-cutaneous (SAT) adipose tissue were collected from obese adults undergoing bariatric surgery and processed to obtain the stromovascular fraction. Pro- (M1) and anti-inflammatory (M2) macrophages were quantified by flow cytometry...
January 31, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29382592/the-obese-asthma-phenotype-in-children-an-exacerbating-situation
#17
Cristina Longo, Gillian Bartlett, Tibor Schuster, Francine M Ducharme, Brenda MacGibbon, Tracie A Barnett
BACKGROUND: Current evidence regarding the relationship between childhood obesity, decreased response to inhaled corticosteroids (ICS), and poor asthma control is conflicting. OBJECTIVES: We assessed if obesity: i) is associated with time-to-first exacerbation among children with asthma initiating Step-3 maintenance therapies; ii) modifies the effectiveness of Step-3 therapies. METHODS: A retrospective cohort study was conducted from clinical data linked to health and drug administrative databases...
January 27, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29380115/effects-of-diet-induced-obesity-on-tracheal-responsiveness-to-methacholine-tracheal-visfatin-level-and-lung-histological-changes-in-ovalbumin-sensitized-female-wistar-rats
#18
Rana Keyhanmanesh, Mohammad Reza Alipour, Hadi Ebrahimi, Mohammad Reza Aslani
Many studies have shown a close relationship between obesity and asthma severity. In the present study, the effects of diet-induced obesity were examined on airway responsiveness to methacholine in addition to visfatin level in female Wistar rats' tracheae after sensitization with ovalbumin. The rats were divided into four groups: control with normal diet (ND), ovalbumin (OVA)-sensitized with normal diet (S + ND), high-fat diet (HFD), and OVA-sensitized with a high-fat diet (S + HFD). The animals were fed for 8 weeks with standard pelts or high-fat diet and then sensitized and challenged with OVA or saline for another 4 weeks...
January 29, 2018: Inflammation
https://www.readbyqxmd.com/read/29375882/idiopathic-intracranial-hypertension-as-a-presenting-sign-of-adrenal-insufficiency
#19
Sandra Shenouda, Khaled Al-Farawi, Jenna Dolan, Susan L Flesher
Idiopathic intracranial hypertension is a diagnosis of exclusion defined by elevated intracranial pressure without mass lesions or hydrocephalus. Causes of idiopathic intracranial hypertension include obesity, vitamin derangements, antibiotics, corticosteroids, and autoimmune disorders. Cushing's disease and Addison's disease have been associated with idiopathic intracranial hypertension. Secondary adrenal insufficiency following withdrawal of inhaled corticosteroids has been found to be a relatively common phenomenon...
2018: SAGE open medical case reports
https://www.readbyqxmd.com/read/29373330/the-importance-of-cohort-research-starting-early-in-life-to-understanding-child-health
#20
Nigel Paneth, Catherine Monk
PURPOSE OF REVIEW: The current review addresses the importance of the prospective cohort design in large, unselected populations starting early in life for understanding the origins of childhood health disorders. RECENT FINDINGS: Cohort studies originating in healthy populations have contributed to great advances in health, especially in cardiovascular diseases, but have only recently been applied systematically to study the origins of childhood disorders. Several large population-based pregnancy and/or birth cohorts have been developed in different parts of the world, and these are beginning to contribute to better understanding of the underlying causes of rare but important childhood disorders, such as autism...
January 25, 2018: Current Opinion in Pediatrics
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