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Asthma obesity

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https://www.readbyqxmd.com/read/28220767/asthma-control-in-adult-patients-treated-with-a-combination-of-inhaled-corticosteroids-and-long-acting-beta-2-agonists-a-prospective-observational-study
#1
Barbara Rogala, Paweł Majak, Joanna Glück, Tomasz Dębowski
INTRODUCTION    Asthma is a highly prevalent disease that often requires maintenance therapy. Combined inhaled corticosteroid and long-acting beta-2 agonist (ICS/LABA) inhalers are one of the available maintenance treatment options.  OBJECTIVES    This prospective observational study aimed to assess asthma control in patients treated with ICS/LABA inhalers and to identify factors related to controlled asthma. PATIENTS AND METHODS    A total of 5789 asthma sufferers from Poland were enrolled in a prospective, observational study and treated with one of the following combined ICS/LABA inhalers at clinically appropriate doses: beclomethasone/formoterol, fluticasone/salmeterol, or budesonide/formoterol...
January 18, 2017: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/28197893/gender-differences-in-clinical-and-polysomnographic-features-of-obstructive-sleep-apnea-a-clinical-study-of-2827-patients
#2
Ozen K Basoglu, Mehmet Sezai Tasbakan
PURPOSE: Obstructive sleep apnea (OSA) is underdiagnosed in females due to different clinical presentation. We aimed to determine the effect of gender on clinical and polysomnographic features and identify predictors of OSA in women. METHODS: Differences in demographic, clinical, and polysomnographic parameters between 2052 male and 775 female OSA patients were compared. RESULTS: In female OSA patients, age (56.1 ± 9.7 vs. 50.4 ± 11...
February 14, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28185594/sleep-apnoea-in-australian-men-disease-burden-co-morbidities-and-correlates-from-the-australian-longitudinal-study-on-male-health
#3
Chamara Visanka Senaratna, Dallas R English, Dianne Currier, Jennifer L Perret, Adrian Lowe, Caroline Lodge, Melissa Russell, Sashane Sahabandu, Melanie C Matheson, Garun S Hamilton, Shyamali C Dharmage
BACKGROUND: Obstructive sleep apnoea is a common disorder with under-rated clinical impact, which is increasingly being recognised as having a major bearing on global disease burden. Men are especially vulnerable and become a priority group for preventative interventions. However, there is limited information on prevalence of the condition in Australia, its co-morbidities, and potential risk factors. METHODS: We used data from 13,423 adult men included in the baseline wave of Ten to Men, an Australian national study of the health of males, assembled using stratified cluster sampling with oversampling from rural and regional areas...
October 31, 2016: BMC Public Health
https://www.readbyqxmd.com/read/28166215/genetic-loci-associated-with-chronic-obstructive-pulmonary-disease-overlap-with-loci-for-lung-function-and-pulmonary-fibrosis
#4
Brian D Hobbs, Kim de Jong, Maxime Lamontagne, Yohan Bossé, Nick Shrine, María Soler Artigas, Louise V Wain, Ian P Hall, Victoria E Jackson, Annah B Wyss, Stephanie J London, Kari E North, Nora Franceschini, David P Strachan, Terri H Beaty, John E Hokanson, James D Crapo, Peter J Castaldi, Robert P Chase, Traci M Bartz, Susan R Heckbert, Bruce M Psaty, Sina A Gharib, Pieter Zanen, Jan W Lammers, Matthijs Oudkerk, H J Groen, Nicholas Locantore, Ruth Tal-Singer, Stephen I Rennard, Jørgen Vestbo, Wim Timens, Peter D Paré, Jeanne C Latourelle, Josée Dupuis, George T O'Connor, Jemma B Wilk, Woo Jin Kim, Mi Kyeong Lee, Yeon-Mok Oh, Judith M Vonk, Harry J de Koning, Shuguang Leng, Steven A Belinsky, Yohannes Tesfaigzi, Ani Manichaikul, Xin-Qun Wang, Stephen S Rich, R Graham Barr, David Sparrow, Augusto A Litonjua, Per Bakke, Amund Gulsvik, Lies Lahousse, Guy G Brusselle, Bruno H Stricker, André G Uitterlinden, Elizabeth J Ampleford, Eugene R Bleecker, Prescott G Woodruff, Deborah A Meyers, Dandi Qiao, David A Lomas, Jae-Joon Yim, Deog Kyeom Kim, Iwona Hawrylkiewicz, Pawel Sliwinski, Megan Hardin, Tasha E Fingerlin, David A Schwartz, Dirkje S Postma, William MacNee, Martin D Tobin, Edwin K Silverman, H Marike Boezen, Michael H Cho
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10(-6)) in 9,498 cases and 9,748 controls. In the combined meta-analysis, we identified 22 loci associated at genome-wide significance, including 13 new associations with COPD. Nine of these 13 loci have been associated with lung function in general population samples, while 4 (EEFSEC, DSP, MTCL1, and SFTPD) are new...
February 6, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28164817/primary-care-issues-in-inner-city-america-and-internationally
#5
REVIEW
Ramon Cancino
Inner-city patient populations are high-risk for poor outcomes, including increased risk of mortality. Barriers to delivering high-quality primary care to inner-city patients include lack of access, poor distribution of primary care providers (PCPs), competing demands, and financial restraints. Health care issues prevalent in this population include obesity, diabetes, cancer screening, asthma, infectious diseases, and obstetric and prenatal care. Population health management and quality improvement (QI) activities must target disparities in care...
March 2017: Primary Care
https://www.readbyqxmd.com/read/28143694/quantitative-computed-tomography-imaging-based-clustering-differentiates-asthmatic-subgroups-with-distinctive-clinical-phenotypes
#6
Sanghun Choi, Eric A Hoffman, Sally E Wenzel, Mario Castro, Sean Fain, Nizar Jarjour, Mark L Schiebler, Kun Chen, Ching-Long Lin
BACKGROUND: Imaging variables including airway diameter, wall thickness and air-trapping have been found to be important metrics when differentiating severe asthmatics from nonsevere asthmatics and healthy subjects. OBJECTIVE: The objective of this study was to identify imaging-based clusters and to explore the association of the clusters with existing clinical metrics. METHODS: We performed an imaging-based cluster analysis using quantitative computed tomography-based structural and functional variables extracted from the respective inspiration and expiration scans of 248 asthmatics...
January 28, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28140475/changes-in-body-mass-index-during-childhood-and-risk-of-various-asthma-phenotypes-a-retrospective-analyse
#7
Julie Chastang, Nour Baiz, Laure Parnet, Jean Sébastien Cadwallader, Frédéric De Blay, Denis Caillaud, Denis André Charpin, John Dwyer, François Lavaud, Chantal Raherison, Gladys Ibanez, Isabella Annesi-Maesano
BACKGROUND: It is known that asthma is related to obesity but also to small birth weight. The objective of the present study was to clarify this issue by assessing the putative relationship between the change between birth and childhood in child's corpulence as assessed by body mass index (BMI) and asthma phenotypes. METHODS: The following status in corpulence were assessed in 7781 schoolchildren using quartile of BMI at birth and at around 10 (9-11years): underweight at birth and at around 10, underweight at birth and overweight at around 10, overweight at birth and underweight at around 10, overweight at birth and at around 10 and the reference group constituted by all the other children in whom corpulence changes were not extreme...
January 31, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28138394/gender-specific-determinants-of-asthma-among-u-s-adults
#8
Rebecca Greenblatt, Omar Mansour, Edward Zhao, Michelle Ross, Blanca E Himes
BACKGROUND: Asthma, a chronic respiratory disease affecting over 18.7 million American adults, has marked disparities by gender, race/ethnicity and socioeconomic status. Our goal was to identify gender-specific demographic and socioeconomic determinants of asthma prevalence among U.S. adults using data from the Behavioral Risk Factors Surveillance System (BRFSS) and the National Health and Nutrition Examination Survey (NHANES). METHODS: Gender-specific regression analyses were performed to model the relationship between asthma prevalence with age, race/ethnicity, income, education level, smoking status, and body mass index (BMI), while taking into account the study designs...
2017: Asthma research and practice
https://www.readbyqxmd.com/read/28135899/insulin-use-increases-risk-of-asthma-but-metformin-use-reduces-the-risk-in-patients-with-diabetes-in-a-taiwanese-population-cohort
#9
Chiung-Zuei Chen, Chih-Hui Hsu, Chung-Yi Li, Tzuen-Ren Hsiue
objective -Recent reports have suggested that insulin promotes airway smooth muscle contraction and enhances airway hyperresponsiveness, which are cardinal features of asthma. In contrast, metformin can reduce both airway inflammatory and remodeling properties. However, these results are all from in vitro and animal studies. This study investigated whether diabetes and various antidiabetic agents associate with the risk of asthma. methods -We used a retrospective population-based cohort study using Taiwan's National Health Insurance claim database from 2000 to 2010 and a Cox proportional hazards regression model to compare the incidence of asthma between patients with diabetes (n = 19,428) and a matched non-diabetic group (n = 38,856)...
January 31, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28131832/treatment-of-obese-asthma-in-a-mouse-model-by-simvastatin-is-associated-with-improving-dyslipidemia-and-decreasing-leptin-level
#10
Wei Han, Jun Li, Huaping Tang, Lixin Sun
Obesity can cause or worsen asthma. Compared with common asthma, obese asthma is difficult to control. Statins are effective serum cholesterol-lowering agents in clinical practice, and they also have anti-inflammatory properties, which in theory are potentially beneficial in asthma. Many studies have shown that simvastatin has good therapeutic effect in animal models of asthma. However, the therapeutic effect and action mechanism of simvastatin for obese asthma remain unclear. Leptin, a satiety hormone, is in positive correlation with total body fat mass and may also play a significant role in the pathogenesis of asthma...
March 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28128443/potential-therapeutic-applications-of-adenosine-a2a-receptor-ligands-and-opportunities-for-a2a-receptor-imaging
#11
REVIEW
Aren van Waarde, Rudi A J O Dierckx, Xiaoyun Zhou, Shivashankar Khanapur, Hideo Tsukada, Kiichi Ishiwata, Gert Luurtsema, Erik F J de Vries, Philip H Elsinga
Adenosine A2A receptors (A2A Rs) are highly expressed in the human striatum, and at lower densities in the cerebral cortex, the hippocampus, and cells of the immune system. Antagonists of these receptors are potentially useful for the treatment of motor fluctuations, epilepsy, postischemic brain damage, or cognitive impairment, and for the control of an immune checkpoint during immunotherapy of cancer. A2A R agonists may suppress transplant rejection and graft-versus-host disease; be used to treat inflammatory disorders such as asthma, inflammatory bowel disease, and rheumatoid arthritis; be locally applied to promote wound healing and be employed in a strategy for transient opening of the blood-brain barrier (BBB) so that therapeutic drugs and monoclonal antibodies can enter the brain...
January 27, 2017: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28126313/the-influence-of-gender-and-atopy-in-the-relationship-between-obesity-and-asthma-in-childhood
#12
N Alvarez Zallo, I Aguinaga-Ontoso, I Alvarez-Alvarez, F Guillén-Grima, C Azcona San Julian
BACKGROUND: The objective of the study was to examine the relationship between asthma and overweight-obesity in Spanish children and adolescents and to determine whether this relationship was affected by gender and atopy. METHODS: The study involves 8607 Spanish children and adolescents from the International Study of Asthma and Allergies in Childhood phase III. Unconditional logistic regression was used to obtain adjusted odds ratios (OR) and 95% confidence intervals (95% CI) for the association between asthma symptoms and overweight-obesity in the two groups...
January 23, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28115224/the-burden-of-obesity-in-asthma-and-copd-role-of-adiponectin
#13
REVIEW
Andrea Bianco, Ersilia Nigro, Maria Ludovica Monaco, Maria Gabriella Matera, Olga Scudiero, Gennaro Mazzarella, Aurora Daniele
The influence of obesity on development, severity and prognosis of both asthma and COPD is attracting growing interest. The impact of obesity on the respiratory system ranges from structural modifications (decline of total lung capacity) to humoral alterations. Adipose tissue strongly contributes to the establishment of an inflammatory state being an important source of adipokines. Amongst adipokines, adiponectin is an important component of organ cross talk with adipose tissue exerting protective effects on a variety of pathophysiological processes...
January 20, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28111218/betanin-isolated-from-fruits-of-opuntia-elatior-mill-attenuates-renal-fibrosis-in-diabetic-rats-through-regulating-oxidative-stress-and-tgf-%C3%AE-pathway
#14
Brijesh Sutariya, Madhusudan Saraf
ETHNOPHARMACOLOGICAL RELEVANCE: The fruits of Opuntia elatior Mill are being used traditionally in different disease condition like diabetes, obesity, asthma, inflammatory disorders, and anemia. Betanin, a compound isolated from fruits of Opuntia elatior Mill has potent anti-oxidative and anti-inflammatory activity. Recent study from our lab indicated the protective effect of betanin against high glucose induced rat renal epithelial cell fibrosis and matrix accumulation, major features of diabetic nephropathy (DN)...
January 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28103443/effects-of-childhood-asthma-on-the-development-of-obesity-among-school-aged-children
#15
Zhanghua Chen, Muhammad T Salam, Tanya L Alderete, Rima Habre, Theresa M Bastain, Kiros Berhane, Frank D Gilliland
RATIONALE: Asthma and obesity often occur together in children. It is unknown whether asthma contributes to the childhood obesity epidemic. OBJECTIVES: We aimed to investigate the effects of asthma and asthma medication use on the development of childhood obesity. METHODS: The primary analysis was conducted among 2,171 non-obese children who were 5-8 years of age at study enrollment in the Southern California Children's Health Study (CHS) and were followed for up to 10 years...
January 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28093685/sleep-duration-obesity-and-asthma-in-florida-adolescents-analysis-of-data-from-the-florida-youth-risk-behavior-survey-2009-2013
#16
Chighaf Bakour, Kathleen O'Rourke, Skai Schwartz, Wei Wang, William Sappenfield, Marisa Couluris
PURPOSE: To examine the association between sleep duration and asthma among Florida high school students and whether body mass index (BMI) modifies this association. METHODS: This cross-sectional analysis included 16,728 participants in the Florida Youth Risk Behavior Survey (2009-2013). Using logistic regression, we examined the association between sleep duration and asthma, and, after controlling for potential confounders, analyzed the interaction between sleep duration and BMI...
January 16, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28087575/treating-inflammation-and-infection-in-the-21st-century-new-hints-from-decoding-resolution-mediators-and-mechanisms
#17
REVIEW
Charles N Serhan
Practitioners of ancient societies from the time of Hippocrates and earlier recognized and treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or inhibit proinflammatory chemical mediators. More selective drugs are available today, but this therapeutic concept has not changed. Because the acute inflammatory response is host protective to contain foreign invaders, much of today's pharmacopeia can cause serious unwanted side effects, such as immune suppression. Uncontrolled inflammation is now considered pathophysiologic and is associated with many widely occurring diseases such as cardiovascular disease, neurodegenerative diseases, diabetes, obesity, and asthma, as well as classic inflammatory diseases (e...
January 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28079560/prenatal-exposures-and-the-development-of-childhood-wheezing-illnesses
#18
Christian Rosas-Salazar, Tina V Hartert
PURPOSE OF REVIEW: To critically evaluate and summarize studies published between July 2015 and June 2016 linking prenatal exposures and the onset of childhood wheezing illnesses and to discuss future research directions in this field. RECENT FINDINGS: The aggregated evidence indicates a consistent detrimental effect of prenatal exposure to parental smoking, outdoor air pollution, and maternal stress on childhood wheezing illnesses. Less consistent evidence suggests an adverse impact of maternal obesity during pregnancy and prenatal exposure to antibiotics on these outcomes...
January 11, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28065772/multimorbidity-in-middle-aged-adults-with-cerebral-palsy
#19
Nicole Cremer, Edward A Hurvitz, Mark D Peterson
OBJECTIVE: Individuals with cerebral palsy have less lean body mass, greater relative adiposity, and lower fitness and physical activity participation, and yet the prevalence of age-related multimorbidity in this population has yet to be established. The study objective was to examine the prevalence of lifestyle-related chronic conditions and multimorbidity in a sample of middle-aged adults with cerebral palsy. METHODS: A clinic-based sample of middle-aged adults with cerebral palsy was examined using Electronic Medical Records Search Engine software...
January 5, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28053340/population-screening-and-treatment-of-helicobacter-pylori-infection
#20
REVIEW
Anthony O'Connor, Colm A O'Morain, Alexander C Ford
Helicobacter pylori is an important human pathogen, associated with a substantial burden from both malignant and non-malignant diseases. The bacterium is classed as a human carcinogen, being strongly linked with gastric cancer, the third most common cause of cancer death worldwide and is also associated with common conditions such as dyspepsia and peptic ulcer. Eradication of H. pylori reduces the incidence of gastric cancer and peptic ulcer, as well as the prevalence and costs of managing dyspepsia. Economic analyses suggest that eradication of H...
January 5, 2017: Nature Reviews. Gastroenterology & Hepatology
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