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Asthma obesity

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https://www.readbyqxmd.com/read/29048949/discovering-pediatric-asthma-phenotypes-based-on-response-to-controller-medication-using-machine-learning
#1
Mindy K Ross, Jinsung Yoon, Auke van der Schaar, Mihaela van der Schaar
RATIONALE: Pediatric asthma has variable underlying inflammation and symptom control. Approaches to address this heterogeneity such as clustering methods to find phenotypes and predicting outcomes have been investigated. However, clustering based upon the relationship between treatment and clinical outcome has not been performed. Also, machine learning approaches for long-term outcome prediction in pediatric asthma have not been studied in depth. OBJECTIVES: Our objectives were to use our novel machine learning algorithm, Predictor Pursuit (PP) to discover pediatric asthma phenotypes based on treatment response to different asthma controller medications, to predict outcomes of children with asthma over time, and to identify the most indicative features of asthma control for the discovered pediatric phenotypes...
October 19, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29048927/early-origins-of-asthma-role-of-microbial-dysbiosis-and-metabolic-dysfunction
#2
Fernando D Martinez, Stefano Guerra
Asthma is a developmental disease that affects airway growth and is characterized by inappropriate responses to a variety of environmental stimuli. Recent advances point to two altered early life pathways as major determinants of asthma risk. In the "microbial" pathway, pre- and post-natal exposures to microbiota-loaded farm environments block gene-virus interactions (e.g., interactions between risk alleles in chromosome 17q21 and lower respiratory illnesses [LRI] by rhinovirus) that are associated with asthma development...
October 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29044803/impact-of-pediatric-obesity-on-acute-asthma-exacerbation-in-japan
#3
Yusuke Okubo, Nobuaki Michihata, Koichi Yoshida, Naho Morisaki, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
BACKGROUND: Asthma and obesity are common health problems in children. This study investigated the impact of obesity on children hospitalized with acute asthma exacerbation. METHODS: We obtained the hospital discharge records of inpatients aged 3-8 years with a diagnosis of asthma using a national inpatient database in Japan. The patients were classified into underweight, normal weight, overweight, and obese groups using weight for height and body mass index for age provided by the World Health Organization...
October 18, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29021504/ethanol-extracts-of-aster-yomena-kitam-honda-inhibit-adipogenesis-through-the-activation-of-the-ampk-signaling-pathway-in-3t3-l1-preadipocytes
#4
Min Ho Han, Ji-Suk Jeong, Jin-Woo Jeong, Sung Hyun Choi, Sung Ok Kim, Su Hyun Hong, Cheol Park, Byung Woo Kim, Yung Hyun Choi
The leaves of Aster yomena (Kitam.) Honda have long been used as a traditional herb for treating disorders including coughs, asthma, and insect bites. According to recent studies, A. yomena leaf extracts have several pharmacological properties, including anti-inflammatory, antioxidant, and anti-asthmatic activities. However, little information is available regarding their anti-obesity effect. In this study, we investigated the inhibitory effect of the ethanol extracts of A. yomena leaves (EEAY) on adipocyte differentiation and adipogenesis using 3T3-L1 preadipocytes...
October 11, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29019632/racial-and-ethnic-health-disparities-and-trauma-informed-care-for-children-exposed-to-community-violence
#5
Bradley C Stolbach, Seeba Anam
Racial and ethnic disparities in health outcomes and access have been consistently documented for a wide variety of physical and behavioral health conditions. Health inequities are most pronounced in areas with high levels of racial and ethnic segregation, where children and adolescents are also more likely to face economic inequality, which places them at high risk for exposure to neighborhood violence and traumatic loss. Community violence exposure (CVE) has been increasingly recognized as a prominent contributor to negative physical and mental health outcomes...
October 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/29016794/epidemiology-of-chronic-respiratory-diseases-and-associated-factors-in-the-adult-italian-population
#6
Gianluigi Ferrante, Sandro Baldissera, Stefano Campostrini
Background: Detailed epidemiology of Chronic Respiratory Diseases (CRDs) and of their risk and protective factors is needed to plan preventive interventions to reduce the burden of CRDs on population health. This study determines the prevalence of doctor-diagnosed CRDs and its associated factors in the adult Italian population. Methods: Data was collected from adults participating in the ongoing cross-sectional Italian Behavioural Risk Factor Surveillance System (PASSI) between 2013 and 2015...
July 19, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28985770/systemic-inflammation-mediates-the-detrimental-effects-of-obesity-on-asthma-control
#7
X Zhang, J Zheng, L Zhang, Y Liu, G P Chen, H P Zhang, L Wang, D Y Kang, L G Wood, G Wang
BACKGROUND: Obesity negatively impacts asthma control, but the inflammatory mechanisms are poorly understood. OBJECTIVE: To explore which systemic inflammatory mediators mediate the effects of obesity on asthma control. METHODS: The subjects with stable asthma (n = 108) underwent assessment of clinical characteristics, which included usingThe Asthma Control Questionnaire (ACQ)-6. Obesity was defined as a body mass index (BMI) of more than or equal to 30 kg/m2, overweight was defined as BMI between 25 to 29...
October 2, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28983580/laparoscopic-sleeve-gastrectomy-for-morbidly-obese-adolescents-in-singapore
#8
Dallan Dargan, Dmitrii Dolgunov, Khin Thida Soe, Pamela Er, Fathimath Naseer, Davide Lomanto, Jimmy By So, Asim Shabbir
INTRODUCTION: Laparoscopic sleeve gastrectomy (LSG) outcomes among adolescents and adolescent obesity associated factors in Singapore were evaluated. METHODS: Prospectively collected data of patients aged 16-19 years at first presentation who underwent LSG was retrospectively reviewed. A questionnaire was completed incorporating cigarette, alcohol, dietary and exercise habits; family history of obesity; Berlin and Epworth scores; and Patient Health Questionnaire-9 (PHQ-9) scores...
October 6, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28983453/remote-sensing-between-liver-and-intestine-importance-of-microbial-metabolites
#9
Zidong Donna Fu, Julia Yue Cui
Recent technological advancements including metagenomics sequencing and metabolomics have allowed the discovery of critical functions of gut microbiota in obesity, malnutrition, neurological disorders, asthma, and xenobiotic metabolism. Classification of the human gut microbiome into distinct "enterotypes" has been proposed to serve as a new paradigm for understanding the interplay between microbial variation and human disease phenotypes, as many organs are affected by gut microbiota modifications during the pathogenesis of diseases...
June 2017: Current Pharmacology Reports
https://www.readbyqxmd.com/read/28983432/maternity-leave-policies-trade-offs-between-labour-market-demands-and-health-benefits-for-children
#10
Lucy Strang, Miriam Broeks
Over recent years many European Union countries have made changes to the design of the maternity leave provision. These policy developments reflect calls for greater gender equality in the workforce and more equal share of childcare responsibilities. However, while research shows that long period of leave can have negative effects on women's labour market attachment and career advancements, early return to work can be seen as a factor preventing exclusive breastfeeding, and therefore, potentially having negative health impacts for babies...
January 2017: Rand Health Quarterly
https://www.readbyqxmd.com/read/28967546/overweight-obesity-and-lung-function-in-children-and-adults-a-meta-analysis
#11
Erick Forno, Yueh-Ying Han, James Mullen, Juan C Celedón
BACKGROUND: There is conflicting evidence on the effect of obesity on lung function in adults and children with and without asthma. We aimed to evaluate the relation between overweight or obesity and lung function, and whether such relationship varies by age, sex, or asthma status. METHODS: We searched PubMed, Scopus, CINAHL, Cochrane, and EMBASE for all studies (in English) reporting on obesity status (by body mass index) and lung function, from 2005 to 2017. Main outcomes were forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC, forced expiratory flow between 25th and 75th percentile of the forced vital capacity (FEF25-75), total lung capacity (TLC), residual volume (RV), and functional residual capacity (FRC)...
September 26, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28965593/isoproterenol-exacerbates-hyperglycemia-and-modulates-chromium-distribution-in-mice-fed-with-a-high-fat-diet
#12
Geng-Ruei Chang, Wen-Kai Chen, Po-Hsun Hou, Frank Chiahung Mao
BACKGROUND AND PURPOSE: Isoproterenol (ISO), a nonselective β-adrenoceptor agonist for treating bradycardia and asthma, has been proposed to raise blood glucose level. Little is known regarding the relationship between ISO treatment, the induced chromium (Cr) redistribution, and changes in glucose metabolism. We aimed to characterize the effects of a single dose of ISO on glucose homeostasis and Cr level changes in an obesity mouse model. METHODS: Mice (C57BL6/j strain) were first fed for a continuous period of 12 weeks with either a high fat diet (HFD), to develop an obesity animal model, or a standard diet (SD), to develop a lean animal model as controls...
December 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28963295/associations-of-caesarean-delivery-and-the-occurrence-of-neurodevelopmental-disorders-asthma-or-obesity-in-childhood-based-on-taiwan-birth-cohort-study
#13
Ginden Chen, Wan-Lin Chiang, Bih-Ching Shu, Yue Leon Guo, Shu-Ti Chiou, Tung-Liang Chiang
OBJECTIVES: Whether birth by caesarean section (CS) increases the occurrence of neurodevelopmental disorders, asthma or obesity in childhood is controversial. We tried to demonstrate the association between children born by CS and the occurrence of the above three diseases at the age of 5.5 years. METHODS: The database of the Taiwan Birth Cohort Study which was designed to assess the developmental trajectories of 24 200 children born in 2005 was used in this study...
September 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28963089/residential-air-pollution-and-associations-with-wheeze-and-shortness-of-breath-in-adults-a-combined-analysis-of-cross-sectional-data-from-two-large-european-cohorts
#14
Dany Doiron, Kees de Hoogh, Nicole Probst-Hensch, Stéphane Mbatchou, Marloes Eeftens, Yutong Cai, Christian Schindler, Isabel Fortier, Susan Hodgson, Amadou Gaye, Ronald Stolk, Anna Hansell
BACKGROUND: Research examining associations between air pollution exposure and respiratory symptoms in adults has generally been inconclusive. This may be related in part to sample size issues, which also preclude analysis in potentially vulnerable subgroups. OBJECTIVES: We estimated associations between air pollution exposures and the prevalence of wheeze and shortness of breath using harmonized baseline data from two very large European cohorts, Lifelines (2006-2013) and UK Biobank (2006-2010)...
September 29, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28958273/variation-in-clinical-characteristics-of-women-versus-men-preoperative-for-laparoscopic-roux-en-y-gastric-bypass-analysis-of-83-059-patients
#15
COMPARATIVE STUDY
Jandie Schwartz, Christopher Bashian, Leon Kushnir, Cristina Nituica, Gus J Slotman
Variation by sex in preoperative clinical characteristics of female and male laparoscopic Roux-en-Y gastric bypass (LRYGB) patients has not been evaluated comprehensively. The objective of our study was to identify clinical differences between morbidly obese women and men seeking LRYGB. Data from 83,059 patients in the Surgical Review Corporation's Bariatric Outcomes Longitudinal Database who were about to undergo LRYGB was analyzed in two groups: women (n = 65,325) and men (n = 17,734). Statistics were evaluated with analysis of variance and the χ2 equation...
September 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28952460/serum-and-exhaled-breath-condensate-leptin-levels-in-asthmatic-and-obesity-children-a-pilot-study
#16
A Bodini, L Tenero, M Sandri, C Maffeis, M Piazza, L Zanoni, D Peroni, A Boner, G Piacentini
BACKGROUND: Recent studies have highlighted the possible involvement of leptin in inflammation. The leptin receptor is also expressed by alveolar macrophages, T lymphocytes and bronchial epitelial cells, suggesting a possible role in the cascade of airway inflammation. OBJECTIVES: The aim of the study was to evaluate the levels of leptin in exhaled breath condensate (EBC) from asthmatic, normal- and overweight children, in relationship with airway inflammation. METHODS: 15 asthmatic non-obese children, 15 healthy non-asthmatic non-obese children, 11 obese children with asthma (OA) and 20 obese children without asthma (ONA) were enrolled...
September 27, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28950722/the-cdc-foundation-s-health-and-well-being-for-all-meeting-in-a-box
#17
Sarah E Pember
The conditions in which people live, work, play, and age-the social determinants of health (SDOH)-have an impact on their health outcomes and behavior, sense of security, and patterns of community engagement. To encourage training and education related to the health effects of the SDOH, the Centers for Disease Control and Prevention Foundation created the Health and Well-Being for All meeting-in-a-box resource. This online resource acts as a guide for group collaboration and education related to understanding SDOH effects on health and practicing methods for addressing those effects at the community level, and can be used with a variety of groups, including community coalitions, health education students, and medical professionals...
September 1, 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28944123/preventing-cushing-iatrogenic-cushing-syndrome-due-to-ritonavir-fluticasone-interaction
#18
Fasil Tiruneh, Ahmad Awan, Abiot Didana, Saumil Doshi
Ritonavir is commonly used in low doses to boost plasma levels of protease inhibitors in patients with human immunodeficiency virus (HIV) infections. It is also a potent inhibitor of cytochrome P450. We present a 50-year-old African American male with past medical history of HIV on highly active antiretroviral therapy (HAART), which also included ritonavir and long standing asthma that has been treated with inhaled fluticasone, who presented with back pain. He had central obesity, prominent abdominal striae and wasted extremities on physical examination...
July 17, 2017: Curēus
https://www.readbyqxmd.com/read/28929093/the-elevated-rate-of-cesarean-section-and-its-contribution-to-non-communicable-chronic-diseases-in-latin-america-the-growing-involvement-of-the-microbiota
#19
REVIEW
Fabien Magne, Alexa Puchi Silva, Bielka Carvajal, Martin Gotteland
The current recommendation of the World Health Organization (WHO) regarding cesarean section (C-section) is that this clinical practice should be carried out only under specific conditions, when the health or life of the mother/newborn dyad is threatened, and that its use should not exceed 10-15% of the total deliveries. However, over the last few decades, the frequency of C-section delivery in medium- and high-income countries has rapidly increased worldwide. This review describes the evolution of this procedure in Latin American countries, showing that today more than half of newborns in the region are delivered by C-section...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28925418/mhealth-application-areas-and-technology-combinations-a-comparison-of-literature-from-high-and-low-middle-income-countries
#20
Haitham Abaza, Michael Marschollek
BACKGROUND: With the continuous and enormous spread of mobile technologies, mHealth has evolved as a new subfield of eHealth. While eHealth is broadly focused on information and communication technologies, mHealth seeks to explore more into mobile devices and wireless communication. Since mobile phone penetration has exceeded other infrastructure in low and middle-income countries (LMICs), mHealth is seen as a promising component to provide pervasive and patient-centered care. OBJECTIVES: The aim of our research work for this paper is to examine the mHealth literature to identify application areas, target diseases, and mHealth service and technology types that are most appropriate for LMICs...
August 8, 2017: Methods of Information in Medicine
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