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Asthma obesity

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https://www.readbyqxmd.com/read/28727539/state-and-local-chronic-disease-surveillance-using-electronic-health-record-systems
#1
Michael Klompas, Noelle M Cocoros, John T Menchaca, Diana Erani, Ellen Hafer, Brian Herrick, Mark Josephson, Michael Lee, Michelle D Payne Weiss, Bob Zambarano, Karen R Eberhardt, Jessica Malenfant, Laura Nasuti, Thomas Land
OBJECTIVES: To assess the feasibility of chronic disease surveillance using distributed analysis of electronic health records and to compare results with Behavioral Risk Factor Surveillance System (BRFSS) state and small-area estimates. METHODS: We queried the electronic health records of 3 independent Massachusetts-based practice groups using a distributed analysis tool called MDPHnet to measure the prevalence of diabetes, asthma, smoking, hypertension, and obesity in adults for the state and 13 cities...
July 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28696535/bmi-predicts-exercise-induced-bronchoconstriction-in-asthmatic-boys
#2
Wilma J van Veen, Jean M M Driessen, Elin T G Kersten, Janneke C van Leeuwen, Marjolein G J Brusse-Keizer, Wim M C van Aalderen, Bernard J Thio
BACKGROUND: Exercise induced bronchoconstriction (EIB) is a frustrating morbidity of asthma in children. Obesity has been associated with asthma and with more severe EIB in asthmatic children. OBJECTIVES: To quantify the effect of BMI on the risk of the occurrence of EIB in children with asthma. METHODS: Data were collected from six studies in which exercise challenge tests were performed according to international guidelines. We included 212 Children aged 7-18 years, with a pediatrician-diagnosed mild-to-moderate asthma...
July 11, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28696379/obesity-and-asthma-a-missing-link
#3
REVIEW
Mª Amelia Gomez-Llorente, Raquel Romero, Natalia Chueca, Ana Martinez-Cañavate, Carolina Gomez-Llorente
Obesity and asthma are two chronic conditions that affect millions of people. Genetic and lifestyle factors such as diet, physical activity, and early exposure to micro-organisms are important factors that may contribute to the escalating prevalence of both conditions. The prevalence of asthma is higher in obese individuals. Recently, two major phenotypes of asthma with obesity have been described: one phenotype of early-onset asthma that is aggravated by obesity, and a second phenotype of later-onset asthma that predominantly affects women...
July 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28692781/depression-as-a-risk-factor-of-organic-diseases-an-international-integrative-review
#4
Teodora Bica, Ruth Castelló, Loren L Toussaint, Pilar Montesó-Curto
PURPOSE AND DESIGN: This integrative review offers a systematic synthesis of the international literature regarding the role of depression as a risk factor in physical illnesses and the mechanisms of this connection. Special attention is paid to those modifiable factors. FINDINGS: Published studies of depression and physical illness and disease(N = 24) from five countries that were indexed in PubMed, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), APA PsycNET, Scopus, Dialnet, and CUIDEN were examined...
July 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28684597/dynamic-hyperinflation-and-exercise-limitations-in-obese-asthmatic-women
#5
Palmira Gabriele Ferreira, Patricia Duarte Freitas, Aline Grandi Silva, Desiderio Cano Porras, Rafael Stelmach, Alberto Cukier, Frederico Leon Arrabal Fernandes, Mílton A Martins, Celso R F Carvalho
Obese individuals and patients with asthma can develop dynamic hyperinflation (DH) during exercise; however, no previous study has investigated DH as a factor associated with reduced exercise capacity in obese asthmatic women. The aim of the present study was to examine the occurrence of DH and exercise limitations in obese asthmatics. Obese grade II (obese group (Ob-G); BMI 35-39.9 kg/m2; n=36) and non-obese (non-obese group (NOb-G); BMI 18.5-29.9 kg/m2; n=18) asthmatic patients performed a cardiopulmonary test to quantify peak VO2 and a submaximal exercise test to assess DH...
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28680543/a-population-based-cohort-of-adults-with-asthma-mortality-and-participation-in-a-long-term-follow-up
#6
Helena Backman, Linnea Hedman, Caroline Stridsman, Sven-Arne Jansson, Anne Lindberg, Bo Lundbäck, Eva Rönmark
Background and objective: Asthma is a major public health concern. The aim of this study was to characterize a large population-based cohort of adults with asthma, and to study factors associated with all-cause mortality and non-participation in a long-term follow-up. Design: Random and stratified samples from five population-based cohorts were clinically examined during 1986-2001, and all subjects with asthma were included in the study (n = 2055, age 19-72 years, 55% women). Independent associations between different risk factors and (i) mortality and (ii) non-participation in a clinical follow-up in 2012-2014 were estimated...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28673295/the-impact-of-racial-discrimination-on-the-health-of-australian-indigenous-children-aged-5-10%C3%A2-years-analysis-of-national-longitudinal-data
#7
Carrington C J Shepherd, Jianghong Li, Matthew N Cooper, Katrina D Hopkins, Brad M Farrant
BACKGROUND: A growing body of literature highlights that racial discrimination has negative impacts on child health, although most studies have been limited to an examination of direct forms of racism using cross-sectional data. We aim to provide further insights on the impact of early exposure to racism on child health using longitudinal data among Indigenous children in Australia and multiple indicators of racial discrimination. METHODS: We used data on 1239 Indigenous children aged 5-10 years from Waves 1-6 (2008-2013) of Footprints in Time, a longitudinal study of Indigenous children across Australia...
July 3, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28671393/top-20-research-studies-of-2016-for-primary-care-physicians
#8
Mark H Ebell, Roland Grad
This article summarizes the top 20 original research studies and four practice guidelines of 2016, based on regular literature surveillance and as selected by members of the Canadian Medical Association. The studies, known as POEMs (patient-oriented evidence that matters), were rated highly because of their relevance, validity, and potential to change practice. Key hypertension treatment findings include reduced mortality (a benefit not demonstrated in lower-risk persons or persons with diabetes mellitus) but also an increase in harms with a more aggressive blood pressure target in high-risk persons with hypertension and without diabetes...
May 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28670116/treatment-trends-in-patients-with-asthma-copd-overlap-syndrome-in-a-copd-cohort-findings-from-a-real-world-survey
#9
Bo Ding, Mark Small
BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is an increasingly recognized phenotype. Few randomized clinical trials have been conducted in patients with ACOS; therefore, scientific evidence concerning ACOS is scarce and a therapeutic approach remains unclear. The aim of this study was to evaluate current treatment trends for patients with ACOS, identified as those with a dual definition of asthma and COPD, in a real-world COPD cohort. METHODS: Data were analyzed from patients with asthma and COPD in the USA, France, Germany, Italy, Spain, and the UK who participated in the 2012 and 2013 Adelphi Respiratory Disease Specific Programmes (DSPs)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28668238/genetic-variants-and-risk-of-asthma-in-an-american-indian-population
#10
Lyle G Best, Crystal Azure, Alexandre Segarra, Kendra J Enright, Shawn Hamley, Dara Jerome, Marcia A O'Leary, Rae A O'Leary, Ashley Parisien, Kayana Trottier, Joseph M Yracheta, Dara G Torgerson
BACKGROUND: Asthma is recognized as a complex, multifactorial disease with a genetic component that is well recognized. Certain genetic variants are associated with asthma in a number of populations. OBJECTIVE: To determine whether the same variants increase the risk of asthma among American Indian children. METHODS: The electronic medical records of an Indian Health Service facility identified all children between 6 and 17 years of age with case-defining criteria for asthma (n = 108)...
July 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28668107/asthma-in-older-people-hospitalized-with-influenza-in-spain-a-case-control-study
#11
María Morales-Suárez-Varela, Agustín Llopis-González, Carlos Vergara-Hernández, Estrella Fernandez-Fabrellas, Francisco Sanz, María José Perez-Lozano, Vicente Martin, Jenaro Astray, Jesús Castilla, Mikel Egurrola, Luis Force, Diana Toledo, Àngela Domínguez
BACKGROUND: Influenza infection is an exacerbating factor for asthma, and its prevention is critical in older patients with asthma. OBJECTIVE: This study investigated the association between asthma and influenza-related hospitalization, in Spain, of patients ages ≥ 65 years and their clinical evolution. METHODS: A multicenter case-control study was carried out in 20 Spanish hospitals during the 2013-2014 and 2014-2015 influenza seasons. Patients ages ≥ 65 years hospitalized with laboratory-confirmed influenza with and without asthma were matched with controls according to the presence of asthma, sex, age, hospital, and date of hospitalization...
July 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28661182/prenatal-nitrate-exposure-and-childhood-asthma-influence-of-maternal-prenatal-stress-and-fetal-sex
#12
Sonali Bose, Yueh-Hsiu M Chiu, Hsiao-Hsien L Hsu, Qian Di, Maria José Rosa, Alison Lee, Itai Kloog, Ander Wilson, Joel Schwartz, Robert O Wright, Sheldon Cohen, Brent A Coull, Rosalind J Wright
RATIONALE: Impact of ambient pollution upon children's asthma may differ by sex, and exposure dose and timing. Psychosocial stress can also modify pollutant effects. These associations have not been examined for in utero ambient nitrate exposure. OBJECTIVES: We implemented Bayesian distributed lag interaction models (BDLIMs), to identify sensitive prenatal windows for the influence of NO3- on child asthma, accounting for effect modification by sex and stress. METHODS: Analyses included 752 mother-child dyads...
June 29, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28659218/effect-of-dietary-consumption-as-a-modifier-on-the-association-between-fto-gene-variants-and-excess-body-weight-in-children-from-an-admixed-population-in-brazil-the-social-changes-asthma-and-allergy-in-latin-america-scaala-cohort-study
#13
Marília Vilella, Gustavo Nunes de Oliveira Costa, Maurício Lima Barreto, Camila Alexandrina Figueredo, Neuza Maria Alcantara-Neves, Laura Cunha Rodrigues, Sheila Maria Alvim de Matos, Rosemeire Leovigildo Fiaccone, Pablo Oliveira, Aline Rocha, Rita de Cássia Ribeiro-Silva
Previous studies have shown associations of variants of the FTO gene with body weight, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the north-eastern Brazilian population. This study evaluated the association between SNP in the FTO gene and excess weight in Salvador, Bahia, Brazil. In addition, the effect of diet as a modifier on this association was also investigated. This cross-sectional study included 1191 participants aged 4-11 years, who were genotyped for 400 variants of the FTO gene...
June 29, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28658728/-mediators-of-inflammatory-response-in-asthma-and-its-association-with-obesity
#14
Gustavo Galicia-Negrete, Ramcés Falfán-Valencia
There is an increase in the prevalence of asthma and obesity, constituting a public health problem at national and global levels. The association between the two pathologies has not been clearly determined; however, a certain synergy has been proposed, which leads to more severe bronchospasms, longer recovery time, and more prolonged use of medications in obese asthmatic patients. The discovery of leptin, an adipokine that is directly related to the amount of total body fat and the production of proinflammatory cytokines, has generated greater interest in white adipose tissue...
April 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/28658552/mechanisms-and-treatments-for-severe-steroid-resistant-allergic-airway-disease-and-asthma
#15
REVIEW
Philip M Hansbro, Richard Y Kim, Malcolm R Starkey, Chantal Donovan, Kamal Dua, Jemma R Mayall, Gang Liu, Nicole G Hansbro, Jodie L Simpson, Lisa G Wood, Jeremy A Hirota, Darryl A Knight, Paul S Foster, Jay C Horvat
Severe, steroid-resistant asthma is clinically and economically important since affected individuals do not respond to mainstay corticosteroid treatments for asthma. Patients with this disease experience more frequent exacerbations of asthma, are more likely to be hospitalized, and have a poorer quality of life. Effective therapies are urgently required, however, their development has been hampered by a lack of understanding of the pathological processes that underpin disease. A major obstacle to understanding the processes that drive severe, steroid-resistant asthma is that the several endotypes of the disease have been described that are characterized by different inflammatory and immunological phenotypes...
July 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28657361/sleep-deprivation-and-chronic-health-conditions-among-sexual-minority-adults
#16
Hongying Dai, Jianqiang Hao
Objectives - To examine associations between sleep duration and health outcomes among distinct groups of sexual minority adults. Methods - Using data from the 2014 Behavioral Risk Factor Surveillance System, we compared sleep duration (very short: ≤5 hours, short: 6 hours, normal: 7-8 hours, and long: ≥9 hours per day) between cisgender straight adults and distinct groups of sexual minorities. We further examined associations between sleep duration and 10 chronic health conditions among sexual minorities...
June 28, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28651434/body-mass-index-and-functional-impairment-the-explanatory-role-of-anxiety-sensitivity-among-treatment-seeking-smokers
#17
Brooke Y Kauffman, Lorra Garey, Charles Jardin, Michael W Otto, Amanda M Raines, Norman B Schmidt, Michael J Zvolensky
Obesity and smoking are highly prevalent public health concerns in the United States. Data indicate that elevated Body Mass Index (BMI) is related to functional impairment. However, there is limited understanding of mechanisms that may explain their comorbidity among smokers. The current study sought to test whether anxiety sensitivity explained the relation between BMI and functional impairment among 420 (46.9% females; Mage = 38 years, SD = 13.42) treatment-seeking, adult smokers. Results indicated that BMI yielded a significant indirect effect through anxiety sensitivity for functional impairment, b = 0...
June 27, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28648831/glucagon-like-peptide-1-a-potential-anti-inflammatory-pathway-in-obesity-related-asthma
#18
REVIEW
Dan-Vinh Nguyen, Angela Linderholm, Angela Haczku, Nicholas Kenyon
Alterations in arginine metabolism and accelerated formation of advanced glycation end-products (AGEs), crucial mechanisms in obesity-related asthma, can be modulated by glucagon-like peptide 1 (GLP-1). l-arginine dysregulation in obesity promotes inflammation and bronchoconstriction. Prolonged hyperglycemia, dyslipidemia, and oxidative stress leads to production of AGEs, that bind to their receptor (RAGE) further potentiating inflammation. By binding to its widely distributed receptor, GLP-1 blunts the effects of RAGE activation and arginine dysregulation...
June 22, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28647509/a-review-of-acalypha-indica-l-euphorbiaceae-as-traditional-medicinal-plant-and-its-therapeutic-potential
#19
REVIEW
Nor Syahiran Zahidin, Syafiqah Saidin, Razauden Mohamed Zulkifli, Ida Idayu Muhamad, Harisun Ya'akob, Hadi Nur
ETHNOPHARMACOLOGICAL RELEVANCE: Acalypha indica is an herbal plant that grows in wet, temperate and tropical region, primarily along the earth's equator line. This plant is considered by most people as a weed and can easily be found in these regions. Although this plant is a weed, Acalypha indica has been acknowledged by local people as a useful source of medicine for several therapeutic treatments. They consume parts of the plant for many therapeutics purposes such as anthelmintic, anti-ulcer, bronchitis, asthma, wound healing, anti-bacterial and other applications...
June 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28645880/biomarkers-of-airway-and-systemic-inflammation-in-obese-asthmatic-paediatric-patients
#20
H T Nacaroglu, O B Gayret, M Erol, O Buke, O Zengi, M Tasdemir, Z Tasdemir, O Yigit
BACKGROUND: It is thought that airway inflammation is more common in obese asthmatic patients because inflammation is harder to control and does not respond well to glucocorticoid treatment. OBJECTIVE: This study's aim was to investigate the effect of obesity on airway and systemic inflammation in children with asthma and to identify the biomarkers that play a role in this inflammation. METHODS: The study included patients aged 6-16 years who were diagnosed with asthma in the paediatric allergy outpatient clinic of Bagcilar Training and Research Hospital in Turkey...
June 20, 2017: Allergologia et Immunopathologia
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