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Organic synthesis

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https://www.readbyqxmd.com/read/28214219/perpetuating-stigma-or-reducing-risk-perspectives-from-naloxone-consumers-and-pharmacists-on-pharmacy-based-naloxone-in-2-states
#1
Traci C Green, Patricia Case, Haley Fiske, Janette Baird, Shachan Cabral, Dina Burstein, Victoriana Schwartz, Nathan Potter, Alexander Y Walley, Jeffrey Bratberg
OBJECTIVES: Little is known about attitudes of pharmacists and consumers to pharmacy naloxone. We examined perceptions and experiences of pharmacy naloxone from people with opioid use disorder, patients taking chronic opioids for pain, caregivers of opioid users, and pharmacists from 2 early pharmacy naloxone adopter states: Massachusetts and Rhode Island. DESIGN: Eight focus groups (4 per state) were held in October to December 2015. SETTING AND PARTICIPANTS: Participants were recruited from pharmacies, health clinics, and community organizations; pharmacists were recruited from professional organizations and pharmacy colleges...
February 14, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28213771/a-novel-spiroindoline-targets-cell-cycle-and-migration-via-modulation-of-microtubule-cytoskeleton
#2
Naveen Kumar, Santanu Hati, Parthapratim Munshi, Subhabrata Sen, Seema Sehrawat, Shailja Singh
Natural product-inspired libraries of molecules with diverse architectures have evolved as one of the most useful tools for discovering lead molecules for drug discovery. In comparison to conventional combinatorial libraries, these molecules have been inferred to perform better in phenotypic screening against complicated targets. Diversity-oriented synthesis (DOS) is a forward directional strategy to access such multifaceted library of molecules. From a successful DOS campaign of a natural product-inspired library, recently a small molecule with spiroindoline motif was identified as a potent anti-breast cancer compound...
February 17, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28213298/electroplating-sludge-derived-zinc-ferrite-catalyst-for-the-efficient-photo-fenton-degradation-of-dye
#3
Zhenbang Cao, Jia Zhang, Jizhi Zhou, Xiuxiu Ruan, Dan Chen, Jianyong Liu, Qiang Liu, Guangren Qian
A zinc-dominant ferrite catalyst for efficient degradation of organic dye was prepared by the calcination of electroplating sludge (ES). Characterizations indicated that zinc ferrite (ZnFe2O4) coexisted with Fe2O3 structure was the predominant phase in the calcined electroplating sludge (CES). CES displayed a high decolorization ratio (88.3%) of methylene blue (MB) in the presence of H2O2 combined with UV irradiation. The high efficiency could be ascribed to the photocatalytic process induced by ZnFe2O4 and the photo-Fenton dye degradation by ferrous content, and a small amount of Al and Mg in the sludge might also contribute to the catalysis...
February 14, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28213284/synthesis-of-hetero-annulated-isoxazolo-pyrido-and-pyrimido-carbazoles-screened-for-in%C3%A2-vitro-antitumor-activity-and-structure-activity-relationships-a-novel-2-amino-4-3-bromo-4-methoxyphenyl-8-chloro-11h-pyrimido-4-5-a-carbazole-as-an-antitumor-agent
#4
Karunanidhi Murali, Hazel A Sparkes, Karnam Jayarampillai Rajendra Prasad
Claisen-Schmidt condensation of 2,3,4,9-tetrahydro-1H-carbazol-1-one with 3-bromo-4-methoxy benzaldehyde afforded the 2-(3'-bromo-4'-methoxybenzylidene)-2,3,4,9-tetrahydro-1H-carbazol-1-one 3. Compound 3 was allowed to react with different organic reactants, hydroxylamine hydrochloride, malononitrile and guanidine nitrate through condensation cum cycloaddition reactions to afford a series of the respective novel hetero annulated carbazoles such as isoxazolo-, pyrido- and pyrimido carbazoles. The structures of the compounds were established by FT-IR, (1)H NMR, (13)C NMR, X-ray diffraction and elemental analysis...
February 7, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28213107/hypoglycemic-effect-of-the-polyphenols-rich-extract-from-rose-rugosa-thunb-on-high-fat-diet-and-stz-induced-diabetic-rats
#5
Liu Liu, Dan Tang, Haiqing Zhao, Xuelei Xin, Haji Akber Aisa
ETHNOPHARMACOLOGICAL RELEVANCE: Rosa rugosa Thunb is traditional Uygur medicine, it is widely used for regulating blood condition, nourishing liver and gallbladder in Uygur ancient prescription. But the mechanism of Rosa rugosa Thunb on diabetes is still unclear. In here, we studied the hypoglycemic effect and explained one probable pathway of polyphenols rich extract from Rosa rugosa Thunb (RPE) on diabetic rats. MATERIALS AND METHODS: In vitro, the effect of RPE on α-glucosidase inhibition was finished, and the antioxidant activity of RPE was evaluated by ABTS and DPPH assay...
February 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28212677/fit-for-purpose-perspectives-on-rapid-reviews-from-end-user-interviews
#6
Lisa Hartling, Jeanne-Marie Guise, Susanne Hempel, Robin Featherstone, Matthew D Mitchell, Makalapua L Motu'apuaka, Karen A Robinson, Karen Schoelles, Annette Totten, Evelyn Whitlock, Timothy J Wilt, Johanna Anderson, Elise Berliner, Aysegul Gozu, Elisabeth Kato, Robin Paynter, Craig A Umscheid
BACKGROUND: There is increasing demand for rapid reviews and timely evidence synthesis. The goal of this project was to understand end-user perspectives on the utility and limitations of rapid products including evidence inventories, rapid responses, and rapid reviews. METHODS: Interviews were conducted with key informants representing: guideline developers (n = 3), health care providers/health system organizations (n = 3), research funders (n = 1), and payers/health insurers (n = 1)...
February 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28212485/efficient-upconverting-multiferroic-core-shell-photocatalysts-visible-to-near-infrared-photon-harvesting
#7
Jianming Zhang, Yue Huang, Lei Jin, Federico Rosei, Fiorenzo Vetrone, Jerome P Claverie
We report the two-step synthesis of a core@shell nanohybrid material for visible-to-near-infrared (NIR) photocatalysis. The core is constituted of NaGdF4:Er(3+), Yb(3+) upconverting nanoparticles (UCNPs). A bismuth ferrite (BFO) shell is assembled around the UCNPs via a hydrothermal process. The photocatalytic degradation assays of organic compounds of methylene orange and 4-chlorophenol reveal that core@shell nanostructures possess remarkably enhanced reaction activity under visible and NIR irradiation, compared to the BFO powder alone and the BFO-UCNP mixture...
February 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28212382/de-novo-assembly-of-the-sea-trout-salmo-trutta-m-trutta-skin-transcriptome-to-identify-putative-genes-involved-in-the-immune-response-and-epidermal-mucus-secretion
#8
Magdalena Malachowicz, Roman Wenne, Artur Burzynski
In fish, the skin is a multifunctional organ and the first barrier against pathogens. Salmonids differ in their susceptibility to microorganisms due to varied skin morphology and gene expression patterns. The brown trout is a salmonid species with important commercial and ecological value in Europe. However, there is a lack of knowledge regarding the genes involved in the immune response and mucus secretion in the skin of this fish. Thus, we characterized the skin transcriptome of anadromous brown trout using next-generation sequencing (NGS)...
2017: PloS One
https://www.readbyqxmd.com/read/28211620/benchmark-ditopic-binding-of-cl-and-cs-by-the-macrocycle-hexacyclen
#9
Juan Ramon Aviles-Moreno, Giel Berden, Jos Oomens, Bruno Martinez-Haya
The ditopic binding of organic and inorganic anions and cations constitutes a distinct feature of polyazamacrocycles that underlies their action as intermediate docking and exchange ionophoric sites for tailored supramolecular synthesis and sensors. This work investigates the Cl- and Cs+ complexes formed by hexacyclen (1,4,7,10,13,16-hexaazacyclooctadecane, ha18c6), a benchmark building block of ion-pair polyamine receptors. Infrared action spectroscopy is employed to characterize the anionic and cationic complexes under controlled environmental conditions in an ion trap...
February 17, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28211512/physiology-and-role-of-irisin-in-glucose-homeostasis
#10
REVIEW
Nikolaos Perakakis, Georgios A Triantafyllou, José Manuel Fernández-Real, Joo Young Huh, Kyung Hee Park, Jochen Seufert, Christos S Mantzoros
Irisin is a myokine that leads to increased energy expenditure by stimulating the 'browning' of white adipose tissue. In the first description of this hormone, increased levels of circulating irisin, which is cleaved from its precursor fibronectin type III domain-containing protein 5, were associated with improved glucose homeostasis by reducing insulin resistance. Consequently, several studies attempted to characterize the role of irisin in glucose regulation, but contradictory results have been reported, and even the existence of this hormone has been questioned...
February 17, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28211209/synthesis-and-reduction-of-uranium-v-imido-complexes-with-redox-active-substituents
#11
Kimberly C Mullane, Patrick J Carroll, Eric J Schelter
Organic azides containing naphthyl functionalities were used to prepare uranium(V) imido complexes UV[=NC(2-naph)Ph2][N(SiMe3)2]3 (2), UV[=NC(2-naph)3][N(SiMe3)2]3 (3), and UV[=N(2-naph)][N(SiMe3)2]3 (4), and compared with UV[=NCPh3][N(SiMe3)2]3 (1). The electronic structures of these compounds were investigated by solution electrochemistry studies that revealed accessible U(V/VI), U(IV/V), and naphthalene0/naphthalene-1 couples. The uranium(V) naphthyl-imido complexes were reduced by potassium graphite to yield their uranium(IV) congeners K[UIV[=NC(2-naph)Ph2][N(SiMe3)2]3] (2-K), K[UIV[=NC(2-naph)3][N(SiMe3)2]3] (3-K), and K[UIV[=N(2-naph)][N(SiMe3)2]3] (4-K)...
February 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28211171/applications-of-the-wittig-still-rearrangement-in-organic-synthesis
#12
Lukas Rycek, Tomas Hudlicky
This review traces the discovery of the Wittig-Still rearrangement and its applications in organic synthesis. Its relationship to Wittig rearrangements is discussed along with detailed analysis of E/Z- and diastereoselectivity. Modifications of the products arising from the Wittig-Still rearrangement are reviewed in the context of increased complexity in intermediates potentially useful in target oriented synthesis. Early applications of the Wittig-Still rearrangement to modifications of steroids are reviewed as are applications to various terpene and alkaloid natural product targets and miscellaneous compounds...
February 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28211142/a-stable-hexakis-guanidino-benzene-realization-of-the-strongest-neutral-organic-four-electron-donor
#13
Benjamin Eberle, Elisabeth Kaifer, Hans-Jörg Himmel
The growing demand for efficient batteries has stimulated the search for redox-active organic compounds with multistage redox behavior, as materials with large charge capacity. Herein we report the synthesis and properties of the first hexakis(guanidino)benzene derivative: a strong neutral organic electron donor with reversible multistage redox behavior and a record low redox potential for donation of four electrons. Detailed structural and spectroscopic characterization of three redox states (0, +2, and +4) reveal its unique electronic features...
February 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28211118/transcriptional-and-cell-cycle-alterations-mark-aging-of-primary-human-adipose-derived-stem-cells
#14
Xiaoyin Shan, Cleresa Roberts, Eun Ji Kim, Ariana Brenner, Gregory Grant, Ivona Percec
Adult stem cells play a critical role in the maintenance of tissue homeostasis and prevention of aging. While the regenerative potential of stem cells with low cellular turnover, such as adipose-derived stem cells (ASC), is increasingly recognized, the study of chronological aging in ASCs is technically difficult, and remains poorly understood. Here, we employ our model of chronological aging in primary human ASCs to examine genome-wide transcriptional networks. We demonstrate first that the transcriptome of aging ASCs is distinctly more stable than that of age-matched fibroblasts, and further, that age-dependent modifications in cell cycle progression and translation initiation specifically characterize aging ASCs in conjunction with increased nascent protein synthesis and a distinctly shortened G1 phase...
February 17, 2017: Stem Cells
https://www.readbyqxmd.com/read/28211005/resequencing-and-annotation-of-the-nostoc-punctiforme-attc-29133-genome-facilitating-biofuel-and-high-value-chemical-production
#15
Luis E Moraes, Matthew J Blow, Erik R Hawley, Hailan Piao, Rita Kuo, Jennifer Chiniquy, Nicole Shapiro, Tanja Woyke, James G Fadel, Matthias Hess
Cyanobacteria have the potential to produce bulk and fine chemicals and members belonging to Nostoc sp. have received particular attention due to their relatively fast growth rate and the relative ease with which they can be harvested. Nostoc punctiforme is an aerobic, motile, Gram-negative, filamentous cyanobacterium that has been studied intensively to enhance our understanding of microbial carbon and nitrogen fixation. The genome of the type strain N. punctiforme ATCC 29133 was sequenced in 2001 and the scientific community has used these genome data extensively since then...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28209899/gtpase-activity-coupled-treadmilling-of-the-bacterial-tubulin-ftsz-organizes-septal-cell-wall-synthesis
#16
Xinxing Yang, Zhixin Lyu, Amanda Miguel, Ryan McQuillen, Kerwyn Casey Huang, Jie Xiao
The bacterial tubulin FtsZ is the central component of the cell division machinery, coordinating an ensemble of proteins involved in septal cell wall synthesis to ensure successful constriction. How cells achieve this coordination is unknown. We found that in Escherichia coli cells, FtsZ exhibits dynamic treadmilling predominantly determined by its guanosine triphosphatase activity. The treadmilling dynamics direct the processive movement of the septal cell wall synthesis machinery but do not limit the rate of septal synthesis...
February 17, 2017: Science
https://www.readbyqxmd.com/read/28209894/catalytic-intermolecular-hydroaminations-of-unactivated-olefins-with-secondary-alkyl-amines
#17
Andrew J Musacchio, Brendan C Lainhart, Xin Zhang, Saeed G Naguib, Trevor C Sherwood, Robert R Knowles
The intermolecular hydroamination of unactivated alkenes with simple dialkyl amines remains an unsolved problem in organic synthesis. We report a catalytic protocol for efficient additions of cyclic and acyclic secondary alkyl amines to a wide range of alkyl olefins with complete anti-Markovnikov regioselectivity. In this process, carbon-nitrogen bond formation proceeds through a key aminium radical cation intermediate that is generated via electron transfer between an excited-state iridium photocatalyst and an amine substrate...
February 17, 2017: Science
https://www.readbyqxmd.com/read/28209601/the-influence-of-rosuvastatin-upon-the-gastrointestinal-microbiota-and-host-gene-expression-profiles
#18
James A Nolan, Peter Henry Skuse, Kalaimathi Govindarajan, Elaine Patterson, Nina Konstantinidou, Patrick G Casey, John MacSharry, Fergus Shanahan, Catherine Stanton, Colin Hill, P D Cotter, Susan A Joyce, Cormac Gm Gahan
Statins are the most widely prescribed medications worldwide for the treatment of hypercholesterolemia. They inhibit the activity of 3-hydroxy-3-methylglutaryl co enzyme A reductase (HMG-R) an enzyme involved in cholesterol synthesis in higher organisms and in isoprenoid biosynthesis in some bacteria. We hypothesized that statins may influence the microbial community in the gut through either direct inhibition or indirect mechanisms involving alterations to host responses. We therefore examined the impact of rosuvastatin (RSV) on the community structure of the murine gastrointestinal microbiota...
February 16, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28209143/collaborative-leadership-and-the-implementation-of-community-based-fall-prevention-initiatives-a-multiple-case-study-of-public-health-practice-within-community-groups
#19
Maureen Markle-Reid, Cathy Dykeman, Jenny Ploeg, Caralyn Kelly Stradiotto, Angela Andrews, Susan Bonomo, Sarah Orr-Shaw, Niyati Salker
BACKGROUND: Falls among community-dwelling older adults are a serious public health concern. While evidence-based fall prevention strategies are available, their effective implementation requires broad cross-sector coordination that is beyond the capacity of any single institution or organization. Community groups comprised of diverse stakeholders that include public health, care providers from the public and private sectors and citizen volunteers are working to deliver locally-based fall prevention...
February 16, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28209054/confinement-of-ultrasmall-cu-znox-nanoparticles-in-metal-organic-frameworks-for-selective-methanol-synthesis-from-catalytic-hydrogenation-of-co2
#20
Bing An, Jingzheng Zhang, Kang Cheng, Pengfei Ji, Cheng Wang, Wenbin Lin
The interfaces of Cu/ZnO and Cu/ZrO2 play vital roles in the hydrogenation of CO2 to methanol by these composite catalysts. Surface structural reorganization and particle growth during catalysis deleteriously reduce these active interfaces, diminishing both catalytic activities and MeOH selectivities. Here we report the use of pre-assembled bpy and Zr6(μ3-O)4(μ3-OH)4 sites in UiO-bpy metal-organic frameworks (MOFs) to anchor ultrasmall Cu/ZnOx nanoparticles, thus preventing the agglomeration of Cu NPs and phase separation between Cu and ZnOx in MOF cavity-confined Cu/ZnOx nanoparticles...
February 17, 2017: Journal of the American Chemical Society
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