keyword
MENU ▼
Read by QxMD icon Read
search

Organic synthesis

keyword
https://www.readbyqxmd.com/read/29352749/tips-for-optimizing-organ-preservation-solutions
#1
Aneta Ostróżka-Cieślik, Barbara Dolińska, Florian Ryszka
Organ injury during ischemia is one of the clinical problems of today's transplantation. It occurs during warm ischemia time (WIT) when the blood flow is cut off and during cold ischemia when a graft is chilled in situ until the circulation is restored to the recipient organism. Fast cooling of the organ slows down metabolism and activates intracellular enzymes, which minimizes the effects of warm ischemia. Unfortunately, hypothermia also results in inhibition of ATP synthesis, cell swelling and intracellular acidity...
January 20, 2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29352156/comprehensive-reduction-of-amino-acid-set-in-a-protein-suggests-the-importance-of-prebiotic-amino-acids-for-stable-proteins
#2
Rei Shibue, Takahiro Sasamoto, Masami Shimada, Bowen Zhang, Akihiko Yamagishi, Satoshi Akanuma
Modern organisms commonly use the same set of 20 genetically coded amino acids for protein synthesis with very few exceptions. However, earlier protein synthesis was plausibly much simpler than modern one and utilized only a limited set of amino acids. Nevertheless, few experimental tests of this issue with arbitrarily chosen amino acid sets had been reported prior to this report. Herein we comprehensively and systematically reduced the size of the amino acid set constituting an ancestral nucleoside kinase that was reconstructed in our previous study...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351842/maintaining-a-healthy-proteome-during-oxidative-stress
#3
REVIEW
Dana Reichmann, Wilhelm Voth, Ursula Jakob
Some of the most challenging stress conditions that organisms encounter during their lifetime involve the transient accumulation of reactive oxygen and chlorine species. Extremely reactive to amino acid side chains, these oxidants cause widespread protein unfolding and aggregation. It is therefore not surprising that cells draw on a variety of different strategies to counteract the damage and maintain a healthy proteome. Orchestrated largely by direct changes in the thiol oxidation status of key proteins, the response strategies involve all layers of protein protection...
January 18, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29350515/rapid-one-pot-microwave-synthesis-of-mixed-linker-hybrid-zeolitic-imidazolate-framework-membranes-for-tunable-gas-separations
#4
Febrian Hillman, Jordan Brito, Hae-Kwon Jeong
The relatively slow and complex fabrication processes of polycrystalline metal-organic framework (MOF) membranes often times restrict their way to commercialization, despite their potential for molecular separation applications. Herein we report a rapid one-pot microwave synthesis of mixed linker hybrid zeolitic-imidazolate framework (ZIF) membranes consisting of 2-methylimidazolate (ZIF-8 linker) and benzimidazolate (ZIF-7 linker) linkers, termed ZIF-7-8 membranes. The fast-volumetric microwave heating in conjunction with unique counter diffusion of metal and linker solutions enabled unprecedented rapid synthesis of well-intergrown ZIF-7-8 membranes in ~ 90 s, the fastest MOF membrane preparation up to date...
January 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29350434/the-cystine-glutamate-exchanger-xct-slc7a11-is-expressed-in-significant-concentrations-in-a-subpopulation-of-astrocytes-in-the-mouse-brain
#5
Sigrid Ottestad-Hansen, Qiu Xiang Hu, Virgine Veronique Follin-Arbelet, Eduard Bentea, Hideyo Sato, Ann Massie, Yun Zhou, Niels Christian Danbolt
The cystine-glutamate exchanger (xCT) promotes glutathione synthesis by catalyzing cystine uptake and glutamate release. The released glutamate may modulate normal neural signaling and contribute to excitotoxicity in pathological situations. Uncertainty, however, remains as neither the expression levels nor the distribution of xCT have been unambiguously determined. In fact, xCT has been reported in astrocytes, neurons, oligodendrocytes and microglia, but most of the information derives from cell cultures. Here, we show by immunohistochemistry and by Western blotting that xCT is widely expressed in the central nervous system of both sexes...
January 19, 2018: Glia
https://www.readbyqxmd.com/read/29350417/hepatitis-c-virus-core-protein-induces-dysfunction-of-liver-sinusoidal-endothelial-cell-by-down-regulation-of-silent-information-regulator-1
#6
Li-Jie Sun, Jian-Wu Yu, Yu-Guang Shi, Xiao-Yu Zhang, Meng-Ni Shu, Mo-Yang Chen
Objective Hepatic fibrosis is a frequent feature of chronic hepatitis C virus (HCV) infection. Some evidence has suggested the potential role of silent information regulator 1 (SIRT1) in organ fibrosis. The aim of this study was to investigate the effect of HCV core protein on expression of SIRT1 of liver sinusoidal endothelial cell (LSEC) and function of LSEC. Methods LSECs were co-cultured with HepG2 cells or HepG2 cells expressing HCV core protein and LSECs cultured alone were used as controls. After co-culture, the activity and expression levels of mRNA and protein of SIRT1 in LSEC were detected by a SIRT1 fluorometric assay kit, real time-PCR (RT-PCR), Western blot, respectively...
January 19, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29349841/novel-mof-derived-co-n-c-bifunctional-catalysts-for-highly-efficient-zn-air-batteries-and-water-splitting
#7
Mingdao Zhang, Quanbin Dai, Hegen Zheng, Mindong Chen, Liming Dai
Metal-organic frameworks (MOFs) and MOF-derived materials have recently attracted considerable interest as alternatives to noble-metal electrocatalysts. Herein, the rational design and synthesis of a new class of Co@N-C materials (C-MOF-C2-T) from a pair of enantiotopic chiral 3D MOFs by pyrolysis at temperature T is reported. The newly developed C-MOF-C2-900 with a unique 3D hierarchical rodlike structure, consisting of homogeneously distributed cobalt nanoparticles encapsulated by partially graphitized N-doped carbon rings along the rod length, exhibits higher electrocatalytic activities for oxygen reduction and oxygen evolution reactions (ORR and OER) than that of commercial Pt/C and RuO2 , respectively...
January 19, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29349588/amphiregulin-enhances-cardiac-fibrosis-and-aggravates-cardiac-dysfunction-in-mice-with-experimental-myocardial-infarction-partly-through-activating-egfr-dependent-pathway
#8
Liang Liu, Xian Jin, Cui-Fen Hu, Ya-Ping Zhang, Zhong'e Zhou, Rong Li, Cheng-Xing Shen
Cardiac fibrosis (CF), a main process of ventricular remodeling after myocardial infarction (MI), plays a crucial role in the pathogenesis of heart failure (HF) post-MI. It is known that amphiregulin (AR) is involved in fibrosis of several organs. However, the expression of AR and its role post-MI are yet to be determined. This study aimed to investigate the impact of AR on CF post-MI and related mechanisms. Significantly upregulated AR expression was evidenced in the infarct border zone of MI mice in vivo and the AR secretion was enhanced in macrophages, but not in cardiac fibroblasts...
January 18, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29349459/a-versatile-single-molecular-precursor-for-the-synthesis-of-layered-oxide-cathode-materials-for-li-ion-batteries
#9
Maofan Li, Jiajie Liu, Tongchao Liu, Mingjian Zhang, Feng Pan
A carbonyl-bridged single molecular precursor LiTM(acac)3 [transition metal (TM) = cobalt/manganese/nickel (Co/Mn/Ni), acac = acetylacetone], featuring a one-dimensional chain structure, was designed and applied to achieve the layered oxide cathode materials: LiTMO2 (TM = Ni/Mn/Co, NMC). As examples, layered oxides, primary LiCoO2, binary LiNi0.8Co0.2O2 and ternary LiNi0.5Mn0.3Co0.2O2 were successfully prepared to be used as cathode materials. When they are applied to lithium-ion batteries (LIBs), all exhibit good electrochemical performance because of their unique morphology and great uniformity of element distribution...
January 19, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29348413/synthesis-of-luminescent-carbon-dots-with-ultrahigh-quantum-yield-and-inherent-folate-receptor-positive-cancer-cell-targetability
#10
Haifang Liu, Zhaohui Li, Yuanqiang Sun, Xin Geng, Yalei Hu, Hongmin Meng, Jia Ge, Lingbo Qu
Carbon dots (CDs) have a wide range of applications in chemical, physical and biomedical research fields. We are particularly interested in the use of CDs as fluorescence nanomaterials for targeted tumor cell imaging. One of the important aspects of success is to enhance the fluorescence quantum yields (QY) of CDs as well as increase their targetability to tumor cells. However, most of the reported CDs are limited by relative low QY. In the current study, for the first time, one-step synthesis of highly luminescent CDs by using folic acid (FA) as single precursor was obtained in natural water through hydrothermal method...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348235/digitization-of-multistep-organic-synthesis-in-reactionware-for-on-demand-pharmaceuticals
#11
Philip J Kitson, Guillaume Marie, Jean-Patrick Francoia, Sergey S Zalesskiy, Ralph C Sigerson, Jennifer S Mathieson, Leroy Cronin
Chemical manufacturing is often done at large facilities that require a sizable capital investment and then produce key compounds for a finite period. We present an approach to the manufacturing of fine chemicals and pharmaceuticals in a self-contained plastic reactionware device. The device was designed and constructed by using a chemical to computer-automated design (ChemCAD) approach that enables the translation of traditional bench-scale synthesis into a platform-independent digital code. This in turn guides production of a three-dimensional printed device that encloses the entire synthetic route internally via simple operations...
January 19, 2018: Science
https://www.readbyqxmd.com/read/29348001/zr-metal-organic-framework-and-derivatives-for-adsorptive-and-photocatalytic-removal-of-acid-dyes
#12
Kun-Yi Andrew Lin, Hongta Yang, Fu-Kong Hsu
  To investigate effects of modification of MOFs on removal of acid dyes via adsorption and photodegradation, zirconium-based MOF, UiO-66, and its derivatives were synthesized. UiO-66 derivatives were prepared by using amine (NH2)-containing ligand and incorporating carbon nanotubes (CNTs) and reduced graphene oxide (RGO). During the synthesis UiO-66-NH2, UiO-66-CNT and UiO-66-RGO, were obtained, respectively. While UiO-66-NH2 showed the enhanced adsorption capacity for acid dyes owing to the electrostatic attraction, CNTs were found to be the most effective addition to enhance the adsorption of acid dyes...
February 1, 2018: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/29346683/strigolactones-mediators-of-osmotic-stress-responses-with-a-potential-for-agrochemical-manipulation-of-crop-resilience
#13
Francesca Cardinale, Paolo Korwin Krukowski, Andrea Schubert, Ivan Visentin
After quickly touching upon general aspects of strigolactones biology and functions, including structure, synthesis and perception, this review focuses on the role and regulation of the strigolactone pathway during osmotic stress, in light of the most recent research developments. We discuss available data on organ-specific dynamics of strigolactone synthesis and interaction with abscisic acid in the acclimatization response, with emphasis on the ecophysiological implications of the effects on the stomatal closure process...
January 15, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29345917/anisotropic-assembly-of-ag52-and-ag76-nanoclusters
#14
Jia-Wei Liu, Lei Feng, Haifeng Su, Zhi Wang, Quan-Qin Zhao, Xingpo Wang, Chen-Ho Tung, Di Sun, Lan-Sun Zheng
Although there has been an upsurge of interest in anisotropic assembly of inorganic nanoparticles, atomically precise self-assembly of anisotropic (nonspherical) high-nuclearity metal clusters is extremely rare. Herein, we presented two novel silver nanoclusters, Ag52 (SD/Ag23) and Ag76 (SD/Ag24), which are interiorly templated by five MoO42- and a pair of Mo6O228- anions, respectively, and co-protected by bridging RSH and terminal diphosphine ligands exteriorly. Regiospe-cific distribution diphosphine ligands on the surface and the arrangement of multiple molybdate templates within the nanoclusters synergetically tailor their shapes to anisotropic oblate spheroid and elongated rod, respectively, as opposed to isotropic nanospheres...
January 18, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29345861/ruthenium-catalyzed-aerobic-oxidation-of-amines
#15
Debabrata Maiti, Goutam Kumar Lahiri, Ritwika Ray, Arijit Singha Hazari
Amine oxidation is one of the fundamental reactions in organic synthesis since it leads to a variety of value-added products like oximes, nitriles, imines and amides among many others. These products comprise the key N-containing building blocks in modern chemical industry, and such transformations when achieved in presence of molecular oxygen without using stoichiometric oxidants, are much preferred since they circumvent the production of unwanted wastes. In parallel, versatility of ruthenium catalysts in various oxidative transformations is well-documented...
January 18, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29345628/reversibility-and-intermediate-steps-as-key-tools-for-the-growth-of-extended-ordered-polymers-via-on-surface-synthesis
#16
Marco Di Giovannantonio, Giorgio Contini
Surface-confined polymerization is a bottom-up strategy to create one- and two-dimensional covalent organic nanostructures with a π-conjugated backbone, which are suitable to be employed in real-life electronic devices, due to their high mechanical resistance and electronic charge transport efficiency. This strategy makes it possible to change the properties of the final nanostructures by a careful choice of the monomer architecture (<i>i.e.</i> of its constituent atoms and their spatial arrangement)...
January 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29345386/quinoline-flanked-diketopyrrolopyrrole-copolymers-breaking-through-electron-mobility-over-6-cm2-v-1-s-1-in-flexible-thin-film-devices
#17
Zhenjie Ni, Huanli Dong, Hanlin Wang, Shang Ding, Ye Zou, Qiang Zhao, Yonggang Zhen, Feng Liu, Lang Jiang, Wenping Hu
Herein, the design and synthesis of novel π-extended quinoline-flanked diketopyrrolopyrrole (DPP) [abbreviated as QDPP] motifs and corresponding copolymers named PQDPP-T and PQDPP-2FT for high performing n-type organic field-effect transistors (OFETs) in flexible organic thin film devices are reported. Serving as DPP-flankers in backbones, quinoline is found to effectively tune copolymer optoelectric properties. Compared with TDPP and pyridine-flanked DPP (PyDPP) analogs, widened bandgaps and strengthened electron deficiency are achieved...
January 18, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29345067/supramolecular-gels-derived-from-the-salts-of-variously-substituted-phenylacetic-acid-and-dicyclohexyl-amine-design-synthesis-structures-and-dye-adsorption
#18
Parthasarathi Dastidar, Rajdip Roy, Tapas Kumar Adalder
A well-studied supramolecular synthon namely secondary ammonium monocarboxylate (SAM) was exploited to generate a new series of organic salts derived from variously substituted phenylacetic acid (PA) and dicyclohexyl amine (DCA) as potential low molecular weight gelators (LMWGs). As much as 25% of the SAM salts under study were gelators. The gels were characterized by rheology and the morphology of the gel networks was studied by high resolution electron microscopy. Single crystal and powder X-ray diffraction data were employed to study structure-property (gelation) correlation...
January 18, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29344901/imaging-characteristics-and-first-experience-of-68ga-thp-psma-a-novel-probe-for-rapid-kit-based-ga-68-labeling-and-pet-imaging-comparative-analysis-with-68ga-psma-i-t
#19
Thorsten Derlin, Sebastian Schmuck, Cathleen Juhl, Steffi Teichert, Johanna Zörgiebel, Hans-Jürgen Wester, Sophie M Schneefeld, Almut C A Walte, James T Thackeray, Tobias L Ross, Frank M Bengel
PURPOSE: [68Ga]Trishydroxypyridinone (THP)-prostate-specific membrane antigen (PSMA) is a novel tracer that can be labeled in one step by cold reconstitution of a kit with unprocessed generator eluate, targeting PSMA via the lysine-urea-glutamate (KuE) motif. The aim of this study was to evaluate the human imaging characteristics of [68Ga]THP-PSMA. PROCEDURES: [68Ga]THP-PSMA positron emission tomography (PET)/x-ray computed tomography (CT) was performed in 25 patients with biochemical recurrence after radical prostatectomy for prostate cancer...
January 17, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29343430/cardiolipin-synthesizing-enzymes-form-a-complex-that-interacts-with-cardiolipin-dependent-membrane-organizing-proteins
#20
Mauro Serricchio, Adriano Vissa, Peter K Kim, Christopher M Yip, G A McQuibban
The mitochondrial glycerophospholipid cardiolipin plays important roles in mitochondrial biology. Most notably, cardiolipin directly binds to mitochondrial proteins and helps assemble and stabilize mitochondrial multi-protein complexes. Despite their importance for mitochondrial health, how the proteins involved in cardiolipin biosynthesis are organized and embedded in mitochondrial membranes has not been investigated in detail. Here we show that human PGS1 and CLS1 are constituents of large protein complexes...
January 14, 2018: Biochimica et Biophysica Acta
keyword
keyword
42952
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"