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https://www.readbyqxmd.com/read/29667754/estrogen-regulated-expression-of-p450arom-genes-in-the-brain-and-ovaries-of-adult-female-indian-climbing-perch-anabas-testudineus
#1
Puja Pal, Sujata Roy Moulik, Shreyasi Gupta, Payel Guha, Suravi Majumder, Sourav Kundu, Buddhadev Mallick, Kousik Pramanick, Dilip Mukherjee
Cytochrome P450arom (CYP19), a product of cyp19a1 gene, catalyzes the conversion of androgens to estrogens and is essential for regulation of reproductive function in vertebrates. In the present study, we isolated partial cDNA encoding the ovarian (cyp19a1a) and brain (cyp19a1b) P450arom genes from adult female perch, Anabas testudineus and investigated their regulation by estrogen in vivo. Results demonstrated that cyp19a1a and cyp19a1b predominate in ovary and brain respectively, with quantity of both attuned to reproductive cycle...
April 18, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29667339/adjuvant-chemotherapy-in-patients-with-operable-granulosa-cell-tumors-of-the-ovary-a-surveillance-epidemiology-and-end-results-cohort-study
#2
Anton Oseledchyk, Renee L Gennarelli, Mario M Leitao, Carol A Aghajanian, Alexia Iasonos, Oliver Zivanovic, Dmitriy Zamarin
Adjuvant chemotherapy is recommended for patients with resected high-risk adult granulosa cell tumors (GCT), although strong data to support this are lacking. The objective of this study was to assess the outcomes of GCT patients, with the specific focus on patients that received adjuvant chemotherapy with curative intent (stage I-III), reported in a large national cancer registry. Data from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2013 were used for analysis. Patient and disease characteristics were extracted and analyzed for association with administration of chemotherapy...
April 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29667174/impact-of-prior-cancer-history-on-the-overall-survival-of-patients-newly-diagnosed-with-cancer-a-pan-cancer-analysis-of-the-seer-database
#3
Huaqiang Zhou, Yan Huang, Zeting Qiu, Hongyun Zhao, Wenfeng Fang, Yunpeng Yang, Yuanyuan Zhao, Xue Hou, Yuxiang Ma, Shaodong Hong, Ting Zhou, Yaxiong Zhang, Li Zhang
The population of cancer survivors with prior cancer is rapidly growing. Whether a prior cancer diagnosis interferes with outcome is unknown. We conducted a pan-cancer analysis to determine the impact of prior cancer history for patients newly diagnosed with cancer. We identified 20 types of primary solid tumors between 2004 to 2008 in the Surveillance, Epidemiology, and End Results (SEER) database. Demographic and clinicopathologic variables were compared by chi-squared test and t-test as appropriate. The propensity score-adjusted Kaplan-Meier method and Cox proportional hazards models were used to evaluate the impact of prior cancer on overall survival (OS)...
April 18, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29666332/expression-profiles-of-amh-and-foxl2-in-schizothorax-kozlovi-and-their-response-to-temperature-during-the-early-developmental-stage
#4
Yongfeng He, Xuge Wang, Xingbing Wu, Yongjiu Zhu, Deguo Yang
To elucidate the role of amh and foxl2 in sex differentiation of the teleost fish Schizothorax kozlovi, the full-length cDNAs were cloned from the mature testis and ovary by rapid amplification of cDNA ends (RACE), and their relative mRNA expression levels were determined by quantitative real-time polymerase chain reaction among tissues and temperature groups. The complete amh and foxl2 cDNAs of S. kozlovi were 2060 bp and 1750 bp, which encoded 568 and 306 amino acids, respectively. The amh were expressed only in gonads, while foxl2 was expressed in the gills, brain and gonads, both exhibiting relatively high tissue specificity...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29665458/granulosa-cell-tumor-of-ovary-a-systematic-review-of-recent-evidence
#5
EDITORIAL
Gabriel Levin, Roy Zigron, Rani Haj-Yahya, Liat S Matan, Amihai Rottenstreich
No abstract text is available yet for this article.
April 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29665393/comparative-experimental-theoretical-studies-on-the-egfr-dimerization-under-the-effect-of-egf-egf-analogues-binding-highlighting-the-importance-of-egf-egfr-interactions-at-site-iii-interface
#6
Masomeh Mehrabi, Hamid Mahdiuni, Hassan Rasouli, Kamran Mansouri, Mohsen Shahlaie, Reza Khodarahmi
Epidermal growth factor receptors (EGFRs) and their cytoplasmic tyrosine kinases play significant roles in cell proliferation and signaling. All the members of the EGFR/ErbB family are primary goals for cancer therapy, particularly for tumors of breast, cervix, ovaries, kidney, esophagus, prostate and non-small-cell lung carcinoma and head and neck tumors. However, the therapeutic ability of accessible anti-ErbB agents is limited. Therefore, recognizing EGF analogues or small organic molecules with high affinity for the extracellular domain of the EGFR is a critical target on cancer research...
April 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29665328/effects-of-exposure-to-acetaminophen-and-ibuprofen-on-fetal-germ-cell-development-in-both-sexes-in-rodent-and-human-using-multiple-experimental-systems
#7
Pablo Hurtado-Gonzalez, Richard A Anderson, Joni Macdonald, Sander van den Driesche, Karen Kilcoyne, Anne Jørgensen, Chris McKinnell, Sheila Macpherson, Richard M Sharpe, Rod T Mitchell
BACKGROUND: Analgesic exposure during pregnancy may affect aspects of fetal gonadal development that are targeted by endocrine disruptors. OBJECTIVES: We investigated whether therapeutically relevant doses of acetaminophen and ibuprofen affect germ cell (GC) development in human fetal testes/ovaries using in vitro and xenograft approaches. METHODS: Gonocyte (TFAP2C+ ) number was reduced relative to controls in first-trimester human fetal testes exposed in vitro to acetaminophen (-28%) or ibuprofen (-22%) and also in ovaries exposed to acetaminophen (-43%) or ibuprofen (-49%)...
April 16, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29665036/stable-mirna-overexpression-in-human-cap-cells-engineering-alternative-production-systems-for-advanced-manufacturing-of-biologics-using-mir-136-and-mir-3074
#8
Benjamin L Weis, Nadine Guth, Simon Fischer, Silke Wissing, Simon Fradin, Karl-Heinz Holzmann, René Handrick, Kerstin Otte
Chinese hamster ovary (CHO) cells still represent the major production host for therapeutic proteins. However, multiple limitations have been acknowledged leading to the search for alternative expression systems. CEVEC's amniocyte production (CAP) cells are human production cells demonstrated to enable efficient overexpression of recombinant proteins with human glycosylation pattern. However, CAP cells have not yet undergone any engineering approaches to optimize process parameters for a cheaper and more sustainable production of biopharmaceuticals...
April 17, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29664789/what-is-new-in-the-management-of-poor-ovarian-response-in-ivf
#9
Alberto Vaiarelli, Danilo Cimadomo, Nicolò Ubaldi, Laura Rienzi, Filippo Maria Ubaldi
PURPOSE OF REVIEW: The management and treatment of patients with poor ovarian response is still a controversial issue in IVF. Increasing evidences demonstrate that the number of oocytes retrieved after a controlled ovarian stimulation (COS) greatly influences the clinical outcome in terms of cumulative live birth per started cycle. For this reason, any COS should aim to optimize the number of oocytes according to the ovarian reserve of the patient. The aim of this review is to provide an overview of new strategies proposed to manage poor responders according to the novel POSEIDON classification...
April 16, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29664663/effects-of-probiotic-supplementation-on-hormonal-profiles-biomarkers-of-inflammation-and-oxidative-stress-in-women-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#10
Maryam Karamali, Sara Eghbalpour, Sajad Rajabi, Mehri Jamilian, Fereshteh Bahmani, Maryam Tajabadi-Ebrahimi, Fariba Keneshlou, Seyyed Mehdi Mirhashemi, Maryam Chamani, Sara Hashem Gelougerdi, Zatollah Asemi
BACKGROUND: To the best of our knowledge, data on effects of probiotic administration on hormonal profiles, biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome (PCOS) are scarce. This investigation was conducted to assess the effects of probiotic supplementation on hormonal profiles, biomarkers of inflammation and oxidative stress in women with PCOS. METHODS: This randomized, double-blind, placebo-controlled trial was conducted on 60 women with PCOS, aged 18-40 years old...
January 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29664055/identification-of-potential-biomarkers-for-urine-metabolomics-of-polycystic-ovary-syndrome-based-on-gas-chromatography-mass-spectrometry
#11
Ying Zou, Fu-Fan Zhu, Chao-Ying Fang, Xi-Yue Xiong, Hong-Yun Li
Background: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, and it's diagnosis is difficult. The aim of this study was to investigate the metabolic profiles of PCOS patients by analyzing urine samples and identify useful biomarkers for diagnosis of PCOS. Methods: This study was carried out in the Department of Obstetrics and Gynecology of the Maternal and Child Health Hospital of Hunan Province from December 2014 to July 2016. In this study, the urine samples of 21 women with PCOS and 16 healthy controls were assessed through gas chromatography-mass spectrometry to investigate the urine metabolite characteristics of PCOS and identify useful biomarkers for the diagnosis of this disorder...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29663637/reproductive-health-obesity-and-cardiometabolic-risk-factors-among-samoan-women
#12
H Maredia, N L Hawley, G Lambert-Messerlian, U Fidow, M S Reupena, T Naseri, S T McGarvey
OBJECTIVES: Obesity leads to deleterious effects on not only cardiovascular health but also on the reproductive health of women. We estimate the prevalence of menstrual irregularity and of polycystic ovarian syndrome (PCOS) in Samoan women, among whom obesity prevalence is extremely high. We explore the association of these reproductive health conditions with adiposity, cardiometabolic risk factors, and androgen levels. METHODS: A cross-sectional sample of Samoan women 25-39 years of age (n = 470) from a larger population-based genome-wide association study of adiposity and cardiometabolic disease was assessed for the prevalence of oligomenorrhea/amenorrhea (OM/AM) using a self-reported questionnaire...
April 16, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29663591/research-progress-on-the-role-of-melatonin-and-its-receptors-in-animal-reproduction-a-comprehensive-review
#13
REVIEW
H S Talpur, I B Chandio, R D Brohi, T Worku, Z Rehman, D Bhattarai, F Ullah, L JiaJia, L Yang
Melatonin and its receptors play a crucial role in the regulation of the animal reproductive process, primarily in follicular development. However, the role that melatonin performs in regulating hormones related with reproduction remains unclear. Melatonin and its receptors are present both in female and male animals' organs, such as ovaries, heart, brain and liver. Melatonin regulates ovarian actions and is a key mediator of reproductive actions. Melatonin has numerous effects on animal reproduction, such as protection of gametes and embryos, response to clock genes, immune-neuroendocrine, reconciliation of seasonal variations in immune function, and silence or blockage of genes...
April 16, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29662968/adnexal-masses-or-perineural-tarlov-cysts-differentiation-by-imaging-techniques-a-case-report
#14
Firoozeh Ahmadi, Farnaz Akhbari
Background: Perineural cysts formed within the nerve-root sheath at the dorsal root ganglion. They are most commonly located in the arachnoid covering the junction of the dorsal ganglion and nerve root. They are usually asymptomatic, incidental findings, usually located in the lumbar and sacral region of the spinal canal. It is important to consolidate the imaging findings of this rare disease so clinicians can become more clinically relevant in the evaluation of these cysts. Case: Herein we report a case of perineural cyst misdiagnosed with hydrosalpinx by pelvic ultrasonography and finally diagnosed with magnetic resonance image...
September 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29662966/healthy-eating-index-in-women-with-polycystic-ovary-syndrome-a-case-control-study
#15
Mahbobeh Sadat Hosseini, Alireza Dizavi, Hosein Rostami, Karim Parastouei, Saeed Esfandiari
Background: Despite many effort to identify and control the factors involved in polycystic ovary syndrome (PCOS), there are no available reports indicating the association of healthy eating index (HEI) and PCOS. Objective: The present study has been conducted to examine the relationship between HEI and PCOS. Materials and Methods: In this case-control study, the study population comprised 297 women aged 20-40 yr referred to Baqiyatallah Hospital Clinics, Tehran, Iran in two groups: case group (n=99) and control group (n=198)...
September 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29662963/facilitating-and-inhibiting-factors-related-to-treatment-adherence-in-women-with-polycystic-ovary-syndrome-a-qualitative-study
#16
Fatemeh Bazarganipour, Seyed Abdolvahab Taghavi, Helen Allan, Nazafarin Hosseini
Background: Adherence issues in polycystic ovary syndrome (PCOS) patients have not been examined thoroughly. Patients report prolonged periods of treatment and side effects of the drug as the most common reason for withdrawal from treatment. To improve the effective management of PCOS patients, it is fundamental to understand facilitating and inhibiting factors to treatment adherence. Objective: To explore facilitating/inhibiting factors related to treatment adherence among PCOS patients...
September 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29662904/identification-of-differentially-expressed-genes-in-porcine-ovaries-at-proestrus-and-estrus-stages-using-rna-seq-technique
#17
Songbai Yang, Xiaolong Zhou, Yue Pei, Han Wang, Ke He, Ayong Zhao
Estrus is an important factor for the fecundity of sows, and it is involved in ovulation and hormone secretion in ovaries. To better understand the molecular mechanisms of porcine estrus, the expression patterns of ovarian mRNA at proestrus and estrus stages were analyzed using RNA sequencing technology. A total of 2,167 differentially expressed genes (DEGs) were identified ( P ≤ 0.05, |log2   Ratio| ≥ 1), of which 784 were upregulated and 1,383 were downregulated in the estrus compared with the proestrus group...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29662660/clinical-outcomes-of-women-with-ovarian-metastases-of-colorectal-cancer-treated-with-oophorectomy-with-respect-to-their-somatic-mutation-profiles
#18
Yoshiko Mori, Akihiro Nyuya, Kazuya Yasui, Toshiaki Toshima, Takashi Kawai, Fumitaka Taniguchi, Keisuke Kimura, Ryo Inada, Masahiko Nishizaki, Junko Haraga, Keiichiro Nakamura, Yuzo Umeda, Hiroyuki Kishimoto, Toshiyoshi Fujiwara, Yosuke Katata, Yoshiyuki Yamaguchi, Takeshi Nagasaka
We clarified the clinical prevalence of ovarian metastases from colorectal cancers (CRCs) in 296 female patients with CRC and evaluated clinical outcomes with relation to their mutational profiles, such as BRAF/KRAS mutation and microsatellite instability (MSI) status. The female CRCs were categorised into three subsets: CRCs with ovarian metastases [6.4% ( n = 19), 5-year overall survival (OS) = 24.7%], CRCs with extra-ovarian metastases only [32.4% ( n = 96), 5-year OS = 34.5%] and CRCs without any recurrence or metastasis [61...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662617/premature-ovarian-aging-in-brca-carriers-a-prototype-of-systemic-precocious-aging
#19
Irit Ben-Aharon, Mattan Levi, David Margel, Rinat Yerushalmi, Shulamith Rizel, Shlomit Perry, Eran Sharon, Noa Hasky, Ronit Abir, Benny Fisch, Ana Tobar, Ruth Shalgi, Salomon Marcello Stemmer
Purpose: Though former evidence implies a correlation of breast cancer susceptibility gene ( BRCA ) mutation with reduced ovarian reserve, the data is yet inconsistent. Our aim was to investigate biomarkers of ovarian aging in a cohort of young healthy carriers of the BRCA mutation. We hypothesized that the role played by BRCA genes in aging pathways is not exclusive to the ovary. Experimental Design: Healthy female BRCA carriers, 40 years or younger and healthy male BRCA carriers, 50 years or younger, were enrolled in the study...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662284/a-comparative-study-on-quantitative-assessment-of-blood-flow-and-vascularization-in-polycystic-ovary-syndrome-patients-and-normal-women-using-three-dimensional-power-doppler-ultrasonography
#20
Nitasha Garg, Harkiran Kaur Khaira, Manjot Kaur, Smita Sinha
Purpose of the Study: To compare the quantitative assessment of blood flow and vascularization of ovaries in polycystic ovary syndrome patients and normal women using three-dimensional power Doppler ultrasonography. Methods: This cross-sectional quantitative study was conducted on women of reproductive age group (15-45 years) attending Gynaecology OPD AIMSR, Bathinda, Punjab. Thirty women were enrolled in polycystic ovarian syndrome (PCOS) group and 30 healthy women in control group...
April 2018: Journal of Obstetrics and Gynaecology of India
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