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Anders Bjørnsgaard Aas, Marie Louise Davey, Håvard Kauserud
The formation of chimeric sequences can create significant methodological bias in PCR-based DNA metabarcoding analyses. During mixed-template amplification of barcoding regions, chimera formation is frequent and well documented. However, profiling of fungal communities typically uses the more variable rDNA region ITS. Due to a larger research community, tools for chimera detection have been developed mainly for the 16S/18S markers. However, these tools are widely applied to the ITS region without verification of their performance...
October 24, 2016: Molecular Ecology Resources
Aymard Didier Tamafo Fouegue, Julius Numbonui Ghogomu, Désiré Bikélé Mama, Nyiang Kennet Nkungli, Elie Younang
The chelating ability of juglone and two of its derivatives towards Fe(2+)ion and the antioxidant activity (AOA) of the resulting chelates and complexes (in the presence of H2O and CH3OH as ligands) in gas phase is reported via bond dissociation enthalpy, ionization potential, proton dissociation enthalpy, proton affinity, and electron transfer enthalpy. The DFT/B3LYP level of theory associated with the 6-31+G(d,p) and 6-31G(d) Pople-style basis sets on the atoms of the ligands and the central Fe(II), respectively, was used...
2016: Bioinorganic Chemistry and Applications
Ricardo Soares de Sant'Ana, Jacó Saraiva de Castro Mattos, Anderson Soares da Silva, Luanes Marques de Mello, Altacílio Aparecido Nunes
Objective: To evaluate association of sociodemographic, anthropometric, and epidemiological factors with result of mammogram in women undergoing breast cancer screening. Methods: This is a cross-sectional study with data obtained through interviews, anthropometric measurements, and mammography of 600 women aged 40 to 69 years at the Preventive Medicine Department of Hospital de Câncer de Barretos, Brazil, in 2014. The results of these examinations in the BI-RADS categories 1 and 2 were grouped and classified in this study as normal mammogram outcome, and those of BI-RADS categories 3, 4A, 4B, 4C, and 5 were grouped and classified as altered mammogram outcome...
July 2016: Einstein
Mamas A Mamas, Sudhakar George, Karim Ratib, Chun Shing Kwok, Abdelnasir Elkhazin, Kully Sandhu, Julie Stubbs, Pamela Luxford, James Nolan
BACKGROUND: While the uptake of transradial access site is growing, there are concerns about associated radial injury. We report a feasibility study of a technique that enables both 5Fr diagnostic and PCI cases to be undertaken without an arterial sheath using conventional diagnostic and guide catheters with a modified balloon assisted tracking (BAT) technique. METHODS: We performed a prospective single center pilot study to assess the feasibility and effectiveness of sheathless radial artery access and BAT to perform coronary angiography and angioplasty using conventional 5 Fr diagnostic and guide catheters...
September 18, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Adrian D Wood, Gurdeep S Mannu, Allan B Clark, Somsak Tiamkao, Kannikar Kongbunkiat, Joao H Bettencourt-Silva, Kittisak Sawanyawisuth, Narongrit Kasemsap, Raphae S Barlas, Mamas Mamas, Phyo Kyaw Myint
BACKGROUND AND PURPOSE: Rheumatic valvular heart disease is associated with the increased risk of cerebrovascular events, although there are limited data on the prognosis of patients with rheumatic mitral valve disease (RMVD) after stroke. METHODS: We examined the association between RMVD and both serious and common cardiovascular and noncardiovascular (respiratory and infective) complications in a cohort of hospitalized stroke patients based in Thailand. Factors associated with in-hospital mortality were also explored...
October 4, 2016: Stroke; a Journal of Cerebral Circulation
Kyriakos Souliotis, Eirini Agapidaki, Lily Evangelia Peppou, Chara Tzavara, George Samoutis, Mamas Theodorou
Although the importance of patient participation in the design and evaluation of health programs and services is well-documented, there is scarcity of research with regard to patient association (PA) participation in health policy decision-making processes. To this end, the present study aimed to validate further a previously developed instrument as well as to investigate the degree of PA participation in health policy decision-making in Cyprus. A convenient sample of 114 patients-members of patients associations took part in the study...
June 20, 2016: International Journal of Health Policy and Management
Dustin Wayne Demoin, Ashley N Dame, William D Minard, Fabio Gallazzi, Gary L Seickman, Tammy L Rold, Nicole Bernskoetter, Michael E Fassbender, Timothy J Hoffman, Carol A Deakyne, Silvia S Jurisson
INTRODUCTION: Targeted radiotherapy using the bifunctional chelate approach with (186/188)Re(V) is challenging because of the susceptibility of monooxorhenium(V)-based complexes to oxidize in vivo at high dilution. A monoamine-monoamide dithiol (MAMA)-based bifunctional chelating agent was evaluated with both rhenium and technetium to determine its utility for in vivo applications. METHODS: A 222-MAMA chelator, 222-MAMA(N-6-Ahx-OEt) bifunctional chelator, and 222-MAMA(N-6-Ahx-BBN(7-14)NH2) were synthesized, complexed with rhenium, radiolabeled with (99m)Tc and (186)Re (carrier added and no carrier added), and evaluated in initial biological distribution studies...
August 31, 2016: Nuclear Medicine and Biology
Ameh Omede, Min Zi, Sukhpal Prehar, Arfa Maqsood, Nicholas Stafford, Mamas Mamas, Elizabeth Cartwright, Delvac Oceandy
The G-protein-coupled receptors (GPCRs) family of proteins play essential roles in the heart, including in the regulation of cardiac hypertrophy. One member of this family, the oxoglutarate receptor 1 (OXGR1), may have a crucial role in the heart because it acts as a receptor for α-ketoglutarate, a metabolite that is elevated in heart failure patients. OXGR1 is expressed in the heart but its precise function during cardiac pathophysiological process is unknown. Here we used both in vivo and in vitro approaches to investigate the role of OXGR1 in cardiac hypertrophy...
October 28, 2016: Biochemical and Biophysical Research Communications
Pensee Wu, Chun Shing Kwok, Randula Haththotuwa, Rafail A Kotronias, Aswin Babu, Anthony A Fryer, Phyo K Myint, Carolyn A Chew-Graham, Mamas A Mamas
AIMS/HYPOTHESIS: Pre-eclampsia is a pregnancy-specific multisystem disorder and a state of physiological insulin resistance. Our aim was to systematically evaluate and quantify the evidence on the relationship between pre-eclampsia and the future risk of diabetes. METHODS: We conducted a systematic review and meta-analysis of studies that evaluated diabetes in women with and without pre-eclampsia. We performed a systematic search of MEDLINE and EMBASE to identify relevant studies...
September 19, 2016: Diabetologia
Annmarie A Lyles, Colleen Loomis, Scherezade K Mama, Sameer Siddiqi, Rebecca E Lee
Online, virtual group interactions may help adherence to health promotion programs. The purpose of this study was to explore longitudinal relationships among dimensions of group cohesion and group-interaction variables to inform and improve group-based strategies within programs aimed at promoting physical activity in virtual communities. In all, 56 online virtual users completed a group dynamics-based physical activity promotion intervention and assessments of group cohesion and group interaction at baseline and 4 weeks...
September 14, 2016: Journal of Health Psychology
Cha-Nam Shin, Erica Soltero, Scherezade K Mama, Christopher Sunseri, Rebecca E Lee
Psychological stressors can contribute to adverse health outcomes and lead to health disparities. To examine associations among psychological stressors, coping, blood pressure, body mass index, and body fat in ethnic minority women, we conducted a secondary analysis using data from 178 African American and Hispanic/Latina women who completed measures of perceived racial discrimination and stress, coping, blood pressure, and body composition. The mean age of participants was 45.3 (±9.3 years), and most were obese (74...
September 13, 2016: Clinical Nursing Research
Ana Maria Delgado-Marquez, Vanessa Gargallo-Moneva, Jose Luis Rodriguez-Peralto, Sara Lopez-Gomez
Diffuse cutaneous angiomatosis is one of the reactive angiomatoses. Historically, it is associated with lesions located in the lower extremities. Breast localization is uncommon, but may be under-reported. We report a non-smoking woman who exhibited this vascular condition of both breasts.
2016: Dermatology Online Journal
Chanwit Tribuddharat, Pintip Pongpech, Angkana Charoenwatanachokchai, Somchai Lokpichart, Somporn Srifuengfung, Suthatta Sonprasert
We studied antimicrobial susceptibility and the current rates of blaTEM-1 and blaTEM-135. Neisseria gonorrhoeae 370 isolates were tested by using disk diffusion method and found 100% susceptible to cefixime, ceftriaxone, cefotaxime, ceftazidime, cefepime, spectinomycin and azithromycin. They were resistant to penicillin (85.7%), ciprofloxacin (88.0%), ofloxacin (97.4%), and tetracycline (89.1%). Penicillinase-producing N. gonorrhoeae (PPNG) was 83.8% which 70.0% was further identified as PPNG plus tetracycline resistant N...
August 31, 2016: Japanese Journal of Infectious Diseases
Tuan Ngoc Minh Nguyen, Helmut Hotzel, John Njeru, Joyce Mwituria, Hosny El-Adawy, Herbert Tomaso, Heinrich Neubauer, Hafez M Hafez
BACKGROUND: Thermophilic Campylobacter species are a major cause of bacterial foodborne diarrhoea in humans worldwide. Poultry and their products are the predominant source for human campylobacteriosis. Resistance of Campylobacter to antibiotics is increasing worldwide, but little is known about the antibiotic resistance in Campylobacter isolated from chicken in Kenya. In this study, 35 suspected Campylobacter strains isolated from faeces and cloacal swabs of chicken were tested for their susceptibility to seven antibiotics using a broth microdilution assay and molecular biological investigations...
2016: Gut Pathogens
Wilson Cintra Junior, Miguel Luiz Antonio Modolin, Rodrigo Itocazo Rocha, Rolf Gemperli
OBJECTIVE: to evaluate patient satisfaction and surgical results obtained after mastopexy with breast implant inclusion. METHODS: we conducted a prospective study of 20 consecutive female patients with a mean age of 39.9 years, submitted to augmentation mastopexy. We applied semi-directed psychological interviews pre and postoperatively. The answers to the evaluations were tabulated, categorized, and allowed patient satisfaction analysis. We evaluated surgical results through photographic analysis of three independent plastic surgeons, in the pre and postoperative periods, when scores were attributed to the following items: breasts shape, breasts volume, breasts symmetry, nipple-areolar complex position, and scar quality and extent...
May 2016: Revista do Colégio Brasileiro de Cirurgiões
Khaled Yazji, Fairoz Abdul, Senthil Elangovan, Nick Ossei-Gerning, Anirban Choudhury, James Cockburn, Richard Anderson, Mamas Mamas, Tim Kinnaird
Although randomized trial data suggest that complete revascularization improves outcomes after percutaneous coronary intervention (PCI), the impact of differing revascularization strategies in octogenarians is not well defined. We performed a retrospective analysis, which was conducted of 9,628 consecutive patients who underwent PCI at a large UK center. Octogenarians were more likely to have significant co-morbidity, a higher Mehran bleed risk score (24.5 ± 6.8 vs 13.3 ± 7.4, p <0.0001), and more complex disease (baseline SYNTAX score 18...
October 15, 2016: American Journal of Cardiology
Tim Kinnaird, Chun Shing Kwok, Aditya Narain, Rob Butler, Nicholas Ossei-Gerning, Peter Ludman, Neil Moat, Richard Anderson, Mamas A Mamas
We performed a meta-analysis of the studies comparing the efficacy and safety of coronary artery bypass surgery against percutaneous coronary intervention with drug-eluting stents (PCI-DES) in patients with isolated LAD disease. Because of the limited randomized trial data, the optimal revascularization strategy for patients with isolated LAD disease remains uncertain. Using MEDLINE and EMBASE to source data, 11 studies (3 randomized trials and 8 cohort studies) including 5,044 participants were identified...
October 15, 2016: American Journal of Cardiology
Emmanuel Wafo, Lydia Abou, Alain Nicolay, Pierre Boissery, Thierry Perez, Rose Ngono Abondo, Cédric Garnier, Mama Chacha, Henri Portugal
This study evaluated the distribution of polychlorinated biphenyls (PCBs) in 39 surface sediment samples and four cores collected in Toulon Bay, a semiclosed area submitted to various anthropogenic inputs. The concentration of PCBs in the superficial sediment samples ranged from 1.7 to 2530 ng g(-1) dry weight. The spatial distribution of these compounds suggested that the high concentrations of these contaminants are located in the small bay and are related to human activities. In the larger bay, the concentrations were in the same order of magnitude than those reported in others locations around the world...
2016: SpringerPlus
Biswadeep Das, Saumya Patra, Chinmay Behera, Mryutunjay Suar
Vitamin D has potent antimicrobial and anti-inflammatory properties. Vitamin D deficiency has been shown to be associated with the risk of vulnerability to different infectious diseases, such as neonatal sepsis. Polymorphisms in vitamin D receptor (VDR) gene can influence the expression of vitamin D in individuals. Hence, it is essential to study the vitamin D status and VDR gene polymorphisms for assessing neonatal sepsis risk. In this study, we assessed the serum 25(OH)D, the main circulating form of vitamin D and VDR polymorphism on 120 subjects in a case-control approach, recruiting 60 subjects in each category...
August 14, 2016: Infection, Genetics and Evolution
Raphae S Barlas, Katie Honney, Yoon K Loke, Stephen J McCall, Joao H Bettencourt-Silva, Allan B Clark, Kristian M Bowles, Anthony K Metcalf, Mamas A Mamas, John F Potter, Phyo K Myint
BACKGROUND: The impact of hemoglobin levels and anemia on stroke mortality remains controversial. We aimed to systematically assess this association and quantify the evidence. METHODS AND RESULTS: We analyzed data from a cohort of 8013 stroke patients (mean±SD, 77.81±11.83 years) consecutively admitted over 11 years (January 2003 to May 2015) using a UK Regional Stroke Register. The impact of hemoglobin levels and anemia on mortality was assessed by sex-specific values at different time points (7 and 14 days; 1, 3, and 6 months; 1 year) using multiple regression models controlling for confounders...
2016: Journal of the American Heart Association
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