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https://www.readbyqxmd.com/read/29775088/an-assessment-of-the-uk-inpatient-care-for-heart-failure-patients-with-diabetes
#1
Lihua Wu, Jackie Cleator, Mamas Mamas, Christi Deaton
BACKGROUND: Diabetes is a common co-morbidity for patients with heart failure. Diabetes as a co-morbidity means that inpatient care should focus on both conditions to maximize the treatment regimen. However, this pressing issue is not widely researched and so it is unclear whether the acute care management needs of these patients are being met. AIMS: (1) To assess the differences in the number of hospital readmissions between patients with heart failure and patients with heart failure-diabetes; (2) to assess the use of integrated care approach for patients with heart failure-diabetes during the index heart failure-related admission; (3) to explore patient experiences of admissions...
May 1, 2018: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29743163/health-economic-analysis-of-access-site-practice-in-england-during-changes-in-practice-insights-from-the-british-cardiovascular-interventional-society
#2
Mamas A Mamas, Jon Tosh, Will Hulme, Nicki Hoskins, George Bungey, Peter Ludman, Mark de Belder, Chun Shing Kwok, Nathalie Verin, Tim Kinnaird, Ewan Bennett, Nick Curzen, James Nolan, Evangelos Kontopantelis
BACKGROUND: Transradial access (TRA) for percutaneous coronary intervention (PCI) is associated with a reduced risk of mortality compared with transfemoral access, access site-related bleeding complications, and shorter length of stay. The budget impact from a healthcare system that has largely transitioned to TRA for PCI has not been previously published. METHODS AND RESULTS: Data from 323 656 patients undergoing PCI between 2010 and 2014 were obtained from the British Cardiovascular Intervention Society database...
May 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29742463/the-comparison-of-mama-pcr-and-sscp-pcr-to-study-chromosomal-resistance-against-ciprofloxacin-and-nalidixic-acid-in-escherichia-coli-and-klebsiella-pneumoniae
#3
Behnam Hashemi, Maryam Abdollahi, Alireza Rafiei, Ali Pourmohammad, Mohammad Ahanjan, Masoud Moghadaszadeh, Shima Rashidian
The mutation in gyrA and parC genes alters amino acids. Also, it causes resistance against Fluoroquinolones in E. coli and K. pneumoniae. The purpose of this study was to diagnose the significant mutation of gyrA (ser83-asp87) and parC (ser80-glu84) genes through using MAMA PCR and SSCP PCR methods. In so doing, the isolated samples were collected. Then, utilizing agar disc diffusion method, the reserchers performed antibiotic sensitivity test. Moreover, Fluoroquinolones resistance was confirmed by E-test method (MIC experiment)...
May 6, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29741247/prenatal-and-preimplantation-diagnosis-of-hemoglobinopathies
#4
REVIEW
C Vrettou, G Kakourou, T Mamas, J Traeger-Synodinos
The hemoglobinopathies, as a group, are one of the most common serious monogenic diseases in the world. An accepted and widely adopted approach to reduce the number of new cases involves carrier-screening programs, with the option of prenatal diagnosis (PND) or preimplantation diagnosis (preimplantation genetic testing for monogenic disease, PGT-M) for carrier couples. The aim of PND is to provide an accurate result as early in pregnancy as possible, which necessitates prior identification of the parental disease-causing mutations, as well as safe and timely biopsy of fetal material...
May 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29733856/biogenesis-of-the-bc-1-complex-of-the-mitochondrial-respiratory-chain
#5
REVIEW
Mama Ndi, Lorena Marin-Buera, Roger Salvatori, Abeer Prakash Singh, Martin Ott
The oxidative phosphorylation system contains four respiratory chain complexes that connect the transport of electrons to oxygen with the establishment of an electrochemical gradient over the inner membrane for ATP synthesis. Due to the dual genetic source of the respiratory chain subunits, its assembly requires a tight coordination between nuclear and mitochondrial gene expression machineries. In addition, dedicated assembly factors support the step-by-step addition of catalytic and accessory subunits as well as the acquisition of redox cofactors...
May 4, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29726633/the-impact-of-diabetes-on-the-prognostic-value-of-left-ventricular-function-following-percutaneous-coronary-intervention-insights-from-the-british-cardiovascular-intervention-society
#6
Matthew Jackson, David Austin, Chun Shing Kwok, Muhammad Rashid, Evan Kontopantelis, Peter Ludman, Mark de Belder, Mamas A Mamas, Azfar Zaman
OBJECTIVES: To study the relationship between diabetes mellitus (DM) and left ventricular (LV) function on outcomes following percutaneous coronary intervention (PCI). BACKGROUND: DM is a growing public health challenge worldwide and a significant risk factor for cardiovascular disease and heart failure. METHODS: All PCI procedures performed between 2006 and 2013 with LV function and diabetic status recorded in the BCIS-NICOR database were included...
May 4, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29706594/patients-perspectives-on-how-to-decrease-the-burden-of-treatment-a-qualitative-study-of-hiv-care-in-sub-saharan-africa
#7
Viet-Thi Tran, Eugene Messou, Mariam Mama Djima, Philippe Ravaud, Didier K Ekouevi
OBJECTIVE: Patients living with HIV infection (PLWH) in sub-Saharan Africa face an important burden of treatment related to everything they do to take care of their health: doctor visits, tests, regular refills, travels, and so on. In this study, we involved PLWH in proposing ideas on how to decrease their burden of treatment and assessed to what extent these propositions could be implemented in care. METHODS: Adult PLWH recruited in three HIV care centres in Côte d'Ivoire participated in qualitative interviews starting with ' What do you believe are the most important things to change in your care to improve your burden of treatment? ' Two independent investigators conducted a thematic analysis to identify and classify patients' propositions to decrease their burden of treatment...
April 29, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29627809/antithrombotic-therapy-in-patients-receiving-saphenous-vein-coronary-artery-bypass-grafts-a-protocol-for-a-systematic-review-and-network-meta-analysis
#8
Karla Solo, Janet Martin, Shahar Lavi, Conrad Kabali, Ava John-Baptiste, Immaculate F Nevis, Tawfiq Choudhury, Mamas A Mamas, Rodrigo Bagur
INTRODUCTION: The current evidence for the prevention of saphenous vein graft failure (SVGF) after coronary artery bypass graft (CABG) surgery consists of direct head-to-head comparison of treatments (including placebo) in randomised-controlled trials (RCTs) and observational studies. However, summarising the evidence using traditional pairwise meta-analyses does not allow the inclusion of data from treatments that have not been compared head to head. Exclusion of such comparisons could impact the precision of pooled estimates in a meta-analysis...
April 7, 2018: BMJ Open
https://www.readbyqxmd.com/read/29622145/burden-of-30-day-readmissions-after-percutaneous-coronary-intervention-in-833-344-patients-in-the-united-states-predictors-causes-and-cost-insights-from-the-nationwide-readmission-database
#9
Chun Shing Kwok, Sunil V Rao, Jessica E Potts, Evangelos Kontopantelis, Muhammad Rashid, Tim Kinnaird, Nick Curzen, James Nolan, Rodrigo Bagur, Mamas A Mamas
OBJECTIVES: This study aimed to examine the 30-day unplanned readmissions rate, predictors of readmission, causes of readmissions, and clinical impact of readmissions after percutaneous coronary intervention (PCI). BACKGROUND: Unplanned rehospitalizations following PCI carry significant burden to both patients and the local health care economy and are increasingly considered as an indicator of quality of care. METHODS: Patients undergoing PCI between 2013 and 2014 in the U...
April 9, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29601061/revascularizing-coronary-artery-disease-in-patients-undergoing-transcatheter-aortic-valve-implantation
#10
COMMENT
Rafail A Kotronias, Mamas A Mamas, Rodrigo Bagur
No abstract text is available yet for this article.
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29584734/comorbidity-health-pathways-in-heart-failure-patients-a-sequences-of-regressions-analysis-using-cross-sectional-data-from-10-575-patients-in-the-swedish-heart-failure-registry
#11
Claire A Lawson, Ivonne Solis-Trapala, Ulf Dahlstrom, Mamas Mamas, Tiny Jaarsma, Umesh T Kadam, Anna Stromberg
BACKGROUND: Optimally treated heart failure (HF) patients often have persisting symptoms and poor health-related quality of life. Comorbidities are common, but little is known about their impact on these factors, and guideline-driven HF care remains focused on cardiovascular status. The following hypotheses were tested: (i) comorbidities are associated with more severe symptoms and functional limitations and subsequently worse patient-rated health in HF, and (ii) these patterns of association differ among selected comorbidities...
March 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29583040/effects-of-mk-467-hydrochloride-and-hyoscine-butylbromide-on-cardiorespiratory-and-gastrointestinal-changes-induced-by-detomidine-hydrochloride-in-horses
#12
Heidi A Tapio, Marja R Raekallio, Anna Mykkänen, Khursheed Mama, Jóse L Mendez-Angulo, Heidi Hautajärvi, Outi M Vainio
OBJECTIVE To compare the effects of MK-467 and hyoscine butylbromide on detomidine hydrochloride-induced cardiorespiratory and gastrointestinal changes in horses. ANIMALS 6 healthy adult horses. PROCEDURES Horses received detomidine hydrochloride (20 μg/kg, IV), followed 10 minutes later by MK-467 hydrochloride (150 μg/kg; DET-MK), hyoscine butylbromide (0.2 mg/kg; DET-HYO), or saline (0.9% NaCl) solution (DET-S), IV, in a Latin square design. Heart rate, respiratory rate, rectal temperature, arterial and venous blood pressures, and cardiac output were measured; blood gases and arterial plasma drug concentrations were analyzed; selected cardiopulmonary variables were calculated; and sedation and gastrointestinal borborygmi were scored at predetermined time points...
April 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29579219/operator-volume-is-not-associated-with-mortality-following-percutaneous-coronary-intervention-insights-from-the-british-cardiovascular-intervention-society-registry
#13
William Hulme, Matthew Sperrin, Nick Curzen, Tim Kinnaird, Mark A De Belder, Peter Ludman, Chun Shing Kwok, Chris P Gale, James Cockburn, Evangelos Kontopantelis, Mamas A Mamas
Aims: The relationship between operator volume and outcomes for percutaneous coronary intervention (PCI) has been studied in the past, but recent analyses of national data covering the modern radial, acute coronary syndrome-dominant era are limited. Changing in case-mix, practice, and service provision mean that previously described volume-outcome relationships may no longer be relevant, and a reassessment in contemporary practice is needed. We aim to assess whether operator volume is associated with independently reported 30-day mortality in a contemporary PCI cohort...
March 22, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29559082/the-impact-of-different-background-noises-on-the-production-effect
#14
Yaniv Mama, Leah Fostick, Michal Icht
The presence of background noise has been previously shown to disrupt cognitive performance, especially memory. The amount of interference is derived from the acoustic characteristics of the noise; energetic vs. informational, steady-state vs. fluctuating. However, the literature is inconsistent concerning the effects of different types of noise on long-term memory free recall. In the present study, we tested the impact of different noises on recall of items that were learned under two conditions - silent or aloud reading, a Production Effect (PE) paradigm...
April 2018: Acta Psychologica
https://www.readbyqxmd.com/read/29555873/increasing-socioeconomic-gap-between-the-young-and-old-temporal-trends-in-health-and-overall-deprivation-in-england-by-age-sex-urbanity-and-ethnicity-2004-2015
#15
Evangelos Kontopantelis, Mamas A Mamas, Harm van Marwijk, Iain Buchan, Andrew M Ryan, Tim Doran
BACKGROUND: At a low geographical level, little is known about the associations between population characteristics and deprivation, and their trends, which would be directly affected by the house market, labour pressures and government policies. We describe temporal trends in health and overall deprivation in England by age, sex, urbanity and ethnicity. METHODS: Repeated cross-sectional whole population study for England, 2004-2015, at a low geographical level (average 1500 residents)...
March 19, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29520964/type-2-diabetes-mellitus-and-heart-failure-a-position-statement-from-the-heart-failure-association-of-the-european-society-of-cardiology
#16
REVIEW
Petar M Seferović, Mark C Petrie, Gerasimos S Filippatos, Stefan D Anker, Giuseppe Rosano, Johann Bauersachs, Walter J Paulus, Michel Komajda, Francesco Cosentino, Rudolf A de Boer, Dimitrios Farmakis, Wolfram Doehner, Ekaterini Lambrinou, Yuri Lopatin, Massimo F Piepoli, Michael J Theodorakis, Henrik Wiggers, John Lekakis, Alexandre Mebazaa, Mamas A Mamas, Carsten Tschöpe, Arno W Hoes, Jelena P Seferović, Jennifer Logue, Theresa McDonagh, Jillian P Riley, Ivan Milinković, Marija Polovina, Dirk J van Veldhuisen, Mitja Lainscak, Aldo P Maggioni, Frank Ruschitzka, John J V McMurray
The coexistence of type 2 diabetes mellitus (T2DM) and heart failure (HF), either with reduced (HFrEF) or preserved ejection fraction (HFpEF), is frequent (30-40% of patients) and associated with a higher risk of HF hospitalization, all-cause and cardiovascular (CV) mortality. The most important causes of HF in T2DM are coronary artery disease, arterial hypertension and a direct detrimental effect of T2DM on the myocardium. T2DM is often unrecognized in HF patients, and vice versa, which emphasizes the importance of an active search for both disorders in the clinical practice...
May 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29519382/vascular-access-site-and-outcomes-in-58-870-patients-undergoing-percutaneous-coronary-intervention-with-a-previous-history-of-coronary-bypass-surgery-results-from-the-british-cardiovascular-interventions-society-national-database
#17
Tim Kinnaird, Richard Anderson, Sean Gallagher, James Cockburn, Alex Sirker, Peter Ludman, Mark de Belder, Samuel Copt, James Nolan, Azfar Zaman, Mamas Mamas
OBJECTIVES: Using the British Cardiovascular Intervention Society percutaneous coronary intervention (PCI) database, access site choice and outcomes of patients undergoing PCI with previous coronary artery bypass grafting (CABG) were studied. BACKGROUND: Given the influence of access site on outcomes, use of radial access in PCI-CABG warrants further investigation. METHODS: Data were analyzed from 58,870 PCI-CABG procedures performed between 2005 and 2014...
March 12, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29516189/dft-study-of-geometrical-and-vibrational-features-of-a-3-5-deoxydisugar-monophosphate-ddsmp-dna-model-in-the-presence-of-counterions-and-solvent
#18
Alain Minguirbara, Mama Nsangou
The B3LYP/6-31++G* theoretical level was used to study the influence of various hexahydrated monovalent (Li+ , Na+ , K+ ) and divalent (Mg2+ ) metal counterions in interaction with the charged PO2 - group, on the geometrical and vibrational characteristics of the DNA fragments of 3',5'-dDSMP, represented by four conformers (g+ g+ , g+ t, g- g- and g- t). All complexes were optimized through two solvation models [the explicit model (6H2 O) and the hybrid model (6H2 O/Continuum)]. The results obtained established that, in the hybrid model, counterions (Li+ , Na+ , K+ , Mg2+ ) always remain in the bisector plane of the O1-P-O2 angle...
March 7, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29509764/multimorbidity-and-survival-for-patients-with-acute-myocardial-infarction-in-england-and-wales-latent-class-analysis-of-a-nationwide-population-based-cohort
#19
Marlous Hall, Tatendashe B Dondo, Andrew T Yan, Mamas A Mamas, Adam D Timmis, John E Deanfield, Tomas Jernberg, Harry Hemingway, Keith A A Fox, Chris P Gale
BACKGROUND: There is limited knowledge of the scale and impact of multimorbidity for patients who have had an acute myocardial infarction (AMI). Therefore, this study aimed to determine the extent to which multimorbidity is associated with long-term survival following AMI. METHODS AND FINDINGS: This national observational study included 693,388 patients (median age 70.7 years, 452,896 [65.5%] male) from the Myocardial Ischaemia National Audit Project (England and Wales) who were admitted with AMI between 1 January 2003 and 30 June 2013...
March 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29500812/acute-ocular-pain-during-magnetic-resonance-imaging-due-to-retained-intraocular-metallic-foreign-body-the-role-of-ultrasonography-and-ultrasound-biomicroscopy-in-diagnosis-and-management-of-this-condition
#20
REVIEW
Nikolaos Mamas, Konstantinos Andreanos, Dimitrios Brouzas, Andreas Diagourtas, Andreas Droulias, Ilias Georgalas, Dimitrios Papaconstantinou
PURPOSE: To report the case of a 65-year-old metalworker with no known history of ocular trauma, who suffered from intense ocular pain during magnetic resonance imaging (MRI) of the brain, due to a retained intraocular metallic foreign body (IOFB). CASE REPORT: Meticulous ophthalmological examination was inconclusive. An IOFB was confirmed with X-ray scan, whereas its exact localization was enabled by means of ultrasonography and ultrasound biomicroscopy (UBM). CONCLUSIONS: Despite appropriate screening protocols, MRI-related ocular complications might occur in the presence of a hidden metallic IOFB...
March 2, 2018: Journal of Ultrasound
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