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https://www.readbyqxmd.com/read/28334704/combining-real-time-cold-and-mama-pcr-taqman-techniques-to-detect-and-quantify-r201-gnas-mutations-in-the-mccune-albright-syndrome%C3%A2
#1
Luisa de Sanctis, Ilaria Galliano, Paola Montanari, Patrizia Matarazzo, Daniele Tessaris, Massimiliano Bergallo
BACKGROUND/AIM: The McCune-Albright syndrome (MAS) is a potentially severe disorder hallmarked by fibrous bone dysplasia, café-au-lait skin spots, and endocrine hyperfunction. It is caused by postzygotic activating mutations at the R201 codon of the GNAS gene, leading to a state of somatic mosaicism. Our aim was to improve the mutation detection rate and to quantify the presence of R201 GNAS mutations in different DNA samples from MAS patients. METHODS: Real-time COLD- and MAMA-PCR TaqMan techniques were combined to search for R201 mutations in the DNA of blood or affected tissues from 16 previously molecularly characterized MAS patients, from a further 84 subjects with MAS signs who were R201 negative at RFLP analysis, and from 36 controls...
March 23, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28329972/apport-de-l%C3%A2-irm-dans-l%C3%A2-approche-diagnostique-des-h%C3%A3-mangioblastomes-du-syst%C3%A3-me-nerveux-central
#2
Wael Yacoub, Amel Ben Abdallah, Neila Benzina, Tarek Kammoun, Refaat Nouri, Amira Berriche, Nadia Mama, Nadia Arifa, Jemni Hela
No abstract text is available yet for this article.
March 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28329969/apport-de-l%C3%A2-irm-dans-le-diagnostic-du-syndrome-de-guillain-barr%C3%A3
#3
Bilel Miladi, Amel Ben Abdallah, Amira Berrich, Aymen Merdassi, Nadia Mama, Nadia Arifa, Jemni Hela
No abstract text is available yet for this article.
March 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28301036/factors-associated-with-poor-sleep-quality-in-women-with-cancer
#4
Thalyta Cristina Mansano-Schlosser, Maria Filomena Ceolim
Objectives: to analyze the factors associated with poor sleep quality, its characteristics and components in women with breast cancer prior to surgery for removing the tumor and throughout the follow-up. Method: longitudinal study in a teaching hospital, with a sample of 102 women. The following were used: a questionnaire for sociodemographic and clinical characterization, the Pittsburgh Sleep Quality Index; the Beck Depression Inventory; and the Herth Hope Scale...
March 2, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28291728/variation-in-emergency-percutaneous-coronary-intervention-in-ventilated-patients-in-the-uk-insights-from-a-national-database
#5
John Rawlins, Peter F Ludman, Darragh O'Neil, Mamas A Mamas, Mark de Belder, Simon Redwood, Adrian Banning, Andrew Whittaker, Nick Curzen
AIMS: Pre-procedural ventilation is a marker of high risk in PCI patients. Causes include out-of-hospital cardiac arrest (OHCA) and cardiogenic shock. OHCA occurs in approximately 60,000 patients in the UK per annum. No consensus exists regarding the need/timing of coronary angiography ± revascularization without ST elevation. The aim was to describe the national variation in the rate of emergency PCI in ventilated patients. METHODS AND RESULTS: Using the UK national database for PCI in 2013, we identified all procedures performed as 'emergency' or 'salvage' for whom ventilation had been initiated before the PCI...
February 13, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28291726/change-in-angiogram-derived-management-strategy-of-patients-with-chest-pain-when-some-ffr-data-are-available-how-consistent-is-the-effect
#6
Vinayak Nagaraja, Mamas Mamas, Michael Mahmoudi, Campbell Rogers, Nick Curzen
BACKGROUND: The assessment of patients presenting with angina using invasive angiography alone is imperfect. By contrast, fractional flow reserve (FFR) allows for assessment of lesion-specific ischemia, which is predictive of clinical outcome. A series of studies has demonstrated that the availability of FFR data at the time of diagnostic angiography leads to significant differences in the management of those patients. HYPOTHESIS: The objective of this paper is to describe assess the consistency in the difference in management resulting from an FFR-directed versus and angiogram-directed strategy in appropriate observational and randomized trials...
February 27, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28283032/sustainability-via-active-garden-education-sage-results-from-two-feasibility-pilot-studies
#7
Rebecca E Lee, Nathan H Parker, Erica G Soltero, Tracey A Ledoux, Scherezade K Mama, Lorna McNeill
BACKGROUND: Low physical activity (PA) and fruit and vegetable (F&V) consumption in early childhood are continued public health challenges. This manuscript describes outcomes from two pilot studies for Sustainability via Active Garden Education (SAGE), a program designed to increase PA and F&V consumption among 3 to 5 year old children. METHODS: SAGE was developed using community-based participatory research (CBPR) and delivered to children (N = 89) in early care and education centers (ECEC, N = 6) in two US cities...
March 10, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28280341/a-facile-method-to-prepare-superparamagnetic-iron-oxide-and-hydrophobic-drug-encapsulated-biodegradable-polyurethane-nanoparticles
#8
Kuo-Wei Cheng, Shan-Hui Hsu
Superparamagnetic iron oxide nanoparticles (SPIO NPs) have a wide range of biomedical applications such as in magnetic resonance imaging, targeting, and hyperthermia therapy. Aggregation of SPIO NPs can occur because of the hydrophobic surface and high surface energy of SPIO NPs. Here, we developed a facile method to encapsulate SPIO NPs in amphiphilic biodegradable polymer. Anionic biodegradable polyurethane nanoparticles (PU NPs) with ~35 nm size and different chemistry were prepared by waterborne processes...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28277213/the-effect-of-learning-modality-and-auditory-feedback-on-word-memory-cochlear-implanted-versus-normal-hearing-adults
#9
Riki Taitelbaum-Swead, Michal Icht, Yaniv Mama
BACKGROUND: In recent years, the effect of cognitive abilities on the achievements of cochlear implant (CI) users has been evaluated. Some studies have suggested that gaps between CI users and normal-hearing (NH) peers in cognitive tasks are modality specific, and occur only in auditory tasks. PURPOSE: The present study focused on the effect of learning modality (auditory, visual) and auditory feedback on word memory in young adults who were prelingually deafened and received CIs before the age of 5 yr, and their NH peers...
March 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28264570/quantifying-morphological-features-of-%C3%AE-u3o8-with-image-analysis-for-nuclear-forensics
#10
Adam M Olsen, Bryony Richards, Ian Schwerdt, Sean Heffernan, Robert Lusk, Braxton Smith, Elizabeth Jurrus, Christy Ruggiero, Luther W McDonald
Morphological changes in U3O8 based on calcination temperature have been quantified enabling a morphological feature to serve as a signature of processing history in nuclear forensics. Five separate calcination temperatures were used to synthesize α-U3O8, and each sample was characterized using powder X-ray diffraction (p-XRD) and scanning electron microscopy (SEM). The p-XRD spectra were used to evaluate the purity of the synthesized U-oxide; the morphological analysis for materials (MAMA) software was utilized to quantitatively characterize the particle shape and size as indicated by the SEM images...
March 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28240040/primary-care-doctors-assessment-of-and-preferences-on-their-remuneration
#11
Stefanos Karakolias, Catherine Kastanioti, Mamas Theodorou, Nikolaos Polyzos
Despite numerous studies on primary care doctors' remuneration and their job satisfaction, few of them have quantified their views and preferences on certain types of remuneration. This study aimed at reporting these views and preferences on behalf of Greek doctors employed at public primary care. We applied a 13-item questionnaire to a random sample of 212 doctors at National Health Service health centers and their satellite clinics. The results showed that most doctors deem their salary lower than work produced and lower than that of private sector colleagues...
January 2017: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/28228456/preeclampsia-and-future-cardiovascular-health-a-systematic-review-and-meta-analysis
#12
Pensée Wu, Randula Haththotuwa, Chun Shing Kwok, Aswin Babu, Rafail A Kotronias, Claire Rushton, Azfar Zaman, Anthony A Fryer, Umesh Kadam, Carolyn A Chew-Graham, Mamas A Mamas
BACKGROUND: Preeclampsia is a pregnancy-specific disorder resulting in hypertension and multiorgan dysfunction. There is growing evidence that these effects persist after pregnancy. We aimed to systematically evaluate and quantify the evidence on the relationship between preeclampsia and the future risk of cardiovascular diseases. METHODS AND RESULTS: We studied the future risk of heart failure, coronary heart disease, composite cardiovascular disease, death because of coronary heart or cardiovascular disease, stroke, and stroke death after preeclampsia...
February 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28224933/inadequacy-of-existing-clinical-prediction-models-for-predicting-mortality-after-transcatheter-aortic-valve-implantation
#13
Glen P Martin, Matthew Sperrin, Peter F Ludman, Mark A de Belder, Chris P Gale, William D Toff, Neil E Moat, Uday Trivedi, Iain Buchan, Mamas A Mamas
BACKGROUND: The performance of emerging transcatheter aortic valve implantation (TAVI) clinical prediction models (CPMs) in national TAVI cohorts distinct from those where they have been derived is unknown. This study aimed to investigate the performance of the German Aortic Valve, FRANCE-2, OBSERVANT and American College of Cardiology (ACC) TAVI CPMs compared with the performance of historic cardiac CPMs such as the EuroSCORE and STS-PROM, in a large national TAVI registry. METHODS: The calibration and discrimination of each CPM were analyzed in 6676 patients from the UK TAVI registry, as a whole cohort and across several subgroups...
February 2017: American Heart Journal
https://www.readbyqxmd.com/read/28214795/pre-implantation-balloon-aortic-valvuloplasty-and-clinical-outcomes-following-transcatheter-aortic-valve-implantation-a-propensity-score-analysis-of-the-uk-registry
#14
Glen P Martin, Matthew Sperrin, Rodrigo Bagur, Mark A de Belder, Iain Buchan, Mark Gunning, Peter F Ludman, Mamas A Mamas
BACKGROUND: Aortic valve predilation with balloon aortic valvuloplasty (BAV) is recommended before transcatheter aortic valve implantation (TAVI), despite limited data around the requirement of this preprocedural step and the potential risks of embolization. This study aimed to investigate the trends in practice and associations of BAV on short-term outcomes in the UK TAVI registry. METHODS AND RESULTS: Eleven clinical endpoints were investigated, including 30-day mortality, myocardial infarction, aortic regurgitation, valve dysfunction, and composite early safety...
February 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28198953/predictors-of-hope-among-women-with-breast-cancer-during-chemotherapy
#15
Alessandra Cristina Sartore Balsanelli, Sonia Aurora Alves Grossi
OBJECTIVE: Identifying the predictors of hope in patients with breast cancer during chemotherapy treatment. METHOD: A prospective longitudinal study. The sample was composed of 122 women who responded to the instruments of hope, anxiety and depression, coping, fatigue, religiosity and self-esteem in the first and last cycle of chemotherapy. These variables were used in adjusting the logistic regression model that characterized multivariate statistics, allowing identification of predictor variables...
November 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28198913/body-composition-in-patients-with-crohn-s-disease-and-ulcerative-colitis
#16
Ivi Ribeiro Back, Sonia Silva Marcon, Natalia Moreno Gaino, Daniela Salate Biagioni Vulcano, Mariana de Souza Dorna, Ligia Yukie Sassaki
BACKGROUND: The nutritional status of individuals with inflammatory bowel diseases is directly related to the severity of the disease and is associated with poor prognosis and the deterioration of immune competence. OBJECTIVE: To assess the nutritional status and the body composition of outpatients with inflammatory bowel diseases. METHODS: A cross-sectional study was conducted with clinical and nutritional assessment of patients with Crohn's disease and ulcerative colitis...
February 13, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28196898/increased-radial-access-is-not-associated-with-worse-femoral-outcomes-for-percutaneous-coronary-intervention-in-the-united-kingdom
#17
William Hulme, Matthew Sperrin, Evangelos Kontopantelis, Karim Ratib, Peter Ludman, Alex Sirker, Tim Kinnaird, Nick Curzen, Chun Shing Kwok, Mark De Belder, James Nolan, Mamas A Mamas
BACKGROUND: The radial artery is increasingly adopted as the primary access site for cardiac catheterization because of patient preference, lower bleeding rates, cost effectiveness, and reduced risk of mortality in high-risk patient groups. Concerns have been expressed that operators/centers have become increasingly unfamiliar with transfemoral access. The aim of this study was to assess whether a change in access site practice toward transradial access nationally has led to worse outcomes in percutaneous coronary intervention procedures performed through the transfemoral access approach...
February 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28163831/endothelial-progenitor-cells-exploring-the-pleiotropic-effects-of-statins
#18
REVIEW
Kully Sandhu, Mamas Mamas, Robert Butler
Statins have become a cornerstone of risk modification for ischaemic heart disease patients. A number of studies have shown that they are effective and safe. However studies have observed an early benefit in terms of a reduction in recurrent infarct and or death after a myocardial infarction, prior to any significant change in lipid profile. Therefore, pleiotropic mechanisms, other than lowering lipid profile alone, must account for this effect. One such proposed pleiotropic mechanism is the ability of statins to augment both number and function of endothelial progenitor cells...
January 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28160034/the-effects-of-synthetic-cannabinoids-on-executive-function
#19
K Cohen, M Kapitány-Fövény, Y Mama, M Arieli, P Rosca, Z Demetrovics, A Weinstein
BACKGROUND AND AIMS: There is a growing use of novel psychoactive substances (NPSs) including synthetic cannabinoids. Synthetic cannabinoid products have effects similar to those of natural cannabis but the new synthetic cannabinoids are more potent and dangerous and their use has resulted in various adverse effects. The purpose of the study was to assess whether persistent use of synthetic cannabinoids is associating with impairments of executive function in chronic users. METHODS: A total of 38 synthetic cannabinoids users, 43 recreational cannabis users, and 41 non-user subjects were studied in two centers in Hungary and Israel...
February 3, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28154542/the-modified-abbreviated-math-anxiety-scale-a-valid-and-reliable-instrument-for-use-with-children
#20
Emma Carey, Francesca Hill, Amy Devine, Dénes Szűcs
Mathematics anxiety (MA) can be observed in children from primary school age into the teenage years and adulthood, but many MA rating scales are only suitable for use with adults or older adolescents. We have adapted one such rating scale, the Abbreviated Math Anxiety Scale (AMAS), to be used with British children aged 8-13. In this study, we assess the scale's reliability, factor structure, and divergent validity. The modified AMAS (mAMAS) was administered to a very large (n = 1746) cohort of British children and adolescents...
2017: Frontiers in Psychology
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