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https://www.readbyqxmd.com/read/28927187/impact-of-co-morbid-burden-on-mortality-in-patients-with-coronary-heart-disease-heart-failure-and-cerebrovascular-accident-a-systematic-review-and-meta-analysis
#1
Muhammad Rashid, Chun Shing Kwok, Chris P Gale, Patrick Doherty, Ivan Olier, Matthew Sperrin, Evangelos Kontopantelis, George Peat, Mamas A Mamas
Aims: We sought to investigate the prognostic impact of co-morbid burden as defined by the Charlson Co-morbidity Index (CCI) in patients with a range of prevalent cardiovascular diseases. Methods and results: We searched MEDLINE and EMBASE to identify studies that evaluated the impact of CCI on mortality in patients with cardiovascular disease. A random-effects meta-analysis was undertaken to evaluate the impact of CCI on mortality in patients with coronary heart disease (CHD), heart failure (HF), and cerebrovascular accident (CVA)...
January 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28923695/the-effect-of-pre-procedure-sublingual-nitroglycerin-on-radial-artery-diameter-and-allen-s-test-outcome-relevance-to-transradial-catheterization
#2
Aun-Yeong Chong, Ted Lo, Sudhakar George, Karim Ratib, Mamas Mamas, James Nolan
BACKGROUND: The radial artery is increasingly used for cardiac procedures, but is a relatively small vessel that is prone to spasm when instrumented. Intra-arterial nitroglycerine has been shown to reduce radial spasm but first requires arterial access. We investigated the effect of pre-procedure sublingual nitroglycerin (NTG) on the diameter of the radial artery in a large cohort of patients. METHODS: 305 subjects underwent ultrasound measurement of their radial and ulnar arteries in both arms before and after the administration of 800μg of sublingual NTG...
July 29, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28917753/nuclear-forensics-investigation-of-morphological-signatures-in-the-thermal-decomposition-of-uranyl-peroxide
#3
Ian J Schwerdt, Adam Olsen, Robert Lusk, Sean Heffernan, Michael Klosterman, Bryce Collins, Sean Martinson, Trenton Kirkham, Luther W McDonald
The analytical techniques typically utilized in a nuclear forensic investigation often provide limited information regarding the process history and production conditions of interdicted nuclear material. In this study, scanning electron microscopy (SEM) analysis of the surface morphology of amorphous-UO3 samples calcined at 250, 300, 350, 400, and 450°C from uranyl peroxide was performed to determine if the morphology was indicative of the synthesis route and thermal history for the samples. Thermogravimetic analysis-mass spectrometry (TGA-MS) and differential scanning calorimetry (DSC) were used to correlate transitions in the calcined material to morphological transformations...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28916604/coronary-perforation-complicating-percutaneous-coronary-intervention-in-patients-with-a-history-of-coronary-artery-bypass-surgery-an-analysis-of-309-perforation-cases-from-the-british-cardiovascular-intervention-society-database
#4
Tim Kinnaird, Richard Anderson, Nick Ossei-Gerning, James Cockburn, Alex Sirker, Peter Ludman, Mark de Belder, Thomas W Johnson, Samuel Copt, Azfar Zaman, Mamas A Mamas
BACKGROUND: The evidence base for coronary perforation (CP) occurring during percutaneous coronary intervention in patients with a history of coronary artery bypass surgery (PCI-CABG) is limited and the long-term effects unclear. Using a national PCI database, the incidence, predictors, and outcomes of CP during PCI-CABG were defined. METHODS AND RESULTS: Data were analyzed on all PCI-CABG procedures performed in England and Wales between 2005 and 2013. Multivariate logistic regressions and propensity scores were used to identify predictors of CP and its association with outcomes...
September 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28885419/competency-based-objectives-in-global-underserved-women-s-health-for-medical-trainees
#5
Chi Chiung Grace Chen, Anne Dougherty, Sara Whetstone, Saifuddin T Mama, Margaret Larkins-Pettigrew, Susan P Raine, Amy M Autry
The Association of Professors of Gynecology and Obstetrics Committee on Global Health developed an inclusive definition of global women's health and competency-based objectives that reflected work internationally, as well as with U.S. vulnerable and underserved populations, such as refugee and immigrant populations or those who would otherwise have compromised access to health care. The knowledge, skill, and attitude-based competencies required to fulfill each learning objective were mapped to the Accreditation Council for Graduate Medical Education Outcomes Project's educational domains and the Consortium of Universities for Global Health competency domains...
September 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28868307/atlanto-axial-langerhans-cell-histiocytosis-in-a-child-presented-as-torticollis
#6
Miniar Tfifha, Mehdi Gaha, Nadia Mama, Mohamed Taher Yacoubi, Saoussen Abroug, Hela Jemni
Langerhans cell histiocytosis (LCH) is a rare condition mostly seen in children and adolescents. Eosinophilic granuloma (EG) is one of its three clinical entities and is considered as a benign osteolytic lesion. Many reports of patients with spine histiocytosis are well documented in the literature but it is not the case of atlantoaxial localization. We report here a new observation of atlantoaxial LCH in a 4-year-old boy revealed by persistent torticollis. He was successfully treated with systemic chemotherapy and surgery...
August 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28867764/fluorescent-polymer-incorporating-triazolyl-coumarin-units-for-cu-2-detection-via-planarization-of-ict-based-fluorophore
#7
Jean Marie Vianney Ngororabanga, Jacolien Du Plessis, Neliswa Mama
A novel fluorescent polymer with pendant triazolyl coumarin units was synthesized through radical polymerization. The polymer showed reasonable sensitivity and selectivity towards Cu(2+) in acetonitrile in comparison to other tested metal ions with a significant quenching effect on fluorescence and blue shifting in the range of 20 nm. The blue shift was assigned to the conformation changes of the diethylamino group from the coumarin moiety which led to planarization of the triazolyl coumarin units. The possible binding modes for Cu(2+) towards the polymer were determined through the comparison of the emission responses of the polymer, starting vinyl monomer and reference compound, and the triazole ring was identified as one of the possible binding sites for Cu(2+)...
August 30, 2017: Sensors
https://www.readbyqxmd.com/read/28863469/parasites-causing-cerebral-falciparum-malaria-bind-multiple-endothelial-receptors-and-express-epcr-and-icam-1-binding-pfemp1
#8
Nicaise Tuikue Ndam, Azizath Moussiliou, Thomas Lavstsen, Claire Kamaliddin, Anja T R Jensen, Atikatou Mama, Rachida Tahar, Christian W Wang, Jakob S Jespersen, Jules M Alao, Benoit Gamain, Thor G Theander, Philippe Deloron
Background: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates the binding and accumulation of infected erythrocytes (IE) to blood vessels and tissues. Specific interactions have been described between PfEMP1 and human endothelial proteins CD36, intercellular adhesion molecule-1 (ICAM-1), and endothelial protein C receptor (EPCR); however, cytoadhesion patterns typical for pediatric malaria syndromes and the associated PfEMP1 members are still undefined. Methods: In a cohort of 94 hospitalized children with malaria, we characterized the binding properties of IE collected on admission, and var gene transcription using quantitative polymerase chain reaction...
June 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28816589/acculturation-influences-postpartum-eating-activity-and-weight-retention-in-low-income-hispanic-women
#9
Chantel L Martin, Deborah F Tate, Andrew Schaffner, Anna Brannen, Karen Erickson Hatley, Molly Diamond, Karen Munoz-Christian, Jeremy Pomeroy, Teresa Sanchez, Adrian Mercado, Todd Hagobian, Suzanne Phelan
BACKGROUND: Low-income Hispanic women experience elevated rates of high postpartum weight retention (PPWR), which is an independent risk factor for lifetime obesity. Sociocultural factors might play an important role among Hispanic women; however, very few studies have examined this association. OBJECTIVE: The purpose of our study was to examine the associations between acculturation and maternal diet, physical activity, and PPWR. DESIGN: This is a cross-sectional study of baseline data from 282 Hispanic women participating in the FitMoms/Mamás Activas study, a randomized controlled trial examining the impact of primarily an internet-based weight control program, in reducing PPWR among low-income women...
August 17, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28808427/public-engagement-in-setting-healthcare-priorities-a-ranking-exercise-in-cyprus
#10
Antonis Farmakas, Mamas Theodorou, Petros Galanis, Georgios Karayiannis, Stefanos Ghobrial, Nikos Polyzos, Evridiki Papastavrou, Eirini Agapidaki, Kyriakos Souliotis
BACKGROUND: In countries such as Cyprus the financial crisis and the recession have severely affected the funding and priority setting of the health care system. There is evidence highlighting the importance of population' preferences in designing priorities for health care settings. Although public preferences have been thorough analysed in many countries, there is a research gap in terms of simultaneously investigating the relative importance and the weight of differing and competing criteria for determining healthcare priority settings...
2017: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/28780035/dialysis-following-transcatheter-aortic%C3%A2-valve-implantation-risk%C3%A2-factors%C3%A2-and%C3%A2-outcomes-an-analysis-from-the-uk-tavi-registry-transcatheter%C3%A2-aortic%C3%A2-valve-implantation-registry
#11
Charles J Ferro, Jonathan P Law, Sagar N Doshi, Mark de Belder, Neil Moat, Mamas Mamas, David Hildick-Smith, Peter Ludman, Jonathan N Townend
OBJECTIVES: The study sought to determine the risk factors for post-transcatheter aortic valve replacement (TAVR) dialysis and to determine the impact of pre-TAVR or post-TAVR dialysis on mortality. BACKGROUND: TAVR is now established as an alternative treatment to surgical aortic valve replacement. Data examining the impact of dialysis on outcomes after TAVR are lacking. METHODS: The UK TAVI (Transcatheter Aortic Valve Implantation) Registry was established to report outcomes on all TAVR procedures performed within the United Kingdom (2007 to 2014)...
July 27, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28757814/a-dft-study-of-structural-and-bonding-properties-of-complexes-obtained-from-first-row-transition-metal-chelation-by-3-alkyl-4-phenylacetylamino-4-5-dihydro-1h-1-2-4-triazol-5-one-and-its-derivatives
#12
Hubert Jean Nono, Désiré Bikélé Mama, Julius Numbonui Ghogomu, Elie Younang
Density functional calculations were used to explore the complexation of 3-alkyl-4-phenylacetylamino-4,5-dihydro-1h-1,2,4-triazol-5-one (ADPHT) derivatives by first-row transition metal cations. Neutral ADPHT ligand and mono deprotonated ligands have been used. Geometry optimizations have been performed in gas-phase and solution-phase (water, benzene, and N,N-dimethylformamide (DMF)) with B3LYP/Mixed I (LanL2DZ for metal atom and 6-31+G(d,p) for C, N, O, and H atoms) and with B3LYP/Mixed II (6-31G(d) for metal atom and 6-31+G(d,p) for C, N, O, and H atoms) especially in the gas-phase...
2017: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/28752909/light-irradiation-helps-magnetotactic-bacteria-eliminate-intracellular-reactive-oxygen-species
#13
Kefeng Li, Pingping Wang, Chuanfang Chen, Changyou Chen, Lulu Li, Tao Song
Magnetotactic bacteria (MTB) demonstrate photoresponse. However, little is known about the biological significance of this behaviour. Magnetosomes exhibit peroxidase-like activity and can scavenge reactive oxygen species (ROS). Magnetosomes extracted from the Magnetospirillum magneticum strain AMB-1 show enhanced peroxidase-like activity under illumination. The present study investigated the effects of light irradiation on nonmagnetic (without magnetosomes) and magnetic (with magnetosomes) AMB-1 cells. Results showed that light irradiation did not affect the growth of nonmagnetic and magnetic cells but significantly increased magnetosome synthesis and reduced intracellular ROS level in magnetic cells...
July 28, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28734855/effects-of-constant-rate-infusions-of-dexmedetomidine-or-mk-467-on-the-minimum-alveolar-concentration-of-sevoflurane-in-dogs
#14
Rachel C Hector, Marlis L Rezende, Khursheed R Mama, Eugene P Steffey, Heather K Knych, Ann M Hess, Juhana M Honkavaara, Marja R Raekallio, Outi M Vainio
OBJECTIVE: To determine the effects of low and high dose infusions of dexmedetomidine and a peripheral α2-adrenoceptor antagonist, MK-467, on sevoflurane minimum alveolar concentration (MAC) in dogs. STUDY DESIGN: Crossover experimental study. ANIMALS: Six healthy, adult Beagle dogs weighing 12.6±0.9 kg (mean±standard deviation). METHODS: Dogs were anesthetized with sevoflurane in oxygen. After a 60-minute instrumentation and equilibration period, the MAC of sevoflurane was determined in triplicate using the tail clamp technique...
March 4, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28728745/early-readmissions-after-acute-myocardial-infarction
#15
Chun Shing Kwok, Chun Wai Wong, Hannah Shufflebotham, Luke Brindley, Tamseel Fatima, Adrian Shufflebotham, Diane Barker, Ashish Pawala, Grant Heatlie, Mamas A Mamas
This study aims to evaluate the rate, predictors, and causes of 30-day readmissions in a single tertiary hospital in the United Kingdom. We conducted a retrospective study of all patients admitted between 2012 and 2014 with a diagnosis of acute myocardial infarction, who were in the Myocardial Infarction National Audit Project register. Data on patient demographics, comorbidities, care received, and in-hospital mortality were collected. Rates of 30-day readmission and causes of readmission were evaluated. Univariate and multiple logistic regressions were used to identify predictors of all-cause, cardiac, and noncardiac readmission...
September 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28720767/assessment-of-the-occurrence-spatiotemporal-variations-and-geoaccumulation-of-fifty-two-inorganic-elements-in-sewage-sludge-a-sludge-management-revisit
#16
Fidèle Suanon, Qian Sun, Xiaoyong Yang, Qiaoqiao Chi, Sikandar I Mulla, Daouda Mama, Chang-Ping Yu
The limited information about the sludge quality has made its management a top environmental challenge. In the present study, occurrence and the spatiotemporal variations of 52 inorganic elements were investigated in the sludge samples from three wastewater treatment plants (WWTPs) in Xiamen city, China. The results showed, the occurrence of 49 elements with the concentrations in the range of >125-53500 mg kg(-1) dry sludge (DS) for commonly used industrial metals, 1.22-14.0 mg kg(-1) DS for precious metals, and 1...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28705529/atrial-fibrillation-a-riddle-wrapped-in-a-mystery-inside-an-enigma
#17
Claire Alexandra Lawson, Mamas Andreas Mamas
No abstract text is available yet for this article.
July 10, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28691534/relative-survival-and-excess-mortality-following-primary-percutaneous-coronary-intervention-for-st-elevation-myocardial-infarction
#18
Richard A Brogan, Oras Alabas, Sami Almudarra, Marlous Hall, Tatendashe B Dondo, Mamas A Mamas, Paul D Baxter, Phillip D Batin, Nick Curzen, Mark de Belder, Peter F Ludman, Chris P Gale
BACKGROUND: High survival rates are commonly reported following primary percutaneous coronary intervention for ST-elevation myocardial infarction, with most contemporary studies reporting overall survival. AIMS: The aim of this study was to describe survival following primary percutaneous coronary intervention for ST-elevation myocardial infarction corrected for non-cardiovascular deaths by reporting relative survival and investigate clinically significant factors associated with poor long-term outcomes...
July 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28687562/efficacy-and-safety-of-the-subcutaneous-implantable-cardioverter-defibrillator-a-systematic-review
#19
REVIEW
Colin Dominic Chue, Chun Shing Kwok, Chun Wai Wong, Ashish Patwala, Diane Barker, Amir Zaidi, Mamas A Mamas, Colin Cunnington, Fozia Z Ahmed
BACKGROUND: Subcutaneous implantable cardioverter defibrillators (S-ICDs) are considered an alternative to conventional transvenous ICDs (TV-ICDs) in patients not requiring pacing. METHODS: We searched MEDLINE and EMBASE for studies evaluating efficacy and safety outcomes in S-ICD patients. Outcomes were pooled across studies. RESULTS: Sixteen studies were included with 5380 participants (mean age range 33-56 years). Short-term follow-up data were available for 1670 subjects...
September 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28683933/the-relationship-of-body-mass-index-to-percutaneous-coronary-intervention-outcomes-does-the-obesity-paradox-exist-in-contemporary-percutaneous%C3%A2-coronary-intervention-cohorts-insights-from-the%C3%A2-british-cardiovascular-intervention-society-registry
#20
Eric W Holroyd, Alex Sirker, Chun Shing Kwok, Evangelos Kontopantelis, Peter F Ludman, Mark A De Belder, Robert Butler, James Cotton, Azfar Zaman, Mamas A Mamas
OBJECTIVES: The aims of this study were to examine the relationship between body mass index (BMI) and clinical outcomes following percutaneous coronary intervention (PCI) and to determine the relevance of different clinical presentations requiring PCI to this relationship. BACKGROUND: Obesity is a growing problem, and studies have reported a protective effect from obesity compared with normal BMI for adverse outcomes after PCI. METHODS: Between 2005 and 2013, 345,192 participants were included...
July 10, 2017: JACC. Cardiovascular Interventions
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