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Athletic performance, gene

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https://www.readbyqxmd.com/read/27928199/association-of-anxiety-related-polymorphisms-with-sports-performance-in-chilean-long-distance-triathletes-a-pilot-study
#1
Jorge A Sanhueza, Tomás Zambrano, Carlos Bahamondes-Avila, Luis A Salazar
Different factors affecting athletic performance are well established: intensity and type of training, anthropometric characteristics as well as an important psychological component. However, the contribution of the genetic background has been less investigated. The aim of the present study was to investigate the influence of polymorphisms within genes associated with stress and anxiety (5HTT, CRH2R, ACE, NK1R, 5HT1AR and CRF-BP) on the physical capability and sports performance in triathletes. One hundred and ninety two (192) unrelated Chilean triathletes who participated in the 2014 70...
December 2016: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/27899345/ethics-of-genetic-testing-and-research-in-sport-a-position-statement-from-the-australian-institute-of-sport
#2
Nicole Vlahovich, Peter A Fricker, Matthew A Brown, David Hughes
As Australia's peak high-performance sport agency, the Australian Institute of Sport (AIS) has developed this position statement to address the implications of recent advances in the field of genetics and the ramifications for the health and well-being of athletes. Genetic testing has proven of value in the practice of clinical medicine. There are, however, currently no scientific grounds for the use of genetic testing for athletic performance improvement, sport selection or talent identification. Athletes and coaches should be discouraged from using direct-to-consumer genetic testing because of its lack of validation and replicability and the lack of involvement of a medical practitioner in the process...
November 29, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27895662/muscle-enriched-micrornas-isolated-from-whole-blood-are-regulated-by-exercise-and-are-potential-biomarkers-of-cardiorespiratory-fitness
#3
Joshua Denham, Priscilla R Prestes
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression post-transcriptionally. Evidence indicating miRNAs influence exercise-induced health and performance adaptations is mounting. Circulating miRNAs are responsible for intercellular communication and could serve as biomarkers for disease and exercise-related traits. Such biomarkers would contribute to exercise screening, monitoring, and the development of personalized exercise prescription. Accordingly, we investigated the impact of long-term strenuous aerobic exercise training and a single bout of maximal aerobic exercise on five muscle-enriched miRNAs implicated in exercise adaptations (miR-1, miR-133a, miR-181a, miR-486, and miR-494)...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27782053/circulating-micrornas-as-potential-biomarkers-of-exercise-response
#4
REVIEW
Mája Polakovičová, Peter Musil, Eugen Laczo, Dušan Hamar, Ján Kyselovič
Systematic physical activity increases physical fitness and exercise capacity that lead to the improvement of health status and athletic performance. Considerable effort is devoted to identifying new biomarkers capable of evaluating exercise performance capacity and progress in training, early detection of overtraining, and monitoring health-related adaptation changes. Recent advances in OMICS technologies have opened new opportunities in the detection of genetic, epigenetic and transcriptomic biomarkers. Very promising are mainly small non-coding microRNAs (miRNAs)...
October 5, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27747845/actn3-r577x-polymorphism-is-not-associated-with-team-sport-athletic-status-in-italians
#5
Myosotis Massidda, Valeria Bachis, Laura Corrias, Francesco Piras, Marco Scorcu, Claudia Culigioni, Daniele Masala, Carla M Calò
BACKGROUND: The ACTN3 gene may influence performance in team sports, in which sprint action and high-speed movements, regulated by the anaerobic energy system, are crucial to the ultimate success of a match. The aim of this study was to determine the association between the ACTN3 R577X (rs1815739) polymorphism and elite team sport athletic status in Italian male athletes. METHODS: We compared the genotype and allele frequency of the ACTN3 R577X polymorphism between team sport athletes (n = 75), endurance athletes (n = 40), sprint/power athletes (n = 64), and non-athletic healthy controls (n = 192) from Italy...
December 2015: Sports Medicine—Open
https://www.readbyqxmd.com/read/27736250/olympic-genes-on-the-podium
#6
Fabian Sanchis-Gomar, Helios Pareja-Galeano, Jose A Rodriguez-Marroyo, Jos J de Koning, Alejandro Lucia, Carl Foster
Despite some advances, it remains largely unknown how the millions of variations in the human genome influence athletic performance (especially in endurance events), and no single genetic test can really predict sports talent. However, there is experimental evidence from animal research that selecting for even a simple characteristic such as running ability can produce comparatively large and rapid changes in performance. That such selection has not been specifically documented in humans is more evidence of the limits of physiology-archeology than of the unlikelihood of selection for physical abilities...
October 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27735833/effects-of-almond-and-olive-oil-based-docosahexaenoic-and-vitamin-e-enriched-beverage-dietary-supplementation-on-inflammation-associated-to-exercise-and-age
#7
Xavier Capó, Miquel Martorell, Antoni Sureda, Joan Riera, Franchek Drobnic, Josep Antoni Tur, Antoni Pons
n-3-polyunsaturated fatty acids and polyphenols are potential key factors for the treatment and prevention of chronic inflammation associated to ageing and non-communicable diseases. The aim was to analyse effects of an almond and olive oil beverage enriched with α-tocopherol and docosahexaenoic, exercise and age on inflammatory plasma markers, and immune gene expression in peripheral blood mononuclear cells (PBMCs). Five young and five senior athletes who were supplemented for five weeks with a functional beverage performed a stress test under controlled conditions before and after beverage supplementation...
October 9, 2016: Nutrients
https://www.readbyqxmd.com/read/27693050/circulating-mirna-as-fine-regulators-of-the-physiological-responses-to-physical-activity-pre-analytical-warnings-for-a-novel-class-of-biomarkers
#8
REVIEW
Giovanni Lombardi, Silvia Perego, Veronica Sansoni, Giuseppe Banfi
MicroRNAs are endogenous non-coding RNAs that post-transcriptionally regulate gene expression by specifically binding the target mRNA and by consequently inducing its degradation. miRNAs can be released into the circulation where they remain stable and they can be measured. Their changes reflect individual biologic adaptation to exposures to specific environmental conditions. As such, measurement of circulating microRNAs represents an opportunity to evaluate biologic changes associated with interventions such as exercise and diet...
December 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27691998/characterisation-of-equine-satellite-cell-transcriptomic-profile-response-to-%C3%AE-hydroxy-%C3%AE-methylbutyrate-hmb
#9
Katarzyna A Szcześniak, Anna Ciecierska, Piotr Ostaszewski, Tomasz Sadkowski
β-Hydroxy-β-methylbutyrate (HMB) is a popular ergogenic aid used by human athletes and as a supplement to sport horses, because of its ability to aid muscle recovery, improve performance and body composition. Recent findings suggest that HMB may stimulate satellite cells and affect expressions of genes regulating skeletal muscle cell growth. Despite the scientific data showing benefits of HMB supplementation in horses, no previous study has explained the mechanism of action of HMB in this species. The aim of this study was to reveal the molecular background of HMB action on equine skeletal muscle by investigating the transcriptomic profile changes induced by HMB in equine satellite cells in vitro...
October 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27601773/association-analysis-of-ace-actn3-and-ppargc1a-gene-polymorphisms-in-two-cohorts-of-european-strength-and-power-athletes
#10
V Gineviciene, A Jakaitiene, M O Aksenov, A V Aksenova, A M Druzhevskaya, I V Astratenkova, E S Egorova, L J Gabdrakhmanova, L Tubelis, V Kucinskas, A Utkus
The performance of professional strength and power athletes is influenced, at least partly, by genetic components. The main aim of this study was to investigate individually and in combination the association of ACE (I/D), ACTN3 (R577X) and PPARGC1A (Gly482Ser) gene polymorphisms with strength/power-oriented athletes' status in two cohorts of European athletes. A cohort of European Caucasians from Russia and Lithuania (161 athletes: by groups - weightlifters (87), powerlifters (60), throwers (14); by elite status - 'elite' (104), 'sub-elite' (57); and 1,202 controls) were genotyped for ACE, ACTN3 and PPARGC1A polymorphisms...
September 2016: Biology of Sport
https://www.readbyqxmd.com/read/27508152/characterization-of-the-metabolic-effect-of-%C3%AE-alanine-on-markers-of-oxidative-metabolism-and-mitochondrial-biogenesis-in-skeletal-muscle
#11
Jamie K Schnuck, Kyle L Sunderland, Matthew R Kuennen, Roger A Vaughan
PURPOSE: β-alanine is a common component of numerous sports supplements purported to improve athletic performance through enhanced carnosine biosynthesis and related intracellular buffering. To date, the effects of β-alanine on oxidative metabolism remain largely unexplored. This work investigated the effects of β-alanine on the expression of proteins which regulate cellular energetics. METHODS: C2C12 myocytes were cultured and differentiated under standard conditions followed by treatment with either β-alanine or isonitrogenous non-metabolizable control D-alanine at 800μM for 24 hours...
June 2016: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/27506998/concurrent-exercise-training-do-opposites-distract
#12
Vernon G Coffey, John A Hawley
Specificity is a core principle of exercise training to promote the desired adaptations for maximising athletic performance. The principle of specificity of adaptation is underpinned by the volume, intensity, frequency and mode of contractile activity and is most evident when contrasting the divergent phenotypes that result after undertaking either prolonged endurance or resistance training. The molecular profiles that generate the adaptive response to different exercise modes have undergone intense scientific scrutiny...
August 10, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27464417/polymorphism-of-the-igf-i-system-and-sports-performance
#13
REVIEW
Sigal Ben-Zaken, Yoav Meckel, Dan Nemet, Nitzan Dror, Alon Eliakim
The potential use genetic polymorphism, and in particularly polymorphism of hormone genes, as tool to predict athletic performance is currently very challenging. Recent studies suggest that single nucleotide polymorphisms in IGF-I and myostatin may be beneficial for endurance and short distance running, and may even be associated with elite performance. Polymorphism in IGF-I receptor may differentiate between the two edges of the endurance-power athletic performance running spectrum suggesting beneficial effects for endurance and prevent from success in power events...
June 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/27448144/identification-of-genetic-markers-for-skill-and-athleticism-in-sub-elite-australian-football-players-a-pilot-study
#14
Ysabel Jacob, Ashley Cripps, Tess Evans, Paola T Chivers, Christopher Joyce, Ryan S Anderton
BACKGROUND: Natural genetic variation contributes towards athletic performance in various strength/power and endurance based sports. To date, no studies have explored the genetic predisposition towards skill and athletic performance in Australian Football (AF) players. METHODS: The present pilot study recruited 30 sub-elite AF players who completed tests of endurance, power and technical skill. Specific polymorphisms in nine genes were screened, and assessed for a possible association with athletic and skill traits...
July 22, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27442335/actn3-r577x-gene-variant-is-associated-with-muscle-related-phenotypes-in-elite-chinese-sprint-power-athletes
#15
Ruoyu Yang, Xunzhang Shen, Yubin Wang, Sarah Voisin, Guang Cai, Yongnan Fu, Wangyu Xu, Nir Eynon, David J Bishop, Xu Yan
The ACTN3 R577X polymorphism (rs1815739) has been shown to influence athletic performance. The aim of the current study was to investigate the prevalence of this polymorphism in elite Chinese track and field athletes, and to explore its effects on athletes' level of competition and lower-extremity power. We compared the ACTN3 R577X genotypes and allele frequencies in 59 elite sprint/power athletes, 44 elite endurance athletes, and 50 healthy controls from Chinese Han origin. We then subcategorized the athletes into international-level and national-level, and investigated the effects of ACTN3 genotype on lower-extremity power...
July 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27428007/an-update-on-the-relationship-between-statins-and-physical-activity
#16
Gregory A Panza, Beth A Taylor, Paul D Thompson
PURPOSE OF REVIEW: This review examined studies published within the last 16 months that investigated the relationship between statins and physical activity. RECENT FINDINGS: These recent studies suggest that statins do not adversely affect cardiorespiratory fitness, muscle strength, athletic performance, or physical activity adherence. One recent study comparing patients with statin-associated myalgia and nonstatin-using controls did report that statins are associated with a slowing of time to peak power output, increased abdominal adiposity, and insulin resistance...
September 2016: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/27361254/association-between-candidate-performance-related-gene-polymorphisms-and-strength-in-iranian-elite-athletes-2618-board-141-june-3-9-30-am-11-00-am
#17
Rana Fayazmilani, Neda Khaledi, Sareh Arjmand
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27294501/genetic-variation-and-exercise-induced-muscle-damage-implications-for-athletic-performance-injury-and-ageing
#18
REVIEW
Philipp Baumert, Mark J Lake, Claire E Stewart, Barry Drust, Robert M Erskine
Prolonged unaccustomed exercise involving muscle lengthening (eccentric) actions can result in ultrastructural muscle disruption, impaired excitation-contraction coupling, inflammation and muscle protein degradation. This process is associated with delayed onset muscle soreness and is referred to as exercise-induced muscle damage. Although a certain amount of muscle damage may be necessary for adaptation to occur, excessive damage or inadequate recovery from exercise-induced muscle damage can increase injury risk, particularly in older individuals, who experience more damage and require longer to recover from muscle damaging exercise than younger adults...
September 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27294385/the-effect-of-a-high-protein-diet-and-exercise-on-cardiac-aqp7-and-glut4-gene-expression
#19
Orkide Palabiyik, Aziz Karaca, Ebru Taştekin, Bilge Eren Yamasan, Burcu Tokuç, Tammam Sipahi, Selma Arzu Vardar
High-protein (HP) diets are commonly consumed by athletes despite their potential health hazard, which is postulated to enforce a negative effect on bone and renal health. However, its effects on heart have not been known yet. Aquaporin-7 (AQP7) is an aquaglyceroporin that facilitates glycerol and water transport. Glycerol is an important cardiac energy production substrate, especially during exercise, in conjunction with fatty acids and glucose. Glucose transporter 4 (GLUT4) is an insulin-sensitive glucose transporter in heart...
October 2016: Biochemical Genetics
https://www.readbyqxmd.com/read/27274666/the-association-analysis-between-ace-and-actn3-genes-polymorphisms-and-endurance-capacity-in-young-cross-country-skiers-longitudinal-study
#20
Agnes Mägi, Eve Unt, Ele Prans, Liina Raus, Jaan Eha, Alar Veraksitš, Külli Kingo, Sulev Kõks
Endurance performance depends on the integration of several phenotypic traits influenced by multiple environmental and genetic factors. Objectives of the study were: (1) to examine the genotypic frequencies of the ACE I/D, ACTN3 R577X polymorphisms and endurance performance-related phenotypes, (2) to evaluate the dynamics of endurance performance parameters during a 5-year period in relation to ACE I/D and ACTN3 R577X genotypes in Estonian young skiers. Determination of VO2peak was performed in 58 skiers aged 15-19 years (41 males, 17 females) during a 5-year period...
June 2016: Journal of Sports Science & Medicine
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