keyword
MENU ▼
Read by QxMD icon Read
search

Brain tumor research

keyword
https://www.readbyqxmd.com/read/27900341/subventricular-zone-associated-glioblastoma-a-call-for-translational-research-to-guide-clinical-decision-making
#1
Andrew W Smith, Bhupesh Parashar, A Gabriella Wernicke
Glioblastoma (GBM) is both the most common and the most devastating primary cancer of the central nervous system, with an expected overall survival in most patients of about 14 months. Despite extensive research, outcomes for GBM have been largely unchanged since the introduction of temozolomide in 2005. We believe that in order to achieve a breakthrough in therapeutic management, we must begin to identify subtypes of GBM, and tailor treatment to best target a particular tumor's vulnerabilities. Our group has recently produced an examination of the clinical outcomes of radiation therapy directed at tumors that contact the subventricular zone (SVZ), the 3-5 mm lateral border of the lateral ventricles that contains the largest collection of neural stem cells in the adult brain...
2016: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/27899404/tapping-big-data-to-help-little-patients
#2
(no author information available yet)
Through a large-scale tumor-sequencing effort for pediatric brain cancer, researchers hope to bring personalized care to young patients.
November 29, 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27889994/pd-1-pd-ls-a-new-target-for-regulating-the-immunopathogenesis-in-central-nervous-system-disorders
#3
Jie Wu, Zhengquan Yu, Gang Chen
The central nervous system (CNS) was traditionally thought to tolerate inflammatory responses. However, CNS is not completely immune-privileged in recent researches. These responses including Microglia and macrophage activation and peripheral immune cells infiltration have been founded successively. Thus, the traditional view of the adult brain as an immune-privileged organ has been changed. Increasing evidence indicated that the PD-1(programmed cell death-1)/PD-Ls signal pathway plays an important role in regulating the immunopathogenesis of brain following injury...
November 23, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27886461/biomaterial-based-implantable-devices-for-cancer-therapy
#4
Sue Anne Chew, Serena Danti
This review article focuses on the current local therapies mediated by implanted macroscaled biomaterials available or proposed for fighting cancer and also highlights the upcoming research in this field. Several authoritative review articles have collected and discussed the state-of-the-art as well as the advancements in using biomaterial-based micro- and nano-particle systems for drug delivery in cancer therapy. On the other hand, implantable biomaterial devices are emerging as highly versatile therapeutic platforms, which deserve an increased attention by the healthcare scientific community, as they are able to offer innovative, more effective and creative strategies against tumors...
November 25, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27881951/neuronal-gene-targets-of-nf-%C3%AE%C2%BAb-and-their-dysregulation-in-alzheimer-s-disease
#5
REVIEW
Wanda M Snow, Benedict C Albensi
Although, better known for its role in inflammation, the transcription factor nuclear factor kappa B (NF-κB) has more recently been implicated in synaptic plasticity, learning, and memory. This has been, in part, to the discovery of its localization not just in glia, cells that are integral to mediating the inflammatory process in the brain, but also neurons. Several effectors of neuronal NF-κB have been identified, including calcium, inflammatory cytokines (i.e., tumor necrosis factor alpha), and the induction of experimental paradigms thought to reflect learning and memory at the cellular level (i...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27875627/immunotherapy-approaches-in-the-treatment-of-malignant-brain-tumors
#6
REVIEW
Anastasie M Dunn-Pirio, Gordana Vlahovic
Glioblastoma is the most common malignant primary brain tumor. Despite standard-of-care treatment, consisting of maximal surgical resection followed by chemoradiation, both morbidity and mortality associated with this disease remain very poor. Therefore, there is an urgent need for more efficacious and well tolerated therapies. Advancing knowledge of the intricate interplay between malignant gliomas and the immune system, coupled with the recent launch of immunotherapy research for other cancers, has led to a veritable increase in immunotherapy investigation for glioblastoma and other malignant gliomas...
November 22, 2016: Cancer
https://www.readbyqxmd.com/read/27867917/health-related-quality-of-life-in-brain-tumor-patients-treated-with-surgery-preliminary-result-of-a-single-institution
#7
Chang-Wook Kim, Jin-Deok Joo, Young-Hoon Kim, Jung Ho Han, Chae-Yong Kim
BACKGROUND: Alongside the extent of removal and patients' survival in the management of brain tumors, health-related quality of life (HRQOL) has become an important consideration. The purpose of this study is to evaluate the change of HRQOL in brain tumor patients before and after surgery and to assess the associated factors that contribute to the change of HRQOL. METHODS: A total of 258 patients who underwent surgical treatment were enrolled in this study. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC QLQ-C30) and the 20-item EORTC QLQ-Brain Neoplasm (QLQ-BN20) were used to assess HRQOL...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27864705/the-clinical-and-financial-impact-of-a-pediatric-surgical-neuro-oncology-clinical-trial
#8
Eric M Thompson, Sridharan Gururangan, Gerald Grant, Duane Mitchell, John H Sampson
Pediatric surgical trials are rare and the impact of such trials on the institutions in which they are conducted is unknown. The purpose of this study was to analyze the clinical and financial impact of The Re-MATCH trial, a Phase I clinical trial requiring the biopsy or resection of recurrent medulloblastoma or PNET for enrollment. Inpatient financial and clinical volume information was collected during the 3 years of trial enrollment and the years preceding and following it. The primary endpoints were the difference in direct contribution margin (DCM), or net gain, of study and non-study patients and the difference in surgical volume during the study and non-study periods...
November 18, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27864281/lipoprotein-lipase-and-phospholipid-transfer-protein-overexpression-in-human-glioma-cells-and-their-effect-on-cell-growth-apoptosis-and-migration
#9
Weijiang Dong, Huilin Gong, Guanjun Zhang, Simona Vuletic, John Albers, Jiaojiao Zhang, Hua Liang, Yanxia Sui, Jin Zheng
Glioma is one of the common tumors in brain. The expression level of lipoprotein lipase (LPL) or phospholipid transfer protein (PLTP) may influence glioma progression and its relationship with clinical and pathological parameters. The clinical significance of LPL or PLTP expression in glioma has not been established. In the present study, the LPL and PLTP levels in glioma tumors were investigated and the relationship between the LPL and PLTP level and the grade of malignant glioma was analyzed, with the aim to provide new ideas for the diagnosis and treatment of gliomas in clinical and basic research settings...
November 17, 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/27864083/robust-skull-stripping-using-multiple-mr-image-contrasts-insensitive-to-pathology
#10
Snehashis Roy, John A Butman, Dzung L Pham
Automatic skull-stripping or brain extraction of magnetic resonance (MR) images is often a fundamental step in many neuroimage processing pipelines. The accuracy of subsequent image processing relies on the accuracy of the skull-stripping. Although many automated stripping methods have been proposed in the past, it is still an active area of research particularly in the context of brain pathology. Most stripping methods are validated on T1-w MR images of normal brains, especially because high resolution T1-w sequences are widely acquired and ground truth manual brain mask segmentations are publicly available for normal brains...
November 15, 2016: NeuroImage
https://www.readbyqxmd.com/read/27863971/systemic-inaccuracies-in-the-national-surgical-quality-improvement-program-database-implications-for-accuracy-and-validity-for-neurosurgery-outcomes-research
#11
John D Rolston, Seunggu J Han, Edward F Chang
The American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) provides a rich database of North American surgical procedures and their complications. Yet no external source has validated the accuracy of the information within this database. Using records from the 2006 to 2013 NSQIP database, we used two methods to identify errors: (1) mismatches between the Current Procedural Terminology (CPT) code that was used to identify the surgical procedure, and the International Classification of Diseases (ICD-9) post-operative diagnosis: i...
November 15, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27862183/the-antiviral-cytokine-interferon-gamma-restricts-neural-stem-progenitor-cell-proliferation-through-activation-of-stat1-and-modulation-of-retinoblastoma-protein-phosphorylation
#12
Apurva Kulkarni, Taylor J Scully, Lauren A O'Donnell
Neural stem/progenitor cells (NPSCs) express receptors for many inflammatory cytokines, with varying effects on differentiation and proliferation depending on the stage of development and the milieu of inflammatory mediators. In primary neurons and astrocytes, we recently showed that interferon gamma (IFNγ), a potent antiviral cytokine that is required for the control and clearance of many central nervous system (CNS) infections, could differentially affect cell survival and cell cycle progression depending upon the cell type and the profile of activated intracellular signaling molecules...
November 15, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27861763/assessment-of-the-treatment-approach-and-survival-outcomes-in-a-modern-cohort-of-patients-with-atypical-teratoid-rhabdoid-tumors-using-the-national-cancer-database
#13
Benjamin W Fischer-Valuck, Ishita Chen, Amar J Srivastava, John M Floberg, Yuan James Rao, Allison A King, Eric T Shinohara, Stephanie M Perkins
BACKGROUND: Atypical teratoid rhabdoid tumors (ATRTs) are rare brain tumors that occur primarily in children under the age of 3 years. This report evaluates the treatment approach and survival outcomes in a large cohort of patients treated in the United States. METHODS: Using the National Cancer Database, the analysis included all ATRT patients aged 0 to 18 years who were diagnosed between 2004 and 2012 and had complete treatment data. RESULTS: Three hundred sixty-one ATRT patients were evaluated...
November 2, 2016: Cancer
https://www.readbyqxmd.com/read/27856651/flat-detector-computed-tomography-pbv-map-in-the-evaluation-of-presurgical-embolization-for-hypervascular-brain-tumors
#14
Li-Li Wen, Xin Zhang, Qing-Rong Zhang, Qi Wu, Shu-Juan Chen, Jin-Long Deng, Kaiyi Huang, Han-Dong Wang
BACKGROUND: Preoperative embolization of hypervascular brain tumors is frequently used to minimize intraoperative bleeding. OBJECTIVE: To explore the efficacy of embolization using flat-detector CT (FDCT) parenchymal blood volume (PBV) maps before and after the intervention. MATERIALS AND METHODS: Twenty-five patients with hypervascular brain tumors prospectively received pre- and postprocedural FDCT PBV scans using a biplane system under a protocol approved by the institutional research ethics committee...
November 17, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27853959/epidemiology-for-primary-brain-tumors-a-nationwide-population-based-study
#15
Amélie Darlix, Sonia Zouaoui, Valérie Rigau, Faiza Bessaoud, Dominique Figarella-Branger, Hélène Mathieu-Daudé, Brigitte Trétarre, Fabienne Bauchet, Hugues Duffau, Luc Taillandier, Luc Bauchet
Primary central nervous system tumors (PCNST) are rare tumors responsible for high mortality and morbidity. Their epidemiology is poorly known, and clinical data are scarcely analyzed at a national level. In this study, we aimed at providing descriptive epidemiological data and incidence rates for all histological subtypes of PCNST according to the WHO classification. We conducted a nationwide population-based study of all newly diagnosed and histologically confirmed PCNST in France, between 2006 and 2011. A total of 57,816 patients were included: male 46...
November 16, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27851995/key-clinical-benefits-of-neuroimaging-at-7t
#16
Siegfried Trattnig, Elisabeth Springer, Wolfgang Bogner, Gilbert Hangel, Bernhard Strasser, Barbara Dymerska, Pedro Lima Cardoso, Simon Daniel Robinson
The growing interest in ultra-high field MRI, with more than 35.000 MR examinations already performed at 7T, is related to improved clinical results with regard to morphological as well as functional and metabolic capabilities. Since the signal-to-noise ratio increases with the field strength of the MR scanner, the most evident application at 7T is to gain higher spatial resolution in the brain compared to 3T. Of specific clinical interest for neuro applications is the cerebral cortex at 7T, for the detection of changes in cortical structure, like the visualization of cortical microinfarcts and cortical plaques in Multiple Sclerosis...
November 13, 2016: NeuroImage
https://www.readbyqxmd.com/read/27843735/interhemispheric-difference-images-from-postoperative-diffusion-tensor-imaging-of-gliomas
#17
Robert Kosztyla, Stefan A Reinsberg, Vitali Moiseenko, Brian Toyota, Alan Nichol
Introduction Determining the full extent of gliomas during radiotherapy planning can be challenging with conventional T1 and T2 magnetic resonance imaging (MRI). The purpose of this study was to develop a method to automatically calculate differences in the fractional anisotropy (FA) and mean diffusivity (MD) values in target volumes obtained with diffusion tensor imaging (DTI) by comparing with values from anatomically homologous voxels on the contralateral side of the brain. Methods Seven patients with a histologically confirmed glioma underwent postoperative radiotherapy planning with 1...
October 5, 2016: Curēus
https://www.readbyqxmd.com/read/27836863/checkpoint-proteins-in-pediatric-brain-and-extracranial-solid-tumors-opportunities-for-immunotherapy
#18
Eric K Ring, James M Markert, G Yancey Gillespie, Gregory K Friedman
Pediatric brain and extracranial solid tumors are a diverse group of malignancies that represent almost half of pediatric cancers. Standard therapy includes various combinations of surgery, cytotoxic chemotherapy and radiation, which can be very harmful to a developing child, and survivors carry a substantial burden of long term morbidities. While these therapies have improved survival rates for children with solid tumors, outcomes still remain extremely poor for subsets of patients. Recently, immunosuppressive checkpoint molecules that negatively regulate immune cell function have been described...
November 10, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27833756/presurgical-assessment-of-cognitive-function-in-pediatric-brain-tumor-patients-feasibility-and-initial-findings
#19
Jennifer C Thigpen, Matthew Pearson, Kristen E Robinson, Charissa Andreotti, Jennifer P Dunbar, Kelly H Watson, Leandra Dejardins, Lindsay Holmes, Rebecca Byram, Claire Fraley, Bruce E Compas
BACKGROUND: Establishing a presurgical baseline of neurocognitive functioning for pediatric brain tumor patients is a high priority to identify level of functioning prior to medical interventions. However, few studies have obtained adequate samples of presurgery assessments. METHODS: This study examines the feasibility of completing tests to assess pre-surgical neurocognitive functioning in 59 identified pediatric brain tumor patients. RESULTS: Eighty-five percent of patients (n = 50) were referred by the neurosurgery team before surgery and 83% of patients (n = 49) enrolled in the study...
December 2016: Neuro-oncology Practice
https://www.readbyqxmd.com/read/27830712/a-dynamic-in-vivo-like-organotypic-blood-brain-barrier-model-to-probe-metastatic-brain-tumors
#20
Hui Xu, Zhongyu Li, Yue Yu, Saman Sizdahkhani, Winson S Ho, Fangchao Yin, Li Wang, Guoli Zhu, Min Zhang, Lei Jiang, Zhengping Zhuang, Jianhua Qin
The blood-brain barrier (BBB) restricts the uptake of many neuro-therapeutic molecules, presenting a formidable hurdle to drug development in brain diseases. We proposed a new and dynamic in vivo-like three-dimensional microfluidic system that replicates the key structural, functional and mechanical properties of the blood-brain barrier in vivo. Multiple factors in this system work synergistically to accentuate BBB-specific attributes-permitting the analysis of complex organ-level responses in both normal and pathological microenvironments in brain tumors...
November 10, 2016: Scientific Reports
keyword
keyword
42941
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"