Wenbo Zhao, Sijie Li, Chuanhui Li, Chuanjie Wu, Junmei Wang, Lifei Xing, Yue Wan, Jinhui Qin, Yaoming Xu, Ruixian Wang, Changming Wen, Aihua Wang, Lan Liu, Jing Wang, Haiqing Song, Wuwei Feng, Qingfeng Ma, Xunming Ji
IMPORTANCE: Evidence supports using antiplatelet therapy in patients with acute ischemic stroke. However, neurological deterioration remains common under the currently recommended antiplatelet regimen, leading to poor clinical outcomes. OBJECTIVE: To determine whether intravenous tirofiban administered within 24 hours of stroke onset prevents early neurological deterioration in patients with acute noncardioembolic stroke compared with oral aspirin. DESIGN, SETTING, AND PARTICIPANTS: This investigator-initiated, multicenter, open-label, randomized clinical trial with blinded end-point assessment was conducted at 10 comprehensive stroke centers in China between September 2020 and March 2023...
April 22, 2024: JAMA Neurology