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https://www.readbyqxmd.com/read/29331887/idh1r132h-promotes-malignant-transformation-of-benign-prostatic-epithelium-by-dysregulating-micrornas-involvement-of-igf1r-akt-stat3-signaling-pathway
#1
Lili Zhang, Mei Qi, Tingting Feng, Jing Hu, Lin Wang, Xinjun Li, Wei Gao, Hui Liu, Meng Jiao, Zhen Wu, Xinnuo Bai, Yifan Bie, Long Liu, Bo Han
Risk stratification using molecular features could potentially help distinguish indolent from aggressive prostate cancer (PCa). Mutations in isocitrate dehydrogenase (IDH) acquire an abnormal enzymatic activity, resulting in the production of 2-hydroxyglutarate and alterations in cellular metabolism, histone modification, and DNA methylation. Mutant IDH1 has been identified in various human malignancies, and IDH1R132H constituted the vast majority of mutational events of IDH1. Most recent studies suggested that IDH1 mutations define a methylator subtype in PCa...
January 11, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29331880/preventive-effects-of-indole-3-carbinol-against-alcohol-induced-liver-injury-in-mice-via-antioxidant-anti-inflammatory-and-anti-apoptotic-mechanisms-role-of-gut-liver-adipose-tissue-axis
#2
Youngshim Choi, Mohamed A Abdelmegeed, Byoung-Joon Song
Indole-3-carbinol (I3C), found in Brassica family vegetables, exhibits antioxidant, anti-inflammatory, and anti-cancerous properties. Here, we aimed to evaluate the preventive effects of I3C against ethanol (EtOH)-induced liver injury and study the protective mechanism(s) by using the well-established chronic-plus-binge alcohol exposure model. The preventive effects of I3C were evaluated by conducting various histological, biochemical, and real-time PCR analyses in mouse liver, adipose tissue, and colon, since functional alterations of adipose tissue and intestine can also participate in promoting EtOH-induced liver damage...
December 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29331029/characterization-of-cd34-hematopoietic-cells-in-systemic-mastocytosis-potential-role-in-disease-dissemination
#3
Andrea Mayado, Cristina Teodosio, Noelia Dasilva Freire, Maria Jara-Acevedo, Andrés C Garcia-Montero, Ivan Álvarez-Twose, Laura Sánchez-Muñoz, Almudena Matito, Carolina Caldas, Javier I Muñoz-González, Ana Henriques, José I Sánchez-Gallego, Luis Escribano, Alberto Orfao
BACKGROUND: Recent studies show that most systemic mastocytosis (SM) patients, including indolent SM (ISM) with (ISMs+) and without skin lesions (ISMs-), carry the KIT D816V mutation in PB leukocytes. We investigated the potential association between the degree of involvement of BM hematopoiesis by the KIT D816V mutation and the distribution of different maturation-associated compartments of bone marrow (BM) and peripheral blood (PB) CD34+ hematopoietic precursors (HPC) in ISM, and identified the specific PB cell compartments that carry this mutation...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29330819/preparation-of-a-synthetic-seed-for-the-common-reed-harboring-an-endophytic-bacterium-promoting-seedling-growth-under-cadmium-stress
#4
Ting Gao, Xianyang Shi
Bacterial seed endophytes can facilitate germination and early plant development. Therefore, the introduction of seed-borne endophytes may improve selected plant characteristics across generations. In this study, regenerated plantlets of common reed (Phragmites australis) were inoculated with activated sludge to obtain a specific functional endophytic bacterium. Denaturing gradient gel electrophoresis demonstrated that abundant endophytic bacteria could be enriched in the roots. A siderophore-producing endophytic bacterium was isolated from the roots and identified as Herbaspirillum frisingense RE3-3 based on 16S rRNA sequences...
January 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29330072/chronic-thigh-pain-in-a-young-adult-diagnosed-as-synovial-sarcoma-a-case-report
#5
Lauren A Chambers, John M Lesher
Synovial sarcoma is a slow growing, intermediate to high grade neoplasm with extensive metastatic potential. Accurate diagnosis of synovial sarcoma may pose a challenge to providers because of its indolent growth and variable presentation. The findings of a soft-tissue, periarticular mass with calcifications in a young patient are highly suggestive of synovial sarcoma. Although different imaging modalities can aid in the diagnosis of synovial sarcoma, diagnostic certainty is typically only confirmed by biopsy and histological analysis...
January 9, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29327073/azospirillum-brasilense-increases-co2-fixation-on-microalgae-scenedesmus-obliquus-chlorella-vulgaris-and-chlamydomonas-reinhardtii-cultured-on-high-co2-concentrations
#6
Francisco J Choix, Cecilia Guadalupe López-Cisneros, Hugo Oscar Méndez-Acosta
Mutualism interactions of microalgae with other microorganisms are widely used in several biotechnological processes since symbiotic interaction improves biotechnological capabilities of the microorganisms involved. The interaction of the bacterium Azospirillum brasilense was assessed with three microalgae genus, Scenedesmus, Chlorella, and Chlamydomonas, during CO2 fixation under high CO2 concentrations. The results in this study have demonstrated that A. brasilense maintained a mutualistic interaction with the three microalgae assessed, supported by the metabolic exchange of indole-3-acetic acid (IAA) and tryptophan (Trp), respectively...
January 11, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/29324661/protein-activity-of-the-fusarium-fujikuroi-rhodopsins-caro-and-opsa-and-their-relation-to-fungus-plant-interaction
#7
Alexander Adam, Stephan Deimel, Javier Pardo-Medina, Jorge García-Martínez, Tilen Konte, M Carmen Limón, Javier Avalos, Ulrich Terpitz
Fungi possess diverse photosensory proteins that allow them to perceive different light wavelengths and to adapt to changing light conditions in their environment. The biological and physiological roles of the green light-sensing rhodopsins in fungi are not yet resolved. The rice plant pathogen Fusarium fujikuroi exhibits two different rhodopsins, CarO and OpsA. CarO was previously characterized as a light-driven proton pump. We further analyzed the pumping behavior of CarO by patch-clamp experiments. Our data show that CarO pumping activity is strongly augmented in the presence of the plant hormone indole-3-acetic acid and in sodium acetate, in a dose-dependent manner under slightly acidic conditions...
January 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29324242/expression-profiling-of-the-dolichos-lablab-lectin-during-germination-and-development-of-the-seed
#8
Yashavanth L Vishweshwaraiah, Balaji Prakash, Lalitha R Gowda
The temporal expression of the field bean (Dolichos lablab) galactose specific lectin, DLL-II, during germination, post-germination and seed development was evaluated using Native-PAGE followed by activity staining, immunodetection and quantitative Real Time PCR (qPCR). A rapid and steep decline in the polyphenol oxidase (PPO) and hemagglutinating activity during the initial stages of germination, which did not correlate with the slow decline in total protein was observed. During post germination period, PPO and hemagglutination activities were negligible, whereas a rapid resorption of the protein was evident...
January 4, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29324212/managing-patients-with-oligometastatic-non-small-cell-lung-cancer
#9
Sarah Jo Stephens, Michael J Moravan, Joseph K Salama
Metastatic lung cancer has long been considered incurable, with the goal of treatment being palliation. However, a clinically meaningful number of these patients with limited metastases (approximately 25%) are living long term after definitive treatment to all sites of active disease. These patients with so-called oligometastatic disease likely represent a distinct clinical group who may possess a more indolent biology compared with their more widely metastatic counterparts. Hellman and Weichselbaum proposed the existence of the oligometastatic state, on the basis of the spectrum theory of cancer spread...
January 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29323899/optimization-of-potent-and-selective-tricyclic-indole-diazepinone-myeloid-cell-leukemia-1-mcl-1-inhibitors-using-structure-based-design
#10
Subrata Shaw, Zhiguo Bian, Bin Zhao, James C Tarr, Nagarathanam Veerasamy, KyuOk Jeon, Johannes Belmar, Allison L Arnold, Stuart A Fogarty, Evan Perry, John L Sensintaffar, DeMarco V Camper, Olivia W Rossanese, Taekyu Lee, Edward T Olejniczak, Stephen W Fesik
Myeloid cell leukemia 1 (Mcl-1), an anti-apoptotic member of the Bcl-2 family of proteins, has emerged as an attractive target for cancer therapy. Mcl-1 upregulation is often found in many human cancers and is associated with high tumor grade, poor survival, and resistance to chemotherapy. Here we describe a series of potent and selective tricyclic indole diazepinone Mcl-1 inhibitors that were discovered and further optimized using structure-based design. These compounds exhibit picomolar binding affinity and mechanism-based cellular efficacy, including growth inhibition and caspase induction in Mcl-1 sensitive cells...
January 11, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29323750/design-synthesis-and-molecular-docking-of-novel-indole-scaffold-based-vegfr-2-inhibitors-as-targeted-anticancer-agents
#11
Hanaa M Roaiah, Iman A Y Ghannam, Islam H Ali, Ahmed M El Kerdawy, Mamdouh M Ali, Safinaz E-S Abbas, Sally S El-Nakkady
A series of new indole derivatives 1-18 was synthesized and tested for their cytotoxic activity on a panel of 60 tumor cell lines. Additionally, molecular docking was carried out to study their binding pattern and binding affinity in the VEGFR-2 active site using sorafenib as a reference VEGFR-2 inhibitor. Based on the molecular docking results, compounds 5a, 5b, 6, 7, 14b, 18b, and 18c were selected to be evaluated for their VEGFR-2 inhibitory activity. Compound 18b exhibited a broad-spectrum antiproliferative activity on 47 cell lines, with GI % ranging from 31 to 82...
January 11, 2018: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29321563/probiotic-activities-of-rhizobium-laguerreae-on-growth-and-quality-of-spinach
#12
Alejandro Jiménez-Gómez, José David Flores-Félix, Paula García-Fraile, Pedro F Mateos, Esther Menéndez, Encarna Velázquez, Raúl Rivas
The growing interest in a healthy lifestyle and in environmental protection is changing habits regarding food consumption and agricultural practices. Good agricultural practice is indispensable, particularly for raw vegetables, and can include the use of plant probiotic bacteria for the purpose of biofertilization. In this work we analysed the probiotic potential of the rhizobial strain PEPV40, identified as Rhizobium laguerreae through the analysis of the recA and atpD genes, on the growth of spinach plants...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320754/characteristics-of-cribriform-morular-variant-of-papillary-thyroid-carcinoma-in-post-chernobyl-affected-region
#13
Alfred King-Yin Lam, Mikhail Fridman
The aim is to study the characteristics of cribriform morular variant of papillary thyroid carcinoma (CMV-PTC) in patients living in radiation-affected area of Belarus. The clinical and pathological features of 35 patients with CMV-PTC from Belarus were studied and compared with those of conventional papillary thyroid carcinoma diagnosed in the same period. The patients with CMV-PTC were all females and were younger at presentation (mean age = 24) than those with conventional papillary thyroid carcinoma. Familial adenomatous polyposis (FAP) was identified in 20% of the patients with CMV-PTC...
January 7, 2018: Human Pathology
https://www.readbyqxmd.com/read/29320368/pobeguinine-a-monoterpene-indole-alkaloid-and-other-bioactive-constituents-from-the-stem-bark-of-nauclea-pobeguinii
#14
Jean J K Bankeu, Stéphanie Madjouka, Guy R T Feuya, Yannick S F Fongang, Sadaf Siddiqui, Iftikhar Ali, Lateef Mehreen, Bruno N Lenta, Sammer Yousuf, Didérot T Noungoué, Augustin S Ngouela, Muhammad S Ali
Phytochemical investigation of dichloromethane neutral phase of stem bark of Nauclea pobeguinii led to the isolation of a new monoterpene indole alkaloid, pobeguinine 1 along with 14 known compounds including (-)-naucleofficine D (2a), (+)-naucleofficine D (2b), naucleidinal (3), quafrinoic acid (4), betulinic acid (5), ursolic acid (6), quinovic acid (7), quinovic acid 3-O-α-L-rhamnopyranoside (8a), quinovic acid 3-O-β-D-fucopyranoside (8b), β-sitosterol (9), β-sitosterol 3-O-β-D-glucopyranoside (10), benzoic acid (11), lacceroic acid (12) and n-heptacosane (13)...
January 10, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/29320183/six-trikentrin-like-cyclopentanoindoles-from-trikentrion-flabbeliforme-absolute-structural-assignment-by-nmr-and-ecd
#15
Mariam N Salib, Tadeusz F Molinski
Six new cyclopenta[g]indoles were isolated from a West Australian sponge, Trikentrion flabbeliforme Hentschel, 1912 and their structures elucidated by integrated spectroscopic analysis. The compounds are analogs of previously described trikentrins, herbindoles and trikentramides from related Axinellid sponges. The assignment of absolute configuration of the new compounds was carried out largely by comparative analysis of specific rotation, calculated and measured ECD and exploiting van't Hoff's principle of optical superposition...
January 10, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29320164/mechanistic-investigations-of-lysine-tryptophan-crosslink-formation-catalyzed-by-streptococcal-radical-sam-enzymes
#16
Kelsey R Schramma, Clarissa C Forneris, Alessio Caruso, Mohammad R Seyedsayamdost
Streptide is a ribosomally synthesized and post-translationally modified peptide with a unique cyclization motif consisting of an intramolecular lysine-tryptophan crosslink. Three radical SAM enzymes, StrB, AgaB, and SuiB from different Streptococci, have been shown to install this modification onto their respective precursor peptides in a leader-dependent fashion. Herein we conduct detailed investigations to differentiate between several plausible mechanistic proposals, specifically addressing radical versus electrophilic addition to the indole during crosslink formation, the role of substrate side-chains in binding in the enzyme active site, and the identity of the catalytic base in the reaction cycle...
January 10, 2018: Biochemistry
https://www.readbyqxmd.com/read/29319097/conformational-stabilization-of-a-%C3%AE-hairpin-through-a-triazole-tryptophan-interaction
#17
Donatella Diana, Claudia Di Salvo, Veronica Celentano, Lucia De Rosa, Alessandra Romanelli, Roberto Fattorusso, Luca D D'Andrea
Molecular tools to stabilize the β-hairpin conformation are needed as β-hairpin peptides are useful molecules for pharmaceutical, biological and materials applications. We explored the use of a "triazole bridge", a covalent link between two β-hairpin strands obtained through Cu-catalyzed alkyne-azide cycloaddition, combined with an aromatic-aromatic interaction. Highly conformationally stable peptides were identified by NMR screening of a small collection of cyclic peptides based on the Trpzip2 scaffold...
January 10, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29318292/synthesis-and-structure-activity-relationship-of-some-indole-derivatives-as-potential-anti-inflammatory-agents
#18
Samar S Fatahala, Mohammed A Khedr, Mossad S Mohamed
A series of fused pyrroles were synthesized and tested for their in vivo anti-inflammatory activity. Among 14 examined derivatives, 5 derivatives (1b-e, g and 5b), showed a promising anti-inflammatory activity equivalent to reference anti-inflammatory drugs (indomethacin and ibuprofen). A molecular docking study was conducted to interpret the biological activities of the tested compounds. The docking results were complementary with the phase of the biological survey and confirmed the biological effects.
December 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/29317554/bendamustine-plus-rituximab-versus-r-chop-as-first-line-treatment-for-patients-with-follicular-lymphoma-grade-3a-evidence-from-a-multicenter-retrospective-study
#19
Patrizia Mondello, Normann Steiner, Wolfgang Willenbacher, Claudio Cerchione, Davide Nappi, Endri Mauro, Simone Ferrero, Salvatore Cuzzocrea, Michael Mian
BACKGROUND: Rituximab plus bendamustine (R-B) has been demonstrated to improve outcomes and reduce toxicity compared with rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHOP) in follicular lymphoma (FL). Nevertheless, in clinical practice, many centers still prefer R-CHOP to R-B in patients with FL grade 3A (FL3A). Therefore, we retrospectively assessed patients with FL3A treated with either R-CHOP or R-B in five European cancer centers and compared their outcomes. MATERIALS AND METHODS: We retrospectively assessed 132 patients affected by FL grade 3A treated with either R-B or R-CHOP in the first line and evaluated outcome and toxicity according to the type of treatment...
January 9, 2018: Oncologist
https://www.readbyqxmd.com/read/29316724/biochemical-and-clinical-impact-of-organic-uremic-retention-solutes-a-comprehensive-update
#20
REVIEW
Raymond Vanholder, Anneleen Pletinck, Eva Schepers, Griet Glorieux
In this narrative review, the biological/biochemical impact (toxicity) of a large array of known individual uremic retention solutes and groups of solutes is summarized. We classified these compounds along their physico-chemical characteristics as small water-soluble compounds or groups, protein bound compounds and middle molecules. All but one solute (glomerulopressin) affected at least one mechanism with the potential to contribute to the uremic syndrome. In general, several mechanisms were influenced for each individual solute or group of solutes, with some impacting up to 7 different biological systems of the 11 considered...
January 8, 2018: Toxins
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