keyword
MENU ▼
Read by QxMD icon Read
search

Indole

keyword
https://www.readbyqxmd.com/read/28816392/phosphine-catalyzed-enantioselective-formal-4-4-annulation-of-alpha-beta-unsaturated-imines-and-allene-ketones-construction-of-eight-membered-rings
#1
Yixin Lu, Huanzhen Ni, Xiaodong Tang, Wenrui Zheng, Weijun Yao, Nisar Ullah
The first highly enantioselective phosphine-catalyzed formal[4+4] annulation has been developed. In the presence of amino acid-derived phosphines, the unprecedented formal [4+4] annulations between benzofuran/indole derived α,β-unsaturated imines and allene ketones proceeded smoothly, affording azocines bearing a benzofuran or an indole moiety in excellent yields and with nearly perfect enantioselectivities (≥98% ee in most cases). This work marks the first efficient asymmetric construction of optically enriched eight-membered rings via phosphine catalysis...
August 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28816332/phosphine-catalyzed-intramolecular-rauhut-currier-reaction-enantioselective-synthesis-of-hydro-2h-indole-derivatives
#2
Hongxing Jin, Qinglong Zhang, Erqing Li, Penghao Jia, Ning Li, You Huang
A highly enantioselective intramolecular Rauhut-Currier reaction catalyzed by a multifunctional chiral aminophosphine catalyst was reported. A series of hydro-2H-indole derivatives that bear an all-carbon quaternary center were obtained in high yields (up to 94%), and excellent diastereo- and enantioselectivities (up to >20 : 1 dr and >99% ee). And this reaction could be performed on a gram scale using 2 mol% catalyst loading.
August 17, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28815946/model-catalytic-studies-of-novel-liquid-organic-hydrogen-carriers-indole-indoline-and-octahydroindole-on-pt-111
#3
Matthias Schwarz, Philipp Bachmann, Thais Nascimento Silva, Susanne Mohr, Marlene Scheuermeyer, Florian Späth, Udo Bauer, Fabian Düll, Johann Steinhauer, Chantal Hohner, Tibor Döpper, Heshmat Noei, Andreas Stierle, Christian Papp, Hans-Peter Steinrück, Peter Wasserscheid, Andreas Görling, Jörg Libuda
Indole derivatives were recently proposed as potential Liquid Organic Hydrogen Carriers (LOHC) for storage of renewable energies. In this work, we have investigated the adsorption, dehydrogenation and degradation mechanisms in the indole/indoline/octahydroindole system on Pt(111). We have combined infrared reflection absorption spectroscopy (IRAS), X-ray photoelectron spectroscopy (XPS) and density functional (DF) calculations. Indole multilayers show a crystallization transition at 200 K, in which the molecules adopt a strongly tilted orientation, before the multilayer desorbs at 220 K...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28815668/primary-low-grade-neuroendocrine-carcinoma-of-the-skin-an-exceedingly-rare-entity
#4
Tiffany Y Chen, Annie O Morrison, Joe Susa, Clay J Cockerell
Low-grade neuroendocrine tumors (NET), also known as carcinoid tumor, commonly arise from the gastrointestinal and pulmonary tracts, but rarely occur in the skin. Cutaneous NET typically occurs as metastases or high grade primary lesions, called Merkel cell carcinoma. In the few cases described in literature, primary low-grade neuroendocrine carcinomas of the skin (LGNECS) are usually indolent cutaneous nodules, presenting on the head and trunk of elderly patients. LGNECS tumors are histologically similar to its counterparts arising in other anatomic locations...
August 16, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28815550/fertility-preservation-in-women-with-borderline-ovarian-tumors-how-does-it-impact-disease-outcome-a-cohort-study
#5
Limor Helpman, Assaf Yaniv, Mario E Beiner, Sarit Aviel-Ronen, Tamar Perri, Gilad Ben-Baruch, Liat Hogen Ben-David, Ariella Jakobson-Setton, Jacob Korach
INTRODUCTION: Borderline ovarian tumors are typically indolent neoplasms. Since many are diagnosed in younger women, fertility conservation is an important consideration and has been advocated based on retrospective data. The objective of this study was to identify features impacting on recurrence and survival in a series of borderline ovarian tumors, and to assess the safety of a fertility-sparing approach. MATERIAL AND METHODS: A historical cohort study of consecutive borderline ovarian tumors cases treated at a single institution over 30 years (1981-2011)...
August 16, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28815289/-aggressive-primary-cutaneous-b-cell-lymphomas-and-novel-ebv-entities
#6
REVIEW
C Lamos, E Dippel
Primary cutaneous large B‑cell lymphomas (PCBLT), EBV-positive large B‑cell lymphomas, not otherwise specified (EBV+ DLBCL, NOS), and primary cutaneous intravascular large B‑cell lymphomas (PCIVLBL) are recognized as cutaneous lymphomas with intermediate to poor prognosis. Differentiation from indolent B‑cell lymphomas or other pathologies of the skin can be complex, both clinically and histologically, but vital for the outcome of the patient. The combination of immunotherapy and polychemotherapy regimens, such as R‑CHOP, has led to significant improvements in prognosis, especially in diffuse large B‑cell lymphomas...
August 16, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28813061/indole-synthesis-by-palladium-catalyzed-tandem-allylic-isomerization-furan-diels-alder-reaction
#7
Jie Xu, Peter Wipf
A Pd(0)-catalyzed elimination of an allylic acetate generates a π-allyl complex that is postulated to initiate a novel intramolecular Diels-Alder cycloaddition to a tethered furan (IMDAF). Under the reaction conditions, this convergent, microwave-accelerated cascade process provides substituted indoles in moderate to good yields after Pd-hydride elimination, aromatization by dehydration, and in situ N-Boc cleavage.
August 16, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28813005/identification-and-functional-divergence-analysis-of-wox-gene-family-in-paper-mulberry
#8
Feng Tang, Naizhi Chen, Meiling Zhao, Yucheng Wang, Ruiping He, Xianjun Peng, Shihua Shen
The WOX (WUSCHEL-related homeobox) is a plant-specific transcription factor involved in plant development and stress response. However, few studies have been reported on the WOX gene in woody plants. In this study, 10 BpWOX genes were isolated from paper mulberry by RACE-PCR and categorized into three clades through phylogenetic analysis, ancient, intermediate and WUS clade. Among them, five members had the transcriptional activity detected by yeast one-hybrid and seven were uniquely localized to the nucleus through green fluorescent protein (GFP) observation...
August 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28812970/indole-3-carbinol-induces-g1-cell-cycle-arrest-and-apoptosis-through-aryl-hydrocarbon-receptor-in-thp-1-monocytic-cell-line
#9
Saeed Mohammadi, Fakhri Sadat Seyedhosseini, Nasser Behnampour, Yaghoub Yazdani
OBJECTIVES: The role of aryl hydrocarbon receptor (AhR) in carcinogenesis has been studied recently. Indole-3-carbinol (I3C) is an AhR agonist and a potential anticancer agent. Here, we investigated the effects of I3C on cell cycle progression and apoptosis through activation of AhR on THP-1 acute myeloid leukemia (AML) cell line. METHODS: MTT viability assay was used to measure the cytotoxic effects of I3C on THP-1 cells. Apoptosis and cell cycle assays were investigated using flow cytometry...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28811799/diversity-physiochemical-and-phylogenetic-analyses-of-bacteria-isolated-from-various-drinking-water-sources
#10
Neveen H Eid, Huda A Al Doghaither, Taha A Kumosani, Munazza Gull
OBJECTIVE: To evaluate the indigenous bacterial strains of drinking water from the most commercial water types including bottled and filtered water that are currently used in Saudi Arabia. METHODS: Thirty randomly selected commercial brands of bottled water were purchased from Saudi local markets. Moreover, samples from tap water and filtered water were collected in sterilized glass bottles and stored at 4°C. Biochemical analyses including pH, temperature, lactose fermentation test (LAC), indole test (IND), methyl red test (MR), Voges-Proskauer test (VP), urease test (URE), catalase test (CAT), aerobic and anaerobic test (Ae/An) were measured...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28811017/improved-methodology-for-analysis-of-multiple-phytohormones-using-sequential-magnetic-solid-phase-extraction-coupled-with-liquid-chromatography-tandem-mass-spectrometry
#11
Xiao-Tong Luo, Bao-Dong Cai, Xi Chen, Yu-Qi Feng
Phytohormones are special small molecules that play important role in plant growth and development at trace levels. Quantification of multiple phytohormones will be great helpful for researches about cross-talks that plant hormones regulate the responses of plants against both biotic and abiotic stresses by means of synergistic or antagonistic interactions. In the current study, we developed a method for profiling of phytohormones in one small sample, including indole-3-acetic acid, abscisic acid, jasmonic acid, gibberellins, cytokinins and brassinosteroids...
August 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28809552/characterization-of-2-oxindole-forming-heme-enzyme-mare-expanding-the-functional-diversity-of-the-tryptophan-dioxygenase-superfamily
#12
Yuyang Zhang, Yi Zou, Nelson L Brock, Tingting Huang, Yingxia Lan, Xiaozheng Wang, Zixin Deng, Yi Tang, Shuangjun Lin
3-Substituted 2-oxindoles are important structural motifs found in many biologically active natural products and pharmaceutical lead compounds. Here, we report an enzymatic formation of the 3-substituted 2-oxindoles catalyzed by MarE in the maremycin biosynthetic pathway in Streptomyces sp. B9173. MarE is a homologue of Fe(II)/heme-dependent tryptophan 2,3-dioxygenases (TDOs). Typical TDOs usually catalyze the insertion of two oxygen atoms from O2 into an indole ring to generate N-formylkynurenine (NFK)-like products...
August 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28808798/genetic-engineering-approach-using-early-vinca-alkaloid-biosynthesis-genes-led-to-increased-tryptamine-and-terpenoid-indole-alkaloids-biosynthesis-in-differentiating-cultures-of-catharanthus-roseus
#13
Abhishek Sharma, Priyanka Verma, Archana Mathur, Ajay Kumar Mathur
Catharanthus roseus today occupies the central position in ongoing metabolic engineering efforts in medicinal plants. The entire multi-step biogenetic pathway of its very expensive anticancerous alkaloids vinblastine and vincristine is fairly very well dissected at biochemical and gene levels except the pathway steps leading to biosynthesis of monomeric alkaloid catharanthine and tabersonine. In order to enhance the plant-based productivity of these pharma molecules for the drug industry, cell and tissue cultures of C...
August 14, 2017: Protoplasma
https://www.readbyqxmd.com/read/28808683/in-situ-generation-of-n-unsubstituted-imines-from-alkyl-azides-and-their-applications-for-imine-transfer-via-copper-catalysis
#14
Lu Hu, Yahu A Liu, Xuebin Liao
Although azides have been widely used in nitrene transfer reactions, in situ generation of N-H imines from azides for downstream transformations has rarely been explored. We report copper-mediated formation of N-unsubstituted aliphatic imines from easily available aliphatic azides using a customized phenanthroline-based ligand (L1*). Through trapping in situ-generated N-H imines, multisubstituted pyridines or indoles were readily synthesized. (13)C-labeled azide was used as part of an isotope labeling study, which suggests that the construction of pyridine derivatives involves a three-component dehydrogenative condensation...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28808514/nodular-pulmonary-amyloidosis-with-primary-pulmonary-malt-lymphoma-masquerading-as-metastatic-lung-disease
#15
Sunil Upadhaya, Mohd Baig, Basim Towfiq, Samer Al Hadidi
Nodular pulmonary amyloidosis is a very rare form of localized amyloidosis involving the lung, with very little known about its nature. It is usually associated with indolent B cell lymphoproliferative disorder and also connective tissue disorders. No definite treatment guideline exists. Many patients respond to chemotherapy with low risk of progression and a 'wait and watch' strategy is also considered a valid treatment option. In this report the authors present a case of nodular pulmonary amyloidosis with pulmonary mucosa associated lymphoid tissue (MALT) lymphoma that presented with features of metastatic malignant disease and after definitive diagnosis decided not to undergo treatment...
July 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28807943/chromatin-associated-protein-sin3b-prevents-prostate-cancer-progression-by-inducing-senescence
#16
Anthony J Bainor, Fang-Ming Deng, Yu Wang, Peng Lee, David J Cantor, Susan K Logan, Gregory David
Distinguishing between indolent and aggressive prostate adenocarcinoma (PCa) remains a priority to accurately identify patients who need therapeutic intervention. SIN3B has been implicated in the initiation of senescence in vitro Here we show that in a mouse model of prostate cancer, SIN3B provides a barrier to malignant progression. SIN3B was required for PTEN-induced cellular senescence and prevented progression to invasive PCa. Furthermore, SIN3B was downregulated in human PCa correlating with upregulation of its target genes...
August 14, 2017: Cancer Research
https://www.readbyqxmd.com/read/28807907/an-original-chemical-series-of-pyrimidine-biosynthesis-inhibitors-that-boost-the-antiviral-interferon-response
#17
Marianne Lucas-Hourani, Daniel Dauzonne, Hélène Munier-Lehmann, Samira Khiar, Sébastien Nisole, Julien Dairou, Olivier Helynck, Philippe V Afonso, Frédéric Tangy, Pierre-Olivier Vidalain
De novo pyrimidine biosynthesis is a key metabolic pathway involved in multiple biosynthetic processes. Here, we identified an original series of 3-(1H-indol-3-yl)-2,3-dihydro-4H-furo[3,2-c]chromen-4-one derivatives as a new class of pyrimidine biosynthesis inhibitors formed by two edge-fused polycyclic moieties. We show that identified compounds exhibit a broad-spectrum antiviral activity as well as immunostimulatory properties, in line with recent reports linking de novo pyrimidine biosynthesis with innate defense mechanisms against viruses...
August 14, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28806251/pet-ct-in-an-8-year-old-girl-with-epstein-barr-virus-associated-smooth-muscle-tumor
#18
Ishan Garg, Maria J Baladron Zanetti, Saba Yasir, Ajit H Goenka, Ayse T Kendi
Epstein-Barr virus-associated smooth muscle tumor is a rare indolent neoplasm, which can occur in unusual locations. It has been reported in immunosuppressed individuals in only 3 settings: posttransplant, human immunodeficiency virus infection, and primary immunodeficiency. Here, we present CT, MRI, and F-FDG PET/CT findings of Epstein-Barr virus-associated smooth muscle tumor in an 8-year-old girl with primary immunodeficiency and metachronous adrenal involvement.This is an open access article distributed under the Creative Commons Attribution License 4...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28805743/inhibitors-of-the-detoxifying-enzyme-of-the-phytoalexin-brassinin-based-on-quinoline-and-isoquinoline-scaffolds
#19
M Soledade C Pedras, Abbas Abdoli, Vijay K Sarma-Mamillapalle
The detoxification of the phytoalexin brassinin to indole-3-carboxaldehyde and S-methyl dithiocarbamate is catalyzed by brassinin oxidase (BOLm), an inducible fungal enzyme produced by the plant pathogen Leptosphaeria maculans. Twenty-six substituted quinolines and isoquinolines are synthesized and evaluated for antifungal activity against L. maculans and inhibition of BOLm. Eleven compounds that inhibit BOLm activity are reported, of which 3-ethyl-6-phenylquinoline displays the highest inhibitory effect. In general, substituted 3-phenylquinolines show significantly higher inhibitory activities than the corresponding 2-phenylquinolines...
August 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28805353/the-role-of-melatonin-receptor-mtnr1a-in-the-action-of-melatonin-on-bovine-granulosa-cells
#20
Shu-Juan Wang, Wen-Ju Liu, Li-Ke Wang, Xun-Sheng Pang, Li-Guo Yang
Granulosa cells (GCs) play an important role in ovarian follicle growth, development, and follicular atresia. In the present study, we investigated the effects of Melatonin on bovine GCs, and asked if MTNR1A was involved in their response to this indole hormone. Our results indicated that Melatonin inhibited GC apoptosis by up-regulating the expression of BCL2, BCL-XL, GPX4, and SOD1, and down-regulating the expression of BAX, CASP3, and TP53. Moreover, Melatonin modulated bovine GC function by decreasing the expression of INHA, INHBB, FSHR, and TGFBR3, and the abundance of Inhibin β and Activin B, while increasing the expression of LHR, INHBA, and secretion of progesterone by GCs...
August 14, 2017: Molecular Reproduction and Development
keyword
keyword
42932
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"