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https://www.readbyqxmd.com/read/28087412/pain-prediction-by-serum-biomarkers-of-bone-turnover-in-people-with-knee-osteoarthritis-an-observational-study-of-tracp5b-and-cathepsin-k-in-oa
#1
Lilian N Nwosu, Maximilian Allen, Laura Wyatt, Janet L Huebner, Victoria Chapman, David A Walsh, Virginia B Kraus
OBJECTIVES: To investigate serum biomarkers, tartrate resistant acid phosphatase 5b (TRAcP5b) and cathepsin K, indicative of osteoclastic bone resorption, and their relationship to pain and pain change in knee osteoarthritis (OA). METHODS: Sera and clinical data were collected from 129 people (97 with 3-year follow-up) with knee OA from the Prediction of Osteoarthritis Progression (POP) cohort. Knee OA-related outcomes in POP included: WOMAC pain, NHANES I (pain, aching and stiffness), subchondral sclerosis, and radiographically determined tibiofemoral and patellofemoral OA...
January 10, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28078435/the-effects-of-therapeutic-exercises-on-pain-muscle-strength-functional-capacity-balance-and-hemodynamic-parameters-in-knee-osteoarthritis-patients-a-randomized-controlled-study-of-supervised-versus-home-exercises
#2
Tuğba Kuru Çolak, Bahar Kavlak, Onur Aydoğdu, Emir Şahin, Gönül Acar, İlkşan Demirbüken, Zübeyir Sarı, İlker Çolak, Güven Bulut, M Gülden Polat
The aim of the study was to compare the effects of low-intensity exercise programs for lower extremities, either supervised or at home, on pain, muscle strength, balance and the hemodynamic parameters of knee osteoarthritis (OA) patients. This randomized study included 78 patients with knee OA in 2 groups of supervised and home-based exercise program. Exercises were applied to the first group in the clinic as a group exercise program and were demonstrated to the second group to be performed at home. Before and after the 6-week exercise program, assessment was made of pain, quadriceps and hamstring muscle strengths, 6-min walk test (6MWT), and non-invasive hemodynamic parameters...
January 11, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28073368/advanced-knee-structure-analysis-aksa-a-comparison-of-bone-mineral-density-and-trabecular-texture-measurements-using-computed-tomography-and-high-resolution-peripheral-quantitative-computed-tomography-of-human-knee-cadavers
#3
Torsten Lowitz, Oleg Museyko, Valérie Bousson, Christine Chappard, Liess Laouisset, Jean-Denis Laredo, Klaus Engelke
BACKGROUND: A change of loading conditions in the knee causes changes in the subchondral bone and may be a cause of osteoarthritis (OA). However, quantification of trabecular architecture in vivo is difficult due to the limiting spatial resolution of the imaging equipment; one approach is the use of texture parameters. In previous studies, we have used digital models to simulate changes of subchondral bone architecture under OA progression. One major result was that, using computed tomography (CT) images, subchondral bone mineral density (BMD) in combination with anisotropy and global homogeneity could characterize this progression...
January 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28068837/immediate-effects-of-acupuncture-treatment-on-intra-and-inter-limb-contributions-to-body-support-during-gait-in-patients-with-bilateral-medial-knee-osteoarthritis
#4
Yen-Hung Liu, I-Pin Wei, Ting-Ming Wang, Tung-Wu Lu, Jaung-Geng Lin
Knee osteoarthritis (OA) often leads to altered balance control, joint motion and loading patterns during gait. Acupuncture has been proven to be effective in pain relief but its effects on inter-joint load-sharing for body balance have not been reported. The current study bridged the gap by quantifying the immediate effects of acupuncture on the inter-joint and inter-limb load-sharing in patients with knee OA during level walking in terms of the total support moment (Ms) and the contribution of individual joints to the total support moment...
January 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28065216/expression-of-mirna-140-in-chondrocytes-and-synovial-fluid-of-knee-joints-in-patients-with-osteoarthritis
#5
Si Hai-Bo, Zeng Yi, Zhou Zong-Ke, Pei Fu-Xing, Lu Yan-Rong, Cheng Jing-Qiu, Shen Bin
Objective To investigate the expression of miRNA-140 in chondrocytes and synovial fluid of osteoarthritis (OA) patients, and explore the relationship between the miRNA-140 expression and OA severity.Methods This study enrolled 30 OA patients who underwent total knee arthroplasty for chondrocytes sampling and 30 OA patients who underwent intra-articular injection for synovial fluid sampling. All OA patients were grouped into mild [Kellgren and Lawrence (KL) grade 1-2], moderate (KL grade 3) and severe (KL grade 4), with 10 in each subgroups for each sampling purposes...
November 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28064223/influence-of-periostin-on-synoviocytes-in-knee-osteoarthritis
#6
Yutaro Tajika, Tatsuya Moue, Shintaro Ishikawa, Kazuhito Asano, Takayuki Okumo, Hiroshi Takagi, Tadashi Hisamitsu
BACKGROUND: Periostin (POSTN) is a protein that binds to integrins to support adhesion and migration of epithelial cells. Mice lacking this gene exhibit cardiac valve disease as well as skeletal and dental defects. Recent studies indicated that periostin is involved in the pathogenesis and progression of knee osteoarthritis (OA). We investigated the influence of periostin and matrix metalloproteinases (MMPs) on OA synoviocytes. MATERIALS AND METHODS: OA patients were classified according to the Kellgren-Lawrence system and the levels of periostin, interleukin (IL)-4, IL-13 and transforming growth factor-β (TGFβ) in the synovial fluid were measured...
January 2017: In Vivo
https://www.readbyqxmd.com/read/28064033/altered-gait-mechanics-and-elevated-serum-pro-inflammatory-cytokines-in-asymptomatic-patients-with-mri-evidence-of-knee-cartilage-loss
#7
Shannon N Edd, Julien Favre, Katerina Blazek, Patrick Omoumi, Jessica L Asay, Thomas P Andriacchi
OBJECTIVE: To test if sagittal plane gait mechanics parameters and serum inflammation levels differ between healthy asymptomatic subjects and asymptomatic subjects with magnetic resonance imaging (MRI) evidence of cartilage loss. DESIGN: Gait mechanics and resting serum tumor necrosis factor-α (TNFα) concentrations were measured for two groups of asymptomatic subjects recruited for a previous study: Pre-Osteoarthritis (OA) subjects had MRI evidence of partial- or full-thickness knee cartilage loss in at least one compartment (n=52 (30 female), 1...
January 4, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28063649/biologic-drugs-as-analgesics-for-the-management-of-osteoarthritis
#8
REVIEW
Theodoros Dimitroulas, Tosin Lambe, Rainer Klocke, George D Kitas, Rui V Duarte
BACKGROUND: Biologic drugs are novel therapeutic agents with demonstrated effectiveness in the management of a variety of chronic inflammatory disorders. Unmet needs in the treatment of chronic pain have led physicians to utilize a similar approach to patients suffering from conditions not characterized by systemic inflammation such as osteoarthritis (OA). The aim of this review is to discuss the current knowledge on the use of commonly used biologic agents [i.e., anti-tumor necrosis factor alpha (anti-TNF alpha) and anti-nerve growth factor (anti-NGF)] for the management of OA...
December 5, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28063212/regulation-of-chondrocyte-functions-by-transient-receptor-potential-cation-channel-v6-in-osteoarthritis
#9
Tengfei Song, Jun Ma, Lei Guo, Peng Yang, Xuhui Zhou, Tianwen Ye
Transient receptor potential vanilloid (TRPV) channels function to maintain the dynamic balance of calcium signaling and calcium metabolism in bones. The goal of this study was to determine the potential role of TRPV6 in regulation of chondrocytes. The level of TRPV6 expression was analyzed by western blot in articular cartilage derived from the knee joints of osteoarthritis (OA) rat models and OA patients. Bone structure and osteoarthritic changes in the knee joints of TRPV6 knockout mice were examined using micro-computed and histological analysis at the age of 6 and 12 months old...
January 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28060784/differences-in-clinical-pain-and-experimental-pain-sensitivity-between-asian-americans-and-whites-with-knee-osteoarthritis
#10
Hyochol Ahn, Michael Weaver, Debra E Lyon, Junglyun Kim, Eunyoung Choi, Roland Staud, Roger B Fillingim
OBJECTIVE: Ethnicity has been associated with clinical and experimental pain responses. Whereas ethnic disparities in pain in other minority groups compared with whites are well described, pain in Asian Americans remains poorly understood. The purpose of this study was to characterize differences in clinical pain intensity and experimental pain sensitivity among older Asian American and non-Hispanic white (NHW) participants with knee osteoarthritis (OA). METHODS: Data were collected from 50 Asian Americans ages 45 to 85 (28 Korean, 9 Chinese, 7 Japanese, 5 Filipino, and 1 Indian) and compared with 50 age-matched and sex-matched NHW individuals with symptomatic knee OA pain...
February 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28057326/meniscus-morphology-does-tear-type-matter-a-narrative-review-with-focus-on-relevance-for-osteoarthritis-research
#11
REVIEW
Mohamed Jarraya, Frank W Roemer, Martin Englund, Michel D Crema, Heather I Gale, Daichi Hayashi, Jeffrey N Katz, Ali Guermazi
OBJECTIVE: To give a narrative overview of meniscal tears with a radiologic emphasis on the morphologic type, technical considerations, and on the relevance of the type of meniscal tear in the context of osteoarthritis (OA) research. DESIGN: Total 20 years of the PubMed database were searched for epidemiological, radiological, arthroscopic and biomechanical reports, and review articles focusing on meniscal tears in middle-aged and older individuals, in the setting of OA...
November 24, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28056936/a-12-week-randomized-double-blind-placebo-controlled-multicenter-study-of-choline-stabilized-orthosilicic-acid-in-patients-with-symptomatic-knee-osteoarthritis
#12
Piet Geusens, Karel Pavelka, Jozef Rovensky, Johan Vanhoof, Nathalie Demeester, Mario Calomme, Dirk Vanden Berghe
BACKGROUND: The aim of this study was to assess the efficacy of choline-stabilized orthosilicic acid (ch-OSA) in patients with symptomatic knee osteoarthritis (OA). METHODS: In a multicenter, double-blind, placebo-controlled study, 211 patients with knee OA (Kellgren and Lawrence grade II or III) and moderate to moderately severe pain were randomly allocated to ch-OSA or placebo for 12 weeks. The primary outcome was the change in the WOMAC pain subscale from baseline to week 12...
January 5, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28056287/-the-fees-of-patients-with-knee-osteoarthritis
#13
K Wang, X Dong, J H Lin
Objective: To assess the cost of illness, the current medication treatment status and health service utilization of patients with knee osteoarthritis (OA). Methods: From January 2014 to May 2015, 250 patients in Arthritis Clinic and Research Center, Peking University People's Hospital were recruited and followed up for 12 months. There were four visits during the follow-up, i. e. baseline, 1, 6 and 12 month. Data on sociodemographic variables, direct cost of illness, medication utilization and health service utilization were obtained by the questionnaire for the analyses...
January 3, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28051248/movardol%C3%A2-n-acetylglucosamine-boswellia-serrata-ginger-supplementation-in-the-management-of-knee-osteoarthritis-preliminary-results-from-a-6-month-registry-study
#14
G Bolognesi, G Belcaro, B Feragalli, U Cornelli, R Cotellese, S Hu, M Dugall
OBJECTIVE: Knee Osteoarthritis (OA) is a chronic disease caused by the deterioration of cartilage in joints, which results in activation of the inflammatory response, pain, and impaired movement. Complementary therapies, particularly supplementation, in the management of moderate/severe knee OA have been gaining attention. This registry study aimed at evaluating the synergistic effect of Movardol®, a supplementation containing active ingredients with recognized anti-inflammatory activities on symptoms and levels of circulating biomarkers of knee OA...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28049462/new-herbal-composition-oa-f2-protects-cartilage-degeneration-in-a-rat-model-of-collagenase-induced-osteoarthritis
#15
Pallavi S Nirmal, Suresh D Jagtap, Aarti N Narkhede, Bhagyashri E Nagarkar, Abhay M Harsulkar
BACKGROUND: Prevalence of osteoarthritis (OA) is on rise on the global scale. At present there are no satisfactory pharmacological agents for treating OA. Our previous study showed that Sida cordifolia L. and Zingiber officinale Rosc. had protective effect on cartilage. Here, we describe the effect of OA-F2, a herbal formulation prepared using combination of these two plants in alleviating OA associated symptoms in a rat model of collagenase-induced OA. METHODS: OA was induced by intra-articular injection of collagenase type II in wistar rats...
January 3, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28043939/associations-among-meniscal-damage-meniscal-symptoms-and-knee-pain-severity
#16
Lindsey A MacFarlane, Heidi Yang, Jamie E Collins, Ali Guermazi, Morgan H Jones, Erin Teeple, Li Xu, Elena Losina, Jeffrey N Katz
OBJECTIVE: Meniscal tears occur frequently in patients with knee osteoarthritis (OA). The aim of our study was to determine whether meniscal damage identified on magnetic resonance imaging (MRI) is associated with the severity of knee pain or the frequency of meniscal symptoms in patients with knee OA. METHODS: We performed a cross-sectional study using data from the Meniscal Tear in Osteoarthritis Research (MeTeOR) trial. We characterized meniscal damage hierarchically as: root tear; maceration; long and short complex or horizontal tears; and simple tears...
December 30, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28043937/efficacy-and-safety-of-duloxetine-in-chinese-patients-with-chronic-pain-due-to-osteoarthritis-a-randomized-double-blind-placebo-controlled-study
#17
Guochun Wang, LiQi Bi, Xiangpei Li, Zhijun Li, Dongbao Zhao, Jinwei Chen, Dongyi He, Chia-Ning Wang, Héctor Dueñas, Vladimir Skljarevski, Li Yue
OBJECTIVE: We assessed the efficacy and safety of duloxetine (60 mg, once daily), compared with placebo, during a 13-week treatment period in Chinese patients with chronic pain due to osteoarthritis (OA). DESIGN: Patients were at least 40 years old (male or female) who met American College of Rheumatology clinical and radiographic criteria for the diagnosis of OA of the knee or hip. The primary efficacy measure in this phase 3, randomized, double-blind, placebo-controlled clinical trial was assessment of pain severity by the Brief Pain Inventory (BPI) 24-hour Average Pain rating...
December 30, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28042326/exosomes-derived-from-mir-140-5p-overexpressing-human-synovial-mesenchymal-stem-cells-enhance-cartilage-tissue-regeneration-and-prevent-osteoarthritis-of-the-knee-in-a-rat-model
#18
Shi-Cong Tao, Ting Yuan, Yue-Lei Zhang, Wen-Jing Yin, Shang-Chun Guo, Chang-Qing Zhang
OBJECTIVES: Osteoarthritis (OA) is the most common joint disease throughout the world. Exosomes derived from miR-140-5p-overexpressing synovial mesenchymal stem cells (SMSC-140s) may be effective in treating OA. We hypothesized that exosomes derived from SMSC-140 (SMSC-140-Exos) would enhance the proliferation and migration abilities of articular chondrocytes (ACs) without harming extracellular matrix (ECM) secretion. METHODS: SMSCs were transfected with or without miR-140-5p...
2017: Theranostics
https://www.readbyqxmd.com/read/28041596/clinical-settings-in-knee-osteoarthritis-pathophysiology-guides-treatment
#19
REVIEW
Gabriel Herrero-Beaumont, Jorge A Roman-Blas, Olivier Bruyère, Cyrus Cooper, John Kanis, Stefania Maggi, René Rizzoli, Jean-Yves Reginster
Osteoarthritis (OA) is the most common chronic joint disorder and its prevalence increases rapidly during midlife. Complex interactions of genetic alterations, sex hormone deficit, and aging with mechanical factors and systemic inflammation-associated metabolic syndrome lead to joint damage. Thus, the expression of a clinical phenotype in the early stages of OA relies on the main underlying pathway and predominant joint tissue involved at a given time. Moreover, OA often coexists with other morbidities in the same patient, which in turn condition the OA process...
February 2017: Maturitas
https://www.readbyqxmd.com/read/28040083/a-novel-aragonite-based-scaffold-for-osteochondral-regeneration-early-experience-on-human-implants-and-technical-developments
#20
Elizaveta Kon, Dror Robinson, Peter Verdonk, Matej Drobnic, Jenel Mariano Patrascu, Oliver Dulic, Gordon Gavrilovic, Giuseppe Filardo
INTRODUCTION: Chondral and osteochondral lesions represent a debilitating disease. Untreated lesions remain a risk factor for more extensive joint damage. The objective of this clinical study is to evaluate safety and early results of an aragonite-based scaffold used for osteochondral unit repair, by analysing both clinical outcome and MRI results, as well as the benefits of the procedure optimization through novel tapered shaped implants. METHODS: A crystalline aragonite bi-phasic scaffold was implanted in patients affected by focal chondral-osteochondral knee lesions of the condyle and trochlea...
December 2016: Injury
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