keyword
MENU ▼
Read by QxMD icon Read
search

Knee OA

keyword
https://www.readbyqxmd.com/read/27913970/radiological-and-biochemical-effects-ctx-ii-mmp-3-8-and-13-of-low-level-laser-therapy-lllt-in-chronic-osteoarthritis-in-al-kharj-saudi-arabia
#1
Gopal Nambi S, Walid Kamal, Julie George, Elbagir Manssor
Inflammation of synovial membrane and degeneration of articular cartilage in osteoarthritis (OA) lead to major changes in joint space width (JSW) and biochemical components such as collagen-II telopeptide (CTX-II) and matrix metallo protineases (MMP-3, 8, and 13). Low-level laser therapy (LLLT) is thought to have an analgesic effect as well as biomodulatory effect on microcirculation and cartilage regeneration in animal studies. The objective of this study was to examine the analgesic and biochemical effect of LLLT in patients with knee osteoarthritis...
December 3, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27913870/managing-knee-osteoarthritis-with-yoga-or-aerobic-strengthening-exercise-programs-in-older-adults-a-pilot-randomized-controlled-trial
#2
Corjena Cheung, Jean F Wyman, Ulf Bronas, Teresa McCarthy, Kyle Rudser, Michelle A Mathiason
Although exercise is often recommended for managing osteoarthritis (OA), limited evidence-based exercise options are available for older adults with OA. This study compared the effects of Hatha yoga (HY) and aerobic/strengthening exercises (ASE) on knee OA. Randomized controlled trial with three arms design was used: HY, ASE, and education control. Both HY and ASE groups involved 8 weekly 45-min group classes with 2-4 days/week home practice sessions. Control group received OA education brochures and weekly phone calls from study staff...
December 2, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27911916/incidence-of-deep-vein-thrombosis-and-venous-thromboembolism-following-tka-in-rheumatoid-arthritis-versus-osteoarthritis-a-meta-analysis
#3
Do-Kyung Lee, Hyun-Jung Kim, Dae-Hee Lee
This meta-analysis was designed to compare the incidence of deep vein thrombosis (DVT) and venous thromboembolism (VTE) following total knee arthroplasty (TKA) in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). All studies directly comparing the post-TKA incidence of DVT and/or VTE in patients with RA and OA were included. For all comparisons, odds ratios and 95% confidence intervals (CI) were calculated for binary outcomes. Six studies were included in the meta-analysis. The pooled data showed that the combined rates of asymptomatic and symptomatic DVT did not differ significantly in the RA and OA groups (1065/222,714 [0...
2016: PloS One
https://www.readbyqxmd.com/read/27910738/cartilage-repair-in-the-degenerative-ageing-knee
#4
Mats Brittberg, Andreas H Gomoll, José A Canseco, Jack Far, Martin Lind, James Hui
Background and purpose - Cartilage damage can develop due to trauma, resulting in focal chondral or osteochondral defects, or as more diffuse loss of cartilage in a generalized organ disease such as osteoarthritis. A loss of cartilage function and quality is also seen with increasing age. There is a spectrum of diseases ranging from focal cartilage defects with healthy surrounding cartilage to focal lesions in degenerative cartilage, to multiple and diffuse lesions in osteoarthritic cartilage. At the recent Aarhus Regenerative Orthopaedics Symposium (AROS) 2015, regenerative challenges in an ageing population were discussed by clinicians and basic scientists...
December 2, 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/27909787/test-retest-reliability-of-tibiofemoral-joint-space-width-measurements-made-using-a-low-dose-standing-ct-scanner
#5
Neil A Segal, John Bergin, Andrew Kern, Christian Findlay, Donald D Anderson
OBJECTIVE: To determine the test-retest reliability of knee joint space width (JSW) measurements made using standing CT (SCT) imaging. SUBJECTS AND METHODS: This prospective two-visit study included 50 knees from 30 subjects (66% female; mean ± SD age 58.2 ± 11.3 years; BMI 29.1 ± 5.6 kg/m(2); 38% KL grade 0-1). Tibiofemoral geometry was obtained from bilateral, approximately 20° fixed-flexed SCT images acquired at visits 2 weeks apart. For each compartment, the total joint area was defined as the area with a JSW <10 mm...
December 1, 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27909359/oa-go-away-development-and-preliminary-validation-of-a-self-management-tool-to-promote-adherence-to-exercise-and-physical-activity-for-people-with-osteoarthritis-of-the-hip-or-knee
#6
Gail Paterson, Karine Toupin April, Catherine Backman, Peter Tugwell
Purpose: To determine the face and content validity, construct validity, and test-retest reliability of the OA Go Away (OGA), a personalized self-management tool to promote adherence to exercise and physical activity for people with osteoarthritis (OA) of the hip or knee. Methods: The face and content validity of OGA version 1.0 were determined via interviews with 10 people with OA of the hip or knee and 10 clinicians. A revised OGA version 2.0 was then tested for construct validity and test-retest reliability with a new sample of 50 people with OA of the hip or knee by comparing key items in the OGA journal with validated outcome measures assessing similar health outcomes and comparing scores on key items of the journal 4-7 days apart...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27909144/bone-area-provides-a-responsive-outcome-measure-for-bone-changes-in-short-term-knee-osteoarthritis-studies
#7
Michael A Bowes, Rose A Maciewicz, John C Waterton, David J Hunter, Philip G Conaghan
OBJECTIVE: To analyze the 3-D bone area from an osteoarthritis (OA) cohort demonstrating no change in cartilage thickness. METHODS: Twenty-seven women with painful medial knee OA had magnetic resonance images at 0, 3, and 6 months. Images were analyzed using active appearance models. RESULTS: At 3 and 6 months, the mean change in medial femoral bone area was 0.34% (95% CI 0.04-0.64) and 0.61% (95% CI 0.32-0.90), respectively. Forty-one percent of the subjects had progression greater than the smallest detectable difference at 6 months...
December 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27909143/interobserver-and-intraobserver-reliability-of-clinical-assessments-in-knee-osteoarthritis
#8
Nasimah Maricar, Michael J Callaghan, Matthew J Parkes, David T Felson, Terence W O'Neill
OBJECTIVE: Clinical examination of the knee is subject to measurement error. The aim of this analysis was to determine interobserver and intraobserver reliability of commonly used clinical tests in patients with knee osteoarthritis (OA). METHODS: We studied subjects with symptomatic knee OA who were participants in an open-label clinical trial of intraarticular steroid therapy. Following standardization of the clinical test procedures, 2 clinicians assessed 25 subjects independently at the same visit, and the same clinician assessed 88 subjects over an interval period of 2-10 weeks; in both cases prior to the steroid intervention...
December 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27909124/predicting-dissatisfaction-following-total-knee-arthroplasty-in-patients-under-55-years-of-age
#9
C E H Scott, W M Oliver, D MacDonald, F A Wade, M Moran, S J Breusch
AIMS: Risk of revision following total knee arthroplasty (TKA) is higher in patients under 55 years, but little data are reported regarding non-revision outcomes. This study aims to identify predictors of dissatisfaction in these patients. PATIENTS AND METHODS: We prospectively assessed 177 TKAs (157 consecutive patients, 99 women, mean age 50 years; 17 to 54) from 2008 to 2013. Age, gender, implant, indication, body mass index (BMI), social deprivation, range of movement, Kellgren-Lawrence (KL) grade of osteoarthritis (OA) and prior knee surgery were recorded...
December 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27908189/thermoacoustic-imaging-of-rabbit-knee-joints
#10
Zihui Chi, Yuan Zhao, Lin Huang, Zhu Zheng, Huabei Jiang
PURPOSE: Knee joint is one of the largest and most complex joints of the body. Knee joint diseases are common, and current clinical imaging technologies such as x-ray computed tomography, magnetic resonance imaging, and ultrasound imaging have limitations in the diagnosis of knee joint diseases. Emerging imaging technologies such as diffuse optical tomography and photoacoustic imaging (PAI) have been applied to the detection of osteoarthritis (OA). However, they are limited to small joints such as the finger and difficult to be used for large joints such as the knee...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27904997/pleiotrophin-the-angiogenic-and-mitogenic-growth-factor-levels-in-serum-and-synovial-fluid-in-rheumatoid-arthritis-and-osteoarthritis-and-correlation-with-clinical-laboratory-and-radiological-indices
#11
S M H Fadda, I H Bassyouni, R H Khalifa, N Y Elsaid
BACKGROUND: Few studies have reported a possible involvement of pleiotrophin (PTN) in the pathophysiology of osteoarthritis (OA) and very little is known about its role in rheumatoid arthritis (RA). This study is to measure PTN in the sera and synovial fluids in RA and OA and to assess its relation to activity, functional class and radiological staging. SUBJECTS AND METHODS: Serum and synovial fluid samples were collected from 35 RA patients and 40 knee OA patients and serum samples were withdrawn from 20 healthy controls...
November 30, 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/27901480/timp-2-snps-rs7342880-and-rs4789936-are-linked-to-risk-of-knee-osteoarthritis-in-the-chinese-han-population
#12
Pengcheng Xu, Wen Guo, Tianbo Jin, Jihong Wang, Dongsheng Fan, Zengtao Hao, Shangfei Jing, Chao-Qian Han, Jieli Du, Dong Jiang, Shuzheng Wen, Jianzhong Wang
This study aimed to investigate whether functional polymorphisms in the tissue inhibitors of metalloproteinase-2 (TIMP-2) gene are associated with susceptibility to knee osteoarthritis (OA) in the Chinese Han population. Six TIMP-2 single nucleotide polymorphisms (SNPs) were assayed using MassARRAY in 300 patients clinically and radiographically diagnosed with knee OA and in 428 controls. Allelic and genotypic frequencies were compared between groups. Logistic regression adjusting for age and gender was used to estimate risk associations between specific genotypes and knee OA by computing odds ratios (ORs) and 95% confidence intervals (95% CIs)...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27900195/knee-osteoarthritis-in-traumatic-knee-symptoms-in-general-practice-6-year-cohort-study
#13
Marlous Kastelein, Pim A J Luijsterburg, Ingrid M Koster, Jan A N Verhaar, Bart W Koes, Dammis Vroegindeweij, Sita M A Bierma-Zeinstra, Edwin H G Oei
AIM: To identify degenerative knee abnormalities using MRI and radiography 6 years after knee trauma, their relation with persistent knee symptoms and baseline prognostic factors. METHODS: Adults (18-65 years) with incident traumatic knee symptoms visiting their general practitioner were followed up for 6 years and underwent baseline MRI and 6-year follow-up MRI and radiography. Logistic regression was used to analyse associations between various degenerative abnormalities on 6-year MRI and radiography, persistent knee symptoms and baseline prognostic factors for knee osteoarthritis (OA) on 6-year MRI...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27898461/cold-pain-threshold-identifies-a-subgroup-of-patients-with-knee-osteoarthritis-that-present-with-multimodality-hyperalgesia-and-elevated-pain-levels
#14
Anthony Wright, Heather A E Benson, Rob Will, Penny Moss
OBJECTIVES: Cold hyperalgesia has been established as an important marker of pain severity in a number of conditions. This study aimed to establish the extent to which patients with knee osteoarthritis (OA) demonstrate widespread cold, heat, and pressure hyperalgesia. OA participants with widespread cold hyperalgesia were compared with the remaining OA cohort to determine whether they could be distinguished in terms of hyperalgesia, pain report, pain quality, and physical function. METHODS: A total of 80 participants with knee OA and 40 matched healthy controls participated...
November 24, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27898457/ethnicity-cortisol-and-experimental-pain-responses-among-persons-with-symptomatic-knee-osteoarthritis
#15
Matthew S Herbert, Burel R Goodin, Hailey W Bulls, Adriana Sotolongo, Megan E Petrov, Jeffrey C Edberg, Laurence A Bradley, Roger B Fillingim
OBJECTIVES: While several factors are known to contribute to ethnic differences in pain, relatively little attention has been devoted to physiological factors. Our first aim was to examine the relationship between cortisol and pain responses during a cold-pressor task (CPT) among African American (AA) and non-Hispanic White (NHW) adults with knee osteoarthritis (OA). Our second aim was to assess the relationship between perceived racial discrimination and cortisol among AA participants...
November 28, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27896800/principal-component-analysis-in-the-evaluation-of-osteoarthritis
#16
Stephanie E Calce, Helen K Kurki, Darlene A Weston, Lisa Gould
OBJECTIVES: The purpose of this study is to demonstrate advantages of principal component analysis (PCA) as a standardized procedure in the evaluation of osteoarthritis (OA) in a skeletal series to: (1) compute aggregate scores for joint complexes that accurately capture pathological expression, (2) reveal which variables describe the most sample variation in OA, (3) enable inter- and intra-sample comparison of results, and (4) formulate predictive models from component-based arthritic scores...
November 29, 2016: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27895439/comparison-of-two-different-molecular-weight-intra-articular-injections-of-hyaluronic-acid-for-the-treatment-of-knee-osteoarthritis
#17
I Gigis, E Fotiadis, A Nenopoulos, K Tsitas, I Hatzokos
BACKGROUND: Knee osteoarthritis (OA) is an incurable joint disorder, representing a major public health issue. Among options for symptom control, viscosupplementation with hyaluronic acid (HA) had established usefulness in pain and function improvement of the knee. However, it is not clear which form of HA yields better results. MATERIAL AND METHODS: We compared two HA preparations with high (HMW) or low molecular weight (LMW) in terms of pain control and function improvement using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the visual analog scale (VAS) score in patients with knee OA...
January 2016: Hippokratia
https://www.readbyqxmd.com/read/27894935/brief-report-stage-specific-differences-in-secretory-profile-of-mesenchymal-stromal-cells-mscs-subjected-to-early-vs-late-stage-oa-synovial-fluid
#18
Alejandro Gómez-Aristizábal, Anirudh Sharma, Mohsen A Bakooshli, Mohit Kapoor, Penney M Gilbert, Sowmya Viswanathan, Rajiv Gandhi
OBJECTIVE: Although, mesenchymal stromal cells (MSCs) are being clinically investigated for their use in osteoarthritis (OA), it is unclear whether their postulated therapeutic properties are equally effective in the early- and late-stages of OA. In this study we investigated MSC cytokine secretion post-exposure to synovial fluid (SF), obtained from early-vs. late-stage knee OA patients to justify a potential patient stratification strategy to maximize MSC-mediated treatment effects. METHOD: Subjects were recruited and categorized into early- [Kellgren-Lawrence (KL) grade I/II, n = 12] and late-stage (KL-III/IV, n = 12) knee OA groups...
November 25, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27893033/effect-of-a-decision-aid-on-access-to-total-knee-replacement-for-black-patients-with-osteoarthritis-of-the-knee-a-randomized-clinical-trial
#19
Said A Ibrahim, Marissa Blum, Gwo-Chin Lee, Pekka Mooar, Elina Medvedeva, Aliya Collier, Diane Richardson
Importance: Black patients with advanced osteoarthritis (OA) of the knee are significantly less likely than white patients to undergo surgery. No strategies have been proved to improve access to surgery for black patients with end-stage OA of the knee. Objective: To assess whether a decision aid improves access to total knee replacement (TKR) surgery for black patients with OA of the knee. Design, Setting, and Participants: In a randomized clinical trial, 336 eligible participants who self-identified as black and 50 years or older with chronic and frequent knee pain, a Western Ontario McMaster Universities Osteoarthritis Index score of at least 39, and radiographic evidence of OA of the knee were recruited from December 1, 2010, to May 31, 2014, at 3 medical centers...
November 23, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27891668/systematic-mapping-of-the-subchondral-bone-3d-microarchitecture-in-the-human-tibial-plateau-variations-with-joint-alignment
#20
Bryant C Roberts, Dominic Thewlis, Lucian B Solomon, Graham Mercer, Karen J Reynolds, Egon Perilli
Tibial subchondral bone plays an important role in knee osteoarthritis (OA). Microarchitectural characterization of subchondral bone plate (SBP), underlying subchondral trabecular bone (STB) and relationships between these compartments, however, is limited. The aim of this study was to characterize the spatial distribution of SBP thickness, SBP porosity and STB microarchitecture, and relationships among them, in OA tibiae of varying joint alignment. Twenty-five tibial plateaus from end-stage knee-OA patients, with varus (n = 17) or non-varus (n = 8) alignment were micro-CT scanned (17 μm/voxel)...
November 7, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
keyword
keyword
42931
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"