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https://www.readbyqxmd.com/read/28334196/the-effectiveness-of-prolotherapy-in-treating-knee-osteoarthritis-in-adults-a-systematic-review
#1
Fadi Hassan, Suad Trebinjac, William D Murrell, Nicola Maffulli
Introduction: Osteoarthritis (OA) often leads to symptoms such as pain, stiffness and decreased function. OA is treated with a wide range of modalities, both conservatively and surgically. Prolotherapy has been used to treat various musculoskeletal problems and has shown some promise. Sources of data: Searches of the electronic databases, PubMed, ISI web of science, PEDro and SPORTDiscus, were conducted for all Level 1-4 studies published from inception through to December 2016...
March 4, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28333699/biomarker-of-extracellular-matrix-remodelling-c1m-and-proinflammatory-cytokine-il-6-are-related-to-synovitis-and-pain-in-endstage-knee-osteoarthritis-patients
#2
Maja R Radojčić, Christian S Thudium, Kim Henriksen, Keith Tan, Rolf Karlsten, Amanda Dudley, Iain Chessell, Morten A Karsdal, Anne-Christine Bay-Jensen, Michel D Crema, Ali Guermazi
Little is known about local and systemic biomarkers in relation to synovitis and pain in end-stage osteoarthritis (OA) patients. We investigated the associations between the novel extracellular matrix biomarker, C1M, and local and systemic interleukin 6 (IL-6) with synovitis and pain. Serum C1M, plasma and synovial fluid IL-6 (p-IL-6, sf-IL-6) were measured in 104 end-stage knee OA patients. Contrast-enhanced magnetic resonance imaging (MRI) was used to semi-quantitatively assess an 11-point synovitis score; pain was assessed by the Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC) and the Neuropathic Pain Questionnaire (NPQ)...
March 22, 2017: Pain
https://www.readbyqxmd.com/read/28332780/differentiation-of-patented-crystalline-glucosamine-sulfate-from-other-glucosamine-preparations-will-optimize-osteoarthritis-treatment
#3
REVIEW
Sukit Saengnipanthkul, Saranatra Waikakul, Sattaya Rojanasthien, Kitti Totemchokchyakarn, Attarit Srinkapaibulaya, Tai Cheh Chin, Nguyen Mai Hong, Olivier Bruyère, Cyrus Cooper, Jean-Yves Reginster, Myat Lwin
Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) are recommended for the medium- to long-term management of knee osteoarthritis (OA) due to their abilities to control pain, improve function and delay joint structural changes. Among SYSADOAs, evidence is greatest for the patented crystalline glucosamine sulfate (pCGS) formulation (Mylan). Glucosamine is widely available as glucosamine sulfate (GS) and glucosamine hydrochloride (GH) preparations that vary substantially in molecular form, pharmaceutical formulation and dose regimen...
March 23, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28330798/knee-osteoarthritis-degenerative-meniscal-lesion-and-osteonecrosis-of-the-knee-can-a-simple-gait-test-direct-us-to-a-better-clinical-diagnosis
#4
Ronen Debi, Avi Elbaz, Amit Mor, Gadi Kahn, Bezalel Peskin, Yiftah Beer, Gabriel Agar, Guy Morag, Ganit Segal
INTRODUCTION: The purpose of the current study was to compare the gait patterns in patients with three differing knee pathologies - knee osteoarthritis (OA), degenerative meniscal lesion (DML) and spontaneous osteonecrosis of the knee (SONK) and a group of healthy controls. HYPOTHESIS: A simple gait test will detect differences between different knee pathologies. MATERIAL AND METHODS: Forty-seven patients with bilateral knee OA, 47 patients with DML, 28 patients with SONK and 27 healthy controls were included in this analysis...
March 19, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28328935/intra-articular-hyaluronic-acid-in-the-management-of-knee-osteoarthritis-pharmaco-economic-study-from-the-perspective-of-the-national-health-insurance-system
#5
Thierry Thomas, Françoise Amouroux, Patrice Vincent
INTRODUCTION: Pharmaco-economic data on the management of knee osteoarthritis (OA) with intra articular hyaluronic acid (IA HA) viscosupplementation is limited. We contrasted IA HA with non-steroidal anti-inflammatory drugs (NSAIDs). METHODS: Observational, prospective and multicenter study comparing treatments of knee OA costs and efficacy with either NSAIDs alone, or hyaluronic acid (Arthrum H 2%®), during a 6-month follow-up period. The investigators were pharmacists who recorded data on disease, drug consumption and healthcare circuit...
2017: PloS One
https://www.readbyqxmd.com/read/28326422/late-hemorrhagic-pseudoseptic-arthritis-encountered-during-total-knee-arthroplasty-due-to-hyaluronic-acid-viscosupplementation
#6
Jeremy M Korsh, William Paul Bassett, Donald R Polakoff
Osteoarthritis (OA) is the most common form of arthritis and affects approximately one-third of people in the United Sates aged 65 years and older. Since 2013, the American Academy of Orthopaedic Surgeons has not been able to recommended using hyaluronic acid for patients with symptomatic OA of the knee. Subsequent publications have also cautioned against the use of viscosupplementation based on lack of efficacy and the potential for harm. We present a case of late hemorrhagic pseudoseptic arthritis encountered during TKA due to hyaluronic acid viscosupplementation...
December 2016: Arthroplasty Today
https://www.readbyqxmd.com/read/28326213/a-fatal-sepsis-caused-by-hyaluronate-knee-injection-how-much-the-medical-history-and-the-informed-consent-might-be-important
#7
F Manfreda, G Rinonapoli, A Nardi, P Antinolfi, A Caraffa
The incidence of Osteoarthritis (OA) is gradually increasing worldwide due to two main reasons: longer life expectation and increased functional demand. Several treatment options have been proposed for this disease. Conservative treatment has the goal to improve the quality of life, reduce pain, and prevent the progression of the disease. Hyaluronate viscosupplementation is one of the most used infiltrative treatments for OA, but, despite its common use, clinical efficacy is still under question. Though adverse reactions for this medical option are actually rare, septic arthritis is a very scaring complication...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28325340/low-molecular-weight-xanthan-gum-for-treating-osteoarthritis
#8
Guanying Han, Qixin Chen, Fei Liu, Zan Cui, Huarong Shao, Fuyan Liu, Aibin Ma, Joshua Liao, Bin Guo, Yuewei Guo, Fengshan Wang, Peixue Ling, Xifan Mei
Osteoarthritis (OA) is one of the most common chronic diseases and characterized by degradation of articular cartilage. We have previously reported xanthan gum (XG) injection preparation with high molecular weights (Mw) in ranging from 3×10(6)Da to 5×10(6)Da (HM-XG) could enhance the viscosity of synovial fluid, protect joint cartilage in rabbit, and the therapeutical effect has no significance difference with an existing clinical medication (sodium hyaluronate, SH) at the same injection frequency (once weekly for 5 weeks)...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28322719/prp-in-oa-knee-update-current-confusions-and-future-options
#9
Mandeep S Dhillon, Sandeep Patel, Rakesh John
Positive results have been uniformly observed by various researchers for platelet-rich plasma (PRP) in early osteoarthritis (OA) knee in the past few years. PRP has clearly demonstrated its supremacy in comparison to hyaluronic acid (HA) and placebo in various clinical trials and is undoubtedly the best option available for symptomatic treatment in early OA. The release of growth factors from PRP occurs immediately and lasts for around three weeks and the clinical effect tends to wane down by the end of the year...
2017: SICOT-J
https://www.readbyqxmd.com/read/28321432/a-novel-implant-system-for-unloading-the-medial-compartment-of-the-knee-by-lateral-displacement-of-the-iliotibial-band
#10
Vivek N Shenoy, Hanson S Gifford, John T Kao
BACKGROUND: Medial knee osteoarthritis (OA) typically occurs with excessive mechanical load within the medial compartment, resulting in degeneration of the articular cartilage. PURPOSE: A novel extracapsular implant (Latella Knee Implant) has been developed to unload the medial compartment of the knee. The implant displaces the iliotibial band (ITB) over the lateral femoral condyle, thereby increasing its effective moment arm, resulting in a transfer of load from the medial compartment to the lateral compartment of the knee...
March 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28320529/prevalence-of-neuropathic-pain-in-knee-or-hip-osteoarthritis-a-systematic-review-and-meta-analysis
#11
REVIEW
Helen P French, Keith M Smart, Frank Doyle
OBJECTIVE: Discordance between radiographic and pain severity in osteoarthritis (OA) has led researchers to investigate other pain mechanisms, including neuropathic pain. Accurate identification of any neuropathic pain in hip or knee OA is important for appropriate management, but neuropathic pain prevalence is unknown. We aimed to obtain an overall prevalence estimate by systematically reviewing and meta-analysing the prevalence of neuropathic pain in people with hip or knee OA. METHOD: Observational studies which measured neuropathic pain in people aged 18 years and older with hip or knee OA were considered for inclusion...
February 20, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28320075/a-cost-utility-analysis-of-high-molecular-weight-hyaluronic-acid-for-knee-osteoarthritis-in-everyday-clinical-care-in-patients-in-the-working-age-an-economic-evaluation-of-a-randomized-clinical-trial
#12
Job Hermans, Max Reijman, Lucas Ma Goossens, Hennie Verburg, Sita Ma Bierma-Zeinstra, Marc A Koopmanschap
Objectives Knee osteoarthritis (OA) is associated with high medical costs and especially with high productivity costs, in particular in patients in their working years. High molecular weight (HMW) hyaluronic acid (HA) is an alternative treatment for non-steroidal anti-inflammatory drugs (NSAIDs), which are known for their serious side-effects. The cost-utility of intra-articular HMW-HA treatment in these patients is unknown though and was assessed in this study. Methods Secondary care patients between 18 and 65 with knee OA were randomized to usual care (UC) + HMW-HA (intervention group) or UC only (control group)...
March 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28320074/diagnostic-performance-of-clinical-examination-measures-and-pain-presentation-to-identify-patellofemoral-joint-osteoarthritis
#13
J J Stefanik, R Duncan, D T Felson, G Peat
OBJECTIVE: Test the diagnostic performance of a comprehensive set of tests and measures to discriminate patellofemoral (PF) from tibiofemoral (TF) osteoarthritis (OA). METHODS: The Clinical Assessment of the Knee Study is a study of knee pain in the general population. The presence of PF crepitus and pain with PF compression were assessed. Anterior knee pain (AKP) was determined from a knee pain map. Pain with stairs and walking on level ground were assessed with the WOMAC...
March 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28320059/effects-of-treadmill-exercise-on-advanced-osteoarthritis-pain-in-rats
#14
Joshua Allen, Ian Imbert, Joshua Havelin, Terry Henderson, Glenn Stevenson, Lucy Liaw, Tamara King
OBJECTIVE: Exercise is commonly recommended for patients with osteoarthritis (OA) pain. However, whether exercise is beneficial in ameliorating persistent NSAID-resistant ongoing pain associated with advanced OA is unknown. METHODS: Rats treated with intra-articular monosodium iodoacetate (MIA) or saline underwent treadmill exercise or remained sedentary starting 10 days post-injection. Tactile sensory thresholds and weight bearing were assessed followed by radiographs at weekly intervals...
March 20, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28320058/regional-differences-between-perisynovial-and-infrapatellar-adipose-tissue-depots-and-their-response-to-class-ii-and-iii-obesity-in-patients-with-oa
#15
Natalia S Harasymowicz, Nick D Clement, Asim Azfer, Richard Burnett, Donald M Salter, A Hamish W R Simpson
OBJECTIVE: Obesity is associated with an increased risk of developing Osteoarthritis (OA), which is postulated to be secondary to inflammation from adipose tissue (AT). There are peri-articular adipose depots in synovial joints, the association of this tissue with OA has not been extensively explored. The aim of this study was to investigate differences in local AT depots in knees with OA and changes related to class II and III obesity. METHODS: Synovium and the infrapatellar fat pad (IPFP) were collected during total knee replacement from 69 patients with end-stage OA...
March 20, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28320048/dynamic-effects-of-depressive-symptoms-on-osteoarthritis-knee-pain
#16
Alan M Rathbun, Elizabeth A Stuart, Michelle Shardell, Michelle S Yau, Mona Baumgarten, Marc C Hochberg
OBJECTIVE: To estimate the dynamic causal effects of depressive symptoms on osteoarthritis (OA) knee pain. METHODS: Marginal structural models were used to examine dynamic associations between depressive symptoms and pain over 48 months among older adults (n=2,287) with radiographic knee OA (Kellgren-Lawrence grade=2 or 3) in the Osteoarthritis Initiative. Depressive symptoms at each annual visit were assessed (threshold = ≥ 16) using the Center for Epidemiological Studies Depression Scale...
March 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28319157/subchondral-bone-histology-and-grading-in-osteoarthritis
#17
Olli-Matti Aho, Mikko Finnilä, Jerome Thevenot, Simo Saarakkala, Petri Lehenkari
OBJECTIVE: Osteoarthritis (OA) has often regarded as a disease of articular cartilage only. New evidence has shifted the paradigm towards a system biology approach, where also the surrounding tissue, especially bone is studied more vigorously. However, the histological features of subchondral bone are only poorly characterized in current histological grading scales of OA. The aim of this study is to specifically characterize histological changes occurring in subchondral bone at different stages of OA and propose a simple grading system for them...
2017: PloS One
https://www.readbyqxmd.com/read/28317389/prp-for-degenerative-cartilage-disease
#18
Lior Laver, Niv Marom, Lad Dnyanesh, Omer Mei-Dan, João Espregueira-Mendes, Alberto Gobbi
OBJECTIVE: To explore the utilization of platelet-rich plasma (PRP) for degenerative cartilage processes and evaluate whether there is sufficient evidence to better define its potential effects. DESIGN: Systematic literature reviews were conducted in PubMed/MEDLINE and Cochrane electronic databases till May 2015, using the keywords "platelet-rich plasma OR PRP OR autologous conditioned plasma OR ACP AND cartilage OR chondrocyte OR chondrogenesis OR osteoarthritis (OA) OR arthritis...
September 1, 2016: Cartilage
https://www.readbyqxmd.com/read/28304363/knee-viscosupplementation-cost-effectiveness-analysis-between-stabilized-hyaluronic-acid-in-a-single-injection-versus-five-injections-of-standard-hyaluronic-acid
#19
Francisco J Estades-Rubio, Alvaro Reyes-Martín, Victor Morales-Marcos, Mercedes García-Piriz, Juan J García-Vera, Macarena Perán, Juan A Marchal, Elvira Montañez-Heredia
Given the wide difference in price per vial between various presentations of hyaluronic acid, this study seeks to compare the effectiveness and treatment cost of stabilized hyaluronic acid (NASHA) in a single injection with standard preparations of hyaluronic acid (HA) in five injections in osteoarthritis (OA) of the knee. Fifty-four patients with knee osteoarthritis (Kellgren-Lawrence Grade II and III) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score greater than 7, with a homogeneous distribution of age, sex, BMI, and duration of disease, were included in this study...
March 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28303595/a-single-intra-articular-injection-of-fluvastatin-plga-microspheres-reduces-cartilage-degradation-in-rabbits-with-experimental-osteoarthritis
#20
Norio Goto, Ken Okazaki, Yukio Akasaki, Kohei Ishihara, Koji Murakami, Kiyoshi Koyano, Yasunori Ayukawa, Noriyuki Yasunami, Tomohiro Masuzaki, Yasuharu Nakashima
Statins are cholesterol-lowering drugs that inhibit 3-hydroxy-3- methylglutaryl-coenzyme A (HMG-CoA) reductase, a rate-limiting enzyme of the mevalonate pathway. The anti-inflammatory effect of statins has been reported in recent years. The present study investigated therapeutic effects of the local administration of statin in osteoarthritis (OA). We assessed clinically used statins and selected fluvastatin for further experimentation, as it showed potent anabolic and anti-catabolic effects on human OA chondrocytes...
March 17, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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