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https://www.readbyqxmd.com/read/28735021/wisp1-ccn4-aggravates-cartilage-degeneration-in-experimental-osteoarthritis
#1
Martijn H van den Bosch, Arjen B Blom, Vardit Kram, Azusa Maeda, Sheena Sikka, Yankel Gabet, Tina M Kilts, Wim B van den Berg, Peter L van Lent, Peter M van der Kraan, Marian F Young
OBJECTIVE: Increased Wisp1 expression was previously reported in experimental and human osteoarthritis. Moreover, adenoviral overexpression of Wisp1 in naïve mouse knee joints resulted in early OA-like cartilage lesions. Here, we determined how the matricellular protein WISP1 is involved in the pathology that occurs in the complex osteoarthritic environment with aging and experimental osteoarthritis in wild type and Wisp1(-/-) mice. METHODS: Wild type and Wisp1(-/-) mice were aged or experimental osteoarthritis was induced with intraarticular collagenase injection, destabilization of the medial meniscus or anterior cruciate ligament transection...
July 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28734667/characterization-of-cartilage-defects-detected-by-mri-in-kellgren-lawrence-grade-0-or-1-knees
#2
Kenji Taguchi, Ko Chiba, Narihiro Okazaki, Yasuo Kido, Takashi Miyamoto, Akihiko Yonekura, Masato Tomita, Masataka Uetani, Makoto Osaki
INTRODUCTION: Osteoarthritis of the knee is generally evaluated by plain X-rays, which are incapable of detecting small cartilage damage. There are some patients who have small cartilage defects on MRI with no abnormal findings on plain X-rays. In this study, the prevalence and regional characteristics of cartilage defects detected by MRI were studied in cases with normal X-ray findings (Kellgren-Lawrence grade 0 and 1). Relationships between the cartilage defects and OA risk factors such as obesity and leg alignment were also investigated...
July 19, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28728606/levels-of-serum-biomarkers-from-a-two-year-multicentre-trial-are-associated-with-treatment-response-on-knee-osteoarthritis-cartilage-loss-as-assessed-by-magnetic-resonance-imaging-an-exploratory-study
#3
Johanne Martel-Pelletier, Jean-Pierre Raynauld, François Mineau, François Abram, Patrice Paiement, Philippe Delorme, Jean-Pierre Pelletier
BACKGROUND: There is an obvious need to identify biomarkers that could predict patient response to an osteoarthritis (OA) treatment. This post hoc study explored in a 2-year randomized controlled trial in patients with knee OA, the likelihood of some serum biomarkers to be associated with a better response to chondroitin sulfate in reducing cartilage volume loss. METHODS: Eight biomarkers were studied: hyaluronic acid (HA), C reactive protein (CRP), adipsin, leptin, N-terminal propeptide of collagen IIα (PIIANP), C-terminal crosslinked telopeptide of type I collagen (CTX-1), matrix metalloproteinase-1 (MMP-1), and MMP-3...
July 20, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28728444/determinants-of-pain-disability-health-related-quality-of-life-and-physical-performance-in-patients-with-knee-osteoarthritis-awaiting-total-joint-arthroplasty
#4
Véronique Lowry, Philippe Ouellet, Pascal-André Vendittoli, Lisa C Carlesso, Timothy H Wideman, François Desmeules
PURPOSE: In patients suffering from knee osteoarthritis awaiting knee arthroplasty, to measure associations between several selected determinants and pain, disability, health-related quality of life and physical performance. MATERIAL AND METHODS: Validated self-reported measures were collected: (1) Western Ontario and McMaster Universities Osteoarthritis Index, (2) Lower Extremity Functional Scale (LEFS) and (3) Short-Form 36 (SF-36). Physical performance was also assessed with four validated performance tests...
July 20, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28726510/the-effect-of-probiotic-lactobacillus-casei-shirota-on-knee-osteoarthritis-a-randomised-double-blind-placebo-controlled-clinical-trial
#5
M Lei, C Guo, D Wang, C Zhang, L Hua
Knee osteoarthritis (OA) treatment is challenging due to inefficacy and adverse effects of current medications. Probiotic treatment has been shown to promote bone metabolism, reduce pain and inflammatory responses of age-related musculoskeletal disorders, including OA. We aimed to investigate the effect of probiotic Lactobacillus casei Shirota (LcS) on patients with knee OA. 537 patients with knee OA were enrolled in this double-blind, placebo-controlled trial, who were randomised to receive skimmed milk containing either LcS or placebo daily for 6 months...
July 20, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28725908/cyst-like-lesions-at-chondro-osseous-junction
#6
Zijun Zhang, Jeffrey Beckett, Lew Schon
This study described and histologically characterized a cyst-like lesion (CLL) at the chondro-osseous junction. Rat knees (n = 12), with or without excessive running-induced osteoarthritis (OA), were used for counting the incidence, morphological measurements, immunohistochemistry of the CLL. A typical CLL, appearing as a void space in the matrix, was located on the tidemark at the chondro-osseous junction. The content of the CLL included types II and VI collagen, proteoglycans but not intact chondrocytes. At least one CLL was found in 5/6 osteoarthritic knees and only 2/6 in the non-osteoarthritic knees...
July 19, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28723717/localized-muscle-vibration-reverses-quadriceps-muscle-hypotrophy-and-improves-physical-function-a-clinical-and-electrophysiological-study
#7
Maria Grazia Benedetti, Gennaro Boccia, Lorenzo Cavazzuti, Elena Magnani, Elisabetta Mariani, Alberto Rainoldi, Roberto Casale
Quadriceps weakness has been associated with knee osteoarthritis (OA). High-frequency localized muscle vibration (LMV) has been proposed recently for quadriceps strengthening in patients with knee OA. The purpose of this study was (a) to investigate the clinical effectiveness of high-frequency LMV on quadriceps muscle in patients with knee OA and (b) to disentangle, by means of surface electromyography (sEMG), the underlying mechanism. Thirty patients, aged between 40 and 65 years, and clinically diagnosed with knee OA were included in this randomized, controlled, single-blinded pilot study...
July 18, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28717804/relationship-between-total-fruit-and-vegetable-intake-and-self-reported-knee-pain-in-older-adults
#8
H S Han, C B Chang, D-C Lee, J-Y Lee
OBJECTIVES: Knee pain is one of the most common symptoms of knee osteoarthritis (OA) that affects the quality of life in the older adults, and identifying the contributing factors of knee pain is important. We hypothesized that higher fruit and vegetable consumption might be associated with the severity of knee pain lower prevalence of severe knee pain by affecting pain perception in the knee joint. Therefore, we investigated the relationship between self-reported knee pain and the consumption of fruits vegetables, carotenoids and vitamin C and self-reported knee pain...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28716535/variable-compensation-during-the-sit-to-stand-task-among-individuals-with-severe-knee-osteoarthritis
#9
Yoshimasa Sagawa, Alice Bonnefoy-Mazure, Stéphane Armand, Anne Lubbeke, Pierre Hoffmeyer, Domizio Suva, Katia Turcot
BACKGROUND: Individuals with knee osteoarthritis (OA) show variability during the sit-to-stand (STS) task, so they may not perform the STS in the same way. This study aimed to determine whether individuals with knee OA have different strategies in performing the STS. METHODS: Participants with knee OA and able-bodied individuals underwent STS evaluation at a self-selected pace with use of a motion measurement system consisting of 12 cameras and 2 force plates. RESULTS: In total, 101 participants (57 women) with knee OA showed 3 main STS strategies...
July 14, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28714028/identification-of-potential-target-genes-associated-with-the-pathogenesis-of-osteoarthritis-using-microarray-based-analysis
#10
Meng Li, Liqiang Zhi, Zhi Zhang, Weiguo Bian, Yusheng Qiu
The aim of the present study was to investigate the molecular circuitry of osteoarthritis (OA) and identify more potential target genes for OA treatment. Microarray data of GSE32317 was downloaded from the National Center for Biotechnology Information Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified in samples of synovial membrane from patients with early stage of knee OA (OA_Early) and late stage of knee OA (OA_End) that were compared with healthy specimens. Bioinformatics analysis was applied to analyze the significant functions and pathways that were enriched by the common DEGs identified in OA_Early and OA_End samples...
July 5, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28711767/fully-automated-subchondral-bone-segmentation-from-knee-mr-images-data-from-the-osteoarthritis-initiative
#11
Akash Gandhamal, Sanjay Talbar, Suhas Gajre, Ruslan Razak, Ahmad Fadzil M Hani, Dileep Kumar
Knee osteoarthritis (OA) progression can be monitored by measuring changes in the subchondral bone structure such as area and shape from MR images as an imaging biomarker. However, measurements of these minute changes are highly dependent on the accurate segmentation of bone tissue from MR images and it is challenging task due to the complex tissue structure and inadequate image contrast/brightness. In this paper, a fully automated method for segmenting subchondral bone from knee MR images is proposed. Here, the contrast of knee MR images is enhanced using a gray-level S-curve transformation followed by automatic seed point detection using a three-dimensional multi-edge overlapping technique...
July 8, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28711584/biomarkers-reflect-differences-in-osteoarthritis-phenotypes-of-the-lumbar-spine-the-johnston-county-osteoarthritis-project
#12
Adam P Goode, Amanda E Nelson, Virginia B Kraus, Jordan B Renner, Joanne M Jordan
OBJECTIVE: To determine differences in biomarker levels between radiographic phenotypes of facet joint osteoarthritis (FOA) only, spine OA only ((disc space narrowing (DSN) and vertebral osteophytes (OST)) or the combination of FOA and spine OA. DESIGN: A cross-sectional analysis of data from 555 participants in the Johnston County Osteoarthritis Project was performed. Lumbar spine levels were graded by severity (OST and DSN) and presence (FOA) of degeneration. Biomarkers included hyaluronan (HA) and type II collagen (CTX-II)...
July 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28711582/a-novel-wnt-pathway-inhibitor-sm04690-for-the-treatment-of-moderate-to-severe-osteoarthritis-of-the-knee-results-of-a-24-week-randomized-controlled-phase-1-study
#13
Yusuf Yazici, Timothy E McAlindon, Roy Fleischmann, Allan Gibofsky, Nancy E Lane, Alan J Kivitz, Nebojsa Skrepnik, Eddie Armas, Christopher J Swearingen, Anita DiFrancesco, Jeyanesh R S Tambiah, John Hood, Marc C Hochberg
OBJECTIVE: To assess the safety, pharmacokinetics, and exploratory efficacy of SM04690, a novel Wnt pathway inhibitor, as a potential disease modifying treatment for knee OA. DESIGN: Subjects with Kellgren-Lawrence grade 2-3 knee OA were randomized in successive dose-escalation cohorts to receive a knee intra-articular injection with 0.03, 0.07, or 0.23 mg SM04690, or placebo (PBO) (4:1 ratio). Safety, pharmacokinetics, efficacy (WOMAC Total/Function/Pain, Pain VAS, Physician Global Assessment [MDGA], and OMERACT-OARSI Response), OA-related biomarker (P1NP, ß-CTX, and COMP), and radiographic/imaging data were collected at baseline and during 24-week follow-up...
July 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28705915/microarray-analysis-of-bone-marrow-lesions-in-osteoarthritis-demonstrates-upregulation-of-genes-implicated-in-osteochondral-turnover-neurogenesis-and-inflammation
#14
Anasuya Kuttapitiya, Lena Assi, Ken Laing, Caroline Hing, Philip Mitchell, Guy Whitley, Abiola Harrison, Franklyn A Howe, Vivian Ejindu, Christine Heron, Nidhi Sofat
OBJECTIVE: Bone marrow lesions (BMLs) are well described in osteoarthritis (OA) using MRI and are associated with pain, but little is known about their pathological characteristics and gene expression. We evaluated BMLs using novel tissue analysis tools to gain a deeper understanding of their cellular and molecular expression. METHODS: We recruited 98 participants, 72 with advanced OA requiring total knee replacement (TKR), 12 with mild OA and 14 non-OA controls...
July 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28704603/relationship-between-knee-pain-and-infra-patellar-fat-pad-morphology-a-within-and-between-person-analysis-from-the-osteoarthritis-initiative
#15
Eva Steidle-Kloc, Adam G Culvenor, Jan Dörrenberg, Wolfgang Wirth, Anja Ruhdorfer, Felix Eckstein
OBJECTIVE: Inflammation is known to be strongly associated with knee pain in osteoarthritis. The infra-patellar fat pad represents a potential source of pro-inflammatory cytokines. Yet, the relationship between infra-patellar fat pad morphology and osteoarthritis symptoms is unclear. METHODS: Here we investigate quantitative imaging parameters of infra-patellar fat pad morphology between: a) painful vs. contralateral pain-free limbs of subjects with unilateral pain; and b) knees of patients with chronic knee pain vs...
July 13, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28699498/is-the-addition-of-a-polyol-to-hyaluronic-acid-a-significant-advance-in-the-treatment-of-osteoarthritis
#16
Thierry Conrozier
Viscosupplementation with intra-articular injections of hyaluronic acid is recommended as a second line treatment for knee OA, after failure of non-pharmacological modalities and usual pain killers. Nevertheless there is still controversies regarding clinical relevance of its effects. Research is looking at the best means to improve the performance of viscosupplementation in order to obtain a faster, more sustainable and more marked effect. Antioxidants have been assessed in combination with hyaluronic acid because the injected hyaluronate is rapidly degraded by the reactive oxygen species present in large amounts in the OA synovial fluid, limiting its residence time into the joint...
July 10, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28698105/magnetic-resonance-imaging-mri-defined-cartilage-degeneration-and-joint-pain-are-associated-with-poor-physical-function-in-knee-osteoarthritis-the-oulu-knee-osteoarthritis-study
#17
P Kaukinen, J Podlipská, A Guermazi, J Niinimäki, P Lehenkari, F W Roemer, M T Nieminen, J M Koski, S Saarakkala, J P A Arokoski
OBJECTIVE: The main aim was to investigate the associations between Magnetic Resonance Imaging (MRI)-defined structural pathologies of the knee and physical function. DESIGN: A cohort study with frequency matching on age and sex with eighty symptomatic subjects with knee pain and suspicion or diagnosis of knee osteoarthritis (OA) and 57 asymptomatic subjects was conducted. The subjects underwent knee MRI, and the severity of structural changes was graded by MRI Osteoarthritis Knee Score (MOAKS) in separate knee locations...
July 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28697785/effect-of-aquatic-physical-therapy-on-pain-perception-functional-capacity-and-quality-of-life-in-older-people-with-knee-osteoarthritis-study-protocol-for-a-randomized-controlled-trial
#18
Guilherme Eleutério Alcalde, Ana Carolina Fonseca, Thais Fernanda Bôscoa, Mirella Regina Gonçalves, Gabriele Candido Bernardo, Bruna Pianna, Bianca Ferdin Carnavale, Camila Gimenes, Silvia Regina Barrile, Eduardo Aguilar Arca
BACKGROUND: Aquatic therapy promotes short-term benefits for patients with knee osteoarthritis (OA), and it may be the first therapeutic option for this pathological condition. The objective of this study was to investigate the effects of an aquatic therapy program on pain intensity, functional ability, and quality of life in older people with knee OA. METHODS/DESIGN: This is a parallel, two-arm, open, randomized controlled clinical trial with older people with knee OA...
July 11, 2017: Trials
https://www.readbyqxmd.com/read/28695973/what-is-the-impact-of-body-mass-index-on-cardiovascular-and-musculoskeletal-health
#19
Morad Chughtai, Anton Khlopas, Jared M Newman, Gannon L Curtis, Nipun Sodhi, Prem N Ramkumar, Rafay Khan, Shervin Shaffiy, Ali Nadhim, Anil Bhave, Michael A Mont
Obesity has become a major public health concern over the past several decades and has been shown to be associated with type 2 diabetes, cardiovascular diseases, dyslipidemia, hypertension, osteoarthritis (OA), and certain types of cancer. The impact of excess weight on cardiovascular and musculoskeletal health is not well-summarized in the literature, and there are some contradictory reports. Therefore, the purpose of this study was to assess the impact of body mass index (BMI) on: 1) cardiovascular outcomes; 2) osteoarthritis risk and progression; and 3) total knee arthroplasty outcomes (TKA)...
July 11, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28695875/can-bariatric-surgery-delay-the-need-for-knee-replacement-in-morbidly-obese-osteoarthritis-patients
#20
Lajja Rishi, Mohit Bhandari, Ravindra Kumar
OBJECTIVE: The objective of the study was to find the weight reduction pattern and its outcome on knee pain and function in osteoarthritis (OA) morbidly obese patients' post-bariatric surgery with dietary and exercise changes. METHODOLOGY: Thirty morbidly obese (body mass index [BMI] >40 kg/m2) OA patients gave consent for bariatric surgery. Despite wearisome lifestyle modifications for weight loss and knee pain, satisfactory results were not retrieved. We took consent from all the patients predetermined for knee replacement in future because of pain and disability as recommended by knee replacement surgeon...
July 7, 2017: Journal of Minimal Access Surgery
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