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https://www.readbyqxmd.com/read/28924187/the-ipsych2012-case-cohort-sample-new-directions-for-unravelling-genetic-and-environmental-architectures-of-severe-mental-disorders
#1
C B Pedersen, J Bybjerg-Grauholm, M G Pedersen, J Grove, E Agerbo, M Bækvad-Hansen, J B Poulsen, C S Hansen, J J McGrath, T D Als, J I Goldstein, B M Neale, M J Daly, D M Hougaard, O Mors, M Nordentoft, A D Børglum, T Werge, P B Mortensen
The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. The iPSYCH2012 sample is nested within the entire Danish population born between 1981 and 2005, including 1 472 762 persons. This paper introduces the iPSYCH2012 sample and outlines key future research directions. Cases were identified as persons with schizophrenia (N=3540), autism (N=16 146), attention-deficit/hyperactivity disorder (N=18 726) and affective disorder (N=26 380), of which 1928 had bipolar affective disorder...
September 19, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28888362/risk-factors-for-increased-duration-of-untreated-psychosis-results-from-the-face-sz-dataset
#2
G Fond, L Boyer, M Andrianarisoa, O Godin, L Brunel, E Bulzacka, N Coulon, P M Llorca, F Berna, B Aouizerate, D Capdevielle, T D'Amato, C Dubertret, J Dubreucq, C Faget, F Gabayet, J Mallet, D Misdrahi, R Rey, R Richieri, P Roux, C Passerieux, A Schandrin, A M Tronche, P Vidailhet, M Leboyer, F Schürhoff
OBJECTIVES: Reducing the duration of untreated psychosis (DUP) may improve the prognosis of schizophrenia. This study investigated the prevalence, and associated risk factors, of long DUP in a large, non-selected sample of community-dwelling schizophrenia patients (SZ). METHOD: 478 community-dwelling stable SZ participants (122 women and 356 men; mean age 32.37±9.86years) were recruited between 2010 and 2016. The mean retrospective DUP was evaluated from both patient and family reports, as well as hospital/psychiatrists records...
September 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28843850/substance-use-disorders-in-adolescent-and-young-adult-relatives-of-probands-with-bipolar-disorder-what-drives-the-increased-risk
#3
Leslie A Hulvershorn, Jennifer King, Patrick O Monahan, Holly C Wilcox, Philip B Mitchell, Janice M Fullerton, Howard J Edenberg, Gloria M P Roberts, Masoud Kamali, Anne L Glowinski, Neera Ghaziuddin, Melvin McInnis, Priya A Iyer-Eimerbrink, John I Nurnberger
BACKGROUND: Adults with bipolar disorder (BD) have higher rates of substance use disorders (SUDs) compared to the general population. SUD rates in young offspring/relatives of BD probands, as well as factors which drive those rates, are not as well-characterized. METHODS: We aimed to examine SUD prevalence among adolescent/young adult offspring and relatives of probands with and without BD. Data were collected from five sites in the US and Australia during 2006-2011...
July 27, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28809398/precision-medicine-for-suicidality-from-universality-to-subtypes-and-personalization
#4
A B Niculescu, H Le-Niculescu, D F Levey, P L Phalen, H L Dainton, K Roseberry, E M Niculescu, J O Niezer, A Williams, D L Graham, T J Jones, V Venugopal, A Ballew, M Yard, T Gelbart, S M Kurian, A Shekhar, N J Schork, G E Sandusky, D R Salomon
Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders. Objective and precise identification of individuals at risk, ways of monitoring response to treatments and novel preventive therapeutics need to be discovered, employed and widely deployed. We sought to investigate whether blood gene expression biomarkers for suicide (that is, a 'liquid biopsy' approach) can be identified that are more universal in nature, working across psychiatric diagnoses and genders, using larger cohorts than in previous studies...
September 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28742074/untargeted-screening-for-novel-autoantibodies-with-prognostic-value-in-first-episode-psychosis
#5
A Zandian, L Wingård, H Nilsson, E Sjöstedt, D X Johansson, D Just, C Hellström, M Uhlén, J M Schwenk, A Häggmark-Månberg, O Norbeck, B Owe-Larsson, P Nilsson, M A A Persson
Immunological and inflammatory reactions have been suggested to have a role in the development of schizophrenia, a hypothesis that has recently been supported by genetic data. The aim of our study was to perform an unbiased search for autoantibodies in patients with a first psychotic episode, and to explore the association between any seroreactivity and the development of a Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) disorder characterized by chronic or relapsing psychotic symptoms...
July 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28722128/solar-insolation-in-springtime-influences-age-of-onset-of-bipolar-i-disorder
#6
M Bauer, T Glenn, M Alda, M A Aleksandrovich, O A Andreassen, E Angelopoulos, R Ardau, Y Ayhan, C Baethge, S R Bharathram, R Bauer, B T Baune, C Becerra-Palars, F Bellivier, R H Belmaker, M Berk, Y Bersudsky, Ş Bicakci, H Birabwa-Oketcho, T D Bjella, L Bossini, J Cabrera, E Y W Cheung, M Del Zompo, S Dodd, M Donix, B Etain, A Fagiolini, K N Fountoulakis, M A Frye, A Gonzalez-Pinto, J F Gottlieb, P Grof, H Harima, C Henry, E T Isometsä, S Janno, F Kapczinski, M Kardell, S Khaldi, S Kliwicki, B König, T L Kot, R Krogh, M Kunz, B Lafer, M Landén, E R Larsen, U Lewitzka, R W Licht, C Lopez-Jaramillo, G MacQueen, M Manchia, W Marsh, M Martinez-Cengotitabengoa, I Melle, F Meza-Urzúa, M Yee Ming, S Monteith, G Morken, E Mosca, R Munoz, S V Mythri, F Nacef, R K Nadella, F G Nery, R E Nielsen, C O'Donovan, A Omrani, Y Osher, H Østermark Sørensen, U Ouali, Y Pica Ruiz, M Pilhatsch, M Pinna, F D R da Ponte, D Quiroz, R Ramesar, N Rasgon, M S Reddy, A Reif, P Ritter, J K Rybakowski, K Sagduyu, Â M Scippa, E Severus, C Simhandl, D J Stein, S Strejilevich, M Subramaniam, A H Sulaiman, K Suominen, H Tagata, Y Tatebayashi, L Tondo, C Torrent, A E Vaaler, J Veeh, E Vieta, B Viswanath, M Yoldi-Negrete, M Zetin, Y Zgueb, P C Whybrow
OBJECTIVE: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. METHOD: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. RESULTS: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset...
July 19, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28706851/a-joint-time-frequency-analysis-of-resting-state-functional-connectivity-reveals-novel-patterns-of-connectivity-shared-between-or-unique-to-schizophrenia-patients-and-healthy-controls
#7
Maziar Yaesoubi, Robyn L Miller, Juan Bustillo, Kelvin O Lim, Jatin Vaidya, Vince D Calhoun
Functional connectivity of the resting-state (RS) brain is a vehicle to study brain dysconnectivity aspects of diseases such as schizophrenia and bipolar. Methods that are developed to measure functional connectivity are based on the underlying hypotheses regarding the actual nature of RS-connectivity including evidence of temporally dynamic versus static RS-connectivity and evidence of frequency-specific versus hemodynamically-driven connectivity over a wide frequency range. This study is derived by these observations of variation of RS-connectivity in temporal and frequency domains and evaluates such characteristics of RS-connectivity in clinical population and jointly in temporal and frequency domains (the spectro-temporal domain)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28632202/genome-wide-association-study-of-borderline-personality-disorder-reveals-genetic-overlap-with-bipolar-disorder-major-depression-and-schizophrenia
#8
S H Witt, F Streit, M Jungkunz, J Frank, S Awasthi, C S Reinbold, J Treutlein, F Degenhardt, A J Forstner, S Heilmann-Heimbach, L Dietl, C E Schwarze, D Schendel, J Strohmaier, A Abdellaoui, R Adolfsson, T M Air, H Akil, M Alda, N Alliey-Rodriguez, O A Andreassen, G Babadjanova, N J Bass, M Bauer, B T Baune, F Bellivier, S Bergen, A Bethell, J M Biernacka, D H R Blackwood, M P Boks, D I Boomsma, A D Børglum, M Borrmann-Hassenbach, P Brennan, M Budde, H N Buttenschøn, E M Byrne, P Cervantes, T-K Clarke, N Craddock, C Cruceanu, D Curtis, P M Czerski, U Dannlowski, T Davis, E J C de Geus, A Di Florio, S Djurovic, E Domenici, H J Edenberg, B Etain, S B Fischer, L Forty, C Fraser, M A Frye, J M Fullerton, K Gade, E S Gershon, I Giegling, S D Gordon, K Gordon-Smith, H J Grabe, E K Green, T A Greenwood, M Grigoroiu-Serbanescu, J Guzman-Parra, L S Hall, M Hamshere, J Hauser, M Hautzinger, U Heilbronner, S Herms, S Hitturlingappa, P Hoffmann, P Holmans, J-J Hottenga, S Jamain, I Jones, L A Jones, A Juréus, R S Kahn, J Kammerer-Ciernioch, G Kirov, S Kittel-Schneider, S Kloiber, S V Knott, M Kogevinas, M Landén, M Leber, M Leboyer, Q S Li, J Lissowska, S Lucae, N G Martin, F Mayoral-Cleries, S L McElroy, A M McIntosh, J D McKay, A McQuillin, S E Medland, C M Middeldorp, Y Milaneschi, P B Mitchell, G W Montgomery, G Morken, O Mors, T W Mühleisen, B Müller-Myhsok, R M Myers, C M Nievergelt, J I Nurnberger, M C O'Donovan, L M O Loohuis, R Ophoff, L Oruc, M J Owen, S A Paciga, B W J H Penninx, A Perry, A Pfennig, J B Potash, M Preisig, A Reif, F Rivas, G A Rouleau, P R Schofield, T G Schulze, M Schwarz, L Scott, G C B Sinnamon, E A Stahl, J Strauss, G Turecki, S Van der Auwera, H Vedder, J B Vincent, G Willemsen, C C Witt, N R Wray, H S Xi, A Tadic, N Dahmen, B H Schott, S Cichon, M M Nöthen, S Ripke, A Mobascher, D Rujescu, K Lieb, S Roepke, C Schmahl, M Bohus, M Rietschel
Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case-control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP...
June 20, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28599348/a-pilot-open-label-8-week-study-evaluating-the-efficacy-safety-and-tolerability-of-adjunctive-minocycline-for-the-treatment-of-bipolar-i-ii-depression
#9
Joanna K Soczynska, Sidney H Kennedy, Mohammad Alsuwaidan, Rodrigo B Mansur, Madeline Li, Mary Pat McAndrews, Elisa Brietzke, Hanna O Woldeyohannes, Valerie H Taylor, Roger S McIntyre
OBJECTIVES: The objectives of the study were to determine if adjunctive minocycline mitigates depressive symptom severity and improves cognitive function in individuals with bipolar I/II disorder (BD). The study also aimed to determine if changes in depressive and/or cognitive symptoms over the course of treatment were associated with changes in circulating inflammatory cytokine levels. METHODS: A total of 29 (intention-to-treat: n=27) adults meeting DSM-IV-TR criteria for a major depressive episode as part of bipolar I or II disorder (i...
May 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28577848/does-surgical-ablation-energy-source-affect-long-term-success-of-the-concomitant-cox-maze-procedure
#10
Niv Ad, Sari D Holmes, Anthony J Rongione, Paul S Massimiano, Lisa M Fornaresio
BACKGROUND: The Cox maze (CM) procedure is routinely performed using surgical ablation technology. Reports are scarce on long-term outcomes of CM, especially for a large series of patients. This study examined the potential impact of surgical ablation energy source on safety and long-term efficacy of concomitant CM procedures. METHODS: The study sample consisted of 709 concomitant CM-treated patients operated on with cryothermal energy only (group 1; n = 386) or combination of cryothermal and bipolar radiofrequency (group 2; n = 323)...
July 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28561179/-lithium-treatment-in-patients-with-impaired-kidney-function-between-scylla-and-charybdis
#11
Julia Dehning, Heinz Grunze, Christoph Born, Armand Hausmann
Introduction In quite a few patients with bipolar disorder there is no real alternative to lithium treatment despite impaired kidney function. Is it possible to continue lithium treatment despite kidney malfunction by changing dosage and/or frequency of administration? Case Report We report on a 65-year-old woman suffering from bipolar-I disorder who had been on lithium treatment for many decades. While on lithium, the glomerular filtration rate (GFR) decreased constantly. A decision had to be made whether to switch to a more tolerable o...
May 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28546489/genome-sequence-of-a-marine-spirillum-oceanospirillum-multiglobuliferum-atcc-33336-t-isolated-from-japan
#12
Joshua G Carney, Ariel M Trachtenberg, Bruce A Rheaume, Joshua D Linnane, Natalie L Pitts, Donald L Mykles, Kyle S MacLea
Oceanospirillum multiglobuliferum ATCC 33336(T) is a motile gammaproteobacterium with bipolar tufted flagella, noted for its low salt tolerance compared to other marine spirilla. This strain was originally isolated from the putrid infusions of Crassostrea gigas near Hiroshima, Japan. This paper presents a draft genome sequence for O. multiglobuliferum ATCC 33336(T).
May 25, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28546488/draft-genome-sequence-of-the-salt-water-bacterium-oceanospirillum-linum-atcc-11336-t
#13
Ariel M Trachtenberg, Joshua G Carney, Joshua D Linnane, Bruce A Rheaume, Natalie L Pitts, Donald L Mykles, Kyle S MacLea
Oceanospirillum linum ATCC 11336(T) is an aerobic, bipolar-tufted gammaproteobacterium first isolated in the Long Island Sound in the 1950s. This announcement offers a genome sequence for O. linum ATCC 11336(T), which has a predicted genome size of 3,782,189 bp (49.13% G+C content) containing 3,540 genes and 3,361 coding sequences.
May 25, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28542454/controlled-delivery-of-tauroursodeoxycholic-acid-from-biodegradable-microspheres-slows-retinal-degeneration-and-vision-loss-in-p23h-rats
#14
Laura Fernández-Sánchez, Irene Bravo-Osuna, Pedro Lax, Alicia Arranz-Romera, Victoria Maneu, Sergio Esteban-Pérez, Isabel Pinilla, María Del Mar Puebla-González, Rocío Herrero-Vanrell, Nicolás Cuenca
Successful drug therapies for treating ocular diseases require effective concentrations of neuroprotective compounds maintained over time at the site of action. The purpose of this work was to assess the efficacy of intravitreal controlled delivery of tauroursodeoxycholic acid (TUDCA) encapsulated in poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres for the treatment of the retina in a rat model of retinitis pigmentosa. PLGA microspheres (MSs) containing TUDCA were produced by the O/W emulsion-solvent evaporation technique...
2017: PloS One
https://www.readbyqxmd.com/read/28525775/the-association-between-systemic-lupus-erythematosus-and-bipolar-disorder%C3%A2-%C3%A2-a-big-data-analysis
#15
S Tiosano, Z Nir, O Gendelman, D Comaneshter, H Amital, A D Cohen, D Amital
BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease that has a wide variety of physical manifestations, including neuropsychiatric features. Bipolar disorder (BD) is a chronic, episodic illness, that may present as depression or as mania. The objective of this study was to investigate the association between SLE and BD using big data analysis methods. METHODS: Patients with SLE were compared with age- and sex-matched controls regarding the prevalence of BD in a cross-sectional study...
June 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28485725/sensory-integration-deficits-support-a-dimensional-view-of-psychosis-and-are-not-limited-to-schizophrenia
#16
O Carter, D Bennett, T Nash, S Arnold, L Brown, R Y Cai, Z Allan, A Dluzniak, K McAnally, D Burr, S Sundram
Visual dysfunction is commonplace in schizophrenia and occurs alongside cognitive, psychotic and affective symptoms of the disorder. Psychophysical evidence suggests that this dysfunction results from impairments in the integration of low-level neural signals into complex cortical representations, which may also be associated with symptom formation. Despite the symptoms of schizophrenia occurring in a range of disorders, the integration deficit has not been tested in broader patient populations. Moreover, it remains unclear whether such deficits generalize across other sensory modalities...
May 9, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28461699/cortical-abnormalities-in-bipolar-disorder-an-mri-analysis-of-6503-individuals-from-the-enigma-bipolar-disorder-working-group
#17
D P Hibar, L T Westlye, N T Doan, N Jahanshad, J W Cheung, C R K Ching, A Versace, A C Bilderbeck, A Uhlmann, B Mwangi, B Krämer, B Overs, C B Hartberg, C Abé, D Dima, D Grotegerd, E Sprooten, E Bøen, E Jimenez, F M Howells, G Delvecchio, H Temmingh, J Starke, J R C Almeida, J M Goikolea, J Houenou, L M Beard, L Rauer, L Abramovic, M Bonnin, M F Ponteduro, M Keil, M M Rive, N Yao, N Yalin, P Najt, P G Rosa, R Redlich, S Trost, S Hagenaars, S C Fears, S Alonso-Lana, T G M van Erp, T Nickson, T M Chaim-Avancini, T B Meier, T Elvsåshagen, U K Haukvik, W H Lee, A H Schene, A J Lloyd, A H Young, A Nugent, A M Dale, A Pfennig, A M McIntosh, B Lafer, B T Baune, C J Ekman, C A Zarate, C E Bearden, C Henry, C Simhandl, C McDonald, C Bourne, D J Stein, D H Wolf, D M Cannon, D C Glahn, D J Veltman, E Pomarol-Clotet, E Vieta, E J Canales-Rodriguez, F G Nery, F L S Duran, G F Busatto, G Roberts, G D Pearlson, G M Goodwin, H Kugel, H C Whalley, H G Ruhe, J C Soares, J M Fullerton, J K Rybakowski, J Savitz, K T Chaim, M Fatjó-Vilas, M G Soeiro-de-Souza, M P Boks, M V Zanetti, M C G Otaduy, M S Schaufelberger, M Alda, M Ingvar, M L Phillips, M J Kempton, M Bauer, M Landén, N S Lawrence, N E M van Haren, N R Horn, N B Freimer, O Gruber, P R Schofield, P B Mitchell, R S Kahn, R Lenroot, R Machado-Vieira, R A Ophoff, S Sarró, S Frangou, T D Satterthwaite, T Hajek, U Dannlowski, U F Malt, V Arolt, W F Gattaz, W C Drevets, X Caseras, I Agartz, P M Thompson, O A Andreassen
Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies have been inconsistent. To address this, we performed the largest study to date of cortical gray matter thickness and surface area measures from brain magnetic resonance imaging scans of 6503 individuals including 1837 unrelated adults with BD and 2582 unrelated healthy controls for group differences while also examining the effects of commonly prescribed medications, age of illness onset, history of psychosis, mood state, age and sex differences on cortical regions...
May 2, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28439101/largest-gwas-of-ptsd-n-20%C3%A2-070-yields-genetic-overlap-with-schizophrenia-and-sex-differences-in-heritability
#18
L E Duncan, A Ratanatharathorn, A E Aiello, L M Almli, A B Amstadter, A E Ashley-Koch, D G Baker, J C Beckham, L J Bierut, J Bisson, B Bradley, C-Y Chen, S Dalvie, L A Farrer, S Galea, M E Garrett, J E Gelernter, G Guffanti, M A Hauser, E O Johnson, R C Kessler, N A Kimbrel, A King, N Koen, H R Kranzler, M W Logue, A X Maihofer, A R Martin, M W Miller, R A Morey, N R Nugent, J P Rice, S Ripke, A L Roberts, N L Saccone, J W Smoller, D J Stein, M B Stein, J A Sumner, M Uddin, R J Ursano, D E Wildman, R Yehuda, H Zhao, M J Daly, I Liberzon, K J Ressler, C M Nievergelt, K C Koenen
The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-PTSD) combined genome-wide case-control molecular genetic data across 11 multiethnic studies to quantify PTSD heritability, to examine potential shared genetic risk with schizophrenia, bipolar disorder, and major depressive disorder and to identify risk loci for PTSD. Examining 20 730 individuals, we report a molecular genetics-based heritability estimate (h(2)SNP) for European-American females of 29% that is similar to h(2)SNP for schizophrenia and is substantially higher than h(2)SNP in European-American males (estimate not distinguishable from zero)...
April 25, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28363877/subacromial-temperature-profile-during-bipolar-radiofrequency-use-in-shoulder-arthroscopy-comparison-of-coblation-%C3%A2-vs-vapr-%C3%A2
#19
V Huynh, O Barbier, X Bajard, A Bouchard, D Ollat, G Versier
BACKGROUND: The use of bipolar electrodes for arthroscopic procedures carries a theoretical ex vivo risk of inducing burn injuries. Few studies have measured the in vivo temperatures produced by bipolar electrodes during arthroscopy, and their results are conflicting. The objective of this study was to evaluate the temperature profile within the subacromial space during shoulder arthroscopy with two different electrode systems. HYPOTHESIS: The primary hypothesis was that the two electrode systems produced similar temperature variations and peak temperatures...
June 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28289283/the-dopamine-hypothesis-of-bipolar-affective-disorder-the-state-of-the-art-and-implications-for-treatment
#20
REVIEW
A H Ashok, T R Marques, S Jauhar, M M Nour, G M Goodwin, A H Young, O D Howes
Bipolar affective disorder is a common neuropsychiatric disorder. Although its neurobiological underpinnings are incompletely understood, the dopamine hypothesis has been a key theory of the pathophysiology of both manic and depressive phases of the illness for over four decades. The increased use of antidopaminergics in the treatment of this disorder and new in vivo neuroimaging and post-mortem studies makes it timely to review this theory. To do this, we conducted a systematic search for post-mortem, pharmacological, functional magnetic resonance and molecular imaging studies of dopamine function in bipolar disorder...
May 2017: Molecular Psychiatry
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