keyword
MENU ▼
Read by QxMD icon Read
search

Bipolar D/O

keyword
https://www.readbyqxmd.com/read/27894373/cognitive-effects-of-adjunctive-n-acetyl-cysteine-in-psychosis
#1
M Rapado-Castro, S Dodd, A I Bush, G S Malhi, D R Skvarc, Z X On, M Berk, O M Dean
BACKGROUND: Cognitive deficits are predictors of functional outcome in patients with psychosis. While conventional antipsychotics are relatively effective on positive symptoms, their impact on negative and cognitive symptoms is limited. Recent studies have established a link between oxidative stress and neurocognitive deficits in psychosis. N-acetylcysteine (NAC), a glutathione precursor with glutamatergic properties, has shown efficacy on negative symptoms and functioning in patients with schizophrenia and bipolar disorder, respectively...
November 29, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27845315/-agomelatine-valdoxan-in-treatment-of-endogenous-depression-in-day-patient-department
#2
E V Chernova, O V Kozhechkina, A Yu Ter-Israelyan, V E Medvedev
AIM: Naturalistic psychopharmacological study of efficacy and tolerability of agomelatine (valdoxan) in treatment of endogenous depressions (in the framework of schizophrenia, schizoaffective and bipolar disorder) in day patient department. MATERIAL AND METHODS: Study sample consisted of 37 patient (59.4% female, mean age 41.6±3.7 years). RESULTS AND CONCLUSION: CDS total score significantly reduced after 8 weeks of treatment 44.9% compared to baseline (р<0...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27834153/childhood-trauma-is-associated-with-increased-brain-responses-to-emotionally-negative-as-compared-with-positive-faces-in-patients-with-psychotic-disorders
#3
M Aas, K Kauppi, C L Brandt, M Tesli, T Kaufmann, N E Steen, I Agartz, L T Westlye, O A Andreassen, I Melle
BACKGROUND: Childhood trauma increases risk of a range of mental disorders including psychosis. Whereas the mechanisms are unclear, previous evidence has implicated atypical processing of emotions among the core cognitive models, in particular suggesting altered attentional allocation towards negative stimuli and increased negativity bias. Here, we tested the association between childhood trauma and brain activation during emotional face processing in patients diagnosed with psychosis continuum disorders...
November 11, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27830632/alcohol-use-is-associated-with-thinner-cerebral-cortex-and-larger-ventricles-in-schizophrenia-bipolar-disorder-and-healthy-controls
#4
E H Lange, S Nerland, K N Jørgensen, L Mørch-Johnsen, R Nesvåg, C B Hartberg, U K Haukvik, K Osnes, I Melle, O A Andreassen, I Agartz
BACKGROUND: Excessive alcohol use is associated with brain damage but less is known about brain effects from moderate alcohol use. Previous findings indicate that patients with severe mental illness, particularly schizophrenia, are vulnerable to alcohol-related brain damage. We investigated the association between levels of alcohol consumption and cortical and subcortical brain structures in schizophrenia and bipolar disorder patients and healthy controls, and investigated for group differences for this association...
November 10, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27772831/bipolar-radiofrequency-ablation-for-thyroid-nodules-with-effective-induction-of-sufficiently-large-lesions-without-danger-to-surrounding-structures-ex-vivo-morphological-evaluation
#5
D I Branovan, M Fridman, O Krasko, M Lushchik, V Drozd, N Shiglik, L Danilova, Y Demidchik
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27721184/liraglutide-promotes-improvements-in-objective-measures-of-cognitive-dysfunction-in-individuals-with-mood-disorders-a-pilot-open-label-study
#6
Rodrigo B Mansur, Juhie Ahmed, Danielle S Cha, Hanna O Woldeyohannes, Mehala Subramaniapillai, Julie Lovshin, Jung G Lee, Jae-Hon Lee, Elisa Brietzke, Eva Z Reininghaus, Kang Sim, Maj Vinberg, Natalie Rasgon, Tomas Hajek, Roger S McIntyre
BACKGROUND: There is a paucity of treatments that are capable of reliably and robustly improving cognitive function in adults with mood disorders. Glucagon-like peptide-1 is synthesized centrally and its receptors are abundantly expressed in neural circuits subserving cognitive function. We aimed to determine the effects of liraglutide, a GLP-1 receptor (GLP-1R) agonist, on objective measures of cognition in adults with a depressive or bipolar disorder. METHODS: In this 4-week, pilot, open-label, domain-based study (e...
January 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27622935/evidence-that-comt-genotype-and-proline-interact-on-negative-symptom-outcomes-in-schizophrenia-and-bipolar-disorder
#7
C L Clelland, V Drouet, K C Rilett, J A Smeed, R H Nadrich, A Rajparia, L L Read, J D Clelland
Elevated peripheral proline is associated with psychiatric disorders, and there is evidence that proline is a neuromodulator. The proline dehydrogenase (PRODH) gene, which encodes the enzyme that catalyzes proline catabolism, maps to human chromosome 22q11.2, a region conferring risk of schizophrenia. In the Prodh-null mouse, an interaction between elevated peripheral proline and another 22q11.2 gene, catechol-O-methyltransferase (COMT), on neurotransmission and behavior has been reported. We explored the relationship between fasting plasma proline levels and COMT Val(158)Met genotype on symptoms (positive, negative and total) in schizophrenia patients...
September 13, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27576186/brain-hyper-excitability-revealed-by-optimal-electrical-stimulation-of-gabaergic-interneurons
#8
F Wendling, U Gerber, D Cosandier-Rimele, A Nica, J De Montigny, O Raineteau, S Kalitzin, F Lopes da Silva, P Benquet
BACKGROUND: Neurological disorders are often characterized by an excessive and prolonged imbalance between neural excitatory and inhibitory processes. An ubiquitous finding among these disorders is the disrupted function of inhibitory GABAergic interneurons. OBJECTIVE: The objective is to propose a novel stimulation procedure able to evaluate the efficacy of inhibition imposed by GABAergic interneurons onto pyramidal cells from evoked responses observed in local field potentials (LFPs)...
November 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27524481/mismatch-of-synaptic-patterns-between-neurons-produced-in-regeneration-and-during-development-of-the-vertebrate-retina
#9
Florence D D'Orazi, Xiao-Feng Zhao, Rachel O Wong, Takeshi Yoshimatsu
Stereotypic patterns of synaptic connections between neurons underlie the ability of the CNS to perform complex but circuit-specific information processing. Tremendous progress has been made toward advancing our understanding of how circuits are assembled during development, but whether the precision of this process can be recaptured after regeneration of neurons in the damaged CNS remains unclear. Here, we harnessed the endogenous regenerative capacity of the zebrafish retina to reconstruct the circuitry of neurons produced after damage...
September 12, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27457814/sorcs2-is-required-for-bdnf-dependent-plasticity-in-the-hippocampus
#10
S Glerup, U Bolcho, S Mølgaard, S Bøggild, C B Vaegter, A H Smith, J L Nieto-Gonzalez, P L Ovesen, L F Pedersen, A N Fjorback, M Kjolby, H Login, M M Holm, O M Andersen, J R Nyengaard, T E Willnow, K Jensen, A Nykjaer
SorCS2 is a member of the Vps10p-domain receptor gene family receptors with critical roles in the control of neuronal viability and function. Several genetic studies have suggested SORCS2 to confer risk of bipolar disorder, schizophrenia and attention deficit-hyperactivity disorder. Here we report that hippocampal N-methyl-d-aspartate receptor-dependent synaptic plasticity is eliminated in SorCS2-deficient mice. This defect was traced to the ability of SorCS2 to form complexes with the neurotrophin receptor p75(NTR), required for pro-brain-derived neurotrophic factor (BDNF) to induce long-term depression, and with the BDNF receptor tyrosine kinase TrkB to elicit long-term potentiation...
December 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27416076/single-residue-aav-capsid-mutation-improves-transduction-of-photoreceptors-in-the-abca4-mouse-and-bipolar-cells-in-the-rd1-mouse-and-human-retina-ex-vivo
#11
S R De Silva, P Charbel Issa, M S Singh, D M Lipinski, A O Barnea-Cramer, N J Walker, A R Barnard, M W Hankins, R E MacLaren
Gene therapy using adeno-associated viral (AAV) vectors for the treatment of retinal degenerations has shown safety and efficacy in clinical trials. However, very high levels of vector expression may be necessary for the treatment of conditions such as Stargardt disease where a dual vector approach is potentially needed, or in optogenetic strategies for end-stage degeneration in order to achieve maximal light sensitivity. In this study, we assessed two vectors with single capsid mutations, rAAV2/2(Y444F) and rAAV2/8(Y733F) in their ability to transduce retina in the Abca4(-/-) and rd1 mouse models of retinal degeneration...
November 2016: Gene Therapy
https://www.readbyqxmd.com/read/27349652/birth-by-cesarean-section-and-schizophrenia-results-from-the-multicenter-face-sz-data-set
#12
G Fond, E Bulzacka, L Boyer, P M Llorca, O Godin, L Brunel, M G Andrianarisoa, B Aouizerate, F Berna, D Capdevielle, I Chereau, H Denizot, J M Dorey, C Dubertret, J Dubreucq, C Faget, F Gabayet, Y Le Strat, J A Micoulaud-Franchi, D Misdrahi, R Rey, R Richieri, M Roger, C Passerieux, A Schandrin, M Urbach, P Vidalhet, F Schürhoff, M Leboyer
Children born by cesarean section ("c-birth") are known to have different microbiota and a natural history of different disorders including allergy, asthma and overweight compared to vaginally born ("v-birth") children. C-birth is not known to increase the risk of schizophrenia (SZ), but to be associated with an earlier age at onset. To further explore possible links between c-birth and SZ, we compared clinical and biological characteristics of c-born SZ patients compared to v-born ones. Four hundred and fifty-four stable community-dwelling SZ patients (mean age = 32...
June 27, 2016: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/27299091/simultaneous-bilateral-femur-neck-fracture-in-a-young-adult-with-chronic-renal-failure-a-case-report-and-review-of-literature
#13
Sathyanarayana V, Maulik Tulsibhai Patel, Raghavan S, Naresh D
INTRODUCTION: Pathological bilateral femoral neck fracture due to renal osteodystrophy is rare. This is a report of a chronic renal failure patient who had sustained bilateral intra-capsular displaced fracture neck of femur following an episode of convulsion and the difficulties encountered in early diagnosis and treatment. The pathophysiology of renal osteodystrophy and the treatment of hip fractures in patients with renal failure are also discussed. CASE REPORT: A 23 years old male patient admitted with h/o dysuria, pyuria and loss of appetite since 3 months...
October 2015: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/27291558/comparing-the-short-term-outcomes-and-complications-of-monopolar-and-bipolar-transurethral-resection-of-non-muscle-invasive-bladder-cancers-a-prospective-randomized-controlled-study
#14
RANDOMIZED CONTROLLED TRIAL
Deniz Bolat, Bulent Gunlusoy, Tansu Degirmenci, Yasin Ceylan, Salih Polat, Erhan Aydin, Ozgu Aydogdu, Zafer Kozacioglu
OBJECTIVES: To compare perioperative outcomes and complications of plasmakinetic bipolar and monopolar transurethral resection of bladder tumors (TURBT) in patients with non-muscle invasive bladder cancer (NMIBC). METHODS: Between March and December 2015, a total of 130 consecutive patients underwent TURBT for NMIBC. Patients were equally randomized into monopolar TURBT (M-TURBT) and bipolar TURBT (B-TURBT) groups. Primary outcome of this study was safety of the procedures including obturator jerk, bladder perforation, clot retention, febrile urinary tract infection and TUR syndrome...
June 2016: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/27271857/cacna1c-hypermethylation-is-associated-with-bipolar-disorder
#15
A Starnawska, D Demontis, A Pen, A Hedemand, A L Nielsen, N H Staunstrup, J Grove, T D Als, A Jarram, N L O'Brien, O Mors, A McQuillin, A D Børglum, M Nyegaard
The CACNA1C gene, encoding a subunit of the L-type voltage-gated calcium channel is one of the best-supported susceptibility genes for bipolar disorder (BD). Genome-wide association studies have identified a cluster of non-coding single-nucleotide polymorphisms (SNPs) in intron 3 to be highly associated with BD and schizophrenia. The mechanism by which these SNPs confer risk of BD appears to be through an altered regulation of CACNA1C expression. The role of CACNA1C DNA methylation in BD has not yet been addressed...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27255576/whole-exome-sequencing-implicates-dgkh-as-a-risk-gene-for-panic-disorder-in-the-faroese-population
#16
Noomi O Gregersen, Francesco Lescai, Jieqin Liang, Qibin Li, Thomas Als, Henriette N Buttenschøn, Anne Hedemand, Marjun Biskopstø, Jun Wang, August G Wang, Anders D Børglum, Ole Mors, Ditte Demontis
The demographic history of the isolated population of the Faroe Islands may have induced enrichment of variants rarely seen in outbred European populations, including enrichment of risk variants for panic disorder (PD). PD is a common mental disorder, characterized by recurring and unprovoked panic attacks, and genetic factors have been estimated to explain around 40% of the risk. In this study the potential enrichment of PD risk variants was explored based on whole-exome sequencing of 54 patients with PD and 211 control individuals from the Faroese population...
December 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/27217146/common-and-distinct-patterns-of-grey-matter-volume-alteration-in-major-depression-and-bipolar-disorder-evidence-from-voxel-based-meta-analysis
#17
T Wise, J Radua, E Via, N Cardoner, O Abe, T M Adams, F Amico, Y Cheng, J H Cole, C de Azevedo Marques Périco, D P Dickstein, T F D Farrow, T Frodl, G Wagner, I H Gotlib, O Gruber, B J Ham, D E Job, M J Kempton, M J Kim, P C M P Koolschijn, G S Malhi, D Mataix-Cols, A M McIntosh, A C Nugent, J T O'Brien, S Pezzoli, M L Phillips, P S Sachdev, G Salvadore, S Selvaraj, A C Stanfield, A J Thomas, M J van Tol, N J A van der Wee, D J Veltman, A H Young, C H Fu, A J Cleare, D Arnone
Finding robust brain substrates of mood disorders is an important target for research. The degree to which major depression (MDD) and bipolar disorder (BD) are associated with common and/or distinct patterns of volumetric changes is nevertheless unclear. Furthermore, the extant literature is heterogeneous with respect to the nature of these changes. We report a meta-analysis of voxel-based morphometry (VBM) studies in MDD and BD. We identified studies published up to January 2015 that compared grey matter in MDD (50 data sets including 4101 individuals) and BD (36 data sets including 2407 individuals) using whole-brain VBM...
May 24, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27143891/patterns-of-psychotropic-medication-use-in-inpatient-and-outpatient-psychiatric-settings-in-saudi-arabia
#18
Fahad D Alosaimi, Abdulhadi Alhabbad, Mohammed F Abalhassan, Ebtihaj O Fallata, Nasser M Alzain, Mohammad Zayed Alassiry, Bander Abdullah Haddad
OBJECTIVE: To study the pattern of psychotropic medication use and compare this pattern between inpatient and outpatient psychiatric settings in Saudi Arabia. METHOD: This cross-sectional observational study was conducted between July 2012 and June 2014 on patients seeking psychiatric advice at major hospitals in five main regions of Saudi Arabia. Male (n=651) and female (n=594) patients who signed the informed consent form and were currently or had been previously using psychotropic medications, irrespective of the patient's type of psychiatric diagnosis and duration of the disease, were included...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/26994004/sister-chromatid-separation-and-monopolar-spindle-organization-in-the-first-meiosis-as-two-mechanisms-of-unreduced-gametes-formation-in-wheat-rye-hybrids
#19
O G Silkova, D B Loginova
Unreduced gametes. The absence of a strict pachytene checkpoint in plants presents an opportunity to study meiosis in polyhaploid organisms. In the present study, we demonstrate that meiosis is coordinated in hybrids between disomic wheat-rye substitution lines 1Rv(1A), 2R(2D), 5R(5D), 6R(6A) and rye (Triticum aestivum L. × Secale cereale L., 4x = 28, ABDR). By using in situ hybridization with a centromere pAet6-09 probe and immunostaining with H3Ser10ph-, CENH3-, and α-tubulin-specific antibodies, we distinguished four chromosome behaviour types...
June 2016: Plant Reproduction
https://www.readbyqxmd.com/read/26979387/evidence-based-guidelines-for-treating-bipolar-disorder-revised-third-edition-recommendations-from-the-british-association-for-psychopharmacology
#20
G M Goodwin, P M Haddad, I N Ferrier, J K Aronson, Trh Barnes, A Cipriani, D R Coghill, S Fazel, J R Geddes, H Grunze, E A Holmes, O Howes, S Hudson, N Hunt, I Jones, I C Macmillan, H McAllister-Williams, D R Miklowitz, R Morriss, M Munafò, C Paton, B J Saharkian, Kea Saunders, Jma Sinclair, D Taylor, E Vieta, A H Young
The British Association for Psychopharmacology guidelines specify the scope and targets of treatment for bipolar disorder. The third version is based explicitly on the available evidence and presented, like previous Clinical Practice Guidelines, as recommendations to aid clinical decision making for practitioners: it may also serve as a source of information for patients and carers, and assist audit. The recommendations are presented together with a more detailed review of the corresponding evidence. A consensus meeting, involving experts in bipolar disorder and its treatment, reviewed key areas and considered the strength of evidence and clinical implications...
June 2016: Journal of Psychopharmacology
keyword
keyword
42929
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"