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Bipolar D/O

Rodrigo B Mansur, Juhie Ahmed, Danielle S Cha, Hanna O Woldeyohannes, Mehala Subramaniapillai, Julie Lovshin, Jung G Lee, Jae-Hon Lee, Elisa Brietzke, Eva Z Reininghaus, Kang Sim, Maj Vinberg, Natalie Rasgon, Tomas Hajek, Roger S McIntyre
BACKGROUND: There is a paucity of treatments that are capable of reliably and robustly improving cognitive function in adults with mood disorders. Glucagon-like peptide-1 is synthesized centrally and its receptors are abundantly expressed in neural circuits subserving cognitive function. We aimed to determine the effects of liraglutide, a GLP-1 receptor (GLP-1R) agonist, on objective measures of cognition in adults with a depressive or bipolar disorder. METHODS: In this 4-week, pilot, open-label, domain-based study (e...
October 1, 2016: Journal of Affective Disorders
C L Clelland, V Drouet, K C Rilett, J A Smeed, R H Nadrich, A Rajparia, L L Read, J D Clelland
Elevated peripheral proline is associated with psychiatric disorders, and there is evidence that proline is a neuromodulator. The proline dehydrogenase (PRODH) gene, which encodes the enzyme that catalyzes proline catabolism, maps to human chromosome 22q11.2, a region conferring risk of schizophrenia. In the Prodh-null mouse, an interaction between elevated peripheral proline and another 22q11.2 gene, catechol-O-methyltransferase (COMT), on neurotransmission and behavior has been reported. We explored the relationship between fasting plasma proline levels and COMT Val(158)Met genotype on symptoms (positive, negative and total) in schizophrenia patients...
2016: Translational Psychiatry
F Wendling, U Gerber, D Cosandier-Rimele, A Nica, J De Montigny, O Raineteau, S Kalitzin, F Lopes da Silva, P Benquet
BACKGROUND: Neurological disorders are often characterized by an excessive and prolonged imbalance between neural excitatory and inhibitory processes. An ubiquitous finding among these disorders is the disrupted function of inhibitory GABAergic interneurons. OBJECTIVE: The objective is to propose a novel stimulation procedure able to evaluate the efficacy of inhibition imposed by GABAergic interneurons onto pyramidal cells from evoked responses observed in local field potentials (LFPs)...
July 15, 2016: Brain Stimulation
Florence D D'Orazi, Xiao-Feng Zhao, Rachel O Wong, Takeshi Yoshimatsu
Stereotypic patterns of synaptic connections between neurons underlie the ability of the CNS to perform complex but circuit-specific information processing. Tremendous progress has been made toward advancing our understanding of how circuits are assembled during development, but whether the precision of this process can be recaptured after regeneration of neurons in the damaged CNS remains unclear. Here, we harnessed the endogenous regenerative capacity of the zebrafish retina to reconstruct the circuitry of neurons produced after damage...
September 12, 2016: Current Biology: CB
S Glerup, U Bolcho, S Mølgaard, S Bøggild, C B Vaegter, A H Smith, J L Nieto-Gonzalez, P L Ovesen, L F Pedersen, A N Fjorback, M Kjolby, H Login, M M Holm, O M Andersen, J R Nyengaard, T E Willnow, K Jensen, A Nykjaer
SorCS2 is a member of the Vps10p-domain receptor gene family receptors with critical roles in the control of neuronal viability and function. Several genetic studies have suggested SORCS2 to confer risk of bipolar disorder, schizophrenia and attention deficit-hyperactivity disorder. Here we report that hippocampal N-methyl-d-aspartate receptor-dependent synaptic plasticity is eliminated in SorCS2-deficient mice. This defect was traced to the ability of SorCS2 to form complexes with the neurotrophin receptor p75(NTR), required for pro-brain-derived neurotrophic factor (BDNF) to induce long-term depression, and with the BDNF receptor tyrosine kinase TrkB to elicit long-term potentiation...
July 26, 2016: Molecular Psychiatry
S R De Silva, P C Issa, M S Singh, D M Lipinski, A O Barnea-Cramer, N J Walker, A R Barnard, M W Hankins, R E MacLaren
Gene therapy using adeno-associated viral vectors (AAV) for the treatment of retinal degenerations has shown safety and efficacy in clinical trials. However, very high levels of vector expression may be necessary for the treatment of conditions such as Stargardt disease where a dual vector approach is potentially needed, or in optogenetic strategies for end-stage degeneration in order to achieve maximal light sensitivity. In this study, we assessed two vectors with single capsid mutations, rAAV2/2(Y444F) and rAAV2/8(Y733F) in their ability to transduce retina in the Abca4(-/-) and rd1 mouse models of retinal degeneration...
July 14, 2016: Gene Therapy
G Fond, E Bulzacka, L Boyer, P M Llorca, O Godin, L Brunel, M G Andrianarisoa, B Aouizerate, F Berna, D Capdevielle, I Chereau, H Denizot, J M Dorey, C Dubertret, J Dubreucq, C Faget, F Gabayet, Y Le Strat, J A Micoulaud-Franchi, D Misdrahi, R Rey, R Richieri, M Roger, C Passerieux, A Schandrin, M Urbach, P Vidalhet, F Schürhoff, M Leboyer
Children born by cesarean section ("c-birth") are known to have different microbiota and a natural history of different disorders including allergy, asthma and overweight compared to vaginally born ("v-birth") children. C-birth is not known to increase the risk of schizophrenia (SZ), but to be associated with an earlier age at onset. To further explore possible links between c-birth and SZ, we compared clinical and biological characteristics of c-born SZ patients compared to v-born ones. Four hundred and fifty-four stable community-dwelling SZ patients (mean age = 32...
June 27, 2016: European Archives of Psychiatry and Clinical Neuroscience
Sathyanarayana V, Maulik Tulsibhai Patel, Raghavan S, Naresh D
INTRODUCTION: Pathological bilateral femoral neck fracture due to renal osteodystrophy is rare. This is a report of a chronic renal failure patient who had sustained bilateral intra-capsular displaced fracture neck of femur following an episode of convulsion and the difficulties encountered in early diagnosis and treatment. The pathophysiology of renal osteodystrophy and the treatment of hip fractures in patients with renal failure are also discussed. CASE REPORT: A 23 years old male patient admitted with h/o dysuria, pyuria and loss of appetite since 3 months...
October 2015: Journal of Orthopaedic Case Reports
Deniz Bolat, Bulent Gunlusoy, Tansu Degirmenci, Yasin Ceylan, Salih Polat, Erhan Aydin, Ozgu Aydogdu, Zafer Kozacioglu
OBJECTIVES: To compare perioperative outcomes and complications of plasmakinetic bipolar and monopolar transurethral resection of bladder tumors (TURBT) in patients with non-muscle invasive bladder cancer (NMIBC). METHODS: Between March and December 2015, a total of 130 consecutive patients underwent TURBT for NMIBC. Patients were equally randomized into monopolar TURBT (M-TURBT) and bipolar TURBT (B-TURBT) groups. Primary outcome of this study was safety of the procedures including obturator jerk, bladder perforation, clot retention, febrile urinary tract infection and TUR syndrome...
June 2016: Archivos Españoles de Urología
A Starnawska, D Demontis, A Pen, A Hedemand, A L Nielsen, N H Staunstrup, J Grove, T D Als, A Jarram, N L O'Brien, O Mors, A McQuillin, A D Børglum, M Nyegaard
The CACNA1C gene, encoding a subunit of the L-type voltage-gated calcium channel is one of the best-supported susceptibility genes for bipolar disorder (BD). Genome-wide association studies have identified a cluster of non-coding single-nucleotide polymorphisms (SNPs) in intron 3 to be highly associated with BD and schizophrenia. The mechanism by which these SNPs confer risk of BD appears to be through an altered regulation of CACNA1C expression. The role of CACNA1C DNA methylation in BD has not yet been addressed...
2016: Translational Psychiatry
Noomi O Gregersen, Francesco Lescai, Jieqin Liang, Qibin Li, Thomas Als, Henriette N Buttenschøn, Anne Hedemand, Marjun Biskopstø, Jun Wang, August G Wang, Anders D Børglum, Ole Mors, Ditte Demontis
The demographic history of the isolated population of the Faroe Islands may have induced enrichment of variants rarely seen in outbred European populations, including enrichment of risk variants for panic disorder (PD). PD is a common mental disorder, characterized by recurring and unprovoked panic attacks, and genetic factors have been estimated to explain around 40% of the risk. In this study the potential enrichment of PD risk variants was explored based on whole-exome sequencing of 54 patients with PD and 211 control individuals from the Faroese population...
June 3, 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
T Wise, J Radua, E Via, N Cardoner, O Abe, T M Adams, F Amico, Y Cheng, J H Cole, C de Azevedo Marques Périco, D P Dickstein, T F D Farrow, T Frodl, G Wagner, I H Gotlib, O Gruber, B J Ham, D E Job, M J Kempton, M J Kim, P C M P Koolschijn, G S Malhi, D Mataix-Cols, A M McIntosh, A C Nugent, J T O'Brien, S Pezzoli, M L Phillips, P S Sachdev, G Salvadore, S Selvaraj, A C Stanfield, A J Thomas, M J van Tol, N J A van der Wee, D J Veltman, A H Young, C H Fu, A J Cleare, D Arnone
Finding robust brain substrates of mood disorders is an important target for research. The degree to which major depression (MDD) and bipolar disorder (BD) are associated with common and/or distinct patterns of volumetric changes is nevertheless unclear. Furthermore, the extant literature is heterogeneous with respect to the nature of these changes. We report a meta-analysis of voxel-based morphometry (VBM) studies in MDD and BD. We identified studies published up to January 2015 that compared grey matter in MDD (50 data sets including 4101 individuals) and BD (36 data sets including 2407 individuals) using whole-brain VBM...
May 24, 2016: Molecular Psychiatry
Fahad D Alosaimi, Abdulhadi Alhabbad, Mohammed F Abalhassan, Ebtihaj O Fallata, Nasser M Alzain, Mohammad Zayed Alassiry, Bander Abdullah Haddad
OBJECTIVE: To study the pattern of psychotropic medication use and compare this pattern between inpatient and outpatient psychiatric settings in Saudi Arabia. METHOD: This cross-sectional observational study was conducted between July 2012 and June 2014 on patients seeking psychiatric advice at major hospitals in five main regions of Saudi Arabia. Male (n=651) and female (n=594) patients who signed the informed consent form and were currently or had been previously using psychotropic medications, irrespective of the patient's type of psychiatric diagnosis and duration of the disease, were included...
2016: Neuropsychiatric Disease and Treatment
O G Silkova, D B Loginova
Unreduced gametes. The absence of a strict pachytene checkpoint in plants presents an opportunity to study meiosis in polyhaploid organisms. In the present study, we demonstrate that meiosis is coordinated in hybrids between disomic wheat-rye substitution lines 1Rv(1A), 2R(2D), 5R(5D), 6R(6A) and rye (Triticum aestivum L. × Secale cereale L., 4x = 28, ABDR). By using in situ hybridization with a centromere pAet6-09 probe and immunostaining with H3Ser10ph-, CENH3-, and α-tubulin-specific antibodies, we distinguished four chromosome behaviour types...
June 2016: Plant Reproduction
G M Goodwin, P M Haddad, I N Ferrier, J K Aronson, Trh Barnes, A Cipriani, D R Coghill, S Fazel, J R Geddes, H Grunze, E A Holmes, O Howes, S Hudson, N Hunt, I Jones, I C Macmillan, H McAllister-Williams, D R Miklowitz, R Morriss, M Munafò, C Paton, B J Saharkian, Kea Saunders, Jma Sinclair, D Taylor, E Vieta, A H Young
The British Association for Psychopharmacology guidelines specify the scope and targets of treatment for bipolar disorder. The third version is based explicitly on the available evidence and presented, like previous Clinical Practice Guidelines, as recommendations to aid clinical decision making for practitioners: it may also serve as a source of information for patients and carers, and assist audit. The recommendations are presented together with a more detailed review of the corresponding evidence. A consensus meeting, involving experts in bipolar disorder and its treatment, reviewed key areas and considered the strength of evidence and clinical implications...
June 2016: Journal of Psychopharmacology
D P Hibar, L T Westlye, T G M van Erp, J Rasmussen, C D Leonardo, J Faskowitz, U K Haukvik, C B Hartberg, N T Doan, I Agartz, A M Dale, O Gruber, B Krämer, S Trost, B Liberg, C Abé, C J Ekman, M Ingvar, M Landén, S C Fears, N B Freimer, C E Bearden, E Sprooten, D C Glahn, G D Pearlson, L Emsell, J Kenney, C Scanlon, C McDonald, D M Cannon, J Almeida, A Versace, X Caseras, N S Lawrence, M L Phillips, D Dima, G Delvecchio, S Frangou, T D Satterthwaite, D Wolf, J Houenou, C Henry, U F Malt, E Bøen, T Elvsåshagen, A H Young, A J Lloyd, G M Goodwin, C E Mackay, C Bourne, A Bilderbeck, L Abramovic, M P Boks, N E M van Haren, R A Ophoff, R S Kahn, M Bauer, A Pfennig, M Alda, T Hajek, B Mwangi, J C Soares, T Nickson, R Dimitrova, J E Sussmann, S Hagenaars, H C Whalley, A M McIntosh, P M Thompson, O A Andreassen
Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case-control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles...
February 9, 2016: Molecular Psychiatry
Claus D Volko, Pedro A Regidor, Uwe D Rohr
INTRODUCTION: Stress was described by Cushing and Selye as an adaptation to a foreign stressor by the anterior pituitary increasing ACTH, which stimulates the release of glucocorticoid and mineralocorticoid hormones. The question is raised whether stress can induce additional steroidal hormone cascade changes in severe mental diseases (SMD), since stress is the common denominator. METHODS: A systematic literature review was conducted in PubMed, where the steroidal hormone cascade of patients with SMD was compared to the impact of increasing stress on the steroidal hormone cascade (a) in healthy amateur marathon runners with no overtraining; (b) in healthy well-trained elite soldiers of a ranger training unit in North Norway, who were under extreme physical and mental stress, sleep deprivation, and insufficient calories for 1 week; and, (c) in soldiers suffering from post traumatic stress disorder (PTSD), schizophrenia (SI), and bipolar disorders (BD)...
March 2016: Hormone Molecular Biology and Clinical Investigation
I Hassouna, C Ott, L Wüstefeld, N Offen, R A Neher, M Mitkovski, D Winkler, S Sperling, L Fries, S Goebbels, I C Vreja, N Hagemeyer, M Dittrich, M F Rossetti, K Kröhnert, K Hannke, S Boretius, A Zeug, C Höschen, T Dandekar, E Dere, E Neher, S O Rizzoli, K-A Nave, A-L Sirén, H Ehrenreich
Recombinant human erythropoietin (EPO) improves cognitive performance in neuropsychiatric diseases ranging from schizophrenia and multiple sclerosis to major depression and bipolar disease. This consistent EPO effect on cognition is independent of its role in hematopoiesis. The cellular mechanisms of action in brain, however, have remained unclear. Here we studied healthy young mice and observed that 3-week EPO administration was associated with an increased number of pyramidal neurons and oligodendrocytes in the hippocampus of ~20%...
January 26, 2016: Molecular Psychiatry
J Wagenpfeil, C Schollig, V Mayer, B Nold, M Ederer, A Neugebauer, R Rothmund, B Kramer, C Schwentner, M Schenk, D Wallwiener, A Stenzl, M Enderle, O Sawodny, R Feuer
Radiofrequency-induced thermofusion is a frequently used electrosurgical procedure for the sealing of blood vessels. A disadvantage of vessel sealing instruments is that the generated thermal energy spreads to the surrounding tissue and may irreversibly damage it. This is particularly problematic when operating close to sensitive structures such as nerves. Given their advantages, there is nonetheless a lot of interest in using bipolar vessel sealing for surgical procedures. To select instruments that may be safely used in such cases, it is important to reliably quantify the thermal spread to the surrounding tissue...
August 2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
J J O Islas-García, J G Campos-Salcedo, B I López-Benjume, J J Torres-Gómez, J Aguilar-Colmenero, I A Martínez-Alonso, S A Gil-Villa
BACKGROUND: Bladder cancer is the second most common malignancy of the urinary tract and the 9th worldwide. Latin American has an incidence of 5.6 per 100,000 inhabitants per year. Seventy-five percent of newly diagnosed cases are nonmuscle invasive bladder cancer, and 25% of cases present as muscle invasive. The mainstay of treatment for nonmuscle invasive bladder cancer is loop transurethral resection. In 2013, the group led by Dr Mundhenk of the University Hospital of Tübingen, Germany, was the first to describe the Hybrid Knife(®) equipment for performing en bloc bladder tumour resection, with favourable functional and oncological results...
May 2016: Actas Urologicas Españolas
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