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Bipolar D/O

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https://www.readbyqxmd.com/read/28195573/whole-exome-sequencing-of-individuals-from-an-isolated-population-implicates-rare-risk-variants-in-bipolar-disorder
#1
F Lescai, T D Als, Q Li, M Nyegaard, G Andorsdottir, M Biskopstø, A Hedemand, A Fiorentino, N O'Brien, A Jarram, J Liang, J Grove, J Pallesen, E Eickhardt, M Mattheisen, L Bolund, D Demontis, A G Wang, A McQuillin, O Mors, J Wang, A D Børglum
Bipolar disorder affects about 1% of the world's population, and its estimated heritability is about 75%. Only few whole genome or whole-exome sequencing studies in bipolar disorder have been reported, and no rare coding variants have yet been robustly identified. The use of isolated populations might help finding variants with a recent origin, more likely to have drifted to higher frequency by chance. Following this approach, we investigated 28 bipolar cases and 214 controls from the Faroe Islands by whole exome sequencing, and the results were followed-up in a British sample of 2025 cases and 1358 controls...
February 14, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28168425/the-effects-of-histone-deacetylase-inhibition-on-the-levels-of-cerebral-cytokines-in-an-animal-model-of-mania-induced-by-dextroamphetamine
#2
Samira S Valvassori, Wilson R Resende, Roger B Varela, Camila O Arent, Fernanda F Gava, Bruna R Peterle, Gustavo C Dal-Pont, André F Carvalho, Monica L Andersen, João Quevedo
Studies have suggested the involvement of inflammatory processes in the physiopathology of bipolar disorder. Preclinical evidences have shown that histone deacetylase inhibitors may act as mood-stabilizing agents and protect the brain in models of mania and depression. The aim of the present study was to evaluate the effects of sodium butyrate (SB) and valproate (VPA) on behavioral changes, histone deacetylase activity, and the levels of cytokines in an animal model of mania induced by dextroamphetamine (d-AMPH)...
February 6, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28138157/forebrain-specific-ablation-of-phospholipase-c%C3%AE-1-causes-manic-like-behavior
#3
Y R Yang, J H Jung, S-J Kim, K Hamada, A Suzuki, H J Kim, J H Lee, O-B Kwon, Y K Lee, J Kim, E-K Kim, H-J Jang, D-S Kang, J-S Choi, C J Lee, J Marshall, H-Y Koh, C-J Kim, H Seok, S H Kim, J H Choi, Y-B Choi, L Cocco, S H Ryu, J-H Kim, P-G Suh
Manic episodes are one of the major diagnostic symptoms in a spectrum of neuropsychiatric disorders that include schizophrenia, obsessive-compulsive disorder and bipolar disorder (BD). Despite a possible association between BD and the gene encoding phospholipase Cγ1 (PLCG1), its etiological basis remains unclear. Here, we report that mice lacking phospholipase Cγ1 (PLCγ1) in the forebrain (Plcg1(f/f); CaMKII) exhibit hyperactivity, decreased anxiety-like behavior, reduced depressive-related behavior, hyperhedonia, hyperphagia, impaired learning and memory and exaggerated startle responses...
January 31, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28117838/early-onset-of-inflammation-during-ontogeny-of-bipolar-disorder-the-nlrp2-inflammasome-gene-distinctly-differentiates-between-patients-and-healthy-controls-in-the-transition-between-ips-cell-and-neural-stem-cell-stages
#4
D Vizlin-Hodzic, Q Zhai, S Illes, K Södersten, K Truvé, T Z Parris, P K Sobhan, S Salmela, S T Kosalai, C Kanduri, J Strandberg, H Seth, T O Bontell, E Hanse, H Ågren, K Funa
Neuro-inflammation and neuronal communication are considered as mis-regulated processes in the aetiology and pathology of bipolar disorder (BD). Which and when specific signal pathways become abnormal during the ontogeny of bipolar disorder patients is unknown. To address this question, we applied induced pluripotent stem cell (iPSC) technology followed by cortical neural differentiation on adipocyte-derived cells from BD type I patients (with psychotic episodes in psychiatric history) and healthy volunteers (controls)...
January 24, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28072414/evidence-for-genetic-heterogeneity-between-clinical-subtypes-of-bipolar-disorder
#5
A W Charney, D M Ruderfer, E A Stahl, J L Moran, K Chambert, R A Belliveau, L Forty, K Gordon-Smith, A Di Florio, P H Lee, E J Bromet, P F Buckley, M A Escamilla, A H Fanous, L J Fochtmann, D S Lehrer, D Malaspina, S R Marder, C P Morley, H Nicolini, D O Perkins, J J Rakofsky, M H Rapaport, H Medeiros, J L Sobell, E K Green, L Backlund, S E Bergen, A Juréus, M Schalling, P Lichtenstein, P Roussos, J A Knowles, I Jones, L A Jones, C M Hultman, R H Perlis, S M Purcell, S A McCarroll, C N Pato, M T Pato, N Craddock, M Landén, J W Smoller, P Sklar
We performed a genome-wide association study of 6447 bipolar disorder (BD) cases and 12 639 controls from the International Cohort Collection for Bipolar Disorder (ICCBD). Meta-analysis was performed with prior results from the Psychiatric Genomics Consortium Bipolar Disorder Working Group for a combined sample of 13 902 cases and 19 279 controls. We identified eight genome-wide significant, associated regions, including a novel associated region on chromosome 10 (rs10884920; P=3.28 × 10(-8)) that includes the brain-enriched cytoskeleton protein adducin 3 (ADD3), a non-coding RNA, and a neuropeptide-specific aminopeptidase P (XPNPEP1)...
January 10, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/27930497/the-comt-val158met-polymorphism-is-associated-with-response-to-add-on-dextromethorphan-treatment-in-bipolar-disorder
#6
Sheng-Yu Lee, Shiou-Lan Chen, Tzu-Yun Wang, Yun-Hsuan Chang, Po See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Liang-Jen Wang, I Hui Lee, Kao Ching Chen, Yen Kuang Yang, Ru-Band Lu
PURPOSE/BACKGROUND: We previously conducted a randomized, double-blind, controlled, 12-week study evaluating the effect of add-on dextromethorphan (DM), a noncompetitive N-methyl-D-aspartate receptor antagonist, on patients with bipolar disorder (BD) treated using valproate (VPA), which showed negative clinical differences. The genetic variation between each individual may be responsible for interindividual differences. The catechol-O-methyltransferase (COMT) gene has been a candidate gene for BD...
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27894373/cognitive-effects-of-adjunctive-n-acetyl-cysteine-in-psychosis
#7
M Rapado-Castro, S Dodd, A I Bush, G S Malhi, D R Skvarc, Z X On, M Berk, O M Dean
BACKGROUND: Cognitive deficits are predictors of functional outcome in patients with psychosis. While conventional antipsychotics are relatively effective on positive symptoms, their impact on negative and cognitive symptoms is limited. Recent studies have established a link between oxidative stress and neurocognitive deficits in psychosis. N-acetylcysteine (NAC), a glutathione precursor with glutamatergic properties, has shown efficacy on negative symptoms and functioning in patients with schizophrenia and bipolar disorder, respectively...
November 29, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27845315/-agomelatine-valdoxan-in-treatment-of-endogenous-depression-in-day-patient-department
#8
E V Chernova, O V Kozhechkina, A Yu Ter-Israelyan, V E Medvedev
AIM: Naturalistic psychopharmacological study of efficacy and tolerability of agomelatine (valdoxan) in treatment of endogenous depressions (in the framework of schizophrenia, schizoaffective and bipolar disorder) in day patient department. MATERIAL AND METHODS: Study sample consisted of 37 patient (59.4% female, mean age 41.6±3.7 years). RESULTS AND CONCLUSION: CDS total score significantly reduced after 8 weeks of treatment 44.9% compared to baseline (р<0...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27834153/childhood-trauma-is-associated-with-increased-brain-responses-to-emotionally-negative-as-compared-with-positive-faces-in-patients-with-psychotic-disorders
#9
M Aas, K Kauppi, C L Brandt, M Tesli, T Kaufmann, N E Steen, I Agartz, L T Westlye, O A Andreassen, I Melle
BACKGROUND: Childhood trauma increases risk of a range of mental disorders including psychosis. Whereas the mechanisms are unclear, previous evidence has implicated atypical processing of emotions among the core cognitive models, in particular suggesting altered attentional allocation towards negative stimuli and increased negativity bias. Here, we tested the association between childhood trauma and brain activation during emotional face processing in patients diagnosed with psychosis continuum disorders...
November 11, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27830632/alcohol-use-is-associated-with-thinner-cerebral-cortex-and-larger-ventricles-in-schizophrenia-bipolar-disorder-and-healthy-controls
#10
E H Lange, S Nerland, K N Jørgensen, L Mørch-Johnsen, R Nesvåg, C B Hartberg, U K Haukvik, K Osnes, I Melle, O A Andreassen, I Agartz
BACKGROUND: Excessive alcohol use is associated with brain damage but less is known about brain effects from moderate alcohol use. Previous findings indicate that patients with severe mental illness, particularly schizophrenia, are vulnerable to alcohol-related brain damage. We investigated the association between levels of alcohol consumption and cortical and subcortical brain structures in schizophrenia and bipolar disorder patients and healthy controls, and investigated for group differences for this association...
November 10, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27772831/bipolar-radiofrequency-ablation-for-thyroid-nodules-with-effective-induction-of-sufficiently-large-lesions-without-danger-to-surrounding-structures-ex-vivo-morphological-evaluation
#11
D I Branovan, M Fridman, O Krasko, M Lushchik, V Drozd, N Shiglik, L Danilova, Y Demidchik
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27721184/liraglutide-promotes-improvements-in-objective-measures-of-cognitive-dysfunction-in-individuals-with-mood-disorders-a-pilot-open-label-study
#12
Rodrigo B Mansur, Juhie Ahmed, Danielle S Cha, Hanna O Woldeyohannes, Mehala Subramaniapillai, Julie Lovshin, Jung G Lee, Jae-Hon Lee, Elisa Brietzke, Eva Z Reininghaus, Kang Sim, Maj Vinberg, Natalie Rasgon, Tomas Hajek, Roger S McIntyre
BACKGROUND: There is a paucity of treatments that are capable of reliably and robustly improving cognitive function in adults with mood disorders. Glucagon-like peptide-1 is synthesized centrally and its receptors are abundantly expressed in neural circuits subserving cognitive function. We aimed to determine the effects of liraglutide, a GLP-1 receptor (GLP-1R) agonist, on objective measures of cognition in adults with a depressive or bipolar disorder. METHODS: In this 4-week, pilot, open-label, domain-based study (e...
January 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27622935/evidence-that-comt-genotype-and-proline-interact-on-negative-symptom-outcomes-in-schizophrenia-and-bipolar-disorder
#13
C L Clelland, V Drouet, K C Rilett, J A Smeed, R H Nadrich, A Rajparia, L L Read, J D Clelland
Elevated peripheral proline is associated with psychiatric disorders, and there is evidence that proline is a neuromodulator. The proline dehydrogenase (PRODH) gene, which encodes the enzyme that catalyzes proline catabolism, maps to human chromosome 22q11.2, a region conferring risk of schizophrenia. In the Prodh-null mouse, an interaction between elevated peripheral proline and another 22q11.2 gene, catechol-O-methyltransferase (COMT), on neurotransmission and behavior has been reported. We explored the relationship between fasting plasma proline levels and COMT Val(158)Met genotype on symptoms (positive, negative and total) in schizophrenia patients...
September 13, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27576186/brain-hyper-excitability-revealed-by-optimal-electrical-stimulation-of-gabaergic-interneurons
#14
F Wendling, U Gerber, D Cosandier-Rimele, A Nica, J De Montigny, O Raineteau, S Kalitzin, F Lopes da Silva, P Benquet
BACKGROUND: Neurological disorders are often characterized by an excessive and prolonged imbalance between neural excitatory and inhibitory processes. An ubiquitous finding among these disorders is the disrupted function of inhibitory GABAergic interneurons. OBJECTIVE: The objective is to propose a novel stimulation procedure able to evaluate the efficacy of inhibition imposed by GABAergic interneurons onto pyramidal cells from evoked responses observed in local field potentials (LFPs)...
November 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27524481/mismatch-of-synaptic-patterns-between-neurons-produced-in-regeneration-and-during-development-of-the-vertebrate-retina
#15
Florence D D'Orazi, Xiao-Feng Zhao, Rachel O Wong, Takeshi Yoshimatsu
Stereotypic patterns of synaptic connections between neurons underlie the ability of the CNS to perform complex but circuit-specific information processing. Tremendous progress has been made toward advancing our understanding of how circuits are assembled during development, but whether the precision of this process can be recaptured after regeneration of neurons in the damaged CNS remains unclear. Here, we harnessed the endogenous regenerative capacity of the zebrafish retina to reconstruct the circuitry of neurons produced after damage...
September 12, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27457814/sorcs2-is-required-for-bdnf-dependent-plasticity-in-the-hippocampus
#16
S Glerup, U Bolcho, S Mølgaard, S Bøggild, C B Vaegter, A H Smith, J L Nieto-Gonzalez, P L Ovesen, L F Pedersen, A N Fjorback, M Kjolby, H Login, M M Holm, O M Andersen, J R Nyengaard, T E Willnow, K Jensen, A Nykjaer
SorCS2 is a member of the Vps10p-domain receptor gene family receptors with critical roles in the control of neuronal viability and function. Several genetic studies have suggested SORCS2 to confer risk of bipolar disorder, schizophrenia and attention deficit-hyperactivity disorder. Here we report that hippocampal N-methyl-d-aspartate receptor-dependent synaptic plasticity is eliminated in SorCS2-deficient mice. This defect was traced to the ability of SorCS2 to form complexes with the neurotrophin receptor p75(NTR), required for pro-brain-derived neurotrophic factor (BDNF) to induce long-term depression, and with the BDNF receptor tyrosine kinase TrkB to elicit long-term potentiation...
December 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27416076/single-residue-aav-capsid-mutation-improves-transduction-of-photoreceptors-in-the-abca4-mouse-and-bipolar-cells-in-the-rd1-mouse-and-human-retina-ex-vivo
#17
S R De Silva, P Charbel Issa, M S Singh, D M Lipinski, A O Barnea-Cramer, N J Walker, A R Barnard, M W Hankins, R E MacLaren
Gene therapy using adeno-associated viral (AAV) vectors for the treatment of retinal degenerations has shown safety and efficacy in clinical trials. However, very high levels of vector expression may be necessary for the treatment of conditions such as Stargardt disease where a dual vector approach is potentially needed, or in optogenetic strategies for end-stage degeneration in order to achieve maximal light sensitivity. In this study, we assessed two vectors with single capsid mutations, rAAV2/2(Y444F) and rAAV2/8(Y733F) in their ability to transduce retina in the Abca4(-/-) and rd1 mouse models of retinal degeneration...
November 2016: Gene Therapy
https://www.readbyqxmd.com/read/27349652/birth-by-cesarean-section-and-schizophrenia-results-from-the-multicenter-face-sz-data-set
#18
G Fond, E Bulzacka, L Boyer, P M Llorca, O Godin, L Brunel, M G Andrianarisoa, B Aouizerate, F Berna, D Capdevielle, I Chereau, H Denizot, J M Dorey, C Dubertret, J Dubreucq, C Faget, F Gabayet, Y Le Strat, J A Micoulaud-Franchi, D Misdrahi, R Rey, R Richieri, M Roger, C Passerieux, A Schandrin, M Urbach, P Vidalhet, F Schürhoff, M Leboyer
Children born by cesarean section ("c-birth") are known to have different microbiota and a natural history of different disorders including allergy, asthma and overweight compared to vaginally born ("v-birth") children. C-birth is not known to increase the risk of schizophrenia (SZ), but to be associated with an earlier age at onset. To further explore possible links between c-birth and SZ, we compared clinical and biological characteristics of c-born SZ patients compared to v-born ones. Four hundred and fifty-four stable community-dwelling SZ patients (mean age = 32...
June 27, 2016: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/27299091/simultaneous-bilateral-femur-neck-fracture-in-a-young-adult-with-chronic-renal-failure-a-case-report-and-review-of-literature
#19
Sathyanarayana V, Maulik Tulsibhai Patel, Raghavan S, Naresh D
INTRODUCTION: Pathological bilateral femoral neck fracture due to renal osteodystrophy is rare. This is a report of a chronic renal failure patient who had sustained bilateral intra-capsular displaced fracture neck of femur following an episode of convulsion and the difficulties encountered in early diagnosis and treatment. The pathophysiology of renal osteodystrophy and the treatment of hip fractures in patients with renal failure are also discussed. CASE REPORT: A 23 years old male patient admitted with h/o dysuria, pyuria and loss of appetite since 3 months...
October 2015: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/27291558/comparing-the-short-term-outcomes-and-complications-of-monopolar-and-bipolar-transurethral-resection-of-non-muscle-invasive-bladder-cancers-a-prospective-randomized-controlled-study
#20
RANDOMIZED CONTROLLED TRIAL
Deniz Bolat, Bulent Gunlusoy, Tansu Degirmenci, Yasin Ceylan, Salih Polat, Erhan Aydin, Ozgu Aydogdu, Zafer Kozacioglu
OBJECTIVES: To compare perioperative outcomes and complications of plasmakinetic bipolar and monopolar transurethral resection of bladder tumors (TURBT) in patients with non-muscle invasive bladder cancer (NMIBC). METHODS: Between March and December 2015, a total of 130 consecutive patients underwent TURBT for NMIBC. Patients were equally randomized into monopolar TURBT (M-TURBT) and bipolar TURBT (B-TURBT) groups. Primary outcome of this study was safety of the procedures including obturator jerk, bladder perforation, clot retention, febrile urinary tract infection and TUR syndrome...
June 2016: Archivos Españoles de Urología
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