keyword
https://read.qxmd.com/read/38546628/the-hierarchical-taxonomy-of-psychopathology-in-clinical-high-risk-for-psychosis-validation-and-extension
#1
JOURNAL ARTICLE
Trevor F Williams, Alexander L Williams, Henry R Cowan, Elaine F Walker, Tyrone D Cannon, Carrie E Bearden, Matcheri Keshavan, Barbara A Cornblatt, Jean Addington, Scott W Woods, Diana O Perkins, Daniel H Mathalon, Kristin S Cadenhead, William S Stone, Vijay A Mittal
The Hierarchical Taxonomy of Psychopathology (HiTOP) consortium's transdiagnostic dimensional model of psychopathology has considerable support; however, this model has been underresearched in individuals at clinical high risk for psychosis (CHR-P), a population that may advance the model. CHR-P individuals not only have attenuated psychotic symptoms that vary in severity, but also have many comorbid diagnoses and varied clinical outcomes, including disorders with uncertain relations to HiTOP (e.g., obsessive-compulsive disorder)...
March 28, 2024: J Psychopathol Clin Sci
https://read.qxmd.com/read/38529873/-a-clinical-case-of-the-new-onset-bipolar-affective-disorder-in-the-postcovid-period
#2
JOURNAL ARTICLE
M N Dmitriev, D O Baeva, M S Slavgorodskaya
A large number of people who have had COVID-19 have developed mental symptoms and mood disorders. Anxiety and depression prevail among affective pathology. Evidence is accumulating that the Sars-CoV-2 virus can induce mania or hypomania in people with no personal psychopathological history. Some clinical, anamnestic and paraclinical patterns of new-onset mania and hypomania have been found. In cases of severe manic symptoms, it is possible to quickly assume the occurrence of bipolar affective disorder. The predominance of depressive and anxiety syndromes in the long-term disease and the presence of vivid vegetative symptoms can mask brief and syndromally incomplete episodes of hypomania, which distorts the understanding of the disease as a bipolar disorder...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38437739/next-generation-3-3-alkoxybtps-as-complexants-for-minor-actinide-separation-from-lanthanides-a-comprehensive-separations-spectroscopic-and-dft-study
#3
JOURNAL ARTICLE
Lesta S Fletcher, Mariah L Tedder, Samiat O Olayiwola, Nickolas A Joyner, Marcos M Mason, Allen G Oliver, Dale D Ensor, David A Dixon, Jesse D Carrick
Progress toward the closure of the nuclear fuel cycle can be achieved if satisfactory separation strategies for the chemoselective speciation of the trivalent actinides from the lanthanides are realized in a nonproliferative manner. Since Kolarik's initial report on the utility of bis-1,2,4-triazinyl-2,6-pyridines (BTPs) in 1999, a perfect complexant-based, liquid-liquid separation system has yet to be realized. In this report, a comprehensive performance assessment for the separation of 241 Am3+ from 154 Eu3+ as a model system for spent nuclear fuel using hydrocarbon-actuated alkoxy-BTP complexants is described...
March 4, 2024: Inorganic Chemistry
https://read.qxmd.com/read/38405768/fine-mapping-genomic-loci-refines-bipolar-disorder-risk-genes
#4
Maria Koromina, Ashvin Ravi, Georgia Panagiotaropoulou, Brian M Schilder, Jack Humphrey, Alice Braun, Tim Bidgeli, Chris Chatzinakos, Brandon Coombes, Jaeyoung Kim, Xiaoxi Liu, Chikashi Terao, Kevin S O 'Connell, Mark Adams, Rolf Adolfsson, Martin Alda, Lars Alfredsson, Till F M Andlauer, Ole A Andreassen, Anastasia Antoniou, Bernhard T Baune, Susanne Bengesser, Joanna Biernacka, Michael Boehnke, Rosa Bosch, Murray Cairns, Vaughan J Carr, Miquel Casas, Stanley Catts, Sven Cichon, Aiden Corvin, Nicholas Craddock, Konstantinos Dafnas, Nina Dalkner, Udo Dannlowski, Franziska Degenhardt, Arianna Di Florio, Dimitris Dikeos, Frederike Tabea Fellendorf, Panagiotis Ferentinos, Andreas J Forstner, Liz Forty, Mark Frye, Janice M Fullerton, Micha Gawlik, Ian R Gizer, Katherine Gordon-Smith, Melissa J Green, Maria Grigoroiu-Serbanescu, José Guzman-Parra, Tim Hahn, Frans Henskens, Jan Hillert, Assen V Jablensky, Lisa Jones, Ian Jones, Lina Jonsson, John R Kelsoe, Tilo Kircher, George Kirov, Sarah Kittel-Schneider, Manolis Kogevinas, Mikael Landén, Marion Leboyer, Melanie Lenger, Jolanta Lissowska, Christine Lochner, Carmel Loughland, Donald MacIntyre, Nicholas G Martin, Eirini Maratou, Carol A Mathews, Fermin Mayoral, Susan L McElroy, Nathaniel W McGregor, Andrew McIntosh, Andrew McQuillin, Patricia Michie, Vihra Milanova, Philip B Mitchell, Paraskevi Moutsatsou, Bryan Mowry, Bertram Müller-Myhsok, Richard Myers, Igor Nenadić, Markus M Nöthen, Claire O'Donovan, Michael O'Donovan, Roel A Ophoff, Michael J Owen, Chris Pantelis, Carlos Pato, Michele T Pato, George P Patrinos, Joanna M Pawlak, Roy H Perlis, Evgenia Porichi, Danielle Posthuma, Josep Antoni Ramos-Quiroga, Andreas Reif, Eva Z Reininghaus, Marta Ribasés, Marcella Rietschel, Ulrich Schall, Thomas G Schulze, Laura Scott, Rodney J Scott, Alessandro Serretti, Cynthia Shannon Weickert, Jordan W Smoller, Maria Soler Artigas, Dan J Stein, Fabian Streit, Claudio Toma, Paul Tooney, Eduard Vieta, John B Vincent, Irwin D Waldman, Thomas Weickert, Stephanie H Witt, Kyung Sue Hong, Masashi Ikeda, Nakao Iwata, Beata Świątkowska, Hong-Hee Won, Howard J Edenberg, Stephan Ripke, Towfique Raj, Jonathan R I Coleman, Niamh Mullins
Bipolar disorder (BD) is a heritable mental illness with complex etiology. While the largest published genome-wide association study identified 64 BD risk loci, the causal SNPs and genes within these loci remain unknown. We applied a suite of statistical and functional fine-mapping methods to these loci, and prioritized 22 likely causal SNPs for BD. We mapped these SNPs to genes, and investigated their likely functional consequences by integrating variant annotations, brain cell-type epigenomic annotations, brain quantitative trait loci, and results from rare variant exome sequencing in BD...
February 13, 2024: medRxiv
https://read.qxmd.com/read/38258528/inducing-abundant-magnetic-phases-and-enhancing-magnetic-stability-by-edge-modifications-and-physical-regulations-for-nii-2-nanoribbons
#5
JOURNAL ARTICLE
Yu Yi, Jianing Han, Zhanhai Li, Shengguo Cao, Zhenhua Zhang
Recently, a magnetic semiconducting NiI2 monolayer was successfully fabricated. To obtain richer magneto-electronic properties and find new physics for NiI2 , we studied the zigzag-type NiI2 nanoribbon (ZNiI2 NR) with edges modified by different concentrations of H and/or O atoms. Results show that these ribbons hold a higher energy stability, thermal stability, and magnetic stability, and the Curie temperature can be increased to 143 from 15 K for the bare-edged ribbons. They feature a half-semiconductor, bipolar magnetic semiconductor, or half-metal, depending on the edge-terminated atomic species and concentrations, and are closely related to the ribbon edge states, impurity bands or hybridized bands...
January 23, 2024: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/37900490/illuminating-hope-for-mental-health-a-drug-review-on-lumateperone
#6
REVIEW
Martin Tarzian, Mariana Ndrio, Byron Chique, Japjit Serai, Bryce Thalackal, Jessi Lau, Adegbenro O Fakoya
This drug review provides a comprehensive analysis of a novel antipsychotic called lumateperone, marketed as Caplyta. Lumateperone gained FDA approval in 2019 for treating schizophrenia and later, in 2021, for treating bipolar depression. The review begins by delving into lumateperone's mechanism of action, which involves the partial agonism of the dopamine D2 receptor as well as its unique effects on the dopamine transporter, N-methyl-D-aspartate (NMDA) receptor, and serotonin transporter. Additionally, the study examines lumateperone's distinctive pharmacokinetics...
September 2023: Curēus
https://read.qxmd.com/read/37833512/cross-species-review-of-the-physiological-role-of-d-serine-in-translationally-relevant-behaviors
#7
REVIEW
Dena Arizanovska, Jada A Emodogo, Anna P Lally, Caroline B Palavicino-Maggio, Daniel J Liebl, Oluwarotimi O Folorunso
Bridging the gap between preclinical models of neurological and psychiatric disorders with their human manifestations is necessary to understand their underlying mechanisms, identify biomarkers, and develop novel therapeutics. Cognitive and social impairments underlie multiple neuropsychiatric and neurological disorders and are often comorbid with sleep disturbances, which can exacerbate poor outcomes. Importantly, many symptoms are conserved between vertebrates and invertebrates, although they may have subtle differences...
November 2023: Amino Acids
https://read.qxmd.com/read/37826875/effect-of-lithium-in-pyramidal-neurons-of-cornu-ammonis-in-an-animal-model
#8
JOURNAL ARTICLE
G P Ossani, M A Riudavets, V D'Annunzio, A M Uceda, O Ponzo, N R Lago, D J Martino
Bipolar disorder has been associated with a decrease in hippocampal size, and lithium appears to reverse this neuroanatomical abnormality. The objective of this work was to evaluate, at a cellular level, the size of both cell body and nucleus of pyramidal neurons located throughout the Cornu Ammonis (CA1 to CA4 regions). To perform this duty, we used 16 rats that were randomized into two groups: control and dietary lithium-treated. After one month, they were sacrificed and their brains removed for histopathological analysis...
October 5, 2023: Journal of Psychiatric Research
https://read.qxmd.com/read/37771914/ancient-origin-of-the-rod-bipolar-cell-pathway-in-the-vertebrate-retina
#9
Ayana M Hellevik, Philip Mardoum, Joshua Hahn, Yvonne Kölsch, Florence D D'Orazi, Sachihiro C Suzuki, Leanne Godinho, Owen Lawrence, Fred Rieke, Karthik Shekhar, Joshua R Sanes, Herwig Baier, Tom Baden, Rachel O Wong, Takeshi Yoshimatsu
UNLABELLED: Vertebrates rely on rod photoreceptors for vision in low-light conditions 1 . Mammals have a specialized downstream circuit for rod signaling called the primary rod pathway, which comprises specific cell types and wiring patterns that are thought to be unique to this lineage 2-6 . Thus, it has been long assumed that the primary rod pathway evolved in mammals 3, 5-7 . Here, we challenge this view by demonstrating that the mammalian primary rod pathway is conserved in zebrafish, which diverged from extant mammals ∼400 million years ago...
September 13, 2023: bioRxiv
https://read.qxmd.com/read/37582993/nonselective-expression-of-short-wavelength-cone-opsin-improves-learning-in-mice-with-retinal-degeneration-in-a-visually-guided-task
#10
JOURNAL ARTICLE
O S Idzhilova, D E Kolotova, G R Smirnova, A Abonakour, D A Dolgikh, L E Petrovskaya, M P Kirpichnikov, M A Ostrovsky, A Yu Malyshev
The study explored the potential of an animal opsin nonselectively expressed in various neuronal elements of the degenerative retina to restore the impaired visual function. A knockout murine model of inherited retinal dystrophy was used. Mice were injected intravitreally with either a virus carrying the gene of short-wavelength cone opsin associated with a reporter fluorescent protein or a control virus carrying the sequence of a modified fluorescent protein with enhanced membrane tropism. Viral transduction induced pronounced opsin expression in ganglion, bipolar, and horizontal retinal neurons...
June 2023: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://read.qxmd.com/read/37205452/kappa-opioid-receptor-antagonism-rescues-genetic-perturbation-of-dopamine-homeostasis-molecular-physiological-and-behavioral-consequences
#11
Felix P Mayer, Adele Stewart, Durairaj Ragu Varman, Amy E Moritz, James D Foster, Anthony W Owens, Lorena B Areal, Raajaram Gowrishankar, Michelle Velez, Kyria Wickham, Hannah Phelps, Rania Katamish, Maximilian Rabil, Lankupalle D Jayanthi, Roxanne A Vaughan, Lynette C Daws, Randy D Blakely, Sammanda Ramamoorthy
Aberrant dopamine (DA) signaling is implicated in schizophrenia, bipolar disorder (BPD), autism spectrum disorder (ASD), substance use disorder, and attention-deficit/hyperactivity disorder (ADHD). Treatment of these disorders remains inadequate. We established that the human DA transporter (DAT) coding variant (DAT Val559), identified in individuals with ADHD, ASD, or BPD, exhibits anomalous DA efflux (ADE) that is blocked by therapeutic amphetamines and methylphenidate. As the latter agents have high abuse liability, we exploited DAT Val559 knock-in mice to identify non-addictive agents that can normalize DAT Val559 functional and behavioral effects ex viv o and in vivo ...
May 3, 2023: bioRxiv
https://read.qxmd.com/read/37141132/-association-of-depression-and-anxiety-with-somatic-diseases-negative-lifestyle-factors-impact
#12
JOURNAL ARTICLE
G V Rukavishnikov, A S Rakitko, E D Kasyanov, V V Ilinsky, L V Malyshko, N G Neznanov, A O Kibitov, G E Mazo
OBJECTIVE: To assess the associations of various depression and anxiety phenotypes with manifestations of different somatic disorders and negative lifestyle factors. MATERIAL AND METHODS: The study involved 5116 people. In the online questionnaire, participants provided information about age, sex, height and weight, as well as a history of smoking, alcohol use, physical activity and diagnoses/symptoms of various physical diseases. Self-questions based on the DSM-5 criteria and the online version of the HADS were used to screen for phenotypes of affective and anxiety disorders in a population sample...
2023: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/37084362/-a-role-of-neurosteroids-in-the-pathogenesis-of-psychiatric-disorders
#13
REVIEW
D S Petelin, S P Bairamova, R V Akhapkin, N V Kudryashov, O Yu Sorokina, S A Semin, B A Volel
Despite the proven importance of neurosteroids in many physiological processes, their role in the pathogenesis of the most of psychiatric disorders remains relatively understudied. This article reviews the current clinical evidence on the effects of neurosteroids on the formation and treatment of anxiety disorder, depression, bipolar disorder, and schizophrenia. In particular, the article points out the ambivalent nature of the effects of neurosteroids on GABAA - and other receptors. We are especially interested in the anxiolytic and anxiogenic effects of some neurosteroids, the antidepressant effect of allopregnanolone in treating postpartum and other forms of depression, and the nature of short- and long-term mechanisms of antidepressant effects of neurosteroids of different types...
2023: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/37046974/pharmacological-modulation-of-temporal-discounting-a-systematic-review
#14
REVIEW
Luis Felipe Sarmiento, Jorge Alexander Ríos-Flórez, Hector Andres Paez-Ardila, Pêssi Socorro Lima de Sousa, Antonio Olivera-La Rosa, Anderson Manoel Herculano Oliveira da Silva, Amauri Gouveia
Temporal discounting is a phenomenon where a reward loses its value as a function of time (e.g., a reward is more valuable immediately than when it delays in time). This is a type of intertemporal decision-making that has an association with impulsivity and self-control. Many pathologies exhibit higher discounting rates, meaning they discount more the values of rewards, such as addictive behaviors, bipolar disorder, attention-deficit/hyperactivity disorders, social anxiety disorders, and major depressive disorder, among others; thus, many studies look for the mechanism and neuromodulators of these decisions...
April 6, 2023: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/36881916/effects-of-thymoquinone-on-spinal-cord-injury-in-rats
#15
JOURNAL ARTICLE
Ö Avınca, M Taş, Y Karakoç, D Yavuz, E Deveci
PURPOSE: Spinal cord injury (SCI) is a condition that causes disturbances in normal sensory, motor, and autonomic functions. During SCI, damages occur such as, contusion, compression, distraction. The aim of this study was to investigate effects of the antioxidative thymoquinone on neuron and glia cells in SCI biochemically, immunohistochemically and ultrastructurally. METHODS: Male Sprague-Dawley rats were divided into Control, SCI and SCI + Thymoquinone groups...
December 1, 2022: Archives Italiennes de Biologie
https://read.qxmd.com/read/36690794/does-treatment-with-autophagy-enhancers-and-or-ros-scavengers-alleviate-behavioral-and-neurochemical-consequences-of-low-dose-rotenone-induced-mild-mitochondrial-dysfunction-in-mice
#16
JOURNAL ARTICLE
O Damri, S Natour, S Asslih, G Agam
Bipolar-disorder's pathophysiology and the mechanism by which medications exert their beneficial effect is yet unknown, but others' and our data implicate patients' brain mitochondrial-dysfunction and its amendment by mood-stabilizers. We recently designed a novel mouse bipolar-disorder-like model using chronic administration of a low-dose of the oxidative-phosphorylation complex I inhibitor, rotenone. Four and eight weeks rotenone treatment induced manic- and depressive-like behavior, respectively, accompanied by mood-related neurochemical changes...
January 23, 2023: Molecular Psychiatry
https://read.qxmd.com/read/36637001/long-term-treatment-of-adult-adhd-in-a-naturalistic-setting-clinical-predictors-of-attrition-medication-choice-improvement-and-response
#17
JOURNAL ARTICLE
Giulio Emilio Brancati, Francesco De Dominicis, Alessandra Petrucci, Alessandro Pallucchini, Marco Carli, Pierpaolo Medda, Elisa Schiavi, Pietro De Rossi, Stefano Vicari, Giulio Perugi
Objectives: The aim of this study was to identify clinical predictors of treatment attrition, medication choice, improvement and response to pharmacotherapy in adult attention-deficit/hyperactivity disorder (ADHD). Methods: 150 ADHD patients were enrolled and naturalistically followed-up for at least 4 months. Conners' Adult ADHD Rating Scales-Observer: Screening Version (CAARS-O:SV) were used to measure ADHD severity. Results: 58 subjects (38.7%) were lost at follow-up, while 75 (50%) completed follow-up assessment, on average after 26...
January 13, 2023: World Journal of Biological Psychiatry
https://read.qxmd.com/read/36369423/coordinated-cortical-thickness-alterations-across-six-neurodevelopmental-and-psychiatric-disorders
#18
JOURNAL ARTICLE
M D Hettwer, S Larivière, B Y Park, O A van den Heuvel, L Schmaal, O A Andreassen, C R K Ching, M Hoogman, J Buitelaar, D van Rooij, D J Veltman, D J Stein, B Franke, T G M van Erp, N Jahanshad, P M Thompson, S I Thomopoulos, R A I Bethlehem, B C Bernhardt, S B Eickhoff, S L Valk
Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations covary in a biologically meaningful way is currently unknown. Here, we studied co-alteration networks across six neurodevelopmental and psychiatric disorders, reflecting pathological structural covariance. In 12,024 patients and 18,969 controls from the ENIGMA consortium, we observed that co-alteration patterns followed normative connectome organization and were anchored to prefrontal and temporal disease epicenters...
November 11, 2022: Nature Communications
https://read.qxmd.com/read/36220840/working-memory-updating-in-individuals-with-bipolar-and-unipolar-depression-fmri-study
#19
JOURNAL ARTICLE
Anna Manelis, Yaroslav O Halchenko, Lisa Bonar, Richelle S Stiffler, Skye Satz, Rachel Miceli, Cecile D Ladouceur, Genna Bebko, Satish Iyengar, Holly A Swartz, Mary L Phillips
Understanding neurobiological characteristics of cognitive dysfunction in distinct psychiatric disorders remains challenging. In this secondary data analysis, we examined neurobiological differences in brain response during working memory updating among individuals with bipolar disorder (BD), those with unipolar depression (UD), and healthy controls (HC). Individuals between 18-45 years of age with BD (n = 100), UD (n = 109), and HC (n = 172) were scanned using fMRI while performing 0-back (easy) and 2-back (difficult) tasks with letters as the stimuli and happy, fearful, or neutral faces as distractors...
October 11, 2022: Translational Psychiatry
https://read.qxmd.com/read/35950614/epitope-fine-mapping-by-mass-spectrometry-investigations-of-immune-complexes-consisting-of-monoclonal-anti-hptgekp-antibody-and-zinc-finger-protein-linker-phospho-hexapeptides
#20
JOURNAL ARTICLE
Maximilian Scherf, Bright D Danquah, Cornelia Koy, Peter Lorenz, Felix Steinbeck, Andrei Neamtu, Hans-Jürgen Thiesen, Michael O Glocker
Accurate formation of antibody - antigen complexes has been relied on in both, multitudes of scientific projects and ample therapeutic and diagnostic applications. Mass spectrometrically-determined dissociation behavior of immune complexes with the antiHpTGEKP antibody revealed that the ten most frequently occur-ring phospho-hexapeptide linker sequences from C2H2 zinc finger proteins could be divided into two classes: orthodox binders, where strong non-covalent interactions developed as anticipated, and unorthodox binders with deviating structures and weaker binding...
August 11, 2022: Chembiochem: a European Journal of Chemical Biology
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