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https://www.readbyqxmd.com/read/28811566/injectable-phosphorescence-based-oxygen-biosensors-identify-post-ischemic-reactive-hyperoxia
#1
Jennifer S Chien, Mahmoud Mohammed, Hysem Eldik, Mohamed M Ibrahim, Jeremy Martinez, Scott P Nichols, Natalie Wisniewski, Bruce Klitzman
Novel injectable biosensors were used to measure interstitial oxygenation before, during, and after transient ischemia. It is well known that reactive hyperemia occurs following a period of ischemia. However, increased blood flow does not necessarily mean increased oxygen tension in the tissue. Therefore, the purpose of this study was to test the hypothesis that tissue reactive hyperoxia occurs following release of hind-limb tourniquet occlusions. Rats were injected with bilateral hind-limb biosensors and were simultaneously subjected to a unilateral femoral vessel ligation...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28803174/intraoperative-vascular-neuromonitoring-in-patients-with-subarachnoid-hemorrhage-a-pilot-study-using-combined-laser-doppler-spectrophotometry
#2
Emilija Schmitz, Barbara Bischoff, Dennis Wolf, Hubert Schmitt, Ilker Y Eyupoglu, Karl Roessler, Michael Buchfelder, Björn Sommer
OBJECTIVE: Intraoperative monitoring of cerebral microcirculation in patients with subarachnoid hemorrhage (SAH) may predict the postoperative neurological outcome. In this pilot study, we examined the value of a novel non-invasive real-time measurement technique to detect changes in local microcirculation. METHODS: We used the laser-Doppler spectrophotometry system "Oxygen-to-see(O2C)" in 14 patients with SAH Hunt & Hess grade 2 to 5, who underwent microsurgical clipping of cerebral aneurysms...
August 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28802566/alcohol-use-and-cardiovascular-disease-risk-in-patients-with-nonalcoholic-fatty-liver-disease
#3
Lisa B VanWagner, Hongyan Ning, Norrina B Allen, Veeral Ajmera, Cora E Lewis, John Jeffrey Carr, Donald M Lloyd-Jones, Norah A Terrault, Juned Siddique
BACKGROUND & AIMS: Cardiovascular disease (CVD) is the leading cause of death among patients with non-alcoholic fatty liver disease (NAFLD). Moderate drinking (vs abstinence) is associated with lower risk of CVD in the general population. We assessed whether alcohol use is associated with CVD risk in patients with NAFLD. METHODS: We analyzed data from participants in the Coronary Artery Risk Development in Young Adults longitudinal cohort study of 5115 black and white young adults, 18-30 years old, recruited from 4 cities in the United States from 1985 through 1986...
August 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28801284/-yiqihuoxue-prescription-promotes-nerve-regeneration-by-mir-124-mediated-regulation-of-wnt-signaling-in-rats
#4
Hui Tan, Jian Wang, Ting-Ting Yin, Ling He, Yong Deng, Feng Li, Yu-Feng Wang
OBJECTIVE: To investigate the effect of Yiqihuoxue prescription (NLXT) on nerve regeneration in MCAO-R rat models of qi deficiency and blood stasis syndrome and explore the underlying mechanisms. METHODS: The rats were randomized into 4 groups, namely the control group, model group, NLXT group and TXL group. The rats in NLXT group and TXL group were treated with gavage of NLXT and TXL solutions, respectively. The NFDS, QDSS and BSSS of the rats were evaluated. The regional cerebral blood flow (rCBF) were dynamically monitored with laser Doppler scanning, and the volume of cerebral infarction was detected with TTC-dye; the expression levels of nestin and BrdU were assayed with immunohistochemistry and mmunofluorescent staining...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28801279/-high-frequency-echocardiography-for-assessment-of-regional-wall-motion-abnormality-and-cardiac-function-in-mice-with-myocardial-infarction
#5
Jing Wang, Wei-Jiang Tan, Xiang Li, Gui-Ping Zhang, Jia-Yuan Huang, Xiao-Hong Chen, Qian Lei, Feng-Hua Yang, Ren Huang
OBJECTIVE: To evaluate the value of high-frequency echocardiography in assessing cardiac structure and function in a mouse model of myocardial infarction. METHODS: Twenty-five C57BL/6 mice were randomly divided into sham-operated group (n=10) and myocardial infarction model group (n=15) established by ligation of the left anterior descending artery. The cardiac structure, regional wall motion and cardiac function of mice were examined with pulsed wave Doppler (PWD), tissue Doppler imaging (TDI), EKV and M-mode echocardiography 3 days before and at 1 week after the operation...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28801075/doppler-assessment-of-diastolic-function-reflect-the-severity-of-injury-in-rats-with-chronic-heart-failure
#6
Pablo Sanchez, Jordan J Lancaster, Kyle Weigand, Saffie-Alrahman Ezz-Eldin Mohran, Steven Goldman, Elizabeth Juneman
OBJECTIVE: For chronic heart failure (CHF), more emphasis has been placed on evaluation of systolic as opposed to diastolic function. Within the study of diastology, measurements of left ventricular (LV) longitudinal myocardial relaxation have the most validation. Anterior wall radial myocardial tissue relaxation velocities along with mitral valve inflow (MVI) patterns are applicable diastolic parameters in the differentiation between moderate and severe disease in the ischemic rat model of CHF...
August 8, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28800207/optically-derived-metabolic-and-hemodynamic-parameters-predict-hippocampal-neurogenesis-in-the-btbr-mouse-model-of-autism
#7
David Abookasis, Danit Lerman, Hava Roth, Mati Tfilin, Gadi Turgeman
In the present study, we made use of dual-wavelength laser speckle imaging (DW-LSI) to assess cerebral blood flow in the BTBR genetic mouse model of Autism Spectrum Disorder, as well as control (C57Bl/6J) mice. Since the deficits in social behavior demonstrated by BTBR mice are attributed to changes in neural tissue structure and function, we postulated that these changes can be detected optically using DW-LSI. BTBR mice demonstrated reductions in both cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO2 ), as suggested by studies using conventional neuroimaging technologies to reflect impaired neuronal activation and cognitive function...
August 11, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28796040/primary-malignant-mesenchymoma-of-bladder-case-report-and-review-of-the-literature
#8
Zecheng Yang, Xiaodong Yang, Xianqi Lu, Lijian Gao, Gang Li, Xuefeng Zhang
RATIONALE: Malignant mesenchymoma (MM) is defined as a heterogeneous malignant soft tissue tumor that consists of 2 or more distinctly different mesenchymal components in addition to fibrosarcomatous elements. Bladder MM was rarely reported in the literature and there are only 5 cases of primary bladder MM documented in English literature to date. PATIENT CONCERNS: A 58-year-old male complained of difficulty in urination and intermittent gross hematuria for 3 months...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28795324/the-fgf23-klotho-axis-and-cardiac-tissue-doppler-imaging-in-pediatric-chronic-kidney-disease-a-prospective-cohort-study
#9
Ylva Tranæus Lindblad, Hannes Olauson, Georgios Vavilis, Ulf Hammar, Maria Herthelius, Jonas Axelsson, Peter Bárány
BACKGROUND: Chronic kidney disease-associated mineral bone disorder (CKD-MBD) is common in pediatric kidney disease patients and a risk factor for future cardiovascular disease (CVD). Fibroblast growth factor-23 (FGF23) and Klotho are novel key players in CKD-MBD, and has been suggested to be involved in the development of CVD. METHODS: This prospective cohort study included 74 pediatric patients; 31 with CKD (age range 0.8-18.8 years, glomerular filtration rate (GFR) range 9-68 mL/min/1...
August 9, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28792613/peripheral-perfusion-and-oxygenation-in-areas-of-risk-of-skin-integrity-impairment-exposed-to-pressure-patterns-a-phase-i-trial-poter-study
#10
Silvia Garcia-Mayor, Juan Carlos Morilla-Herrera, Inmaculada Lupiáñez-Pérez, Shakira Kaknani Uttumchandani, Álvaro Leon Campos, Marta Aranda-Gallardo, Ana Belén Moya-Suárez, José Miguel Morales-Asencio
AIM: To analyse the changes in peripheral oxygenation and microvascular flow in tissues subjected to different pressure regimes in healthy subjects and in hospitalised patients. BACKGROUND: The presence of pressure ulcers in hospitalised patients is a common complication that has a negative impact on health and often prolongs hospital stay and increases health care costs. DESIGN: Experimental non-controlled, non-randomised study in two phases: preclinical and clinical...
August 9, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28791883/dermatofibroma-sonographic-findings-and-pathologic-correlation
#11
Kyu Yeoun Won, So Young Park, Wook Jin, Bark-Lynn Lew
Background Ultrasound has been increasingly used for the evaluation of superficial soft tissue lesions. Dermatofibroma is one of the most common dermal lesions. Experiences in ultrasound examinations of dermatofibromas have been accumulated. Purpose To evaluate sonographic findings of dermatofibroma and to correlate them with pathologic findings. Material and Methods A total of 18 dermatofibromas in 15 patients were included. Sonographic findings were assessed for location, depth, size, shape, margin, spiculation, echogenicity, internal hyperechoic dots, change in echogenicity of adjacent soft tissue, and vascularity, by two musculoskeletal radiologists in consensus...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28791311/assessment-of-diabetic-cardiomyopathy-by-cardiovascular-magnetic-resonance-t1-mapping-correlation-with-left-ventricular-diastolic-dysfunction-and-diabetic-duration
#12
Yongning Shang, Xiaochun Zhang, Weilling Leng, Liu Chen, Xiaotian Lei, Tianjing Zhang, Andreas Greiser, Ziwen Liang, Jian Wang
PURPOSE: To quantify extracellular matrix expansion with the cardiovascular magnetic resonance (CMR) T1 mapping technique and the derived extracellular volume fraction (ECV) in diabetic cardiomyopathy (DbCM) patients and to detect the relationship among ECV, duration of diabetes, and diastolic function. MATERIALS: Thirty-eight patients with diabetic cardiomyopathy (20 males, age 54.6 ± 8.6 years) and thirty-two matched normal controls (15 males, age 51.4 ± 13...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28781117/increased-coronary-tortuosity-is-associated-with-increased-left-ventricular-longitudinal-myocardial-shortening
#13
Andrew C Oehler, Jessica Minnier, Jonathan R Lindner
BACKGROUND: The mechanistic basis for tortuosity of the coronary arteries (TCA) is unclear. The aim of this study was to test the hypothesis that the relative degree of systolic longitudinal shortening of the left ventricle that deforms coaxially oriented coronary arteries is associated with TCA. METHODS: Adult subjects undergoing coronary angiography and comprehensive echocardiography within 3 months were classified dichotomously as with (n = 32) or without (n = 42) TCA defined on the basis of number and severity of coronary angles...
August 3, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28780920/left-ventricular-diastolic-dysfunction-without-left-ventricular-hypertrophy-in-obese-children-and-adolescents-a-tissue-doppler-imaging-and-cardiac-troponin-i-study
#14
Sonia A El Saiedi, Marwa F Mira, Sahar A Sharaf, Maysoun M Al Musaddar, Rania M H El Kaffas, Antoine F AbdelMassih, Ihab H Y Barsoum
BACKGROUND: Obesity increases the risk for various cardiovascular problems. Increase in body mass index is often an independent risk factor for the development of elevated blood pressure and clustering of various cardiovascular risk factors. OBJECTIVE: To determine early markers of left ventricular affection in obese patients before the appearance of left ventricular hypertrophy. METHODS: In this cross-sectional study, we evaluated 42 obese patients and 30 healthy controls...
August 7, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28777054/an-investigation-of-skin-perfusion-in-venous-leg-ulcer-after-exercise
#15
Omar Mutlak, Mohammed Aslam, Nigel J Standfield
INTRODUCTION: A venous leg ulcer (VLU) has a major impact on the quality of life and functional ability of individuals, but no single treatment is yet effective. This study investigates the changes induced by dorsiflexion exercise on skin perfusion in VLU patients to achieve a better understanding of venous ulcer pathophysiology. METHODS: Seventy-eight venous leg ulcer patients were randomised into four groups. The non-exercise groups included a control group (n = 18) and a compression therapy group (n = 20) and the exercise groups included an exercise-only group (n = 20) and a compression and exercise group (n = 20)...
July 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28772277/factors-to-consider-when-deciding-on-the-type-of-free-flap-reconstruction-of-head-and-neck-soft-tissue-defects
#16
Mohammed Thabet Aladimi, Bo Han, Chunjie Li, Hussein Helal, Zhenjie Gao, Longjiang Li
OBJECTIVES: The aim of the study was to evaluate the functional and aesthetic outcomes on donor and recipient sites and to determine the effects of technical factors including flap thickness and vessel diameters measured by ultrasonography as well as the size of the defect and postoperative volume reduction of the flaps measured by magnetic resonance imaging (MRI). METHODS: In patients who had undergone soft tissue reconstructive surgery between March 2013 and March 2016 using 55 anterolateral thigh flaps (ALTFs), 30 radial forearm flaps (RFFs), and 18 latissimus dorsi flaps (LDFs), color Doppler ultrasonography was performed to measure the thickness of the flap at the site of the perforator...
August 4, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28772034/impaired-myocardial-relaxation-with-exercise-determines-peak-aerobic-exercise-capacity-in-heart-failure-with-preserved-ejection-fraction
#17
Cory Trankle, Justin M Canada, Leo Buckley, Salvatore Carbone, Dave Dixon, Ross Arena, Benjamin Van Tassell, Antonio Abbate
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome characterized by impaired exercise capacity due to shortness of breath and/or fatigue. Assessment of diastolic dysfunction at rest and with exercise may provide insight into the pathophysiology of exercise intolerance in HFpEF. AIMS: To measure echocardio-Doppler-derived parameters of diastolic function as they relate to various indices of aerobic exercise capacity in HFpEF...
August 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28770692/effect-of-high-dose-oral-cholecalciferol-on-cardiac-mechanics-in-children-with-chronic-kidney-disease
#18
Murat Deveci, Mehmet Baha Aytaç, Gürkan Altun, Özlem Kayabey, Kadir Babaoğlu
Cardiovascular factors are an important cause of mortality in chronic kidney disease, and vitamin-D deficiency is common in this patient population. Therefore, we aimed to investigate the effect of oral cholecalciferol on cardiac mechanics in children with chronic kidney disease. A total of 41 children with chronic kidney disease - the patient group - and 24 healthy subjects - the control group - free of any underlying cardiac or renal disease with low 25-hydroxyvitamin-D3 levels were evaluated by conventional tissue Doppler imaging and two-dimensional speckle-tracking echocardiography, both at baseline and following Stoss vitamin-D supplementation...
August 3, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28766046/relationship-between-left-ventricular-diastolic-dysfunction-and-very-late-recurrences-after-multiple-procedures-for-atrial-fibrillation-ablation
#19
Naoaki Onishi, Kazuaki Kaitani, Masashi Amano, Sari Imamura, Jiro Sakamoto, Yodo Tamaki, Soichiro Enomoto, Makoto Miyake, Toshihiro Tamura, Hirokazu Kondo, Chisato Izumi, Yoshihisa Nakagawa
Although very late recurrences (VLRs) (first recurrence >12 months after the last catheter ablation) of atrial fibrillation (AF) after multiple catheter ablation procedures are rare, it remains a critical issue. The risk factors for VLRs remain largely unclear. From December 2011 to April 2014, 253 patients underwent an initial catheter ablation. Of the 253 patients, 21 had AF recurrences within 1 year after the last catheter ablation. The study was conducted in the remaining 232 patients. Left ventricular diastolic dysfunction (LVDD) was assessed by echocardiography using composite categories with tissue Doppler imaging and left atrial volume measurements, i...
August 1, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28764222/evaluation-of-myocardial-injury-using-standard-diagnostic-tools-and-tissue-doppler-imaging-in-blunt-trauma-chest
#20
Parshotam Lal Gautam, Neeru Luthra, Manpreet Kaur, Jaspal Singh, Gurpreet Singh Wander, Rohit Tandon, Namrata, Nikhil Gautam
INTRODUCTION: Myocardial contusion is an entity in chest trauma which is difficult to diagnose. Current practice relies more on cardiac-specific biochemical markers and standard echocardiography, but no gold standard test exists. The application of Tissue Doppler imaging is yet unexplored. AIM: The present study was designed to evaluate cardiac injury in patients with blunt trauma chest using conventional trans-thoracic echocardiography parameters and Tissue Doppler imaging...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
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