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https://www.readbyqxmd.com/read/28201527/high-dose-of-antibiotic-colistin-induces-oligomerization-of-molecular-chaperone-hsp90
#1
Shuntaro Togashi, Kyosuke Takahashi, Arisa Tamura, Ikumi Toyota, Shiori Hatakeyama, Atsushi Komatsuda, Ikuru Kudo, Erina Sasaki Kudoh, Tomoya Okamoto, Asami Haga, Asuka Miyamoto, Ewa Grave, Taku Sugawara, Hiroaki Shimizu, Hideaki Itoh
No abstract text is available yet for this article.
February 14, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28196311/an-opportunity-in-difficulty-japan-korea-taiwan-expert-delphi-consensus-on-surgical-difficulty-during-laparoscopic-cholecystectomy
#2
Yukio Iwashita, Taizo Hibi, Tetsuji Ohyama, Goro Honda, Masahiro Yoshida, Fumihiko Miura, Tadahiro Takada, Ho-Seong Han, Tsann-Long Hwang, Satoshi Shinya, Kenji Suzuki, Akiko Umezawa, Yoo-Seok Yoon, In-Seok Choi, Wayne Shih-Wei Huang, Kuo-Hsin Chen, Manabu Watanabe, Yuta Abe, Takeyuki Misawa, Yuichi Nagakawa, Dong-Sup Yoon, Jin-Young Jang, Hee Chul Yu, Keun Soo Ahn, Song Cheol Kim, In Sang Song, Ji Hoon Kim, Sung-Su Yun, Seong Ho Choi, Yi-Yin Jan, Yan-Shen Shan, Chen-Guo Ker, De-Chuan Chan, Cheng-Chung Wu, King-Teh Lee, Naoyuki Toyota, Ryota Higuchi, Yoshiharu Nakamura, Yoshiaki Mizuguchi, Yutaka Takeda, Masahiro Ito, Shinji Norimizu, Shigetoshi Yamada, Naoki Matsumura, Junichi Shindoh, Hiroki Sunagawa, Takeshi Gocho, Hiroshi Hasegawa, Toshiki Rikiyama, Naohiro Sata, Nobuyasu Kano, Seigo Kitano, Hiromi Tokumura, Yuichi Yamashita, Goro Watanabe, Kunitoshi Nakagawa, Taizo Kimura, Tatsuo Yamakawa, Go Wakabayashi, Rintaro Mori, Itaru Endo, Masaru Miyazaki, Masakazu Yamamoto
BACKGROUND: We previously identified 25 intraoperative findings during laparoscopic cholecystectomy (LC) as potential indicators of surgical difficulty per nominal group technique. This study aimed to build a consensus among expert LC surgeons on the impact of each item on surgical difficulty. METHODS: Surgeons from Japan, Korea, and Taiwan (n = 554) participated in a Delphi process and graded the 25 items on a seven-stage scale (range, 0-6). Consensus was defined as (i) the interquartile range (IQR) of overall responses ≤2 and (ii) ≥66% of the responses concentrated within a median ± 1 after stratification by workplace and LC experience level...
February 14, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28179612/ad-hoc-vs-non-ad-hoc-percutaneous-coronary-intervention-strategies-in-patients-with-stable-coronary-artery-disease
#3
Toshiaki Toyota, Takeshi Morimoto, Hiroki Shiomi, Kenji Ando, Koh Ono, Satoshi Shizuta, Takao Kato, Naritatsu Saito, Yutaka Furukawa, Yoshihisa Nakagawa, Minoru Horie, Takeshi Kimura
BACKGROUND: Few studies have evaluated the prevalence and clinical outcomes of ad hoc percutaneous coronary intervention (PCI), performing diagnostic coronary angiography and PCI in the same session, in stable coronary artery disease (CAD) patients.Methods and Results:From the CREDO-Kyoto PCI/CABG registry cohort-2, 6,943 patients were analyzed as having stable CAD and undergoing first PCI. Ad hoc PCI and non-ad hoc PCI were performed in 1,722 (24.8%) and 5,221 (75.1%) patients, respectively...
February 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28094947/synthesis-of-2-azulenyltetrathiafulvalenes-by-palladium-catalyzed-direct-arylation-of-2-chloroazulenes-with-tetrathiafulvalene-and-their-optical-and-electrochemical-properties
#4
Taku Shoji, Takanori Araki, Shuhei Sugiyama, Akira Ohta, Ryuta Sekiguchi, Shunji Ito, Tetsuo Okujima, Kozo Toyota
Tetrathiafulvalene (TTF) derivatives with 2-azulenyl substituents 5-11 were prepared by the palladium-catalyzed direct arylation reaction of 2-chloroazulenes with TTF in good yield. Photophysical properties of these compounds were investigated by UV-vis spectroscopy and theoretical calculations. Redox behavior of the novel azulene-substituted TTFs was examined by using cyclic voltammetry and differential pulse voltammetry, which revealed their multistep electrochemical oxidation and/or reduction properties...
January 26, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28076383/time-varying-transition-probability-matrix-estimation-and-its-application-to-brand-share-analysis
#5
Tomoaki Chiba, Hideitsu Hino, Shotaro Akaho, Noboru Murata
In a product market or stock market, different products or stocks compete for the same consumers or purchasers. We propose a method to estimate the time-varying transition matrix of the product share using a multivariate time series of the product share. The method is based on the assumption that each of the observed time series of shares is a stationary distribution of the underlying Markov processes characterized by transition probability matrices. We estimate transition probability matrices for every observation under natural assumptions...
2017: PloS One
https://www.readbyqxmd.com/read/28073605/comprehensive-association-analysis-of-27-genes-from-the-gabaergic-system-in-japanese-individuals-affected-with-schizophrenia
#6
Shabeesh Balan, Kazuo Yamada, Yoshimi Iwayama, Takanori Hashimoto, Tomoko Toyota, Chie Shimamoto, Motoko Maekawa, Shu Takagai, Tomoyasu Wakuda, Yosuke Kameno, Daisuke Kurita, Kohei Yamada, Mitsuru Kikuchi, Tasuku Hashimoto, Nobuhisa Kanahara, Takeo Yoshikawa
Involvement of the gamma-aminobutyric acid (GABA)-ergic system in schizophrenia pathogenesis through disrupted neurodevelopment has been highlighted in numerous studies. However, the function of common genetic variants of this system in determining schizophrenia risk is unknown. We therefore tested the association of 375 tagged SNPs in genes derived from the GABAergic system, such as GABAA receptor subunit genes, and GABA related genes (glutamate decarboxylase genes, GABAergic-marker gene, genes involved in GABA receptor trafficking and scaffolding) in Japanese schizophrenia case-control samples (n=2926; 1415 cases and 1511 controls)...
January 7, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28057284/very-late-scaffold-thrombosis-of-bioresorbable-vascular-scaffold-systematic-review-and%C3%A2-a%C3%A2-meta-analysis
#7
Toshiaki Toyota, Takeshi Morimoto, Hiroki Shiomi, Yusuke Yoshikawa, Hidenori Yaku, Yugo Yamashita, Takeshi Kimura
OBJECTIVES: This study sought to compare the 2-year outcomes between bioresorbable vascular scaffold (BVS) and everolimus-eluting metallic drug-eluting stent (EES). BACKGROUND: The occurrence of very late stent/scaffold thrombosis (VLST) of BVS beyond 1 year after implantation is an increasing concern. METHODS: We conducted a meta-analysis of 24 studies (BVS: n = 2,567 and EES: n = 19,806) reporting the 2-year outcomes of BVS and/or EES to compare the risk of BVS versus EES for stent/scaffold thrombosis (ST) and target lesion failure (TLF) in 7 comparative studies (3 randomized and 4 observational), and to estimate the pooled incidence rates of ST and TLF including additional 17 single-arm studies...
January 9, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28054279/successful-resection-of-liver-metastasis-detected-by-exacerbation-of-skin-symptom-in-a-patient-with-dermatomyositis-accompanied-by-rectal-cancer-a-case-report-and-literature-review
#8
Kosuke Ono, Manabu Shimomura, Kazuhiro Toyota, Atsushi Kagimoto, Naofumi Tsukiyama, Masayuki Shishida, Koichi Oishi, Kazuaki Miyamoto, Satoshi Shibata, Masahiro Ikeda, Seiji Sadamoto, Tadateru Takahashi
BACKGROUND: Dermatomyositis (DM) is a rare syndrome that belongs to the group of idiopathic inflammatory myopathies. The association between DM and malignancy is well recognized, and the severity of DM symptoms has been linked to the progression of metastatic disease. CASE PRESENTATION: We report the case of a 42-year-old man that was diagnosed with dermatomyositis (DM) and rectal cancer. Proctectomy was performed, and DM symptoms were resolved postoperatively. One year and 9 months after the surgery, liver metastasis occurred accompanied by the exacerbation of DM symptom...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28042183/integrated-anaerobic-aerobic-biodegradation-of-multiple-contaminants-including-chlorinated-ethylenes-benzene-toluene-and-dichloromethane
#9
Miho Yoshikawa, Ming Zhang, Koki Toyota
Complete bioremediation of soils containing multiple volatile organic compounds (VOCs) remains a challenge. To explore the possibility of complete bioremediation through integrated anaerobic-aerobic biodegradation, laboratory feasibility tests followed by alternate anaerobic-aerobic and aerobic-anaerobic biodegradation tests were performed. Chlorinated ethylenes, including tetrachloroethylene (PCE), trichloroethylene (TCE), cis-dichloroethylene (cis-DCE), and vinyl chloride (VC), and dichloromethane (DCM) were used for anaerobic biodegradation, whereas benzene, toluene, and DCM were used for aerobic biodegradation tests...
2017: Water, Air, and Soil Pollution
https://www.readbyqxmd.com/read/28026137/the-right-way-is-not-always-popular-comparison-of-surgeons-perceptions-during-laparoscopic-cholecystectomy-for-acute-cholecystitis-among-experts-from-japan-korea-and-taiwan
#10
Taizo Hibi, Yukio Iwashita, Tetsuji Ohyama, Goro Honda, Masahiro Yoshida, Tadahiro Takada, Ho-Seong Han, Tsann-Long Hwang, Satoshi Shinya, Kenji Suzuki, Akiko Umezawa, Yoo-Seok Yoon, In-Seok Choi, Wayne Shih-Wei Huang, Kuo-Hsin Chen, Fumihiko Miura, Manabu Watanabe, Yuta Abe, Takeyuki Misawa, Yuichi Nagakawa, Dong-Sup Yoon, Jin-Young Jang, Hee Chul Yu, Keun Soo Ahn, Song Cheol Kim, In Sang Song, Ji Hoon Kim, Sung Su Yun, Seong Ho Choi, Yi-Yin Jan, Shyr-Ming Sheen-Chen, Yan-Shen Shan, Chen-Guo Ker, De-Chuan Chan, Cheng-Chung Wu, Naoyuki Toyota, Ryota Higuchi, Yoshiharu Nakamura, Yoshiaki Mizuguchi, Yutaka Takeda, Masahiro Ito, Shinji Norimizu, Shigetoshi Yamada, Naoki Matsumura, Junichi Shindoh, Hiroki Sunagawa, Takeshi Gocho, Hiroshi Hasegawa, Toshiki Rikiyama, Naohiro Sata, Nobuyasu Kano, Seigo Kitano, Hiromi Tokumura, Yuichi Yamashita, Goro Watanabe, Kunitoshi Nakagawa, Taizo Kimura, Tatsuo Yamakawa, Go Wakabayashi, Itaru Endo, Masaru Miyazaki, Masakazu Yamamoto
BACKGROUND: Generally, surgeons' perceptions of surgical safety are based on experience and institutional policy. Our recent pilot survey demonstrated that the acceptable duration of surgery and criteria for open conversion during laparoscopic cholecystectomy (LC) vary among workplaces. METHODS: A web-based survey was distributed to 554 expert LC surgeons in Japan, Korea, and Taiwan. The questionnaire covered LC experience, safety measures and recognition of landmarks, decision-making regarding conversion to open/partial cholecystectomy and the implications of this decision...
December 26, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27973798/quasi-restricted-orbital-treatment-for-the-density-functional-theory-calculations-of-the-spin-orbit-term-of-zero-field-splitting-tensors
#11
Kenji Sugisaki, Kazuo Toyota, Kazunobu Sato, Daisuke Shiomi, Takeji Takui
A quasi-restricted orbital (QRO) approach for the calculation of the spin-orbit term of zero-field splitting tensors (D(SO) tensors) by means of density functional theory (DFT) importantly features in the fact that it is free from spin contamination problems because it uses spin eigenfunctions for the zeroth order wave functions. In 2011, however, Schmitt and co-workers pointed out that in the originally proposed QRO working equation some possible excitations were not included in their sum-over-states procedure, which causes spurious D(SO) contributions from closed-shell subsystems located far from the magnetic molecule under study...
December 15, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27966960/numerical-estimation-of-the-pseudo-jahn-teller-effect-using-nonadiabatic-coupling-integrals-in-monocyclic-and-bicyclic-conjugated-molecules
#12
Shiro Koseki, Azumao Toyota, Takashi Muramatsu, Toshio Asada, Nikita Matsunaga
The pseudo-Jahn-Teller (pJT) effect in monocyclic and bicyclic conjugated molecules was investigated by using the state-averaged multiconfiguration self-consistent field (MCSCF) method, together with the 6-31G(d,p) basis sets. Following the perturbation theory, the force constant along a normal mode Q is given by the sum of the classical force constant and the vibronic contribution (VC) resulting from the interaction of the ground state with excited states. The latter is given as the sum of individual contributions arising from vibronic interactions between the ground state and excited states...
December 29, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27965197/protein-kinase-c-is-involved-with-upstream-signaling-of-methyl-farnesoate-for-photoperiod-dependent-sex-determination-in-the-water-flea-daphnia-pulex
#13
Kenji Toyota, Tomomi Sato, Norihisa Tatarazako, Taisen Iguchi
Sex determination of Daphnia pulex is decided by environmental conditions. We established a suitable experimental system for this study using D. pulex WTN6 strain, in which the sex of the offspring can be controlled by photoperiod. Long-day conditions induced females and short-day conditions induced males. Using this system, we previously found that methy farnesoate (MF), which is a putative innate juvenile hormone molecule in daphnids, is necessary for male sex determination and that protein kinase C (PKC) is a candidate factor of male sex determiner...
February 15, 2017: Biology Open
https://www.readbyqxmd.com/read/27927931/myoclonia-continua-in-primary-cns-natural-killer-t-cell-lymphoma-nasal-type
#14
Tomoko Toyota, Yusuke Sennari, Kazumasa Okada, Ai Kawahara, Junichi Tsukada, Shohei Shimajiri, Hiroaki Adachi
No abstract text is available yet for this article.
December 7, 2016: Neurology
https://www.readbyqxmd.com/read/27920498/feasibility-of-sequential-adjuvant-chemotherapy-with-a-3-month-oxaliplatin-based-regimen-followed-by-3-months-of-capecitabine-in-patients-with-stage-iii-and-high-risk-stage-ii-colorectal-cancer-jswog-c2-study
#15
Atsushi Tsuruta, Kazuki Yamashita, Hiroaki Tanioka, Akihito Tsuji, Michio Inukai, Toshiki Yamakawa, Tomoki Yamatsuji, Masanori Yoshimitsu, Kazuhiro Toyota, Taketoshi Yamano, Takeshi Nagasaka, Masazumi Okajima
BACKGROUND: Six months of oxaliplatin-based chemotherapy is the standard adjuvant chemotherapy for completely resected stage III colorectal cancer (CRC). Also, patients with stage II CRC who are considered to be at high risk of disease recurrence often receive the same adjuvant chemotherapy treatment. We prospectively investigated the extent and degree of neuropathy suffered by stage III and high-risk stage II resectable CRC patients who underwent sequential approach involving 3 months of an oxaliplatin-based regimen followed by 3 months of capecitabine...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27909011/age-dependent-effects-of-catechol-o-methyltransferase-comt-gene-val158met-polymorphism-on-language-function-in-developing-children
#16
Lisa Sugiura, Tomoko Toyota, Hiroko Matsuba-Kurita, Yoshimi Iwayama, Reiko Mazuka, Takeo Yoshikawa, Hiroko Hagiwara
The genetic basis controlling language development remains elusive. Previous studies of the catechol-O-methyltransferase (COMT) Val(158)Met genotype and cognition have focused on prefrontally guided executive functions involving dopamine. However, COMT may further influence posterior cortical regions implicated in language perception. We investigated whether COMT influences language ability and cortical language processing involving the posterior language regions in 246 children aged 6-10 years. We assessed language ability using a language test and cortical responses recorded during language processing using a word repetition task and functional near-infrared spectroscopy...
November 30, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27888371/protective-effect-of-the-sulfated-agaran-isolated-from-the-red-seaweed-laurencia-aldingensis-against-toxic-effects-of-the-venom-of-the-snake-lachesis-muta
#17
Ana Cláudia Rodrigues da Silva, Luciana Garcia Ferreira, Maria Eugênia Rabello Duarte, Mutue Toyota Fujii, Eladio Flores Sanchez, Miguel Daniel Noseda, André Lopes Fuly
Snakebite is a serious occupational hazard affecting mainly rural populations of tropical and subtropical developing countries. Lachesis muta (Bushmaster) bites are extremely serious but are rarely reported in the literature. Bushmaster envenomings are characterized by intense local pain, edema, neurotoxicity, hypotension, local hemorrhage, and dramatic systemic alterations. Antivenom treatment has regularly been used for more than a century; however, it fails to neutralize local tissue damage and hemorrhage, leading to morbidity or disabilities in victims...
November 25, 2016: Marine Biotechnology
https://www.readbyqxmd.com/read/27885175/cpg-island-methylator-phenotype-high-colorectal-cancers-and-their-prognostic-implications-and-relationships-with-the-serrated-neoplasia-pathway
#18
REVIEW
Ye-Young Rhee, Kyung-Ju Kim, Gyeong Hoon Kang
The concept of a CpG island methylator phenotype (CIMP) was first introduced by Toyota and Issa to describe a subset of colorectal cancers (CRCs) with concurrent hypermethylation of multiple CpG island loci. The concept of CIMP as a molecular carcinogenesis mechanism was consolidated by the identification of the serrated neoplasia pathway, in which CIMP participates in the initiation and progression of serrated adenomas. Distinct clinicopathological and molecular features of CIMP-high (CIMP-H) CRCs have been characterized, including proximal colon location, older age of onset, female preponderance, and frequent associations of high-level microsatellite instability and BRAF mutations...
January 15, 2017: Gut and Liver
https://www.readbyqxmd.com/read/27872899/de-novo-fgf12-mutation-in-2-patients-with-neonatal-onset-epilepsy
#19
Ilaria Guella, Linda Huh, Marna B McKenzie, Eric B Toyota, E Martina Bebin, Michelle L Thompson, Gregory M Cooper, Daniel M Evans, Sarah E Buerki, Shelin Adam, Margot I Van Allen, Tanya N Nelson, Mary B Connolly, Matthew J Farrer, Michelle Demos
OBJECTIVE: We describe 2 additional patients with early-onset epilepsy with a de novo FGF12 mutation. METHODS: Whole-exome sequencing was performed in 2 unrelated patients with early-onset epilepsy and their unaffected parents. Genetic variants were assessed by comparative trio analysis. Clinical evolution, EEG, and neuroimaging are described. The phenotype and response to treatment was reviewed and compared to affected siblings in the original report. RESULTS: We identified the same FGF12 de novo mutation reported previously (c...
December 2016: Neurology. Genetics
https://www.readbyqxmd.com/read/27865193/different-clinical-outcomes-in-patients-with-asymptomatic-severe-aortic-stenosis-according-to-the-stage-classification-does-the-aortic-valve-area-matter
#20
Takeshi Kitai, Tomohiko Taniguchi, Takeshi Morimoto, Toshiaki Toyota, Chisato Izumi, Shuichiro Kaji, Kitae Kim, Naritatsu Saito, Kazuya Nagao, Tsukasa Inada, Eri Minamino-Muta, Takao Kato, Moriaki Inoko, Katsuhisa Ishii, Tadaaki Koyama, Ryuzo Sakata, Yutaka Furukawa, Takeshi Kimura
BACKGROUND: The ACC/AHA guidelines introduced a new classification of severe aortic stenosis (AS) mainly based on maximum jet velocity (Vmax) and mean pressure gradient (mPG), but not on aortic valve area (AVA). However, prognostic value of this new classification has not yet been fully evaluated. METHODS AND RESULTS: We studied 1512 patients with asymptomatic severe AS enrolled in the CURRENT AS registry in whom surgery was not initially planned. Patients were divided into 2 groups: Group 1 (N=122) comprised patients who met the recommendation for surgery; high-gradient (HG)-AS (Vmax≥4...
February 1, 2017: International Journal of Cardiology
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