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https://www.readbyqxmd.com/read/29782071/evaluation-of-idiopathic-olfactory-loss-with-chemosensory-event-related-potentials-and-magnetic-resonance-imaging
#1
Jia Liu, Jayant M Pinto, Ling Yang, Linyin Yao, Xutao Miao, Yongxiang Wei
BACKGROUND: Idiopathic olfactory loss (IOL) accounts for a sizable fraction of olfactory dysfunction, but very little is known about its etiology and electrophysiological changes in the olfactory pathway. METHODS: We analyzed the physiology of IOL using chemosensory event-related potentials (ERPs) (olfactory and trigeminal: oERP and tERP) and olfactory pathway magnetic resonance imaging (MRI) measured in adult patients with IOL and healthy controls. Subjective olfactory function was measured by Toyota and Takagi (T&T) olfactometry and Sniffin' Sticks (SS)...
May 21, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29772367/patterns-of-clinical-utilization-of-stereotactic-laser-ablation-sla-an-analysis-of-the-multi-center-prospective-registry
#2
Robert C Rennert, Usman Khan, Stephen B Tatter, Melvin Field, Brian Toyota, Peter E Fecci, Kevin Judy, Alireza M Mohammadi, Patrick Landazuri, Andrew Sloan, Eric Leuthardt, Clark C Chen
BACKGROUND: Stereotactic laser ablation (SLA), also termed laser interstitial thermal therapy (LITT), is a minimally invasive procedure that is increasingly utilized in neurosurgery. We wished to examine how/if SLA is changing the landscape of treatment options for neurosurgical patients. METHODS: Patients undergoing stereotactic laser ablation were prospectively enrolled in the Laser Ablation of Abnormal Neurological Tissue (LAANTERN) registry. Data from the first 100 enrolled patients are presented here...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29693399/experimental-investigation-of-the-self-propelled-motion-of-a-sodium-oleate-tablet-and-boat-at-an-oil-water-interface
#3
Yasuhito Watahiki, Tomonori Nomoto, Luca Chiari, Taro Toyota, Masanori Fujinami
The self-propelled behavior of macroscopic inanimate objects at surfaces and interfaces are ubiquitous phenomena of fundamental interest in interface science. However, given the existence of a large variety of systems with their own inherent chemical properties, the kinematics of the self-propelled motion and the dynamics of the forces driving these systems often remain largely unknown. Here, we experimentally investigated the spontaneous motion of a sodium oleate tablet at a water-nitrobenzene interface, under non-equilibrium and global isothermal conditions, through measurements of the interfacial tension with the non-invasive, quasi elastic laser scattering method...
April 25, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29688875/decreased-serum-pyridoxal-levels-in-schizophrenia-meta-analysis-and-mendelian-randomization-analysis
#4
Yukiko Tomioka, Shusuke Numata, Makoto Kinoshita, Hidehiro Umehara, Shin-Ya Watanabe, Masahito Nakataki, Yoshimi Iwayama, Tomoko Toyota, Masashi Ikeda, Hidenaga Yamamori, Shinji Shimodera, Atsushi Tajima, Ryota Hashimoto, Nakao Iwata, Takeo Yoshikawa, Tetsuro Ohmori
BACKGROUND: Alterations in one-carbon metabolism have been associated with schizophrenia, and vitamin B6 is one of the key components in this pathway. METHODS: We first conducted a case-control study of serum pyridoxal levels and schizophrenia in a large Japanese cohort ( n = 1276). Subsequently, we conducted a meta-analysis of association studies ( n = 2125). Second, we investigated whether rs4654748, which was identified in a genome-wide association study as a vitamin B6-related single nucleotide polymorphism, was genetically implicated in patients with schizophrenia in the Japanese population ( n = 10 689)...
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29667411/synthesis-and-electronic-properties-of-length-defined-9-10-anthrylene-butadiynylene-oligomers
#5
Maiko Nagaoka, Eiji Tsurumaki, Mai Nishiuchi, Tetsuo Iwanaga, Shinji Toyota
Linear π-conjugated oligomers consisting of anthracene and diacetylene units were readily synthesized by a one-pot process that involved desilylation and oxidative coupling from appropriate building units. We were able to isolate length-defined oligomers ranging from 2-mer to 6-mer as stable and soluble solids having characteristic colors. X-ray analysis and DFT calculations revealed that these oligomers had linear structures and coplanar conformations. The bathochromic shifts in the UV-vis spectra suggested that the π-conjugation was extended with elongation of the linear chain...
April 18, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29666959/carney-complex-a-case-with-thyroid-follicular-adenoma-without-a-prkar1a-mutation
#6
Shinji Hattori, Yukou Yamane, Ryoichi Shimomura, Yuki Uchida, Nobuhiko Toyota, Yoshio Miura, Setsujyo Shiota, Yoshitsugu Tajima
BACKGROUND: Carney complex (CNC) is a very rare disease. Although thyroid lesions are included in the diagnostic criteria for CNC, they are an infrequent occurrence. CASE PRESENTATION: The patient was a 69-year-old woman who had undergone the removal of a left atrial myxoma 10 years earlier, at the age of 59. At the time of the operation, thyroid ultrasonography (US) revealed multiple hypoechoic nodules. Thyroid scintigraphy revealed an increased uptake of 99m Tc in these lesions, which was consistent with toxic multinodular goiter, and she was diagnosed with CNC...
April 17, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29605245/successful-catheter-treatment-using-pre-operative-3d-organ-model-simulation-for-atrial-septal-defect-with-dextrocardia-and-interrupted-inferior-vena-cava-to-the-superior-vena-cava
#7
Masao Imai, Masaharu Yoshida, Toshiaki Toyota, Hiroki Shiomi, Satoshi Shizuta, Naritatsu Saito, Takeshi Kimura
No abstract text is available yet for this article.
March 23, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29584475/occupant-kinematics-of-the-hybrid-iii-thor-m-and-postmortem-human-surrogates-under-various-restraint-conditions-in-full-scale-frontal-sled-tests
#8
Devon L Albert, Stephanie M Beeman, Andrew R Kemper
OBJECTIVE: The objective of this research was to compare the occupant kinematics of the Hybrid III (HIII), THOR-M, and postmortem human surrogates (PMHS) during full-scale frontal sled tests under 3 safety restraint conditions: knee bolster (KB), knee bolster and steering wheel airbag (KB/SWAB), and knee bolster airbag and steering wheel airbag (KBAB/SWAB). METHODS: A total of 20 frontal sled tests were performed with at least 2 tests performed per restraint condition per surrogate...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29582896/cognitive-dysfunction-in-urban-community-dwelling-prefrail-older-subjects
#9
H Umegaki, T Makino, H Shimada, T Hayashi, X Wu Cheng, M Kuzuya
OBJECTIVES: A number of studies have reported that frailty is cross-sectionally associated with cognitive decline and is also a risk for future cognitive decline or dementia; however, there have been only a few studies that focus on the association between prefrailty and cognitive dysfunction. In the current study, we investigated the association between prefrailty and cognition. DESIGN: A cross-sectional study of the data obtained at registration in a randomized control trial...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29575254/a-phase-ii-study-of-adjuvant-chemotherapy-with-paclitaxel-and-nedaplatin-for-uterine-cervical-cancer-with-lymph-node-metastasis
#10
Munetaka Takekuma, Mototsugu Shimokawa, Shin Nishio, Hideo Omi, Tsutomu Tabata, Yuji Takei, Kaei Nasu, Yoshiyuki Takahashi, Shinji Toyota, Yoshikazu Ichikawa, Atsushi Arakawa, Fuminori Ito, Hiroshi Tsubamoto, Taisuke Mori, Yasuyuki Hirashima, Kimihiko Ito
The purpose of this phase II trial was to assess the efficacy and toxicity of paclitaxel and nedaplatin (TN) as the initial postoperative adjuvant chemotherapy for uterine cervical cancer with lymph node metastases (LNM). Patients with FIGO stage IB1-IIA2 squamous cell carcinoma of the uterine cervix were enrolled. Histological confirmation of LNM was mandatory. Intravenous paclitaxel at 175 mg/m2 and nedaplatin at 80 mg/m2 were administered every 28-day cycle, of which there were five cycles after radical hysterectomy...
March 25, 2018: Cancer Science
https://www.readbyqxmd.com/read/29500489/potent-viral-suppression-and-improvements-in-alpha-fetoprotein-and-measures-of-fibrosis-in-japanese-patients-receiving-a-daclatasvir-asunaprevir-beclabuvir-fixed-dose-combination-for-the-treatment-of-hcv-genotype-1-infection
#11
Norio Akuta, Joji Toyota, Yoshiyasu Karino, Fusao Ikeda, Akio Ido, Katsuaki Tanaka, Koichi Takaguchi, Atsushi Naganuma, Eiichi Tomita, Kazuaki Chayama, Shigetoshi Fujiyama, Yukiko Inada, Hitoshi Yoshiji, Hideaki Watanabe, Hiroki Ishikawa, Fiona McPhee, Stephanie Noviello, Hiromitsu Kumada
BACKGROUND: In the UNITY-3 study, 96% sustained virologic response (SVR12) rate was observed in Japanese patients with hepatitis C virus (HCV) genotype (GT)-1 infection treated for 12 weeks with fixed-dose daclatasvir, asunaprevir, and beclabuvir (DCV-TRIO). As HCV clearance may improve liver outcomes, we assessed hepatic fibrosis and alpha-fetoprotein (AFP), a hepatocellular carcinoma risk marker, pre- and post-treatment in UNITY-3. METHODS: Treatment-naive or interferon-experienced UNITY-3 patients with HCV GT-1 who received twice-daily DCV-TRIO were assessed for fibrosis [FibroTest; FibroScan; fibrosis-4 index (FIB-4), aspartate-aminotransferase-to-platelet-ratio index] and AFP at baseline and Weeks 4 (FIB-4 only), 12 or 24 post-treatment...
March 2, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29492748/cytoplasmic-hu-antigen-r-hur-expression-is-associated-with-poor-survival-in-patients-with-surgically-resected-cholangiocarcinoma-treated-with-adjuvant-gemcitabine-based-chemotherapy
#12
Kazuhiro Toyota, Yoshiaki Murakami, Naru Kondo, Kenichiro Uemura, Naoya Nakagawa, Shinya Takahashi, Taijiro Sueda
BACKGROUND: Hu-antigen R (HuR) is an RNA-binding protein that regulates the stability, translation, and nucleus-to-cytoplasm translocation of messenger RNAs (mRNAs). OBJECTIVE: The aim of this study was to investigate the prognostic significance of HuR in cholangiocarcinoma patients who received adjuvant gemcitabine-based chemotherapy (AGC) after surgical resection. METHODS: Nuclear and cytoplasmic HuR expression was investigated immunohistochemically in 131 patients with resected cholangiocarcinoma, including 91 patients administered AGC and 40 patients who did not receive adjuvant chemotherapy...
May 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29491204/morphological-control-of-microtubule-encapsulating-giant-vesicles-by-changing-hydrostatic-pressure
#13
Kingo Takiguchi, Masahito Hayashi, Yuki Kazayama, Taro Toyota, Yoshie Harada, Masayoshi Nishiyama
For the development of artificial cell-like machinery, liposomes encapsulating cytoskeletons have drawn much recent attention. However, there has been no report showing isothermally reversible morphological changes of liposomes containing cytoskeletons. We succeeded in reversibly changing the shape of cell-sized giant vesicles by controlling the polymerization/depolymerization state of cytoskeletal microtubules that were encapsulated in the vesicles using pressure changes. The result indicates that it is possible to manipulate artificial cell models composed of molecules such as lipids and proteins...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29488304/objectively-measured-physical-activity-and-cognitive-function-in-urban-dwelling-older-adults
#14
Hiroyuki Umegaki, Taeko Makino, Kazuki Uemura, Hiroyuki Shimada, Xian W Cheng, Masafumi Kuzuya
AIM: Physical activity (PA) and cognition have reportedly been associated with each other. However, it remains to be elucidated what intensities of PA are most strongly associated with cognition. In the current study, we aimed to determine the association between the intensities of objectively measured PA and cognitive function. METHODS: The present study was a cross-sectional analysis of the data obtained at registration in a randomized control trial in Toyota, Japan...
February 28, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29471955/a-case-of-successful-reopening-of-left-main-coronary-artery-occlusion-after-transcatheter-aortic-valve-replacement
#15
Masaharu Yoshida, Naritatsu Saito, Masao Imai, Akira Tsujimura, Kazuhisa Sakamoto, Toshiaki Toyota, Taro Nakatsu, Hirotoshi Watanabe, Tomohiko Taniguchi, Hidenori Yaku, Junichi Tazaki, Hiroki Shiomi, Toshiyuki Mizota, Takao Kato, Kazuhiro Yamazaki, Takeshi Kimura
No abstract text is available yet for this article.
February 26, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29402374/decreased-serum-pyridoxal-levels-in-schizophrenia-meta-analysis-and-mendelian-randomization-analysis
#16
Yukiko Tomioka, Shusuke Numata, Makoto Kinoshita, Hidehiro Umehara, Shin-Ya Watanabe, Masahito Nakataki, Yoshimi Iwayama, Tomoko Toyota, Masashi Ikeda, Hidenaga Yamamori, Shinji Shimodera, Atsushi Tajima, Ryota Hashimoto, Nakao Iwata, Takeo Yoshikawa, Tetsuro Ohmori
BACKGROUND: Alterations in one-carbon metabolism have been associated with schizophrenia, and vitamin B6 is one of the key components in this pathway. METHODS: We first conducted a case-control study of serum pyridoxal levels and schizophrenia in a large Japanese cohort ( n = 1276). Subsequently, we conducted a meta-analysis of association studies ( n = 2125). Second, we investigated whether rs4654748, which was identified in a genome-wide association study as a vitamin B6-related single nucleotide polymorphism, was genetically implicated in patients with schizophrenia in the Japanese population ( n = 10 689)...
February 2, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29394665/-subtotal-esophagectomy-for-mediastinal-lymph-node-oligo-recurrence-of-alk-positive-lung-adenocarcinoma-a-case-report
#17
Satoshi Tetsumoto, Kaoru Okada, Hideki Nagata, Shigenori Toyota, Satoshi Tanaka, Toshie Niki, Naotoshi Tsuruta, Naozumi Higaki, Takashi Niju, Yoshio Oka, Riichiro Nezu, Toshiyuki Ikeda
The patient was a 54-year-old woman with anaplastic lymphoma kinase-positive stage III B lung cancer. She received 4 courses of carboplatin(CBDCA)plus paclitaxel(PTX)plus bevacizumab(Bev)chemotherapy and crizotinib. Chemotherapy reduced the size of the primary site and mediastinal lymphadenopathy; however, the right supraclavicular and subcarinal lymph nodes were enlarged again during crizotinib treatment. Because it was an oligo-recurrence, we performed radiotherapy for these lymph nodes and changed systemic chemotherapy to alectinib...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29356192/how-much-of-toyota-s-philosophy-is-embedded-in-health-care-at-the-organisational-level-a-review
#18
Alain Antierens, Dimitri Beeckman, Sofie Verhaeghe, Dries Myny, Ann Van Hecke
AIMS: Identify which of Toyota's principles are reported in health care institutions at the organisational level and to identify the type of reported outcomes related to the effectiveness of lean production reported in these studies. BACKGROUND: No scientific research has been conducted to determine which of Toyota's principles are embedded in health care systems. This knowledge is needed to perform targeted adjustments in health care. EVALUATION: Sixty studies were identified for the final analysis...
January 22, 2018: Journal of Nursing Management
https://www.readbyqxmd.com/read/29346770/integrative-analyses-of-de-novo-mutations-provide-deeper-biological-insights-into-autism-spectrum-disorder
#19
Atsushi Takata, Noriko Miyake, Yoshinori Tsurusaki, Ryoko Fukai, Satoko Miyatake, Eriko Koshimizu, Itaru Kushima, Takashi Okada, Mako Morikawa, Yota Uno, Kanako Ishizuka, Kazuhiko Nakamura, Masatsugu Tsujii, Takeo Yoshikawa, Tomoko Toyota, Nobuhiko Okamoto, Yoko Hiraki, Ryota Hashimoto, Yuka Yasuda, Shinji Saitoh, Kei Ohashi, Yasunari Sakai, Shouichi Ohga, Toshiro Hara, Mitsuhiro Kato, Kazuyuki Nakamura, Aiko Ito, Chizuru Seiwa, Emi Shirahata, Hitoshi Osaka, Ayumi Matsumoto, Saoko Takeshita, Jun Tohyama, Tomoko Saikusa, Toyojiro Matsuishi, Takumi Nakamura, Takashi Tsuboi, Tadafumi Kato, Toshifumi Suzuki, Hirotomo Saitsu, Mitsuko Nakashima, Takeshi Mizuguchi, Fumiaki Tanaka, Norio Mori, Norio Ozaki, Naomichi Matsumoto
Recent studies have established important roles of de novo mutations (DNMs) in autism spectrum disorders (ASDs). Here, we analyze DNMs in 262 ASD probands of Japanese origin and confirm the "de novo paradigm" of ASDs across ethnicities. Based on this consistency, we combine the lists of damaging DNMs in our and published ASD cohorts (total number of trios, 4,244) and perform integrative bioinformatics analyses. Besides replicating the findings of previous studies, our analyses highlight ATP-binding genes and fetal cerebellar/striatal circuits...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29311474/enantioselective-monoclonal-antibodies-for-detecting-ketamine-to-crack-down-on-illicit-use
#20
Izumi Morita, Hiroyuki Oyama, Yui Kanda, Mayumi Yasuo, Aya Ito, Masahiro Toyota, Yoshinori Hayashi, Takeshi Yokoyama, Norihiro Kobayashi
Ketamine (KT) is a chiral anesthetic agent, (R)- and (S)-enantiomers of which differ in their pharmacological properties. KT has become one of the most commonly used illicit drugs in the world, thus, rapid and feasible on-site testing is required to crack down on the illicit use. Although immunochemical approach with specific antibodies is promising for this purpose, in practice anti-KT antibodies are difficult to obtain. We here disclose generation of monoclonal antibodies against KT. Mice were immunized with either (a) commercially-available or (b) in-house-prepared KT-albumin conjugates...
2018: Biological & Pharmaceutical Bulletin
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