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https://www.readbyqxmd.com/read/28811059/an-infant-with-epilepsy-and-recurrent-hemiplegia-due-to-compound-heterozygous-variants-in-atp1a2
#1
Colin Wilbur, Sarah E Buerki, Ilaria Guella, Eric B Toyota, Daniel M Evans, Marna B McKenzie, Anita Datta, Aspasia Michoulas, Shelin Adam, Margot I Van Allen, Tanya N Nelson, Matthew J Farrer, Mary B Connolly, Michelle Demos
BACKGROUND: Pathogenic heterozygous variants in the ATP1A2 gene have most commonly been associated with familial hemiplegic migraine. However, a wide spectrum of phenotypes that include alternating hemiplegia of childhood and epilepsy have been described. PATIENT DESCRIPTION: We describe a boy who presented at age three months with a complex phenotype that included epilepsy, nonepileptic paroxysmal events, and recurrent hemiplegia. Magnetic resonance imaging demonstrated unilateral cortical edema during a severe episode of hemiplegia that was followed by a persistent mild hemiparesis...
June 8, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28783933/improvement-of-visuo-spatial-function-assessed-by-raven-s-colored-progressive-matrices-in-dementia-with-lewy-bodies-by-donepezil-treatment
#2
Yuta Yoshino, Takaaki Mori, Taku Yoshida, Yasutaka Toyota, Hideaki Shimizu, Jun-Ichi Iga, Shusaku Nishitani, Shu-Ichi Ueno
Objective: Donepezil is used to improve cognitive impairment of dementia with Lewy bodies (DLB). Visuo-spatial dysfunction is a well-known symptom of DLB. Non-verbal Raven's Colored Progressive Matrices (RCPM) were used to assess both visual perception and reasoning ability in DLB subjects treated with donepezil. Methods: Twenty-one DLB patients (mean age, 78.7±4.5 years) were enrolled. RCPM assessment was performed at the time of starting donepezil and within one year after starting donepezil...
August 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28777935/de-novo-mutations-in-ywhag-cause-early-onset-epilepsy
#3
Ilaria Guella, Marna B McKenzie, Daniel M Evans, Sarah E Buerki, Eric B Toyota, Margot I Van Allen, Mohnish Suri, Frances Elmslie, Marleen E H Simon, Koen L I van Gassen, Delphine Héron, Boris Keren, Caroline Nava, Mary B Connolly, Michelle Demos, Matthew J Farrer
Massively parallel sequencing has revealed many de novo mutations in the etiology of developmental and epileptic encephalopathies (EEs), highlighting their genetic heterogeneity. Additional candidate genes have been prioritized in silico by their co-expression in the brain. Here, we evaluate rare coding variability in 20 candidates nominated with the use of a reference gene set of 51 established EE-associated genes. Variants within the 20 candidate genes were extracted from exome-sequencing data of 42 subjects with EE and no previous genetic diagnosis...
August 3, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28770675/photoperiodism-of-male-offspring-production-in-the-water-flea-daphnia-pulex
#4
Kenji Toyota, Tomomi Sato, Norihisa Tatarazako, Taisen Iguchi
Photoperiodism is a biological seasonal timing system utilized to regulate development and reproduction in organisms. The freshwater micro-crustacean Daphnia pulex displays environmental sex determination, the precise physiological mechanisms of which are largely unknown due to the lack of an experimental system to induce female or male offspring production by alterations of the rearing environment. We recently found that D. pulex, WTN6 strain, produces female or male offspring in response to long-day or short-day conditions, respectively...
August 2017: Zoological Science
https://www.readbyqxmd.com/read/28765510/the-arabidopsis-lazy1-family-plays-a-key-role-in-gravity-signaling-within-statocytes-and-in-branch-angle-control-of-roots-and-shoots
#5
Masatoshi Taniguchi, Masahiko Furutani, Takeshi Nishimura, Moritaka Nakamura, Toyohito Fushita, Kohta Iijima, Kenichiro Baba, Hirokazu Tanaka, Masatsugu Toyota, Masao Tasaka, Miyo Terao Morita
During gravitropism, the directional signal of gravity is perceived by gravity-sensing cells called statocytes, leading to asymmetric distribution of auxin in the responding organs. To identify the genes involved in gravity signaling in statocytes, we performed transcriptome analyses of statocyte-deficient Arabidopsis thaliana mutants and found two candidates from the LAZY1 family, AtLAZY1/LAZY1-LIKE1 (LZY1) and AtDRO3/AtNGR1/LZY2. We showed that LZY1, LZY2, and a paralog AtDRO1/AtNGR2/LZY3 are redundantly involved in gravitropism of the inflorescence stem, hypocotyl, and root...
August 1, 2017: Plant Cell
https://www.readbyqxmd.com/read/28739245/management-of-mass-casualties-using-doctor-helicopters-and-doctor-cars
#6
Hiromichi Ohsaka, Kouhei Ishikawa, Kazuhiko Omori, Kei Jitsuiki, Toshihiko Yoshizawa, Youichi Yanagawa
At approximately 10 o'clock in September 2015, a minibus carrying 18 people accidentally slid backwards because of a malfunctioning brake system while climbing a steep incline on Togasayama Mountain, colliding with a van (Toyota HiAce wagon) carrying 11 people that was situated behind the minibus. Togasayama Mountain is located 1 hour by car and 10 minutes by helicopter from our hospital. The minibus slid off a roadside cliff at a height of 0.5 m and rolled over after colliding with the van. There were 7 victims with yellow tags and 22 with green tags...
July 2017: Air Medical Journal
https://www.readbyqxmd.com/read/28733994/seasonal-recruitment-and-survival-strategies-of-palisada-cervicornis-comb-nov-ceramiales-rhodophyta-in-coral-reefs
#7
Ligia Collado-Vides, Alain Duran, Elizabeth Armenis, Valéria Cassano, Deron Burkepile, Andrew A Shantz, Laura Palma, Jhoana Díaz-Larrea, Abel Sentíes, Mutue Toyota Fujii
As marine tropical ecosystems deteriorate and lose biodiversity, their communities are shifting to being dominated by a few species, altering ecosystem's functioning and services. Macroalgae are becoming dominant on coral reefs, and are frequently observed outcompeting corals. Turf algal assemblages are the base of energy flow in these systems and one of the most abundant types of macroalgae on coral reefs, but little is known about their biology and diversity. Through molecular and morphological analyses, we identified the turf-forming species Laurencia cervicornis, and by studying seasonal recruitment and the impact of herbivorous fishes on its abundance, we describe its survival strategy...
July 22, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28711819/differentiation-potential-of-synoviocytes-derived-from-joints-with-cranial-cruciate-ligament-rupture-and-medial-patella-luxation-in-dogs
#8
H M Suranji Wijekoon, Kazuhide Toyota, Sangho Kim, Jing Fang, Eugene C Bwalya, Kenji Hosoya, Masahiro Okumura
The objective of this study was to assess the differentiation capability of synoviocytes derived from dogs with inflammatory joint conditions. Cranial cruciate ligament ruptured (CCLr) (n=12) and medial patella luxated (MPL) (n=10) knee joints of the dogs were used to collect the synovial membrane (SM). Synoviocytes were enzymatically released from the SM and analyzed by flow cytometry for specific cellular markers (CD44 and CD90) of mesenchymal stem cells (MSCs), while doing histopathology from another part of SM sections...
July 9, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28674351/azathioprine-intolerance-in-japanese-patients-with-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#9
Michiko Morishita, Haruki Watanabe, Minglu Yan, Sonia Zeggar, Sumie Hiramatsu, Keiji Ohashi, Yoshia Miyawaki, Eri Katsuyama, Takayuki Katsuyama, Mariko Takano Narazaki, Noriko Toyota Tatebe, Katsue Sunahori Watanabe, Tomoko Kawabata, Ken-Ei Sada, Jun Wada
Objective To assess the safety of azathioprine (AZA) in Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Methods We retrospectively enrolled 67 consecutive AAV patients who had initiated AZA treatment from January 2006 to August 2014 at Okayama University Hospital. We evaluated the development of severe adverse events (AEs), AZA discontinuation due to total AEs (severe AEs included) within 1 year, and AZA-associated risk factors. Results The patients' median age was 70 years old...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28661702/maternal-gaze-behaviors-during-latching-on-for-breastfeeding
#10
Keiko Kikuchi, Mari Toyota, Keiko Endo, Yasuka Nakamura, Fumi Atogami, Toyoko Yoshizawa
BACKGROUND: Studies in various fields have demonstrated that experts use specific gaze strategies to achieve better performance. Therefore, we hypothesized that mothers familiar with breastfeeding would use a specific gaze strategy to achieve better latching-on. METHODS: A head-mounted eye tracker was used to record pupil positions from 14 breastfeeding mothers with 1-month-old infants. Eye gazes were analyzed during the latching-on and assessment phases. RESULTS: During the latching-on phase, participants tended to fixate on their breast, the infant's lower face, an intermediate region between the infant's face and the breast, and the region of contact between the infant's mouth and the breast...
June 29, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28614532/patient-concerns-inventory-for-head-and-neck-cancer-brazilian-cultural-adaptation
#11
Ivy Jungerman, Julia Toyota, Neyller Patriota Montoni, Elma Heitmann Mares Azevedo, Renata Ligia Vieira Guedes, Aline Damascena, Derek Lowe, José Guilherme Vartanian, Simon N Rogers, Luiz Paulo Kowalski
Objective: The purpose of this study was to translate, culturally validate and evaluate the Patients Concerns Inventory - Head and Neck (PCI-H&N) in a consecutive series of Brazilian patients. Method: This study included adult patients treated for upper aerodigestive tract (UADT) cancer. The translation and cultural adaptation of the PCI-H&N followed internationally accepted guidelines and included a pretest sample of patients that completed the first Brazilian Portuguese version of the PCI...
April 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28571519/using-lean-manufacturing-principles-to-evaluate-wait-times-for-hiv-positive-patients-in-an-urban-clinic-in-kenya
#12
Aliza Monroe-Wise, Elizabeth Reisner, Kenneth Sherr, David Ojakaa, Lilian Mbau, Paul Kisia, Samuel Muhula, Carey Farquhar
As human immunodeficiency virus (HIV) treatment programs expand in Africa, delivery systems must be strengthened to support patient retention. Clinic characteristics may affect retention, but a relationship between clinic flow and attrition is not established. This project characterized HIV patient experience and flow in an urban Kenyan clinic to understand how these may affect retention. We used Toyota's lean manufacturing principles to guide data collection and analysis. Clinic flow was evaluated using value stream mapping and time and motion techniques...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28569799/femtosecond-response-of-polyatomic-molecules-to-ultra-intense-hard-x-rays
#13
A Rudenko, L Inhester, K Hanasaki, X Li, S J Robatjazi, B Erk, R Boll, K Toyota, Y Hao, O Vendrell, C Bomme, E Savelyev, B Rudek, L Foucar, S H Southworth, C S Lehmann, B Kraessig, T Marchenko, M Simon, K Ueda, K R Ferguson, M Bucher, T Gorkhover, S Carron, R Alonso-Mori, J E Koglin, J Correa, G J Williams, S Boutet, L Young, C Bostedt, S-K Son, R Santra, D Rolles
X-ray free-electron lasers enable the investigation of the structure and dynamics of diverse systems, including atoms, molecules, nanocrystals and single bioparticles, under extreme conditions. Many imaging applications that target biological systems and complex materials use hard X-ray pulses with extremely high peak intensities (exceeding 10(20) watts per square centimetre). However, fundamental investigations have focused mainly on the individual response of atoms and small molecules using soft X-rays with much lower intensities...
June 1, 2017: Nature
https://www.readbyqxmd.com/read/28562629/a-retrospective-observational-study-of-glucocorticoid-induced-diabetes-mellitus-with-iga-nephropathy-treated-with-tonsillectomy-plus-methylprednisolone-pulse-therapy
#14
Yoshia Miyawaki, Takayuki Katsuyama, Ken-Ei Sada, Sumie Hiramatsu, Keiji Ohashi, Michiko Morishita, Eri Katsuyama, Haruki Watanabe, Mariko Takano-Narazaki, Noriko Toyota-Tatebe, Katsue Sunahori-Watanabe, Tomoko Kawabata, Tatsuyuki Inoue, Masaru Kinomura, Hitoshi Sugiyama, Jun Wada
AIMS: To evaluate the incidence of GC-DM among patients with immunoglobulin A nephropathy (IgAN) and to confirm the risk factors for the development of GC-DM. METHODS: The medical records of patients with IgAN newly treated with the protocol of tonsillectomy combined with steroid pulse therapy were reviewed. The primary outcome was the development of GC-DM within the hospitalization period and during one year of follow-up. RESULTS: During hospitalization, 19 of the 95 patients developed GC-DM (20...
2017: PloS One
https://www.readbyqxmd.com/read/28559475/interplay-of-plasma-membrane-and-vacuolar-ion-channels-together-with-bak1-elicits-rapid-cytosolic-calcium-elevations-in-arabidopsis-during-aphid-feeding
#15
Thomas R Vincent, Marieta Avramova, James Canham, Peter Higgins, Natasha Bilkey, Sam T Mugford, Marco Pitino, Masatsugu Toyota, Simon Gilroy, Anthony J Miller, Saskia A Hogenhout, Dale Sanders
A transient rise in cytosolic calcium ion concentration is one of the main signals used by plants in perception of their environment. The role of calcium in the detection of abiotic stress is well documented; however, its role during biotic interactions remains unclear. Here, we use a fluorescent calcium biosensor (GCaMP3) in combination with the green peach aphid (Myzus persicae) as a tool to study Arabidopsis thaliana calcium dynamics in vivo and in real time during a live biotic interaction. We demonstrate rapid and highly localized plant calcium elevations around the feeding sites of M...
June 2017: Plant Cell
https://www.readbyqxmd.com/read/28502179/self-propelled-motion-of-monodisperse-underwater-oil-droplets-formed-by-a-microfluidic-device
#16
Naoko Ueno, Taisuke Banno, Arisa Asami, Yuki Kazayama, Yuya Morimoto, Toshihisa Osaki, Shoji Takeuchi, Hiroyuki Kitahata, Taro Toyota
We evaluated the speed profile of self-propelled underwater oil droplets comprising a hydrophobic aldehyde derivative in terms of their diameter and the surrounding surfactant concentration using a microfluidic device. We found that the speed of the oil droplets is dependent on not only the surfactant concentration but also the droplet size in a certain range of the surfactant concentration. This tendency is interpreted in terms of combination of the oil and surfactant affording spontaneous emulsification in addition to the Marangoni effect...
June 6, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28482045/using-gcamp3-to-study-ca2-signaling-in-nicotiana-species
#17
Thomas A DeFalco, Masatsugu Toyota, Van Phan, Purva Karia, Wolfgang Moeder, Simon Gilroy, Keiko Yoshioka
Ca2+ signaling is a central component of plant biology; however, direct analysis of in vivo Ca2+ levels is experimentally challenging. In recent years the use of genetically-encoded Ca2+ indicators have revolutionized the study of plant Ca2+ signaling, although such studies have been largely restricted to the model plant Arabidopsis. We have developed stable transgenic Nicotiana benthamiana and Nicotiana tabacum lines expressing the single-wavelength fluorescent Ca2+ indicator, GCaMP3. Ca2+ levels in these plants can be imaged in situ using fluorescence microscopy, and these plants can be used to both qualitatively and semi-quantitatively evaluate Ca2+ signals in response to a broad array of abiotic or biotic stimuli, such as cold-shock or pathogen-associated molecular patterns (PAMPs)...
May 8, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28465099/structure-activity-relationships-of-rosiglitazone-for-peroxisome-proliferator-activated-receptor-gamma-transrepression
#18
Yosuke Toyota, Sayaka Nomura, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
Anti-inflammatory effects of peroxisome proliferator-activated receptor gamma (PPRAγ) ligands are thought to be largely due to PPARγ-mediated transrepression. Thus, transrepression-selective PPARγ ligands without agonistic activity or with only partial agonistic activity should exhibit anti-inflammatory properties with reduced side effects. Here, we investigated the structure-activity relationships (SARs) of PPARγ agonist rosiglitazone, focusing on transrepression activity. Alkenic analogs showed slightly more potent transrepression with reduced efficacy of transactivating agonistic activity...
June 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28386227/the-associations-among-insulin-resistance-hyperglycemia-physical-performance-diabetes-mellitus-and-cognitive-function-in-relatively-healthy-older-adults-with-subtle-cognitive-dysfunction
#19
Hiroyuki Umegaki, Taeko Makino, Kazuki Uemura, Hiroyuki Shimada, Takahiro Hayashi, Xian Wu Cheng, Masafumi Kuzuya
Insulin resistance (IR), diabetes mellitus (DM), sarcopenia, and cognitive dysfunction are thought to be mutually associated. We conducted a comprehensive assessment of the relationships among IR, gait speed, hyperglycemia, and DM by cross-sectionally analyzing the baseline data of an interventional study for cognitive preservation with physical exercise (the TOyota Preventional Intervention for Cognitive decline and Sarcopenia [TOPICS]). The participants (n = 444) were relatively healthy older individuals who had mild cognitive impairment without dementia, and 61 of the participants had DM...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28381693/qrs-score-at-presentation-electrocardiogram-is-correlated-with-infarct-size-and-mortality-in-st-segment-elevation-myocardial-infarction-patients-undergoing-primary-percutaneous-coronary-intervention
#20
Hiroki Shiomi, Masami Kosuge, Takeshi Morimoto, Hiroki Watanabe, Tomohiko Taniguchi, Kenji Nakatsuma, Toshiaki Toyota, Erika Yamamoto, Satoshi Shizuta, Tomohisa Tada, Yutaka Furukawa, Yoshihisa Nakagawa, Kenji Ando, Kazushige Kadota, Kazuo Kimura, Takeshi Kimura
BACKGROUND: In ST-segment elevation myocardial infarction (STEMI), QRS score at presentation ECG may reflect the progression of infarction and facilitate prediction of the degree of myocardial salvage achieved by reperfusion therapy.Methods and Results:Admission electrocardiogram (ECG) was studied in 2,607 patients with STEMI undergoing primary percutaneous coronary intervention (PCI) within 24 h of symptom onset. Patients were classified into 3 groups according to QRS score: low (0-3, n=1,227), intermediate (4-7, n=810), and high (≥8, n=570)...
July 25, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
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