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https://www.readbyqxmd.com/read/28817811/downregulation-of-microrna-330-correlates-with-the-radiation-sensitivity-and-prognosis-of-patients-with-brain-metastasis-from-lung-cancer
#1
Li-Peng Jiang, Zhi-Tu Zhu, Yue Zhang, Chun-Yan He
BACKGROUND: The present study sought to explore the role of microRNA-330 (miR-330) in predicting the radiation response and prognosis of patients with brain metastasis (BM) from lung cancer (LC). METHODS: Patients with BM from LC were identified and classified into radiation-sensitive and radiation-resistant groups according to the overall survival rate, local and distant recurrence rate after conventional whole-brain radiation therapy. Quantitative realtime polymerase chain reaction (qRT-PCR) was used to detect miR-330 expression in serum...
August 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28817781/availability-and-variation-of-publicly-reported-prescription-drug-prices
#2
Jeffrey T Kullgren, Joel E Segel, Timothy A Peterson, A Mark Fendrick, Simone Singh
OBJECTIVES: To examine how often retail prices for prescription drugs are available on state public reporting websites, the variability of these reported prices, and zip code characteristics associated with greater price variation. STUDY DESIGN: Searches of state government-operated websites in Michigan, Missouri, New York, and Pennsylvania for retail prices for Advair Diskus (250/50 fluticasone propionate/salmeterol), Lyrica (pregabalin 50 mg), Nasonex (mometasone 50 mcg nasal spray), Spiriva (tiotropium 18 mcg cp-handihaler), Zetia (ezetimibe 10 mg), atorvastatin 20 mg, and metoprolol 50 mg...
July 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28817772/quantifying-elucidating-thermally-enhanced-minority-carrier-diffusion-length-using-radius-controlled-rutile-nanowires
#3
Liming Zhang, Litianqi Sun, Zixuan Guan, Sang Chul Lee, Yingzhou Li, Haitao Dean Deng, Yiyang Li, Nadia Ahlborg, Madhur Boloor, Nicholas A Melosh, William C Chueh
Minority carrier diffusion length (LD) is a crucial property that determines the performance of light absorbers in photoelectrochemical (PEC) cells. Many transition-metal oxides are stable photoanodes for solar water splitting but exhibit a small to moderate LD, ranging from a few nanometers (such as α-Fe2O3 and TiO2) to a few tens of nanometers (such as BiVO4). Under operating conditions, temperature of PEC cells can deviate substantially from ambient, yet the temperature-dependence of LD has not been quantified...
August 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28817750/the-surgeon-on-service-model-for-timely-economically-viable-inpatient-care-of-tracheostomy-patients-in-academic-pediatric-otolaryngology
#4
Jennifer M Lavin, James W Schroeder, Dana M Thompson
Importance: The traditional practice model for pediatric otolaryngologists at high-volume academic centers is to simultaneously balance outpatient care responsibilities with those of the inpatient service, emergency department, and ambulatory care clinics. This model leads to challenges with care coordination, timeliness of nonemergency operative care, and consistent participation in care and consultation at the attending surgeon level. The "surgeon on service" (SOS) model-where faculty members rotate to manage the inpatient service in lieu of outpatient responsibilities-has been described as one method to address this conundrum...
August 17, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28817733/changing-patterns-of-cataract-services-in-north-west-nigeria-2005-2016
#5
Nasiru Muhammad, Mohammed Dantani Adamu, Mpyet Caleb, Nuhu Mohammed Maishanu, Aliyu Mohammed Jabo, Muhammad Mansur Rabiu, Covadonga Bascaran, Sunday Isiyaku, Allen Foster
PURPOSE: This study was conducted to assess the impact of the eye care programme on cataract blindness and cataract surgical services in Sokoto, Nigeria over a 12 year period 2005-2016. METHODS: Data from the 2005 population based cross-sectional study of blindness in Sokoto state was re-analysed to obtain baseline estimates of the prevalence of cataract blindness and cataract surgical coverage for persons 50 years and over in Wurno health zone. A population based survey of a representative sample of persons 50 years and over in Wurno health zone was conducted in July 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28817711/on-chip-detection-of-gel-transition-temperature-using-a-novel-micro-thermomechanical-method
#6
Tsenguun Byambadorj, Erfan Dashtimoghadam, Mohamadali Malakoutian, Benyamin Davaji, Lobat Tayebi, James E Richie, Chung Hoon Lee
We present a new thermomechanical method and a platform to measure the phase transition temperature at microscale. A thin film metal sensor on a membrane simultaneously measures both temperature and mechanical strain of the sample during heating and cooling cycles. This thermomechanical principle of operation is described in detail. Physical hydrogel samples are prepared as a disc-shaped gels (200 μm thick and 1 mm diameter) and placed between an on-chip heater and sensor devices. The sol-gel transition temperature of gelatin solution at various concentrations, used as a model physical hydrogel, shows less than 3% deviation from in-depth rheological results...
2017: PloS One
https://www.readbyqxmd.com/read/28817703/quality-of-life-of-inguinal-hernia-patients-in-taiwan-the-application-of-the-hernia-specific-quality-of-life-assessment-instrument
#7
Chi-Cheng Huang, Feng-Chuan Tai, Tzung-Hsin Chou, Heng-Hui Lien, Jaan-Yeh Jeng, Thien-Fiew Ho, Ching-Shui Huang
BACKGROUND: With the development of prosthetic mesh and tension free techniques, the recurrence rate following inguinal hernia repair has been reduced, and hernia outcomes research should focus on post-operative quality of life and potential complications. STUDY DESIGN: A novel hernia quality of life assessment instrument, HERQL, was developed. The HERQL questionnaire comprises a 4-item summative pain score measuring pain and discomfort resulting from various strenuous activities...
2017: PloS One
https://www.readbyqxmd.com/read/28817702/global-gene-expression-analysis-of-the-response-of-physic-nut-jatropha-curcas-l-to-medium-and-long-term-nitrogen-deficiency
#8
Qi Kuang, Sheng Zhang, Pingzhi Wu, Yaping Chen, Meiru Li, Huawu Jiang, Guojiang Wu
Jatropha curcas L. is an important biofuel plant with excellent tolerance of barren environments. However, studies on the regulatory mechanisms that operate in this plant in response to nitrogen (N) shortage are scarce. In this study, genome-wide transcriptional profiles of the roots and leaves of 8-week old physic nut seedlings were analyzed after 2 and 16 days of N starvation. Enrichment results showed that genes associated with N metabolism, processing and regulation of RNA, and transport predominated among those showing alterations in expression...
2017: PloS One
https://www.readbyqxmd.com/read/28817643/peripheral-clinic-versus-centralized-laboratory-based-xpert-mtb-rif-performance-experience-gained-from-a-pragmatic-stepped-wedge-trial-in-botswana
#9
Tefera Agizew, Rosanna Boyd, Ndwapi Ndwapi, Andrew Auld, Joyce Basotli, Sambayawo Nyirenda, Zegabriel Tedla, Anikie Mathoma, Unami Mathebula, Chawangwa Lesedi, Sherri Pals, Anand Date, Heather Alexander, Thomas Kuebrich, Alyssa Finlay
BACKGROUND: In 2011, the Botswana National Tuberculosis Program adopted World Health Organization guidelines and introduced Xpert MTB/RIF (Xpert) assay to support intensified case finding among people living with HIV enrolling in care. An evaluation was designed to assess performance under operational conditions to inform the national Xpert scale-up. METHODS: Xpert was implemented from August 2012 through November 2014 with 13 GeneXpert instruments (GeneXpert) deployed in a phased approach over nine months: nine centralized laboratory and four point-of-care (POC) peripheral clinics...
2017: PloS One
https://www.readbyqxmd.com/read/28817641/honey-bee-apis-mellifera-colony-health-and-pathogen-composition-in-migratory-beekeeping-operations-involved-in-california-almond-pollination
#10
William Glenny, Ian Cavigli, Katie F Daughenbaugh, Rosemarie Radford, Susan E Kegley, Michelle L Flenniken
Honey bees are important pollinators of agricultural crops. Pathogens and other factors have been implicated in high annual losses of honey bee colonies in North America and some European countries. To further investigate the relationship between multiple factors, including pathogen prevalence and abundance and colony health, we monitored commercially managed migratory honey bee colonies involved in California almond pollination in 2014. At each sampling event, honey bee colony health was assessed, using colony population size as a proxy for health, and the prevalence and abundance of seven honey bee pathogens was evaluated using PCR and quantitative PCR, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28817618/national-scale-cropland-mapping-based-on-spectral-temporal-features-and-outdated-land-cover-information
#11
François Waldner, Matthew C Hansen, Peter V Potapov, Fabian Löw, Terence Newby, Stefanus Ferreira, Pierre Defourny
The lack of sufficient ground truth data has always constrained supervised learning, thereby hindering the generation of up-to-date satellite-derived thematic maps. This is all the more true for those applications requiring frequent updates over large areas such as cropland mapping. Therefore, we present a method enabling the automated production of spatially consistent cropland maps at the national scale, based on spectral-temporal features and outdated land cover information. Following an unsupervised approach, this method extracts reliable calibration pixels based on their labels in the outdated map and their spectral signatures...
2017: PloS One
https://www.readbyqxmd.com/read/28817617/comparison-of-lingual-mucosa-and-buccal-mucosa-grafts-used-in-inlay-urethroplasty-in-failed-hypospadias-of-pre-pubertal-boys-in-a-chinese-group
#12
Jin Hongyong, Chen Shuzhu, Wu Min, Ye Weijing, Liu Yidong
OBJECTIVE: The purpose of this study was to compare the outcomes of the buccal mucosa and lingual mucosa used in children who received multiple failed hypospadias surgeries. METHOD: We conducted a retrospective study of 62 children who received buccal or lingual mucosa graft urethroplasty in our hospital between 2012 and 2015. The ages ranged from 3.5-11 y. All cases included multiple failed hypospadias procedures, and the subjects received previous operations 2-3 times...
2017: PloS One
https://www.readbyqxmd.com/read/28817607/computer-aided-position-planning-of-miniplates-to-treat-facial-bone-defects
#13
Jan Egger, Jürgen Wallner, Markus Gall, Xiaojun Chen, Katja Schwenzer-Zimmerer, Knut Reinbacher, Dieter Schmalstieg
In this contribution, a software system for computer-aided position planning of miniplates to treat facial bone defects is proposed. The intra-operatively used bone plates have to be passively adapted on the underlying bone contours for adequate bone fragment stabilization. However, this procedure can lead to frequent intra-operatively performed material readjustments especially in complex surgical cases. Our approach is able to fit a selection of common implant models on the surgeon's desired position in a 3D computer model...
2017: PloS One
https://www.readbyqxmd.com/read/28817580/criticality-predicts-maximum-irregularity-in-recurrent-networks-of-excitatory-nodes
#14
Yahya Karimipanah, Zhengyu Ma, Ralf Wessel
A rigorous understanding of brain dynamics and function requires a conceptual bridge between multiple levels of organization, including neural spiking and network-level population activity. Mounting evidence suggests that neural networks of cerebral cortex operate at a critical regime, which is defined as a transition point between two phases of short lasting and chaotic activity. However, despite the fact that criticality brings about certain functional advantages for information processing, its supporting evidence is still far from conclusive, as it has been mostly based on power law scaling of size and durations of cascades of activity...
2017: PloS One
https://www.readbyqxmd.com/read/28817574/diffusion-tensor-imaging-profiles-reveal-specific-neural-tract-distortion-in-normal-pressure-hydrocephalus
#15
Nicole C Keong, Alonso Pena, Stephen J Price, Marek Czosnyka, Zofia Czosnyka, Elise E DeVito, Charlotte R Housden, Barbara J Sahakian, John D Pickard
BACKGROUND: The pathogenesis of normal pressure hydrocephalus (NPH) remains unclear which limits both early diagnosis and prognostication. The responsiveness to intervention of differing, complex and concurrent injury patterns on imaging have not been well-characterized. We used diffusion tensor imaging (DTI) to explore the topography and reversibility of white matter injury in NPH pre- and early after shunting. METHODS: Twenty-five participants (sixteen NPH patients and nine healthy controls) underwent DTI, pre-operatively and at two weeks post-intervention in patients...
2017: PloS One
https://www.readbyqxmd.com/read/28817568/an-optimal-strategy-for-epilepsy-surgery-disruption-of-the-rich-club
#16
Marinho A Lopes, Mark P Richardson, Eugenio Abela, Christian Rummel, Kaspar Schindler, Marc Goodfellow, John R Terry
Surgery is a therapeutic option for people with epilepsy whose seizures are not controlled by anti-epilepsy drugs. In pre-surgical planning, an array of data modalities, often including intra-cranial EEG, is used in an attempt to map regions of the brain thought to be crucial for the generation of seizures. These regions are then resected with the hope that the individual is rendered seizure free as a consequence. However, post-operative seizure freedom is currently sub-optimal, suggesting that the pre-surgical assessment may be improved by taking advantage of a mechanistic understanding of seizure generation in large brain networks...
August 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28817483/time-course-study-on-left-ventricular-function-in-a-rabbit-model-of-ischemia-reperfusion-injury-with-morphine-preconditioning
#17
Baihua Zhao, Chengxiao Liu, Darong Pu, Shi Zeng, Xi Dai, Minghui Liu
AIMS: The study aimed to analyze the left ventricular longitudinal function in a rabbit model of myocardial ischemia-reperfusion with morphine preconditioning through strain rate imaging and evaluate the effect of morphine preconditioning. METHODS: A myocardial ischemia-reperfusion model was induced by occlusion and recanalization of the coronary artery in forty male New Zealand white rabbits, which were divided into a sham group, morphine group, and vehicle control group...
August 15, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28817462/fecal-calprotectin-more-accurately-predicts-endoscopic-remission-of-crohn-s-disease-than-serological-biomarkers-evaluated-using-balloon-assisted-enteroscopy
#18
Kousaku Kawashima, Shunji Ishihara, Takafumi Yuki, Nobuhiko Fukuba, Hiroki Sonoyama, Hideaki Kazumori, Noritsugu Yamashita, Yasumasa Tada, Ryusaku Kusunoki, Akihiko Oka, Naoki Oshima, Yoshiyuki Mishima, Ichiro Moriyama, Yoshikazu Kinoshita
BACKGROUND: Fecal calprotectin (FC) has emerged as a reliable surrogate marker of endoscopic remission in Crohn's disease (CD), which has been mainly evaluated using ileocolonoscopy. We conducted this study to clarify the predictability of FC level for predicting endoscopic remission using balloon-assisted enteroscopy (BAE) findings in patients with CD and compare with that of conventional serological biomarkers. METHODS: Patients with CD scheduled to undergo BAE were prospectively enrolled, and fecal and blood samples collected before the procedures...
August 16, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28817456/role-of-various-semiquantitative-parameters-of-18f-fdg-pet-ct-studies-for-interim-treatment-response-evaluation-in-non-small-cell-lung-cancer
#19
Akshima Sharma, Anant Mohan, Ashu Seith Bhalla, Sreenivas Vishnubhatla, Anil Kumar Pandey, Chandra Sekhar Bal, Rakesh Kumar
PURPOSE: The aim of this study was to prospectively evaluate the role of various semiquantitative parameters obtained from fluorine-18 fluorodeoxyglucose (F-FDG) PET/CT in interim treatment response assessment in biopsy-proven non-small-cell lung cancer (NSCLC) and to find the best parameter, if any. MATERIALS AND METHODS: Totally, 32 patients (male/female: 25/7) with biopsy proven NSCLC and a mean age of 54.71±12.65 years were enrolled in the study. Each patient underwent whole-body F-FDG PET/CT scan after injecting 5...
August 16, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28817439/faculty-development-for-the-operating-room-an-examination-of-the-effectiveness-of-an-intraoperative-teaching-course-for-surgeons
#20
Aimee K Gardner, Matthew D Timberlake, Brian J Dunkin
OBJECTIVE: We describe a half-day faculty development course designed to equip surgical educators with evidence-based teaching frameworks shown to promote learning in the operating room (OR). We hypothesize that participating faculty will deliver improved instruction as perceived by residents. METHODS: Residents anonymously rated faculty teaching behaviors among whom they had recently worked in the OR (minimum 3 cases in preceding 6 months) using the Briefing - Intraoperative teaching - Debriefing Assessment Tool (BIDAT; 1 = never, 5 = always)...
August 16, 2017: Annals of Surgery
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