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https://www.readbyqxmd.com/read/28551927/-percutaneous-correction-of-forefoot-deformities-in-diabetic-patients-in-order-to-prevent-pressure-sores-technique-and-results-in-20-consecutive-patients
#1
Mustafa Yassin, Avraham Garti, Eyal Heller, Moshe Weissbrot, Dror Robinson
INTRODUCTION: Diabetes mellitus is a 21st century pandemic. Due to life-span prolongation combined with the increased rate of diabetes, a growing population of patients is afflicted with neuropathic foot deformities. Traditional operative repair of these deformities is associated with a high complication rate and relatively common infection incidence. In recent years, in order to prevent these complications, percutaneous deformity correction methods were developed. OBJECTIVES: Description of experience accumulated in treating 20 consecutive patients with diabetic neuropathic foot deformities treated in a percutaneous fashion...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551895/-sentinel-lymph-nodes-dissection-in-gynecological-malignancies
#2
REVIEW
Yael Naaman, Limor Goldenhersh, Alon Ben-Arie
During the last decade sentinel lymph nodes biopsy has become an essential part of primary surgical treatment in a number of malignancies including breast cancer, melanoma and head-and-neck malignancies. Dye or radioactive substances are injected at the primary tumor site, followed by pre-operative and intra-operative mapping. During surgery only positive lymph nodes are being dissected instead of a complete dissection of the lymphatic basin. The advantages of sentinel lymph nodes dissection are reducing the side effects of extensive lymph nodes dissection, while maintaining high detection rates and sensitivity in identifying cases with lymphatic tumor spread...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551894/-advanced-abdominal-pregnancy
#3
REVIEW
David Rabinerson, Alexandra Berezowsky, Rinnat Gabbay-Benziv
Abdominal pregnancy is a very rare obstetric complication which is seriously hazardous to the mother as well as the fetus. It poses a diagnostic challenge to this day. Both maternal and fetal mortality rates in such cases are high, as well as the malformation rate among the affected fetus. The best diagnostic tools are ultrasound and MRI. The availability of these instruments, and especially the latter, is scarce in developing countries, hence the higher rate of this type of pregnancy in these regions. The higher incidence of abdominal pregnancy in developing countries is also associated with the greater prevalence of low socioeconomic status, pelvic infections and infertility - all are more prevalent in these countries...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551856/model-based-intensification-of-a-fed-batch-microbial-process-for-the-maximization-of-polyhydroxybutyrate-phb-production-rate
#4
Giannis Penloglou, Athina Vasileiadou, Christos Chatzidoukas, Costas Kiparissides
An integrated metabolic-polymerization-macroscopic model, describing the microbial production of polyhydroxybutyrate (PHB) in Azohydromonas lata bacteria, was developed and validated using a comprehensive series of experimental measurements. The model accounted for biomass growth, biopolymer accumulation, carbon and nitrogen sources utilization, oxygen mass transfer and uptake rates and average molecular weights of the accumulated PHB, produced under batch and fed-batch cultivation conditions. Model predictions were in excellent agreement with experimental measurements...
May 27, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28551848/mri-features-of-pediatric-intracranial-germ-cell-tumor-subtypes
#5
Chih-Chun Wu, Wan-Yuo Guo, Feng-Chi Chang, Chao-Bao Luo, Han-Jui Lee, Yi-Wei Chen, Yi-Yen Lee, Tai-Tong Wong
Intracranial germ cell tumors differ in histology and location, and require different clinical management strategies. We characterized the imaging features that may aid pre-operative differentiation of intracranial germinomas and non-germinomatous germ cell tumors (NGGCTs). This retrospective study analyzed 85 patients with intracranial germ cell tumors and adequate preoperative or pretreatment MRIs between 2000 and 2013 at our institution. Pretreatment MRI characteristics, apparent diffusion coefficient (ADC) values, tumor histopathology, and patient outcomes were compared...
May 27, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28551834/increased-bone-tracer-uptake-in-symptomatic-patients-with-acl-graft-insufficiency-a-correlation-of-mri-and-spect-ct-findings
#6
Dominic T Mathis, Anna Hirschmann, Anna L Falkowski, Tommi Kiekara, Felix Amsler, Helmut Rasch, Michael T Hirschmann
PURPOSE: Magnetic resonance imaging (MRI) and single-photon emission computerised tomography/computerised tomography (SPECT/CT) are used as diagnostic tools in symptomatic patients after reconstruction of the anterior cruciate ligament (ACL). The benefit of SPECT/CT in comparison with MRI is under debate. The purpose of this study was to investigate whether and how bone tracer uptake (BTU) intensity and distribution in SPECT/CT correlate with MRI findings in symptomatic patients after ACL reconstruction...
May 27, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28551828/rate-and-mode-of-screw-misplacements-after-3d-fluoroscopy-navigation-assisted-insertion-and-3d-imaging-control-of-1547-pedicle-screws-in-spinal-levels-t10-s1-related-to-vertebrae-and-spinal-sections
#7
Horst Balling, Thomas R Blattert
PURPOSE: In the field of spinal surgery, 3D-fluoroscopy navigation-assisted pedicle screw (PS) insertion with intra-operative 3D-image control represents a modern application of contemporary navigation technology. In literature, sectional or vertebral accuracy limitations of this image-guidance approach are not profoundly specified. This observational study explicitly differentiates accuracy rates and misplacement mode between spinal sections and single vertebrae from T10 to S1 using a navigation-assisted approach...
May 27, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28551825/necroptosis-and-ferroptosis-are-alternative-cell-death-pathways-that-operate-in-acute-kidney-failure
#8
Tammo Müller, Christin Dewitz, Jessica Schmitz, Anna Sophia Schröder, Jan Hinrich Bräsen, Brent R Stockwell, James M Murphy, Ulrich Kunzendorf, Stefan Krautwald
Ferroptosis is a recently recognized caspase-independent form of regulated cell death that is characterized by the accumulation of lethal lipid ROS produced through iron-dependent lipid peroxidation. Considering that regulation of fatty acid metabolism is responsible for the membrane-resident pool of oxidizable fatty acids that undergo lipid peroxidation in ferroptotic processes, we examined the contribution of the key fatty acid metabolism enzyme, acyl-CoA synthetase long-chain family member 4 (ACSL4), in regulating ferroptosis...
May 27, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28551770/quality-of-life-following-prophylactic-gynecological-surgery-experiences-of-female-lynch-mutation-carriers
#9
Holly Etchegary, Elizabeth Dicks, Laura Tamutis, Lesa Dawson
Lynch syndrome (LS) is a genetic condition conferring an elevated risk of gastrointestinal, gynecologic and other malignancies, often before the age of 50. Current guidelines recommend prophylactic gynecologic surgery to manage inherited cancers for female mutation carriers. Data is lacking on women's quality of life following surgery. In this pilot study, we explored how women described their quality of life post-prophylactic gynecologic surgery and the factors that affected post-surgery experiences. A qualitative interview study was the chosen design...
May 27, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28551764/autofluorescence-spectroscopy-for-nerve-sparing-laser-surgery-of-the-head-and-neck-the-influence-of-laser-tissue-interaction
#10
Florian Stelzle, Maximilian Rohde, Max Riemann, Nicolai Oetter, Werner Adler, Katja Tangermann-Gerk, Michael Schmidt, Christian Knipfer
The use of remote optical feedback systems represents a promising approach for minimally invasive, nerve-sparing laser surgery. Autofluorescence properties can be exploited for a fast, robust identification of nervous tissue. With regard to the crucial step towards clinical application, the impact of laser ablation on optical properties in the vicinity of structures of the head and neck has not been investigated up to now. We acquired 24,298 autofluorescence spectra from 135 tissue samples (nine ex vivo tissue types from 15 bisected pig heads) both before and after ER:YAG laser ablation...
May 27, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28551763/mesenchymal-stromal-cell-and-osteoblast-responses-to-oxidized-titanium-surfaces-pre-treated-with-%C3%AE-%C3%A2-%C3%A2-808%C3%A2-nm-gaalas-diode-laser-or-chlorhexidine-in-vitro-study
#11
Flaminia Chellini, Marco Giannelli, Alessia Tani, Lara Ballerini, Larissa Vallone, Daniele Nosi, Sandra Zecchi-Orlandini, Chiara Sassoli
Preservation of implant biocompatibility following peri-implantitis treatments is a crucial issue in odontostomatological practice, being closely linked to implant re-osseointegration. Our aim was to assess the responses of osteoblast-like Saos2 cells and adult human bone marrow-mesenchymal stromal cells (MSCs) to oxidized titanium surfaces (TiUnite(®), TiU) pre-treated with a 808 ± 10 nm GaAlAs diode laser operating in non-contact mode, in continuous (2 W, 400 J/cm(2); CW) or pulsed (20 kHz, 7 μs, 0...
May 27, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28551718/pelvic-artery-aneurysm-screening-provides-value-in-patients-with-thoracic-aortic-aneurysms
#12
Matthew Chapman, Leslie E Quint, Kuanwong Watcharotone, Bin Nan, Michael J Ranella, Mariana R DeFreitas, Joanna R Hider, Jonathan L Eliason, Himanshu J Patel
Approximately ¼ of patients with thoracic aortic aneurysms (TAAs) have concomitant abdominal aortic aneurysms (AAAs), thereby justifying the addition of an abdominal CT scan to a chest CT scan in patients with a newly diagnosed or suspected TAA. However, the prevalence of pelvic artery aneurysms (PAAs) in these patients is unknown. The purpose of this study was to determine the prevalence of PAAs in patients with TAAs and to assess what patient specific factors were associated with PAAs, thereby providing insight into the usefulness of pelvic imaging in TAA patients...
May 27, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28551711/why-are-most-phospholipidosis-inducers-also-herg-blockers
#13
Svetoslav Slavov, Iva Stoyanova-Slavova, Shuaizhang Li, Jinghua Zhao, Ruili Huang, Menghang Xia, Richard Beger
Recent reports have noted that a number of compounds that block the human Ether-à-go-go related gene (hERG) ion channel also induce phospholipidosis (PLD). To explore a hypothesis explaining why most PLD inducers are also hERG inhibitors, a modeling approach was undertaken with data sets comprised of 4096 compounds assayed for hERG inhibition and 5490 compounds assayed for PLD induction. To eliminate the chemical domain effect, a filtered data set of 567 compounds tested in quantitative high-throughput screening (qHTS) format for both hERG inhibition and PLD induction was constructed...
May 27, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28551702/alpha-7-nicotinic-receptor-signaling-pathway-participates-in-the-neurogenesis-induced-by-chat-positive-neurons-in-the-subventricular-zone
#14
Jianping Wang, Zhengfang Lu, Xiaojie Fu, Di Zhang, Lie Yu, Nan Li, Yufeng Gao, Xianliang Liu, Chunmao Yin, Junji Ke, Liyuan Li, Mengmeng Zhai, Shiwen Wu, Jiahong Fan, Liang Lv, Junchao Liu, Xuemei Chen, Qingwu Yang, Jian Wang
Choline acetyltransferase-positive (ChAT(+)) neurons within the subventricular zone (SVZ) have been shown to promote neurogenesis after stroke in mice by secreting acetylcholine (ACh); however, the mechanisms remain unclear. Receptors known to bind ACh include the nicotinic ACh receptors (nAChRs), which are present in the SVZ and have been shown to be important for cell proliferation, differentiation, and survival. In this study, we investigated the neurogenic role of the alpha-7 nAChR (α7 nAChR) in a mouse model of middle cerebral artery occlusion (MCAO) by using α7 nAChR inhibitor methyllycaconitine...
May 27, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28551684/exhaled-breath-condensate-acidification-occurs-during-surgery-for-abdominal-cancer
#15
Archontia Mahairidou, Sophia Rodopoulou, Ioannis Tomos, Eirini Maratou, Effrosyni Manali, Thomas Raptakis, Spyros A Papiris, Anna Karakatsani
BACKGROUND/AIM: Acidification of exhaled breath condensate (EBC), reflecting airway inflammation and oxidative stress, has been reported in lung cancer patients undergoing lobectomy. We undertook this study to examine EBC pH changes during surgery for abdominal cancer. PATIENTS AND METHODS: EBC pH was measured from 20 patients undergoing abdominal cancer resection before and during surgery. Repeated-measures of ANOVA and random-effects linear models were applied to compare mean EBC pH values in samples collected at different times...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551656/assessments-of-neoadjuvant-hormone-therapy-followed-by-robotic-assisted-radical-prostatectomy-for-intermediate-and-high-risk-prostate-cancer
#16
Ju-Chuan Hu, Sheng-Chun Hung, Yen-Chuan Ou
BACKGROUND/AIM: It is still unclear whether neoadjuvant hormone therapy (NHT) followed by radical prostatectomy is the best treatment option for advanced prostate cancer. This study aimed to evaluate the benefits of NHT followed by robotic-assisted laparoscopic radical prostatectomy (RaLP) in locally advanced prostate cancer. PATIENTS AND METHODS: This study included 48 patients that had received NHT prior to RaLP by a single surgeon. The control group was selected using computerized 1:1 ratio matching...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551580/cu-and-cd-affect-distinctly-the-physiology-of-a-cosmopolitan-tropical-freshwater-phytoplankton
#17
Pedro Echeveste, Jaqueline C Silva, Ana T Lombardi
Copper and Cd are natural constituents of freshwater ecosystems, both cycling influenced by microbial communities. The present research examined the impacts of environmentally relevant concentrations of Cu and Cd on the growth, viability, cell size, chlorophyll a (Chl a) content and photochemical efficiency of the tropical freshwater phytoplankton Chlorolobion braunii. Cell growth was significantly impaired by Cu and Cd, with EC50 occurring at 33.6 and 1.6µM, respectively. At sublethal levels (< EC50), cell death was already induced at 5µM Cu and 1µMCd...
May 25, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28551563/microwave-pyrolysis-of-textile-dyeing-sludge-in-a-continuously-operated-auger-reactor-condensates-and-non-condensable-gases
#18
Zuopeng Gao, Hedong Zhang, Wenya Ao, Jing Li, Guangqing Liu, Xiaochun Chen, Jie Fu, Chunmei Ran, Yang Liu, Qinhao Kang, Xiao Mao, Jianjun Dai
This paper investigated an auger pyrolyser under microwave irradiation using textile dyeing sludge (DS) as the feedstock. Microwave power, temperature, auger speed, gas velocity and addition of catalysts were studied. In terms of ICP-MS, Cu and As concentrations in condensates, depending on pyrolysis temperatures, exceeded the wastewater discharge standard in China. The condensate and oil yields reached maximum (i.e. 12.86 wt% and 0.84 wt%, respectively) at 650 °C. The content of aromatic compounds in the oil increased as temperature increased, up to 88...
May 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28551536/decision-making-in-irrigation-networks-selecting-appropriate-canal-structures-using-multi-attribute-decision-analysis
#19
Zeinab Hosseinzade, Sheree A Pagsuyoin, Kumaraswamy Ponnambalam, Mohammad J Monem
The stiff competition for water between agriculture and non-agricultural production sectors makes it necessary to have effective management of irrigation networks in farms. However, the process of selecting flow control structures in irrigation networks is highly complex and involves different levels of decision makers. In this paper, we apply multi-attribute decision making (MADM) methodology to develop a decision analysis (DA) framework for evaluating, ranking and selecting check and intake structures for irrigation canals...
May 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28551535/microbial-community-shifts-in-a-farm-scale-anaerobic-digester-treating-swine-waste-correlations-between-bacteria-communities-associated-with-hydrogenotrophic-methanogens-and-environmental-conditions
#20
Kyungjin Cho, Seung Gu Shin, Woong Kim, Joonyeob Lee, Changsoo Lee, Seokhwan Hwang
Microbial community structure in a farm-scale anaerobic digester treating swine manure was investigated during three process events: 1) prolonged starvation, and changes of 2) operating temperature (between meso- and thermophilic) and 3) hydraulic retention time (HRT). Except during the initial period, the digester was dominated by hydrogenotrophic methanogens (HMs). The bacterial community structure significantly shifted with operating temperature and HRT but not with long-term starvation. Clostridiales (26...
May 25, 2017: Science of the Total Environment
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